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Hemocoagulase

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https://www.readbyqxmd.com/read/28906404/ticagrelor-induced-life-threatening-bleeding-via-the-cyclosporine-mediated-drug-interaction-a-case-report
#1
Chi Zhang, Long Shen, Min Cui, Xiaoyan Liu, Zhichun Gu
RATIONALE: Ticagrelor has become one of the first-line antiplatelet agents in acute coronary syndrome (ACS) patients recommend by the guideline due to its more potent and predictable antiplatelet effect. However, bleeding is still a severe drug adverse reaction of ticagrelor therapy. We report a first case on ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction. PATIENT CONCERNS: A 58-year-old Chinese male who received cyclosporine 200 mg daily 5 years after renal transplantation...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28545858/hemocoagulase-combined-with-microbubble-enhanced-ultrasound-cavitation-for-augmented-ablation-of-microvasculature-in-rabbit-vx2-liver-tumors
#2
Qian Yang, Peng Tang, Guangbin He, Shuping Ge, Liwen Liu, Xiaodong Zhou
We investigated a new method for combining microbubble-enhanced ultrasound cavitation (MEUC) with hemocoagulase (HC) atrox. Our goal was to induce embolic effects in the vasculature and combine these with an anti-angiogenic treatment strategy. Fourteen days after being implanted with a single slice of the liver VX2 tumor, rabbits were randomly divided into five groups: (i) a control group injected intra-venously with saline using a micropump; (ii) a group given only an injection of HC; (iii) a group treated only with ultrasound cavitation; (iv) a group treated with MEUC; (v) a group treated with MEUC + HC...
May 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28524041/-effect-of-endotracheal-tube-with-subglottic-suction-line-to-stop-tracheostomy-bleeding-in-critical-patients
#3
Qiaoke Li
OBJECTIVE: To observe the effect of endotracheal tube with subglottic suction line on tracheostomy bleeding in critical patients. METHODS: This procedure was utilized for 35 critical patients with tracheostomy bleeding. With the help of bronchoscope, the endotracheal tube with subglottic suction line was inserted during tracheostomy to 0.5-1.0 cm above the carina. Then aerocyst of the tube was inflated, vacuum was set up for continuous suction via suction port, and hemocoagulase was injected to the opening of tracheostomy...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28483015/hemostatic-effect-of-hemocoagulase-agkistrodon-on-surgical-wound-in-breast-cancer-surgery
#4
Xu Lu, Xin Yang, Mingwei Zhu, Bin Hua, Xiaojuan Niu, Wenzheng Xiao, Junmin Wei
Objective To evaluate the hemostatic effect of hemocoagulase agkistrodon on surgical wound in breast cancer surgery. Methods Totally 60 patients undergoing breast cancer surgery were enrolled in this prospective,randomized,double-blinded,and controlled study. All the patients met the inclusion and exclusion criteria and signed the informed consent. Hemocoagulase agkistrodon (2 U) was injected 20 minutes before surgery and 4 and 24 hours after surgery in the intervention group (n=30),whereas normal saline was used instead in the control group (n=30)...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28325889/hypofibrinogenemia-caused-by-hemocoagulase-after-colon-polyps-excision
#5
Hai-Bo Zhou
BACKGROUND In patients with large colon polyps, late-onset bleeding may be more likely to occur because of the larger cutting surface. In these patients, hemostatic agents may be applied to prevent the late-onset bleeding. A total of 7 patients developed hypofibrinogenemia caused by hemocoagulase following excision of colon polyps in our center from November to December 2015. CASE REPORT Seven patients underwent excision of colon polyps in our center from November to December 2015. The cutting face was large in these patients after surgery; therefore, hemocoagulase was used to prevent potential late-onset bleeding...
March 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28238301/the-impact-of-hemocoagulase-for-improvement-of-coagulation-and-reduction-of-bleeding-in-fracture-related-hip-hemiarthroplasty-geriatric-patients-a-prospective-single-blinded-randomized-controlled-study
#6
Meiguang Qiu, Xuming Zhang, Hongru Cai, Zhixian Xu, Hao Lin
BACKGROUND: Uncontrolled bleeding is associated with poor outcomes and mortality in geriatric patients undergoing hemiarthroplasty. Hemocoagulase agkistrodon is a hemocoagulative, anti-hemorrhagic enzyme complex from Deinagkistrodon acutus snake venom. This study aimed to investigate the efficacy of hemocoagulase agkistrodon on coagulation and bleeding outcomes in fracture-related hemiarthroplasty. PATIENTS AND METHODS: This was a prospective, single-blinded, randomized controlled trial carried out between October 2013 and September 2014 in 96 geriatric patients undergoing hemiarthroplasty for unilateral femoral neck fracture...
November 27, 2016: Injury
https://www.readbyqxmd.com/read/27433096/hemostatic-effect-of-topical-hemocoagulase-spray-in-digestive-endoscopy
#7
RANDOMIZED CONTROLLED TRIAL
Tao Wang, Dan-Na Wang, Wen-Tian Liu, Zhong-Qing Zheng, Xin Chen, Wei-Li Fang, Shu Li, Li Liang, Bang-Mao Wang
AIM: To evaluate the hemostatic effect of topical hemocoagulase spray in digestive endoscopy. METHODS: Eighty-nine patients who developed oozing bleeding during endoscopic treatment from September 2014 to October 2014 at Center for Digestive Endoscopy, Tianjin Medical University General Hospital were randomly divided into either a study group (n = 39) or a control group (n = 50). The study group was given topical hemocoagulase spray intraoperatively, while the control group was given traditional 8% norepinephrine spray...
July 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27228751/-study-on-raman-spectra-of-some-clinical-medicine
#8
He Dong, Chuan Liu, Chang-Jian Dai
Aiming at the shortage of the Raman spectra of drugs and the current situation of drug testing, we have applied Raman spectroscopic technique to several kinds of medicine, such as antibiotics, antihistamine, hemocoagulase and antiemetics. The spectral properties for the samples with high Raman activity are investigated by observing their Raman spectra to yield the shift, intensity, and line width of the Raman peaks, as well as the line shape of Raman envelope. For those samples with weak Raman activity or complex structures that are hard to be identified, we have also made some tentative measurements or raise some suggestions for future measurement...
January 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/27197462/-hypofibrinogenemia-caused-by-hemocoagulase-after-endoscopic-sinus-surgery-a-case-report
#9
Caixia Zhang, Yangyun Liu, Gengxun Liu
A 61 year-old male patient, plasma fibrinogen level was 2.98 g/L, endoscopic sinus surgery was performed under general anesthesia for polypoid of uncinate process with mycotic maxillary sinusitis. Hemocoagulase were given in pre- and post-operative for treatment. The patient was found postoperative drain blood continuously since 3 days after surgery, when the dose of hemocoagulase reach 26 KU, and fibrinogen determined in Plasma was 0.48 g/L. Coagulation returned to normal and nasal bleeding stopped after discontinuation of the hemocoagulase and supplement with fibrinogen...
January 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/26658430/risk-factors-for-postoperative-fibrinogen-deficiency-after-surgical-removal-of-intracranial-tumors
#10
Naili Wei, Yanfei Jia, Xiu Wang, Yinian Zhang, Guoqiang Yuan, Baotian Zhao, Yao Wang, Kai Zhang, Xinding Zhang, Yawen Pan, Jianguo Zhang
Higher levels of fibrinogen, a critical element in hemostasis, are associated with increased postoperative survival rates, especially for patients with massive operative blood loss. Fibrinogen deficiency after surgical management of intracranial tumors may result in postoperative intracranial bleeding and severely worsen patient outcomes. However, no previous studies have systematically identified factors associated with postoperative fibrinogen deficiency. In this study, we retrospectively analyzed data from patients who underwent surgical removal of intracranial tumors in Beijing Tiantan Hospital date from 1/1/2013to12/31/2013...
2015: PloS One
https://www.readbyqxmd.com/read/26636421/hemocoagulase-agkistrodon-induced-anaphylactic-shock-a-case-report-and-literature-review
#11
REVIEW
Yan-Yan Xu, Xu-Hui Ma, Shao-Jun Zhang
Hemocoagulase agkistrodon for injection is the national first-class new drug of China with good hemostatic function and safety for capillary hemorrhage in abdominal incision of surgical patients. Adverse drug reactions (ADRs) to hemocoagulase agkistrodon are rarely reported. In this paper, we describe a case of a 41-year-old woman who developed anaphylactic shock attributed to hemocoagulase agkistrodon before colon cancer surgery. Based on the Naranjo ADR probability score, a "probable" cause and effect relationship existed for this case...
February 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26225048/the-effects-of-topical-hemocoagulase-solution-on-the-healing-process-of-post-extraction-wounds-a-split-mouth-design
#12
Vandana Shenoy K, Mohan Baliga, Sumitha Mahajan, Ramesh K V
OBJECTIVES: To evaluate the effects of topical hemocoagulase on intra-oral extraction sockets and impact on the healing process as well as to produce a clinico-histological healing score. STUDY DESIGN: This prospective study compared two extraction sites in each subject. One site received topical hemocoagulase while other site did not receive it. Both the sites were chosen in the same patient and extraction was done at separate intervals. The biopsy was done on a random basis with the pathologist being blinded to the study...
September 2015: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/26064413/serious-anaphylactic-shock-induced-by-hemocoagulase-agkistrodon-during-anesthesia-in-a-5-year-old-child
#13
Ying-Yi Xu, Bi-Lian Li, Yu-Lin Jin, Zi-Xin Wang, Xing-Rong Song, Jin Ni
We report a case of serious anaphylactic shock in a 5-year-old child undergoing scheduled surgery blank space of a right femoral intramedullary nail removal. The boy had undergone right femoral elastic intramedullary nail fixation surgery 14 months prior, but had no history of allergies. Within 5 minutes of intravenous bonus injection of hemocoagulase agkistrodon (HCA) 1 unit, a widespread transient diffuse erythema was seen on the front of his chest. After 20 minutes, sudden, profound cardiovascular collapse occurred...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25007675/-a-double-blind-rct-of-the-hemostatic-effects-of-local-packing-of-nasopore-combined-with-hemocoagulase-injection-for-postoperative-management-of-fess
#14
RANDOMIZED CONTROLLED TRIAL
Jia Ren, Yilin Liu, Qiulin Li, Feng Liu, Junming Xian, Huimin An, Yafeng Liu, Shixi Liu
OBJECTIVE: To compare the hemostatic effects of local packing of Nasopore combined with hemocoagulase injection and local packing of Nasopore combined with saline injection for postoperative management of functional endoscopic sinus surgery by a double-blind, randomized control clinical trial. METHOD: Sixty-eight cases of chronic sinusitis needed functional endoscopic sinus surgery were randomly divided into the experimental group of 40 cases and control group of 28 cases, respectively...
April 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/24987614/topical-use-of-hemocoagulase-reptilase-a-simple-and-effective-way-of-managing-post-extraction-bleeding
#15
Samir A Joshi, Kiran S Gadre, Rajshekhar Halli, Ramanojam Shandilya
No abstract text is available yet for this article.
January 2014: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/24602733/-hypofibrinogenemia-caused-by-long-term-administration-of-hemocoagulase-three-cases-report-and-literature-review
#16
Zhaoyue Wang, Jianqin Li, Lijuan Cao, Ziqiang Yu, Xia Bai, Changgeng Ruan
OBJECTIVE: A first report of 3 patients who developed hypofibrinogenemia due to long-term administration of hemocoagulase. METHODS: The clinical data of three patients with hypofibrinogenemia due to long-term administration of hemocoagulase were analyzed, and the related literature was reviewed. RESULTS: Case 1, a two-year old girl, had liver traumatic rupture and then treated with massive transfusion and fibrinogen infusion in addition to intravenous recombinant factor VIIa (two times) and hemocoagulase (2 U/d)...
January 2014: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/24360185/-effects-of-batroxobin-and-electric-cauterization-on-vascular-remodeling-of-rabbit-with-a-removal-of-carotid-arterial-adventitia
#17
Yuan-cheng Hu, Sheng-yun Wan, Yan-qing Zhan, Dan-dan Qin, Yang Ding
OBJECTIVE: To explore the topical hemostatic effects of batroxobin (BX) and electric cauterization (EC) on capillary hemorrhage of rabbit with a removal of carotid arterial adventitia. METHODS: A total of 27 New Zealand rabbits were randomly divided into control, BX and EC groups. Each group received BX (2 kU/L), EC (power = 40 W) and saline for topical hemostasis after a removal of carotid arterial adventitia and blunt dissection. The animals were euthanized by 0, 14 and 28 d post-operation...
September 17, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/24228100/hemocoagulase-atrox-reduces-vascular-modeling-in-rabbit-carotid-artery-adventitia
#18
Sheng-Yun Wan, Yuan-Cheng Hu, Yan-Qing Zhan, Dan-Dan Qin, Yang Ding
OBJECTIVE: This study aimed to compare the effects of hemocoagulase atrox and cauterization hemostasis on intimal hyperplasia and explore the effect of hemocoagulase atrox on vascular modeling in rabbit carotid artery adventitia. METHODS: A total of 27 rabbits were randomly divided into 3 groups (0d, 14d, 28d). They were anaesthetized using an intramuscular injection of phenobarbital sodium (1 ml/kg). The left and right common carotid arteries were exposed and capillary hemorrhaged after blunt dissection of the adventitia layers of common carotid arteries...
2013: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/24171979/a-double-blind-study-on-the-efficacy-of-local-application-of-hemocoagulase-solution-in-wound-healing
#19
COMPARATIVE STUDY
Sachin Aslam, P G Francis, B H S Rao, M Ummar, J K Issac, R B Nair
AIM: The present double blind study has been designed to evaluate the efficacy of local application of hemocoagulase solution as compared to a placebo in wound healing following dental extraction. MATERIALS AND METHODS: A total of 20 patients who required dental extraction for orthodontic intervention were included. The hemocoagulase solution and a placebo were locally applied to the extraction sockets and the efficacy of the solution in terms of bleeding control, anti-inflammatory responses, its antiseptic properties and efficacy in wound healing were evaluated...
May 2013: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/23357044/determination-of-hemocoagulase-agkistrodon-in-a-pharmaceutical-preparation-by-high-performance-liquid-chromatography-with-pre-column-derivatization-and-fluorescence-detection
#20
Suyuan Cheng, Chaozhong Wang, Jing Li, Chenggang Liang, Fengshan Wang
Currently, there is no analytical method for the quantification of hemocoagulase agkistrodon (HCA) in pharmaceutical preparations. This study presents a pre-column derivatization method for the quantification of HCA, a compound extracted from the venom of Agkistrodon acutus, in a pharmaceutical preparation (trade name Suling). In the proposed method, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate was used to tag the HCA substrate, and the derivatives were analyzed by high-performance liquid chromatography with fluorescence detection...
July 2013: Journal of Chromatographic Science
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