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https://www.readbyqxmd.com/read/27906582/fiat-deletion-increases-bone-mass-but-does-not-prevent-high-fat-diet-induced-metabolic-complications
#1
Bahareh Hekmatnejad, Vionnie W C Yu, William Addison, Vice Mandic, Martin Pellicelli, Alice Arabian, René St-Arnaud
FIAT (Factor Inhibiting ATF4-mediated Transcription) interacts with ATF4 to repress its transcriptional activity. We performed a phenotypic analysis of Fiat-deficient male mice (Fiat(-/Y)) at 8 and 16 weeks of age. Fiat(-/Y) mice appeared normal at birth and weight gain was comparable between genotypes. μCT analysis of proximal femur demonstrated 46% and 13% age-dependent increases in trabecular bone volume and thickness, respectively, in Fiat(-/Y) mice. Cortical bone measurements at the femoral midshaft revealed a significant increase in cortical thickness in older Fiat(-/Y) mice...
December 1, 2016: Endocrinology
https://www.readbyqxmd.com/read/27902413/methanosarcina-acetivorans-utilizes-a-single-nadph-dependent-thioredoxin-system-and-contains-additional-thioredoxin-homologs-with-distinct-functions
#2
Addison C McCarver, Faith H Lessner, Jose M Soroeta, Daniel J Lessner
The thioredoxin system plays a central role in the intracellular redox maintenance in the majority of cells. The canonical system is comprised of an NADPH-dependent thioredoxin reductase (TrxR) that reduces the disulfide reductase thioredoxin (Trx). Although Trx is encoded in almost all sequenced genomes of methanogens, its incorporation into their unique physiology is not well understood. Methanosarcina acetivorans contains a single TrxR (MaTrxR) and seven Trx (MaTrx1-7) homologs. We previously showed that MaTrxR and at least MaTrx7 comprise a functional NADPH-dependent thioredoxin system...
November 29, 2016: Microbiology
https://www.readbyqxmd.com/read/27899384/rifampicin-induced-adrenal-crisis-in-a-patient-with-tuberculosis-a-therapeutic-challenge
#3
Nicholas Denny, Sarika Raghunath, Praveen Bhatia, Muntasir Abdelaziz
A 55-year-old Indian man presented with productive cough and a large left pleural effusion. Pleural fluid culture grew Mycobacterium tuberculosis, and he was started on antituberculosis therapy. One week later, the patient presented to hospital with drowsiness, dehydration and hypotension. He was transferred to critical care and only improved after starting hydrocortisone and stopping rifampicin. His short synACTHen test subsequently confirmed primary adrenal insufficiency, and a CT of the abdomen showed bilateral adrenal enlargement...
November 29, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27898397/multicenter-performance-evaluation-of-a-second-generation-cortisol-assay
#4
Michael Vogeser, Jürgen Kratzsch, Yoon Ju Bae, Mathias Bruegel, Uta Ceglarek, Tom Fiers, Alexander Gaudl, Hedwig Kurka, Christoph Milczynski, Cristina Prat Knoll, Anna C Suhr, Daniel Teupser, Ingrid Zahn, Richard E Ostlund
BACKGROUND: Untreated disorders of the adrenocortical system, such as Cushing's or Addison's disease, can be fatal, and accurate quantification of a patient's cortisol levels is vital for diagnosis. The objective of this study was to assess the analytical performance of a new fully-automated Elecsys® Cortisol II assay (second generation) to measure cortisol levels in serum and saliva. METHODS: Four European investigational sites assessed the intermediate precision and reproducibility of the Cortisol II assay (Roche Diagnostics) under routine conditions...
November 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27889833/factors-associated-with-expression-of-extrapyramidal-symptoms-in-users-of-atypical-antipsychotics
#5
Susana Barbosa Ribeiro, Aurigena Antunes de Araújo, Caroline Addison Xavier Medeiros, Katarina Melo Chaves, Maria do Socorro Costa Feitosa Alves, Antonio Gouveia Oliveira, Rand Randall Martins
PURPOSE: The aim of this study was to investigate factors associated with the occurrence of extrapyramidal symptoms (EPS) in users of second-generation antipsychotics (SGA). METHODS: Observational cross-sectional study based on a random sample of subjects from three outpatient clinics. Inclusion criteria were age between 18 and 65 years, of both genders, with a diagnosis of schizophrenia and under the use of a single SGA agent. Subjects who had received i.m. long-acting antipsychotics in the past were excluded...
November 26, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27886210/physical-activity-energy-expenditure-and-defense-of-body-weight-in-melanocortin-4-receptor-deficient-male-rats
#6
Tariq I Almundarij, Mark E Smyers, Addison Spriggs, Lydia A Heemstra, Lisa Beltz, Eric Dyne, Caitlyn Ridenour, Colleen M Novak
Melanocortin 4 receptor (MC4R) variants contribute to human obesity, and rats lacking functional MC4R (Mc4r(K314X/K314X)) are obese. We investigated the hypothesis that low energy expenditure (EE) and physical activity contribute to this obese phenotype in male rats, and determined whether lack of functional MC4R conferred protection from weight loss during 50% calorie restriction. Though Mc4r(K314X/K314X) rats showed low brown adipose Ucp1 expression and were less physically active than rats heterozygous for the mutation (Mc4r(+/K314X)) or wild-type (Mc4r(+/+)) rats, we found no evidence of lowered EE in Mc4r(K314X/K314X) rats once body weight was taken into account using covariance...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870550/clinical-and-immunological-characteristics-of-autoimmune-addison-s-disease-a-nationwide-swedish-multicenter-study
#7
Frida Dalin, Gabriel Nordling Eriksson, Per Dahlqvist, Åsa Hallgren, Jeanette Wahlberg, Olov Ekwall, Stefan Söderberg, Johan Rönnelid, Per Olcén, Ola Winqvist, Sergiu-Bogdan Catrina, Berit Kriström, Maria Laudius, Magnus Isaksson, Maria Halldin Stenlid, Jan Gustafsson, Gennet Gebre-Medhin, Sigridur Björnsdottir, Annika Janson, Anna-Karin Åkerman, Jan Åman, Karel Duchen, Ragnhildur Bergthorsdottir, Gudmundur Johannsson, Emma Lindskog, Mona Landin-Olsson, Maria Elfving, Erik Waldenström, Anna-Lena Hulting, Olle Kämpe, Sophie Bensing
CONTEXT: Studies on clinical and immunological features of Autoimmune Addison's disease (AAD) are needed to understand the disease burden and increased mortality. OBJECTIVE: To provide upgraded data on autoimmune comorbidities, replacement therapy, autoantibody profiles and cardiovascular risk factors. DESIGN, SETTING AND PARTICIPANTS: Cross sectional, population-based study. 660 AAD patients were included utilizing the Swedish Addison Registry (SAR) 2008-2014...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27864587/evaluation-of-the-genetic-basis-of-primary-hypoadrenocorticism-in-standard-poodles-using-snp-array-genotyping-and-whole-genome-sequencing
#8
Steven G Friedenberg, Katharine F Lunn, Kathryn M Meurs
Primary hypoadrenocorticism, also known as Addison's disease, is an autoimmune disorder leading to the destruction of the adrenal cortex and subsequent loss of glucocorticoid and mineralocorticoid hormones. The disease is prevalent in Standard Poodles and is believed to be highly heritable in the breed. Using genotypes derived from the Illumina Canine HD SNP array, we performed a genome-wide association study of 133 carefully phenotyped Standard Poodles (61 affected, 72 unaffected) and found no markers significantly associated with the disease...
November 18, 2016: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/27852503/ultrasonic-structural-health-monitoring-to-assess-the-integrity-of-spinal-growing-rods-in%C3%A2-vitro
#9
Matthew E Oetgen, Addison Goodley, Byungseok Yoo, Darryll J Pines, Adam H Hsieh
BACKGROUND: Rod fracture is a common complication of growing rods and can result in loss of correction, patient discomfort, and unplanned revision surgery. The ability to quantitate rod integrity at each lengthening would be advantageous to avoid this complication. We investigate the feasibility of applying structural health monitoring to evaluate the integrity of growing rods in vitro. METHODS: Single-rod titanium 4.5-mm growing rod constructs (n = 9), one screw proximally and one distally connected by in-line connectors, were assembled with pedicle screws fixed in polyethylene blocks...
January 2016: Spine Deformity
https://www.readbyqxmd.com/read/27850305/666-evaluation-of-short-course-antimicrobials-for-intra-abdominal-infections-in-critically-ill-patients
#10
Susan Dickey, Kelli Rumbaugh, Addison May
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849563/effect-of-intensive-versus-standard-clinic-based-hypertension-management-on-ambulatory-blood-pressure-results-from-the-sprint-systolic-blood-pressure-intervention-trial-ambulatory-blood-pressure-study
#11
Paul E Drawz, Nicholas M Pajewski, Jeffrey T Bates, Natalie A Bello, William C Cushman, Jamie P Dwyer, Lawrence J Fine, David C Goff, William E Haley, Marie Krousel-Wood, Andrew McWilliams, Dena E Rifkin, Yelena Slinin, Addison Taylor, Raymond Townsend, Barry Wall, Jackson T Wright, Mahboob Rahman
: The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP) is unknown. The goal of the SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory BP ancillary study was to evaluate the effect of intensive versus standard clinic-based BP targets on ambulatory BP. Ambulatory BP was obtained within 3 weeks of the 27-month study visit in 897 SPRINT participants. Intensive treatment resulted in lower clinic systolic BP (mean difference between groups=16...
November 14, 2016: Hypertension
https://www.readbyqxmd.com/read/27849097/recent-advances-in-well-defined-late-transition-metal-complexes-that-make-and-or-break-c-n-c-o-and-c-s-bonds
#12
REVIEW
Addison N Desnoyer, Jennifer A Love
Chemical transformations that result in either the formation or cleavage of carbon-heteroatom bonds are among the most important processes in the chemical sciences. Herein, we present a review on the reactivity of well-defined, late-transition metal complexes that result in the making and breaking of C-N, C-O and C-S bonds via fundamental organometallic reactions, i.e. oxidative addition, reductive elimination, insertion and elimination reactions. When appropriate, emphasis is placed on structural and spectroscopic characterization techniques, as well as mechanistic data...
November 16, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27845146/do-thermal-tolerances-and-rapid-thermal-responses-contribute-to-the-invasion-potential-of-bactrocera-dorsalis-diptera-tephritidae
#13
Welma Pieterse, John S Terblanche, Pia Addison
Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) has shown remarkable range expansion over the past 10years and invaded several new continents including Africa. Here we report results of a detailed assessment of acute high and low temperature survival ability and the plasticity thereof, to test the hypothesis that traits of the thermal niche have contributed to the species' invasion ability. We also assess life-stage-related variation of thermal tolerances to determine potential stage-related environmental sensitivity...
November 12, 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27837079/supporting-the-treatment-of-addison-s-disease-in-dogs
#14
(no author information available yet)
No abstract text is available yet for this article.
November 12, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27828764/antimicrobial-stewardship-a-call-to-action-for-surgeons
#15
Massimo Sartelli, Therese M Duane, Fausto Catena, Jeffrey M Tessier, Federico Coccolini, Lillian S Kao, Belinda De Simone, Francesco M Labricciosa, Addison K May, Luca Ansaloni, John E Mazuski
Despite current antimicrobial stewardship programs (ASPs) being advocated by infectious disease specialists and discussed by national and international policy makers, ASPs coverage remains limited to only certain hospitals as well as specific service lines within hospitals. The ASPs incorporate a variety of strategies to optimize antimicrobial agent use in the hospital, yet the exact set of interventions essential to ASP success remains unknown. Promotion of ASPs across clinical practice is crucial to their success to ensure standardization of antimicrobial agent use within an institution...
December 2016: Surgical Infections
https://www.readbyqxmd.com/read/27813051/salivary-cortisol-and-cortisone-do-not-appear-to-be-useful-biomarkers-for-monitoring-hydrocortisone-replacement-in-addison-s-disease
#16
I L Ross, M Lacerda, T S Pillay, D J Blom, G Johannsson, J A Dave, N S Levitt, D Haarburger, J-S van der Walt
Salivary cortisol has been used to monitor hydrocortisone replacement in patients with Addison's disease (AD). Since salivary cortisol is metabolised to salivary cortisone, it may be an adjunctive analyte to assess adequacy of hydrocortisone replacement in patients with AD. We aimed to characterise the exposure of salivary cortisol and cortisone in patients and healthy controls. We measured salivary cortisol and cortisone by liquid chromatography-tandem mass spectrometry and constructed a day curve (08:00 until 24:00 h) with 16 time points in 25 AD patients taking their usual hydrocortisone dose and in 26 healthy controls...
November 3, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27811411/new-homodinuclear-tris-3-alkylpyrazolyl-borate-complexes-of-co-ii-and-ni-ii-with-a-tetraacetylethane-dianion-as-a-bridging-ligand
#17
Elena A Mikhalyova, Swiatoslaw Trofimenko, Matthias Zeller, Anthony W Addison, Vitaly V Pavlishchuk
Polynuclear complexes and coordination polymers of 3d metals have attracted significant interest evoked by a number of their unique properties. One of the most common approaches to the directed synthesis of coordination polymers is the linking of pre-prepared discrete coordination units by polydentate ligands. The formation of polynuclear complexes is usually a spontaneous process and precise prediction of the products of such reactions is virtually impossible in most cases. Tris(pyrazolyl)borates (Tp) act as tripodal `capping' ligands which form stable complexes with 3d metal ions...
November 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27810905/management-of-endocrine-disease-regenerative-therapies-in-autoimmune-addison-s-disease-aad
#18
Earn Hui Gan, Simon Hs Pearce
The treatment for autoimmune Addison's disease (AAD) has remained virtually unchanged in the last 60 years. Most patients have symptoms that are relatively well controlled with exogenous steroid replacement but there may be persistent symptoms, recurrent adrenal crisis and poor quality of life, despite good compliance with optimal current treatments. Treatment with conventional exogenous steroid therapy is also associated with premature mortality, increased cardiovascular risk and complications related to excessive steroid replacement...
November 3, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27807919/extended-exome-sequencing-identifies-bach2-as-a-novel-major-risk-locus-for-addison-s-disease
#19
D Eriksson, M Bianchi, N Landegren, J Nordin, F Dalin, A Mathioudaki, G N Eriksson, L Hultin-Rosenberg, J Dahlqvist, H Zetterqvist, Å Karlsson, Å Hallgren, F H G Farias, E Murén, K M Ahlgren, A Lobell, G Andersson, K Tandre, S R Dahlqvist, P Söderkvist, L Rönnblom, A-L Hulting, J Wahlberg, O Ekwall, P Dahlqvist, J R S Meadows, S Bensing, K Lindblad-Toh, O Kämpe, G R Pielberg
BACKGROUND: Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. METHODS: To understand the genetic background of Addison's disease, we utilized the extensively characterized patients of the Swedish Addison Registry. We developed an extended exome capture array comprising a selected set of 1853 genes and their potential regulatory elements, for the purpose of sequencing 479 patients with Addison's disease and 1394 controls...
November 2, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27803450/olmesartan-prevented-intra-articular-inflammation-induced-by-zymosan-in-rats
#20
Gerlane Coelho Bernardo Guerra, Marília Stefani Souza de Menezes, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo Júnior, Caroline Addison Carvalho Xavier de Medeiros
The objective of this study was to study the effect of olmesartan medoxomil (OLM), an antihypertensive drug, on intra-articular inflammation induced by zymosan (Zy) in Wistar rats. Intra-articular inflammation was induced in the right knees of rats by 1 mg Zy dissolved in saline. The animals were divided into the following groups: saline only (oral saline and intra-articular saline); Zy only (intra-articular Zy and oral saline), and intra-articular Zy and oral OLM (5, 15, or 30 mg/kg) or diclofenac sodium (SD; 100 mg/kg)...
2016: Biological & Pharmaceutical Bulletin
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