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Neisseria gonorrhea

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https://www.readbyqxmd.com/read/28549097/cluster-of-neisseria-gonorrhoeae-isolates-with-high-level-azithromycin-resistance-and-decreased-ceftriaxone-susceptibility-hawaii-2016
#1
Alan R Katz, Alan Y Komeya, Robert D Kirkcaldy, A Christian Whelen, Olusegun O Soge, John R Papp, Ellen N Kersh, Glenn M Wasserman, Norman P O'Connor, Pamela S O'Brien, Douglas T Sato, Eloisa V Maningas, Gail Y Kunimoto, Juval E Tomas
Background.: The Centers for Disease Control and Prevention (CDC) currently recommends dual therapy with ceftriaxone and azithromycin for gonorrhea to ensure effective treatment and slow emergence of antimicrobial resistance. Since 2013, the prevalence of reduced azithromycin susceptibility increased in the United States; however, these strains were highly susceptible to cephalosporins. We report on a cluster of N. gonorrhoeae isolates demonstrating high-level azithromycin resistance, several of which also demonstrated decreased ceftriaxone susceptibility...
May 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28545411/antimicrobial-susceptibility-of-neisseria-gonorrhoeae-isolates-from-hefei-2014-2015-genetic-characteristics-of-antimicrobial-resistance
#2
Fa-Xing Jiang, Qian Lan, Wen-Jing Le, Xiao-Hong Su
BACKGROUND: Antimicrobial resistance (AMR) and genetic determinants of resistance of N. gonorrhoeae isolates from Hefei, China, were characterized adding a breadth of information to the molecular epidemiology of gonococcal resistance in China. METHODS: 126 N. gonorrhoeae isolates from a hospital clinic in Hefei, were collected between January, 2014, and November, 2015. The minimum inhibitory concentration (MIC) of N. gonorrhoeae isolates for seven antimicrobials were determined by the agar dilution method...
May 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28528844/prevalence-of-chlamydia-trachomatis-and-neisseria-gonorrhea-and-associated-factors-among-women-living-with-human-immunodeficiency-virus-in-brazil-a-multicenter-study
#3
Angelica E Miranda, Mariangela F Silveira, Ana Gabriela Travassos, Teresinha Tenório, Isabel Cristina Chulvis do Val, Leonor de Lannoy Tavares, Hortensio Simões de Mattos Junior, Newton Sergio de Carvalho
BACKGROUND: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) cause infections in the female genital tract, increasing susceptibility to and infectiousness of HIV. The objectives of the present study were to determine the prevalence and associated factors of CT and GC infection among HIV-infected women in Brazil. METHODS: Cross-sectional study conducted from March to December 2015, including HIV-infected women attending referral centers in nine states of Brazil, aged 18-49 years, nonpregnant...
May 18, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28505240/incidence-of-gonorrhea-and-chlamydia-following-hiv-preexposure-prophylaxis-among-men-who-have-sex-with-men-a-modeling-study
#4
Samuel M Jenness, Kevin M Weiss, Steven M Goodreau, Thomas Gift, Harrell Chesson, Karen W Hoover, Dawn K Smith, Albert Y Liu, Patrick S Sullivan, Eli S Rosenberg
Background: Preexposure prophylaxis (PrEP) is highly effective for preventing HIV, but risk compensation (RC) in men who have sex with men (MSM) raises concerns about increased sexually transmitted infections (STIs). CDC's PrEP guidelines recommend biannual STI screening, which may reduce incidence by treating STIs that would otherwise remain undiagnosed. We investigated the impact of these two potentially counteracting phenomena. Methods: With a stochastic network-based mathematical model of HIV and rectal/urogenital Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) transmission dynamics among MSM in the United States, we simulated PrEP uptake following the prescription indications and HIV/STI screening recommendations in the CDC guidelines...
May 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28499285/keeping-an-eye-on-chlamydia-and-gonorrhea-conjunctivitis-in-infants-in-the-united-states-2010-2015
#5
Kristen Kreisel, Emily Weston, Jim Braxton, Eloisa Llata, Elizabeth Torrone
Perinatal transmission of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) can result in conjunctivitis in infants. We examined national rates of reported CT/GC conjunctivitis among infants. Surveillance of these infections is heavily affected by the completeness of reported data on specimen source and age. Alternative data sources should be evaluated.
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28462398/the-frequency-of-gonorrheal-and-chlamydial-infections-in-zanjanian-women-in-2013-2014
#6
Behnaz Molaei, Farnaz Mohmmadian, Maryam Eftekhar, Robabeh Hatami, Atefe Tirkan, Mahsa Kiani
BACKGROUND: Chlamydia trachomatis and Neisseria gonorrhoeae are the most prevalent bacterial sexually transmitted diseases in women. OBJECTIVE: The purpose of this study was to investigate the prevalence of gonorrheal and chlamydial infections and determination of related risk factors in married women with vaginal discharge attending gynecological outpatient department (OPD) in Zanjan in 2013-2014. MATERIALS AND METHODS: In this cross sectional study, 100 married women aged 18-49 years with vaginal discharge were evaluated for signs and symptoms of gonococcal and chlamydial infections...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28460033/gonococcal-lipooligosaccharide-sialylation-virulence-factor-and-target-for-novel-immunotherapeutics
#7
Sanjay Ram, Jutamas Shaughnessy, Rosane B de Oliveira, Lisa A Lewis, Sunita Gulati, Peter A Rice
Gonorrhea has become resistant to most conventional antimicrobials used in clinical practice. The global spread of multidrug-resistant isolates of Neisseria gonorrhoeae could lead to an era of untreatable gonorrhea. New therapeutic modalities with novel mechanisms of action that do not lend themselves to the development of resistance are urgently needed. Gonococcal lipooligosaccharide (LOS) sialylation is critical for complement resistance and for establishing infection in humans and in experimental mouse models...
April 27, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28446378/ceftriaxone-susceptibility-and-molecular-characteristics-of-neisseria-gonorrhoeae-isolates-in-changsha-china
#8
Ting Peng, Hui Lin, Qinglin Liu, Wei Cao, Hui Ding, Jianlin Chen, Lingli Tang
A total of 128 Neisseria gonorrhoeae isolates were consecutively obtained in Changsha, China, between April 2015 and June 2016. The minimum inhibitory concentrations (MICs) of ceftriaxone were measured by agar dilution method for each isolate. Ceftriaxone resistance determinants involving penA, mtrR, porB and ponA were amplified by PCR, and the PCR products were sequenced. N. gonorrhoeae multi-antigen sequence typing (NG-MAST) was conducted for genotyping. The results exhibited 11% (14/128) of isolates were reduced susceptibility or resistant to ceftriaxone...
April 23, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28428838/a-national-strategic-plan-for-reducing-the-burden-of-sexually-transmitted-infections-in-israel-by-the-year-2025
#9
Daniel Chemtob, Dan Gandacu, Zohar Mor, Itamar Grotto, Emilia Anis, Elliot Rosenberg
BACKGROUND: There is on ongoing debate in the literature regarding the real burden of STIs (sexually transmitted infections) in Western countries and the proper strategies needed to estimate and to prevent them. Our purpose is to present an evidence-based national strategic plan for STI prevention in Israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience. METHODS: Epidemiologic and health policy data on STIs were analyzed from various sources: a) systematic national surveillance data for the years 2002-2014; b) the international scientific literature (published between 2002-16; keywords: Sexually Transmitted Diseases (STD) (or STI) AND prevention AND intervention AND gonorrhea OR chlamydia OR syphilis; c) internal Ministry of Health (MOH) analyses and reports, and d) expert opinion...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28414664/gonococcal-endocarditis-the-gift-that-stops-giving-an-uncommon-presentation-of-a-common-disease
#10
G Olayemi, M Oferczak, A Elagizi, I El-Abbassi, M Eschete, J Crowe
INTRODUCTION: Gonorrhea is the 2nd most common sexually transmitted disease in the US with 800,000 cases of gonorrhea each year. Disseminated gonorrhea infection occurs in 0.5 percent - 3 percent of these patients and is more frequent in woman younger than 40 years of age. CASE: A 36 year old woman with a history of polysubstance abuse presented with 10 day history of feeling generally unwell. At presentation, vitals were remarkable for tachycardia and hypotension...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28407641/adverse-birth-outcomes-and-maternal-neisseria-gonorrhoeae-infection-a-population-based-cohort-study-in-washington-state
#11
Christine L Heumann, Laura A S Quilter, McKenna C Eastment, Renee Heffron, Stephen E Hawes
BACKGROUND: Neisseria gonorrhoeae (gonorrhea) remains an important cause of reproductive and obstetric complications. There has been limited population-based research to evaluate the association between maternal gonorrhea and adverse birth outcomes. METHODS: A population-based retrospective cohort study was conducted of women with singleton pregnancies in Washington State from 2003 to 2014 using linked birth certificate and birth hospitalization discharge data. The exposed cohort consisted of women with gonorrhea diagnosed during pregnancy...
May 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28406994/neisseria-gonorrhoeae-infects-the-human-endocervix-by-activating-non-muscle-myosin-ii-mediated-epithelial-exfoliation
#12
Liang-Chun Wang, Qian Yu, Vonetta Edwards, Brian Lin, Jessica Qiu, Jerrold R Turner, Daniel C Stein, Wenxia Song
Colonization and disruption of the epithelium is a major infection mechanism of mucosal pathogens. The epithelium counteracts infection by exfoliating damaged cells while maintaining the mucosal barrier function. The sexually transmitted bacterium Neisseria gonorrhoeae (GC) infects the female reproductive tract primarily from the endocervix, causing gonorrhea. However, the mechanism by which GC overcome the mucosal barrier remains elusive. Using a new human tissue model, we demonstrate that GC can penetrate into the human endocervix by inducing the exfoliation of columnar epithelial cells...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28400529/control-of-gdhr-expression-in-neisseria-gonorrhoeae-via-autoregulation-and-a-master-repressor-mtrr-of-a-drug-efflux-pump-operon
#13
Corinne E Rouquette-Loughlin, Yaramah M Zalucki, Vijaya L Dhulipala, Jacqueline T Balthazar, Raúl G Doyle, Robert A Nicholas, Afrin A Begum, Erica L Raterman, Ann E Jerse, William M Shafer
The MtrCDE efflux pump of Neisseria gonorrhoeae contributes to gonococcal resistance to a number of antibiotics used previously or currently in treatment of gonorrhea, as well as to host-derived antimicrobials that participate in innate defense. Overexpression of the MtrCDE efflux pump increases gonococcal survival and fitness during experimental lower genital tract infection of female mice. Transcription of mtrCDE can be repressed by the DNA-binding protein MtrR, which also acts as a global regulator of genes involved in important metabolic, physiologic, or regulatory processes...
April 11, 2017: MBio
https://www.readbyqxmd.com/read/28387837/genomic-sequencing-of-neisseria-gonorrhoeae-to-respond-to-the-urgent-threat-of-antimicrobial-resistant-gonorrhea
#14
A Jeanine Abrams, David L Trees
The development of resistance of Neisseria gonorrhoeae to available first-line antibiotics, including penicillins, tetracyclines, fluoroquinolones and cephalosporins, has led to the circulation of multidrug-resistant gonorrhea at a global scale. Advancements in high-throughput whole-genome sequencing (WGS) provide useful tools that can be used to enhance gonococcal detection, treatment and management capabilities, which will ultimately aid in the control of antimicrobial resistant gonorrhea worldwide. In this minireview, we discuss the application of WGS of N...
June 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28373547/emergence-of-a-new-neisseria-meningitidis-clonal-complex-11-lineage-11-2-clade-as-an-effective-urogenital-pathogen
#15
Yih-Ling Tzeng, Jose A Bazan, Abigail Norris Turner, Xin Wang, Adam C Retchless, Timothy D Read, Evelyn Toh, David E Nelson, Carlos Del Rio, David S Stephens
Neisseria meningitidis (Nm) clonal complex 11 (cc11) lineage is a hypervirulent pathogen responsible for outbreaks of invasive meningococcal disease, including among men who have sex with men, and is increasingly associated with urogenital infections. Recently, clusters of Nm urethritis have emerged primarily among heterosexual males in the United States. We determined that nonencapsulated meningococcal isolates from an ongoing Nm urethritis outbreak among epidemiologically unrelated men in Columbus, Ohio, are linked to increased Nm urethritis cases in multiple US cities, including Atlanta and Indianapolis, and that they form a unique clade (the US Nm urethritis clade, US_NmUC)...
April 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28369241/neisseria-models-of-infection-and-persistence-in-the-upper-respiratory-tract
#16
REVIEW
Nathan J Weyand
The Gram-negative bacteria genus Neisseria includes both pathogenic and commensal species that are found primarily in the upper respiratory tract of humans and animals. The development of animal models to study neisserial pathogenesis has focused almost exclusively on two species that cause disease in humans. These include Neisseria meningitidis, an obligate commensal that can cause invasive disease, and N. gonorrhoeae, the causative agent of gonorrhea. Both pathogens can persist in the upper respiratory tract...
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28357376/gonorrhea-an-evolving-disease-of-the-new-millennium
#17
REVIEW
Stuart A Hill, Thao L Masters, Jenny Wachter
Etiology, transmission and protection: Neisseria gonorrhoeae (the gonococcus) is the etiological agent for the strictly human sexually transmitted disease gonorrhea. Infections lead to limited immunity, therefore individuals can become repeatedly infected. Pathology/symptomatology: Gonorrhea is generally a non-complicated mucosal infection with a pustular discharge. More severe sequellae include salpingitis and pelvic inflammatory disease which may lead to sterility and/or ectopic pregnancy. Occasionally, the organism can disseminate as a bloodstream infection...
September 5, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28329941/-genital-chlamydia-trachomatis-infection-and-associated-risk-factors-in-male-clients-attending-sexually-transmitted-disease-clinics-in-9-cities-in-guangdong-province
#18
H C Shen, S J Huang, X L Qin, P Z Zhao, Y Y Lan, H C Zou, J L Ou, L Chen, X M Luo, H P Zheng, Y Li, B Yang
Objective: To investigate the prevalence of genital Chlamydia trachomatis (GCT) infection and associated risk factors in male clients attending sexually transmitted disease (STD) clinics in Guangdong and provide integrated intervention strategy for this group. Methods: Convenient sampling was used to recruit participants from April to June in 2015 in Guangdong province. The information about their socio-demographic characteristics and sexual behaviors were collected by using a questionnaire, and blood samples were taken from them to test the antibodies against HIV, syphilis and HCV...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28329470/cutaneous-manifestations-of-disseminated-gonococcemia
#19
Surget V Beatrous, Stratton B Grisoli, Ryan R Riahi, Ryan J Matherne, Ryan J Matherne
BACKGROUND: Sexually transmitted infections, includingurogenital gonorrheal infection, are a growing healthconcern in the United States. Nearly 50% of cervicalinfections are asymptomatic. If left undiagnosedand untreated, there is a risk of disseminatedinfection. PURPOSE: To describe an 18-year-old womanpresenting with disseminated gonococcal infectionconfirmed by blood cultures, skin biopsy, and urinegonococcal probe. We also describe the presentation,diagnosis, and treatment of disseminated gonococcalinfection, including discussion of the variousmorphologies of cutaneous lesions that have beenreported in the literature...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28282644/antimicrobial-susceptibility-evaluation-and-multiple-locus-variable-number-tandem-repeat-analysis-of-neisseria-gonorrhoeae-isolates-in-china-in-2012
#20
Rui-Xing Yu, Yueping Yin, Xiu-Qin Dai, Shao-Chun Chen, Yan Han, Bing-Jie Zheng, Guo-Yi Zhang, Xiang-Sheng Chen
OBJECTIVE: This study aimed to gain information on the antimicrobial susceptibility and molecular epidemiological typing of Neisseria gonorrhoeae (NG) isolates in China in 2012. METHODS: A total of 244 NG isolates were consecutively recovered from patients with uncomplicated gonorrhea attending sexually transmitted disease clinics in 3 Chinese cities-Guangzhou, Nanjing, and Tianjin-in 2012. Neisseria gonorrhoeae susceptibilities to penicillin and tetracycline were examined by detecting penicillinase-producing NG (PPNG) and high-level tetracycline-resistant NG, and NG susceptibilities to ciprofloxacin, spectinomycin, ceftriaxone, and cefixime were determined using an agar dilution method...
April 2017: Sexually Transmitted Diseases
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