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Chlamydia trachomatis

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https://www.readbyqxmd.com/read/28918430/distribution-of-chlamydia-trachomatis-genotypes-in-infective-diseases-of-the-female-lower-genital-tract
#1
Yujie Chen, Jing Chen, Lan Yang, Yanming Jiang, Li Li, Wenjuan Yi, Lifang Lan, Liuhong Zhang
The purpose of this study was to investigate the distribution of Chlamydia trachomatis (CT) genotypes in infective diseases of the female lower genital tract, especially in cervical diseases. This study included 128 CT-positive women. DNA was extracted from cervical swabs. Omp1 gene PCR-RFLP and sequencing were used to confirm the subtypes of CT. The association of subtypes with age, clinical symptoms, cervical cytology, and biopsy results was further analyzed. Omp1 gene PCR-RFLP and sequencing showed that the order of prevalent CT genotypes in the female lower genital tract was D (n=38, 29...
September 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28918068/a-simple-and-rapid-dna-extraction-method-for-chlamydia-trachomatis-detection-from-urogenital-swabs
#2
Matthew A Butzler, Jennifer L Reed, Sally M McFall
A highly sensitive and specific Chlamydia trachomatis (CT) diagnostic test was developed by combining filtration isolation of nucleic acid (FINA) extraction with quantitative polymerase chain reaction including an internal control to identify test inhibition. A pilot study of 40 clinical specimens yielded 100% sensitivity and specificity.
August 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28915869/frequency-and-genotypes-of-chlamydia-trachomatis-in-patients-attending-the-obstetrics-and-gynecology-clinics-in-jalisco-mexico-and-correlation-with-sociodemographic-behavioral-and-biological-factors
#3
Néstor Casillas-Vega, Rayo Morfín-Otero, Santos García, Jorge Llaca-Díaz, Eduardo Rodríguez-Noriega, Adrián Camacho-Ortiz, Ma de la Merced Ayala-Castellanos, Héctor J Maldonado-Garza, Jesús Ancer-Rodríguez, Guadalupe Gallegos-Ávila, Alberto Niderhauser-García, Elvira Garza-González
BACKGROUND: Chlamydia trachomatis is the causative agent of the most common bacterial sexually transmitted infection worldwide. The aim of this study was to investigate the frequency and genotypes of C. trachomatis in patients attending an obstetrics and gynecology clinic in Jalisco, Mexico and correlates them with sociodemographic, behavioral, and biological factors. METHODS: C. trachomatis detection was performed in endocervical samples from 662 patients by direct fluorescence assay (DFA) and two PCR assays that amplified the phospholipase D endonuclease superfamily protein (PLDESP) and OmpA genes...
September 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28914654/accuracy-of-tests-used-to-detect-infection-with-chlamydia-trachomatis-in-asymptomatic-pregnant-women-a-systematic-review
#4
Siew-Veena Sahi, Ewelina Rogozińska, Soha Sobhy, Khalid S Khan
PURPOSE OF REVIEW: Infection with Chlamydia trachomatis in pregnancy is linked to increased risk of miscarriage, stillbirth, and preterm birth. Currently, PCR or DNA-based tests are the gold standard when detecting the infection; however, they are costly and require access to specialist equipment. The aim of this systematic review was to assess the accuracy of available tests to detect infection in an asymptomatic pregnant population. RECENT FINDINGS: There was evidence of the superior accuracy of nucleic acid amplification tests to cell culture in nonpregnant asymptomatic women; however, there are multiple commercial nucleic acid amplification tests with varying sensitivities and specificities...
September 12, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28913832/corrigendum-rapid-and-visual-chlamydia-trachomatis-detection-using-loop-mediated-isothermal-amplification-and-hydroxynaphthol-blue
#5
I Choopara, N Arunrut, W Kiatpathomchai, D Dean, N Somboonna
No abstract text is available yet for this article.
October 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28913776/interactions-of-antisera-to-different-chlamydia-and-chlamydophila-species-with-the-ribosomal-protein-rps27a-correlate-with-impaired-protein-synthesis-in-a-human-choroid-plexus-papilloma-cell-line
#6
Abdullah Almamy, Christian Schwerk, Horst Schroten, Hiroshi Ishikawa, Abdul Rahman Asif, Bernhard Reuss
Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a...
September 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28912770/infectious-agents-as-markers-of-human-migration-toward-the-amazon-region-of-brazil
#7
REVIEW
Ricardo Ishak, Luiz F A Machado, Izaura Cayres-Vallinoto, Marluísa de O Guimarães Ishak, Antonio C R Vallinoto
Infectious agents are common companions of humans and since ancient times they follow human migration on their search for a better place to live. The study of paleomicrobiology was significantly improved in its accuracy of measurement with the constant development of better methods to detect and analyze nucleic acids. Human tissues are constantly used to trace ancient infections and the association of anthropological evidences are important to confirm the microbiological information. Infectious agents which establish human persistent infections are particularly useful to trace human migrations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#8
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28898240/prevalence-of-signs-of-trachoma-ocular-chlamydia-trachomatis-infection-and-antibodies-to-pgp3-in-residents-of-kiritimati-island-kiribati
#9
Anaseini Cama, Andreas Müller, Raebwebwe Taoaba, Robert M R Butcher, Iakoba Itibita, Stephanie J Migchelsen, Tokoriri Kiauea, Harry Pickering, Rebecca Willis, Chrissy H Roberts, Ana Bakhtiari, Richard T Le Mesurier, Neal D E Alexander, Diana L Martin, Rabebe Tekeraoi, Anthony W Solomon
OBJECTIVE: In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most populous Kiribati island, both the active trachoma sign "trachomatous inflammation-follicular" (TF) and TT are present at prevalences warranting intervention. We sought to estimate prevalences of TF, TT, ocular Ct infection, and anti-Ct antibodies on Kiritimati Island, Kiribati, to assess local relationships between these parameters, and to help determine the need for interventions against trachoma on Kiribati islands other than Tarawa...
September 12, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28883273/regression-of-uterine-cervical-diffuse-large-b-cell-lymphoma-transformed-from-mucosa-associated-lymphoid-tissue-lymphoma-subsequent-to-chlamydia-trachomatis-eradication
#10
Toshitaka Mutoh, Hiroshi Takatsuki, Kiyohito Mannoji, Kyoko Kawamura, Naofumi Okura, Koichi Ohshima
A 37-year-old-woman was referred to our center after her uterine cervix health screening presented abnormal findings. We performed a biopsy of the uterine cervix to examine for cervical dysplasia, and diagnosed a diffuse large B-cell lymphoma transformed from mucosa-associated lymphoid tissue (MALT) lymphoma of the cervix. The patient presented with concurrent chlamydial cervicitis and received eradication therapy for Chlamydia trachomatis. Four months later, the CD20 positive abnormal lymphocyte disappeared and complete remission was achieved...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28878094/male-genital-tract-immune-response-against-chlamydia-trachomatis-infection
#11
REVIEW
Juan Pablo Mackern-Oberti, Rubén Darío Motrich, Maria Teresa Damiani, Héctor Alex Saka, Cristian Andrés Quintero, Leonardo Rodolfo Sánchez, Tamara Moreno-Sosa, Carolina Olivera, Cecilia Cuffini, Virginia Elena Rivero
Chlamydia trachomatis is the most commonly reported agent of sexually transmitted bacterial infections worldwide. This pathogen frequently leads to persistent, long-term, subclinical infections, which in turn may cause severe pathology in susceptible hosts. This is in part due to the strategies that Chlamydia trachomatis uses to survive within epithelial cells and to evade the host immune response, such as subverting intracellular trafficking, interfering signaling pathways and preventing apoptosis. Innate immune receptors such as toll-like receptors expressed on epithelial and immune cells in the genital tract mediate the recognition of chlamydial molecular patterns...
October 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28878004/mycoplasma-genitalium-macrolide-and-fluoroquinolone-resistance-detection-and-clinical-implications-in-a-selected-cohort-in-new-zealand
#12
Trevor Anderson, Edward Coughlan, Anja Werno
Mycoplasma genitalium has been associated with infections of the genitourinary tract and prevalence is secondary to Chlamydia trachomatis The clinical observation of increasing treatment failure indicating antibiotic resistance, especially in cases of recurrent urethritis, has been confirmed by molecular testing. Mutations in the 23S rRNA gene can cause macrolide resistance and topoisomerase/gyrase mutations can cause fluoroquinolone resistance. In this study, 115 M. genitalium DNA positive samples were analysed...
September 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28876312/screening-for-sexually-transmitted-infections-in-adolescent-girls-and-young-women-in-mombasa-kenya-feasibility-prevalence-and-correlates
#13
Linnet N Masese, George Wanje, Emmanuel Kabare, Valentine Budambula, Francis Mutuku, Grace Omoni, Anisa Baghazal, Barbra A Richardson, R Scott McClelland
INTRODUCTION: As adolescents and young women become sexually active, they are at risk of adverse reproductive health outcomes including sexually transmitted infections (STIs). We assessed feasibility and acceptability of STI screening among 15- to 24-year-old women in Mombasa, Kenya. METHODS: After sensitization activities, participants were recruited from 3 high schools and 1 university. Study staff conducted informational sessions. Students interested in participating were given consent forms to take home, and invited to visit our clinic for STI screening...
June 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876302/seroprevalence-of-chlamydia-trachomatis-in-inner-city-children-and-adolescents-implications-for-vaccine-development
#14
Natalie Banniettis, Sirisha Thumu, Jeremy Weedon, Kobkul Chotikanatis, Aviva Szigeti, Margaret R Hammerschlag, Stephan A Kohlhoff
BACKGROUND: Prevention of Chlamydia trachomatis infection is an ideal application for a vaccine program, which should optimally be administered before sexual debut. However, there are limited epidemiologic studies of C. trachomatis infection in an unselected pediatric population since routine screening and treatment of pregnant women was implemented in the United States in 1993. METHODS: Anonymized serum samples were obtained from children younger than 21 years in 2 medical centers in Brooklyn, New York, from 2013 to 2015...
July 19, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28876291/prevalence-of-gonorrhea-and-chlamydia-testing-by-anatomical-site-among-men-who-have-sex-with-men-in-hiv-medical-care-united-states-2013-2014
#15
Monita R Patel, John T Brooks, Yunfeng Tie, Shikha Garg, Heather Bradley
Fewer than one-third of men who have sex with men were tested for Neisseria gonorrhoeae or Chlamydia trachomatis as part of HIV medical care in the United States in 2013 to 2014, and only 11.6% were tested for either sexually transmitted disease at an extragenital site.
August 22, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28871927/sociodemographic-sexual-behavior-and-microbiological-profiles-of-men-attending-public-health-laboratories-for-testing-for-sexually-transmitted-diseases
#16
Mario Sviben, Sunčanica Ljubin-Sternak, Tomislav Meštrović, Jasmina Vraneš
In order to identify the groups at risk of sexually transmitted diseases (STDs), we assessed the sociodemographic profiles of men testing for STD, their sexual habits, and the results of microbiological analysis. During a three-year period, a total of 700 men older than 18 years of age completed the questionnaire regarding sociodemographic and sexual behavior. Urethral swabs were taken for microbiological analysis. Thirty-three percent of respondents reported not using condoms. Those that do not use condoms were predominantly less educated, unmarried but in steady relationships, employed, with children, and smokers...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28868962/prevalence-of-mycoplasma-genitalium-and-other-sexually-transmitted-infections-causing-urethritis-among-high-risk-heterosexual-male-patients-in-estonia
#17
Stanislav Tjagur, Reet Mändar, Margus Punab
BACKGROUND: We aimed to evaluate the prevalence of sexually transmitted infections (STI, including Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis) among high-risk heterosexual male patients and to clarify their potency to cause complaints and inflammation. METHODS: The study group included 825 men (18.0-49.5 y) consulting andrologist at Tartu University Hospital (Estonia) due to subjectively perceived risk of STI. Patients completed STI risk behaviour questionnaire...
September 4, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28867456/antimicrobial-activity-of-bitespiramycin-a-new-genetically-engineered-macrolide
#18
Weiqing He, Chunping Yang, Xiaofeng Zhao, Yiguang Wang
The antimicrobial activity of bitespiramycin (BT) against Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cp), Ureaplasma urealyticum (Uu), and Mycoplasma pneumoniae (Mp), was compared with those of azithromycin (AZM) and acetylspiramycin (AT-SP) in vitro. Furthermore, the anti-Mp activities of BT and AZM were evaluated in a hamster model. The activities of BT in vitro were similar to those of AZM but were more effective than those of AT-SP. BT effectively inhibited Mp infection at a dose of 200mg/kg in a hamster model...
August 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28864426/il-6-mediated-signaling-pathways-limit-chlamydia-muridarum-infection-and-exacerbate-its-pathogenicity-in-the-mouse-genital-tract
#19
Xin Sun, Qi Tian, Luying Wang, Min Xue, Guangming Zhong
Chlamydia muridarum induction of mouse hydrosalpinx, depending on both tubal infection and inflammation, has been used for investigating Chlamydia trachomatis pathogenesis. We now report that IL-6 both inhibits C. muridarum infection and exacerbates pathogenicity in the mouse genital tract. When intravaginally inoculated with a high dose of C. muridarum, IL-6-deficient mice developed more extensive genital tract infection with severe hydrosalpinx, suggesting that IL-6 is required for controlling the high dose infection but not essential for C...
August 31, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28864236/crossing-the-border-solute-entry-into-the-chlamydial-inclusion
#20
REVIEW
Ilka Haferkamp
Chlamydiales comprise important human and animal pathogens as well as endosymbionts of amoebae. Generally, these obligate intracellular living bacteria are characterized by a biphasic developmental cycle, a reduced genome and a restricted metabolic capacity. Because of their metabolic impairment, Chlamydiales essentially rely on the uptake of diverse metabolites from their hosts. Chlamydiales thrive in a special compartment, the inclusion, and hence are surrounded by an additional membrane. Solutes might enter the inclusion through pores and open channels or by redirection of host vesicles, which fuse with the inclusion membrane and release their internal cargo...
August 26, 2017: International Journal of Medical Microbiology: IJMM
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