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Chlamydia trachomatis

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https://www.readbyqxmd.com/read/29790947/antibodies-against-chlamydia-trachomatis-and-ovarian-cancer-risk-in-two-independent-populations
#1
Britton Trabert, Tim Waterboer, Annika Idahl, Nicole Brenner, Louise A Brinton, Julia Butt, Sally B Coburn, Patricia Hartge, Katrin Hufnagel, Federica Inturrisi, Jolanta Lissowska, Alexander Mentzer, Beata Peplonska, Mark E Sherman, Gillian S Wills, Sarah C Woodhall, Michael Pawlita, Nicolas Wentzensen
Background: Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations. Methods: Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects)...
May 21, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29782296/sexual-behaviors-attitudes-and-knowledge-about-sexually-transmitted-infections-a-cross-sectional-study-in-romania
#2
Alecsandra Iulia Grad, Simona Corina Senilă, Rodica Cosgarea, Alexandru Dumitru Tataru, Stefan Cristian Vesa, Mihaela Laura Vica, Horea Vladi Matei, Loredana Ungureanu
Sexually transmitted infections (STIs) are serious public health problems. Little is known about sex knowledge, attitudes, and sexual behaviors among young adults in Romania; an effective preventive campaigns should be based on an appropriate understanding of these factors. The aim of the present study was to obtain data about sexual behavior, attitudes, and knowledge about STIs among university students aged 18-25 in Romania. 3872 persons completed an internet-based questionnaire, advertised on Facebook, regarding sexual behavior, attitudes, and knowledge about STIs from January 28 to February 28, 2016...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782292/evaluation-of-symptomatic-patients-with-resistant-discharge
#3
Cemile Sonmez, Selma Usluca, Ismail Hakki Usluca, Irem Kalipci, Figen Sezen, Cemal Resat Atalay, Selcuk Kilic
The aim of this study was to detect the presence of Chlamydia trachomatis, Neisseria (N.) gonorrhoeae, Mycoplasma (M.) hominis, M. genitalium, Ureaplasma (U.) urealyticum, and Trichomonas (T.) vaginalis in patients with resistant discharge. The study also evaluated the concordance of the diagnostic tests. Samples from 156 patients were tested by direct microscopy and culture for T. vaginalis and Mycoplasma IES for M. hominis and U. urealyticum. Multiplex Polymerase Chain Reaction (PCR) was used to determine the presence of six agents...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29777489/serum-antibody-response-to-chlamydia-trachomatis-troa-and-htra-in-women-with-tubal-factor-infertility
#4
T Rantsi, P Joki-Korpela, K Hokynar, I Kalliala, H Öhman, H-M Surcel, J Paavonen, A Tiitinen, M Puolakkainen
Persistent genital chlamydial infection may lead to tubal factor infertility (TFI). Chlamydia trachomatis TroA and HtrA are proteins expressed during persistent chlamydial infection in vitro. We studied serum IgG antibody response against these proteins by EIA in women with TFI and in subfertile women without tubal pathology. Altogether, 22 of 258 subfertile women (8.5%) had TFI which was unilateral in 17 cases and bilateral in 5 cases. Overall, 55 (21.3%) of the 258 women had TroA and 39 (15.1%) had HtrA antibodies...
May 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29771869/performance-of-the-atlas-rapid-test-for-chlamydia-trachomatis-and-women-s-attitudes-toward-point-of-care-testing
#5
Lea E Widdice, Yu-Hsiang Hsieh, Barbara Silver, Mathilda Barnes, Perry Barnes, Charlotte A Gaydos
PURPOSE: This study compared performance of Atlas io® diagnostic platform, a point-of-care (POC) PCR assay for Chlamydia trachomatis (CT), to Aptima Combo 2, a standard of care laboratory-based nucleic acid amplification assay (NAAT), and evaluated patient attitudes toward POC testing. METHODS: Women ≥14 years undergoing CT screening/testing were recruited from an urban adolescent primary care practice (Teen Health Center, THC) and a sexually transmitted disease (STD) clinic...
May 1, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29770100/lymphogranuloma-venereum-in-quebec-re-emergence-among-men-who-have-sex-with-men
#6
C A Boutin, S Venne, M Fiset, C Fortin, D Murphy, A Severini, C Martineau, J Longtin, A C Labbé
Background: Lymphogranuloma venereum (LGV) is a sexually transmitted infection (STI) caused by Chlamydia trachomatis genotypes L1 , L2 and L3 . This LGV is associated with significant morbidity and increased risk of HIV transmission. While fewer than two cases per year were reported in Quebec before 2005, LGV emerged in 2005-2006 with 69 cases, followed by a period of low incidence (2007-2012), and subsequent re-emergence since 2013. Objectives: To describe the incidence of LGV in Quebec and the characteristics of the affected population, including demographics and risk factors, clinical manifestations, laboratory tests, treatments and reinfection rates...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29760479/immunoprofiling-of-chlamydia-trachomatis-using-whole-proteome-microarrays-generated-by-on-chip-in-situ-expression
#7
Katrin Hufnagel, Smiths Lueong, Martina Willhauck-Fleckenstein, Agnes Hotz-Wagenblatt, Beiping Miao, Andrea Bauer, Angelika Michel, Julia Butt, Michael Pawlita, Jörg D Hoheisel, Tim Waterboer
Using Chlamydia trachomatis (Ct) as a complex model organism, we describe a method to generate bacterial whole-proteome microarrays using cell-free, on-chip protein expression. Expression constructs were generated by two successive PCRs directly from bacterial genomic DNA. Bacterial proteins expressed on microarrays display antigenic epitopes, thereby providing an efficient method for immunoprofiling of patients and allowing de novo identification of disease-related serum antibodies. Through comparison of antibody reactivity patterns, we newly identified antigens recognized by known Ct-seropositive samples, and antigens reacting only with samples from cervical cancer (CxCa) patients...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29749879/lymphogranuloma-venereum-a-rare-and-forgotten-cause-of-rectal-stricture-formation
#8
Leia Craxford, Ashini Fox
Lymphogranuloma venereum (LGV) is caused by L1, L2 and L3 serovars of Chlamydia trachomatis. The anorectal syndrome caused by LGV is often misdiagnosed as inflammatory bowel disease and may rarely lead to stricture formation. Recurrent stricture formation, despite adequate LGV treatment, has not to our knowledge, previously been reported.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29748997/the-recycling-endosome-and-bacterial-pathogens
#9
REVIEW
Samual C Allgood, M Ramona Neunuebel
Bacterial pathogens have developed a wide range of strategies to survive within human cells. A number of pathogens multiply in a vacuolar compartment, while others can rupture the vacuole and replicate in the host cytosol. A common theme among many bacterial pathogens is the use of specialized secretion systems to deliver effector proteins into the host cell. These effectors can manipulate the host's membrane trafficking pathways to remodel the vacuole into a replication-permissive niche and prevent degradation...
May 10, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29748180/molecular-test-for-chlamydia-and-gonorrhoea-used-at-point-of-care-in-remote-primary-healthcare-settings-a-diagnostic-test-evaluation
#10
Louise M Causer, Rebecca J Guy, Sepehr N Tabrizi, David M Whiley, David John Speers, James Ward, Annie Tangey, Steven G Badman, Belinda Hengel, Lisa Jane Natoli, David A Anderson, Handan Wand, David Wilson, David G Regan, Mark Shephard, Basil Donovan, Christopher K Fairley, John M Kaldor
OBJECTIVES: A new molecular test for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) (GeneXpert CT/NG) has been demonstrated to be as accurate as conventional nucleic acid amplification tests (NAAT), but performance has not been evaluated in routine primary care, performed at the point of care by clinicians. We aimed to examine its diagnostic performance when used by clinicians in remote community health services in Australia with high prevalences of CT and NG infection. The trial was registered with the Australian and New Zealand Clinical Trials Registry (#12613000808741) METHODS: At 12 health services, training was provided to 99 clinicians in the use of the GeneXpert CT/NG assay who tested specimens from all patients undergoing STI screening...
May 10, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29746924/comparison-of-the-mikrogen-multi-target-elisa-with-the-mikrogen-recomline-immunoblot-for-the-detection-of-chlamydia-trachomatis-igg-antibodies-in-serum-in-infertile-women
#11
E F van Ess, S Ouburg, J A Land, S A Morré
OBJECTIVES: Chlamydia trachomatis (CT) IgG serology is used in many fertility clinics in order to estimate the risk for tubal factor infertility (TFI) in the fertility work-up. The predictive value for TFI of the currently used mono-target CT serology test should be improved. This study compares the performance of the new multi-target Mikrogen recomWell CT IgG ELISA with the Mikrogen recomLine CT immunoblot and visualizes distribution of individual antibodies in serum with the immunoblot in order to potentially improve the current CT IgG serology test that is clinically used...
May 7, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29746535/gonorrhea-chlamydia-and-hiv-incidence-among-female-sex-workers-in-cotonou-benin-a-longitudinal-study
#12
Souleymane Diabaté, Annie Chamberland, Nassirou Geraldo, Cécile Tremblay, Michel Alary
Female sex workers (FSWs) continue to carry a heavy burden of sexually transmitted infections (STI). For prevention purposes, there is a need to identify most-at-risk subgroups among them. The objective of this longitudinal cohort study conducted at Dispensaire IST, Cotonou, Benin, was to assess Neisseria gonorrhoeae (NG) / Chlamydia trachomatis (CT) incidence and determinants; and HIV incidence among FSWs in presence of STI/HIV risk reduction activities. Overall, 319 adult FSWs were followed quarterly from September 2008 to March 2012...
2018: PloS One
https://www.readbyqxmd.com/read/29743811/the-immunoregulation-of-th17-in-host-against-intracellular-bacterial-infection
#13
REVIEW
Yonghong Li, Chaojun Wei, Hui Xu, Jing Jia, Zhenhong Wei, Rui Guo, Yanjuan Jia, Yu Wu, Yuanting Li, Xiaoming Qi, Zhenhao Li, Xiaoling Gao
T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, ROR γ , and ROR α ), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation (TGF- β , IL6, IL21, and IL23). Recent studies involving experimental animals and humans have shown that Th17/IL17 plays a crucial role in host defense against a variety of pathogens, including bacteria and viruses. The underlying mechanisms by which Th17 performs include dendritic cell (DC) regulation, neutrophil recruitment, Th1 modulation, and T regulatory cell (Treg) balance...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29743637/detection-of-chlamydiaceae-and-chlamydia-like-organisms-on-the-ocular-surface-of-children-and-adults-from-a-trachoma-endemic-region
#14
Ehsan Ghasemian, Aleksandra Inic-Kanada, Astrid Collingro, Florian Tagini, Elisabeth Stein, Hadeel Alchalabi, Nadine Schuerer, Darja Keše, Balgesa Elkheir Babiker, Nicole Borel, Gilbert Greub, Talin Barisani-Asenbauer
Trachoma, the leading infectious cause of blindness, is caused by Chlamydia trachomatis (Ct), a bacterium of the phylum Chlamydiae. Recent investigations revealed the existence of additional families within the phylum Chlamydiae, also termed Chlamydia-like organisms (CLOs). In this study, the frequency of Ct and CLOs was examined in the eyes of healthy Sudanese (control) participants and those with trachoma (case). We tested 96 children (54 cases and 42 controls) and 93 adults (51 cases and 42 controls) using broad-range Chlamydiae and Ct-specific (omcB) real-time PCR...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741592/ocular-chlamydia-trachomatis-infection-under-the-safe-strategy-in-amhara-ethiopia-2011-2015
#15
Scott D Nash, Aisha E P Stewart, Mulat Zerihun, Eshetu Sata, Demelash Gessese, Berhanu Melaku, Tekola Endeshaw, Melsew Chanyalew, Ambahun Chernet, Belay Bayissasse, Jeanne Moncada, Thomas M Lietman, Paul M Emerson, Jonathan D King, Zerihun Tadesse, E Kelly Callahan
Background: WHO recommendations for starting and stopping mass antibiotic distributions are based on a clinical sign of trachoma, which is indirectly related to actual infection with the causative agent, Chlamydia trachomatis. Methods: This study aimed to understand the effect of SAFE (surgery, antibiotics, facial cleanliness, and environmental improvement) interventions on ocular chlamydia in Amhara, Ethiopia by describing the infection prevalence in a population-based sample of children ages 1-5 years...
May 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29735758/the-impact-of-active-metabolism-on-chlamydia-trachomatis-elementary-body-transcript-profile-and-infectivity
#16
Scott Grieshaber, Nicole Grieshaber, Hong Yang, Briana Baxter, Ted Hackstadt, Anders Omsland
Bacteria of the genus Chlamydia include the significant human pathogens C. trachomatis and C. pneumoniae All Chlamydiae are obligate intracellular parasites that depend on infection of a host cell and transition through a biphasic developmental cycle. Following host cell invasion by the infectious Elementary Body (EB), the pathogen transitions to the replicative but non-infectious Reticulate Body (RB). Differentiation of the RB back to the EB is essential to generate infectious progeny. While the EB form has historically been regarded as metabolically inert, maintenance of infectivity during incubation with specific nutrients has revealed active maintenance of the infectious phenotype...
May 7, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29729635/an-integrative-investigation-of-the-therapeutic-mechanism-of-ainsliaea-fragrans-champ-in-cervicitis-using-liquid-chromatography-tandem-mass-spectrometry-based-on-a-rat-plasma-metabolomics-strategy
#17
Xiaoyong Zhang, Mingzhen He, Shuangxia Lei, Bei Wu, Ting Tan, Hui Ouyang, Wen Xu, Yulin Feng
Cervicitis is an extremely common gynecological disease and can be induced by diverse factors such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium infections. Long-term unhealed cervicitis may lead to a series of diseases including endometritis, salpingitis, pelvic inflammatory disease, and chorioamnionitis. However, the pathogenesis of cervicitis remains unknown. Ainsliaea fragrans Champ. (AFC) has been widely used in clinical treatment of cervicitis. In the present study, we performed an integrative investigation involving histopathology analysis and non-target plasma metabolomics analysis in a cervicitis rat model induced by phenol mucilage, using ultra-performance liquid chromatography coupled with a tandem quadrupole time-of-flight mass spectrometry approach...
April 27, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29729435/complement-c3-opsonization-of-chlamydia-trachomatis-facilitates-uptake-in-human-monocytes
#18
Mads Lausen, Gunna Christiansen, Nichlas Karred, Robert Winther, Thomas Bouet Guldbæk Poulsen, Yaseelan Palarasah, Svend Birkelund
Chlamydia trachomatis is an obligate intracellular bacterium that causes severe infections, which can lead to infertility and ectopic pregnancy. Although both innate and adaptive immune responses are elicited during chlamydial infection the bacterium succeeds to evade host defense mechanisms establishing chronic infections. Thus, studying the host-pathogen interaction during chlamydial infection is of importance to understand how C. trachomatis can cause chronic infections. Both the complement system and monocytes play essential roles in anti-bacterial defense, and, therefore, we investigated the interaction between the complement system and the human pathogens C...
May 2, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29729331/the-vaginal-microbiota-and-its-association-with-human-papillomavirus-chlamydia-trachomatis-neisseria-gonorrhea-and-mycoplasma-genitalium-infections-a-systematic-review-and-meta-analysis
#19
REVIEW
Jeanne Tamarelle, Anne C M Thiébaut, Bertille de Barbeyrac, Cécile Bébéar, Jacques Ravel, Elisabeth Delarocque-Astagneau
OBJECTIVES: The vaginal microbiota may modulate susceptibility to Human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhea and Mycoplasma genitalium infections. The objective of this meta-analysis was to evaluate the association between these infections and the vaginal microbiota. METHODS: The search (2000-2016) yielded 1054 articles, of which 39 articles meeting the inclusion criteria were analyzed. The vaginal microbiota was dichotomized into high-Lactobacillus vaginal microbiota (HL-VMB) and low-Lactobacillus vaginal microbiota (LL-VMB), using either Nugent score, Amsel's criteria, presence of clue cells or gene sequencing...
May 2, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29727463/chlamydia-exploits-filopodial-capture-and-a-macropinocytosis-like-pathway-for-host-cell-entry
#20
Charlotte Ford, Andrea Nans, Emmanuel Boucrot, Richard D Hayward
Pathogens hijack host endocytic pathways to force their own entry into eukaryotic target cells. Many bacteria either exploit receptor-mediated zippering or inject virulence proteins directly to trigger membrane reorganisation and cytoskeletal rearrangements. By contrast, extracellular C. trachomatis elementary bodies (EBs) apparently employ facets of both the zipper and trigger mechanisms and are only ~400 nm in diameter. Our cryo-electron tomography of C. trachomatis entry revealed an unexpectedly diverse array of host structures in association with invading EBs, suggesting internalisation may progress by multiple, potentially redundant routes or several sequential events within a single pathway...
May 4, 2018: PLoS Pathogens
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