keyword
MENU ▼
Read by QxMD icon Read
search

Septin

keyword
https://www.readbyqxmd.com/read/27891501/septins-and-bacterial-infection
#1
REVIEW
Vincenzo Torraca, Serge Mostowy
Septins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002. Since then, work has shown that septins assemble in response to a wide variety of invasive bacterial pathogens, and septin assemblies can have different roles during the bacterial infection process. Here we review the interplay between septins and bacterial pathogens, highlighting septins as a structural determinant of host defense...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27882315/septin-mutations-in-human-cancers
#2
REVIEW
Dimitrios Angelis, Elias T Spiliotis
Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS oncogenes. Septin expression levels are altered in many cancers and new advances point to how abnormal septin expression may contribute to the progression of cancer. In contrast to the RAS GTPases, which are frequently mutated and actively promote tumorigenesis, little is known about the occurrence and role of septin mutations in human cancers. Here, we review septin missense mutations that are currently in the Catalog of Somatic Mutations in Cancer (COSMIC) database...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27878927/the-septin-protein-sep4-facilitates-host-infection-by-plant-fungal-pathogens-via-mediating-initiation-of-infection-structure-formation
#3
Hui-Qiang Feng, Gui-Hua Li, Du Shun-Wen, Song Yang, Xue-Qian Li, Paul de Figueiredo, Qing-Ming Qin
Many phytopathogenic fungi use infection structures (IFSs, i.e., appressoria and infection cushions) to penetrate host cuticles. However, the conserved mechanisms that mediate initiation of IFS formation in divergent pathogens upon sensing the presence of host plants remain obscure. Here, we demonstrate that a conserved septin gene SEP4 plays crucial roles in this process. Disruption of SEP4 in the plant gray mold fungus Botrytis cinerea completely blocked IFS formation and abolished the virulence of ΔBcsep4 mutants on unwounded hosts...
November 23, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27878118/cancer-related-functions-and-subcellular-localizations-of-septins
#4
REVIEW
Christian Poüs, Laurence Klipfel, Anita Baillet
Since the initial discovery of septin family GTPases, the understanding of their molecular organization and cellular roles keeps being refined. Septins have been involved in many physiological processes and the misregulation of specific septin gene expression has been implicated in diverse human pathologies, including neurological disorders and cancer. In this minireview, we focus on the importance of the subunit composition and subcellular localization of septins relevant to tumor initiation, progression, and metastasis...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27866222/the-cytoskeletal-protein-septin-11-is-associated-with-human-obesity-and-is-involved-in-adipocyte-lipid-storage-and-metabolism
#5
Natalia Moreno-Castellanos, Amaia Rodríguez, Yoana Rabanal-Ruiz, Alejandro Fernández-Vega, José López-Miranda, Rafael Vázquez-Martínez, Gema Frühbeck, María M Malagón
AIMS/HYPOTHESIS: Septins are newly identified members of the cytoskeleton that have been proposed as biomarkers of a number of diseases. However, septins have not been characterised in adipose tissue and their relationship with obesity and insulin resistance remains unknown. Herein, we characterised a member of this family, septin 11 (SEPT11), in human adipose tissue and analysed its potential involvement in the regulation of adipocyte metabolism. METHODS: Gene and protein expression levels of SEPT11 were analysed in human adipose tissue...
November 19, 2016: Diabetologia
https://www.readbyqxmd.com/read/27857942/septins-as-modulators-of-endo-lysosomal-membrane-traffic
#6
REVIEW
Kyungyeun Song, Giulia Russo, Michael Krauss
Septins constitute a family of GTP-binding proteins, which assemble into non-polar filaments in a nucleotide-dependent manner. These filaments can be recruited to negatively charged membrane surfaces. When associated with membranes septin filaments can act as diffusion barriers, which confine subdomains of distinct biological functions. In addition, they serve scaffolding roles by recruiting cytosolic proteins and other cytoskeletal elements. Septins have been implicated in a large variety of membrane-dependent processes, including cytokinesis, signaling, cell migration, and membrane traffic, and several family members have been implicated in disease...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27857941/septin-organization-and-functions-in-budding-yeast
#7
REVIEW
Oliver Glomb, Thomas Gronemeyer
The septins are a conserved family of GTP-binding proteins present in all eukaryotic cells except plants. They were originally discovered in the baker's yeast Saccharomyces cerevisiae that serves until today as an important model organism for septin research. In yeast, the septins assemble into a highly ordered array of filaments at the mother bud neck. The septins are regulators of spatial compartmentalization in yeast and act as key players in cytokinesis. This minireview summarizes the recent findings about structural features and cell biology of the yeast septins...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27847804/septin-associated-protein-kinases-in-the-yeast-saccharomyces-cerevisiae
#8
REVIEW
Adam M Perez, Gregory C Finnigan, Françoise M Roelants, Jeremy Thorner
Septins are a family of eukaryotic GTP-binding proteins that associate into linear rods, which, in turn, polymerize end-on-end into filaments, and further assemble into other, more elaborate super-structures at discrete subcellular locations. Hence, septin-based ensembles are considered elements of the cytoskeleton. One function of these structures that has been well-documented in studies conducted in budding yeast Saccharomyces cerevisiae is to serve as a scaffold that recruits regulatory proteins, which dictate the spatial and temporal control of certain aspects of the cell division cycle...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27811987/a-critical-role-of-solute-carrier-22a14-in-sperm-motility-and-male-fertility-in-mice
#9
Shin-Ya Maruyama, Momoe Ito, Yuusuke Ikami, Yu Okitsu, Chizuru Ito, Kiyotaka Toshimori, Wataru Fujii, Keiichiro Yogo
We previously identified solute carrier 22a14 (Slc22a14) as a spermatogenesis-associated transmembrane protein in mice. Although Slc22a14 is a member of the organic anion/cation transporter family, its expression profile and physiological role have not been elucidated. Here, we show that Slc22a14 is crucial for sperm motility and male fertility in mice. Slc22a14 is expressed specifically in male germ cells, and mice lacking the Slc22a14 gene show severe male infertility. Although the overall differentiation of sperm was normal, Slc22a14(-/-) cauda epididymal spermatozoa showed reduced motility with abnormal flagellar bending...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806918/effects-of-bni5-binding-on-septin-filament-organization
#10
Elizabeth A Booth, Sarah M Sterling, Dustin Dovala, Eva Nogales, Jeremy Thorner
Septins are a protein family found in all eukaryotes (except higher plants) that have roles in membrane remodeling and formation of diffusion barriers and as a scaffold to recruit other proteins. In budding yeast, proper execution of cytokinesis and cell division requires the formation of a collar of circumferential filaments at the bud neck. These filaments are assembled from apolar septin hetero-octamers. Currently, little is known about the mechanisms that control the arrangement and dynamics of septin structures...
October 30, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27799369/-back-to-back-mechanisms-drive-actomyosin-ring-closure-during-drosophila-embryo-cleavage
#11
Zenghui Xue, Anna Marie Sokac
Contraction of actomyosin rings during cytokinesis is typically attributed to actin filaments sliding toward each other via Myosin-2 motor activity. However, rings constrict in some cells in the absence of Myosin-2 activity. Thus, ring closure uses Myosin-2-dependent and -independent mechanisms. But what the Myosin-2-independent mechanisms are, and to what extent they are sufficient to drive closure, remains unclear. During cleavage in Drosophila melanogaster embryos, actomyosin rings constrict in two sequential and mechanistically distinct phases...
November 7, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27753040/evaluation-of-different-blood-collection-tubes-and-blood-storage-conditions-for-the-preservation-and-stability-of-cell-free-circulating-dna-for-the-analysis-of-the-methylated-m-sept9-colorectal-cancer-screening-marker
#12
Jurgen Distler, Reimo Tetzner, Gunter Weiss, Thomas König, Anne Schlegel, Michal Bagrowski
For the subsequent analysis of the methylated mSEPT9 colorectal cancer screening marker in plasma, different blood collection tubes and blood storage conditions were investigated. The study demonstrated that methylated Septin 9 ((m)SEPT9) can be consistently detected in plasma samples derived from whole blood samples collected with S-Monovette® K3E and BD Vacutainer ® K2EDTA tubes stored at 2-8 °C for a maximum of 24 h and for samples collected in S-Monovette CPDA tubes stored at 18-25 °C for up to 48 h...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27726005/formation-of-nanotube-like-protrusions-regulation-of-septin-organization-and-re-guidance-of-vesicle-traffic-by-depolymerization-of-the-actin-cytoskeleton-induced-by-binary-bacterial-protein-toxins
#13
Carsten Schwan, Klaus Aktories
A large group of bacterial protein toxins, including binary ADP-ribosylating toxins, modify actin at arginine-177, thereby actin polymerization is blocked and the actin cytoskeleton is redistributed. Modulation of actin functions largely affects other components of the cytoskeleton, especially microtubules and septins. Here, recent findings about the functional interconnections of the actin cytoskeleton with microtubules and septins, affected by bacterial toxins, are reviewed.
September 20, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27715407/septin-complexes-assemble-during-a-kinetic-window-of-opportunity
#14
Andrew A Bridges, Amy S Gladfelter
No abstract text is available yet for this article.
November 2016: Cell Cycle
https://www.readbyqxmd.com/read/27695782/transcriptomic-signature-of-high-dietary-organic-selenium-supplementation-in-sheep-a-nutrigenomic-insight-using-a-custom-microarray-platform-and-gene-set-enrichment-analysis
#15
R Elgendy, M Giantin, F Castellani, L Grotta, F Palazzo, M Dacasto, G Martino
The objective of this study was to investigate the effect of a high dietary Se supplementation on the whole transcriptome of sheep. A custom sheep whole-transcriptome microarray, with more than 23,000 unique transcripts, was designed and then used to profile the global gene expression of sheep after feeding a high dietary supplementation of organic Se. Lactating crossbred ewes ( = 10; 3 to 4 yr of age and 55 to 65 kg BW) at late lactation (100 ± 8 d in milk) were acclimated to indoor individual pen feeding of a basal control diet (0...
August 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27687162/biophysical-dissection-of-schistosome-septins-insights-into-oligomerization-and-membrane-binding
#16
Ana Eliza Zeraik, Margarita Staykova, Marina Gabriel Fontes, Indrė Nemuraitė, Roy Quinlan, Ana Paula Ulian Araújo, Ricardo DeMarco
Septins are GTP-binding proteins that are highly conserved among eukaryotes and which are usually membrane-associated. They have been linked to several critical cellular functions such as exocytosis and ciliogenesis, but little mechanistic detail is known. Their assembly into filaments and membrane binding properties are incompletely understood and that is specially so for non-human septins where such information would offer therapeutic potential. In this study we use Schistosoma mansoni, exhibiting just four septin genes, as a simpler model for characterizing the septin structure and organization...
September 26, 2016: Biochimie
https://www.readbyqxmd.com/read/27679846/dissection-of-molecular-assembly-dynamics-by-tracking-orientation-and-position-of-single-molecules-in-live-cells
#17
Shalin B Mehta, Molly McQuilken, Patrick J La Riviere, Patricia Occhipinti, Amitabh Verma, Rudolf Oldenbourg, Amy S Gladfelter, Tomomi Tani
Regulation of order, such as orientation and conformation, drives the function of most molecular assemblies in living cells but remains difficult to measure accurately through space and time. We built an instantaneous fluorescence polarization microscope, which simultaneously images position and orientation of fluorophores in living cells with single-molecule sensitivity and a time resolution of 100 ms. We developed image acquisition and analysis methods to track single particles that interact with higher-order assemblies of molecules...
October 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27666337/the-septins-facdc3-and-facdc12-are-required-for-cytokinesis-and-affect-asexual-and-sexual-development-lipid-metabolism-and-virulence-in-fusarium-asiaticum
#18
Yu Zhang, Tao Gao, Wenyong Shao, Zhitian Zheng, Mingguo Zhou, Changjun Chen
Septins are a highly conserved family of GTP-binding proteins that contribute to many cellular and metabolic functions including cell polarity, cytokinesis, cell morphogenesis and pathogenesis. In this study, we characterized the septins FaCdc3 and FaCdc12 in the filamentous fungus F. asiaticum. The functions of FaCdc3 and FaCdc12 were evaluated by constructing deletion mutants of FaCdc3 and FaCdc12, designated ΔFaCdc3-5 and ΔFaCdc12-71, respectively. The deletion mutants exhibited a reduced rate of mycelial growth, increased aerial hyphae formation, irregularly shaped hyphae, reduced conidiation and a lack of sexual reproduction in wheat kernels...
September 26, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27664992/transcript-levels-of-the-aspergillus-fumigatus-cdc42-module-polarisome-and-septin-genes-show-little-change-from-dormancy-to-polarity-establishment
#19
Ken Oda, Elaine Bignell, S Earl Kang, Michelle Momany
Aspergillus fumigatus is the most common airborne pathogen causing fatal mycoses in immunocompromised patients. During the first 8 hours of development A. fumigatus conidia break dormancy, expand isotopically, establish an axis of polarity, and begin to extend germ tubes in a polar manner. The transition from isotropic to polar growth is critical for tissue invasion and pathogenesis. In the current work, we used two-color microarrays to examine the A. fumigatus transcriptome during early development, focusing on the isotropic to polar switch...
September 24, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27634570/septin7-regulates-inner-ear-formation-at-an-early-developmental-stage
#20
Hiroko Torii, Atsuhiro Yoshida, Tatsuya Katsuno, Takayuki Nakagawa, Juichi Ito, Koichi Omori, Makoto Kinoshita, Norio Yamamoto
Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiological functions of many mammalian cell types including the regulation of microtubule stability, vesicle trafficking, cortical rigidity, planar cell polarity, and apoptosis. The inner ear, which perceives auditory and equilibrium sensation with highly differentiated hair cells, has a complicated gross morphology...
September 12, 2016: Developmental Biology
keyword
keyword
13115
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"