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https://www.readbyqxmd.com/read/28924682/rehabilitation-for-cancer-patients
#1
Joachim Weis, Jürgen M Giesler
Rehabilitation for cancer patients aims at reducing the impact of disabling and limiting conditions resulting from cancer and its treatment in order to enable patients to regain social integration and participation. Given current trends in cancer incidence and survival along with progress in medical treatment, cancer rehabilitation is becoming increasingly important in contemporary health care. Although not without limitations, the International Classification of Functioning, Disability and Health (ICF) provides a valuable perspective for cancer rehabilitation in understanding impairments in functioning and activity as the result of an interaction between a health condition and contextual factors...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28924678/gender-opportunities-in-psychosocial-oncology
#2
Matthew Loscalzo, Karen Clark
So much has happened since the original publication of this chapter. In some ways, the progress made in appreciating the full spectrum of sexual and gender expression has been uneven and in some nations, there has been serious regression and resulting repression. But overall, especially in the industrialized countries, there is much greater awareness of sex and gender and its importance in health and well being. In this updated chapter, we put sex and gender into a historical context that is relevant to psycho-oncology and that openly accepts that society overall, is highly conflicted when it comes to how women and men get the best out of each other, never mind how to best integrate lesbian, gay, bisexual, and transgender (LGBT) communities...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28921642/clinical-pharmacology-tools-and-evaluations-to-facilitate-comprehensive-dose-finding-in-oncology-a-continuous-risk-benefit-approach
#3
Julie M Bullock, Tiffany Lin, Sanela Bilic
Targeted therapies are now considered an integral component in the treatment armamentarium for many malignancies, and the approach to developing these drugs needs to be refined from the previous cytotoxic paradigm of toxicity-guided dose finding and identification of maximum tolerated dose to a paradigm driven by target activity. Moving away from the toxicity-driven dose finding and justification model requires an integrated approach in order to adequately characterize the risk-benefit of a drug. This approach starts with understanding the importance of collecting samples for pharmacokinetic and pharmacodynamic assessments in all phases of clinical development to fully characterize the pharmacokinetics and identify covariates and then correlating exposure to key markers of safety and efficacy in pharmacometric analyses to perform a robust risk-benefit assessment and establish the right dose...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28918552/long-term-quality-of-life-profile-in-oncology-a-comparison-between-cancer-survivors-and-the-general-population
#4
Maria Antonietta Annunziata, Barbara Muzzatti, Cristiana Flaiban, Katiuscia Gipponi, Carlo Carnaghi, Paolo Tralongo, Michele Caruso, Raffaele Cavina, Umberto Tirelli
PURPOSE: Understanding the quality of life (QoL) of cancer survivors is relevant to both clinical practice and health care policy. The current study compared the QoL profile in this specific population with that of a normative sample for the general population, as well as with those of both healthy and oncological patients normative sub-samples. In addition, associations between the obtained QoL profile and the main socio-demographic and clinical characteristics of the sample were examined...
September 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28917246/the-promise-of-stereotactic-body-radiotherapy-next-phase-of-integration-into-oncological-practice
#5
Kevin L M Chua, David B H Tan, Melvin L K Chua, Simon S Lo
No abstract text is available yet for this article.
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28916014/integrated-behavioral-health-care-in-pediatric-subspecialty-clinics
#6
REVIEW
Chase Samsel, Monique Ribeiro, Patricia Ibeziako, David R DeMaso
Comorbid behavioral and physical health conditions are accompanied by troubling symptom burden, functional impairment, and treatment complexity. Pediatric subspecialty care clinics offer an opportunity for the implementation of integrated behavioral health (BH) care models that promote resiliency. This article reviews integrated BH care in oncology, palliative care, pain, neuropsychiatry, cystic fibrosis, and transplantation. Examples include integrated care mandates, standards of care, research, and quality improvement by child and adolescent psychiatrists (CAPs) and allied BH clinicians...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28915810/does-one-workshop-on-respecting-cultural-differences-increase-health-professionals-confidence-to-improve-the-care-of-australian-aboriginal-patients-with-cancer-an-evaluation
#7
Angela Durey, Georgia Halkett, Melissa Berg, Leanne Lester, Marion Kickett
BACKGROUND: Aboriginal Australians have worse cancer survival rates than other Australians. Reasons include fear of a cancer diagnosis, reluctance to attend mainstream health services and discrimination from health professionals. Offering health professionals education in care focusing on Aboriginal patients' needs is important. The aim of this paper was to evaluate whether participating in a workshop improved the confidence of radiation oncology health professionals in their knowledge, communication and ability to offer culturally safe healthcare to Aboriginal Australians with cancer...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28915075/responding-to-patient-requests-for-hastened-death-physician-aid-in-dying-and-the-clinical-oncologist
#8
Rebecca A Spence, Charles D Blanke, Thomas J Keating, Lynne P Taylor
Physician aid in dying (PAD) or assisted suicide is becoming legal in more US jurisdictions. Meanwhile, the needs of terminally ill patients with cancer are receiving greater attention, including the integration of palliative care into oncology practice. This article highlights a case vignette of a patient with advanced cancer who requests PAD from her oncologist, as a backdrop to help the practicing oncologist examine his or her moral stance regarding participation in aid in dying. The article concludes by offering a framework within which the practicing oncologist can receive and process a patient's request for PAD...
September 15, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28911084/the-critical-mass-survey-of-palliative-care-programme-at-esmo-designated-centres-of-integrated-oncology-and-palliative-care
#9
D Hui, N Cherny, N Latino, F Strasser
Background: The ESMO Designated Centres (ESMO-DCs) of Integrated Oncology and Palliative Care (PC) Incentive Programme has grown steadily. We aimed to characterise the level of PC clinical services, education and research at ESMO-DCs. Methods: We sent all 184 ESMO-DCs an electronic survey consisting of 78 questions examining the DC characteristics, palliative care clinical programme (structure, processes, and outcomes), primary PC delivery by oncologists, education, research and attitudes and beliefs towards the ESMO-DC programme...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28895233/validation-of-the-opportunity-for-treatment-in-oncology-option-questionnaire-measuring-continuity-of-care
#10
Paola Rucci, Silvia Foglino, Francesca Bravi, Rossella D'Avenia, Mattia Altini, Tiziano Carradori, Angela Angelastro, Maria Pia Fantini
Increasing efforts are ongoing to deliver effective cancer care through integrated networks of services. Measuring patients' experience of care is essential to identify problematic areas that require organisational adjustments. The aim of the present study was to examine the validity of OPTION questionnaire, designed to measure patient's perceived continuity of care across different phases of their care pathway. The study was carried at the Institute for Cancer Treatment and Research, Meldola and the oncology departments of the Local Health Authority of Romagna, Italy...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28894396/a-validation-of-clinical-data-captured-from-a-novel-cancer-care-quality-program-directly-integrated-with-administrative-claims-data
#11
David M Kern, John J Barron, Bingcao Wu, Alex Ganetsky, Vincent J Willey, Ralph A Quimbo, Michael J Fisch, Joseph Singer, Ann Nguyen, Ronac Mamtani
BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28894017/effects-of-early-integrated-palliative-care-on-caregivers-of-patients-with-lung-and-gastrointestinal-cancer-a-randomized-clinical-trial
#12
Areej El-Jawahri, Joseph A Greer, William F Pirl, Elyse R Park, Vicki A Jackson, Anthony L Back, Mihir Kamdar, Juliet Jacobsen, Eva H Chittenden, Simone P Rinaldi, Emily R Gallagher, Justin R Eusebio, Sarah Fishman, Harry VanDusen, Zhigang Li, Alona Muzikansky, Jennifer S Temel
BACKGROUND: The family and friends (caregivers) of patients with advanced cancer often experience tremendous distress. Although early integrated palliative care (PC) has been shown to improve patient-reported quality of life (QOL) and mood, its effects on caregivers' outcomes is currently unknown. MATERIALS AND METHODS: We conducted a randomized trial of early PC integrated with oncology care versus oncology care alone for patients who were newly diagnosed with incurable lung and noncolorectal gastrointestinal cancers and their caregivers...
September 11, 2017: Oncologist
https://www.readbyqxmd.com/read/28893059/dosimetric-advantages-and-clinical-outcomes-of-simultaneous-integrated-boost-intensity-modulated-radiotherapy-for-anal-squamous-cell-carcinoma
#13
Katsuyuki Sakanaka, Satoshi Itasaka, Yuichi Ishida, Kota Fujii, Takahiro Horimatsu, Takashi Mizowaki, Yoshiharu Sakai, Masahiro Hiraoka
Purpose: The purpose of this study was to explore the dosimetric difference between simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) and three-dimensional conformal radiotherapy (3DCRT), and the clinical outcomes of anal squamous cell carcinoma (ASCC) chemoradiotherapy featuring SIB-IMRT. Materials and Methods: This study included ten patients with ASCC who underwent chemoradiotherapy using SIB-IMRT with 5-fluorouracil and mitomycin C. SIB-IMRT delivered 54 Gy to each primary tumor plus metastatic lymph nodes and 45 Gy to regional lymph nodes, in 30 fractions...
September 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28890087/-therapeutic-innovations-in-radiation-oncology-for-localized-prostate-cancer
#14
G Créhange, L Cormier
Intensity-modulated radiation therapy, image-guided radiation therapy with fiducial markers and prostate brachytherapy allow the delivery of dose escalation for localized prostate cancer with very low rates of long-term toxicity and sequelae. Nowadays, modern radiotherapy techniques make it possible to shorten treatment time with hypofractionation, to better protect surrounding healthy tissues and to escalate the dose even further. Advances in radiotherapy are closely linked to advances in magnetic resonance imaging (MRI) and/or PET imaging...
September 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28888499/the-efficacy-of-art-therapy-in-pediatric-oncology-patients-an-integrative-literature-review
#15
REVIEW
Bree A Aguilar
PROBLEM: Children undergoing cancer treatment experience detrimental adverse side effects that may be addressed with complementary and alternative medicine (CAM) such as art therapy. The purpose of this research was to examine the effects of art therapy in pediatric patients living with cancer. ELIGIBILITY CRITERIA: An integrative literature review was conducted using the CINAHL, OVID Medline, and PsycINFO databases. Studies were included if they were a primary source utilizing an art therapy intervention in children with cancer age birth to 18years old, was published between the year 2000 and 2016, and written in the English language...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28887051/precision-oncology-the-road-ahead
#16
REVIEW
Daniela Senft, Mark D M Leiserson, Eytan Ruppin, Ze'ev A Ronai
Current efforts in precision oncology largely focus on the benefit of genomics-guided therapy. Yet, advances in sequencing techniques provide an unprecedented view of the complex genetic and nongenetic heterogeneity within individual tumors. Herein, we outline the benefits of integrating genomic and transcriptomic analyses for advanced precision oncology. We summarize relevant computational approaches to detect novel drivers and genetic vulnerabilities, suitable for therapeutic exploration. Clinically relevant platforms to functionally test predicted drugs/drug combinations for individual patients are reviewed...
September 5, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28882049/the-carrot-or-stick-integrating-palliative-care-into-oncology-practice
#17
Torrie K Fields
No abstract text is available yet for this article.
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28881702/the-epigenetic-integrator-uhrf1-on-the-road-to-become-a-universal-biomarker-for-cancer
#18
REVIEW
Waseem Ashraf, Abdulkhaleg Ibrahim, Mahmoud Alhosin, Liliyana Zaayter, Khalid Ouararhni, Christophe Papin, Tanveer Ahmad, Ali Hamiche, Yves Mély, Christian Bronner, Marc Mousli
Cancer is one of the deadliest diseases in the world causing record number of mortalities in both developed and undeveloped countries. Despite a lot of advances and breakthroughs in the field of oncology still, it is very hard to diagnose and treat the cancers at early stages. Here in this review we analyze the potential of Ubiquitin-like containing PHD and Ring Finger domain 1 (UHRF1) as a universal biomarker for cancers. UHRF1 is an important epigenetic regulator maintaining DNA methylation and histone code in the cell...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28879459/hypofractionated-radiotherapy-with-simultaneous-integrated-boost-sib-plus-temozolomide-in-good-prognosis-patients-with-glioblastoma-a-multicenter-phase-ii-study-by-the-brain-study-group-of-the-italian-association-of-radiation-oncology-airo
#19
Silvia Scoccianti, Marco Krengli, Livia Marrazzo, Stefano Maria Magrini, Beatrice Detti, Vincenzo Fusco, Luigi Pirtoli, Daniela Doino, Alba Fiorentino, Laura Masini, Daniela Greto, Michela Buglione, Giovanni Rubino, Federico Lonardi, Fernanda Migliaccio, Salvino Marzano, Riccardo Santoni, Umberto Ricardi, Lorenzo Livi
INTRODUCTION: A multicenter phase II study for assessing the efficacy and the toxicity of hypofractionated radiotherapy with SIB plus temozolomide in patients with glioblastoma was carried out by the Brain Study Group of the Italian Association of Radiation Oncology. METHODS: Twenty-four patients with newly diagnosed glioblastoma belonging to Recursive Partitioning Analysis classes III and IV were enrolled. The prescribed dose was 52.5 Gy in 15 fractions of 3.5 Gy and 67...
September 6, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28875369/-personalized-oncology
#20
REVIEW
C Heining, P Horak, S Gröschel, H Glimm, S Fröhling
CLINICAL ISSUE: Innovative next generation sequencing (NGS) technologies and comprehensive sequencing investigations in large patient cohorts have paved the way for very promising personalized treatment strategies based on the molecular characteristics of individual tumors. STANDARD TREATMENT: Targeted therapies, such as tyrosine kinase inhibitors, antibodies and modern immunotherapeutic approaches are well established as monotherapy and combination therapy for many hematological and oncological malignancies...
September 5, 2017: Der Radiologe
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