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https://www.readbyqxmd.com/read/29917208/type-i-cardiorenal-syndrome-in-patients-with-acutely-decompensated-heart-failure-the-importance-of-new-renal-biomarkers
#1
A Atici, S Emet, R Cakmak, G Yuruyen, A Alibeyoglu, M Akarsu, Y Arman, M Kose, E Ozgun, M Ozcan, O Altun, I Onur, T Tukek
OBJECTIVE: Type 1 cardiorenal syndrome (CRS) is an acute renal failure in patients with acute decompensated heart failure with an incidence of 24% to 45%. The aim of our study was to investigate the significance of new renal biomarkers to predict type 1 CRS. PATIENTS AND METHODS: The study included 111 patients with acute decompensated heart failure diagnosed at the Istanbul Medical Faculty Emergency Department between 2014 and 2016, and 24 healthy volunteers. All urine samples were stored at -80°C after centrifugation...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917196/bml-111-inhibits-the-inflammatory-response-and-apoptosis-of-renal-tissue-in-rats-with-hemorrhagic-shock-by-inhibiting-the-mapk-pathway
#2
S-Y Chang, R-Q Sun, M Feng, Y-X Li, H-L Wang, Y-M Xu
OBJECTIVE: The effect of lipoxin receptor agonist BML-111 on acute kidney injury and AKI in rats with hemorrhagic shock (HS) and its mechanism were investigated. MATERIALS AND METHODS: A model of hemorrhagic shock in Sprague-Dawley (SD) rats was established, and recovered after 30 min of shock. 1 mg/kg BML-111 was intraperitoneally injected at the beginning of resuscitation in group BML-111. The concentration of serum creatinine, serum KIM-1 content, NGAL and inflammatory factors were detected...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917152/glomerular-filtration-rate-in-patients-with-multiple-sclerosis-undergoing-stem-cell-transplantation-and-treated-with-cyclophosphamide
#3
Alejandro Ruiz-Argüelles, Jose M Gastélum-Cano, Mariana A Méndez-Huerta, Alma B Rodríguez-Gallegos, Guillermo J Ruiz-Argüelles
Background: Glomerular filtration rate (GFR) is partially impaired in patients with multiple sclerosis (MS). When given chemotherapy before receiving hematopoietic stem-cell transplantation, GFR might be further deteriorated. Objective: To measure the effect of cyclophosphamide on GFR in patients with MS who undergo chemotherapy. Methods: We estimated GFR based on creatinine and cystatin C plasma concentrations in patients undergoing autologous hematopoietic stem-cell transplantation to treat their MS...
June 15, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29917063/sodium-intake-is-associated-with-endothelial-damage-biomarkers-and-metabolic-dysregulation
#4
Carmen Campino, Rene Baudrand, Carolina Valdivia, Cristian Carvajal, Andrea Vecchiola, Alejandra Tapia-Castillo, Alejandro Martínez-Aguayo, Hernán Garcia, Lorena García, Fidel Allende, Sandra Solari, Cristóbal Fuentes, Calos F Lagos, Maria Paulina Rojas, Doris Muñoz, Carlos Fardella
Background: Mounting evidence has associated high sodium intake with hypertension, cardiovascular disease and stroke. We investigated whether high sodium intake modulates the parameters of endothelial damage, inflammation and oxidative stress. Methods: We used a cross-sectional study design including 223 Chilean subjects (6.9-65.0 years old). We measured aldosterone, renin activity, cortisol, cortisone, adiponectin, leptin, hs-CRP, IL-6, TNF-alpha, PAI-1, metalloproteinase (MMP)-9 and MMP-2 activity and malondialdehyde (MDA)...
June 16, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29916985/impact-of-the-current-versus-the-previous-diagnostic-threshold-on-the-outcome-of-patients-with-borderline-changes-suspicious-for-t-cell-mediated-rejection-diagnosed-on-indication-biopsies
#5
Michael McRae, François Bouchard-Boivin, Stéphanie Béland, Réal Noël, Isabelle Côté, Isabelle Lapointe, Julie Lesage, Eva Latulippe, Julie Riopel, Dominick Santoriello, Syed A Husain, Olivier Désy, Isabelle Houde, Ibrahim Batal, Sacha A De Serres
BACKGROUND: Since the borderline changes suspicious for acute T-cell-mediated rejection (BL) category was broadened, there has been a debate regarding the right threshold for tubulitis (t) and interstitial inflammation (i) scores. METHODS: We studied a first cohort of 111 patients with BL found on an indication biopsy between 2006 and 2016 and compared those with scores of t1i0 (BLt1i0) to those with higher scores (BL≥t1i1). A second cohort of 56 patients with BL was used for external validation...
June 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29916559/features-of-atrial-fibrillation-in-wild-type-transthyretin-cardiac-amyloidosis-a-systematic-review-and-clinical-experience
#6
Yuliya Y Mints, Gheorghe Doros, John L Berk, Lawreen H Connors, Frederick L Ruberg
AIMS: Wild-type transthyretin (ATTRwt) cardiac amyloidosis has emerged as an important cause of heart failure in the elderly. Atrial fibrillation (AF) commonly affects older adults with heart failure and is associated with reduced survival, but its role in ATTRwt is unclear. We sought to explore the clinical impact of AF in ATTRwt. METHODS AND RESULTS: Patients with biopsy-proven ATTRwt cardiac amyloidosis (n = 146) were retrospectively identified, and clinical, echocardiographic, and biochemical data were collected...
June 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29916133/three-dimensional-indices-of-renal-perfusion-in-normal-pregnancy-and-pre-eclampsia
#7
Amanda Ali, Susan Addley, Stephen Ong
INTRODUCTION: We compared renal perfusion in normal pregnant women and women with pre-eclampsia using three-dimensional (3D) ultrasound. We measured the flow index (FI), vascular index (VI) and vascularisation flow index (VFI) which are believed to reflect vascularity and flow intensity. METHODS: Fourteen patients with normal pregnancy and 16 patients with pre-eclampsia were recruited. Imaging was conducted using a Voluson E8 machine and a 6-MHz trans-abdominal probe...
June 18, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29915811/related-factors-of-early-mortality-in-young-adults-with-cerebral-hemorrhage
#8
Hong Xia Zhou, Nina Hao, Xiao Lin Xu
Background: The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking. Methods: We retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan-Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29915248/effect-of-tyrosine-kinase-inhibitors-on-renal-handling-of-creatinine-by-mate1
#9
Saki Omote, Natsumi Matsuoka, Hiroshi Arakawa, Takeo Nakanishi, Ikumi Tamai
Creatinine is actively secreted across tubular epithelial cells via organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1). We previously showed that the tyrosine kinase inhibitor (TKI) crizotinib inhibits OCT2-mediated transport of creatinine. In the present work, we examined the inhibitory potency of TKIs, including crizotinib, on MATE1-mediated transport of creatinine. Then, we used the kinetic parameters estimated in this and the previous work to predict the potential impact of TKIs on serum creatinine level (SCr) via reversible inhibition of creatinine transport...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914948/population-pharmacokinetic-study-of-amoxicillin-treated-burn-patients-hospitalized-at-a-tertiary-swiss-centre
#10
Anne Fournier, Sylvain Goutelle, Yok-Ai Que, Philippe Eggimann, Olivier Pantet, Farshid Sadeghipour, Pierre Voirol, Chantal Csajka
Objectives: To investigate the population pharmacokinetics (PK) of amoxicillin in ICU burn patients and the optimal dosage regimens. METHODS: Prospective study involving 21 consecutive burn patients receiving amoxicillin. PK data were analysed using non-linear mixed effects modelling. Monte-Carlo simulations assessed the influence of various amoxicillin dosage regimens with identified covariates on the probability to achieve a target (PTA) value of time during which free amoxicillin concentrations in plasma exceeded the minimal inhibitory concentration ( f T>MIC)...
June 18, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29914404/significantly-different-clinical-features-between-hypertriglyceridemia-and-biliary-acute-pancreatitis-a-retrospective-study-of-730-patients-from-a-tertiary-center
#11
Xiaoyao Li, Lu Ke, Jie Dong, Bo Ye, Lei Meng, Wenjian Mao, Qi Yang, Weiqin Li, Jieshou Li
BACKGROUND: Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between hypertriglyceridemia and biliary acute pancreatitis have not been well described. METHODS: This retrospective study enrolled 730 acute pancreatitis patients from July 1, 2013 to October 1, 2016 in Jinling Hospital. The causes of the study patients were defined according to specific diagnostic criteria...
June 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29914235/serum-s100b-nse-and-gria1-levels-as-neurological-biomarkers-in-lead-exposure
#12
Esra Fırat Oğuz, Fatma Meriç Yılmaz, Engin Tutkun, Ömer Hınç Yılmaz, Müjgan Ercan, Sevilay Sezer
Background/aim: The central nervous system is one of the major targets in lead exposure. Biomarkers for the diagnosis and follow-up of lead exposure have not been identified. In this study, serum S100B, neuron-specific enolase (NSE), and glutamate receptor 1 (GRIA1) levels were determined as possible biomarkers for lead neurotoxicity. Material and methods: Twenty-five subjects with chronic lead exposure and 25 controls were included in the study. NSE and S100B were measured by electrochemiluminescence immunoassay with a Cobas E601 analyzer...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913234/the-ameliorative-effects-of-boron-against-acrylamide-induced-oxidative-stress-inflammatory-response-and-metabolic-changes-in-rats
#13
Ulas Acaroz, Sinan Ince, Damla Arslan-Acaroz, Zeki Gurler, Ismail Kucukkurt, Hasan Hüseyin Demirel, Halil Ozancan Arslan, Nuray Varol, Kui Zhu
Acrylamide (ACR) is a hazardous substance associated with the accumulation of excessive reactive oxygen species and causes oxidative stress. Presence of ACR in foods leads to public health concerns due to its known neurotoxic, genotoxic, and carcinogenic effects. The present study investigated the ameliorative effects of boron (B) against ACR exposed rats. Forty Wistar albino male rats, fed with low-boron diet, were randomly and equally allocated into 5 groups. The control group was orally treated with physiological saline as placebo, the second group was orally given 15 mg/kg ACR...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29912750/177lu-dotatate-therapy-in-patients-with-neuroendocrine-tumours-including-high-grade-who-g3-neuroendocrine-tumours-response-to-treatment-and-long-term-survival-update
#14
Emre Demirci, Levent Kabasakal, Turkay Toklu, Meltem Ocak, Onur E Şahin, Nalan Alan-Selcuk, Ahmet Araman
PURPOSE: Upon diagnosis, distant metastases are encountered in 21-50% of neuroendocrine tumours (NETs). However, few systemic treatment options are available for the well-differentiated NETs in the metastatic stage. Lu-DOTATATE is one of the most effective treatments in this limited patient group. We retrospectively investigated its efficacy and effect on the survival in patients with both well-differentiated and grade III NETs who had high uptake in pretherapeutic Ga-DOTATATE PET/computed tomography scans...
June 15, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29912602/comparing-immunoglobulin-a-vasculitis-henoch-sch%C3%A3-nlein-purpura-in-children-and-adults-a-single-centre-study-from-turkey
#15
E D Batu, A Sarı, A Erden, H E Sönmez, B Armağan, U Kalyoncu, Ö Karadağ, Y Bilginer, A Akdoğan, S Kiraz, S Özen
OBJECTIVE: Immunoglobulin A vasculitis/Henoch-Schönlein purpura (IgAV/HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA. It is the most common primary systemic vasculitis of childhood and is much less common in adults. Our aim was to investigate the differences and similarities between adult and paediatric patients with IgAV/HSP. METHOD: We retrospectively evaluated the medical records of 35 adult and 159 paediatric (˂ 18 years old) patients with a clinical diagnosis of IgAV/HSP who were seen at the Departments of Rheumatology and Pediatric Rheumatology, Hacettepe University, Ankara, Turkey...
June 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29912597/cystatin-c-as-a-predictor-of-mortality-in-elderly-patients-with-chronic-kidney-disease
#16
Sebastjan Bevc, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. METHODS: Fifty eight adult Caucasian patients, older than 65 years, without known malignancy, thyroid disease and/or not on steroid therapy were enrolled in the study...
June 18, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29912346/a-unidimensional-diffusion-model-applied-to-uremic-toxin-kinetics-in-haemodiafiltration-treatments
#17
Miquel Gomez, Francisco Maduell
Kinetic modelling in haemodialysis is usually based upon the resolution of volume-defined compartment models. The interaction among these compartments is described by purely diffusive processes. In this paper we present an alternative kinetic model for uremic toxins in post-dilutional haemodiafiltration treatments by means of a unidimensional diffusion equation. A wide range of solutes such as urea, creatinine, $\beta _{2}$-microglobulin, myoglobin and prolactin were studied by imposing appropriate boundary and initial conditions in a virtual [0,1] domain...
June 15, 2018: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29911959/conversion-from-steroid-to-everolimus-in-maintenance-kidney-transplant-recipients-with-posttransplant-diabetes-mellitus
#18
Koji Nanmoku, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Takashi Yagisawa
OBJECTIVES: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy. MATERIALS AND METHODS: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg)...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29911044/advanced-diabetic-nephropathy-with-clean-eyes-an-extreme-phenotype
#19
Debmalya Sanyal, Sudip Chatterjee
Introduction: It is generally accepted that renal and eye changes in diabetes are concordant. There are however a fair number of patients with diabetes who have end-stage renal disease (ESRD) without any of the typical eye changes. The present study highlights the discordance between retinopathy and nephropathy and describes a series of patients of long-standing diabetes undergoing renal transplant who had little or no evidence of retinopathy. Methods: All patients with ESRD undergoing renal transplants underwent comprehensive fundus evaluation including dilated indirect ophthalmoscopy, slit lamp biomicroscopy, and fundus photography...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911024/metformin-reduces-insulin-resistance-and-the-tendency-toward-hyperglycaemia-and-dyslipidaemia-in-dogs-with-hyperadrenocorticism
#20
Diego Daniel Miceli, Patricia Noemi Vidal, María Fernanda Cabrera Batter, Omar Pignataro, Victor Alejandro Castillo
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia, dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of the skeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control of metabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly divided into two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h)...
2018: Open Veterinary Journal
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