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https://www.readbyqxmd.com/read/28742263/progesterone-receptor-modulators-for-endometriosis
#1
REVIEW
Jing Fu, Hao Song, Min Zhou, Huili Zhu, Yuhe Wang, Hengxi Chen, Wei Huang
BACKGROUND: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. OBJECTIVES: To assess the effectiveness and safety of PRMs primarily in terms of pain relief as compared with other treatments or placebo or no treatment in women of reproductive age with endometriosis...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28739415/human-factors-evaluation-of-surgeons-working-positions-for-gynaecological-minimal-access-surgery
#2
Sue Hignett, Diane Gyi, Lisa Calkins, Laura Jones, Esther Moss
STUDY OBJECTIVE: To investigate work-related musculoskeletal disorders (WRMSD) in gynaecological minimal access surgery (MAS), including bariatric (plus size) patients DESIGN: Mixed methods DESIGN CLASSIFICATION: Level III (descriptive and qualitative) SETTING: UK Teaching Hospital PATIENTS: Not applicable INTERVENTIONS: Not applicable MEASUREMENTS: Survey, observations (anthropometry, postural analysis) and interviews. RESULTS: WRMSD were present in 63% of survey respondents (n=67)...
July 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28736678/rapid-assessment-zika-virus-knowledge-among-clinical-specialists-in-singapore-a-cross-sectional-survey
#3
Chee F Yung, Clarence C Tam, Victor S Rajadurai, Jerry Ky Chan, Mabel Sf Low, Yong H Ng, Koh C Thoon, Lay K Tan
INTRODUCTION: We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore. METHODS: Between June 6 and June 19, 2016 we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. The survey included 15 multiple choice questions to measure respondents' knowledge of Zika virus in four domains covering clinical and public health. RESULTS: A total of 110 survey responses (15% response rate) were obtained, 82% of respondents worked in the public sector...
May 3, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28733062/remote-recurrence-of-benign-multicystic-peritoneal-mesothelioma
#4
Caroline E Lee, Anita Agrawal
BACKGROUND: Benign peritoneal cystic mesothelioma (BPCM) is a rare disease entity that arises from mesothelioma cells. We describe a rare case of BPCM recurrence 36 years after its initial presentation. CASE: A 62-year-old woman was referred to an outpatient gynaecologic oncology clinic with an incidental finding of multiple pelvic cysts. She had a preceding history of known BPCM treated with extensive debulking surgery. She presented after 36 years of clinical remission...
July 18, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28733060/developing-a-canadian-curriculum-for-simulation-based-education-in-obstetrics-and-gynecology-a-delphi-study
#5
Catherine Craig, Glenn D Posner
OBJECTIVE: As obstetrics and gynaecology (Ob/Gyn) residency training programs move towards a competence-based approach to training and assessment, the development of a national standardized simulation curriculum is essential. The primary goal of this study was to define the fundamental content for the Canadian Obstetrics and Gynecology Simulation curriculum. METHODS: A modified Delphi technique was used to achieve consensus in three rounds by surveying residency program directors or their local simulation educator delegates in 16 accredited Canadian Ob/Gyn residency programs...
July 18, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28729416/cib2-negatively-regulates-oncogenic-signaling-in-ovarian-cancer-via-sphingosine-kinase-1
#6
Wenying Zhu, Kate E Jarman, Noor A Lokman, Heidi A Neubauer, Lorena T Davies, Briony L Gliddon, Houng Taing, Paul A B Moretti, Martin K Oehler, Melissa R Pitman, Stuart M Pitson
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between pro-apoptotic and pro-survival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which is mediated by the calcium and integrin binding protein CIB1 via its Ca(2+)-myristoyl switch function. Here we show that another member of the CIB family, CIB2, plays a surprisingly opposite role to CIB1 in the regulation of SK1 signalling. CIB2 bound SK1 on the same site as CIB1, yet it lacks the Ca(2+)-myristoyl switch function...
July 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28729099/implementing-a-cervical-sentinel-lymph-node-biopsy-program-quality-improvement-in-gynaecologic-oncology
#7
Maria C Cusimano, Rachel Walker, Marcus Q Bernardini, Geneviève Bouchard-Fortier, Stephane Laframboise, Taymaa May, Joan Murphy, Barry Rosen, Al Covens, Blaise Clarke, Patricia Shaw, Marjan Rouzbahman, Ravi Mohan, Sarah E Ferguson
OBJECTIVE: Sentinel lymph node (SLN) biopsy is becoming a reasonable alternative to pelvic lymphadenectomy in early-stage cervical cancer. It is therefore imperative that centres without prior experience are able to successfully implement the procedure. The objectives of the current study were to (1) describe the process of implementing an SLN biopsy program with a novel peer mentorship component and (2) assess post-program quality improvement metrics, including SLN detection rate (DR) and diagnostic parameters...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28727125/usefulness-of-saline-infusion-sonohysterography-and-feeding-artery-imaging-in-endometrial-polyp-diagnosis
#8
Marcin Anioł, Grażyna Dec, Katarzyna Wojda, Piotr Sieroszewski
OBJECTIVES: The aim of this study was to assess the usefulness of sonohysterography with feeding artery visualization using transvaginal sonography to diagnose endometrial polyps. MATERIAL AND METHODS: We conducted an observational study of 60 perimenopausal patients referred to the Department of Fetal Medicine and Gynaecology, Medical University of Lodz with abnormal uterine bleeding or suspicion of endometrial pathology based on sonography scan. In all 60 patients transvaginal sonography scan showed a possibility of an endometrial polyp...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28724743/improving-the-healthcare-response-to-domestic-violence-and-abuse-in-sexual-health-clinics-feasibility-study-of-a-training-support-and-referral-intervention
#9
Alex Hardip Sohal, Neha Pathak, Sarah Blake, Vanessa Apea, Judith Berry, Jayne Bailey, Chris Griffiths, Gene Feder
OBJECTIVES: Sexual health and gynaecological problems are the most consistent and largest physical health differences between abused and non-abused female populations. Sexual health services are well placed to identify and support patients experiencing domestic violence and abuse (DVA). Most sexual health professionals have had minimal DVA training despite English National Institute for Health and Care Excellence recommendations. We sought to determine the feasibility of an evidence-based complex DVA training intervention in female sexual health walk-in services (IRIS ADViSE: Identification and Referral to Improve Safety whilst Assessing Domestic Violence in Sexual Health Environments)...
July 19, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28722774/-promoting-continuity-of-care-specialist-nurses-role-experiences-in-gynaecological-oncology-a-qualitative-study
#10
Andrea Kobleder, Hanna Mayer, Larissa Gehrig, Beate Senn
AIMS AND OBJECTIVES: To investigate the experiences of specialist nurses in Switzerland concerning their role of caring for women with gynaecological cancer. BACKGROUND: Women with gynaecological cancer often face complex situations, which require an integrative and quality-assured approach by the healthcare system. Specialist nurses can play an important role in supporting these patients. However, in countries where the role of specialist nurses is at a developmental stage, their role lacks clarity...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28721180/adenomyosis-back-to-the-future
#11
Z Ferraz, N Nogueira-Martins, F Nogueira-Martins
Adenomyosis is a benign invasion of endometrium into the myometrium. It produces a diffusely enlarged uterus and predominantly affects women in the late reproductive age. It has recently been associated with a negative impact on female fertility. Diagnosis is challenging because nonspecific symptoms can be present. However, it is asymptomatic in the majority of women. Medical treatment with GnRH agonist seems to be promising, particularly in subfertile women. A retrospective study was performed (182 patients) by examination of histopathological results with "adenomyosis" between January/2013 and September/2016...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28721179/early-and-late-onset-complications-of-gynaecologic-surgery-a-multimodality-imaging-approach
#12
REVIEW
I De Blasis, V Vinci, M E Sergi, F Capozza, M Saldari, F Moro, M C Moruzzi, A C Testa, L Manganaro
The role of imaging after surgery is pivotal to drive clinical management of early and/or late onset complications. Most frequently used imaging technique after pelvic surgery is Ultrasound (US), Magnetic Resonance Imaging (MRI) and Computed Tomography (CT). While Ultrasound is a standard procedure, using grey scale and/or colour Doppler evaluation, MRI and CT scan protocols should be derived on the basis of the specific indication of the exam. Correct evaluation of female pelvis after gynaecologic surgery, having in mind the most frequent complications, is based on the correct use of the instruments and on the experience of the examiner, who should be aware of the history of the patient, type of surgery and clinical symptoms for which the exam is required; the clinician should be aware of the possibilities and limits of the different techniques, in order to choose the most appropriate imaging modality and promptly make a correct diagnosis...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28719921/-patient-s-autonomy-and-information-in-psycho-oncology-computer-based-distress-screening-for-an-interactive-treatment-planning-epos-react
#13
Norbert Schäffeler, Jana Sedelmaier, Hannah Möhrer, Katrin Ziser, Johanna Ringwald, Martin Wickert, Sara Brucker, Florian Junne, Stephan Zipfel, Martin Teufel
To identify distressed patients in oncology using screening questionnaires is quite challenging in clinical routine. Up to now there is no evidence based recommendation which instrument is most suitable and how to put a screening to practice. Using computer based screening tools offers the possibility to automatically analyse patient's data, inform psycho-oncological and medical staff about the results, and use reactive questionnaires. Studies on how to empower patients in decision making in psycho-oncology are rare...
July 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718942/the-shift-toward-neo-adjuvant-chemotherapy-and-interval-debulking-surgery-for-management-of-advanced-ovarian-and-related-cancers-in-a-population-based-setting-impact-on-clinical-outcomes
#14
James L Nicklin, Shaun McGrath, Lee Tripcony, Andrea Garrett, Russell Land, Amy Tang, Lewis Perrin, Naven Chetty, Nisha Jagasia, Alex J Crandon, Marcelo Nascimento, Graeme Walker, Karen Sanday, Andreas Obermair
OBJECTIVES: The aim of this study was to determine the proportion of patients with advanced ovarian and related cancers (EOC+RC), treated with neoadjuvant chemotherapy and interval debulking surgery (NACT - IDS), and to determine if there was any relationship with optimal cytoreduction rates and overall survival (OS) in a state-wide gynaecologic oncology service over time. METHODS: A retrospective review was undertaken using a population-based database of patients with stages 3 and 4 EOC+RC treated from 1982 till 2013 at the Queensland Centre for Gynaecological Cancer (QCGC)...
July 18, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28718605/-when-sex-hurts-the-couple-the-case-of-endometriosis
#15
Stas Shabanov, Jean-Marie Wenger, Stéphanie Seidler, Mylène Bolmont, Francesco Bianchi-Demicheli, Nicola Pluchino
Sexual health is a critical aspect of quality of life and is also influenced by medical conditions and health care interventions, particularly when gynaecological disorders are involved. Dyspareunia is a common symptom of endometriosis, a cause of personal distress and a main raison for seeking treatment. Endometriosis negatively affects different domains of sexual function and specific biopsychological variables (chronic pain, recurrence, infertility) may further worsen quality of sexual function and relationship...
March 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28718600/-the-introduction-of-sexuality-during-gynaecological-consultation
#16
Angélick Schweizer
Many health organisms recommended to gynaecologists to actively address sexuality issues during consultation. However, physicians do not take systematically sexual history from their patients into account. The objective of this paper is to examine, on the basis of current knowledge and, more specifically on a Swiss study, gynaecologists' perceived obstacles and also patients' expectations with regard to sexuality issues. Findings highlighted a lack of training in sexology within medical programs. Moreover, it emphasized important mismatches on perceptions between gynaecologists and patients concerning the gynaecologist's role ; intimacy and even on the way of introducing sexuality topics...
March 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28718242/ectopic-pregnancy-with-tubal-rupture-an-analysis-of-80-cases
#17
Sana Ashfaq, Sadia Sultan, Safia Aziz, Marium Mohammed Irfan, Miray Hasan, Afshan Siddique
BACKGROUND: Ectopic pregnancy (EP) is a major problem in obstetrics as there is evidence of increasing incidence throughout the world. It is an important cause of maternal morbidity and mortality. In Pakistan, the care seeking behaviour among female is limited that makes female vulnerable to die due to complication of ectopic pregnancy. The aim of this study is to determine the frequency of tubal rupture in ectopic pregnancy in Pakistani patients. METHODS: In this crosssectional study data pertaining to age, gestational age, parity and duration of presenting symptoms were collected and analysed...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717396/intraoperative-radiotherapy-review-of-techniques-and-results
#18
REVIEW
Avinash Pilar, Meetakshi Gupta, Sarbani Ghosh Laskar, Siddhartha Laskar
Intraoperative radiotherapy (IORT) is a technique that involves precise delivery of a large dose of ionising radiation to the tumour or tumour bed during surgery. Direct visualisation of the tumour bed and ability to space out the normal tissues from the tumour bed allows maximisation of the dose to the tumour while minimising the dose to normal tissues. This results in an improved therapeutic ratio with IORT. Although it was introduced in the 1960s, it has seen a resurgence of popularity with the introduction of self-shielding mobile linear accelerators and low-kV IORT devices, which by eliminating the logistical issues of transport of the patient during surgery for radiotherapy or building a shielded operating room, has enabled its wider use in the community...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28712189/maternal-mortality-in-pakistan-is-there-any-metamorphosis-towards-betterment
#19
Nusrat Nisar, Razia Mustafa Abbasi, Shehla Raza Chana, Noushaba Rizwan, Razia Badar
BACKGROUND: Every year more than half million mother die due to pregnancy related preventable causes like haemorrhage, hypertensive disorders, sepsis, and obstructed labour and unsafe abortion. Among these deaths 99% occur in developing countries. The study was conducted to assess the maternal death rate and to analyse its trends over a period of 20 years in tertiary care hospital in Sindh Province Pakistan. METHODS: A retrospective analysis of maternal mortality records were carried out for a period of 20 years from 1986-1995 and 2011-2015 at the Department of Obstetrics and gynaecology Liaquat University of Medical and Health Sciences Hyderabad Sindh Pakistan...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28712177/analysis-of-two-years-cases-of-ectopic-pregnancy
#20
Ansa Islam, Aneesa Fawad, Azmat Ali Shah, Humaira Jadoon, Iram Sarwar, Aziz-Un-Nisa Abbasi
BACKGROUND: Ectopic pregnancy is the leading cause of pregnancy related deaths in the first trimester. The aim of this study was to evaluate the frequency of risk factors, clinical presentation, diagnostic methods and site of ectopic pregnancy. METHODS: This descriptive cross sectional study was conducted in Gynaecology and Obstetrical Unit-A of Ayub Teaching Hospital Abbottabad from 1st October 2013 to 31st October 2015. All women diagnosed with ectopic pregnancy were included in the study...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
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