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Surgery Tumour Markers

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https://www.readbyqxmd.com/read/28729185/-testicular-tumours-in-children-indications-for-testis-sparing-surgery
#1
Martha Isabel Romo Muñoz, Vanesa Núñez Cerezo, Mariela Dore Reyes, Alejandra Vilanova Sánchez, Pilar González-Peramato, Pedro López Pereira, María José Martínez Urrutia
INTRODUCTION AND OBJECTIVES: Although standard surgical treatment of a testicular tumour is orchiectomy, use can be made of testis-sparing surgery in selected cases, based on tumour markers, tumour size, and histopathological findings. Our objective is to become acquainted with the indications of testis-sparing surgery as a treatment for the incidental finding of a palpable and non-palpable testicular mass. MATERIAL AND METHODS: A retrospective study was conducted on 22 patients younger than 18 years diagnosed with a testicular tumour between 2000 and 2014...
July 17, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28696209/hashimoto-s-thyroiditis-predicts-outcome-in-intrathyroidal-papillary-thyroid-cancer
#2
Vincenzo Marotta, Concetta Sciammarella, Maria Grazia Chiofalo, Claudio Gambardella, Claudio Bellevicine, Marica Grasso, Giovanni Conzo, Giovanni Docimo, Gerardo Botti, Nunzia Simona Losito, Giancarlo Troncone, Maurizio De Palma, Laura Giacomelli, Luciano Pezzullo, Annamaria Al Colao, Antongiulio Faggiano
Hashimoto's thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analyzing all disease stages. Given that HT-related microenvironment involves solely the thyroid, we aimed to assess relationship between HT, as detected through pathological assessment, and outcome in intrathyroidal PTC. This was a multicenter, retrospective, observational study including 301 PTC with no evidence of extrathyroidal disease. Primary study endpoint was the rate of clinical remission...
July 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28678571/therapeutical-effect-of-intrapleural-perfusion-with-hyperthermic-chemotherapy-on-malignant-pleural-effusion-under-video-assisted-thoracoscopic-surgery
#3
Xing Feng, Lucheng Zhu, Xiaoling Xiong, Hong Jiang, Zhibing Wu, Wen Meng, Yasi Xu, Shirong Zhang, Shenglin Ma
BACKGROUND: Patients with malignant pleural effusions (MPEs) have limited life expectancy. This study aims to investigate the feasibility of intrapleural perfusion with hyperthermic chemotherapy (IPHC) under video-assisted thoracoscopic surgery on MPE patients. METHODS: MPE patients were enrolled in the study and treated with IPHC. The treatment response was classified as complete response (CR, no re-accumulation of pleural fluid for 4 weeks), partial response (PR, re-accumulation above the post-IPHC level but below the pre-IPHC level for four weeks), no response (NR; re-accumulation or above the pre-IPHC level)...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28676646/identifying-the-neck-margin-status-of-ductal-adenocarcinoma-in-the-pancreatic-head-by-multiphoton-microscopy
#4
Jian Xu, Youting Chen, Hong Chen, Zhipeng Hong, Zheng Shi, Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen
Complete surgical resection is the only option for improving the survival of patients with ductal adenocarcinoma in the pancreatic head. After resection, determining the status of resection margins (RMs) is crucial for deciding on the nature of the follow-up treatment. The purpose of this study was to evaluate whether multiphoton microscopy (MPM) could be considered a reliable tool for determining the status of pancreatic neck margins by identifying tumour cells of ductal adenocarcinoma in these margins in the pancreatic head, and our results were affirmative...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28660992/all-that-glitters-on-pet-is-not-cancer-18f-deoxy-glucose-avidity-versus-tumor-biology-pituitary-incidentaloma-in-a-survivor-of-two-previous-unrelated-malignancies
#5
Dragana Miljić, Emilija Manojlović-Gačić, Milica Skender-Gazibara, Toplica Milojević, Vojislav Bogosavljević, Nebojša Kozarević, Nebojša Petrović, Marko Stojanović, Sandra Pekić, Mirjana Doknić, Milan Petakov, Vera Popović
INTRODUCTION: 18F-deoxy-glucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) is routinely used in the detection of malignant disease based on the property of malignant cells to fuel their growth and replication by increased glucose uptake. Malignant lesions are rare in the sellar region, while pituitary adenomas are the most common pathology. These are benign neoplasms with insidious onset and low proliferation activity, and therefore are only exceptionally detected by 18F-FDG PET/CT...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28658766/clinicopathological-study-of-carcinoma-of-the-ampulla-of-vater-with-special-reference-to-muc1-muc2-and-muc5ac-expression
#6
Maithili Mandar Kulkarni, Siddhi Gaurish Sinai Khandeparkar, Avinash R Joshi, Aniket Kakade, Lokesh Fegade, Ketan Narkhede
INTRODUCTION: The ampulla of Vater consists of papilla, common channel, distal common bile duct and the distal main pancreatic duct. Ampullary carcinomas arise from two different types of mucosa, reflecting their broad histomorphological spectrum. Adenocarcinomas originating in the ampulla of Vater are classified as having either 'Intestinal' or 'Pancreatobiliary' type of differentiation. Pancreatobiliary type has consistently shown a worse prognosis. Various types of mucins are distributed in normal tissues and gastrointestinal tumours...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658749/analysis-of-isocitrate-dehydrogenase-2-idh-2-activity-in-human-serum-as-a-biomarker-in-chemotherapy-patients-of-breast-carcinoma-a-case-control-study
#7
Roshni Gavel, S P Mishra, Seema Khanna, Rahul Khanna, Agni Gautam Shah
INTRODUCTION: Breast cancer represents a major public health problem in women worldwide. For many cancers, serum tumour markers play an important role in patient treatment and monitoring. Isocitrate dehydrogenase enzyme is also used as a biomarker for various types of cancer. AIM: The purpose of this study was to determine serum Isocitrate dehydrogenase-2 (IDH-2) enzyme activity in breast cancer patients (pre and post chemotherapy) and also correlate the changes in enzyme activity with stages of cancer and control groups...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28655483/the-impact-of-pre-and-post-operative-weight-loss-and-body-mass-index-on-prognosis-in-patients-with-oesophageal-cancer
#8
O Hynes, P Anandavadivelan, J Gossage, A M Johar, J Lagergren, P Lagergren
BACKGROUND: Weight loss is a cardinal symptom of oesophageal cancer and is often continued after surgery. High body mass index (BMI) is a strong risk factor for oesophageal adenocarcinoma. This study aimed to assess the impact of pre- and post-operative weight loss and BMI on long-term mortality after resection for oesophageal cancer. METHODS: This prospective and nationwide cohort study included 390 patients, operated on for oesophageal cancer in Sweden in 2001-2005 with follow-up until 2016, who responded to a questionnaire on weight history 6 months after surgery...
June 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28647399/quantitative-imaging-outperforms-molecular-markers-when-predicting-response-to-chemoradiotherapy-for-rectal-cancer
#9
Ines Joye, Annelies Debucquoy, Christophe M Deroose, Vincent Vandecaveye, Eric Van Cutsem, Albert Wolthuis, André D'Hoore, Xavier Sagaert, Mu Zhou, Olivier Gevaert, Karin Haustermans
BACKGROUND AND PURPOSE: To explore the integration of imaging and molecular data for response prediction to chemoradiotherapy (CRT) for rectal cancer. MATERIAL AND METHODS: Eighty-five rectal cancer patients underwent preoperative CRT. (18)F-FDG PET/CT and diffusion-weighted imaging (DWI) were acquired before (TP1) and during CRT (TP2) and prior to surgery (TP3). Inflammatory cytokines and gene expression were analysed. Tumour response was defined as ypT0-1N0. Multivariate models were built combining the obtained parameters...
June 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28622612/influence-of-age-and-comorbidity-on-prognosis-and-application-of-adjuvant-chemotherapy-in-elderly-japanese-patients-with-colorectal-cancer-a-retrospective-multicentre-study
#10
Tomoki Yamano, Shinichi Yamauchi, Kei Kimura, Akihito Babaya, Michiko Hamanaka, Masayoshi Kobayashi, Miki Fukumoto, Kiyoshi Tsukamoto, Masafumi Noda, Naohiro Tomita, Kenichi Sugihara
BACKGROUND: Adjuvant therapy for colorectal cancer (CRC) in patients aged ≥75 years is supported by inadequate evidence, although such patients are increasing in number worldwide. PATIENTS AND METHODS: We assessed the influence of age and comorbidities on the prognosis of CRC in elderly patients using pooled data by the Japanese Study Group for Postoperative Follow-up of Colorectal Cancer. In total, 4598 patients (3304 with colon cancer and 1294 with rectal cancer) who underwent curative surgery from 2004 to 2006 were analysed with respect to age, Charlson comorbidity score (CS), tumour marker positivity, adjuvant therapy and prognosis...
August 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28607544/analysis-of-fascin-1-in-relation-to-gleason-risk-classification-and-nuclear-ets-related-gene-status-of-human-prostate-carcinomas-an-immunohistochemical-study-of-clinically-annotated-tumours-from-the-wales-cancer-bank
#11
Matthew T Jefferies, Christopher S Pope, Howard G Kynaston, Alan R Clarke, Richard M Martin, Josephine C Adams
Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase, hormone-refractory prostate cancer. Analyses of independent samples are needed to establish the value of fascin-1 as a possible biomarker. We examined fascin-1 by immunohistochemistry in tumour specimens from the Wales Cancer Bank in comparison with nuclear-located ETS-related gene (ERG), an emerging marker for aggressive prostate cancer...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28607296/a-case-report-of-oesophageal-schwannoma-with-thoracoscopic-surgery
#12
Zhiliang Hu, Zhun He, Xianfeng Li, Chuanliang Peng, Zhen Li
Oesophageal schwannomas is a rare tumour and most commonly found incidentally or from diagnostic workup of dysphagia or dyspnoea. Most oesophageal schwannomas are benign and more frequently occurs in female than in the male. To date, <40 cases have been described in the English literature. In this study, we reported the case of a 57-year-old woman visited our hospital with the symptom of long-time dysphagia. A thoracic computed tomography demonstrated an upper oesophageal well marginated and homogeneous mass that adhered to the right wall of the oesophagus...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28558008/expression-of-anaesthetic-and-analgesic-drug-target-genes-in-excised-breast-tumour-tissue-association-with-clinical-disease-recurrence-or-metastasis
#13
C Connolly, S F Madden, D J Buggy, H C Gallagher
BACKGROUND: Retrospective analyses suggest anaesthetic-analgesics technique during cancer surgery may affect recurrence/metastasis. This could involve direct effects of anaesthetic-analgesic drugs on cancer cells. While μ-opioid receptor over-expression in lung tumours is associated with greater metastasis, other anaesthetic-analgesic receptor targets in cancer recurrence/metastasis remain unexplored. Therefore, we evaluated the association between genetic expression of anaesthetic-analgesic receptor targets and recurrence/metastasis, using a repository of breast cancer gene expression and matching clinical data...
2017: PloS One
https://www.readbyqxmd.com/read/28544764/the-effectiveness-of-interventions-to-treat-hypothalamic-obesity-in-survivors-of-childhood-brain-tumours-a-systematic-review
#14
REVIEW
K-W Wang, R Chau, A Fleming, L Banfield, S K Singh, D L Johnston, S M Zelcer, S R Rassekh, S Burrow, M Valencia, R J de Souza, L Thabane, M C Samaan
BACKGROUND: Survivors of childhood brain tumours (SCBT) are at risk of type 2 diabetes and cardiovascular diseases. Obesity is a major driver of cardiometabolic diseases in the general population, and interventions that tackle obesity may lower the risk of these chronic diseases. The goal of this systematic review was to summarize current evidence for the presence of interventions to manage obesity, including hypothalamic obesity, in SCBT. METHODS: The primary outcome of this review was the body mass index z-score change from baseline to the end of the intervention and/or follow-up...
May 22, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28537412/-solid-pseudopapillary-neoplasms-of-the-pancreas
#15
J Tesaříková, M Loveček, Č Neoral, K Vomáčková, L Bébarová, P Skalický
INTRODUCTION: Solid pseudopapillary neoplasm (SPN) is a very rare neoplasm that occurs in girls and young women in 90% of cases; the range is 779 years of age, and the median is 28 years of age. This tumour was first described by Virginia Frantz in 1959 as a papillary cystic tumour of the pancreas. METHODS: The aim of this retrospective study was to analyse the incidence of SPN in all patients with a pancreatic tumour operated at the 1st Dept. of Surgery, University Hospital Olomouc between years 2006 and 2015...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28511371/study-of-serum-total-psa-and-free-psa-as-an-oncological-marker-in-breast-tumour
#16
Elteza Tahjiba Jahir, Runi Devi, Bibhuti Bhushan Borthakur
INTRODUCTION: Breast Cancer (BC) cases are rising alarmingly all over the world and India is not an exception. This rising trend is due to an increased age at first child birth, decreased breast feeding, and the changing lifestyle mostly in urban India. With the advent of more sensitive methodologies and research works in this field, it has been suggested that Prostate Specific Antigen (PSA) plays an important role in the pathogenesis of breast cancer besides other established tumour markers...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28453703/heart-dose-exposure-as-prognostic-marker-after-radiotherapy-for-resectable-stage-iiia-b-non-small-cell-lung-cancer-secondary-analysis-of-a-randomized-trial
#17
M Guberina, W Eberhardt, M Stuschke, T Gauler, F Heinzelmann, D Cheufou, M Kimmich, G Friedel, H Schmidberger, K Darwiche, V Jendrossek, M Schuler, G Stamatis, C Pöttgen
Background: Heart exposure to ionizing irradiation can cause ischaemic heart disease. The partial heart volume receiving ≥5 Gy (heartV5) was supposed to be an independent prognostic factor for survival after radiochemotherapy for locally advanced non-small-cell lung cancer (NSCLC). But validation of the latter hypothesis is needed under the concurrent risks of lung cancer patients. Patients and methods: The ESPATUE phase III trial recruited patients with potentially operable IIIA(N2)/selected IIIB NSCLC between 01/2004 and 01/2013...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28439654/imaging-based-surrogate-markers-of-transcriptome-subclasses-and-signatures-in-hepatocellular-carcinoma-preliminary-results
#18
Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M Llovet
OBJECTIVES: In this preliminary study, we examined whether imaging-based phenotypes are associated with reported predictive gene signatures in hepatocellular carcinoma (HCC). METHODS: Thirty-eight patients (M/F 30/8, mean age 61 years) who underwent pre-operative CT or MR imaging before surgery as well as transcriptome profiling were included in this IRB-approved single-centre retrospective study. Eleven qualitative and four quantitative imaging traits (size, enhancement ratios, wash-out ratio, tumour-to-liver contrast ratios) were assessed by three observers and were correlated with 13 previously reported HCC gene signatures using logistic regression analysis...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28418343/the-use-of-human-epididymis-4-and-cancer-antigen-125-tumor-markers-in-the-benign-or-malignant-differential-diagnosis-of-pelvic-or-adnexal-masses
#19
Zehra Nihal Dolgun, Canan Kabaca, Ateş Karateke, Cem İyibozkurt, Cihan İnan, Ahmet Salih Altıntaş, Cihan Karadağ
BACKGROUND: Ovarian cancer is one of the highest mortality cancers in gynaecology. Discrimination of benign masses from malignant ones may sometimes become a challenge for the clinician since there is not a reliable tumour marker, thus some unnecessary, highly morbid operations can be performed. AIMS: To explore the efficacy of human epididymis 4 (HE 4) and cancer antigen 125 (CA 125) markers in differentiating malignant and benign pelvic masses of ovarian origin and to identify the cut-off points for those markers...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28401350/peritoneal-fluid-biomarkers-in-the-detection-of-colorectal-anastomotic-leaks-a-systematic-review
#20
REVIEW
Emma C Wright, Patricia Connolly, Mark Vella, Susan Moug
PURPOSE: Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anastomosis may aid early detection. This paper aims to review the evidence for their role in AL detection, allowing identification of targets for future research. METHODS: A systematic review was performed using PubMed, MEDLINE and Cochrane Library databases...
April 12, 2017: International Journal of Colorectal Disease
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