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Chlamydia trachomatis

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https://www.readbyqxmd.com/read/28214469/cost-benefit-analysis-of-chlamydia-trachomatis-screening-in-pregnant-women-in-a-high-burden-setting-in-the-united-states
#1
Jared Ditkowsky, Khushal H Shah, Margaret R Hammerschlag, Stephan Kohlhoff, Tamar A Smith-Norowitz
BACKGROUND: Chlamydia trachomatis is the most common bacterial sexually transmitted infection (STI) in the United States (U.S.) [1] and remains a major public health problem. We determined the cost- benefit of screening all pregnant women aged 15-24 for Chlamydia trachomatis infection compared with no screening. METHODS: We developed a decision analysis model to estimate costs and health-related effects of screening pregnant women for C. trachomatis in a high burden setting (Brooklyn, NY)...
February 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28214223/evaluation-of-a-field-test-for-antibodies-against-chlamydia-trachomatis-during-trachoma-surveillance-in-nepal
#2
Michelle J Sun, Andrea I Zambrano, Laura Dize, Beatriz Munoz, Sarah Gwyn, Sailesh Mishra, Diana L Martin, Shekhar Sharma, Sheila K West
PURPOSE: Testing for antibodies to Chlamydia trachomatis has potential as a surveillance tool. Our evaluation compares lateral flow assays (LFAs) during surveillance surveys in Nepal with Multiplex bead array (MBA). Fifty children were randomly sampled from each of 15 random clusters in two districts of Nepal. Finger prick blood samples were collected from 1509 children and tested onsite for anti-Pgp3 antibodies by LFA. The LFA was read at 30min as negative, positive, or invalid. Tests results were also rated as difficult to read ("equivocal")...
January 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28205505/establishment-of-a-voluntary-electronic-chlamydia-trachomatis-laboratory-surveillance-system-in-germany-2008-to-2014
#3
Sandra Dudareva-Vizule, Karin Haar, Andrea Sailer, Klaus Jansen, Osamah Hamouda, Hilmar Wisplinghoff, Carsten Tiemann, Eberhard Pape, Viviane Bremer
Chlamydia trachomatis (CT) infections are not reportable in Germany and limited data on prevalence are available. CT screening has been offered free of charge to pregnant women since 1995 and to all women under 25 years since 2008. For symptomatic women and men, diagnostic testing is covered by statutory health insurance. We describe the establishment of a nationwide, laboratory-based, voluntary sentinel that electronically collects information on all performed CT tests with test results, test reason and patient information...
February 9, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28201690/sensing-the-enemy-containing-the-threat-cell-autonomous-immunity-to-chlamydia-trachomatis
#4
Ryan Finethy, Jörn Coers
No abstract text is available yet for this article.
November 1, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28199392/comparison-of-the-population-excess-fraction-of-chlamydia-trachomatis-infection-on-pelvic-inflammatory-disease-at-12-months-in-the-presence-and-absence-of-chlamydia-testing-and-treatment-systematic-review-and-retrospective-cohort-analysis
#5
Bethan Davies, Katy M E Turner, Stella Leung, B Nancy Yu, Maria Frølund, Thomas Benfield, James Blanchard, Henrik Westh, Helen Ward
BACKGROUND: The impact of Chlamydia trachomatis (chlamydia) control on the incidence of pelvic inflammatory disease (PID) is theoretically limited by the proportion of PID caused by chlamydia. We estimate the population excess fraction (PEF) of treated chlamydia infection on PID at 12-months in settings with widespread chlamydia control (testing and treatment) and compare this to the estimated PEF of untreated chlamydia. METHODS: We used two large retrospective population-based cohorts of women of reproductive age from settings with widespread chlamydia control to calculate the PEF of treated chlamydia on PID at 12-months...
2017: PloS One
https://www.readbyqxmd.com/read/28184217/chlamydial-lipoproteins-stimulate-toll-like-receptors-1-2-mediated-inflammatory-responses-through-myd88-dependent-pathway
#6
Yong Wang, Qiong Liu, Ding Chen, Jie Guan, Linghui Ma, Guangming Zhong, Hengping Shu, Xiang Wu
Chlamydiae are very important pathogens which could cause several types of diseases in human, but little is known about its pathogenic mechanism. In order to elucidate host inflammatory response and the signal pathway induced by Chlamydial lipoproteins, the predicted lipoproteins of Chlamydia trachomatis were tested for their ability to induce the release of proinflammatory cytokines by mouse macrophages or human TLR (Toll-Like Receptor) expressing cell lines. The results showed that recombinant proteins of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28182670/killing-of-diverse-eye-pathogens-acanthamoeba-spp-fusarium-solani-and-chlamydia-trachomatis-with-alcohols
#7
Yousuf Aqeel, Raquel Rodriguez, Aparajita Chatterjee, Robin R Ingalls, John Samuelson
BACKGROUND: Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), a fungus (Fusarium solani), and a bacterium (Chlamydia trachomatis). Hand-eye contact is likely a contributor to the spread of these pathogens, and so hand washing with soap and water or alcohol-based hand sanitizers (when water is not available) might reduce their transmission. Recently we showed that ethanol and isopropanol in concentrations present in hand sanitizers kill walled cysts of Giardia and Entamoeba, causes of diarrhea and dysentery, respectively...
February 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28182591/comparison-of-cobas-4800-m2000-viper-xtr-and-infinity-80-automated-instruments-when-processing-urine-specimens-for-the-diagnosis-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae
#8
Max A Chernesky, Dan Jang, Jodi Gilchrist, Marek Smieja, Manuel Arias, Todd Hatchette, Andre Poirier, Donna Mayne, Sam Ratnam
OBJECTIVES: North American and European advisory groups recommend testing for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) with nucleic acid amplification tests. Testing is often performed on automated instruments. The objectives of this study were to process urines for the diagnosis of CT and NG and to examine workflow procedures and outcomes. METHODS: While processing 1, 24, 48, 96, and 192 urine specimens on 3 batch-mode systems which use 96-well plates: cobas 4800, m2000, and Viper XTR and the random access cartridge testing GeneXpert Infinity 80, we measured assay performance, hands-on time for processing and maintenance, reagents and plastics consumption, time required to obtain results, and testing accuracy...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28178111/demographics-behaviors-and-sexual-health-characteristics-of-high-risk-men-who-have-sex-with-men-and-transgender-women-who-use-social-media-to-meet-sex-partners-in-lima-peru
#9
Jeremy Y Chow, Kelika A Konda, Gino M Calvo, Jeffrey D Klausner, Carlos F Cáceres
BACKGROUND: Men who have sex with men (MSM) and transgender women (TW) in Peru bear a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). In a context of quickly expanding communication technology, increasing numbers of MSM and TW are using social media applications to seek sex partners. Understanding social media users and their sex partnering practices is needed to update HIV and STI prevention programming. METHODS: In Lima, Peru, 312 MSM and 89 TW from 2 STI clinics underwent HIV and STI testing and participated in a survey of demographics, behaviors, sexual health, and social media practices...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28175294/mirnas-that-associate-with-conjunctival-inflammation-and-ocular-chlamydia-trachomatis-infection-do-not-predict-progressive-disease
#10
Tamsyn Derrick, Athumani M Ramadhani, Karim Mtengai, Patrick Massae, Matthew J Burton, Martin J Holland
No abstract text is available yet for this article.
February 8, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28167140/a-review-of-expedited-partner-therapy-for-the-management-of-sexually-transmitted-infections-in-adolescents
#11
REVIEW
Kathryn E Gannon-Loew, Cynthia Holland-Hall, Andrea E Bonny
INTRODUCTION: Adolescents are at high risk for acquiring and becoming re-infected with sexually transmitted infections (STIs). Partner notification and treatment are essential to preventing the spread of STIs. Expedited partner therapy (EPT) is a method of partner treatment utilized by medical providers to treat patients' sexual partners without direct medical evaluation or counseling. OBJECTIVE: The objective of this article is to review the current literature regarding EPT effectiveness, patients' attitudes and acceptance of EPT, and providers' views and practices surrounding the use of this method of partner treatment...
February 3, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28166698/partner-notification-and-treatment-for-sexually-transmitted-infections-among-pregnant-women-in-gaborone-botswana
#12
Ogechukwu A Offorjebe, Adriane Wynn, Neo Moshashane, Dvora Joseph Davey, Kaitlin Arena, Doreen Ramogola-Masire, Ponatshego Gaolebale, Chelsea Morroni, Jeffrey D Klausner
Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) are sexually transmitted infections (STIs) associated with adverse birth outcomes. Untreated partners contribute to high rates of STI reinfection; thus, partner notification and treatment remain important components of STI care and control. A prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana who enrolled in an STI screening study...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28159916/impact-of-deploying-multiple-point-of-care-tests-with-a-sample-first-approach-on-a-sexual-health-clinical-care-pathway-a-service-evaluation
#13
Emma M Harding-Esch, Achyuta V Nori, Aseel Hegazi, Marcus J Pond, Olanike Okolo, Anthony Nardone, Catherine M Lowndes, Phillip Hay, S Tariq Sadiq
OBJECTIVES: To assess clinical service value of STI point-of-care test (POCT) use in a 'sample first' clinical pathway (patients providing samples on arrival at clinic, before clinician consultation). Specific outcomes were: patient acceptability; whether a rapid nucleic acid amplification test (NAAT) for Chlamydia trachomatis/Neisseria gonorrhoeae (CT/NG) could be used as a POCT in practice; feasibility of non-NAAT POCT implementation for Trichomonas vaginalis (TV) and bacterial vaginosis (BV); impact on patient diagnosis and treatment...
February 3, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28152632/cervical-fluid-calreticulin-and-cathepsin-g-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#14
Ctirad Andrys, Ivana Musilova, Marcela Drahosova, Ondrej Soucek, Lenka Pliskova, Bo Jacobsson, Nanbert Zhong, Marian Kacerovsky
OBJECTIVE: The study aimed to determine the cervical calreticulin and cathepsin-G concentrations in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI). METHODS: Eighty women with singleton pregnancies complicated by PPROM were included in this study. Cervical and amniotic fluids were obtained at the time of admission, and concentrations of calreticulin and cathepsin-G in cervical fluid were determined using ELISA...
February 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28146186/-the-current-prevalence-of-chlamydia-trachomatis-infection-among-teenagers-and-young-asymptomatic-chilean-women-justifies-the-periodic-surveillance
#15
Milena Zamboni, Constanza Ralph, Patricia García, Mauricio Cuello
INTRODUCTION: Chlamydia trachomatis infection constitutes the most common sexual transmitted disease (STD) among young women. International studies demonstrate that prevalence changes over time and also according to places. AIMS: To estimate the prevalence of this infection among asymptomatic Chilean women (15 to 24 years old) and correlating with risk factor occurrence. METHODS: Transversal cohort study to identify C. trachomatis infection through a diagnostic kit designed to detect and amplify cryptic plasmid DNA by quantitative PCR from endocervical sample...
December 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28141509/development-validation-and-testing-costs-of-an-in-house-real-time-polymerase-chain-reaction-assay-for-the-detection-of-chlamydia-trachomatis
#16
Camila Gurgel Dos Santos, Meritxell Sabidó, André Luiz Leturiondo, Cynthia de Oliveira Ferreira, Thielle Pereira da Cruz, Adele Schwartz Benzaken
To improve screening of Chlamydia trachomatis (CT) in Brazil, an accurate and affordable method is needed. The objective of this study was to develop and assess the performance and costs of a new in-house real time polymerase chain reaction (qPCR) assay for the diagnosis of CT infection. Asymptomatic women aged 14-25 years who attended primary health services in Manaus, Brazil, were screened for CT using the Digene® Hybrid Capture II (HCII CT-ID) CT-ID DNA-test. A subset of cervical specimens were tested using an in-house qPCR and a commercial qPCR (Artus qPCR) as a reference test...
January 27, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28140605/rates-of-chlamydia-trachomatis-infections-across-the-deployment-cycle-active-component-u-s-armed-forces-2008-2015
#17
Shauna Stahlman, Eric C Garges, Saixia Ying, Leslie L Clark
High rates of sexually transmitted infections (STIs), including Chlamydia trachomatis (CT), have been documented among U.S. military service members. However, it is unknown whether phases of the deployment cycle affect risk for CT. This article characterizes the rates of CT infections during the predeployment, deployment, and post-deployment phases for active component members of the U.S. Army, Navy, Air Force, and Marine Corps during 2008-2015. Cases of CT were defined using laboratory, reportable medical event, and prescription data in a sensitivity analysis approach...
January 2017: MSMR
https://www.readbyqxmd.com/read/28134005/chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-screening-and-treatment-of-pregnant-women-in-port-au-prince-haiti
#18
Claire C Bristow, Patricia Mathelier, Oksana Ocheretina, Daphne Benoit, Jean W Pape, Adriane Wynn, Jeffrey D Klausner
In Haiti, routine screening for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) among pregnant women is not conducted; yet these sexually transmitted infections (STIs) are associated with adverse birth and newborn health outcomes. We aimed to assess the acceptability and feasibility of screening and the prevalence of STIs among pregnant women in Port-au-Prince, Haiti. Pregnant women of at least 18 years of age who attend Haitian Study Group for Kaposi's sarcoma and Opportunistic Infections (GHESKIO) clinics in Port-au-Prince, Haiti provided self-collected vaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28129372/costing-of-national-sti-program-implementation-for-the-global-sti-control-strategy-for-the-health-sector-2016-2021
#19
Eline L Korenromp, Teodora Wi, Stephen Resch, John Stover, Nathalie Broutet
INTRODUCTION: In 2016 the World Health Assembly adopted the global strategy on Sexually Transmitted Infections (STI) 2016-2021 aiming to reduce curable STIs by 90% by 2030. We costed scaling-up priority interventions to coverage targets. METHODS: Strategy-targeted declines in Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum and Trichomonas vaginalis were applied to WHO-estimated regional burdens at 2012. Syndromic case management was costed for these curable STIs, symptomatic Herpes Simplex Virus 2 (HSV-2), and non-STI vaginal syndromes, with incrementally expanding etiologic diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28129328/chlamydia-trachomatis-pgp3-antibody-population-seroprevalence-before-and-during-an-era-of-widespread-opportunistic-chlamydia-screening-in-england-1994-2012
#20
Sarah C Woodhall, Gillian S Wills, Patrick J Horner, Rachel Craig, Jennifer S Mindell, Gary Murphy, Myra O McClure, Kate Soldan, Anthony Nardone, Anne M Johnson
BACKGROUND: Opportunistic chlamydia screening of <25 year-olds was nationally-implemented in England in 2008 but its impact on chlamydia transmission is poorly understood. We undertook a population-based seroprevalence study to explore the impact of screening on cumulative incidence of chlamydia, as measured by C.trachomatis-specific antibody. METHODS: Anonymised sera from participants in the nationally-representative Health Surveys for England (HSE) were tested for C...
2017: PloS One
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