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https://www.readbyqxmd.com/read/29773636/draft-genome-sequence-of-a-candidatus-liberibacter-europaeus-strain-assembled-from-broom-psyllids-arytainilla-spartiophila-from-new-zealand
#1
Rebekah A Frampton, Sarah M Thompson, Falk Kalamorz, Charles David, Shea M Addison, Grant R Smith
Here, we report the draft genome sequence of " Candidatus Liberibacter europaeus" ASNZ1, assembled from broom psyllids ( Arytainilla spartiophila ) from New Zealand. The assembly comprises 15 contigs, with a total length of 1.33 Mb and a G+C content of 33.5%.
May 17, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29750723/outcomes-of-sphincter-pharyngoplasty-in-the-cleft-population
#2
Ritwik Grover, Addison Barnett, Antonio Rampazzo, Frank Papay, Bahar Bassiri Gharb
INTRODUCTION: Sphincter pharyngoplasty (SP) is becoming increasingly popular for correction of velopharyngeal insufficiency (VPI) after cleft palate repair because of high success rate, low incidence of postoperative obstructive sleep apnea (OSA), and ease of revision in case of failure. This study is a meta-analysis of SP outcomes, reasons for failure, and revision strategies. METHODS: A comprehensive review of the literature on SP outcomes was conducted. Sphincter pharyngoplasty failure was defined as persistent hypernasality, incomplete velopharyngeal port (VP) closure on instrumental evaluation with concomitant VPI, or nonresolving hyponasality and/or OSA persisting >3 months after surgery...
May 10, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29739281/the-association-between-adverse-child-health-psychological-educational-and-social-outcomes-and-nondependent-parental-substance-a-rapid-evidence-assessment
#3
Ruth McGovern, Eilish Gilvarry, Michelle Addison, Hayley Alderson, Emma Geijer-Simpson, Raghu Lingam, Debbie Smart, Eileen Kaner
BACKGROUND: Between 5% and 30% of children in high-income countries live with a substance misusing parent, the majority of which is below dependent levels. However, little is understood about the impact of nondependent parental substance misuse upon children. METHODS: We searched the international literature using rigorous systematic methods to identify studies examining parental substance misuse and adverse outcomes in children. The inclusion criteria were cross-sectional, longitudinal, case-control, and cohort studies; of children aged 0-18 years whose parents are high-risk substance misusers; reporting on their health, psychological, substance use, educational, and social outcomes...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29731513/a-global-mitigation-hierarchy-for-nature-conservation
#4
William N S Arlidge, Joseph W Bull, Prue F E Addison, Michael J Burgass, Dimas Gianuca, Taylor M Gorham, Céline Jacob, Nicole Shumway, Samuel P Sinclair, James E M Watson, Chris Wilcox, E J Milner-Gulland
Efforts to conserve biodiversity comprise a patchwork of international goals, national-level plans, and local interventions that, overall, are failing. We discuss the potential utility of applying the mitigation hierarchy, widely used during economic development activities, to all negative human impacts on biodiversity. Evaluating all biodiversity losses and gains through the mitigation hierarchy could help prioritize consideration of conservation goals and drive the empirical evaluation of conservation investments through the explicit consideration of counterfactual trends and ecosystem dynamics across scales...
May 1, 2018: Bioscience
https://www.readbyqxmd.com/read/29731343/cell-identity-switching-regulated-by-retinoic-acid-signaling-maintains-homogeneous-segments-in-the-hindbrain
#5
Megan Addison, Qiling Xu, Jordi Cayuso, David G Wilkinson
The patterning of tissues to form subdivisions with distinct and homogeneous regional identity is potentially disrupted by cell intermingling. Transplantation studies suggest that homogeneous segmental identity in the hindbrain is maintained by identity switching of cells that intermingle into another segment. We show that switching occurs during normal development and is mediated by feedback between segment identity and the retinoic acid degrading enzymes, cyp26b1 and cyp26c1. egr2, which specifies the segmental identity of rhombomeres r3 and r5, underlies the lower expression level of cyp26b1 and cyp26c1 in r3 and r5 compared with r2, r4, and r6...
April 30, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29730792/using-measures-of-wellbeing-for-impact-evaluation-proof-of-concept-developed-with-an-indigenous-community-undertaking-land-management-programs-in-northern-australia
#6
Silva Larson, Natalie Stoeckl, Diane Jarvis, Jane Addison, Sharon Prior, Michelle Esparon
Combining insights from literature on the Theory of Change, Impact Evaluation, and Wellbeing, we develop a novel approach to assessing impacts. Intended beneficiaries identify and rate factors that are important to their wellbeing, their satisfaction with those factors now, and before an intervention. Qualitative responses to questions about perceived changes and causes of change are linked to quantitative data to draw inferences about the existence and/or importance of impact(s). We use data from 67 Ewamian people, in a case study relating to Indigenous land management, to provide proof of concept...
May 5, 2018: Ambio
https://www.readbyqxmd.com/read/29720404/towards-a-mechanistic-and-physiological-understanding-of-a-ferredoxin-disulfide-reductase-from-the-domains-archaea-and-bacteria
#7
Divya Prakash, Karim A Walters, Ryan J Martinie, Addison C McCarver, Adepu K Kumar, Daniel J Lessner, Carsten Krebs, John H Golbeck, James G Ferry
Disulfide reductases reduce other proteins and are critically important for cellular redox signaling and homeostasis. Methanosarcina acetivorans is a methane-producing microbe from the domain Archaea that produces a ferredoxin:disulfide reductase (FDR) for which the crystal structure has been reported, yet its biochemical mechanism and physiological substrates are unknown. FDR and the extensively characterized plant-type ferredoxin:thioredoxin reductase (FTR) belong to a distinct class of disulfide reductases that contain a unique active-site [4Fe-4S] cluster...
May 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29716791/predictors-of-30-day-readmission-following-pancreatic-surgery-a-retrospective-review
#8
Leo I Amodu, Jamil Alexis, Aron Soleiman, Meredith Akerman, Poppy Addison, Toni Iurcotta, Horacio L Rodriguez Rilo
BACKGROUND: Pancreatectomies have been identified as procedures with an increased risk of readmission. In surgical patients, readmissions within 30 days of discharge are usually procedure-related. We sought to determine predictors of 30-day readmission following pancreatic resections in a large healthcare system. METHODS: We retrospectively collected information from the records of 383 patients who underwent pancreatic resections from 2004-2013. To find the predictors of readmission in the 30 days after discharge, we performed a univariate screen of possible variables using the Fisher's exact test for categorical variables and the Mann-Whitney U test for continuous variables...
April 22, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29675257/treatment-of-addison-s-disease-during-pregnancy
#9
Diana Oliveira, Adriana Lages, Sandra Paiva, Francisco Carrilho
Addison's disease, or primary adrenocortical insufficiency, is a long-term, potentially severe, rare endocrine disorder. In pregnancy, it is even rarer. We report the case of a 30-year-old pregnant patient with Addison's disease, referred to Obstetrics-Endocrinology specialty consult at 14 weeks gestation. She had been to the emergency department of her local hospital various times during the first trimester presenting with a clinical scenario suggestive of glucocorticoid under-replacement (nausea, persistent vomiting and hypotension), but this was interpreted as normal pregnancy symptoms...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29652241/bacterial-burden-in-critically-injured-ventilated-patients-does-not-correlate-with-progression-to-pneumonia
#10
Bradley M Dennis, Richard D Betzold, Daryl Patton, Herbert A Hopper, Judith Jenkins, Chris Fonnesbeck, Wonder Drake, Addison K May
BACKGROUND: Ventilator-associated pneumonia (VAP) is common in critically injured patients. The pathogenesis of VAP is not completely understood. We hypothesized that mechanically ventilated trauma patients who develop pneumonia have a progressive increase in pathogen burden over the course of ventilation until a threshold for symptomatic pneumonia is reached, leading to clinical suspicion of VAP. METHODS: Critically injured adults ventilated for more than two successive days were enrolled...
March 13, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29649425/effects-of-grape-consumption-on-biomarkers-of-inflammation-endothelial-function-and-pbmc-gene-expression-in-obese-subjects
#11
Allison S Bardagjy, Qian Hu, Kathryn A Giebler, Addison Ford, Francene M Steinberg
This study investigated effects of grape consumption on biomarkers of cardiovascular health in obese participants in both postprandial and chronic settings. Twenty obese adults participated in this randomized, placebo controlled, double-blinded crossover trial. Participants were randomized to consume 60 g freeze-dried polyphenol-rich whole grape powder (GP) or placebo (PBO) followed by high fat high carbohydrate (HFHC) meal challenge. Following acute challenge, participants consumed their respective treatment daily for 4 weeks to determine effects of chronic consumption...
April 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29622710/infectious-causes-of-addison-s-disease-1-organ-2-organisms
#12
Hafis Muhammed, Ram V Nampoothiri, Balan Louis Gaspar, Sanjay Jain
No abstract text is available yet for this article.
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29622661/isolation-of-a-multipotent-mesenchymal-stem-cell-like-population-from-human-adrenal-cortex
#13
Earn Gan, Wendy Robson, Peter Murphy, Robert Pickard, Simon Pearce, Rachel Oldershaw
BACKGROUND: The highly plastic nature of adrenal cortex suggests the presence of adrenocortical stem cells (ACSC) but the exact in vivo identity of ACSC remains elusive. A few studies have demonstrated the differentiation of adipose or bone marrow-derived mesenchymal stem cells (MSC) into steroid-producing cells. We therefore investigated the isolation of multipotent MSC from human adrenal cortex. METHODS: Human adrenals were obtained as discarded surgical material...
April 5, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29618662/human-mait-cells-exit-peripheral-tissues-and-recirculate-via-lymph-in-steady-state-conditions
#14
Valentin Voillet, Marcus Buggert, Chloe K Slichter, Julia D Berkson, Florian Mair, Mary M Addison, Yoav Dori, Gregory Nadolski, Maxim G Itkin, Raphael Gottardo, Michael R Betts, Martin Prlic
Mucosal-associated invariant T cells (MAIT cells) recognize bacterial metabolites as antigen and are found in blood and tissues, where they are poised to contribute to barrier immunity. Recent data demonstrate that MAIT cells located in mucosal barrier tissues are functionally distinct from their blood counterparts, but the relationship and circulation of MAIT cells between blood and different tissue compartments remains poorly understood. Previous studies raised the possibility that MAIT cells do not leave tissue and may either be retained or undergo apoptosis...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29611095/an-end-user-participatory-approach-to-collaboratively-refine-hiv-care-data-the-new-york-state-experience
#15
Carol-Ann Swain, Steven Sawicki, Diane Addison, Benjamin Katz, Kelly Piersanti, Abigail Baim-Lance, Daniel Gordon, Bridget J Anderson, Denis Nash, Clemens Steinbock, Bruce Agins
Existing data dissemination structures primarily rely on top-down approaches. Unless designed with the end user in mind, this may impair data-driven clinical improvements to Human Immunodeficiency Virus (HIV) prevention and care. In this study, we implemented a data visualization activity to create region-specific data presentations collaboratively with HIV providers, consumers of HIV care, and New York State (NYS) Department of Health AIDS Institute staff for use in local HIV care decision-making. Data from the NYS HIV Surveillance Registry (2009-2013) and HIV care facilities (2010-2015) participating in a Health Resources and Services Administration (HRSA) Systems Linkages and Access to Care project were used...
April 2, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29606394/computed-tomography-based-fat-and-muscle-characteristics-are-associated-with-mortality-after-transcatheter-aortic-valve-replacement
#16
Borek Foldyna, Fabian M Troschel, Daniel Addison, Florian J Fintelmann, Sammy Elmariah, Deborah Furman, Parastou Eslami, Brian Ghoshhajra, Michael T Lu, Venkatesh L Murthy, Udo Hoffmann, Ravi Shah
BACKGROUND: Computed tomography (CT)-based fat and muscle measures are associated with outcome in large populations. We tested if muscle and fat characteristics are associated with long-term outcomes after TAVR. METHODS: We included 403 clinical CTs performed prior to TAVR at our center between 2008 and 2016, measuring area (cm2 ) and density (Hounsfield units, HU) of both psoas muscles (PM), subcutaneous adipose (SAT), and visceral adipose tissue (VAT). Area measures were indexed to height, log-transformed and both area and density were standardized for analysis...
March 22, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29599540/society-is-ready-for-a-new-kind-of-science-is-academia
#17
Bonnie L Keeler, Rebecca Chaplin-Kramer, Anne D Guerry, Prue F E Addison, Charles Bettigole, Ingrid C Burke, Brad Gentry, Lauren Chambliss, Carrie Young, Alexander J Travis, Chris T Darimont, Doria R Gordon, Jessica Hellmann, Peter Kareiva, Steve Monfort, Lydia Olander, Tim Profeta, Hugh P Possingham, Carissa Slotterback, Eleanor Sterling, Tamara Ticktin, Bhaskar Vira
No abstract text is available yet for this article.
July 1, 2017: Bioscience
https://www.readbyqxmd.com/read/29594318/adrenal-crisis-after-first-infusion-of-zoledronic-acid-a-case-report
#18
M Smrecnik, Z Kavcic Trsinar, T Kocjan
Patients with Addison's disease are at greater risk of having reduced bone mineral density and hip fractures and are thus more likely to receive a bisphosphonate than their peers. Potent intravenous bisphosphonates could provoke an acute phase reaction. An 80-year-old female with Addison's disease received her first infusion of zoledronic acid for osteoporosis at our outpatient clinic around noon. Despite doubling her usual afternoon hydrocortisone dose, she became feverish, nauseous, extremely weak, and hypotensive over the night...
March 28, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29580220/pragmatic-randomised-controlled-trial-of-a-trauma-focused-guided-self-help-programme-versus-individual-trauma-focused-cognitive-behavioural-therapy-for-post-traumatic-stress-disorder-rapid-trial-protocol
#19
Claire Nollett, Catrin Lewis, Neil Kitchiner, Neil Roberts, Katy Addison, Lucy Brookes-Howell, Sarah Cosgrove, Katherine Cullen, Anke Ehlers, Sarah Heke, Mark Kelson, Karina Lovell, Kim Madden, Kirsten McEwan, Rachel McNamara, Ceri Phillips, Timothy Pickles, Natalie Simon, Jonathan Bisson
BACKGROUND: There is good evidence that trauma-focused therapies for Post-Traumatic Stress Disorder are effective. However, they are not always feasible to deliver due a shortage of trained therapists and demands on the patient. An online trauma-focused Guided Self-Help (GSH) programme which could overcome these barriers has shown promise in a pilot study. This study will be the first to evaluate GSH against standard face-to-face therapy to assess its suitability for use in the NHS. METHODS: The study is a large-scale multi-centre pragmatic randomised controlled non-inferiority trial, with assessors masked to treatment allocation...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29577381/remote-mentoring-of-point-of-care-ultrasound-skills-to-inexperienced-operators-using-multiple-telemedicine-platforms-is-a-cell-phone-good-enough
#20
Andrew Smith, Reuben Addison, Peter Rogers, Jordan Stone-McLean, Sarah Boyd, Kristopher Hoover, Megan Pollard, Adam Dubrowski, Mike Parsons
OBJECTIVES: Telemedicine technology contributes to the teaching of point-of-care ultrasound (US); however, expensive equipment can limit its deployment in resource-challenged settings. We assessed 3 low-cost telemedicine solutions capable of supporting remote US training to determine feasibility, acceptability, and effectiveness. We also explored the value of instructional videos immediately before telementoring. METHODS: Thirty-six participants were randomly assigned to receive US mentoring in 1 of 3 telemedicine conditions: multiple fixed cameras, a smartphone, and traditional audio with a live US stream...
March 25, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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