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Soojung Lee, Trine V Axelsen, Nicolai Jessen, Stine F Pedersen, Pernille Vahl, Ebbe Boedtkjer
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+ ,HCO3 - -cotransporter NBCn1 (Slc4a7) to intracellular acid-base regulation in ErbB2-induced breast cancer tissue and the consequences of NBCn1 knockout for breast tumor development and growth. We demonstrate an approximately 2-fold increase of NBCn1 protein abundance in ErbB2-induced breast cancer tissue compared to normal breast tissue despite a 4-fold decrease in the NBCn1 mRNA level...
June 15, 2018: Oncogene
Jikui Guan, Susanne Fransson, Joachim Tetteh T Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Petter Svenberg, Kristina Ruuth, Sandra Wessman, Alia Shamikh, Hans Jacobsson, Lena Gordon, Jakob Stenman, Erik Larsson, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H Palmer, Bengt Hallberg
Tumors with Anaplastic Lymphoma Kinase (ALK) fusion rearrangements, including non-small cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. While mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, due to lack of therapeutic options...
June 15, 2018: Cold Spring Harbor Molecular Case Studies
Orkun Yılmaz, Ahmet Özmeriç, Kadir Bahadır Alemdaroğlu, Pınar Celepli, Sema Hücümenoğlu, Özgür Şahin
AIMS: The aim of the study was to test if the addition of CGF to the Masquelet technique contributes to the quality of the membrane formed surrounding the polymethylmethacrylate (PMMA), in terms of inflammation, proliferation and vasculazition in the Masquelet technique in the early and late phases in a rabbit model. MATERIALS AND METHODS: A critical bone defect of 15 mm was created in radius diaphysis, leaving 3 cm of intact bone to the joint. To mimic the Masquelet technique and to increase stability, a 6-hole 1...
June 8, 2018: Injury
Swathi Balaji, Makhdum Ahmed, Elizabeth Lorence, Fangfang Yan, Krystle Nomie, Michael Wang
Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becoming increasingly treatable. The majority of patients, especially if young, achieve a progression-free survival of at least 5 years. Mantle cell lymphoma can initially be treated with an anti-CD20 antibody in combination with a chemotherapy backbone, such as VR-CAP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, and prednisone) or R-CHOP (the anti-CD20 monoclonal antibody rituximab administered with cyclophosphamide, doxorubicin, vincristine, and prednisone)...
June 15, 2018: Journal of Hematology & Oncology
Nobuaki Sato, Norikazu Masuda, Takashi Morimoto, Takayuki Ueno, Chizuko Kanbayashi, Koji Kaneko, Hiroyuki Yasojima, Shigehira Saji, Hironobu Sasano, Satoshi Morita, Shinji Ohno, Masakazu Toi
Patients with estrogen receptor (ER)-positive breast cancer are less likely to achieve a pathological complete response (pCR) with neoadjuvant chemotherapy. Neoadjuvant endocrine therapy may be more appropriate than neoadjuvant chemotherapy in these hormone-sensitive patients. Most patients with ER-positive breast cancer are postmenopausal, and therefore, generally older and less able to tolerate chemotherapy. We aimed to investigate the efficacy and safety of tailored neoadjuvant endocrine and chemoendocrine therapy for postmenopausal breast cancer patients...
June 14, 2018: Cancer Medicine
Joseph J Fantony, Lauren E Howard, Ilona Csizmadi, Andrew J Armstrong, Amy L Lark, Colette Galet, William J Aronson, Stephen J Freedland
AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Durham and West LA Veterans Affairs Hospitals. Hazard ratios (HR) for Ki67 expression and time to BCR were estimated using Cox regression. RESULTS: Ki67 was associated with more recent surgery year (p < 0...
June 15, 2018: Biomarkers in Medicine
Zi-Wen Long, Jiang-Hong Wu, Cai- Hong, Ya-Nong Wang, Ye Zhou
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR- 374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1...
June 14, 2018: Molecules and Cells
Pengfeng Gong, Qianfeng Zhuang, Kun Wang, Renfang Xu, Yiming Chen, Xiaogang Wang, Shuai Yin
RATIONALE: Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions is a rare subtype of renal cell carcinoma. This predominantly occurs in juveniles, but rarely seen in adults with lymph node or organic metastasis and a worsened prognosis. PATIENTS CONCERNS: Herein, we presented 3 adult cases of Xp11-RCC. Two patients were in early stage and good condition, and the third patient had lymph node metastasis but showed no recurrence after a 3-month follow-up...
June 2018: Medicine (Baltimore)
Jia-Wei Li, Kai Zhang, Zhao-Ting Shi, Xun Zhang, Juan Xie, Jun-Ying Liu, Cai Chang
In this study, we aimed to evaluate the clinical and pathological factors that associated with sonographic appearances of triple-negative (TN) invasive breast carcinoma. With the ethical approval, 560 patients who were pathologically confirmed as invasive breast carcinoma were reviewed for ultrasound, clinical, and pathological data. Logistic regression analysis was used to identify the typical sonographic features for TN invasive breast carcinomas. The effect of clinical and pathological factors on the sonographic features of TN invasive breast carcinoma was studied...
June 13, 2018: Scientific Reports
Alessandro Vanoli, Stefano La Rosa, Emanuela Miceli, Catherine Klersy, Roberta Maragliano, Francesca Capuano, Andrea Persichella, Michele Martino, Frediano Inzani, Ombretta Luinetti, Antonio Di Sabatino, Fausto Sessa, Marco Paulli, Gino Roberto Corazza, Guido Rindi, Cesare Bordi, Carlo Capella, Enrico Solcia
BACKGROUND: Gastric neuroendocrine neoplasms (NENs) are very heterogeneous, ranging from mostly indolent, atrophic gastritis-associated, type I neuroendocrine tumors (NETs), through highly malignant, poorly differentiated neuroendocrine carcinomas (pdNECs), to sporadic type III NETs with intermediate prognosis, and various rare tumor types. Histologic differentiation, proliferative grade, size, level of gastric wall invasion, and local or distant metastases are used as prognostic markers...
June 12, 2018: Neuroendocrinology
M Arnedos, M A Bayar, B Cheaib, V Scott, I Bouakka, A Valent, J Adam, V Leroux-Kozal, V Marty, A Rapinat, C Mazouni, B Sarfati, I Bieche, C Balleyguier, D Gentien, S Delaloge, M Lacroix-Triki, S Michiels, F Andre
Background: The CDK4/6 inhibitor Palbociclib is a new standard treatment in hormone-receptor positive breast cancer patients. No predictive biomarkers have been identified and no pharmacodynamics has properly been described so far. Patients and methods: Patients with early breast cancer were randomized 3:1 to oral palbociclib 125mg daily for 14 days until the day before the surgery vs. no treatment. Primary objective was antiproliferative response defined as a natural logarithm of Ki67 expression at day 15 below 1...
June 11, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Colin J R Stewart, Maxine L Crook
Ovarian teratomas potentially demonstrate a wide range of tissue elements including central nervous system differentiation. The latter can include cerebellar tissue, which in our experience remains an under-recognized phenomenon. In the current study we present a review of 6 ovarian teratomas including 4 mature cystic teratomas and 2 immature teratomas showing cerebellar differentiation. Two cases were seen in consultation because the cerebellar elements were initially misinterpreted as immature teratomas. Two mature cystic teratomas focally demonstrated a distinct cerebellar architecture including folial type structures, but in all cases the cerebellar elements usually showed a less organized anatomic appearance, and sometimes these were concerning for immature teratomas upon initial examination...
July 2018: International Journal of Gynecological Pathology
Nikolaus Luft, Ricarda G Schumann, Martin Dirisamer, Daniel Kook, Jakob Siedlecki, Christian Wertheimer, Siegfried G Priglinger, Wolfgang J Mayer
PURPOSE: To assess the wound healing, inflammation, and tissue ultrastructure in the human corneal stroma after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (FS-LASIK). METHODS: Sixteen corneoscleral discs of 16 human donors unsuitable for corneal transplantation were obtained from an eye bank. Eight eyes underwent SMILE with -5.00 diopters (D) of myopic correction; in 3 of them the lenticule was not extracted. Further 5 donor corneas were subjected to FS-LASIK with -5...
June 1, 2018: Journal of Refractive Surgery
Jeremy D Hill, Viviana Zuluaga-Ramirez, Sachin Gajghate, Malika Winfield, Yuri Persidsky
BACKGROUND AND PURPOSE: The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid-like compounds seen can be attributed to the cannabinoid 1 receptor (CB1 R) or cannabinoid 2 receptor (CB2 R). The recently de-orphaned GPR55 has been shown to be activated by numerous cannabinoid ligands suggesting that GPR55 is a third cannabinoid receptor. Here we examined the role of GPR55 activation in NSC proliferation and early adult neurogenesis...
June 11, 2018: British Journal of Pharmacology
Anne Andert, Hamid P Alizai, Tom Florian Ulmer, Christoph Heidenhain, Patrick Ziegler, Tim H Brümmendorf, Ulf Peter Neumann, Fabian Beier, Christian D Klink
BACKGROUND: The aim of this study was to investigate telomere length in hepatocytes as a biomarker for liver regeneration after partial hepatectomy (PH) in rats. MATERIALS AND METHODS: Sixty male Wistar rats underwent a 70% PH. One-month-old rats were assigned to group Y (n = 30) and 4-month-old rats were assigned to group O (n = 30). The rats were euthanized, and their livers were then harvested at postoperative day (POD) 1, 2, 3, 4, or 7. Telomere lengths and established parameters for liver regeneration (residual liver weight and levels of proliferating cell nuclear antigen [PCNA], Ki67, and interleukin [IL]-6) were measured...
June 8, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
L Held, A Ruetten, H Kutzner, G Palmedo, B John, T Mentzel
BACKGROUND: Endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare low-grade primary cutaneous sweat gland carcinoma with predilection for the periorbital skin in elderly female patients. METHODS: We describe eleven cases of EMPSGC using a broad panel of immunohistochemical markers including BerEP4, cytokeratin 7, CAM 5.2; synaptophysin, chromogranin, cytokeratin 20, Ki67, progesterone receptor, and estrogen receptor. Calponin (1A4) and p63 were used to detect surrounding myoepithelial cells...
June 7, 2018: Journal of Cutaneous Pathology
Kwame Doh, Ibou Thiam, Romulus Carmen Adechina Takin, Khaled Sonhaye, Gisèle Woto-Gaye
INTRODUCTION: Sebaceous lymphadenoma of the parotid (SLP) is a rare, benign tumor with similar epidemiological and macroscopic characteristics with other sebaceous differentiated tumors of the parotid (SDTP). The authors report a case of SLP in an 80-year-old woman. They then recall the distinctive histological and immunohistochemical criteria of SDTP. OBSERVATION: Mrs P. D. was received during a surgical consultation for the management of a painless right parotid swelling that has evolved for 10years, increasing slightly in volume...
June 4, 2018: Annales de Pathologie
Lichuan Zhang, Chunhua Hu, Xiaodan Zheng, Dawei Wu, Haili Sun, Wei Yu, Ying Wu, Dong Chen, Qianwen Lv, Ping Zhang, Xiping Li, Honggang Liu, Yongxiang Wei
RATIONALE: Oncocytic Schneiderian papillomas (OSP) are an uncommon type of sinonasal papillomas that arise from the Schneiderian epithelium, accounting for only 6% of all sinonasal papillomas. Malignancies arising in OSP are rare and are almost always described as in situ or invasive squamous cell carcinoma, although mucoepidermoid, small cell carcinoma and sinonasal undifferentiated carcinoma have also been reported. To our knowledge, only 18 such instances have been reported in the medical literature...
June 2018: Medicine (Baltimore)
Hongyi Cao, Biying Jiang, Yang Zhao, Chuifeng Fan
RATIONALE: Anaplastic meningioma, a rare subtype of meningioma, has malignant morphological characteristics and a World Health Organization (WHO) grade of III. PATIENT CONCERNS: In this report, we present findings from 6 cases of anaplastic meningioma. DIAGNOSES: Pathological examination of the tumors, including hematoxylin and eosin staining and immunohistochemical staining, was performed. Of the six cases of anaplastic meningioma, two were recurrent tumors from original seminoma with a WHO grade of I...
June 2018: Medicine (Baltimore)
Kirsi Santti, Hanna Ihalainen, Mikko Rönty, Tom Böhling, Christina Karlsson, Caj Haglund, Maija Tarkkanen, Carl Blomqvist
BACKGROUND AND OBJECTIVES: Desmoid tumors are soft-tissue tumors originating from myofibroblasts with a tendency to recur after surgery. High expression of proliferation markers is associated with shortened progression-free and/or overall survival in many neoplasms, including soft-tissue sarcomas. We investigated the prognostic role of cyclin A and Ki67 in desmoid tumors by immunohistochemistry. METHODS: The study included 76 patients with desmoid tumor operated at Helsinki University Hospital between 1987 and 2011...
June 7, 2018: Journal of Surgical Oncology
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