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Surgical Pathway

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https://www.readbyqxmd.com/read/29688432/glucagonoma-with-necrolytic-migratory-erythema-metabolic-profile-and-detection-of-biallelic-inactivation-of-daxx-gene
#1
Ai Tamura, Tatsuki Ogasawara, Yoichi Fujii, Hiyori Kaneko, Akitoshi Nakayama, Seiichiro Higuchi, Naoko Hashimoto, Yui Miyabayashi, Masanori Fujimoto, Eri Komai, Takashi Kono, Ikki Sakuma, Hidekazu Nagano, Sawako Suzuki, Hisashi Koide, Koutaro Yokote, Kozue Iseki, Rena Oguma, Hiroyuki Matsue, Hiroyuki Nojima, Kensuke Sugiura, Hideyuki Yoshitomi, Masayuki Ohtsuka, Bahityar Rahmutulla, Atsushi Kaneda, Naoko Inoshita, Seishi Ogawa, Tomoaki Tanaka
Context: Necrolytic migratory erythema (NME) occurs in approximately 70% of patients with glucagonoma syndrome. Excessive stimulation of metabolic pathways by hyperglucagonemia, which leads to hypoaminoacidemia, contributes to NME pathogenesis. However, the molecular pathogenesis of glucagonoma and relationships between metabolic abnormalities and clinical symptoms remain unclear. Case description: A 53-year-old woman was referred to our hospital with a generalized rash and weight loss...
April 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29687451/pro-osteogenic-properties-of-hydrophilic-and-hydrophobic-titanium-surfaces-crosstalk-between-signalling-pathways-in-in-vivo-models
#2
E Calciolari, S Hamlet, S Ivanovski, N Donos
BACKGROUND: It is now generally accepted that the response to a particular signal, such as the surgical trauma following implant placement, is not the result of a single linear signalling pathway, but rather reflects pathway integration, which can occur at multiple levels. Although it is well documented that both SLA and SLActive surfaces are able to promote bone formation and osseointegration, it is still unclear which are the key signalling pathways involved and how surface hydrophilicity/hydrophobicity might affect pathway integration...
April 23, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29687304/improved-outcomes-following-implementation-of-a-multidisciplinary-care-pathway-for-elderly-hip-fractures
#3
Raina Wallace, L D George Angus, Swapna Munnangi, Sally Shukry, Jody C DiGiacomo, Charles Ruotolo
BACKGROUND: Hip fractures in patients 65 years and older are associated with significant morbidity and mortality. With the steady increase in the elderly population, we implemented an evidence-based clinical practice guideline for the management of hip fractures to optimize patient care and surgical outcomes. AIMS: To evaluate the effects of a multidisciplinary hip fracture care pathway on patient outcomes in the care of elderly patients. METHODS: A retrospective analysis of the differences in outcomes prior to (January-October 2014) and after (November 2014-April 2016) implementation of a hip fracture care pathway at a regional Level I trauma center was performed...
April 23, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29687077/efficacy-and-outcomes-of-intrathecal-analgesia-as-part-of-an-enhanced-recovery-pathway-in-colon-and-rectal-surgical-patients
#4
Amit Merchea, Jenna K Lovely, Adam K Jacob, Dorin T Colibaseanu, Scott R Kelley, Kellie L Mathis, Grant M Spears, Marianne Huebner, David W Larson
Purpose: Multimodal analgesia is an essential component of an enhanced recovery pathway (ERP). An ERP that includes the use of single-injection intrathecal analgesia (IA) has been shown to decrease morbidity and cost and shorten length of stay (LOS). Limited data exist on safety, feasibility, and the optimal IA regimen. Our objective was to characterize the efficacy, safety, and feasibility of IA within an ERP in a cohort of colorectal surgical patients. Methods: We performed a retrospective review of all consecutive patients aged ≥ 18 years who underwent open or minimally invasive colorectal surgery from October 2012 to December 2013...
2018: Surgery Research and Practice
https://www.readbyqxmd.com/read/29686989/enhanced-recovery-after-surgery-protocols-in-major-urologic-surgery
#5
REVIEW
Natalija Vukovic, Ljubomir Dinic
The purpose of the review: The analysis of the components of enhanced recovery after surgery (ERAS) protocols in urologic surgery. Recent findings: ERAS protocols has been studied for over 20 years in different surgical procedures, mostly in colorectal surgery. The concept of improving patient care and reducing postoperative complications was also applied to major urologic surgery and especially procedure of radical cystectomy. This procedure is technically challenging, due to a major surgical resection and high postoperative complication rate that may reach 65%...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29684925/minimally-invasive-resection-of-deep-seated-high-grade-gliomas-using-tubular-retractors-and-exoscopic-visualization
#6
Rajiv Iyer, Kaisorn L Chaichana
BACKGROUND AND STUDY AIMS/OBJECTIVE:  Deep-seated high-grade gliomas (HGGs) represent a unique surgical challenge because they reside deep to critical cortical and subcortical structures and infiltrate functional areas of the brain. Therefore, accessing and resecting these tumors can often be challenging and associated with significant morbidity. We describe the use of minimally invasive approaches to access deep-seated HGGs to achieve extensive resections while minimizing surgical morbidity...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29682561/anti-inflammatory-effect-of-geniposide-on-osteoarthritis-by-suppressing-the-activation-of-p38-mapk-signaling-pathway
#7
Yuan Chen, Kangquan Shou, Chunlong Gong, Huarui Yang, Yi Yang, Tongzhu Bao
It has been suggested that the activation of the p38 mitogen activated protein kinases (MAPKs) signaling pathway plays a significant role in the progression of OA by leading to the overexpression of proinflammatory cytokines, chemokines, and signaling enzymes in human osteoarthritis chondrocytes. However, most p38 MAPK inhibitors applied for OA have been thought to be limited due to their potential long-term toxicities. Geniposide (GE), an iridoid glycoside purified from the fruit of the herb, has been widely used in traditional medicine for the treatment of a variety of chronic inflammatory diseases...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#8
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29682064/awake-craniotomy-with-noninvasive-brain-mapping-by-3-tesla-functional-magnetic-resonance-imaging-for-excision-of-low-grade-glioma-a-case-of-a-young-patient-from-pakistan
#9
Atta Ul Aleem Bhatti, Nasir Khan Jakhrani, Maria Adnan Parekh
The past few years have seen increasing support for gross total resection in the management of low-grade gliomas (LGGs), with a greater extent of resection correlated with better overall survival, progression-free survival, and time to malignant transformation. There is consistent evidence in literature supporting extent of safe resection as a good prognostic indicator as well as positively affecting seizure control, symptomatic relief in pressure symptoms, and longer progression-free and total survival. The operative goal in most LGG cases is to maximize the extent of resection for these benefits while avoiding postoperative neurologic deficits...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29679262/serum-osteoprotegerin-levels-and-mammographic-density-among-high-risk-women
#10
Olivia Moran, Tasnim Zaman, Andrea Eisen, Rochelle Demsky, Kristina Blackmore, Julia A Knight, Christine Elser, Ophira Ginsburg, Kevin Zbuk, Martin Yaffe, Steven A Narod, Leonardo Salmena, Joanne Kotsopoulos
PURPOSE: Mammographic density is a risk factor for breast cancer but the mechanism behind this association is unclear. The receptor activator of nuclear factor κB (RANK)/RANK ligand (RANKL) pathway has been implicated in the development of breast cancer. Given the role of RANK signaling in mammary epithelial cell proliferation, we hypothesized this pathway may also be associated with mammographic density. Osteoprotegerin (OPG), a decoy receptor for RANKL, is known to inhibit RANK signaling...
April 20, 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29678281/an-orphan-g-protein-coupled-receptor-causes-human-gigantism-and-or-acromegaly-molecular-biology-and-clinical-correlations
#11
REVIEW
Giampaolo Trivellin, Laura C Hernández-Ramírez, Jeremy Swan, Constantine A Stratakis
X-linked acrogigantism (X-LAG) is a recently described form of familial or sporadic pituitary gigantism characterized by very early onset GH and IGF-1 excess, accelerated growth velocity, gigantism and/or acromegaloid features. Germline or somatic microduplications of the Xq26.3 chromosomal region, invariably involving the GPR101 gene, constitute the genetic defect leading to X-LAG. GPR101 encodes a class A G protein-coupled receptor that activates the 3',5'-cyclic adenosine monophosphate signaling pathway...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29676691/defining-the-lateral-limits-of-the-endoscopic-endonasal-transtuberculum-transplanum-approach-anatomical-study-with-pertinent-quantitative-analysis
#12
Alberto Di Somma, Jorge Torales, Luigi Maria Cavallo, Jose Pineda, Domenico Solari, Rosa Maria Gerardi, Federico Frio, Joaquim Enseñat, Alberto Prats-Galino, Paolo Cappabianca
OBJECTIVE The extended endoscopic endonasal transtuberculum transplanum approach is currently used for the surgical treatment of selected midline anterior skull base lesions. Nevertheless, the possibility of accessing the lateral aspects of the planum sphenoidale could represent a limitation for such an approach. To the authors' knowledge, a clear definition of the eventual anatomical boundaries has not been delineated. Hence, the present study aimed to detail and quantify the maximum amount of bone removal over the planum sphenoidale required via the endonasal pathway to achieve the most lateral extension of such a corridor and to evaluate the relative surgical freedom...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676354/diagnostic-and-prognostic-impact-of-mucin-1-6-expression-in-non-small-cell-lung-cancer
#13
William Sterlacci, Michael Fiegl, Lothar Veits, Alexandar Tzankov
Background: The prognostic significance and clinico-pathological characterization of mucin (MUC) expression in non-small cell lung cancer (NSCLC) is controversial and little studied. Aims: This study aims at elucidating this issue on the largest and most detailed cohort so far. Settings and Design: We examined the expression of MUC 1, 2, 4, 5AC and 6 on 371, well documented, surgically resected NSCLC cases. Materials and Methods: Immunohistochemical results were correlated with several of our previously studied, relevant parameters on this cohort including a follow-up period of up to 20 years...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#14
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29673951/revealing-the-cerebello-ponto-hypothalamic-pathway-in-the-human-brain
#15
Arash Kamali, Niloofar Karbasian, Pejman Rabiei, Andres Cano, Roy F Riascos, Nitin Tandon, Octavio Arevalo, Laura Ocasio, Kyan Younes, Mahsa Khayat-Khoei, Saeedeh Mirbagheri, Khader M Hasan
The cerebellum is shown to be involved in some limbic functions of the human brain such as emotion and affect. The major connection of the cerebellum with the limbic system is known to be through the cerebello-hypothalamic pathways. The consensus is that the projections from the cerebellar nuclei to the limbic system, and particularly the hypothalamus, or from the hypothalamus to the cerebellar nuclei, are through multisynaptic pathways in the bulbar reticular formation. The detailed anatomy of the pathways responsible for mediating these responses, however, is yet to be determined...
April 16, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29672420/the-arrival-of-robotics-in-spine-surgery-a-review-of-the-literature
#16
Alexander Ghasem, Akhil Sharma, Dylan N Greif, Milad Alam, Motasem Al Maaieh
STUDY DESIGN: Systematic Review. OBJECTIVE: The authors aim to review comparative outcome measures between robotic and free-hand spine surgical procedures including: accuracy of spinal instrumentation, radiation exposure, operative time, hospital stay, and complication rates. SUMMARY OF BACKGROUND DATA: Misplacement of pedicle screws in conventional open as well as minimally invasive surgical procedures has prompted the need for innovation and allowed the emergence of robotics in spine surgery...
April 18, 2018: Spine
https://www.readbyqxmd.com/read/29670988/reducing-complications-and-overall-healthcare-costs-of-hip-fracture-management-a-retrospective-study-on-the-application-of-a-diagnostic-therapeutic-pathway-in-the-cosenza-general-hospital
#17
M Loizzo, F Gallo, D Caruso
BACKGROUND: Diagnostic Therapeutic Pathways (DTPs) are multidisciplinary plans designed by each healthcare organization for a specific category of patients to reduce the variability of professional behaviors and to ensure greater safety and better overall healthcare outcomes. Hip fractures are a frequent traumatic injury, particularly in the elderly, and DTPs recommend early surgical intervention, often not done due to organizational challenges and bureaucracy. Medical conditions suggesting a delay are not frequent, however long waiting times not only increase the risk of complications and mortality, but also increase the number of diagnostic test and physician consultations...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29670868/characteristics-of-patients-with-colonic-polyps-requiring-segmental-resection
#18
Robert A Mitchell, Chaoran Zhang, Cherry Galorport, Blair Walker, Jennifer Telford, Robert Enns
Background: It is unclear if the availability of new techniques for removal of large colonic polyps has affected the use of segmental colon resection. We sought to evaluate the characteristics of polyps undergoing surgical resection, including involvement of therapeutic gastroenterologists (TG). Methods: 484 patients had a colonic resection; 165 (34%) were identified from the pathology database with polyp, adenoma, or mass in the clinical history field; these charts were reviewed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29670108/down-regulation-of-a-pro-apoptotic-pathway-regulated-by-pcaf-ada3-in-early-stage-gastric-cancer
#19
Daniella Brasacchio, Rita A Busuttil, Tahereh Noori, Ricky W Johnstone, Alex Boussioutas, Joseph A Trapani
The loss of p300/CBP-associated protein (PCAF) expression is associated with poor clinical outcome in gastric cancer, and a potential bio-marker for invasive and aggressive tumors. However, the mechanism linking loss of PCAF to the onset of gastric cancer has not been identified. Given that PCAF and its binding partner transcriptional adaptor protein 3 (ADA3) were recently shown to regulate the intrinsic (mitochondrial) pathway to apoptosis via epigenetic regulation of phosphofurin acidic cluster sorting proteins 1 and 2 (PACS1, PACS2), we analyzed PCAF, ADA3, and PACS1/2 expression in 99 patient-matched surgical samples ranging from normal gastric mucosa, through pre-malignant chronic gastritis and intestinal metaplasia to stage I-III invasive cancers...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29668935/systematic-review-of-diagnostic-pathways-for-patients-presenting-with-acute-abdominal-pain
#20
Kirsten J de Burlet, Andrew J Ing, Peter D Larsen, Elizabeth R Dennett
Purpose: Abdominal pain is the most common reason for surgical referral. Imaging, aids early diagnosis and treatment. However unnecessary requests are associated with increased costs, radiation exposure and increased length of stay. Pathways can improve the quality of the diagnostic process. The aim of this systematic review was to identify the current evidence for diagnostic pathways and their use of imaging and effect on final outcomes. Data sources: A systematic search of Embase, Medline and Cochrane databases was performed using keywords and MeSH terms for abdominal pain...
April 13, 2018: International Journal for Quality in Health Care
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