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Renal Supportive care

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https://www.readbyqxmd.com/read/29451695/decreased-early-mortality-associated-with-the-treatment-of-acute-myeloid-leukemia-at-national-cancer-institute-designated-cancer-centers-in-california
#1
Gwendolyn Ho, Ted Wun, Lori Muffly, Qian Li, Ann Brunson, Aaron S Rosenberg, Brian A Jonas, Theresa H M Keegan
BACKGROUND: To the authors' knowledge, few population-based studies to date have evaluated the association between location of care, complications with induction therapy, and early mortality in patients with acute myeloid leukemia (AML). METHODS: Using linked data from the California Cancer Registry and Patient Discharge Dataset (1999-2014), the authors identified adult (aged ≥18 years) patients with AML who received inpatient treatment within 30 days of diagnosis...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29442057/inguinal-hernia-repair-in-day-surgery-the-role-of-mac-monitored-anesthesia-care-with-remifentanil
#2
P Palumbo, S Usai, C Amatucci, B Perotti, L Ruggeri, G Illuminati, G Tellan
BACKGROUND: The extension of indications for procedures in a Day Surgery (DS) setting has led to changes in the anesthetic and surgical treatment of Inguinal Hernias (IH). According to the recommendations of the European Hernia Society, the treatment of IH in DS units should be performed under Monitored Anesthesia Care (MAC). PATIENTS AND METHODS: 960 patients underwent IH repairs over a period of 24 months. The patients were randomly divided into two groups: R (remifentanil) and F (fentanyl); the group F was considered as a control group...
November 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29440481/prospective-evaluation-of-medication-related-clinical-decision-support-over-rides-in-the-intensive-care-unit
#3
Adrian Wong, Mary G Amato, Diane L Seger, Christine Rehr, Adam Wright, Sarah P Slight, Patrick E Beeler, E John Orav, David W Bates
BACKGROUND: Clinical decision support (CDS) displayed in electronic health records has been found to reduce the incidence of medication errors and adverse drug events (ADE). Recent data suggested that medication-related CDS alerts were frequently over-ridden, often inappropriately. Patients in the intensive care unit (ICU) are at an increased risk of ADEs; however, limited data exist on the benefits of CDS in the ICU. This study aims to evaluate potential harm associated with medication-related CDS over-rides in the ICU...
February 9, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29429201/-survey-on-the-prevalence-of-continuous-blood-purification-in-chinese-pediatric-critical-care
#4
X Yang, S Y Qian, Y M Zhu, X Xu, C F Liu, F Xu, X X Ren, Y Wang, Y C Zhang, G P Lu
Objective: To investigate the current application status of continuous blood purification (CBP) technology and equipment in pediatric intensive care unit (PICU) in China. Methods: A cross-sectional survey was conducted to understand the current popularization of CBP technology and equipment, the management of CBP equipment and consumables, and the application of CBP in different diseases. A questionnaire named Application Status of Continuous Blood Purification Technology was applied. Children's hospitals and polyclinic hospitals with the pediatric qualification (pediatric emergency or critical care unit members of Chinese Medical Association and Chinese Medical Doctor Association) were selected...
February 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29427478/from-ruling-out-to-ruling-in-putting-pocus-in-focus
#5
Arjun K Venkatesh, Charles D Scales, Marta E Heilbrun
Over the past twenty years, the Emergency Department (ED) has transformed from a location that managed patients with acute life-threatening illness or injury to an acute diagnostic center. The advent of rapid and accurate imaging, novel biomarkers, and other innovations concurrent with effects from financial and social forces has supported the development of an acute care system focused on "ruling out" low-frequency, high-mortality events such as acute myocardial infarction, stroke, pulmonary embolism, and aortic dissection...
February 10, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29424248/evaluation-of-changes-in-renal-function-in-paramount-a-phase-iii-study-of-maintenance-pemetrexed-plus-best-supportive-care-versus-placebo-plus-best-supportive-care-after-induction-treatment-with-pemetrexed-plus-cisplatin-for-advanced-nonsquamous-non-small-cell
#6
Gary Middleton, Cesare Gridelli, Filippo De Marinis, Jean-Louis Pujol, Martin Reck, Rodryg Ramlau, Barbara Parente, Thierry Pieters, Carla M Visseren-Grul, Bélen San Antonio, William J John, Annamaria Hayden Zimmermann, Nadia Chouaki, Luis Paz-Ares
OBJECTIVES: To assess the long-term pemetrexed maintenance therapy on patients' renal function. METHODS: In the PARAMOUNT Phase III trial (NCT 00789373), pemetrexed was compared with placebo as maintenance treatment in advanced nonsquamous non-small-cell lung cancer patients who completed 4 cycles of pemetrexed plus cisplatin induction therapy. To evaluate changes in renal function during pemetrexed continuation maintenance treatment, we retrospectively analyzed changes in serum creatinine (sCr), treatment-emergent adverse events, dose delays, and treatment discontinuations associated with impaired renal function...
February 9, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29423204/practical-approaches-to-the-management-of-autosomal-dominant-polycystic-kidney-disease-patients-in-the-era-of-tolvaptan
#7
Roman-Ulrich Müller, Christian S Haas, John A Sayer
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease worldwide. The renal phenotype is characterized by progressive cystic enlargement of the kidneys leading to a decline in renal function, hypertension and often end-stage renal disease (ESRD). Supportive care with blood pressure control and management of pain, urinary infections and renal stone disease has, until recently, been the mainstay of treatment. With the recent approval of tolvaptan for use in ADPKD, the disease progression may now be targeted specifically...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29422725/clinical-profile-intensive-care-unit-course-and-outcome-of-patients-admitted-in-intensive-care-unit-with-chikungunya
#8
Anish Gupta, Deven Juneja, Omender Singh, Suneel Kumar Garg, Varun Arora, Desh Deepak
Objective: Chikungunya is generally a mild disease, rarely requiring Intensive Care Unit (ICU) admission. However, certain populations may develop organ dysfunction necessitating ICU admission. The purpose of the study was to assess the clinical profile and course of chikungunya patients admitted to the ICU, and to ascertain factors linked with poor outcome. Methods: All patients with chikungunya admitted to ICU were included in the study. Admission Acute Physiology and Chronic Health Evaluation (APACHE) II score and sequential organ failure assessment (SOFA) score were calculated...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29422067/predictors-of-hospital-mortality-in-adult-trauma-patients-receiving-extracorporeal-membrane-oxygenation-for-advanced-life-support-a-retrospective-cohort-study
#9
Meng-Yu Wu, Pin-Li Chou, Tzu-I Wu, Pyng-Jing Lin
BACKGROUND: Using extracorporeal membrane oxygenation (ECMO) to provide advanced life support in adult trauma patients remains a controversial issue now. The study was aimed at identifying the independent predictors of hospital mortality in adult trauma patients receiving ECMO for advanced cardiopulmonary dysfunctions. METHODS: This retrospective study enrolled 36 adult trauma patients receiving ECMO due to advanced shock or respiratory failure in a level I trauma center between August 2006 and October 2014...
February 8, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29420771/genitourinary-injuries-among-female-u-s-service-members-during-operation-iraqi-freedom-and-operation-enduring-freedom-findings-from-the-trauma-outcomes-and-urogenital-health-tough-project
#10
Amy M Reed, Judson C Janak, Jean A Orman, Steven J Hudak
Introduction: Until recently, female U.S. service members (SMs) have not been permitted to serve in direct combat roles. However, during Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), a large number of female SMs have been wounded while serving in combat support roles. This included an unprecedented number of women with genitourinary (GU) injuries. No previous studies have reported either the incidence or clinical picture of these injuries. The objective of this study is to describe the epidemiology of GU injuries among female U...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29413210/escherichia-coli-complications-in-pediatric-critical-care
#11
REVIEW
Suzanne S Puentes, Michele Dunstan
Escherichia coli is a bacterium that is an important part of the intestinal tract; however, it has the potential to become pathogenic. Shiga toxin-producing E coli (STEC) is a leading cause of E coli infections and has led to outbreaks in North America. Transmission is through ingestion of contaminated food sources, and via infected humans and animals. Young children infected with STEC are at high risk for developing hemolytic uremic syndrome (HUS). HUS is a clinical syndrome characterized by macroangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure...
March 2018: Critical Care Nursing Clinics of North America
https://www.readbyqxmd.com/read/29401514/patient-and-provider-experiences-with-active-surveillance-a-scoping-review
#12
Claire Kim, Frances C Wright, Nicole J Look Hong, Gary Groot, Lucy Helyer, Pamela Meiers, May Lynn Quan, Robin Urquhart, Rebecca Warburton, Anna R Gagliardi
OBJECTIVE: Active surveillance (AS) represents a fundamental shift in managing select cancer patients that initiates treatment only upon disease progression to avoid overtreatment. Given uncertain outcomes, patient engagement could support decision-making about AS. Little is known about how to optimize patient engagement for AS decision-making. This scoping review aimed to characterize research on patient and provider communication about AS, and associated determinants and outcomes. METHODS: MEDLINE, EMBASE, CINAHL, and The Cochrane Library were searched from 2006 to October 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29396136/renal-replacement-therapy-in-the-neonatal-intensive-care-unit
#13
Tze Yee Diane Mok, Min-Hua Tseng, Ming-Chou Chiang, Ju-Li Lin, Shih Ming Chu, Jen-Fu Hsu, Reyin Lien
BACKGROUND: Renal replacement therapy (RRT) is becoming increasingly necessary for supporting critically ill neonates. Few studies have reported the use of RRT in the neonatal intensive care unit (NICU). Therefore, we performed a retrospective study to describe the use of RRT in our NICU and its associated efficacy, complications, and outcomes. METHODS: We identified patients requiring RRT between January 2009 and January 2017. Demographic data, mode of RRT, and associated factors were recorded...
December 21, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29393193/technology-in-medicine-moving-towards-precision-management-of-acute-kidney-injury
#14
Jorge Cerdá, Gianluca Villa, Mauro Neri, Claudio Ronco
The integration of modern information communication technology and technologically advanced equipment to routine clinical practice are important technological stepping stones in the management of patients with acute kidney injury (AKI). These tools improve practice and patient outcomes by supporting and individualizing all phases of AKI management. This narrative review describes the most recent bedside technological advances in AKI diagnosis, renal replacement therapy education, prescription, monitoring, delivery, and measurement of outcomes with an emphasis on providing highly personalized patient care...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29393024/axitinib-cabozantinib-everolimus-nivolumab-sunitinib-and-best-supportive-care-in-previously-treated-renal-cell-carcinoma-a-systematic-review-and-economic-evaluation
#15
Steve J Edwards, Victoria Wakefield, Peter Cain, Charlotta Karner, Kayleigh Kew, Mariana Bacelar, Natalie Masento, Fatima Salih
BACKGROUND: Several therapies have recently been approved for use in the NHS for pretreated advanced or metastatic renal cell carcinoma (amRCC), but there is a lack of comparative evidence to guide decisions between them. OBJECTIVE: To evaluate the clinical effectiveness and cost-effectiveness of axitinib (Inlyta®, Pfizer Inc., NY, USA), cabozantinib (Cabometyx®, Ipsen, Slough, UK), everolimus (Afinitor®, Novartis, Basel, Switzerland), nivolumab (Opdivo®, Bristol-Myers Squibb, NY, USA), sunitinib (Sutent®, Pfizer, Inc...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29370971/high-dose-catecholamine-donor-support-and-outcomes-after-heart-transplantation
#16
Philipp Angleitner, Alexandra Kaider, Johannes Gökler, Roxana Moayedifar, Emilio Osorio-Jaramillo, Andreas Zuckermann, Günther Laufer, Arezu Aliabadi-Zuckermann
BACKGROUND: Higher dose norepinephrine donor support is a frequent reason for donor heart decline, but its associations with outcomes after heart transplantation are unclear. METHODS: We retrospectively analyzed 965 patients transplanted between 1992 and 2015 in the Heart Transplant Program Vienna. Stratification was performed according to donor norepinephrine dose administered before organ procurement (Group 0: 0 µg/kg/min; Group 1: 0.01 to 0.1 µg/kg/min; Group 2: >0...
December 20, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29370430/social-relationships-and-their-impact-on-health-related-outcomes-in-peritoneal-versus-haemodialysis-patients-a-prospective-cohort-study
#17
Denise Neumann, Juliane Lamprecht, Maxi Robinski, Wilfried Mau, Matthias Girndt
Background: Social relationships are important determinants of health-related outcomes for patients with chronic conditions. However, the effects of social networks and social support on health outcomes of dialysis patients in different treatment modalities have been under studied. Methods: We surveyed peritoneal dialysis (PD) and haemodialysis (HD) patients in the Choice of Renal Replacement Therapy project about their social relationships and health-care outcomes at baseline and 1-year follow-up...
January 23, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29369774/ciclosporin-for-epidermal-necrolysis-absence-of-beneficial-effect-in-a-retrospective-cohort-of-174-patients-exposed-unexposed-and-propensity-score-matched-analyses
#18
F Poizeau, O Gaudin, L Le Cleach, T A Duong, C Hua, C Hotz, S Ingen-Housz-Oro, E Sbidian, O Zehou, A Colin, N de Prost, B Lebrun-Vignes, O Chosidow, P Wolkenstein, L Fardet
Ciclosporin has shown promising results for mortality in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). However, available studies included only a small number of patients and did not include a validated and homogenous control group. We present the results from a retrospective monocentric study including 174 patients with SJS/TEN during 2005-2016. Among them, 95 received ciclosporin (3 mg/kg/day) plus supportive care and 79 supportive care only. Both a traditional exposed/unexposed method and a propensity-score matching method were used to compare the progression of skin detachment between day 0 and day 5, the proportion of patients with cutaneous re-epithelialization starting on day 5 or mucosal re-epithelialization on day 10, the duration of progression, and the number of deaths between the two groups...
January 21, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29359888/management-of-paediatric-high-grade-blunt-renal-trauma-a-10-year-single-centre-uk-experience
#19
Kee Yong Wong, Ram Jeeneea, Andrew Healey, Laurence Abernethy, Harriet Corbett, Fiona McAndrew, Paul Losty
INTRODUCTION: To report the management and outcome of paediatric patients sustaining high grade blunt renal trauma. PATIENTS AND METHODS: Medical records were examined for all Grade III to Grade V blunt renal trauma cases admitted to a paediatric trauma centre during the era(s) 2005 to 2015. Data collected and analysed included - demographics, imaging modalities, management, length of hospital stay, complications and follow-up outcome(s). RESULTS: 18 children (12 males, 6 females) with mean age 11 years (4 - 15) were included...
January 23, 2018: BJU International
https://www.readbyqxmd.com/read/29357407/informal-caregivers-experiences-of-caring-for-people-receiving-dialysis-a-mixed-methods-systematic-review
#20
REVIEW
Van Lan Hoang, Theresa Green, Ann Bonner
BACKGROUND: Living with end stage kidney disease and having dialysis is burdensome, and there is a need for support from informal caregivers (i.e. family members and friends). Renal health professionals readily acknowledge and value the support provided by caregivers although the activities and experiences of caring for a loved-one who is receiving dialysis is less well understood. OBJECTIVES: To review studies about the perspectives and experiences of family members and friends who provide support for adults receiving either haemodialysis or peritoneal dialysis...
January 22, 2018: Journal of Renal Care
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