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Chlamydia trachomatis

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https://www.readbyqxmd.com/read/29334204/detection-of-chlamydia-trachomatis-in-pap-smear-samples-from-south-khorasan-province-of-iran
#1
Davod Javanmard, Mahmoodreza Behravan, Malaknaz Ghannadkafi, Alireza Salehabadi, Masood Ziaee, Mohammad Hasan Namaei
Background: Chlamydia trachomatis (CT), the most common bacterial sexually transmitted infection (STI), leads to pelvic inflammatory disease, infertility and chronic pelvic pain in women as well as an increased risk of vertical transmission, conjunctivitis and pneumonitis in infants. It may also be a co-factor along with human papillomavirus (HPV) in cervical cancer progression. We aimed to determine the prevalence of CT genotypes in genital specimens of women from South Khorasan, Iran and to test the association between CT and cytology statistics...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29329181/what-is-the-optimal-time-to-retest-patients-with-a-urogenital-chlamydia-infection-a-randomized-controlled-trial
#2
Jannie J van der Helm, Rik H Koekenbier, Martijn S van Rooijen, Maarten F Schim van der Loeff, Henry J C de Vries
BACKGROUND: Chlamydia trachomatis is a common, often recurring sexually transmitted infection, with serious adverse outcomes in women. Current guidelines recommend retesting after a chlamydia infection, but the optimum timing is unknown. We assessed the optimal retest interval after urogenital chlamydia treatment. METHODS: A randomized controlled trial among urogenital chlamydia nucleic acid amplification test positive heterosexual clients of the Amsterdam sexually transmitted infection clinic...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29329179/should-asymptomatic-men-who-have-sex-with-men-be-screened-for-oropharyngeal-chlamydia-clinical-outcomes-from-a-cross-sectional-study
#3
Jason J Ong, Eric P F Chow, Vesna De Petra, Deborah Williamson, Irene Pelatosis, Ben Howden, Lei Zhang, Marcus Y Chen, Catriona S Bradshaw, Jane Hocking, Christopher K Fairley
OBJECTIVE: To help inform screening guidelines, we estimated the proportion of asymptomatic men who have sex with men (MSM) with oropharyngeal chlamydia. STUDY DESIGN: An audit of asymptomatic MSM attending a sexual health service from March 2015 to April 2016 was conducted. They each had an oropharyngeal swab that was tested for Chlamydia trachomatis by transcription-mediated nucleic acid amplification. In addition, a random sample of 17 swabs that initially tested positive had confirmatory testing to determine the likelihood of true positivity...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29324305/caveolin-mediated-endocytosis-of-the-chlamydia-m278-outer-membrane-peptide-encapsulated-in-poly-lactic-acid-poly-ethylene-glycol-nanoparticles-by-mouse-primary-dendritic-cells-enhances-specific-immune-effectors-mediated-by-mhc-class-ii-and-cd4-t-cells
#4
Saurabh Dixit, Rajnish Sahu, Richa Verma, Skyla Duncan, Guillermo H Giambartolomei, Shree R Singh, Vida A Dennis
We previously developed a Chlamydia trachomatis nanovaccine (PPM) by encapsulating a chlamydial M278 peptide within poly(lactic acid)-poly(ethylene glycol) biodegradable nanoparticles that immunopotentiated Chlamydia-specific immune effector responses in mice. Herein, we investigated the mechanistic interactions of PPM with mouse bone marrow-derived dendritic cells (DCs) for its uptake, trafficking, and T cell activation. Our results reveal that PPM triggered enhanced expression of effector cytokines and chemokines, surface activation markers (Cd1d2, Fcgr1), pathogen-sensing receptors (TLR2, Nod1), co-stimulatory (CD40, CD80, CD86) and MHC class I and II molecules...
December 26, 2017: Biomaterials
https://www.readbyqxmd.com/read/29317940/elisa-serology-for-antibodies-against-chlamydia-trachomatis-in-crohn-s-disease
#5
Herbert J Van Kruiningen, Zeinab Helal, Ariane Leroyer, Antonio Garmendia, Corrine Gower-Rousseau
Background: Recently we reported IgA anti-Chlamydia antibodies in patients with Crohn's disease (CD), in particular in four patients from a single family of six with CD. Methods: We studied sera from four cohorts from the north of France. These were identified as: EPIMAD (80 pediatric onset CD and 20 pediatric onset ulcerative colitis), MINOTOR (148 adult onset sporadic CD and 50 adult onset ulcerative colitis), Grande Famillies (50) and matched controls for the Grande Famillies cohort (49)...
December 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/29314736/development-of-a-chlamydia-suis-specific-antibody-enzyme-linked-immunosorbent-assay-based-on-the-use-of-a-b-cell-epitope-of-the-polymorphic-membrane-protein-c
#6
K De Puysseleyr, E Kieckens, L De Puysseleyr, H Van den Wyngaert, B Ahmed, S Van Lent, H H Creasy, G S A Myers, D Vanrompay
Chlamydia suis infections lead to economic loss in the pork industry. Chlamydia suis infections could be successfully treated with tetracyclines until the appearance of a tetracycline resistant phenotype, which was acquired via horizontal gene transfer of the tet(C) gene. Given the importance of C. suis as a swine pathogen and as a recently emerged tetracycline resistant pathogen with zoonotic potential, our aim was to develop a sensitive C. suis-specific antibody ELISA based on the polymorphic membrane proteins (Pmps)...
January 4, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29313867/hpv-chlamydia-trachomatis-co-infection-metagenomic-analysis-of-cervical-microbiota-in-asymptomatic-women
#7
Marisa Di Pietro, Simone Filardo, Maria Grazia Porpora, Nadia Recine, Maria Agnese Latino, Rosa Sessa
HPV and Chlamydia trachomatis are the most common causes of sexually transmitted diseases worldwide. Most infections are asymptomatic and left untreated lead to severe reproductive tract sequelae such as cervical cancer and infertility. Interestingly, C. trachomatis may also increase the susceptibility to HPV infection as well as contribute to viral persistence. Recently, a growing body of evidence has suggested that the composition of the cervico-vaginal microbiota plays a key role in the susceptibility and outcome of genital infections caused by several pathogens, including HPV and C...
January 9, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29306870/gender-differences-in-the-well-being-of-patients-diagnosed-with-chlamydia-trachomatis-a-cross-sectional-study
#8
Nirina Andersson, Helena Carré, Urban Janlert, Jens Boman, Elisabet Nylander
OBJECTIVES: We aimed to investigate how an infection with Chlamydia trachomatis (CT) influenced patients' well-being and whether there were differences due to gender, age or relationship status, in an effort to strengthen preventive measures and provide better healthcare for patients with CT. METHODS: Patients diagnosed with CT in the county of Västerbotten, Sweden, were asked to fill out a questionnaire about their feelings, thoughts and actions after CT diagnosis...
January 6, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29304083/combined-evaluation-of-sexually-transmitted-infections-in-hiv-infected-pregnant-women-and-infant-hiv-transmission
#9
Kristina Adachi, Jiahong Xu, Nava Yeganeh, Margaret Camarca, Mariza G Morgado, D Heather Watts, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Jack Moye, Jeffrey D Klausner, Claire C Bristow, Ruth Dickover, Mark Mirochnick, Karin Nielsen-Saines
BACKGROUND: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040. METHODOLOGY: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV...
2018: PloS One
https://www.readbyqxmd.com/read/29298975/replication-dependent-size-reduction-precedes-differentiation-in-chlamydia-trachomatis
#10
Jennifer K Lee, Germán A Enciso, Daniela Boassa, Christopher N Chander, Tracy H Lou, Sean S Pairawan, Melody C Guo, Frederic Y M Wan, Mark H Ellisman, Christine Sütterlin, Ming Tan
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection. It produces an unusual intracellular infection in which a vegetative form, called the reticulate body (RB), replicates and then converts into an elementary body (EB), which is the infectious form. Here we use quantitative three-dimensional electron microscopy (3D EM) to show that C. trachomatis RBs divide by binary fission and undergo a sixfold reduction in size as the population expands. Conversion only occurs after at least six rounds of replication, and correlates with smaller RB size...
January 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29289422/chlamydia-spreading-from-the-genital-tract-to-the-gastrointestinal-tract-a-two-hit-hypothesis
#11
REVIEW
Guangming Zhong
Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model pathogen for investigating C. trachomatis pathogenesis, readily spreads from the mouse genital tract to the gastrointestinal tract, establishing long-lasting colonization. C. muridarum mutants, despite their ability to activate acute oviduct inflammation, are attenuated in inducing tubal fibrosis and are no longer able to colonize the gastrointestinal tract, suggesting that the spread of C...
December 27, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/29288183/performance-of-syndromic-management-for-the-detection-and-treatment-of-genital-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-among-women-attending-antenatal-well-woman-and-sexual-health-clinics-in-papua-new-guinea-a-cross-sectional-study
#12
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Josephine Gabuzzi, Joyce Allen, Christine Opa, Gloria Munnull, Petronia Kaima, Benny Kombuk, Antonia Kumbia, Zure Kombati, Greg Law, Angela Kelly-Hanku, Handan Wand, Peter M Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29287991/t-cell-phenotypes-in-women-with-chlamydia-trachomatis-infection-and-influence-of-treatment-on-phenotype-distributions
#13
Brian M O Ogendi, Rakesh K Bakshi, Kanupriya Gupta, Richa Kapil, LaDraka T Brown, Stephen J Jordan, Steffanie Sabbaj, Christen G Press, Jeannette Y Lee, William M Geisler
T cell phenotypes involved in the immune response to Chlamydia trachomatis (CT) have not been fully elucidated in humans. We evaluated differences in T cell phenotypes between CT-infected women and CT-seronegative controls and investigated changes in T cell phenotype distributions after CT treatment and their association with reinfection. We found a higher expression of T cell activation markers (CD38+HLA-DR+), T helper type 1 (Th1)- and Th2-associated effector phenotypes (CXCR3+CCR5+ and CCR4+, respectively), and T cell homing marker (CCR7) for both CD4+ and CD8+ T cells in CT-infected women...
December 26, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29284768/fitz-hugh-curtis-syndrome-caused-by-gonococcal-infection-in-a-patient-with-systemic-lupus-erythematous-a-case-report-and-literature-review
#14
Darío A Rueda, Luisina Aballay, Lisandro Orbea, Diego A Carrozza, Paola Finocchietto, Silvia B Hernandez, Mariano M Volpacchio, Horacio di Fonzo
BACKGROUND Fitz-Hugh-Curtis (FHC) syndrome is a perihepatitis linked to inflammatory pelvic disease. It can be caused by Neisseria gonorrhoeae or Chlamydia trachomatis infections. FHC syndrome usually presents with pain in the right hypochondrium and fever, associated with symptoms and signs of pelvic infection in women. CASE REPORT We present the case of a 22-year-old woman with systemic lupus erythematous (SLE) who presented with polyarthritis, cutaneous lesions, and abdominal pain. The diagnosis of FHC syndrome was based on the findings of abdominal computerized tomography (CT) and the isolation of Neisseria gonorrhoeae (NG) in blood cultures...
December 29, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29282889/comparison-of-reverse-hybridization-and-ompa-sequencing-methods-applied-on-chlamydia-trachomatis-strains-from-tunisia
#15
Houda Gharsallah, Olfa Frikha-Gargouri, Reinier J Bom, Adnene Hammami, Sylvia M Bruisten
Two techniques based on ompA amplification of Chlamydia trachomatis were compared, being reverse hybridization (RHM) and ompA sequencing (OSA), to investigate the concordance between them and to study the epidemiological relevance of each method. In addition, phylogenetic analysis was performed on the ompA sequences. One hundred and seven C. trachomatis positive samples from Tunisian patients and female sex workers were analyzed using both the RHM and ompA sequencing. The overall genovar distribution obtained with both techniques was very similar...
December 28, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29282126/the-impact-of-a-single-round-of-community-mass-treatment-with-azithromycin-on-disease-severity-and-ocular-chlamydia-trachomatis-load-in-treatment-na%C3%A3-ve-trachoma-endemic-island-communities-in-west-africa
#16
Anna R Last, Sarah E Burr, Emma Harding-Esch, Eunice Cassama, Meno Nabicassa, Chrissy H Roberts, David C W Mabey, Martin J Holland, Robin L Bailey
BACKGROUND: Trachoma, a neglected tropical disease, is caused by ocular infection with Chlamydia trachomatis (Ct). The World Health Organization (WHO) recommends three annual rounds of community mass drug treatment with azithromycin (MDA) if the prevalence of follicular trachoma in 1-9 year olds (TF1-9) exceeds 10% at district level to achieve an elimination target of district-level TF1-9 below 5% after. To evaluate this strategy in treatment-naïve trachoma-endemic island communities in Guinea Bissau, we conducted a cross-sectional population-based trachoma survey on four islands...
December 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29279452/prevalence-and-genotype-distribution-of-chlamydia-trachomatis-in-urine-among-men-attending-std-clinics-in-guangdong-province-china-2016
#17
Yaohua Xue, Heping Zheng, Weiming Tang, Zhida Mai, Jinmei Huang, Shujie Huang, Xiaolin Qin, Lei Chen, Lei Zheng
Studies rarely assessed the genotype distribution of chlamydia trachomatis (CT) in urine among men attending STD clinics (MSCs) in China. This study aimed to investigate the prevalence and molecular epidemiology of CT infection by examining urine samples among MSCs from different geographic areas of Guangdong province, China. A cross-sectional study was conducted among MSCs from ten HIV sentinel surveillance sites in Guangdong province. CT DNA in men urine samples were extracted and detected by using the Roche cobas® 4800 CT/NG...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29278958/clinical-significance-of-pregnancy-in-adolescence-in-japan
#18
Shunji Suzuki
OBJECTIVE: We examined the clinical characteristics and obstetric outcomes in adolescent pregnancies in Japanese women. METHODS: The present study was a retrospective investigation of all primiparous Japanese women with singleton pregnancies who gave birth at ≥ 22 weeks' gestation aged ≤ 18 years old (adolescent pregnancy, n = 325) and aged 28-30 years old (n = 2029) at Japanese Red Cross, Katsushika Maternity Hospital between 2002 and 2016. RESULTS: The frequencies of smoking, economic problems, an unmarried single status at delivery and the start of prenatal care in the first trimester in the adolescent pregnancy group were significantly higher than in the control group (p < 0...
December 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29276602/the-eyes-have-it-an-unusual-case-of-escherichia-coli-ophthalmia-neonatorum-or-a-shifting-landscape
#19
Walid Mounir Maalouli, Michael Barclay Pitt
Despite dramatic declines in the incidence of ophthalmia neonatorum with universal prophylaxis, it remains a clinically important cause of eye disease in newborns. While clear guidelines exist for the treatment of the historically primary agents of ophthalmia neonatorum (Chlamydia trachomatis and Neisseria gonorrhoeae), it is less clear how to manage newborns with conjunctivitis secondary to other bacterial organisms, particularly those also frequently implicated in neonatal sepsis. We present the case of a 3-day-old well-appearing term infant with unilateral purulent conjunctivitis...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29273004/impact-of-hpv-vaccination-with-gardasil%C3%A2-in-switzerland
#20
Martine Jacot-Guillarmod, Jérôme Pasquier, Gilbert Greub, Massimo Bongiovanni, Chahin Achtari, Roland Sahli
BACKGROUND: Gardasil®, a quadrivalent vaccine targeting low-risk (6, 11) and high-risk (16, 18) human papillomaviruses (HPV), has been offered to 11-14 year-old schoolgirls in Switzerland since 2008. To evaluate its success and its potential impact on cervical cancer screening, HPV genotypes were examined in 18-year-old girls five years later (sub-study 1) and in outpatients participating to cervical cancer screening before and after vaccine implementation (sub-study 2). METHODS: For sub-study 1, 3726 females aged 18 in 2013 were invited to fill a questionnaire on personal demographics and HPV risk factors and to provide a self-collected cervicovaginal sample for HPV genotyping and Chlamydia trachomatis PCR...
December 22, 2017: BMC Infectious Diseases
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