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https://www.readbyqxmd.com/read/29458073/establishment-and-validation-of-a-prediction-model-for-ischemic-stroke-risks-in-patients-with-type-2-diabetes
#1
Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin
AIMS: A risk scoring system for predicting ischemic stroke incidence may identify type 2 diabetes patients at high risk for ischemic stroke who can benefit from preventive intervention programs. Such a risk scoring system can serve as a benchmark to test novel putative risk factors. METHODS: The study adopted a retrospective cohort, including 28,124 Chinese patients with type 2 diabetes aged 30-84 years during 2001-2004. Participants were randomly assigned to the derivation and validation sets at a 2:1 ratio...
February 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29457840/population-pharmacokinetics-and-pharmacogenomics-of-apixaban-in-japanese-adult-patients-with-atrial-fibrillation
#2
Satoshi Ueshima, Daiki Hira, Yuuma Kimura, Ryo Fujii, Chiho Tomitsuka, Takuya Yamane, Yohei Tabuchi, Tomoya Ozawa, Hideki Itoh, Seiko Ohno, Minoru Horie, Tomohiro Terada, Toshiya Katsura
AIMS: This study aimed to analyse the effects of genetic polymorphisms in drug transporters and metabolising enzymes, and clinical laboratory data on the pharmacokinetic parameters of apixaban. METHODS: Data were collected from 81 Japanese patients with atrial fibrillation. Pharmacogenomic data were stratified by ABCB1, ABCG2, and CYP3A5 polymorphisms. The pharmacokinetic profile of apixaban was described by a one-compartment model with first-order absorption. Population pharmacokinetic analysis was conducted using non-linear mixed effect modelling (NONMEM™) program...
February 19, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29457410/-effect-of-admission-blood-urea-and-creatinine-levels-on-mortality-in-elderly-patients-with-hip-fracture
#3
Cheng-Yu Li, Xing-Chen Zhang, Xin Zheng, Min Rui, Sheng-Cheng Yao, Zi-Jiang Song, Feng-Chao Zhao, Kai-Jin Guo
OBJECTIVE: To observe the effect of admission blood urea and creatinine levels on mortality in elderly patients with hip fracture. METHODS: Form January 2013 to December 2014, 767 elder patients with hip fracture were treated in our hospital including 253 males and 514 females, aged from 65 to 96 years old with an average of(75.67±6.81) years old. According blood urea and creatinine levels, the 767 hip fracture patients were divided into four groups as follow: group A(blood urea>=5 mmol/L, creatinine>=70 μmol/L); group B (blood urea>=5 mmol/L, creatinine<70 μmol/L); group C (blood urea<5 mmol/L, creatinine>=70 μmol/L); group D(blood urea<5 mmol/L, creatinine<70 μmol/L)...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457371/validation-of-a-blood-marker-for-plasma-volume-in-endurance-athletes-during-a-live-high-train-low-altitude-training-camp
#4
Louisa M Lobigs, Laura A Garvican-Lewis, Victor L Vuong, Nicolin Tee, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
Altitude is a confounding factor within the Athlete's Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; hemoglobin concentration ([Hb]) and the OFF-score. Endurance athletes (n=34) completed a 21 night simulated live high: train low protocol (14h.d-1 at 3000m). Bloods were collected twice pre-altitude, at days 3, 8 and 15 at altitude and 1, 7, 21 and 42 days post-altitude...
February 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29457269/ambulatory-blood-pressure-monitoring-in-living-kidney-donors-what-changes-in-ten-years
#5
Serkan Feyyaz Yalin, Sinan Trabulus, Nurhan Seyahi, Mahir Cengiz, Mustafa Erdogan Cicik, Mehmet Riza Altiparmak
In renal transplantation, living donations have more significant benefits compared to cadaveric donations. However, a probable increase in blood pressure following donation should also be kept in mind. In this study, we investigated the long-term changes in blood pressure in living kidney donors using ambulatory blood pressure monitoring and we explored the e-GFR and albuminuria/proteinuria measurements at three time points. Twenty-eight living kidney donors and 39 healthy individuals were evaluated and compared at the baseline and later at the 10th year...
February 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29456238/remote-ischemic-postconditioning-ripc-of-the-upper-arm-results-in-protection-from-cardiac-ischemia-reperfusion-injury-following-primary-percutaneous-coronary-intervention-pci-for-acute-st-segment-elevation-myocardial-infarction-stemi
#6
Bangming Cao, Haipeng Wang, Chi Zhang, Ming Xia, Xiangjun Yang
BACKGROUND The aim of this study was to evaluate the role of remote ischemic postconditioning (RIPC) of the upper arm on protection from cardiac ischemia-reperfusion injury following primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). MATERIAL AND METHODS Eighty patients with STEMI were randomized into two groups: primary PCI (N=44) and primary PCI+RIPC (N=36). RIPC consisted of four cycles of 5 minutes of occlusion and five minutes of reperfusion by cuff inflation and deflation of the upper arm, commencing within one minute of the first PCI balloon dilatation...
February 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29456224/alport-s-syndrome-with-focal-segmental-glomerulosclerosis-lesion-pattern-to-recognize
#7
Afnan A Alsahli, Sara I Alshahwan, Amal O Alotaibi, Khaled O Alsaad, Nourah Aloudah, Mahfooz Farooqui, Abdullah A Al Sayyari
The association between Alport's syndrome (AS) and focal segmental glomerulosclerosis (FSGS) in the same patient is complex and rarely reported. We report a case of a 42-year-old male presenting with proteinuria, microscopic hematuria, elevated serum creatinine and hypertension with unremarkable physical examination apart from obesity. The renal biopsy showed well-established FSGS pattern of injury with mild interstitial fibrosis and tubular atrophy, while the electron microscopic examination demonstrated glomerular basement membranes (GBM) changes compatible with AS...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456219/descriptive-analysis-of-glomerulonephritis-by-histological-type-and-their-progression-among-adults-in-a-tertiary-care-center-in-sri-lanka
#8
Kawmadi W Gunawardena, Eranga S Wijewickrama, Carukshi Arambepola, Rushika D Lanerolle
Prevalence of different glomerulonephritides and their clinical course vary geographically. Our objectives are to assess the prevalence of different histological types of glomerulonephritis (GN) based on the light microscopic histology and to assess their progression according to histological type. A retrospective cross-sectional study was carried out among adult patients (>18 years) with a histological diagnosis of GN at the University Professorial Unit over a period of six months. Information including demographic data, renal biopsy findings, and progression of the disease through serum creatinine (SCr) level were collected through existing clinic records of consenting patients...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456206/c4d-negative-antibody-mediated-rejection-a-pathologist-s-perspective-and-clinical-outcome
#9
Lovelesh Kumar Nigam, Aruna V Vanikar, Kamal V Kanodia, Rashmi D Patel, Kamlesh S Suthar, Himanshu V Patel
Banff'13 update included C4d-antibody-mediated rejection (ABMR) as a separate entity responsible for graft dysfunction with limited clinical/prognostic implications. We present a retrospective study to determine the incidence and outcome of C4d-negative ABMR. A total of 987 renal allograft (RA) biopsies obtained from 987 RA recipients were studied from January 2013 to January 2016. All samples were subjected to light microscopy using standard stains and C4d immunohistochemistry on paraffin sections and reported according to modified Banff's criteria...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456203/effect-of-vitamin-e-on-reversibility-of-renal-function-following-discontinuation-of-colistin-in-rats-histological-and-biochemical-investigations
#10
Zohra Ghlissi, Ahmed Hakim, Hela Mnif, Rim Kallel, Khaled Zeghal, Tahiya Boudawara, Zouheir Sahnoun
This study was carried out to evaluate spontaneous renal regeneration after stopping colistin methanesulfonate (CMS), which induces tubular damage, and the curative effect of Vitamin E (vit E) in rats. Animals were given the following: sterile saline (n = 6), 300,000 IU/kg/ day of CMS (n = 24), or 450,000 IU/kg/day of CMS (n = 24) for seven days. Each CMS group was subdivided into four subgroups (n = 6) and sacrificed as follows: (i) 12 h after stopping CMS, (ii) two weeks after stopping CMS, (iii) two weeks after stopping treatment with vit E, and (iv) two weeks after stopping treatment with olive oil...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456202/contrast-induced-nephropathy-pathophysiology-risk-factors-and-prevention
#11
REVIEW
Mohammad A Hossain, Eric Costanzo, James Cosentino, Chirag Patel, Huzaif Qaisar, Vikas Singh, Taimoor Khan, Jennifer S Cheng, Arif Asif, Tushar J Vachharajani
Contrast-induced acute kidney injury is a common iatrogenic complication associated with increased health resource utilization and adverse outcomes, including short- and long-term mortality and accelerated progression of preexisting renal insufficiency. The incidence of contrast-induced nephropathy (CIN) has been reported to range from 0% to 24%. This wide range reported by the studies is due to differences in definition, background risk factors, type and dose of contrast medium used, and the frequency of other coexisting potential causes of acute renal failure...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456121/establishment-of-colonic-dialysis-model-in-uremic-rats-by-right-nephrectomy-and-left-partial-nephrectomy
#12
Abdol-Mohammad Kajbafzadeh, Nastaran Sabetkish, Shabnam Sabetkish
BACKGROUND: Conventional treatments for patients suffering with end-stage renal disease (ESRD) has several disadvantages, highlighting the importance of other reproducible modalities such as colonic dialysis (CD). OBJECTIVES: The aim was to establish a CD model in uremic rats and evaluate the effect of two different peritoneal dialysis (PD) solutions. METHODS: Thirty-two male Wistar rats were randomly divided into four groups. After right nephrectomy and left partial nephrectomy, a Malone antegrade continence enema (MACE) stoma was created...
February 7, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29455782/predictors-of-major-adverse-cardiac-events-following-elective-stenting-of-large-coronary-arteries
#13
Hassan Aghajani, Abdolhakim Alkamel, Akbar Shafiee, Arash Jalali, Younes Nozari, Hamidreza Pourhosseini, Seyed Ebrahim Kassaian, Mojtaba Salarifar, Alimohammad Hajizeinali, Alireza Amirzadegan, Mohammad Alidoosti, Farzad Masoudkabir, Ebrahim Nematipour
OBJECTIVE: Diameter of the affected coronary artery is an important predictor of restenosis and need for revascularization. In the present study, we investigated the frequency and potential risk factors for major adverse cardiac events following elective percutaneous coronary intervention (PCI) and stenting of large coronary arteries. METHODS: We reviewed the data of elective candidates of PCI on a large coronary artery who presented to our center. Demographic, clinical, angiographic and follow-up data of the eligible patients were retrieved from our databank...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455733/taxus-chinensis-ameliorates-diabetic-nephropathy-through-down-regulating-tgf-%C3%AE-1-smad-pathway
#14
Hong-Bo Weng, Wen-Ke Han, Yan-Wen Xiong, Zhou-Hui Jin, Zhen Lan, Cheng Liu, Xue-Mei Zhang, Wen Peng
Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. The rat DN model was established via feeding high fat diet for 4 weeks and subsequently injecting streptozotocin (30 mg·kg-1 body weight) intraperitoneally. The rats with blood glucose levels higher than 16...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29455546/effects-of-complete-water-fasting-and-regeneration-diet-on-kidney-function-oxidative-stress-and-antioxidants
#15
V Mojto, A Gvozdjakova, J Kucharska, Z Rausova, O Vancova, J Valuch
OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress. BACKGROUND: Therapeutic WF is considered a healing method. METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455427/variation-in-cardiac-markers-and-electrocardiographic-alterations-in-young-calves-naturally-infected-with-bovine-tropical-theileriosis
#16
Kapil Kumar Gupta, Mukesh Srivastava, Vikrant Sudan, Shanker Kumar Singh, Soumen Choudhury, Daya Shanker
The present study was designed to assess the deleterious effects of bovine tropical theileriosis on the cardiovascular system and the consequent myocardial involvement in young calves. Myocardial effects in parasitic diseases are often neglected. Hemolytic anemia, associated secondary hypoxia, and vasculitis are cardinal features of bovine theileriosis. In the present study, electrocardiogram (ECG) alongside serum cardiac troponin I (cTnI) and creatinine phosphokinase-myocardial band (CPK-MB) concentrations were analyzed in infected, treated, and control groups of young calves...
February 17, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29455335/evaluating-the-safety-and-tolerability-of-sacubitril-valsartan-for-hfref-managed-within-a-pharmacist-clinic
#17
Elizabeth K Pogge, Lindsay E Davis
OBJECTIVE: The objective of this research was to describe the use of pharmacist-managed sacubitril/valsartan therapy in a multi-center, outpatient cardiac group. BACKGROUND: Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNi), is a novel agent for the treatment of heart failure. An ARNi is recommended by national guidelines to be used in place of angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) therapy for patients who remain symptomatic...
February 17, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29454540/asymmetric-cellulose-triacetate-is-a-safe-and-effective-alternative-for-online-haemodiafiltration
#18
Marta Albalate Ramón, Patricia Martínez Miguel, Lourdes Bohorquez, Patricia de Sequera, Hanane Bouarich, Rafael Pérez-García, Diego Rodríguez Puyol, Guillermina Barril, Jose Antonio Sánchez Tomero, Martin Giorgi, Manuel Rafael Ramirez Chamond
BACKGROUND: In post-dilution haemodiafiltration only synthetic membranes have been used to date. Asymmetric cellulose triacetate (ATA™) is now available, whose characteristics are suitable for this technique. OBJECTIVES: To describe the in vivo performance and behaviour of this membrane, to identify its depurative effectiveness, use in clinical practice and its biocompatibility, both acute and after one month of treatment. METHODS: Observational prospective study of 23 patients who were dialysed for 4 weeks using an ATA™ membrane and who maintained their prior regimen...
February 14, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29454539/quantification-of-the-risk-of-urinary-calcium-stone-formation-in-the-urine-collected-at-2-times-of-the-day-in-a-group-of-children-studied-to-rule-out-prelithiasis
#19
Víctor M García Nieto, Xochitl Illian Pérez Bastida, María Salvador Cañibano, Victoria E García Rodríguez, Margarita Monge Zamorano, María Isabel Luis Yanes
BACKGROUND: Various genetic and environmental factors are involved in urolithiasis. The 2 most common metabolic abnormalities are the increase in urinary calcium and low urinary citrate excretion. The ratio calculated between the concentrations of both substances is a good risk marker for the formation of calcium stones. OBJECTIVES: To determine whether the risk of urinary calcium stone formation changes throughout the day in the same patient. METHODS: We studied 56 children (23V, 33M) to check if they had prelithiasis...
February 14, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29454528/continuous-infusion-versus-intermittent-bolus-injection-of-furosemide-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#20
REVIEW
Ka Ting Ng, Aslinah Velayit, Delton Kah Yeang Khoo, Amirah Mohd Ismail, Marzida Mansor
OBJECTIVE: Fluid overload is a common phenomenon seen in intensive care units (ICUs). However, there is no general consensus on whether continuous or bolus furosemide is safer or more effective in these hemodynamically unstable ICU patients. The aim of this meta-analysis was to examine the clinical outcomes of continuous versus bolus furosemide in a critically ill population in ICUs. DATA SOURCES: MEDLINE, EMBASE, PubMed, and the Cochrane Database of Systematic reviews were searched from their inception until June 2017...
January 10, 2018: Journal of Cardiothoracic and Vascular Anesthesia
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