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Antifugal resistant

Milica Petrović, Debora Bonvin, Heinrich Hofmann, Marijana Mionić Ebersold
Undecylenic acid (UA), known as antifungal agent, still cannot be used to efficiently modify commercial dental materials in such a way that this affects Candida . Actually, issues with Candida infections and fungal resistance compromise the use of Poly(methyl-methacrylate) (PMMA) as dental material. The challenge remains to turn PMMA into an antifugal material, which can ideally affect both sessile (attached) and planktonic (free-floating) Candida cells. We aimed to tackle this challenge by designing PMMA-UA composites with different UA concentrations (3-12%)...
January 8, 2018: International Journal of Molecular Sciences
Maria M Azevedo, Rita Teixeira-Santos, Ana P Silva, Luisa Cruz, Elisabete Ricardo, Cidália Pina-Vaz, Acácio G Rodrigues
During the last 30 years the incidence of fungal infections has increased dramatically. While the antifungal therapeutic options available are somewhat reduced, most pathogenic microorganisms have an incredible capacity to mutate and acquire resistance. In addition, multiple drugs are often required concomitantly to manage clinically complex disorders. The combination of antibiotics or other compounds with antifungal drugs, simultaneously or sequentially, is commonly adopted in clinical practice, although without a full knowledge of the consequences...
2015: Frontiers in Microbiology
Colombe Saillard, Antoine Sannini, Laurent Chow-Chine, Jean-Louis Blache, Jean-Paul Brun, Djamel Mokart
Febrile neutropenia in cancer patients is associated with a high mortality. Patients are frequently admitted to Intensive Care Unit (ICU) for severe sepsis or septic shock. Empirical antibiotic treatment, including monotherapy β-lactam covering Pseudomonas aeruginosa, must be prompt. The ICU management is slightly different, due to a particular microbial ecology. A standardized approach to obtain a microbiological documentation is the cornerstone in these patients, leading to an adapted antimicrobial treatment...
April 2015: Bulletin du Cancer
María Guadalupe Frías-de León, Gustavo Acosta-Altamirano, Esperanza Duarte-Escalante, José Enrique Martínez-Hernández, María de Los Ángeles Martínez-Rivera, María Del Rocío Reyes-Montes
Increase in the incidence of invasive aspergillosis has represented a difficult problem for management of patients with this infection due to its high rate of mortality, limited knowledge concerning its diagnosis, and therapeutic practice. The difficulty in management of patients with aspergillosis initiates with detection of the fungus in the specimens of immunosuppressed patients infected with Aspergillus fumigatus; in addition, difficulty exists in terms of the development of resistance to antifungals as a consequence of their indiscriminate use in prophylactic and therapeutic practice and to ignorance concerning the epidemiological data of aspergillosis...
January 2014: Cirugia y Cirujanos
Ahmed Moussa, Djebli Noureddine, Aissat Saad, Meslem Abdelmelek, Benhalima Abdelkader
OBJECTIVE: To evaluate the antifungal activity of four honeys of different types from Algeria against pathogenic yeast i.e. Candida albicans (C. albicans) and Rhodotorula sp. METHODS: Four Algeria honeys of different botanical origin were analyzed to test antifungal effect against C. albicans, and Rhodotorula sp. Different concentrations (undiluted, 10%, 30%, 50% and 70% w/v) of honey were studied in vitro for their antifugal activity using C. albicans and Rhodotorula sp...
July 2012: Asian Pacific Journal of Tropical Biomedicine
Qisheng Zhou, Ningning Cao, Nianquan Qiu, Benfeng Zhang, Nan Zhang, Xunli Liu
Streptomyces S24 has broad spectrum resistance to the Aspergillus in food and feed, such as Aspergillus flavus, Aspergillus niger, Asperegillus alutacells and so on. We studied the adsorption and desorption properties of antifungal substance from Streptomyces S24 on macroporous resins, screened the best elution solution and also investigated some physical and chemical characters of antifungal substance by determining the antifugal activity using oxford plate assay system. According to the analysis results, AB-8 resin offered the best adsorption and desorption capacity for antifungal substance and its saturated absorption capacity was 7...
March 2010: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
J Vráblik, J Masata, A Jedlicková, M Hájícková
OBJECTIVE: Aim of this study was to ascertain the prevalence of differrent candida strains and their sensitivity to different antimycotic treatment in women with vulvovaginal candidosis. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynecology, 1st Faculty of Medicine and the General Faculty Hospital, Charles University, Prague. UKLB, Clinical microbiology and ATB center, 1st Faculty of Medicine and the General Faculty Hospital, Charles University, Prague...
January 2007: Ceská Gynekologie
Min Zhao, Zeng-Tong Zhou, Wei-Dong Zhang
OBJECTIVE: To evaluate the sensitivity and resistance of pathogenic oral Candida spp. isolated from head and neck cancer patients treated with radiotherapy or chemotherapy to antifungal agents. To screen antifugal agents from Chinese traditional and herbal drugs by NCCLS M27-A2 method. METHODS: Using YBC Test Kit to identify 20 clinical oral Candida isolated from head and neck cancer patients treated with radiotherapy or chemotherapy. The in vitro susceptibilities of 20 oral Candida spp...
April 2006: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
István Pócsi, Rolf A Prade, Michel J Penninckx
Glutathione (GSH; gamma-L-glutamyl-L-cysteinyl-glycine), a non-protein thiol with a very low redox potential (E'0 = 240 mV for thiol-disulfide exchange), is present in high concentration up to 10 mM in yeasts and filamentous fungi. GSH is concerned with basic cellular functions as well as the maintenance of mitochondrial structure, membrane integrity, and in cell differentiation and development. GSH plays key roles in the response to several stress situations in fungi. For example, GSH is an important antioxidant molecule, which reacts non-enzymatically with a series of reactive oxygen species...
2004: Advances in Microbial Physiology
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