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https://www.readbyqxmd.com/read/28795340/vertebral-fractures-assessed-with-dual-energy-x-ray-absorptiometry-in-patients-with-addison-s-disease-on-glucocorticoid-and-mineralocorticoid-replacement-therapy
#1
Valentina Camozzi, Corrado Betterle, Anna Chiara Frigo, Veronica Zaccariotto, Martina Zaninotto, Erica De Caneva, Paola Lucato, Walter Gomiero, Silvia Garelli, Chiara Sabbadin, Monica Salvà, Miriam Dalla Costa, Marco Boscaro, Giovanni Luisetto
PURPOSE: to assess bone damage and metabolic abnormalities in patients with Addison's disease given replacement doses of glucocorticoids and mineralocorticoids. METHODS: A total of 87 patients and 81 age-matched and sex-matched healthy controls were studied. The following parameters were measured: urinary cortisol, serum calcium, phosphorus, creatinine, 24-h urinary calcium excretion, bone alkaline phosphatase, parathyroid hormone, serum CrossLaps, 25 hydroxyvitamin D, and 1,25 dihydroxyvitamin D...
August 9, 2017: Endocrine
https://www.readbyqxmd.com/read/28793997/effect-of-intensive-versus-standard-blood-pressure-treatment-according-to-baseline-prediabetes-status-a-post-hoc-analysis-of-a-randomized-trial
#2
Adam P Bress, Jordan B King, Kathryn E Kreider, Srinivasan Beddhu, Debra L Simmons, Alfred K Cheung, Yingying Zhang, Michael Doumas, John Nord, Mary Ellen Sweeney, Addison A Taylor, Charles Herring, William J Kostis, James Powell, Anjay Rastogi, Christianne L Roumie, Alan Wiggers, Jonathan S Williams, Reem Yunis, Athena Zias, Greg W Evans, Tom Greene, Michael V Rocco, William C Cushman, David M Reboussin, Mark N Feinglos, Vasilios Papademetriou
OBJECTIVE: To determine whether the effects of intensive (<120 mmHg) compared with standard (<140 mmHg) systolic blood pressure (SBP) treatment are different among those with prediabetes versus those with fasting normoglycemia at baseline in the Systolic Blood Pressure Intervention Trial (SPRINT). RESEARCH DESIGN AND METHODS: This was a post hoc analysis of SPRINT. SPRINT participants were categorized by prediabetes status, defined as baseline fasting serum glucose ≥100 mg/dL versus those with normoglycemia (fasting serum glucose <100 mg/dL)...
August 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28771928/catalytic-functionalization-of-styrenyl-epoxides-via-2-nickela-ii-oxetanes
#3
Addison N Desnoyer, Jialing Geng, Marcus W Drover, Brian O Patrick, Jennifer A Love
Low-valent nickel is shown to preferentially isomerize mono- or disubstituted epoxides into their corresponding aldehydes. Experiments with tetrasubstituted epoxides demonstrate that these reactions proceed via reactive 2-nickelaoxetane intermediates, and that the oxidative addition step likely occurs with retention of configuration. The monosubstituted aldehyde isomerization products were found to rapidly react with HBpin to form boronate esters. These hydroboration reactions could be performed catalytically...
August 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28765037/vitamin-d-effects-on-monocytes%C3%AC-ccl-2-il6-and-cd14-transcription-in-addison-s-disease-and-hla-susceptibility
#4
A U Kraus, M Penna-Martinez, G Meyer, K Badenhoop
Addisońs disease is a rare autoimmune disorder leading to adrenal insufficiency and life-long glucocorticoid dependency. Vitamin D receptor (VDR) polymorphisms and vitamin D deficiency predispose to Addisońs disease. Aim of the current study was, to investigate potential anti-inflammatory vitamin D effects on monocytes in Addisońs disease, focusing on inflammatory CCL-2 and IL6, as well on monocyte CD14 markers. Addisońs disease is genetically linked to distinct HLA susceptibility alleles. Therefore we analyzed, whether HLA genotypes differed for vitamin D effects on monocyte markers...
July 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28764794/exploration-of-knowledge-and-understanding-in-patients-with-primary-adrenal-insufficiency-a-mixed-methods-study
#5
L M Shepherd, A A Tahrani, C Inman, W Arlt, D M Carrick-Sen
BACKGROUND: Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose; failure to do so may lead to an adrenal crisis. The aim of the study was to explore patients PAI knowledge and understanding of the condition, steroid replacement adjustment during acute illness or stress and provided education. METHODS: Ten adult patients with PAI were purposefully recruited from two hospitals in a tertiary NHS Trust in England, UK...
August 1, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28758924/unusual-onset-of-celiac-disease-and-addison-s-disease-in-a-12-year-old-boy
#6
Francesco Miconi, Emanuela Savarese, Giovanni Miconi, Gabriele Cabiati, Valentina Rapaccini, Nicola Principi, Susanna Esposito
BACKGROUND: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. CASE PRESENTATION: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here...
July 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28748191/the-yin-and-yang-between-plasma-glucose-levels-and-cortisol-replacement-therapy-in-schmidt-s-syndrome
#7
Christopher A Newton, Eleni Sheehan, Kathleen Wyne, Kenneth Cusi, Julio Leey, Hans K Ghayee
Objective: To illustrate how steroid replacement in adrenal insufficiency can influence the development of hypoglycemia in a patient with type 1 diabetes mellitus (T1D). Methods: We describe the case of a 36-year-old female patient with T1D and Addison's disease (Schmidt's syndrome) on multiple daily insulin injections who presented with recurrent hypoglycemia despite being on physiological replacement doses of hydrocortisone. Results: With the assistance of continuous glucose monitoring technology, a pattern of nocturnal hypoglycemia was clearly identified...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28742782/in-response
#8
Sergio D Bergese, Michael L Mestek, Scott D Kelley, Robert McIntyre, Alberto A Uribe, Rakesh Sethi, James N Watson, Paul S Addison
No abstract text is available yet for this article.
July 21, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28741447/-express-single-nucleotide-polymorphism-in-the-col11a2-gene-associated-with-heat-pain-sensitivity-in-knee-osteoarthritis
#9
Kwo Wei David Ho, Margaret R Wallace, Kimberly T Sibille, Emily J Bartley, Yenisel Cruz-Almeida, Toni L Glover, Christopher D King, Burel R Goodin, Adriana Addison, Jeffrey C Edberg, Roland Staud, Laurence A Bradley, Roger B Fillingim
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28733292/natural-history-of-autoimmune-primary-ovarian-insufficiency-in-patients-with-addison-s-disease-from-normal-ovary-function-to-overt-ovary-dysfunction
#10
Annamaria De Bellis, Giuseppe Bellastella, Alberto Falorni, Ernesto Aitella, Mariluce Barrasso, Maria Ida Maiorino, Elio Bizzarro, Antonio Bellastella, Dario Giugliano, Katherine Esposito
CONTEXT: Women with autoimmune Addison's disease with normally ovulatory cycles but positive for steroid cells antibodies (StCA) have been considered at risk of premature ovarian insufficiency (POI). DESIGN: Thirty-three women younger than 40 years, with subclinical-clinical Addison's disease but with normally ovulatory menses, were followed-up for 10 years to evaluate the long-term time-related variations of StCA, ovarian function and follicular reserve. All patients and 27 control women were investigated at start and every year for the presence and titer of StCA (by indirect immunofluorescence), serum concentrations of anti-Mullerian hormone (AMH) and ovarian function along four consecutive menses every year...
July 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28729350/structures-of-the-crispr-genome-integration-complex
#11
Addison V Wright, Jun-Jie Liu, Gavin J Knott, Kevin W Doxzen, Eva Nogales, Jennifer A Doudna
CRISPR-Cas systems depend on the Cas1-Cas2 integrase to capture and integrate short foreign DNA fragments into the CRISPR locus, enabling adaptation to new viruses. We present crystal structures of Cas1-Cas2 bound to both donor and target DNA in intermediate and product integration complexes, as well as a cryo-electron microscopy structure of the full CRISPR locus integration complex including the accessory protein Integration Host Factor (IHF). The structures show unexpectedly that indirect sequence recognition dictates integration site selection by favoring deformation of the repeat and the flanking sequences...
July 20, 2017: Science
https://www.readbyqxmd.com/read/28717080/addison-s-disease-caused-by-tuberculosis-with-atypical-hyperpigmentation-and-active-pulmonary-tuberculosis
#12
Hiroki Namikawa, Yasuhiko Takemoto, Shigeto Kainuma, Sakurako Umeda, Ayako Makuuchi, Kazuo Fukumoto, Masanori Kobayashi, Shigeki Kinuhata, Yoshihiro Isaka, Hiromitsu Toyoda, Noriko Kamata, Yoshihiro Tochino, Yoshikazu Hiura, Mina Morimura, Taichi Shuto
We herein report a case of Addison's disease caused by tuberculosis characterized by atypical hyperpigmentation, noted as exacerbation of the pigmentation of freckles and the occurrence of new freckles, that was diagnosed in the presence of active pulmonary tuberculosis. The clinical condition of the patient was markedly ameliorated by the administration of hydrocortisone and anti-tuberculosis agents. When exacerbation of the pigmentation of the freckles and/or the occurrence of new freckles are noted, Addison's disease should be considered as part of the differential diagnosis...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28708663/in-response
#13
Sergio D Bergese, Michael L Mestek, Scott D Kelley, Robert McIntyre, Alberto A Uribe, Rakesh Sethi, James N Watson, Paul S Addison
No abstract text is available yet for this article.
July 13, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28693118/high-prevalence-of-organ-specific-autoantibodies-in-indian-type-1-diabetic-patients
#14
Shivaprasad Channabasappa, Anish Kolly, Annie Pulikkal, K M Prasanna Kumar
BACKGROUND: Type 1 diabetes (T1D) is frequently associated with other autoimmune conditions such as autoimmune thyroiditis, coeliac disease (CD) and Addison's disease. There are sparse data on the prevalence of antibodies against these conditions in Indian patients with T1D. This study aims to evaluate prevalence of these T1D associated autoantibodies in Indian patients. METHODS: Two hundred and fifty-eight patients with T1D were recruited from the Bangalore Diabetes Hospital and the Vydehi Institute of Medical Sciences and Research Centre (VIMS) for the study...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28691118/contrast-enhanced-ultrasound-reveals-exercise-induced-perfusion-deficits-in-claudicants
#15
Rishi Kundi, Steven J Prior, Odessa Addison, Michael Lu, Alice S Ryan, Brajesh K Lal
BACKGROUND: Contrast-Enhanced Ultrasonography (CEUS) is an imaging modality allowing perfusion quantification in targeted regions of interest of the lower extremity that has not been possible with color-flow imaging or with measurement of ankle brachial indices. We developed a protocol to quantify lower extremity muscle perfusion impairment in PAD patients in response to exercise. METHODS AND FINDINGS: Thirteen patients with Rutherford Class I-III Peripheral Arterial Disease (PAD) and no prior revascularization procedures were recruited from the Baltimore Veterans Affairs Medical Center and compared with eight control patients without PAD...
2017: J Vasc Endovasc Surg
https://www.readbyqxmd.com/read/28687693/adrenal-crisis-in-metastatic-breast-cancer
#16
Bernhard Doleschal, Andreas Petzer, Karl J Aichberger
A female patient with oestrogen receptor-positive and human epidermal growth factor receptor 2 (HER2)-positive invasive lobular breast cancer presented with progressive disease on CT scan. Some days after initiation of antineoplastic chemotherapy and anti-HER2 targeted antibody therapy, the patient presented with profuse diarrhoea, neutropaenia, nausea and weakness. Although Clostridium difficile was rapidly tackled as a causative agent of gastrointestinal complaints, clinical situation did not markedly improve despite proper antimicrobial treatment...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28683262/untangling-the-neural-circuits-for-sexual-behavior
#17
Jonathan Woodson, Addison Niemeyer, Joseph Bergan
In this issue, Ishii and colleagues identify an anatomically and genetically defined circuit by which a single compound, exocrine gland-secreted peptide-1 (ESP1), enhances reproductive behavior in female mice.
July 5, 2017: Neuron
https://www.readbyqxmd.com/read/28680774/diabetic-ketoacidosis-an-emergency-medicine-simulation-scenario
#18
Reuben Addison, Tate Skinner, Felix Zhou, Michael Parsons
Simulation provides a safe environment where learning is enhanced through the deliberate practice of skills and controlled management of a variety of clinical encounters. This is particularly important for core cases and low-frequency, high-stakes procedures and encounters. Competency-based medical education has seen widespread adoption in the field along with ongoing work in the areas of undergraduate and postgraduate training. Similarly, effective professional development activities stand to benefit greatly from a more stringent integration of simulation and competency-based approaches...
May 29, 2017: Curēus
https://www.readbyqxmd.com/read/28675047/-i-believe-high-blood-pressure-can-kill-me-using-the-pen-3-cultural-model-to-understand-patients-perceptions-of-an-intervention-to-control-hypertension-in-ghana
#19
Sarah Blackstone, Juliet Iwelunmor, Jacob Plange-Rhule, Joyce Gyamfi, Nana Kofi Quakyi, Micheal Ntim, Abigail Addison, Gbenga Ogedegbe
OBJECTIVES: Currently in Ghana, there is an on-going task-shifting strategy in which nurses are trained in hypertension management. While this study will provide useful information on the viability of this approach, it is not clear how patients in the intervention perceive hypertension, the task-shifting strategy, and its effects on blood pressure management. The objective of this paper is to examine patients' perceptions of hypertension and hypertension management in the context of an on-going task-shifting intervention to manage blood pressure control in Ghana...
July 4, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28672742/high-prevalence-of-organ-specific-autoantibodies-in-indian-type-1-diabetic-patients
#20
Channabasappa Shivaprasad, Anish Kolly, Annie Pulikkal, K M Prasanna Kumar
BACKGROUND: Type 1 diabetes (T1D) is frequently associated with other autoimmune conditions such as autoimmune thyroiditis, coeliac disease (CD) and Addison's disease. There are sparse data on the prevalence of antibodies against these conditions in Indian patients with T1D. This study aims to evaluate prevalence of these T1D associated autoantibodies in Indian patients. METHODS: Two hundred and fifty-eight patients with T1D were recruited from the Bangalore Diabetes Hospital and the Vydehi Institute of Medical Sciences and Research Centre (VIMS) for the study...
July 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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