Sidonie Lambert-Niclot, Basma Abdi, Jonathan Bellet, Djeneba Fofana, Pierre De Truchis, Karine Amat, Jean-Claude Alvarez, Laure Surgers, Clothilde Allavena, Olivia Zaegell-Faucher, Philippe Morlat, Romain Palich, Séverine Gibowski, Dominique Costagliola, Pierre-Marie Girard, Roland Landman, Lambert Assoumou, Laurence Morand-Joubert
BACKGROUND: In a 4 days/week (4/7 days) maintenance strategy (ANRS-170 QUATUOR trial), the virological impact of an intermittent strategy was assessed by ultrasensitive virological analyses of reservoirs and resistance. METHODS: HIV-1 total DNA, ultra-sensitive plasma viral load (USpVL) and semen VL were measured in the first 121 participants. Sanger and ultra-deep sequencing (UDS) were performed on the HIV-1 genome (Illumina technology) according to the ANRS consensus...
April 27, 2023: Journal of Antimicrobial Chemotherapy