Larissa Daniele Bobermin, Daniele Schauren da Costa, Aline Daniel Moreira de Moraes, Vanessa Fernanda da Silva, Giancarlo Tomazzoni de Oliveira, Patrícia Sesterheim, Ana Carolina Tramontina, Luiz Augusto Basso, Guilhian Leipnitz, André Quincozes-Santos, Carlos-Alberto Gonçalves
Astrocytes are glial cells that play key roles in neuroinflammation, which is a common feature in diabetic encephalopathy and aging process. Metformin is an antidiabetic compound that shows neuroprotective properties, including in inflammatory models, but astroglial signaling pathways involved are still poorly known. Interferons α/β are cytokines that participate in antiviral responses and the lack of their signaling increases susceptible to viral infections. Here, we investigated the effects of metformin on astrocytes from hypothalamus, a crucial brain region related to inflammatory processes...
April 18, 2024: Biochimie