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Chlamydia trachomatis

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https://www.readbyqxmd.com/read/28431099/effect-of-cold-water-induced-stress-on-immune-response-pathology-and-fertility-in-mice-during-chlamydia-muridarum-genital-infection
#1
Tesfaye Belay, Anthony Woart, Vincent Graffeo
Genital infection by Chlamydia trachomatis (CT) is the most common bacterial sexually-transmitted disease worldwide. It causes serious reproductive health complications, including pelvic inflammatory disease and infertility. Stress is implicated as a risk factor for various infections; however, its effect on chlamydia genital infection is unknown. We previously showed that repeated exposure of mice to cold water results in increased severity of chlamydia genital infection. In the present study, cold water-induced stress resulted in: i) elevated levels of NE and EP in the spleen and genital tract of stressed mice; ii) elevated IL-1β, TNF-α, IL-6 and NO production in macrophage-rich peritoneal cells of mice; iii) supplement of NE in vitro exerts an immunosuppressive effect on splenic T cell production of cytokines; iv) decreased C...
April 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28430679/cervicovaginal-levels-of-human-%C3%AE-defensin-1-2-3-and-4-of-reproductive-aged-women-with-chlamydia-trachomatis-infection
#2
Nathália Mayumi Noda-Nicolau, Larissa Brito Bastos, Aline Nascimento Bolpetti, Gabriel Vitor Silva Pinto, Larissa Doddi Marcolino, Camila Marconi, Carolina Sanitá Tafner Ferreira, Jossimara Polettini, Eliane Passarelli Vieira, Márcia Guimarães da Silva
OBJECTIVE: This study included women attending primary health care units in Botucatu, São Paulo, Brazil, to assess the cervicovaginal levels of human β-defensin (hBD) 1, 2, 3, and 4 during Chlamydia trachomatis infection. PATIENTS AND METHODS: Cervicovaginal samples were collected for Pap testing and assessing the presence of infection by C. trachomatis, human papillomavirus, Neisseria gonorrhoeae, and Trichomonas vaginalis. Vaginal smears were taken to evaluate local microbiota...
April 21, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#3
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28427377/a-comprehensive-overview-of-urogenital-anorectal-and-oropharyngeal-neisseria-gonorrhoeae-testing-and-diagnoses-among-different-sti-care-providers-a-cross-sectional-study
#4
Casper D J den Heijer, Christian J P A Hoebe, Geneviève A F S van Liere, Jan E A M van Bergen, Jochen W L Cals, Frans S Stals, Nicole H T M Dukers-Muijrers
BACKGROUND: Gonorrhoea, caused by Neisseria gonorrhoeae (NG), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of NG test practice. In this study we wanted to compare NG diagnostic testing procedures between different STI care providers serving a defined geographic Dutch region (280,000 inhabitants). METHODS: Data on laboratory testing and diagnosis of urogenital and extragenital (i...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28425301/development-of-a-novel-rationally-designed-antibiotic-to-inhibit-a-nontraditional-bacterial-target
#5
Pavel Dibrov, Elena Dibrov, Thane G Maddaford, Melissa Kenneth, Jordan Nelson, Craig Resch, Grant N Pierce
The search for new nontraditional targets is a high priority in antibiotic design today. Bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. The present work identifies the Na(+)-translocating NADH:ubiquinone oxidoreductase (Na(+)-NQR), a key respiratory enzyme in many microbial pathogens, as indispensible for the Chlamydia trachomatis infectious process. Infection by Chlamydia trachomatis significantly increased first H(+) and then Na(+) levels within the host mammalian cell...
April 20, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28421619/molecular-detection-of-chlamydia-trachomatis-and-semen-quality-of-sexual-partners-of-infertile-women
#6
M López-Hurtado, M Velazco-Fernández, M J E Pedraza-Sánchez, V R Flores-Salazar, R Villagrana Zesati, F M Guerra-Infante
Chlamydia trachomatis is considered as the bacterium that is more sexually transmitted as cause of male urethritis, epididymitis, orchitis and infertility. A total of 116 semen samples of men whose couples are infertile women were analysed. The quality of the semen was measured by standard procedures recommended by WHO while C. trachomatis was detected by the PCR assay. Thirty-seven semen samples were positive for C. trachomatis (31.9%). Regarding semen analysis, no different values were observed between positive and negative samples to C...
April 19, 2017: Andrologia
https://www.readbyqxmd.com/read/28413202/conventional-versus-molecular-detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-among-males-in-a-sexually-transmitted-infections-clinic
#7
S F Situ, C H Ding, S Nawi, A Johar, R Ramli
BACKGROUND: Chlamydia trachomatis and Neisseria gonorrhoeae are important bacterial pathogens of sexually transmitted infections (STIs) worldwide. This study sought to compare the analytical sensitivity and specificity of conventional methods against a rapid molecular method in detecting STIs caused by these bacteria. METHODS: Ninety five first-time male attendees of the Genito-urinary Medicine Clinic in Hospital Kuala Lumpur were included in this cross-sectional study...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413133/vaccination-with-the-polymorphic-membrane-protein-a-reduces-chlamydia-muridarum-induced-genital-tract-pathology
#8
Tina Müller, Elisabeth Becker, Sonja Stallmann, Anna Waldhuber, Franziska Römmler-Dreher, Simone Albrecht, Fabian Mohr, Johannes H Hegemann, Thomas Miethke
Chlamydia trachomatis serovars D-K are one of the most frequent causes of sexually transmitted infections of the female genital tract, with possible complications such as hydrosalpinx, pelvic inflammatory disease, extra-uterine gravidity or infertility. We used the murine genital tract infection model with C. muridarum for vaccination studies and found that more than 70% of the infected mice suffered from uterus dilatations and/or hydrosalpinx. Systemic consequences of the vaginal infection were apparent by splenomegaly ten to fifteen days post infection...
April 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28407642/the-case-for-extragenital-screening-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-the-college-health-setting
#9
Lauren N Drinkard, Rebecca A Huxta, Ashlee Halbritter, Giang T Nguyen, David Malebranche
BACKGROUND: Although the Centers for Disease Control and Prevention does not recommend routine oropharyngeal and anorectal screening for Chlamydia trachomatis and Neisseria gonorrhoeae in the general population, they do recommend it for men who have sex with men. However, risk-based extragenital screening of men may not have been adopted at all college health centers, and existing research has not focused on the college population. METHODS: We examined health records of men at a college health center in a large urban university over 6 years to evaluate effectiveness of C...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28406272/dorsal-longitudinal-foreskin-cut-is-associated-with-reduced-risk-of-hiv-syphilis-and-genital-herpes-in-men-a-cross-sectional-study-in-papua-new-guinea
#10
Andrew J Vallely, David MacLaren, Matthew David, Pamela Toliman, Angela Kelly-Hanku, Ben Toto, Rachael Tommbe, Zure Kombati, Petronia Kaima, Kelwyn Browne, Clement Manineng, Lalen Simeon, Claire Ryan, Handan Wand, Peter Hill, Greg Law, Peter M Siba, W John H McBride, John M Kaldor
INTRODUCTION: Various forms of penile foreskin cutting are practised in Papua New Guinea. In the context of an ecological association observed between HIV infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level. METHODS: We conducted a cross-sectional study among men attending voluntary confidential HIV counselling and testing clinics. Following informed consent, participants had a face-to-face interview and an examination to categorize foreskin status...
April 3, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28404675/nucleic-acid-extraction-from-residual-aptima-clinical-samples-evaluation-of-automated-platform-to-enhance-workflow
#11
Julia Mayes, Nadika Liyanarachchy, Michelle N D Balm
Transcription mediated amplification with the Aptima Combo 2 (AC2) assay (Hologic) is a highly sensitive and specific method for detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) from clinical samples collected in Aptima collection systems (1).….
April 12, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28402260/dna-plasmid-vaccine-carrying-chlamydia-trachomatis-ct-major-outer-membrane-and-human-papillomavirus-16l2-proteins-for-anti-ct-infection
#12
Ledan Wang, Yiqi Cai, Yirong Xiong, Wangqi Du, Danwei Cen, Chanqiong Zhang, Yiling Song, Shanli Zhu, Xiangyang Xue, Lifang Zhang
Chlamydia trachomatis (Ct) is one of the most frequently encountered sexual infection all over the world, yielding tremendous reproductive problems (e.g. infertility and ectopic pregnancy) in the women. This work described the design of a plasmid vaccine that protect mice from Ct infection, and reduce productive tract damage by generating effective antibody and cytotoxic T cell immunity. The vaccine, s was composed of MOMP multi-epitope and HPV16L2 genes carried in pcDNA plasmid (i.e. pcDNA3.1/MOMP/HPV16L)...
March 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399813/the-netherlands-chlamydia-cohort-study-neccst-protocol-to-assess-the-risk-of-late-complications-following-chlamydia-trachomatis-infection-in-women
#13
B M Hoenderboom, A A M van Oeffelen, B H B van Benthem, J E A M van Bergen, N H T M Dukers-Muijrers, H M Götz, C J P A Hoebe, A A Hogewoning, F R M van der Klis, D van Baarle, J A Land, M A B van der Sande, M G van Veen, F de Vries, S A Morré, I V F van den Broek
BACKGROUND: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI) among young women, can result in serious sequelae. Although the course of infection is often asymptomatic, CT may cause pelvic inflammatory disease (PID), leading to severe complications, such as prolonged time to pregnancy, ectopic pregnancy, and tubal factor subfertility. The risk of and risk factors for complications following CT-infection have not been assessed in a long-term prospective cohort study, the preferred design to define infections and complications adequately...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28399798/the-picasso-cohort-baseline-characteristics-of-a-cohort-of-men-who-have-sex-with-men-and-male-to-female-transgender-women-at-high-risk-for-syphilis-infection-in-lima-peru
#14
Noah Kojima, Hayoung Park, Kelika A Konda, Dvora L Joseph Davey, Claire C Bristow, Brandon Brown, Segundo R Leon, Silver K Vargas, Gino M Calvo, Carlos F Caceres, Jeffrey D Klausner
BACKGROUND: Men who have sex with men (MSM) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in Peru. METHODS: From 2013 to 2014, MSM and transwomen seeking human immunodeficiency virus (HIV) or sexually transmitted infection (STI) testing and/or treatment were recruited into a 2-year observational cohort study to determine predictors of recently acquired syphilis infection (defined as a rapid plasma reagin [RPR] titer ≥1:16 and a reactive treponemal antibody test) in Lima, Peru...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28398639/maternal-antibodies-to-chlamydia-trachomatis-and-risk-of-gastroschisis
#15
Samantha E Parker, Martha M Werler, Mika Gissler, Heljä-Marja Surcel
BACKGROUND: Gastroschisis, a birth defect of the abdominal wall, is increasing in prevalence. The largest increase in prevalence has been observed among young mothers (<20 years). The prevalence of Chlamydia trachomatis (CT) infection is highest among young women and has also been increasing over time. The objective was to investigate the association between immunoglobulin G antibodies to Chlamydia trachomatis (CT) (anti-CT) and Chlamydial heat shock protein 60 (anti-CHP60) during pregnancy, and risk of gastroschisis among offspring...
February 24, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28396556/pregnancy-outcomes-in-association-with-stds-including-genital-hsv-2-shedding-in-a-south-african-cohort-study
#16
Dhayendre Moodley, Benn Sartorius, Savithree Madurai, Vani Chetty, Suzanne Maman
OBJECTIVES: Genital herpes simplex virus-2 (HSV-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes. METHODS: In this retrospective observational study, we included a subgroup of pregnant women who were enrolled in a randomized control behavioural intervention study that was conducted in South Africa in 2008-2010. In pregnancy, women had a HIV rapid test done and a genital swab taken to test for curable STIs and HSV-2 DNA...
April 10, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28396349/biochemical-and-genetic-analysis-of-the-chlamydia-groel-chaperonins
#17
Melissa Illingworth, Anna J Hooppaw, Lu Ruan, Derek J Fisher, Lingling Chen
Chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. The paradigm Escherichia coli chaperonin, EcGroEL, and its cochaperonin, EcGroES, assist folding of proteins via an ATP-dependent mechanism. In addition to the presence of groEL and groES homologs, groEL paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. Chlamydia spp., which are obligate intracellular bacteria, have reduced genomes that nonetheless encode three groEL genes, ChgroEL, ChgroEL2 and ChgroEL3 We hypothesized that ChGroEL is the bona-fide chaperonin, while the paralogs perform novel, Chlamydia-specific functions...
April 10, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28388469/higher-prevalence-of-colonization-with-gardnerella-vaginalis-and-gram-negative-anaerobes-in-patients-with-recurrent-miscarriage-and-elevated-peripheral-natural-killer-cells
#18
R J Kuon, R Togawa, K Vomstein, M Weber, T Goeggl, T Strowitzki, U R Markert, S Zimmermann, V Daniel, A H Dalpke, B Toth
The role of vaginal infections in recurrent miscarriage (RM) is discussed controversially and screening is not recommended in international guidelines. Peripheral and uterine NK cells (pNK, uNK) play an important role in the establishment of a healthy pregnancy and are targets of immune diagnostics in RM patients. The aim of this study was to analyze the composition of the vaginal microbiota in RM patients and to correlate the findings to clinical characteristics as well as NK cell parameters. In total, n=243 RM patients with ≥3 consecutive miscarriages were recruited between 11/2011 and 03/2016...
March 30, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28385608/comparison-of-the-nine-polymorphic-membrane-proteins-of-chlamydia-trachomatis-for-their-ability-to-induce-protective-immune-responses-in-mice-against-a-c-muridarum-challenge
#19
Sukumar Pal, Alison Favaroni, Delia F Tifrea, Philipp T Hanisch, Sören E T Luczak, Johannes H Hegemann, Luis M de la Maza
OBJECTIVES: To test vaccines, formulated with novel antigens, to protect mice against Chlamydia infections. METHODS: To determine the ability of polymorphic membrane proteins (Pmps) to induce cross-species protective immune responses, recombinant fragments from all nine C. trachomatis serovar E Pmps were used to vaccinate BALB/c mice utilizing CpG-1826 and Montanide ISA 720 as adjuvants. C. muridarum recombinant MOMP and PBS, formulated with the same adjuvants, were used as positive and negative controls, respectively...
April 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28384432/utility-of-risk-based-chlamydia-testing-in-primary-care-analysis-of-retrospective-surveillance-data-among-women-in-melbourne-australia
#20
Anna L Wilkinson, Kathleen McNamee, Carol El-Hayek, Eric P F Chow, Catriona S Bradshaw, Norm Roth, B K Tee, Mark Stoové, Margaret Hellard
Background: Chlamydia (Chlamydia trachomatis) continues to be a public health challenge in Australia, with some contention as to the best screening approach. In the present study we examined chlamydia testing, positivity and sexual behaviour among women with the aim of informing targeted testing among women aged ≥30 years. Methods: A longitudinal analysis was conducted on retrospective surveillance data collected among women attending general practice, family planning and sexual health clinics participating in sentinel surveillance in Melbourne, Australia...
April 7, 2017: Sexual Health
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