keyword
https://read.qxmd.com/read/38494863/cd40-stimulation-via-cd40-ligand-enhances-adenovirus-mediated-tumour-immunogenicity-including-find-me-eat-me-and-kill-me-signalling
#21
JOURNAL ARTICLE
Sedigheh Naseri, Mariela Mejia Cordova, Jessica Wenthe, Tanja Lövgren, Emma Eriksson, Angelica Loskog, Gustav J Ullenhag
Immunostimulatory gene therapy using oncolytic viruses is currently evaluated as a promising therapy for cancer aiming to induce anti-tumour immunity. Here, we investigate the capacity of oncolytic adenoviruses (LOAd) and their transgenes to induce immunogenicity in the infected tumour cells. Oncolysis and death-related markers were assessed after infection of eight human solid cancer cell lines with different LOAd viruses expressing a trimerized, membrane-bound (TMZ)-CD40L, TMZ-CD40L and 41BBL, or no transgenes...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38492281/development-and-validation-of-nomogram-models-for-predicting-postoperative-prognosis-of-early-stage-laryngeal-squamous-cell-carcinoma
#22
JOURNAL ARTICLE
Xu Juan, Huang Jiali, Liu Ziqi, Zhang Liqing, Zhou Han
BACKGROUND: We aimed to investigate the postoperative prognosis in patients with early-stage laryngeal squamous cell carcinoma (LSCC) in association with the preoperative blood markers and clinicopathological characteristics and to develop nomograms for individual risk prediction. METHODS: The clinical data of 353 patients with confirmed early-stage LSCC between 2009 and 2018 were retrospectively retrieved from the First Affiliated Hospital with Nanjing Medical University...
March 15, 2024: Current Problems in Cancer
https://read.qxmd.com/read/38490958/proteomic-analysis-of-ascitic-extracellular-vesicles-describes-tumour-microenvironment-and-predicts-patient-survival-in-ovarian-cancer
#23
JOURNAL ARTICLE
Anna Vyhlídalová Kotrbová, Kristína Gömöryová, Antónia Mikulová, Hana Plešingerová, Stanislava Sladeček, Marek Kravec, Šárka Hrachovinová, David Potěšil, Garett Dunsmore, Camille Blériot, Mathilde Bied, Jan Kotouček, Markéta Bednaříková, Jitka Hausnerová, Luboš Minář, Igor Crha, Michal Felsinger, Zbyněk Zdráhal, Florent Ginhoux, Vít Weinberger, Vitězslav Bryja, Vendula Pospíchalová
High-grade serous carcinoma of the ovary, fallopian tube and peritoneum (HGSC), the most common type of ovarian cancer, ranks among the deadliest malignancies. Many HGSC patients have excess fluid in the peritoneum called ascites. Ascites is a tumour microenvironment (TME) containing various cells, proteins and extracellular vesicles (EVs). We isolated EVs from patients' ascites by orthogonal methods and analyzed them by mass spectrometry. We identified not only a set of 'core ascitic EV-associated proteins' but also defined their subset unique to HGSC ascites...
March 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38483762/pituitary-tumours-without-distinct-lineage-differentiation-express-stem-cell-marker-sox2
#24
JOURNAL ARTICLE
Nèle F Lenders, Tanya J Thompson, Jeanie Chui, Julia Low, Warrick J Inder, Peter E Earls, Ann I McCormack
CONTEXT: The recent WHO 2022 Classification of pituitary tumours identified a novel group of 'plurihormonal tumours without distinct lineage differentiation (WDLD)'. By definition, these express multiple combinations of lineage commitment transcription factors, in a monomorphous population of cells. OBJECTIVES: To determine the expression of stem cell markers (SOX2, Nestin, CD133) within tumours WDLD, immature PIT-1 lineage and acidophil stem cell tumours, compared with committed cell lineage tumours...
March 14, 2024: Pituitary
https://read.qxmd.com/read/38482425/the-impact-of-alpha-1-antitrypsin-deficiency-alleles-on-lung-cancer-survival
#25
JOURNAL ARTICLE
José María Hernández-Pérez, Carolina Ramos-Izquierdo, Juan Marco Figueira-Gonçalves, Francisco Martínez-Bugallo, Yolanda Ramallo-Fariña, Lorenzo Pérez-Negrín
Different studies have shown that carrying an alpha-1 antitrypsin (AAT) deficiency allele is an independent risk factor for developing lung cancer (LC). However, to date, little is known regarding whether carrying a deficiency allele may be a prognostic factor in the evolution of LC. A prospective observational study was carried out which consecutively included patients diagnosed with LC in University Hospital "Nuestra Señora de Candelaria" between December 2017 and August 2020. A blood sample was taken from each of the patients in order to determine both AAT serum concentration and genotype...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38481388/integrating-single-cell-and-spatial-transcriptomes-reveals-col4a1-2-facilitates-the-spatial-organisation-of-stromal-cells-differentiation-in-breast-phyllodes-tumours
#26
JOURNAL ARTICLE
Xia Li, Xuewen Yu, Jiaxin Bi, Xu Jiang, Lu Zhang, Zhixin Li, Mumin Shao
BACKGROUND: Breast phyllodes tumours (PTs) are a unique type of fibroepithelial neoplasms with metastatic potential and recurrence tendency. However, the precise nature of heterogeneity in breast PTs remains poorly understood. This study aimed to elucidate the cell subpopulations composition and spatial structure and investigate diagnostic markers in the pathogenesis of PTs. METHODS: We applied single-cell RNA sequencing and spatial transcriptomes on tumours and adjacent normal tissues for integration analysis...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38481180/predictive-effect-of-the-systemic-inflammation-response-index-siri-on-the-efficacy-and-prognosis-of-neoadjuvant-chemoradiotherapy-in-patients-with-locally-advanced-rectal-cancer
#27
JOURNAL ARTICLE
Yuanyi Ding, Zining Liu, Jing Li, Wenbo Niu, Chenhui Li, Bin Yu
BACKGROUND: Inflammation is a part of tumours, and inflammatory cells can affect the proliferation, invasion, and development of tumour cells. An increasing number of peripheral blood inflammatory markers have been found to play very important roles in the treatment and prognosis of cancer patients. The systemic inflammatory response index (SIRI) is a newer inflammatory marker, and its role in colorectal cancer, especially in locally advanced rectal cancer, is still unclear. METHODS: From 2015 to 2020, 198 patients with locally advanced rectal cancer (LARC) who underwent surgery following neoadjuvant chemoradiotherapy (Neo-CRT) were analysed...
March 13, 2024: BMC Surgery
https://read.qxmd.com/read/38480935/single-cell-rna-sequencing-analysis-of-vestibular-schwannoma-reveals-functionally-distinct-macrophage-subsets
#28
JOURNAL ARTICLE
Paramita Baruah, Christopher Mahony, Jennifer L Marshall, Charlotte G Smith, Peter Monksfield, Richard I Irving, Ingrid E Dumitriu, Christopher D Buckley, Adam P Croft
BACKGROUND: Vestibular schwannomas (VSs) remain a challenge due to their anatomical location and propensity to growth. Macrophages are present in VS but their roles in VS pathogenesis remains unknown. OBJECTIVES: The objective was to assess phenotypic and functional profile of macrophages in VS with single-cell RNA sequencing (scRNAseq). METHODS: scRNAseq was carried out in three VS samples to examine characteristics of macrophages in the tumour...
March 13, 2024: British Journal of Cancer
https://read.qxmd.com/read/38478342/mimicking-the-tumor-niche-methods-for-isolation-culture-and-characterization-of-cancer-stem-cells-and-multicellular-spheroids
#29
JOURNAL ARTICLE
Laura De Lara-Peña, Cristiano Farace, Andrea Pisano, Julia López de Andrés, Grazia Fenu, Federica Etzi, Carmen Griñán-Lisón, Juan Antonio Marchal, Roberto Madeddu
Cancer stem cells (CSCs) play a significant role in driving several tumor hallmarks. Their behavior and tumor progression are strictly related to the tumor microenvironment (TME). The dynamic interplay between CSCs and TME drives metastasis, chemoresistance, and disease relapse. In this chapter, we describe different techniques and protocols for isolating, culturing, and characterizing CSCs and we explain the methodology for the culture of multicellular spheroids comprising CSCs.
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38477040/hypoalbuminemia-but-not-derived-neutrophil-to-lymphocyte-ratio-dnlr-predicts-overall-survival-in-neuroendocrine-tumours-undergoing-peptide-receptor-radionuclide-therapy-a-retrospective-cohort-study-of-557-patients
#30
JOURNAL ARTICLE
Dimitrios Papantoniou, Katarzyna Fröss-Baron, Ulrike Garske-Román, Anders Sundin, Espen Thiis-Evensen, Malin Grönberg, Staffan Welin, Eva Tiensuu Janson
Several inflammation scores have shown association with survival outcomes for patients with neuroendocrine tumours (NET) treated with peptide receptor radionuclide therapy (PRRT). However, whether these scores add value to established prognostic factors remains unknown. In this retrospective, cohort study of 557 NET patients undergoing PRRT in a tertiary referral centre from 2005 to 2015, we examined inflammatory markers and scores previously associated with cancer outcomes, using Cox proportional hazard models and Akaike's information criterion...
March 13, 2024: Journal of Neuroendocrinology
https://read.qxmd.com/read/38476302/embryonal-sarcoma-of-the-liver-in-the-adult-challenges-in-the-diagnosis-of-a-rare-entity
#31
JOURNAL ARTICLE
Guilherme Nogueira Fontinha, João Martins Gama, Rui Caetano Oliveira, Augusta Cipriano
INTRODUCTION: Embryonal sarcoma of the liver (ESL) is a rare neoplasm of the liver occurring mainly in paediatric ages. Making the correct diagnosis can be challenging as the laboratory and radiological findings that are often nonspecific, and the tumour immunophenotype is poorly defined and even somewhat variable. CASE PRESENTATION: A large epigastric mass was detected in a computerized tomography scan of a 43-year-old woman presenting with abdominal pain and bloating...
February 2024: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38474372/exploring-the-interplay-of-runx2-and-cxcr4-in-melanoma-progression
#32
JOURNAL ARTICLE
Luca Dalle Carbonare, Arianna Minoia, Anna Vareschi, Francesca Cristiana Piritore, Sharazed Zouari, Alberto Gandini, Mirko Meneghel, Rossella Elia, Pamela Lorenzi, Franco Antoniazzi, João Pessoa, Donato Zipeto, Maria Grazia Romanelli, Daniele Guardavaccaro, Maria Teresa Valenti
Overexpression of the Runt-related transcription factor 2 ( RUNX2 ) has been reported in several cancer types, and the C-X-C motif chemokine receptor 4 ( CXCR4 ) has an important role in tumour progression. However, the interplay between CXCR4 and RUNX2 in melanoma cells remains poorly understood. In the present study, we used melanoma cells and a RUNX2 knockout ( RUNX2 -KO) in vitro model to assess the influence of RUNX2 on CXCR4 protein levels along with its effects on markers associated with cell invasion and autophagy...
February 27, 2024: Cells
https://read.qxmd.com/read/38474072/lumican-a-multifunctional-cell-instructive-biomarker-proteoglycan-has-novel-roles-as-a-marker-of-the-hypercoagulative-state-of-long-covid-disease
#33
REVIEW
Margaret M Smith, James Melrose
This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby regulating cell proliferation, differentiation, inflammation and the innate and humoral immune systems to combat infection. The exponential increase in publications in the last decade dealing with lumican testify to its role as a pleiotropic biomarker regulatory protein...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474001/synergy-between-pedf-and-doxorubicin-in-breast-cancer-cells-effects-on-metastatic-and-metabolic-pathways
#34
JOURNAL ARTICLE
Raziyeh Abooshahab, Hani Al-Salami, Crispin R Dass
Pigment epithelium-derived factor (PEDF), a serine protease inhibitor (Serpin) family member, shows promise in inhibiting tumour growth. In our study, we explored the effects of PEDF on the efficacy of the frontline chemotherapy agent doxorubicin (Dox) in BC cells. We found that Dox+PEDF treatment significantly reduced glucose uptake in MDA-MB-231 cells compared to the control ( p = 0.0005), PEDF ( p = 0.0137), and Dox ( p = 0.0171) alone but paradoxically increased it in MCF-7 cells. Our findings further revealed that PEDF, Dox, and Dox+PEDF substantially hindered tumour cell migration from tumour spheroids, with Dox+PEDF showing the most significant impact ( p < 0...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473874/clinical-relevance-of-tumour-infiltrating-immune-cells-in-her2-negative-breast-cancer-treated-with-neoadjuvant-therapy
#35
JOURNAL ARTICLE
Cristina Arqueros, Alberto Gallardo, Silvia Vidal, Rubén Osuna-Gómez, Ariadna Tibau, Olga Lidia Bell, Teresa Ramón Y Cajal, Enrique Lerma, Bárbara Lobato-Delgado, Juliana Salazar, Agustí Barnadas
Currently, therapy response cannot be accurately predicted in HER2-negative breast cancer (BC). Measuring stromal tumour-infiltrating lymphocytes (sTILs) and mediators of the tumour microenvironment and characterizing tumour-infiltrating immune cells (TIICs) may improve treatment response in the neoadjuvant setting. Tumour tissue and peripheral blood samples were retrospectively collected from 118 patients, and sTILs were evaluated. Circulating exosomes and myeloid-derived suppressor cells were determined by flow cytometry...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473425/ca9-cyfip2-and-lgals3bp-a-novel-biomarker-panel-to-aid-prognostication-in-glioma
#36
JOURNAL ARTICLE
Amanda L Hudson, Angela Cho, Emily K Colvin, Sarah A Hayes, Helen R Wheeler, Viive M Howell
Brain cancer is a devastating and life-changing disease. Biomarkers are becoming increasingly important in addressing clinical issues, including in monitoring tumour progression and assessing survival and treatment response. The goal of this study was to identify prognostic biomarkers associated with glioma progression. Discovery proteomic analysis was performed on a small cohort of astrocytomas that were diagnosed as low-grade and recurred at a higher grade. Six proteins were chosen to be validated further in a larger cohort...
March 6, 2024: Cancers
https://read.qxmd.com/read/38473424/a-preliminary-evaluation-of-advanced-oxidation-protein-products-aopps-as-a-potential-approach-to-evaluating-prognosis-in-early-stage-breast-cancer-patients-and-its-implication-in-tumour-angiogenesis-a-7-year-single-centre-study
#37
JOURNAL ARTICLE
Marta Napiórkowska-Mastalerz, Tomasz Wybranowski, Maciej Bosek, Stefan Kruszewski, Piotr Rhone, Barbara Ruszkowska-Ciastek
Breast cancer (BrC) is a highly prevalent tumour among women. The high incidence and mortality rate of BrC prompts researchers to search for new markers that will provide information on the possible impact of the therapy on the risk of cancer-related events. This study aimed to investigate whether the level of advanced oxidation protein products (AOPPs) may have a potential impact on disease-free (DFS) and overall survival (OS) in BrC patients with early-stage cancer. Additionally, we tried to assess the relationship between AOPPs and angiogenic parameters...
March 6, 2024: Cancers
https://read.qxmd.com/read/38473282/liver-transplantation-for-hepatocellular-carcinoma-beyond-the-milan-criteria-a-specific-role-for-living-donor-liver-transplantation-after-neoadjuvant-therapy
#38
JOURNAL ARTICLE
Oliver Rohland, Lea Freye, Laura Schwenk, Aladdin Ali-Deeb, Michael Ardelt, Astrid Bauschke, Utz Settmacher, Falk Rauchfuß, Felix Dondorf
PURPOSE: This study was designed to elucidate the various new classifications and the use of LDLT and bridging therapy for HCC in this context beyond the Milan criteria (MC). METHODS: The clinical data of patients with HCC outside the MC who underwent LT at Jena University between January 2007 and August 2023 were retrospectively analysed. Eligible patients were classified according to various classification systems. Clinicopathological features, overall and disease-free survival rates were compared between LT and LDLT within the context of bridging therapy...
February 25, 2024: Cancers
https://read.qxmd.com/read/38469554/baseline-levels-of-circulating-galectin-1-associated-with-radiographic-hand-but-not-radiographic-knee-osteoarthritis-at-a-two-year-follow-up
#39
JOURNAL ARTICLE
M L E Andersson, M Zimmerman, E Brogren, S Bergman, L Strindberg, E Fryk, P A Jansson
OBJECTIVE: We tested the potential of circulating galectin-1, interleukin (IL)-1 beta, IL-6, and tumour necrosis factor alpha (TNF alpha) levels at baseline in individuals with knee pain as biomarkers for development of radiographic knee and/or hand osteoarthritis (OA). DESIGN: This study comprised 212 individuals with knee pain from the Halland osteoarthritis cohort (HALLOA). Clinical characteristics and serum/plasma levels of galectin-1, IL-1 beta, IL-6, and TNF alpha were measured at baseline, and knee and hand radiographs were obtained at a two-year follow-up...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38469233/a-facs-based-novel-isolation-technique-identifies-heterogeneous-ctcs-in-oral-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Anshika Chauhan, Arnab Pal, Meenakshi Sachdeva, Geeta S Boora, Monil Parsana, Jaimanti Bakshi, Roshan Kumar Verma, Radhika Srinivasan, Debajyoti Chatterjee, Arindam Maitra, Sushmita Ghoshal
PURPOSE: Isolating circulating tumour cells (CTCs) from the blood is challenging due to their low abundance and heterogeneity. Limitations of conventional CTC detection methods highlight the need for improved strategies to detect and isolate CTCs. Currently, the Food and Drug Administration (FDA)-approved CellSearch™ and other RUO techniques are not available in India. Therefore, we wanted to develop a flexible CTC detection/isolation technique that addresses the limitation(s) of currently available techniques and is suitable for various downstream applications...
2024: Frontiers in Oncology
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