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Neuroendocrine tumour

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https://www.readbyqxmd.com/read/29785514/correlation-of-dose-with-toxicity-and-tumour-response-to-90-y-and-177-lu-prrt-provides-the-basis-for-optimization-through-individualized-treatment-planning
#1
REVIEW
Marta Cremonesi, Mahila Esmeralda Ferrari, Lisa Bodei, Carlo Chiesa, Anna Sarnelli, Cristina Garibaldi, Massimiliano Pacilio, Lidia Strigari, Paul Eugene Summers, Roberto Orecchia, Chiara Maria Grana, Francesca Botta
PURPOSE: Peptide receptor radionuclide therapy (PRRT) with 90 Y-labelled and 177 Lu-labelled peptides is an effective strategy for the treatment of metastatic/nonresectable neuroendocrine tumours (NETs). Dosimetry provides important information useful for optimizing PRRT with individualized regimens to reduce toxicity and increase tumour responses. However, this strategy is not applied in routine clinical practice, despite the fact that several dosimetric studies have demonstrated significant dose-effect correlations for normal organ toxicity and tumour response that can better guide therapy planning...
May 21, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29781575/brn2-a-pouerful-driver-of-melanoma-phenotype-switching-and-metastasis
#2
REVIEW
Mitchell E Fane, Yash Chhabra, Aaron G Smith, Richard A Sturm
The POU domain family of transcription factors play a central role in embryogenesis and are highly expressed in neural crest cells and the developing brain. BRN2 is a class III POU domain protein that is a key mediator of neuroendocrine and melanocytic development and differentiation. While BRN2 is a central regulator in numerous developmental programs, it has also emerged as a major player in the biology of tumourigenesis. In melanoma, BRN2 has been implicated as one of the master regulators of the acquisition of invasive behavior within the phenotype-switching model of progression...
May 21, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29778998/coexisting-squamous-cell-carcinoma-and-high-grade-neuroendocrine-carcinoma-small-cell-type-a-rare-collision-in-cervix
#3
Seema Kaushal, Sandeep R Mathur, Sunesh Kumar
Collision tumours of the uterine cervix are extremely uncommon with exact incidence not known. Unlike squamous cell carcinoma (SCC) and adenocarcinoma that are known to coexist, small cell neuroendocrine carcinoma (SCNEC) is rarely documented with other histological types in the cervix. We report such rare case of a collision tumour in cervix displaying dual histological component of SCNEC and SCC in a 36-year-old woman. The case is being presented because of its rarity and represents a unique and hitherto seldom-reported combination of two malignant tumours with distinct and often contrasting epidemiology, histology and prognosis coexisting in the same patient...
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29769293/emerging-multitarget-tyrosine-kinase-inhibitors-in-the-treatment-of-neuroendocrine-neoplasms
#4
Federica Grillo, Tullio Florio, Francesco Ferraù, Elda Kara, Giuseppe Fanciulli, Antongiulio Faggiano, Annamaria A L Colao
In the last few years, the therapeutic approach for neuroendocrine neoplasms (NENs) has changed dramatically following the approval of several novel targeted treatments. The multi-target tyrosine kinase inhibitor (MTKI), sunitinib malate, has been approved by regulatory agencies in pancreatic NENs. The MTKI class, however, includes several other molecules (approved for other conditions), which are currently being studied in NENs. An in depth review on the studies published on the following MTKIs in neuroendocrine tumours: axitinib, cabozantinib, famitinib, lenvatinib, nintedanib, pazopanib, sorafenib and sulfatinib was performed...
May 16, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29757368/the-long-noncoding-rna-landscape-of-neuroendocrine-prostate-cancer-and-its-clinical-implications
#5
Varune Rohan Ramnarine, Mohammed Alshalalfa, Fan Mo, Noushin Nabavi, Nicholas Erho, Mandeep Takhar, Robert Shukin, Sonal Brahmbhatt, Alexander Gawronski, Maxim Kobelev, Mannan Nouri, Dong Lin, Harrison Tsai, Tamara L Lotan, R Jefferey Karnes, Mark A Rubin, Amina Zoubeidi, Martin E Gleave, Cenk Sahinalp, Alexander W Wyatt, Stanislav V Volik, Himisha Beltran, Elai Davicioni, Yuzhuo Wang, Colin C Collins
Background: Treatment induced neuroendocrine prostate cancer (tNEPC) is an aggressive variant of late-stage metastatic castrate resistant (mCRPC) prostate cancer that commonly arises through neuroendocrine transdifferentiation (NEtD). Treatment options are limited, ineffective, and for most patients, results in death in less than a year. We previously developed a first-in-field patient-derived xenograft (PDX) model of NEtD. Longitudinal deep transcriptome profiling of this model enabled monitoring of dynamic transcriptional changes during NEtD and in the context of androgen deprivation...
May 10, 2018: GigaScience
https://www.readbyqxmd.com/read/29755775/rectal-and-anal-canal-neuroendocrine-tumours
#6
Teresa Raposo André, Margarida Brito, João Geraldes Freire, António Moreira
Neuroendocrine tumors (NETs) are rare, representing 0.5% of all newly diagnosed malignancies. Rectal and anal canal (AC) NETs account for less than 1% of all rectal and AC cancers. Review our institutional experience on NET of the rectum and AC, with emphasis on demographic, histological and treatment features and oncologic outcomes. The study group was identified from the Portuguese Regional South Oncological Registry. From 2000 to 2014, 22 patients with rectal or AC NETs were treated at our institution. Medical records were retrospectively reviewed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752349/paediatric-pancreatic-neuroendocrine-tumours-in-von-hippel-lindau-disease
#7
Samuel Matthew O'Toole, Anju Sahdev, Satya Bhattacharya, Roger Feakins, Evelien F Gevers, William Drake
Extract: Pancreatic neuroendocrine tumours (pNETs) are an established feature of von Hippel-Lindau disease (VHL), occurring in up to 17% of mutation carriers (Libutti et al. 2000; Blansfield et al. 2007; Erlic et al. 2010; Igarashi et al. 2014). The natural history of VHL-pNETs is poorly characterised with metastatic disease occurring in up to 25% of affected individuals (Erlic et al. 2010). Management of this unique pNET subgroup is complicated by the potential for multifocal and metachronous disease as well as extra-pancreatic VHL-related neoplasms (e...
May 11, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29746922/diabetes-and-pancreatic-neuroendocrine-tumours-which-interplays-if-any
#8
REVIEW
Marco Gallo, Rosaria Maddalena Ruggeri, Giovanna Muscogiuri, Genoveffa Pizza, Antongiulio Faggiano, Annamaria Colao
Pancreatic neuroendocrine tumours (PanNETs) represent an uncommon type of pancreatic neoplasm, whose incidence is increasing worldwide. As per exocrine pancreatic cancer, a relationship seems to exist between PanNETs and glycaemic alterations. Diabetes mellitus (DM) or impaired glucose tolerance often occurs in PanNET patients as a consequence of hormonal hypersecretion by the tumour, specifically affecting glucose metabolism, or due to tumour mass effects. On the other hand, pre-existing DM may represent a risk factor for developing PanNETs and is likely to worsen the prognosis of such patients...
May 2, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29745005/systematic-review-and-meta-analysis-of-appendiceal-carcinoid-tumors-in-children
#9
Ike Njere, Lisa Linnéa Smith, Dushanthi Thurairasa, Rubina Malik, Iona Jeffrey, Bruce Okoye, Chandrasen Sinha
OBJECTIVE: The study's aim was to review the literature regarding past and current practices in managing incidental appendiceal carcinoid tumors and need for more procedures. METHOD: A search of MEDLINE, Embase, CINAHL, and Cochrane databases of systematic reviews was undertaken of the English language literature. The mesh terms used were "carcinoid" or "neuroendocrine," "tumour" or "tumor," "appendix," "appendicectomy," or "appendectomy," and "child," "pediatric," or "paediatric...
May 10, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29744252/paediatric-vipoma-a-jamboree-of-electrolytes
#10
Amit Rastogi, Vansh Priya, Rudrashish Haldar, Rameez Riaz
Vasoactive intestinal peptide secreting tumour (VIPoma) is a rare type of neuroendocrine tumour (NET), primarily located in the tail of pancreas. This type of tumour presents with myriad of metabolic and electrolyte misbalances in the preoperative period, mainly due to increased vasoactive intestinal peptide (VIP) levels. Perioperative management of patients with VIPoma is challenging, especially when dealing with paediatric patients. The anaesthetic management of a two-year-old girl who was selected for VIPoma resection is hereby presented...
April 2018: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29741203/peptide-receptor-radionuclide-therapy-for-advanced-gastroenteropancreatic-neuroendocrine-tumors-from-oncology-perspective
#11
Agnieszka Kolasińska-Ćwikła, Anna Łowczak, Katarzyna Maciejkiewicz Maciejkiewicz, Jarosław Bogdan Ćwikła
Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e.g. arising from the small bowel (often called carcinoid tumours), the pancreas, duodenum or stomach, but also from the large bowel or the lung and many other tissues (so called diffuse neuroendocrine system)...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29739708/usefulness-of-combined-imaging-with-68-ga-dotatoc-pet-ct-and-spleen-scintigraphy-in-differentiating-a-neuroendocrine-tumour-of-the-pancreatic-tail-from-splenic-lesions-in-a-patient-with-posttraumatic-splenosis
#12
J Maffey-Steffan, C Uprimny, R Moncayo, A S Kroiss, I J Virgolini
No abstract text is available yet for this article.
May 5, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29731938/treatment-of-a-patient-with-merkel-cell-skin-carcinoma-using-radiation-therapy-a-case-report
#13
Andrej Petrov, Slavica Kraleva, Katerina Kubelka-Sabit, Deva Petrova
BACKGROUND: Merkel cell carcinoma (MCC) is a rare, very aggressive tumour. The pathogenesis remains unclear, but UV radiation, immunosuppression, and the presence of Merkel cell polyomavirus in the tumour genome appear to have a key role. Merkel cell carcinoma is a highly aggressive tumour that often has a lethal end. CAS REPORT: A patient at 93 years of age comes for an examination by a dermatologist due to a rapidly growing nodular tumour growth in the forehead area...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29717346/health-related-quality-of-life-after-surgery-for-small-intestinal-neuroendocrine-tumours
#14
Anna Caterina Milanetto, Erik Nordenström, Anna Sundlöv, Martin Almquist
BACKGROUND: Overall survival for patients with small intestinal neuroendocrine tumours (siNETs) is long, even with metastatic disease, making quality of life issues relevant. The impact of surgery on quality of life is not known. We investigated determinants of health-related quality of life in patients who had undergone surgery for a siNET. METHODS: Patients operated for a siNET between 1998 and 2016 at Skåne University Hospital (Lund, Sweden), who were alive in February 2017, were sent two questionnaires constructed by the European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30, EORTC QLQ-GINET21)...
May 1, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29704389/recommended-parameters-for-pathology-reporting-of-gastroenteropancreatic-neuroendocrine-tumours-gep-nets
#15
(no author information available yet)
No abstract available.
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29700099/effect-of-a549-neuroendocrine-differentiation-on-cytotoxic-immune-response
#16
Irasema Mendieta, Rosa-Elvira Nunez-Anita, Gilberto Pérez-Sánchez, Lenin Pavon, Alfredo Rodríguez-Cruz, Guadalupe Garcia-Alcocer, Laura Cristina Berumen
The present study was designed to determine the effects of factors secreted by the lung adenocarcinoma cell line with the neuroendocrine phenotype, A549NED, on cytotoxic T lymphocytes (CTL) activity in vitro. A perspective that integrates the nervous, endocrine and immune system in cancer research is essential to understand the complexity of dynamic interactions in tumours. Extensive clinical research suggests that neuroendocrine differentiation (NED) is correlated with worse patient outcomes; however, little is known regarding the effects of neuroendocrine factors on the communication between the immune system and neoplastic cells...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29685756/treatment-challenges-in-and-outside-a-network-setting-gastrointestinal-neuroendocrine-tumours
#17
REVIEW
Faidon-Marios Laskaratos, Martyn Caplin
Gastroenteropancreatic neuroendocrine tumours (GEP NETs) are relatively rare neoplasms arising from the enterochromaffin cells of the gastrointestinal tract. They comprise a heterogeneous group of tumours with a diverse natural history, variable biological behaviour and different clinical outcomes. Their management is often complex and may include a combination of surgery, systemic treatments and locoregional approaches. A multidisciplinary team approach is therefore essential for the optimal care of patients with GEP NETs...
March 22, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29675259/successful-neoadjuvant-peptide-receptor-radionuclide-therapy-for-an-inoperable-pancreatic-neuroendocrine-tumour
#18
Tiago Nunes da Silva, M L F van Velthuysen, Casper H J van Eijck, Jaap J Teunissen, J Hofland, Wouter W de Herder
Non-functional pancreatic neuroendocrine tumours (NETs) can present with advanced local or distant (metastatic) disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT) using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29667585/recent-developments-in-the-diagnosis-and-therapy-of-well-differentiated-neuroendocrine-tumours
#19
J Hofland, R A Feelders, T Brabander, G J H Franssen, W W de Herder
Well-differentiated neuroendocrine tumours (NETs) of the digestive tract are being increasingly detected, which is partly explained by the increased use of endoscopic and cross-sectional imaging as well as improved recognition at histopathological evaluation. After the discovery of this relatively indolent type of epithelial malignancy over 100 years ago, their sporadic occurrence and divergent biological behaviour at multiple primary sites have hampered dedicated studies into NET pathogenesis and testing of drug efficacy in well-designed clinical trials...
April 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29666690/small-cell-neuroendocrine-carcinoma-of-the-cervix-masquerading-as-a-cervical-fibroid-report-of-a-rare-entity
#20
Mukta Pujani, Kanika Singh, Varsha Chauhan, Raina Chawla, Rashmi Ahuja
Primary neuroendocrine tumours of the cervix are extremely rare, with an incidence of only 0.5-1%; as such, these entities can present a clinical and diagnostic challenge. Small-cell neuroendocrine carcinomas of the cervix are highly aggressive tumours that have a tendency to metastasise. We report a 44-year-old woman who presented to the Gynaecology Clinic of the Employees State Insurance Corporation Medical College & Hospital, Faridabad, India, in 2016 with menorrhagia . Based on a clinical examination, she was provisionally diagnosed with a cervical fibroid...
February 2018: Sultan Qaboos University Medical Journal
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