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Neisseria gonorrhea

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https://www.readbyqxmd.com/read/27898572/sexually-transmitted-infections-and-associated-risk-factors-among-street-based-and-residence-based-female-sex-workers-in-dhaka-bangladesh
#1
Rasheda Khanam, Masud Reza, Dilruba Ahmed, Mustafizur Rahman, M Shah Alam, Salima Sultana, Anadil Alam, Sharful I Khan, Kenneth H Mayer, Tasnim Azim
BACKGROUND: Female sex workers (FSWs) in Bangladesh remain at elevated risk of sexually transmitted infections (STIs) although the human immunodeficiency virus (HIV) prevalence among them is low. Recent information on the burden and etiological diagnosis of STIs among them has been lacking. This study examines prevalence and risk behaviors of selected STIs among FSWs in Dhaka in 2014. METHODS: Between August and October 2014, a cross-sectional study was conducted among street-based and residence-based FSWs receiving HIV prevention services at 24 drop in centers in Dhaka...
November 28, 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27885067/repeat-infection-with-neisseria-gonorrhoeae-among-active-duty-u-s-army-personnel-a-population-based-case-series-study
#2
Christian T Bautista, Eyako K Wurapa, Warren B Sateren, Sara M Morris, Bruce P Hollingsworth, Jose L Sanchez
Little information is known on the rate of repeat gonorrhea infection among U.S. military personnel. We analyzed all gonorrhea cases reported to the Defense Medical Surveillance System during 2006-2012 to determine the rate of repeat infection. During the seven-year study period, 17,602 active duty U.S. Army personnel with a first incident gonorrhea infection were reported. Among the 4987 women with a first gonorrhea infection, 14.4% had at least one repeat infection. Among the 12,615 men with a first gonorrhea infection, 13...
November 24, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27871917/gonococcal-conjunctivitis-a-case-report-of-an-unusual-mode-of-transmission
#3
Anna Jo Bodurtha Smith, Samuel B Holzman, Reza Sedighi Manesh, Trish M Perl
BACKGROUND: Outside of the newborn period, development of gonococcal conjunctivitis is rare and predominantly occurs through auto-inoculation. We report an unusual case of gonococcal conjunctivitis in a young woman exposed through direct inoculation. CASE: A 19-year-old woman presented with purulent ocular discharge, severe pain, and decreased vision unresponsive to topical antibiotics or ganciclovir approximately 3 weeks after accidental ocular exposure to seminal fluid during unprotected oral sex...
November 18, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27836225/impact-of-rapid-diagnostic-testing-for-chlamydia-and-gonorrhea-on-appropriate-antimicrobial-utilization-in-the-emergency-department
#4
Kaitlyn R Rivard, Lisa E Dumkow, Heather M Draper, Kasey L Brandt, David W Whalen, Nnaemeka E Egwuatu
Prolonged turnaround time of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) test results may delay time to notification and treatment of test-positive patients and result in unnecessary antimicrobial use in test-negative patients. This quasi-experimental study evaluated the impact of NG/CT rapid diagnostic testing (RDT) in an urban emergency department (ED) on treatment appropriateness, time to notification, and cost. Patients tested in December 2013-January 2014 (traditional group, n=200) were compared with those in December 2014-January 2015 (RDT group, n=200)...
October 18, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27816380/association-of-bacterial-vaginosis-with-chlamydia-and-gonorrhea-among-women-in-the-u-s-army
#5
Christian T Bautista, Eyako K Wurapa, Warren B Sateren, Sara M Morris, Bruce P Hollingsworth, Jose L Sanchez
INTRODUCTION: Bacterial vaginosis (BV) is a common vaginal condition in women of reproductive age, which has been associated with Chlamydia trachomatis and Neisseria gonorrhoeae among commercial sex workers and women attending sexually transmitted infection clinics. Pathogen-specific associations between BV and other sexually transmitted infections among U.S. military women have not been investigated. METHODS: A population-based, nested case-control study was conducted of all incident chlamydia and gonorrhea cases reported to the Defense Medical Surveillance System during 2006-2012...
November 2, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27736753/gentamicin-susceptibility-among-a-sample-of-multi-drug-resistant-neisseria-gonorrhoeae-isolates-in-india
#6
Manju Bala, Vikram Singh, Aradhana Bhargava, Monika Kakran, Naveen Chandra Joshi, Ravi Bhatnagar
Antimicrobial susceptibility testing of 258 N. gonorrhoeae isolates by Etest determined that 60.1% were MDR while 5% strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (ESCs). Among these, 84.5% MDR and 76.9% strains having decreased susceptibility to ESCs were susceptible to gentamicin. No MDR isolate was resistant to gentamicin. These in vitro results suggest that gentamicin might be an effective treatment option for the MDR strains and in dual therapy for gonorrhea...
October 10, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27638945/genomic-epidemiology-of-gonococcal-resistance-to-extended-spectrum-cephalosporins-macrolides-and-fluoroquinolones-in-the-united-states-2000-2013
#7
Yonatan H Grad, Simon R Harris, Robert D Kirkcaldy, Anna G Green, Debora S Marks, Stephen D Bentley, David Trees, Marc Lipsitch
BACKGROUND:  Treatment of Neisseria gonorrhoeae infection is empirical and based on population-wide susceptibilities. Increasing antimicrobial resistance underscores the potential importance of rapid diagnostic tests, including sequence-based tests, to guide therapy. However, the usefulness of sequence-based diagnostic tests depends on the prevalence and dynamics of the resistance mechanisms. METHODS:  We define the prevalence and dynamics of resistance markers to extended-spectrum cephalosporins, macrolides, and fluoroquinolones in 1102 resistant and susceptible clinical N...
November 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27626188/gonorrhea-in-indonesia-high-prevalence-of-asymptomatic-urogenital-gonorrhea-but-no-circulating-extended-spectrum-cephalosporins-resistant-neisseria-gonorrhoeae-strains-in-jakarta-yogyakarta-and-denpasar-indonesia
#8
I Putu Yuda Hananta, Alje P van Dam, Sylvia Maria Bruisten, Maarten Franciscus Schim van der Loeff, Hardyanto Soebono, Henry John Christiaan de Vries
BACKGROUND: Little is known about the epidemiology of asymptomatic urogenital gonorrhea and antimicrobial susceptibility of Neisseria gonorrhoeae (NG) strains circulating in Indonesia. We studied these issues in 3 large Indonesian cities. METHODS: In 2014, participants were recruited from sexually transmitted infection clinics and through outreach in Jakarta, Yogyakarta, and Denpasar. Neisseria gonorrhoeae detection in genital specimens was performed with NG-qPCR at the Public Health Service in Amsterdam...
October 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27619365/neisseria-gonorrhoeae-among-suspects-of-sexually-transmitted-infection-in-gambella-hospital-ethiopia-risk-factors-and-drug-resistance
#9
Seada Ali, Tsegaye Sewunet, Zewdineh Sahlemariam, Gebre Kibru
BACKGROUND: Neisseria gonorrhoeae is a bacterium responsible for one of the classic sexually transmitted infection (STI) gonorrhea. Antibiotic resistant strains are emerging at alarming rate. Multiple sexual partners, unsafe sex and substance use habits are the main host related risk factors for acquiring the infection. Thus, this study aimed at determining the magnitude, its determinants and antimicrobial resistance profile of N. gonorrhoeae in a place where there is risk related cultural practices and relatively high HIV prevalence...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27596531/in-silico-hierarchical-approach-for-the-identification-of-potential-universal-vaccine-candidates-puvcs-from-neisseria-gonorrhoeae
#10
Ravi Jain, Subash C Sonkar, Uma Chaudhry, Manju Bala, Daman Saluja
OBJECTIVES: Resistance to the currently recommended extended-spectrum cephalosporins, which is used to treat Gonorrhea, is increasing continuously and leading to a threat of untreatable infection. It is, therefore, becoming extremely essential to search for new therapeutic strategies to control Gonorrhea. Vaccination may be considered as an effective control measure to control this disease, which is caused by Neisseria gonorrhoeae. METHODS: In-silico hierarchical approach was used to help identify candidate proteins of N...
September 3, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27583786/increased-gonorrhea-cases-utah-2009-2014
#11
Joanna Watson, Jerry Carlile, Angela Dunn, Megan Evans, Erin Fratto, Joel Hartsell, Lynn Meinor, Matthew Mietchen, Allyn Nakashima
Gonorrhea (caused by infection with Neisseria gonorrhoeae) is the second most commonly reported notifiable disease in the United States (1). Left untreated, gonorrhea is associated with serious long-term adverse health effects, including pelvic inflammatory disease, ectopic pregnancy, and infertility. Infection also facilitates transmission of human immunodeficiency virus (2,3). Effective gonorrhea control relies upon early detection and effective antimicrobial treatment. To assess gonorrhea rate trends in Utah, the Utah Department of Health (UDOH) analyzed Utah National Electronic Disease Surveillance System (UT-NEDSS) data for the state during 2009-2014...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27582306/sexually-transmitted-infections-other-than-hiv-aids-among-women-of-low-socio-economic-class-attending-antenatal-clinics-in-khartoum-sudan
#12
Nada A Abdelrahim, Hiba I Ahmed, Imad M Fadl-Elmula, Magdi A Bayoumi, Mamoun M Homeida
Sexually transmitted infections (STIs) are major health threats affecting people globally; however, the burden of STIs is greatest in low-income countries. Since they are physiologically more vulnerable, women are mostly affected. The risk is increased dramatically during pregnancy leading to serious health complications that may affect the newborn. Underprivileged pregnant women attending antenatal clinics for routine checkups in displaced camps, a women's prison and several peripheral health centres were clinically and laboratory screened for trichomoniasis, chlamydial infections, gonorrhea and syphilis...
August 31, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27570316/draft-genome-sequence-of-neisseria-gonorrhoeae-strain-ng_869-with-penicillin-tetracycline-and-ciprofloxacin-resistance-determinants-isolated-from-malaysia
#13
Geik Yong Ang, Choo Yee Yu, Delicia Ann Yong, Yuet Meng Cheong, Wai-Fong Yin, Kok-Gan Chan
Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae and the increasing reports of multidrug-resistant gonococcal isolates are a global public health care concern. Herein, we report the genome sequence of N. gonorrhoeae strain NG_869 isolated from Malaysia which may provide insights into the drug resistance determinants in gonococcal bacteria.
June 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27551020/neisseria-gonorrhoeae-crippled-its-peptidoglycan-fragment-permease-to-facilitate-toxic-peptidoglycan-monomer-release
#14
Jia Mun Chan, Joseph P Dillard
: Neisseria gonorrhoeae (gonococci) and Neisseria meningitidis (meningococci) are human pathogens that cause gonorrhea and meningococcal meningitis, respectively. Both N. gonorrhoeae and N. meningitidis release a number of small peptidoglycan (PG) fragments, including proinflammatory PG monomers, although N. meningitidis releases fewer PG monomers. The PG fragments released by N. gonorrhoeae and N. meningitidis are generated in the periplasm during cell wall remodeling, and a majority of these fragments are transported into the cytoplasm by an inner membrane permease, AmpG; however, a portion of the PG fragments are released into the extracellular environment through unknown mechanisms...
November 1, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27548425/committee-opinion-no-645-dual-therapy-for-gonococcal-infections
#15
(no author information available yet)
Gonorrhea is the second most commonly reported bacterial sexually transmitted disease in the United States, with an estimated 820,000 new Neisseria gonorrhoeae infections occurring each year. Antimicrobial resistance limits treatment success, heightens the risk of complications, and may facilitate the transmission of sexually transmitted infections. Neisseria gonorrhoeae has developed resistance to the sulfonamides, the tetracyclines, and penicillin. Dual therapy with ceftriaxone and azithromycin remains the only recommended first-line regimen for the treatment of gonorrhea in the United States...
May 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27548417/committee-opinion-no-645-summary-dual-therapy-for-gonococcal-infections
#16
(no author information available yet)
Gonorrhea is the second most commonly reported bacterial sexually transmitted disease in the United States, with an estimated 820,000 new Neisseria gonorrhoeae infections occurring each year. Antimicrobial resistance limits treatment success, heightens the risk of complications, and may facilitate the transmission of sexually transmitted infections. Neisseria gonorrhoeae has developed resistance to the sulfonamides, the tetracyclines, and penicillin. Dual therapy with ceftriaxone and azithromycin remains the only recommended first-line regimen for the treatment of gonorrhea in the United States...
May 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27506628/difference-in-dna-binding-abilities-of-fur-homolog-dna-binding-protein-from-neisseria-gonorrhoeae
#17
Angshuman Bagchi
Gonorrhea is a severe disease infecting both men and women worldwide. The causative agent of the disease is Neisseria gonorrhoeae. The organism mostly affects human beings in iron restricted environments. In such an environment the organism produces a set of proteins which are mostly absent in iron rich environments. The expressions of the genes for the proteins are regulated by the transcription factor (TF) belonging to the Fur family. Interestingly, the same TF acts as the activator and repressor of genes...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27471316/does-the-cervicovaginal-microbiome-facilitate-transmission-of-neisseria-gonorrhoeae-from-women-to-men-implications-for-understanding-transmission-of-gonorrhea-and-advancing-vaccine-development
#18
https://www.readbyqxmd.com/read/27414503/neisseria-gonorrhoeae-antimicrobial-susceptibility-surveillance-the-gonococcal-isolate-surveillance-project-27-sites-united-states-2014
#19
Robert D Kirkcaldy, Alesia Harvey, John R Papp, Carlos Del Rio, Olusegun O Soge, King K Holmes, Edward W Hook, Grace Kubin, Stefan Riedel, Jonathan Zenilman, Kevin Pettus, Tremeka Sanders, Samera Sharpe, Elizabeth Torrone
PROBLEM/CONDITION: Gonorrhea is the second most commonly reported notifiable disease in the United States; 350,062 gonorrhea cases were reported in 2014. Sexually transmitted infections caused by Neisseria gonorrhoeae are a cause of pelvic inflammatory disease in women, which can lead to serious reproductive complications including tubal infertility, ectopic pregnancy, and chronic pelvic pain. Prevention of sequelae and of transmission to sexual partners relies largely on prompt detection and effective antimicrobial treatment...
2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/27381912/analyzing-neisseria-gonorrhoeae-pilin-antigenic-variation-using-454-sequencing-technology
#20
Ella Rotman, David M Webber, H Steven Seifert
UNLABELLED: Many pathogens use homologous recombination to vary surface antigens in order to avoid immune surveillance. Neisseria gonorrhoeae, the bacterium responsible for the sexually transmitted infection gonorrhea, achieves this in part by changing the sequence of the major subunit of the type IV pilus in a process termed pilin antigenic variation (Av). The N. gonorrhoeae chromosome contains one expression locus (pilE) and many promoterless, partial-coding silent copies (pilS) that act as reservoirs for variant pilin information...
September 15, 2016: Journal of Bacteriology
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