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https://www.readbyqxmd.com/read/29232645/pre-optimization-of-spinal-surgery-patients-development-of-a-neurosurgical-enhanced-recovery-after-surgery-eras-protocol
#1
Zarina S Ali, Tracy S Ma, Ali K Ozturk, Neil R Malhotra, James M Schuster, Paul J Marcotte, M Sean Grady, William C Welch
OBJECTIVE: Despite surgical, technological, medical, and anesthetic improvements, patient outcomes following elective neurosurgical procedures can be associated with high morbidity. Enhanced recovery after surgery (ERAS) protocols are multimodal care pathways designed to optimize patient outcomes by addressing pre-, peri-, and post-operative factors. Despite significant data suggesting improved patient outcomes with the adoption of these pathways, development and implementation has been limited in the neurosurgical population...
December 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29230415/hypoxia-induces-apoptosis-through-hif-1%C3%AE-signaling-pathway-in-human-uterosacral-ligaments-of-pelvic-organ-prolapse
#2
Xinrui Zhao, Congcong Ma, Rui Li, Jing Xue, Lidong Liu, Peishu Liu
The purpose of this study is to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) in women uterosacral ligament tissues with pelvic organ prolapse and women with normal uterine support structures and illuminate its relationship with apoptosis. Samples were collected from 38 women with pelvic organ prolapse and 31 age matched controls. The expression levels of HIF-1α and BNIP3 in the uterosacral ligaments were measured using immunohistochemistry, qRT-PCR, and Western blot. To assess apoptosis we performed TUNEL assay and Western blot analyses...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230096/fibroblast-growth-factor-receptor-2-fgfr2-mutation-related-syndromic-craniosynostosis
#3
REVIEW
Saïd C Azoury, Sashank Reddy, Vivek Shukla, Chu-Xia Deng
Craniosynostosis results from the premature fusion of cranial sutures, with an incidence of 1 in 2,100-2,500 live births. The majority of cases are non-syndromic and involve single suture fusion, whereas syndromic cases often involve complex multiple suture fusion. The fibroblast growth factor receptor 2 (FGFR2) gene is perhaps the most extensively studied gene that is mutated in various craniosynostotic syndromes including Crouzon, Apert, Pfeiffer, Antley-Bixler, Beare-Stevenson cutis gyrata, Jackson-Weiss, Bent Bone Dysplasia, and Seathre-Chotzen-like syndromes...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29229746/inhibition-of-nadph-oxidase-dependent-oxidative-stress-in-the-rostral-ventrolateral-medulla-mediates-the-antihypertensive-effects-of-acupuncture-in-spontaneously-hypertensive-rats
#4
Xue-Rui Wang, Jing-Wen Yang, Cai-Shuo Ji, Xiang-Hong Zeng, Guang-Xia Shi, Marc Fisher, Cun-Zhi Liu
Oxidative stress in the rostral ventrolateral medulla (RVLM), where the sympathetic nervous control center is located, contributes to neural mechanisms of hypertension. Acupuncture was previously reported to favorably affect high blood pressure. However, little is known about the effect of acupuncture on oxidative stress-modulated mechanisms in hypertension. This study was designed to evaluate the hypothesis that acupuncture exerts an antihypertensive effect via ameliorating oxidative stress and the redox-sensitive pathway in the RVLM of spontaneously hypertensive rats...
December 11, 2017: Hypertension
https://www.readbyqxmd.com/read/29229342/parahippocampectomy-as-a-new-surgical-approach-to-mesial-temporal-lobe-epilepsy-due-to-hippocampal-sclerosis-a-pilot-randomized-comparative-clinical-trial
#5
Mario Arturo Alonso-Vanegas, Iván D Freire Carlier, Daniel San-Juan, Alma Rosa Martínez NPsych, Carlos Trenado
BACKGROUND AND OBJECTIVE: The parahippocampal gyrus (PHG) plays an important role in the epileptogenic pathways of mTLE-HS, it´s resection could be preventing epileptic seizures with less complications. Evaluate the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalo-hipppocampectomy (SAH) and parahippocampectomy (PHC) surgical approaches in mTLE-HS. METHODS: This was a randomized comparative pilot clinical trial (2008-2011) that included patients with mTLE-HS who underwent: ATL, trans-T3 SAH, and trans-T3 PHC...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29227567/the-dog-is-a-model-for-the-study-of-human-hip-dysplasia
#6
Cecilia Pascual-Garrido, Farshid Guilak, Muhammad Farooq Rai, Michael D Harris, Mandi J Lopez, Rory J Todhunter, John C Clohisy
Developmental dysplasia of the hip (DDH) in humans is a common condition that is associated with hip pain, functional limitations, and secondary osteoarthritis (OA). Surgical treatment of DDH has improved in the last decade, allowing excellent outcomes at short- and mid-term follow-up. Still, the etiology, mechanobiology, and pathology underlying this disease are not well understood. A pre-clinical animal model of DDH could help advance the field with a deeper understanding of specific pathways that initiate hip joint degeneration secondary to abnormal biomechanics...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29225618/influence-of-enhanced-recovery-pathway-on-surgical-site-infection-after-colonic-surgery
#7
Caroline Gronnier, Fabian Grass, Christiane Petignat, Basile Pache, Dieter Hahnloser, Giorgio Zanetti, Nicolas Demartines, Martin Hübner
Background: The present study aimed to evaluate a potential effect of ERAS on surgical site infections (SSI). Methods: Colonic surgical patients operated between May 2011 and September 2015 constituted the cohort for this retrospective analysis. Over 100 items related to demographics, surgical details, compliance, and outcome were retrieved from a prospectively maintained database. SSI were traced by an independent National surveillance program. Risk factors for SSI were identified by univariate and multinomial logistic regression...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29224789/pediatric-surgical-capacity-building-a-pathway-to-improving-access-to-pediatric-surgical-care-in-haiti
#8
Neema Kaseje, Hillary Jenny, Andre Patrick Jeudy, Jean Louis MacLee, John G Meara, Henri R Ford
PURPOSE: Lack of human resources is a major barrier to accessing pediatric surgical care globally. Our aim was to establish a model for pediatric surgical training of general surgery residents in a resource constrained region. MATERIALS/METHODS: A pediatric surgical program with a pediatric surgical rotation for general surgery residents in a tertiary hospital in Haiti in 2015 was established. We conducted twice daily patient rounds, ran an outpatient clinic, and provided emergent and elective pediatric surgical care, with tasks progressively given to residents until they could run clinic and perform the most common elective and emergent procedures...
November 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223673/risk-stratification-in-pediatric-perforated-appendicitis-prospective-correlation-with-outcomes-and-resource-utilization
#9
Yasmine Yousef, Fouad Youssef, Trish Dinh, Kartikey Pandya, Hayden Stagg, Michael Homsy, Robert Baird, Jean-Martin Laberge, Dan Poenaru, Pramod Puligandla, Kenneth Shaw, Sherif Emil
PURPOSE: Despite a wide spectrum of severity, perforated appendicitis in children is typically considered a single entity in outcomes studies. We performed a prospective cohort study to define a risk stratification system that correlates with outcomes and resource utilization. METHODS: A prospective study was conducted of all children operated for perforated appendicitis between May 2015 and December 2016 at a tertiary free-standing university children's hospital...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29223630/postoperative-loss-of-midline-function-in-brachial-plexus-birth-palsy
#10
Dustin A Greenhill, Arianna Trionfo, Frederick V Ramsey, Scott H Kozin, Dan A Zlotolow
PURPOSE: To identify the rate of and predictive variables for functionally limited shoulder internal rotation in postoperative patients with brachial plexus birth palsy. METHODS: Records of patients with brachial plexus birth palsy who had surgery on the affected upper extremity during a 10-year period were retrospectively reviewed. Patient demographics, physical examinations, and all upper extremity procedures were recorded. Loss of midline function (LOM) was defined as a Modified Mallet Scale or Active Movement Scale (AMS) internal rotation score <3...
December 6, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29222517/input-dependent-regulation-of-excitability-controls-dendritic-maturation-in-somatosensory-thalamocortical-neurons
#11
Laura Frangeul, Vassilis Kehayas, Jose V Sanchez-Mut, Sabine Fièvre, K Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes Gräff, Jeffrey D Macklis, Denis Jabaudon
Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. Here, using genetic and surgical manipulations of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitability is a critical component of dendritic development. Using a combination of genetic approaches, we find that ablation of N-methyl-D-aspartate (NMDA) receptors during postnatal development leads to epigenetic repression of Kv1...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222259/controversies-in-venous-thromboembolism-to-treat-or-not-to-treat-superficial-vein-thrombosis
#12
REVIEW
Jan Beyer-Westendorf
The management of superficial vein thrombosis (SVT) is poorly defined and remains controversial overall. SVT has long been considered a benign, self-limited disease, but recent studies show that SVT carries a nonnegligible risk for recurrence, deep vein thrombosis, or pulmonary embolism. Current guidelines recommend the use of low-molecular-weight heparin or fondaparinux, but results of several surveys indicate that the majority of patients with SVT receive nonanticoagulant therapy only, which includes compression stockings or bandages, nonsteroidal anti-inflammatory drugs, topical application of heparin gel, or surgical interventions...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29218667/the-novel-trial-natural-orifice-versus-laparoscopic-cholecystectomy-a-prospective-randomized-evaluation
#13
Steven D Schwaitzberg, Kurt Roberts, John R Romanelli, David J Desilets, David Earle, Santiago Horgan, Lee Swanstrom, Eric Hungness, Nathaniel Soper, Michael L Kochman
INTRODUCTION: The evolution of Natural Orifice Translumenal Endoscopic Surgery® (NOTES®) represents a case study in surgical procedural evolution. Beginning in 2004 with preclinical feasibility studies, and followed by the creation of the NOSCAR® collaboration between The Society of American Gastrointestinal and Endoscopic Surgeons and the American Society for Gastrointestinal Endoscopy, procedural development followed a stepwise incremental pathway. The work of this consortium has included white paper analyses, obtaining outside independent funding for basic science and procedural development, and, ultimately, the initiation of a prospective randomized clinical trial comparing NOTES® cholecystectomy as an alternative procedure to laparoscopic cholecystectomy...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29216689/-doxycycline-as-an-adjuvant-in-postsurgical-recovery-of-rotator-cuff-injuries-one-year-follow-up
#14
J I Díaz-Sanabria, C Trueba-Vasavilbaso, F Gil-Orbezo, C Trueba-Davalillo, M Acuña-Tovar
BACKGROUND: The severity and progression of rotator cuff tears have forced research on new treatment pathways such as metalloprotease inhibition, which has shown a reduction in healing time and improvement in the structure of collagen fibers. OBJECTIVE: To evaluate the use of doxycycline as a healing enhancer in rotator cuff tears after surgical treatment. MATERIAL AND METHODS: 20 patients were included; they were divided into two groups, 10 with the use of doxycycline and 10 without it after arthroscopic repair with one-year follow-up...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29212066/fstl1-promotes-glioma-growth-through-the-bmp4-smad1-5-8-signaling-pathway
#15
Xin Jin, Er Nie, Xu Zhou, Ailiang Zeng, Tianfu Yu, Tongle Zhi, Kuan Jiang, Yingyi Wang, Junxia Zhang, Yongping You
BACKGROUND: Gliomas result in the highest morbidity and mortality rates of intracranial primary central nervous system tumors because of their aggressive growth characteristics and high postoperative recurrence. They are characterized by genetic instability, intratumoral histopathological variability and unpredictable clinical behavior in patients. Proliferation is a key aspect of the clinical progression of malignant gliomas, complicating complete surgical resection and enabling tumor regrowth and further proliferation of the surviving tumor cells...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29210294/current-and-future-therapeutic-approaches-for-osteosarcoma
#16
Douglas J Harrison, David S Geller, Jonathan D Gill, Valerae O Lewis, Richard Gorlick
Current treatment of osteosarcoma includes surgical resection of all gross disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This yields a 5-year event free survival (EFS) of approximately 70% for patients with localized osteosarcoma while patients with metastatic or recurrent disease fare poorly with overall survival rates of less than 20%. Areas covered: This review outlines the current and future approach towards the treatment of osteosarcoma. A literature search was performed utilizing PubMed...
December 6, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29209515/ketogenic-diets-as-an-adjuvant-therapy-in-glioblastoma-the-keating-trial-study-protocol-for-a-randomised-pilot-study
#17
Kirsty J Martin-McGill, Anthony G Marson, Catrin Tudur Smith, Michael D Jenkinson
Background: Glioblastoma is the commonest form of malignant brain tumour in adults, affecting 2-3 people per 100,000 per year. Despite current treatment options including surgical resection, radiotherapy and temozolomide chemotherapy, overall survival at 2 years is approximately 27%, with a median survival of 12-14 months. The ketogenic diet (KD) is postulated to work by simulating the metabolic response to fasting by promoting the utilisation of ketones as a primary energy source, and depriving the glycolytic pathways utilised by malignant glioma cells for growth...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29208525/novel-familial-mutation-of-lrp5-causing-high-bone-mass-genetic-analysis-clinical-presentation-and-characterization-of-bone-matrix-mineralization
#18
K M Roetzer, G Uyanik, A Brehm, J Zwerina, S Zandieh, T Czech, P Roschger, B M Misof, K Klaushofer
The Wnt signalling pathway is a critical regulator of bone mass and quality. Several heterozygous mutations in the LRP5 gene, a Wnt co-receptor, causing high bone mass (LRP5-HBM) have been described to date. The pathogenic mechanism is thought to be a gain-of-function caused by impaired inhibition of the canonical Wnt signalling pathway, thereby leading to increased bone formation. We report the cases of two affected family members, a 53-year-old mother and her 23-year-old daughter, with high bone mass (T-scores mother: lumbar spine 11...
December 5, 2017: Bone
https://www.readbyqxmd.com/read/29207533/molecular-and-genetic-determinants-of-glioma-cell-invasion
#19
REVIEW
Kenta Masui, Yoichiro Kato, Tatsuo Sawada, Paul S Mischel, Noriyuki Shibata
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation. Recently updated classification of diffuse gliomas based on distinct genetic and epigenetic features has culminated in a multilayered diagnostic approach to combine histologic phenotypes and molecular genotypes in an integrated diagnosis. However, it is still a work in progress to decipher how the genetic aberrations contribute to the aggressive nature of gliomas including their highly invasive capacity...
December 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29206676/hepatobiliary-hands-of-hopkins
#20
Henry A Pitt
OBJECTIVE: This historical perspective documents the role that John L. Cameron played in advancing hepatobiliary research, education, and surgery at Johns Hopkins in the 1970s, 1980s, and 1990s. SUMMARY OF BACKGROUND DATA: Dating back to William S. Halsted in the 19th century, leaders of the Department of Surgery at Johns Hopkins have been interested in hepatobiliary disease and surgery. John L. Cameron had broad hepato-pancreato-biliary (HPB) interests when he completed his surgical training...
December 4, 2017: Annals of Surgery
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