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https://www.readbyqxmd.com/read/28182801/acute-kidney-injury-in-patients-treated-with-vancomycin-and-piperacillin-tazobactam-a-retrospective-cohort-analysis
#1
W Cliff Rutter, Donna R Burgess, Jeffery C Talbert, David S Burgess
BACKGROUND: Empiric antimicrobial therapy often consists of the combination of gram-positive coverage with vancomycin (VAN) and gram-negative coverage, specifically an antipseudomonal beta-lactam such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports show higher nephrotoxicity rates among patients treated with the combination of VAN and PTZ. OBJECTIVE: This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI) compared to VAN and PTZ monotherapies...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28182036/acute-kidney-injury-and-mortality-in-hematopoietic-stem-cell-transplantation-a-single-center-experience
#2
B Sehgal, P George, M J John, C Samuel
Hematopoietic stem cell transplant (HSCT) is a life-saving procedure for patients with several malignant and nonmalignant hematological disorders. Acute kidney injury (AKI) is a common complication after HSCT. The aim of the study was to identify the incidence and outcomes of AKI associated with HSCT in our center. Sixty-six HSCT recipients from October 2008 to March 2014 at Christian Medical College, Ludhiana, were followed up till July 31, 2014. RIFLE criteria utilizing serum creatinine was used to diagnose and stage AKI...
January 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28179898/metatranscriptomic-analysis-reveals-unexpectedly-diverse-microbial-metabolism-in-a-biogeochemical-hot-spot-in-an-alluvial-aquifer
#3
Talia N M Jewell, Ulas Karaoz, Markus Bill, Romy Chakraborty, Eoin L Brodie, Kenneth H Williams, Harry R Beller
Organic matter deposits in alluvial aquifers have been shown to result in the formation of naturally reduced zones (NRZs), which can modulate aquifer redox status and influence the speciation and mobility of metals, affecting groundwater geochemistry. In this study, we sought to better understand how natural organic matter fuels microbial communities within anoxic biogeochemical hot spots (NRZs) in a shallow alluvial aquifer at the Rifle (CO) site. We conducted a 20-day microcosm experiment in which NRZ sediments, which were enriched in buried woody plant material, served as the sole source of electron donors and microorganisms...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167560/nephrotoxicity-in-patients-with-and-without-cystic-fibrosis-treated-with-polymyxin-b-compared-to-colistin
#4
Ryan L Crass, W Cliff Rutter, Donna R Burgess, Craig A Martin, David S Burgess
Nephrotoxicity is the primary adverse effect of the polymyxins. The relative rates of toxicity between polymyxin B and colistin have not been fully elucidated, especially in patients with cystic fibrosis (CF). A retrospective cohort study of adults treated with polymyxin B or colistin for at least 48 hours was conducted. The primary endpoint was the incidence of kidney injury by RIFLE (i.e., Risk, Injury, Failure, Loss, End-Stage Renal Disease) criteria. Risk factors for kidney injury were evaluated using multivariate Cox regression...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28149246/acute-kidney-injury-in-critically-burned-patients-resuscitated-with-a-protocol-that-includes-low-doses-of-hydroxyethyl-starch
#5
M Sánchez-Sánchez, A Garcia-de-Lorenzo, L Cachafeiro, E Herrero, M J Asensio, A Agrifoglio, E Flores, B Estebanez, P Extremera, C Iglesias, J R Martinez
Acute kidney injury (AKI) is an important complication in burn patients. Recently, it has been recommended that hydroxyethyl starch (HES) be avoided in burn patients because it increases the incidence of AKI. Our purpose was to study incidence of AKI in critically ill burn patients resuscitated with Ringer's solution and supplements of HES. We conducted an observational study of 165 patients admitted to the critical care burn unit (with 30 ± 15% TBSA burned). The main outcome measures were incidence of AKI, contributions of colloids and crystalloids, various severity scores, comorbidities, complications and mortality...
September 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28143505/fluid-overload-is-an-independent-risk-factor-for-acute-kidney-injury-in-critically-ill-patients-results-of-a-cohort-study
#6
Nawal Salahuddin, Mustafa Sammani, Ammar Hamdan, Mini Joseph, Yasir Al-Nemary, Rawan Alquaiz, Ranim Dahli, Khalid Maghrabi
BACKGROUND: Acute Kidney injury (AKI) is common and increases mortality in the intensive care unit (ICU). We carried out this study to explore whether fluid overload is an independent risk factor for AKI. METHODS: Single-center prospective, observational study. Consecutively admitted, ICU patients were followed for development of AKI. Intravenous fluid volumes, daily fluid balances were measured, hourly urine volumes, daily creatinine levels were recorded. RESULTS: Three hundred thirty nine patients were included; AKI developed in 141 (41...
February 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28142264/annals-express-neutrophil-gelatinase-associated-lipocalin-is-a-better-biomarker-than-cystatin-c-for-predicting-imminent-acute-kidney-injury-in-critically-ill-patients
#7
Itir Yegenaga, Fatih Kamis, Canan Baydemir, Elizade Erdem, Koray Celebi, Necmi Eren, Nur Baykara
AIMS: The prevention of acute kidney injury (AKI) can be lifesaving for intensive care unit (ICU) patients. However, conventional methods are not sufficient for predicting the risk for approaching AKI. In this study, the promising biomarker NGAL(neutrophil gelatinase-associated lipocalin) was compared to CysC (Cystatin C ) for indicating risk of future AKI. METHODS: One hundred eighty-three adult patients without chronic kidney disease or renal replacement therapy were included in this study...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28142133/perioperative-hemodynamic-instability-and-fluid-overload-are-associated-with-increasing-acute-kidney-injury-severity-and-worse-outcome-after-cardiac-surgery
#8
Anja Haase-Fielitz, Michael Haase, Rinaldo Bellomo, Paolo Calzavacca, Anke Spura, Hassina Baraki, Ingo Kutschka, Christian Albert
PURPOSE: The study aimed to investigate patients' characteristics, fluid and hemodynamic management, and outcomes according to the severity of cardiac surgery-associated acute kidney injury (CSA-AKI). METHODS: In a single-center, prospective cohort study, we enrolled 282 adult cardiac surgical patients. In a secondary analysis, we assessed preoperative patients' characteristics, physiological variables, and medication for intra- and postoperative fluid and hemodynamic management and outcomes according to CSA-AKI stages by the Renal risk, Injury, Failure, Loss, End-stage renal disease (RIFLE) classification...
January 31, 2017: Blood Purification
https://www.readbyqxmd.com/read/28128096/validation-of-a-colistin-plasma-concentration-breakpoint-as-a-predictor-of-nephrotoxicity-in-patients-treated-with-colistin-methanesulfonate
#9
Juan P Horcajada, Luisa Sorlí, Sonia Luque, Natividad Benito, Concepción Segura, Nuria Campillo, Milagro Montero, Erika Esteve, Beatriz Mirelis, Virginia Pomar, Jordi Cuquet, Carmina Martí, Pau Garro, Santiago Grau
Nephrotoxicity limits the effective use of colistin for the treatment of multidrug-resistant Gram-negative bacteria (MDR-GNB) infections. We previously defined a steady-state colistin plasma concentration (Css) of 2.42 mg/L that predicted nephrotoxicity at end of treatment (EOT). The objective of this study was to validate this breakpoint in a prospective cohort. This was a multicentre, prospective, observational study conducted at three hospitals with a cohort of patients treated for MDR-GNB infection with colistin methanesulfonate from September 2011 until January 2015...
December 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28126256/abnormal-trajectory-of-an-air-rifle-bullet-in-the-body-an-atypical-case
#10
Mustafa Yilmaz, Suha Ertugrul, Celal Selcuk Unal, Emre Kubat, Serhat Koyuncu
No abstract text is available yet for this article.
January 23, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28124458/hepatic-ischemia-reperfusion-injury-associates-with-acute-kidney-injury-in-liver-transplantation-prospective-cohort-study
#11
Ina Jochmans, Nicolas Meurisse, Arne Neirynck, Marleen Verhaegen, Diethard Monbaliu, Jacques Pirenne
: Solid clinical prospective studies investigating the association between hepatic ischemia reperfusion injury and acute kidney injury after liver transplantation are missing. Hepatic ischemia reperfusion injury -reflected by transaminase release- induces acute kidney injury in rodents and retrospective studies suggest a similar association in man. This prospective cohort study determined risk factors for acute kidney injury in 80 adult liver-only recipients. Acute kidney injury -defined by RIFLE-criteria- developed in 21 (26%) recipients at 12 hours postreperfusion [inter quartile range: 6 hours-postoperative day 1]; 13 progressed from "Risk" to "Injury"; 5 to "Failure"...
January 25, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28116657/letters-to-the-editor-in-response-to-studies-of-guns-in-the-home-and-homicide-and-suicide
#12
REVIEW
Douglas J Wiebe, Kalen Flynn, Charles C Branas
BACKGROUND: Letters to the editor are an important venue for scientific discussion and ensuring accountability of authors and editors. We investigated the content and tone of letters to the editor published in response to research on having a firearm in the home as it relates to homicide and suicide. METHODS: A recent meta-analysis found 16 analytic studies of household firearm access and homicide and suicide. We audited the letters to the editor emanating from those 16 articles...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28093933/acute-kidney-injury-in-idiopathic-nephrotic-syndrome-of-childhood-is-a-major-risk-factor-for-the-development-of-chronic-kidney-disease
#13
Afshan Yaseen, Vina Tresa, Ali Asghar Lanewala, Seema Hashmi, Irshad Ali, Sabeeta Khatri, Muhammed Mubarak
BACKGROUND: Acute kidney injury (AKI) is an important complication of idiopathic nephrotic syndrome (INS) and is associated with adverse outcomes, especially the development of chronic kidney disease (CKD). We aimed to determine the clinical profile of children with INS who developed AKI and its short-term outcome. MATERIAL AND METHODS: This prospective study was conducted from March 2014 to October 2015. A total of 119 children of INS (age: 2-18 years) fulfilling the pediatric RIFLE criteria for the diagnosis of AKI were enrolled and followed up for 3 months to determine the outcome...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28089222/-etiology-and-prognosis-of-the-eye-traumas-by-war-weapons-in-the-senegalese-army
#14
S M Seck, M Diakhaté, M N Ndiaye Sow, M Dieng, G Agboton, N N Guèye
INTRODUCTION: The aim of this work is to identify the main weapons causing eye injuries during the campaigns of the Senegalese army in the south of the country, as well as the prognosis of these traumas. PATIENTS AND METHODS: This study is retrospective and concerns soldiers wounded by the weapons of war during the exercise of their mission within the Senegalese armed forces of 1991 in 2005. They are mainly soldiers affected in the south of the country during a war, clashes with the rebels or in Guinea-Bissau during operation Gabou in 1998...
January 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28079263/comparison-of-rates-of-nephrotoxicity-associated-with-vancomycin-in-combination-with-piperacillin-tazobactam-administered-as-an-extended-versus-standard-infusion
#15
Mariam Mousavi, Tanya Zapolskaya, Marco R Scipione, Eddie Louie, John Papadopoulos, Yanina Dubrovskaya
STUDY OBJECTIVE: Despite recent reports of relatively high rates (16-37%) of acute kidney injury (AKI) in patients receiving the combination of intravenous piperacillin-tazobactam (PTZ) and vancomycin, data are limited evaluating the impact of PTZ infusion strategy on the occurrence of nephrotoxicity. The objective of this study was to compare the rates of nephrotoxicity in patients receiving vancomycin in combination with PTZ administered as an extended infusion (EI) versus a standard infusion (SI)...
January 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28072758/how-to-escape-the-immune-response-what-tumours-have-to-teach-to-transplant-immunologists
#16
Guillaume Claisse, Olivier Thaunat, Christiane Mousson, Kathryn J Wood, Gérard Rifle, Christophe Mariat
Recent progress in deciphering the mechanisms underlying the concepts of tumor immunosurveillance and immunoevasion has opened new opportunities for the development of effective anti-tumor therapies. Transplant physicians and immunologists have much to learn from those direct clinical translations of basic science. The 2016 Beaune Seminar in Transplant research brought together researchers from both fields to explore and discuss significant advances in cancer biology, immunotherapies and their potential impacts for the management of cancer in transplant recipients...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28054900/urine-output-during-cardiopulmonary-bypass-predicts-acute-kidney-injury-after-coronary-artery-bypass-grafting
#17
Mehmet Yilmaz, Rezan Aksoy, Vildan Kilic Yilmaz, Canan Balci, Cagri Duzyol, Atike Tekeli Kunt
OBJECTIVE: This study evaluated the relationship between the amount of urinary output during cardiopulmonary bypass and acute kidney injury in the postoperative period of coronary artery bypass grafting. METHODS: Two hundred patients with normal preoperative serum creatinine levels, operated on with isolated CABG between 2012-2014 were investigated retrospectively. The RIFLE (Risk, injury, failure, loss of function, and end-stage renal disease) risk scores were calculated for each patient in the third postoperative day...
16, 2016: Heart Surgery Forum
https://www.readbyqxmd.com/read/28049899/the-incidence-of-cisplatin-induced-hypomagnesemia-in-cervical-cancer-patients-receiving-cisplatin-alone
#18
Yoshihiro Yamamoto, Kazushi Watanabe, Hiroshi Matsushita, Ikuto Tsukiyama, Katsuhiko Matsuura, Akihiko Wakatsuki
 Hypomagnesemia is one side effect in patients receiving cisplatin. However, there are few reports of cisplatin-induced hypomagnesemia in Japan. We retrospectively investigated the incidence of hypomagnesemia and nephrotoxicity in patients undergoing radiation therapy who were treated with cisplatin alone (dosage: 40 mg/m(2), administration interval: 1 week) for cervical cancer. Thirty-two patients undergoing radiation therapy who received cisplatin alone for cervical cancer between January 2012 and May 2016 at Aichi Medical University Hospital were included...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28018150/frequency-of-and-risk-factors-for-acute-kidney-injury-associated-with-vancomycin-use-in-the-pediatric-intensive-care-unit
#19
Sarah Bonazza, Lauren C Bresee, Timothy Kraft, B Catherine Ross, Deonne Dersch-Mills
BACKGROUND: Published information evaluating frequency of and risk factors for vancomycin-induced acute kidney injury (AKI) in the pediatric intensive care unit (PICU) population is conflicting. OBJECTIVES: The primary objective was to describe the proportion of our PICU patients who developed AKI with intravenous (IV) vancomycin. The secondary objective was to describe the associated potential risk factors. METHODS: Pediatric patients (0-18 years) who received their first IV vancomycin dose in the PICU were evaluated in this retrospective chart review...
November 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27991471/cigarette-and-snus-modified-association-between-unprotected-exposure-to-noise-from-hunting-rifle-caliber-weapons-and-high-frequency-hearing-loss-a-cross-sectional-study-among-swedish-hunters
#20
Louise Honeth, Peter Ström, Alexander Ploner, Dan Bagger-Sjöbäck, Ulf Rosenhall, Olof Nyrén
AIM: To investigate in this cross-sectional study among Swedish hunters if tobacco use modifies the previously observed association, expressed as prevalence ratio (PR), between unprotected exposure to impulse noise from hunting rifle caliber (HRC) weapons and high-frequency hearing impairment (HFHI). SETTINGS AND DESIGN: A nationwide cross-sectional epidemiologic study was conducted among Swedish sport hunters in 2012. MATERIALS AND METHODS: The study was Internet-based and consisted of a questionnaire and an Internet-based audiometry test...
November 2016: Noise & Health
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