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JOURNAL ARTICLE
Marie Serrie, Fabienne Ribeyre, Laurent Brun, Jean-Marc Audergon, Bénédicte Quilot, Morgane Roth
In a context of urgent need for a more sustainable fruit tree production, it's high time to find durable alternatives to the systematic use of phytosanitary products in orchards. To this aim, resilience can deliver a number of benefits. Relying on a combination of tolerance, resistance and recovery traits, disease resilience appears as a corner stone to cope with the multiple pest and disease challenge over the orchard's lifetime. Here, we propose to describe resilience as the capacity of a tree to be minimally affected by external disturbances or to rapidly bounce back to normal functioning after being exposed to these disturbances...
April 18, 2024: Journal of Experimental Botany
#22
JOURNAL ARTICLE
Claire André, Marie-Ève Martineau-Dussault, Andrée-Ann Baril, Nicola Andrea Marchi, Véronique Daneault, Dominique Lorrain, Carol Hudon, Célyne H Bastien, Dominique Petit, Cynthia Thompson, Judes Poirier, Jacques Montplaisir, Nadia Gosselin, Julie Carrier
STUDY OBJECTIVES: Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status and obstructive sleep apnea...
April 18, 2024: Sleep
#23
JOURNAL ARTICLE
Joanne E Simpson, Noor Gammoh
Macroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been shown to be involved in various aspects of tumor development by engaging with multiple cellular substrates. We recently uncovered a novel role for autophagy in regulating the signaling and levels of PDGFRA, a receptor tyrosine kinase amplified in several cancers. We discovered that PDGFRA can be targeted to autophagic degradation by binding the autophagy cargo receptor SQSTM1...
April 18, 2024: Autophagy
#24
JOURNAL ARTICLE
Heon-Seok Park, Eun Young Lee, Young-Hye You, Marie Rhee, Jong-Min Kim, Seong-Soo Hwang, Poong-Yeon Lee
AIMS/INTRODUCTION: To investigate the long-term efficacy of various encapsulated xenogeneic islet transplantation, and to explore the impact of different donor porcine genetic traits on islet transplantation outcomes. MATERIALS AND METHODS: Donor porcine islets were obtained from wild-type, α1,3-galactosyltransferase knockout (GTKO) and GTKO with overexpression of membrane cofactor protein genotype. Naked, alginate, alginate-chitosan (AC), alginate-perfluorodecalin (A-PFD) and AC-perfluorodecalin (AC-PFD) encapsulated porcine islets were transplanted into diabetic mice...
April 18, 2024: Journal of Diabetes Investigation
#25
JOURNAL ARTICLE
Hanna Puolakka, Anssi Solismaa, Leo-Pekka Lyytikäinen, Merja Viikki, Niko Seppälä, Nina Mononen, Terho Lehtimäki, Olli Kampman
OBJECTIVE: Sialorrhea is a common and uncomfortable adverse effect of clozapine, and its severity varies between patients. The aim of the study was to select broadly genes related to the regulation of salivation and study associations between sialorrhea and dry mouth and polymorphisms in the selected genes. METHODS: The study population consists of 237 clozapine-treated patients, of which 172 were genotyped. Associations between sialorrhea and dry mouth with age, sex, BMI, smoking, clozapine dose, clozapine and norclozapine serum levels, and other comedication were studied...
April 18, 2024: Acta Neuropsychiatrica
#26
JOURNAL ARTICLE
Mohamed Ali Ouadhene, Kenneth A Callicott, Alejandro Ortega-Beltran, Hillary L Mehl, Peter J Cotty, Paola Battilani
Aspergillus flavus is the most frequently identified producer of aflatoxins. Non-aflatoxigenic members of the A. flavus L strains are used in various continents as active ingredients of bioprotectants directed at preventing aflatoxin contamination by competitive displacement of aflatoxin producers. The current research examined the genetic diversity of A. flavus L strain across southern Europe to gain insights into the population structure and evolution of this species and to evaluate the prevalence of genotypes closely related to MUCL54911, the active ingredient of AF-X1...
April 2024: Environmental Microbiology Reports
#27
JOURNAL ARTICLE
Malihe Aghasizadeh, Asieh Ahmadi Hoseini, Reza Sahebi, Tooba Kazemi, Parisa Asadiyan-Sohan, Habibollah Esmaily, Sara Samadi, Amir Avan, Gordon A Ferns, Saeede Khosravi, Hamideh Ghazizadeh, Ebrahim Miri-Moghaddam, Majid Ghayour-Mobarhan
BACKGROUND: Loss-of-function (LOF) variants of the angiopoietin-like 3 (ANGPTL3) gene are reported to be associated with serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) concentrations and thereby affect the risk of cardiovascular disease (CVD). OBJECTIVE: In the present study, we examined the association of rs10789117 in the ANGPTL 3 gene locus and the risk of CVD in the group of people who were part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort...
April 2024: Molecular Genetics & Genomic Medicine
#28
JOURNAL ARTICLE
Xiaofeng Dong, Mengjie Zou, Chunxing Li, Honglin Luo, Shaoliang Zhu, Zheng Gong
Increasing evidence has suggested a strong association of hepatocellular carcinoma (HCC) susceptibility and Gln223Arg (rs1137101) and Lys109Arg (rs1137100) polymorphisms in leptin receptor (LEPR) genes. To provide a quantitative assessment for such correlation, we reviewed all related systems and conducted meta-analysis for case and control researches. A literature search of Web of Science, EMBASE, PubMed, Scopus as well as China National Knowledge Infrastructure databases was collected. 95% confidence intervals (95% CIs) together with odds ratios (ORs) were calculated...
April 18, 2024: Environmental Toxicology
#29
JOURNAL ARTICLE
Glenn Ramsey, Christina M Barriteau
BACKGROUND: For patients with weak or discrepant RhD RBC phenotypes, RHD genotyping is employed to determine need for RhD-negative management. However, many RHD variants are type D-negative or D-positive. Serological recognition rates (RRs) of weak and partial RHD variants are poorly characterized. STUDY DESIGN AND METHODS: Four US studies employing RHD genotyping for weak or discrepant RhD phenotypes provided data for race/ethnicity-specific serological recognition...
April 18, 2024: Transfusion
#30
JOURNAL ARTICLE
Bavisetti Hemasai, Dinesh K Kumbha, Vinodkumar Naik Modem, Srividya K Gannavarapu, Rupeshkumar R Bommaka, Shanthipriya Mallapuram, Sreelakshmi Chintala, Muga D Sreevalli, Eswarayya Ramireddy, Lakshminarayana R Vemireddy
UNLABELLED: The gene-derived functional markers are considered effective to use in marker-assisted breeding and genetic diversity analysis. As of now, no functional markers have been identified from miRNAs regulating yield traits. The miRNAs play a key role as regulators in controlling the candidate genes involved in grain yield improvement in rice. In this study, 13 miRNA-SSR and their target gene SSR markers were mined from 29 yield-responsive miRNA along with their 29 target genes in rice...
April 2024: Molecular Breeding
#31
JOURNAL ARTICLE
Sandhya Kolagatla, Dedeepya Gullapalli, Avinash Vangara, Regina Chan, Derek Jernigan, Nagabhishek Moka, Subramanya Shyam Ganti
Alpha-1 antitrypsin (AAT) deficiency, an autosomal co-dominant inherited condition, significantly impacts lung and liver functions, with mutations in the SERPINA1 gene, notably the Z allele, playing a pivotal role in disease susceptibility. This retrospective descriptive study from a rural Eastern Kentucky pulmonary clinic aimed to characterize patients with AAT deficiency, focusing on demographic, clinical, and laboratory parameters extracted from electronic health records (EHR) of Appalachian Regional Healthcare (ARH)...
March 2024: Curēus
#32
JOURNAL ARTICLE
Naser Sabaghnia, Mostafa Fattahi, Mohsen Janmohammadi, Amin Abbasi
In this study, we examined the effects of seven different sulfur treatments on safflower seeds. The treatments included: no sulfur application (S0), 25 kg/ha of pure bulk sulfur (S25), 50 kg/ha of pure bulk sulfur (S50), 25 kg/ha of sulfur phosphate (Sp25), 50 kg/ha of sulfur phosphate (Sp50), 25 kg/ha of zinc sulfate (Zs25), and 50 kg/ha of zinc sulfate (Zs50). Our evaluation covered various seed quality attributes, including ash percentage (ASH), oil percentage (OIL), and protein percentage (PRO). Additionally, we analyzed the fatty acid composition, including palmitic acid 16 : 0 (PAL), stearic acid 18 : 0 (STE), oleic acid 18 : 1 (OLE), linoleic acid 18 : 2 (LINL), arachidic acid 20 : 0 (ARA), and linolenic acid 18 : 3 (LINN)...
2024: Biotechnologia
#33
Marijne Vandebergh, Eliana Marisa Ramos, Nick Corriveau-Lecavalier, Vijay K Ramanan, John Kornak, Carly Mester, Tyler Kolander, Danielle Brushaber, Adam M Staffaroni, Daniel Geschwind, Amy Wolf, Kejal Kantarci, Tania F Gendron, Leonard Petrucelli, Marleen Van den Broeck, Sarah Wynants, Matthew C Baker, Sergi Borrego-Écija, Brian Appleby, Sami Barmada, Andrea Bozoki, David Clark, R Ryan Darby, Bradford C Dickerson, Kimiko Domoto-Reilly, Julie A Fields, Douglas R Galasko, Nupur Ghoshal, Neill Graff-Radford, Ian M Grant, Lawrence S Honig, Ging-Yuek Robin Hsiung, Edward D Huey, David Irwin, David S Knopman, Justin Y Kwan, Gabriel C Léger, Irene Litvan, Joseph C Masdeu, Mario F Mendez, Chiadi Onyike, Belen Pascual, Peter Pressman, Aaron Ritter, Erik D Roberson, Allison Snyder, Anna Campbell Sullivan, M Carmela Tartaglia, Dylan Wint, Hilary W Heuer, Leah K Forsberg, Adam L Boxer, Howard J Rosen, Bradley F Boeve, Rosa Rademakers
BACKGROUND AND OBJECTIVES: TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly in GRN mutation carriers. Furthermore, TMEM106B has been investigated as a disease modifier in the context of healthy aging and across multiple neurodegenerative diseases. The objective of this study is to evaluate and compare the effect of TMEM106B on gray matter volume and cognition in each of the common genetic FTD groups and in sporadic FTD patients. METHODS: Participants were enrolled through the ARTFL/LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) study, which includes symptomatic and presymptomatic individuals with a pathogenic mutation in C9orf72, GRN, MAPT, VCP, TBK1, TARDBP, symptomatic non-mutation carriers, and non-carrier family controls...
April 5, 2024: medRxiv
#34
R Colin Carter, Zikun Yang, Tugba Akkaya-Hocagil, Sandra W Jacobson, Joseph L Jacobson, Neil C Dodge, H Eugene Hoyme, Steven H Zeisel, Ernesta M Meintjes, Caghan Kizil, Giuseppe Tosto
Ancestrally admixed populations are underrepresented in genetic studies of complex diseases, which are still dominated by European-descent populations. This is relevant not only from a representation standpoint but also because of admixed populations' unique features, including being enriched for rare variants, for which effect sizes are disproportionately larger than common polymorphisms. Furthermore, results from these populations may be generalizable to other populations. The South African Cape Coloured (SACC) population is genetically admixed, with one of the highest prevalences of fetal alcohol spectrum disorders (FASD) worldwide...
April 1, 2024: medRxiv
#35
JOURNAL ARTICLE
Charlotte E Eriksson, Gretchen H Roffler, Jennifer M Allen, Alex Lewis, Taal Levi
Wolves are assumed to be ungulate obligates, however, a recently described pack on Pleasant Island, Alaska USA, is persisting on sea otters and other marine resources without ungulate prey, violating this long-held assumption. We address questions about these wolves regarding their origin and fate, degree of isolation, risk of inbreeding depression, and diet specialization by individual and sex. We applied DNA metabarcoding and genotyping by amplicon sequencing using 957 scats collected from 2016 to 2022, and reduced representation sequencing of tissue samples to establish a detailed understanding of Pleasant Island wolf ecology and compare them with adjacent mainland wolves...
April 2024: Ecology and Evolution
#36
JOURNAL ARTICLE
Dongyan Zhao, Manoj Sapkota, Meng Lin, Craig Beil, Moira Sheehan, Stephanie Greene, Brian M Irish
Annual medic ( Medicago spp.) germplasm was collected from the Crimean Peninsula of Ukraine in 2008 to fill gaps in geographic coverage in the United States department of Agriculture, Agricultural Research Service, National Plant Germplasm System (NPGS) temperate-adapted forage legume collection. A total of 102 accessions across 10 Medicago species were collected. To assess genetic diversity, population structure, and to confirm taxonomic identities, the collections were phenotypically and genetically characterized...
2024: Frontiers in Plant Science
#37
JOURNAL ARTICLE
Xiang Zeng, Qing He, Yilan Li, Yong Zhou, Xiaoping Shao, Pei Hu, Jian Liang, Yudan Song, Chao Ma, Lijie Zhang, Limei Sun, Lei Luo
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: The inclusion of meningococcal vaccines in the National Immunization Program (NIP) over several years has significantly reduced the incidence of meningococcal meningitis in China to historic lows. Worldwide, there has been a diversification of meningococcal serogroups, leading to a shift in dominant serogroups in China from serogroup A to serogroups C and B, accompanied by a rise in reports of serogroups Y and W. WHAT IS ADDED BY THIS REPORT?: An outbreak of serogroup Y Neisseria meningitidis (Nm ) in a secondary vocational school involved a single confirmed severe case and 24 individuals with laboratory-confirmed Nm carriage...
March 22, 2024: China CDC weekly
#38
Lu Wang, Haiquan Xu, Jianbo Shu, Dandan Yan, Dong Li, Chunquan Cai
BACKGROUND: The gamma-aminobutyric acid (GABA) variant causes developmental and epileptic encephalopathy 45 (DEE45), an autosomal dominant disorder that results in oculocortical visual impairment, reduced muscle tone, psychomotor retardation, and epilepsy. Analysis of the clinical features and genetics of DEE45 may be helpful in complementing genotype-phenotype studies. CASE PRESENTATION: We collected peripheral blood samples from the affected children and parents and extracted genomic DNA...
2024: Frontiers in Pediatrics
#39
JOURNAL ARTICLE
Kishor Prabhakar Panzade, Kishor U Tribhuvan, Deepak V Pawar, Rahul Singh Jasrotia, Kishor Gaikwad, Monika Dalal, Ranjeet Ranjan Kumar, Madan Pal Singh, Om Prakash Awasthi, Jasdeep Chatrath Padaria
UNLABELLED: Ziziphus nummularia an elite heat-stress tolerant shrub, grows in arid regions of desert. However, its molecular mechanism responsible for heat stress tolerance is unexplored. Therefore, we analysed whole transcriptome of Jaisalmer (heat tolerant) and Godhra (heat sensitive) genotypes of Z. nummularia to understand its molecular mechanism responsible for heat stress tolerance. De novo assembly of 16,22,25,052 clean reads yielded 276,029 transcripts. A total of 208,506 unigenes were identified which contains 4290 and 1043 differentially expressed genes (DEG) in TGO (treated Godhra at 42 °C) vs...
March 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
#40
JOURNAL ARTICLE
Aya R Mohammed, Esmat I El-Said, Salah F Abd ElAal, Rania M Kamal
BACKGROUND: Food safety is a serious challenge in the face of increasing population and diminishing resources. Staphylococcus aureus is a critical foodborne pathogen characterized by its capability to secret a diverse range of heat-resistant enterotoxins. Antibiotic usage in dairy herds resulted in the occurrence of antimicrobial resistance (AMR) patterns among bacterial species, which were consequently transmitted to humans via dairy products. Lactic acid bacteria (LAB) produce bacteriocins, which provide an excellent source of natural antimicrobials with the further advantage of being environmentally friendly and safe...
January 2024: Open Veterinary Journal
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