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Surgery Tumour Markers

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https://www.readbyqxmd.com/read/29628799/clinical-and-immunological-correlates-of-long-term-survival-in-glioblastoma
#1
REVIEW
Bartosz Czapski, Szymon Baluszek, Christel Herold-Mende, Bozena Kaminska
Glioblastoma (GBM) is the most common and most aggressive type of primary brain tumour in adults. It represents 54% of all gliomas and 16% of all brain tumours (Ostrom et al. 2016). Despite surgery and treatment with radiotherapy plus an oral alkylating agent, temozolomide (TMZ), tumours invariably recur, and the patient survival is an average of ~14-16 months. In this review we summarise the current understanding of multiple factors that may affect survival of patients with GBMs. In particular, we discuss recent advancements in surgery and detection of genomic-based markers with prognostic values, such as IDH1/2 mutations, MGMT gene promoter methylation, and TERT gene promoter alterations...
March 2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29593061/biomarkers-of-chondrosarcoma
#2
REVIEW
Wonju Jeong, Ha-Jeong Kim
Clinical outcome prediction is major concern to patients with cancer. Various molecular markers in various carcinomas have been identified in the past few decades. However, accurate predictors in chondrosarcoma have not been developed, even though chondrosarcoma is the second most common primary bone tumour. Chondrosarcoma is the cartilage-forming malignancy and shows a wide spectrum of clinicopathological behaviours. The majority of chondrosarcoma grows slowly and rarely metastasises, and adequate surgery leads to a good prognosis...
March 28, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29587720/spontaneous-adrenocorticotropic-hormone-acth-normalisation-due-to-tumour-regression-induced-by-metyrapone-in-a-patient-with-ectopic-acth-syndrome-case-report-and-literature-review
#3
Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura, Junko Takagi
BACKGROUND: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case of EAS in which ACTH production by a lung tumour was reduced by metyrapone (MTP) and also reviewed previous cases of ectopic ACTH production suppressed via steroidogenesis inhibition. CASE PRESENTATION: A 71-year-old female with general fatigue, central obesity and impaired glucose tolerance was diagnosed with Cushing's syndrome due to elevated ACTH (192...
March 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29587679/activated-innate-lymphoid-cell-populations-accumulate-in-human-tumour-tissues
#4
Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong, Graham Ogg
BACKGROUND: Innate lymphoid cells (ILC) are part of a heterogeneous family of haematopoietic effector cells which lack re-arranged antigen-specific receptors. They promote host defense and contribute to tissue and metabolic homeostasis, wound healing and immune surveillance. Their role in human cancer immunity is less defined, and therefore we aimed to identify the frequency and phenotype of distinct ILC groups in various types of cancer. METHODS: Tissue samples and peripheral blood were collected from patients undergoing surgical resection of gastrointestinal and breast tumours...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29560280/micro-rnas-are-involved-in-activation-of-epicardium-during-zebrafish-heart-regeneration
#5
Marcello Ceci, Claudia Carlantoni, Maria Azzurra Missinato, Davide Bonvissuto, Bruna Di Giacomo, Riccardo Contu, Nicla Romano
Zebrafish could be an interesting translational model to understand and improve the post-infarction trial and possible regeneration in humans. The adult zebrafish is able to regenerate efficiently after resecting nearly 20% of the ventricular apex. This process requires the concert activation of the epicardium and endocardium, as well as trans-differentiation of pre-existing cardiomyocytes that together replace the lost tissue. The molecular mechanisms involved in this activation process are not completely clarified...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29552627/primary-small-cell-ovarian-cancer-of-pulmonary-type-a-case-report
#6
Emmanouil Kalampokas, Vijay Sharma, Tanja Gagliardi, Fiona Payne, Mahalakshmi Gurumurthy
Background: Primary small cell ovarian cancer of pulmonary type (SCCOPT) is a rare aggressive ovarian tumour with an incidence of <1%, usually occurring in perimenopausal or postmenopausal women and known to have a poor prognosis. Current treatment is platinum based but has not resulted in long term survival. Case presentation: We report a case of a 77-year old Caucasian woman who presented initially with a one-week history of abdominal discomfort with raised inflammatory markers and Ca125 of 50 μ/ml...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29551004/feasibility-of-fluorescence-lymph-node-imaging-in-colon-cancer-flicc
#7
M Chand, D S Keller, H M Joshi, L Devoto, M Rodriguez-Justo, R Cohen
BACKGROUND: In colon cancer, appropriate tumour excision and associated lymphadenectomy directly impact recurrence and survival outcomes. Currently, there is no standard for mesenteric lymphadenectomy, with a lymph node yield of 12 acting as a surrogate quality marker. Our goal was to determine the safety and feasibility of indocyanine green (ICG) fluorescence imaging to demonstrate lymphatic drainage in colon cancer in a dose-escalation study. METHODS: A prospective pilot study of colon cancer patients undergoing curative laparoscopic resection was performed...
March 17, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29525758/atrial-myxoma-presenting-as-infective-endocarditis
#8
Gerald Paul Fitzgerald, John Joseph Coughlan, Zahir Satti, Samer Arnous
A 23-year-old Asian student presented to our service with a 1-month history of fever, weight loss of 10 kg, night sweats, fatigue and general malaise. He was previously well with no significant medical or family history. He had a low-grade pyrexia and cardiac auscultation revealed a diastolic murmur consistent with 'tumour plop'. He had no sequelae of endocarditis. He had low-grade pyrexia of 37.7°C, and ECG showed sinus tachycardia at 130 bpm. He had raised inflammatory markers and was started on broad spectrum antibiotics...
March 9, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29519176/stress-response-to-ovariohysterectomy-in-rabbits-role-of-anaesthesia-and-surgery
#9
I Chaniotakis, E Antoniou, N Kostomitsopoulos, S Karapsias, P Mirilas, C Salakos
The aim of this study was to evaluate the neuroendocrine and inflammation response to laparoscopic total ovariohysterectomy (TOH) in rabbits, by comparing surgical stress markers of laparoscopic group with those of conventional open ovariohysterectomy and open ovariohysterectomy with pre-incisional local anaesthesia groups. Blood was sampled from 18 rabbits, of which six underwent laparoscopic TOH, six conventional open TOH and six conventional open TOH with pre-incisional local anaesthesia, 30 min before induction of anaesthesia (T0), immediately after skin incision (T1), 90 min postoperatively (T2), and 24 h postoperatively (T3)...
March 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29490961/extent-and-cost-of-inappropriate-use-of-tumour-markers-in-patients-with-pulmonary-disease-a-multicentre-retrospective-study-in-shanghai-china
#10
Haichen Zhang, Yunxiao Song, Xiong Zhang, Jun Hu, Suwei Yuan, Jin Ma
OBJECTIVES: The currently implemented healthcare reform in China requires substantial capital investment. Although overtreatment results in serious waste, inappropriate laboratory use is widespread, and overuse of tumour markers (TMs) has attracted increasing attention. DESIGN: Retrospective study. SETTING: The respiratory, thoracic surgery and oncology departments of three hospitals in Shanghai from 2014 to 2015. PARTICIPANTS: Patients with chronic obstructive pulmonary disease (COPD) and primary bronchogenic lung cancer (PLC)...
February 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29476662/new-clinicopathological-associations-and-histoprognostic-markers-in-ilae-types-of-hippocampal-sclerosis
#11
Ana Laura Calderon-Garcidueñas, Bertrand Mathon, Pierre Lévy, Anne Bertrand, Karima Mokhtari, Véronique Samson, Valérie Thuriès, Virginie Lambrecq, Vi-Huong Michel Nguyen, Sophie Dupont, Claude Adam, Michel Baulac, Stéphane Clémenceau, Charles Duyckaerts, Vincent Navarro, Franck Bielle
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a heterogeneous syndrome. Surgery results in seizure freedom for most pharmacoresistant patients, but the epileptic and cognitive prognosis remains variable. The 2013 International League Against Epilepsy (ILAE) histopathological classification of hippocampal sclerosis (HS) has fostered research to understand MTLE-HS heterogeneity. We investigated the associations between histopathological features (ILAE types, hypertrophic CA4 neurons, granule cell layer alterations, CD34 immunopositive cells) and clinical features (presurgical history, postsurgical outcome) in a monocentric series of 247 MTLE-HS patients treated by surgery...
February 24, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29474318/fibroblastic-malignant-peripheral-nerve-sheath-tumour-of-the-uterine-cervix-report-of-a-case-and-literature-review-with-emphasis-on-possible-differential-diagnosis
#12
Valentina Sangiorgio, Vanna Zanagnolo, Giovanni Aletti, Luca Bocciolone, Simone Bruni, Fabio Landoni, Nicoletta Colombo, Angelo Maggioni, Enzo Ricciardi
Cervical sarcomas are rare neoplasms, accounting for <1% of all cervical malignancies and characterized by an aggressive course despite radical excision. We report the clinical and microscopic features of a spindle cell sarcoma arising as a polypoid endocervical mass in a 45-yr-old woman. The neoplasm was characterized by a monotonous, mildly atypical proliferation of spindle cells, displaying a fibrosarcoma-like parallel pattern of highly dense fascicles, growing under the cervical epithelium. Mitotic activity was conspicuous, with up to 40 mitoses per 10 HPF...
February 22, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29458792/circulating-tumour-dna-a-promising-biomarker-for-the-management-of-colorectal-cancer
#13
REVIEW
Shelize Khakoo, Alexandros Georgiou, Marco Gerlinger, David Cunningham, Naureen Starling
Circulating cell free tumour DNA (ctDNA) maintains the same genomic alterations that are present in the corresponding tumour, thereby allowing for quantitative and qualitative real-time evaluation in body fluids as an alternative to onerous repeat biopsies. Improvements in the sensitivity of techniques used to identify ctDNA has led to a surge of research investigating its role in the detection of: early disease, relapse, response to therapy and emerging drug resistance mechanisms. Following curative surgery, ctDNA detection is a promising marker of minimal residual disease and could better select patients for adjuvant chemotherapy...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29449673/the-predictive-and-prognostic-potential-of-plasma-telomerase-reverse-transcriptase-tert-rna-in-rectal-cancer-patients
#14
Enrica Rampazzo, Paola Del Bianco, Roberta Bertorelle, Caterina Boso, Alessandro Perin, Giovanna Spiro, Francesca Bergamo, Claudio Belluco, Angela Buonadonna, Elisa Palazzari, Sara Leonardi, Antonino De Paoli, Salvatore Pucciarelli, Anita De Rossi
BACKGROUND: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable. The current study aimed to investigate the effectiveness of plasma telomerase reverse transcriptase (TERT) levels in predicting tumour response and clinical outcome. METHODS: 176 rectal cancer patients were included. Plasma samples were collected at baseline (before CRT=T0), 2 weeks after CRT was initiated (T1), post-CRT and before surgery (T2), and 4-8 months after surgery (T3) time points...
February 15, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29428550/a-new-model-to-predict-benign-histology-in-residual-retroperitoneal-masses-after-chemotherapy-in-nonseminoma
#15
Ricardo Leão, Madhur Nayan, Nahid Punjani, Michael A S Jewett, Kamel Fadaak, Juan Garisto, Jeremy Lewin, Eshetu G Atenafu, Joan Sweet, Lynn Anson-Cartwright, Peter Boström, Peter Chung, Padraig Warde, Philippe L Bedard, Aditya Bagrodia, Yuval Freifeld, Nicholas Power, Eric Winquist, Robert J Hamilton
BACKGROUND: Postchemotherapy retroperitoneal lymph node dissection (pcRPLND) is indicated in testicular cancer patients with normalised or plateaued serum tumour markers and residual retroperitoneal lesions >1cm. Challenges remain in predicting postchemotherapy residual mass (pcRM) histology, which may lead to unnecessary surgery. OBJECTIVE: To develop an accurate model to predict pcRM histology in patients with nonseminomatous germ cell tumours (NSGCTs). DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of 335 patients undergoing pcRPLND for metastatic NSGCTs to develop a model to predict benign histology in retroperitoneal pcRM...
February 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29396855/use-of-a-novel-1-hour-protocol-for-rapid-frozen-section-immunocytochemistry-in-a-case-of-squamous-cell-carcinoma-treated-with-mohs-micrographic-surgery
#16
K Sinha, F Ali, G Orchard, W Rickaby, M Shams, R Mallipeddi, R Patalay
For squamous cell carcinoma (SCC) treated using Mohs micrographic surgery (MMS), interpretation of haematoxylin and eosin-stained frozen sections can be challenging. In these situations, ancillary use of immunostaining is a useful tool for the Mohs surgeon. However, use of immunostaining in MMS laboratories is limited, mainly because current manual immunostaining platforms are subject to operator error, and automated immunostaining, albeit accurate, is too slow for inclusion in MMS. In this report, we describe a novel 1-hour protocol for rapid frozen section immunocytochemistry, using the pancytokeratin markers AE1/AE3...
February 3, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29365058/colorectal-cancer-crc-monitoring-by-six-monthly-18fdg-pet-ct-an-open-label-multicentre-randomised-trial
#17
I Sobhani, E Itti, A Luciani, I Baumgaertner, R Layese, T André, M Ducreux, J-M Gornet, G Goujon, T Aparicio, J Taieb, J-B Bachet, F Hemery, A Retbi, M Mons, R Flicoteaux, B Rhein, S Baron, I Cherrak, P Rufat, P Le Corvoisier, N De'Angelis, P-A Natella, H Maoulida, C Tournigand, I Durand Zaleski, S Bastuji-Garin
Background: 18FDG-PET/CT has high sensitivity for detecting recurrences of colorectal cancer (CRC). Our objective was to determine whether adding routine 6-monthly 18FDG-PET/CT to our usual monitoring strategy improved patient outcomes and to assess the effect on costs. Patients and Methods: In this open-label multicentre trial, patients in remission of CRC (stage II perforated, stage III, or stage IV) after curative surgery were randomly assigned (1:1) to usual monitoring alone (3-monthly physical and tumour marker assays, 6-monthly liver ultrasound and chest radiograph, and 6-monthly whole-body computed tomography) or with 6-monthly 18FDG-PET/CT, for 3 years...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29343995/humanmethylation450k-array-identified-biomarkers-predict-tumour-recurrence-progression-at-initial-diagnosis-of-high-risk-non-muscle-invasive-bladder-cancer
#18
Mark O Kitchen, Richard T Bryan, Richard D Emes, Christopher J Luscombe, K K Cheng, Maurice P Zeegers, Nicholas D James, Lyndon M Gommersall, Anthony A Fryer
Background: High-risk non-muscle invasive bladder cancer (HR-NMIBC) is a clinically unpredictable disease. Despite clinical risk estimation tools, many patients are undertreated with intra-vesical therapies alone, whereas others may be over-treated with early radical surgery. Molecular biomarkers, particularly DNA methylation, have been reported as predictive of tumour/patient outcomes in numerous solid organ and haematologic malignancies; however, there are few reports in HR-NMIBC and none using genome-wide array assessment...
2018: Biomarkers in Cancer
https://www.readbyqxmd.com/read/29334118/markers-of-proliferation-and-invasiveness-in-somatotropinomas
#19
Agata Baldys-Waligorska, Iga Wierzbicka, Grzegorz Sokolowski, Dariusz Adamek, Filip Golkowski
IntroductionIn the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein) and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and MethodsWe retrospectively studied a group of 31 patients who underwent pituitary tumour surgery. Expression of Ki-67, TOPO 2A, AIP and VEGF in surgical specimens was determined by immunohistochemistry. Relations between quantitatively determined markers and clinical symptoms, tumour features, and MR imaging, were analysed...
January 15, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29299820/malignant-transformation-in-non-functioning-pituitary-adenomas-pituitary-carcinoma
#20
REVIEW
Nèle Lenders, Ann McCormack
Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. These are a histologically heterogenous group of tumours, comprising gonadotroph, null cell, "silent" tumours of corticotroph, somatotroph or lactotroph cell lineages as well as plurihormonal Pit-1 tumours. NFPC are exceedingly rare, and hence few cases have been described. This review has identified 38 patients with NFPC reported in the literature...
April 2018: Pituitary
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