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https://www.readbyqxmd.com/read/29759124/the-seronegative-spondyloarthropathies
#1
REVIEW
Ayyappa S Duba, Stephanie D Mathew
The seronegative spondyloarthropathies are a group of five diseases characterized by inflammatory oligoarticular arthritis, enthesitis, and axial involvement. They have an increased incidence of the HLA-B27 gene. They are commonly associated with extra-articular features including involvement of the skin, eyes, and gastrointestinal tract. Early recognition and referral are key to limit disability, and comanagement with primary care and rheumatology offers the best outcomes.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29740454/determination-of-autoantibody-isotypes-increases-the-sensitivity-of-serodiagnostics-in-rheumatoid-arthritis
#2
Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Sascha Swiniarski, Thomas Horn, Helmuth Haslacher, Stephan Blüml, Josef Smolen, Günter Steiner
Anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are the most commonly used diagnostic markers of rheumatoid arthritis (RA). These antibodies are predominantly of the immunoglobulin (Ig) M (RF) or IgG (ACPA) isotype. Other subtypes of both antibodies-particularly IgA isotypes and other autoantibodies-such as RA33 antibodies-have been repeatedly reported but their diagnostic value has still not been fully elucidated. Here, we investigated the prevalence of IgA, IgG, and IgM subtypes of RF, ACPA, and RA33 antibodies in patients with RA...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29733234/glycosylation-of-random-igg-distinguishes-seropositive-and-seronegative-rheumatoid-arthritis
#3
I Magorivska, B Döncző, T Dumych, A Karmash, M Boichuk, K Hychka, M Mihalj, M Szabó, E Csánky, J Rech, A Guttman, S G Vari, R Bilyy
The N-glycosylation of human immunoglobulins, especially IgGs, plays a critical role in determining affinity of IgGs towards their effector (pro- and anti-inflammatory) receptors. However, it is still not clear whether altered glycosylation is involved in only antibody-dependent disorders like seropositive rheumatoid arthritis (RA) or also in pathologies with similar clinical manifestations, but no specific autoantibodies like seronegative RA. The clarification of that uncertainty was the aim of the current study...
May 7, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29709007/chikungunya-virus-infection-in-aruba-diagnosis-clinical-features-and-predictors-of-post-chikungunya-chronic-polyarthralgia
#4
Ralph Huits, Jaclyn De Kort, Riemsdijk Van Den Berg, Luis Chong, Achilleas Tsoumanis, Kaat Eggermont, Koen Bartholomeeusen, Kevin K Ariën, Jan Jacobs, Marjan Van Esbroeck, Emmanuel Bottieau, Lieselotte Cnops
BACKGROUND: Chikungunya virus (CHIKV) emerged in Aruba for the first time in 2014. We studied the clinical presentation of acute CHIKV infection and the contribution of serologic and molecular assays to its diagnosis. In a cohort of confirmed CHIKV cases, we analysed the frequency, duration and predictors of post-chikungunya chronic polyarthralgia (pCHIK-CPA), defined as joint pains lasting longer than 6 weeks or longer than 1 year. METHODOLOGY: Patient sera obtained within 10 days of symptom onset were tested for CHIKV, using an indirect immunofluorescence test for the detection of CHIKV-specific Immunoglobulin M (IgM) and post-hoc, by reverse-transcription polymerase chain reaction (RT-PCR)...
2018: PloS One
https://www.readbyqxmd.com/read/29684943/the-diagnostic-implications-of-two-cases-of-known-rheumatoid-arthritis-from-the-cal-milano-cemetery-skeletal-collection
#5
Lucie Biehler-Gomez, Cristina Cattaneo
Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#6
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29674399/liver-chemistry-abnormalities-and-leg-oedema-in-rheumatoid-arthritis
#7
Eva Marianne van Soest, Anho Liem, Jende van Zeben
A 66-year-old man with seronegative, erosive rheumatoid arthritis for 12 years presented with malaise, elevated alkaline phosphatase and gamma-glutamyl transferase, and leg oedema. He subsequently developed ascites. No liver pathology was found, but cardiac analysis including right heart catheterisation revealed constrictive pericarditis. Rheumatoid constrictive pericarditis is a rare condition, but, despite current effective treatment for rheumatoid arthritis, still occurs. Diagnostic delay is frequent. Although mortality of the intervention is high, pericardiectomy is needed for most patients...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29672807/imaging-to-differentiate-the-various-forms-of-seronegative-arthritis
#8
Iris Eshed, Kay-Geert A Hermann, Anna Zejden, Iwona Sudoł-Szopińska
Spondyloarthritis (SpA) is a group of diseases characterized by back pain, spinal inflammation, human leukocyte antigen-B27 positivity, and peripheral findings such as dactylitis, enthesitis, and uveitis. It includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated SpA. The role of imaging in the diagnosis, management, and follow-up of patients with SpA has become dramatically more important with the introduction of new therapies such as tumor necrosis factor-α inhibitors...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29657830/conversion-to-seronegative-status-after-abatacept-treatment-in-patients-with-early-and-poor-prognostic-rheumatoid-arthritis-is-associated-with-better-radiographic-outcomes-and-sustained-remission-post-hoc-analysis-of-the-agree-study
#9
Diahann T S L Jansen, Paul Emery, Josef S Smolen, Rene Westhovens, Manuela Le Bars, Sean E Connolly, June Ye, René E M Toes, Tom W J Huizinga
Objective: To evaluate the effects of the T-cell costimulation blocker abatacept on anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) in early rheumatoid arthritis (RA), and associations between changes in serological status and clinical response. Methods: Post hoc analysis of the phase III AGREE study in methotrexate (MTX)-naïve patients with early RA and poor prognostic factors. Patients were randomised to abatacept (~10 mg/kg intravenously according to weight range) or placebo, plus MTX over 12 months followed by open-label abatacept plus MTX for 12 months...
2018: RMD Open
https://www.readbyqxmd.com/read/29624625/clinical-management-of-seronegative-and-seropositive-rheumatoid-arthritis-a-comparative-study
#10
Sang-Tae Choi, Kwang-Hoon Lee
Both rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACPA) are associated with poor radiologic outcomes in patients with rheumatoid arthritis (RA). In general, RA patients positive for RF or ACPA (SPRA) are considered to manifest an aggressive disease course compared with seronegative RA patients (SNRA). However, the relationship between seropositivity and measures of disease severity other than radiologic outcome is disputed. In this study, we sought to compare the clinical presentations and treatment outcomes of SNRA and SPRA patients...
2018: PloS One
https://www.readbyqxmd.com/read/29622913/the-difficult-rheumatology-diagnosis
#11
Navin Kumar Devaraj
Background: Rheumatoid arthritis is a devastating condition. More so, the diagnosis of seronegative rheumatoid arthritis is often fraught off with much uncertainty and that leads to further suffering to the unfortunate patient. Case Details: This is a case of Madam A, who presented with many non-specific symptoms and signs involving many systems which was finally diagnosed as seronegative rheumatoid arthritis. This case explores the challenges in reaching this uncommon diagnosis and how anti-inflammatory drugs can bring a miraculous relief to the patient's suffering...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29610697/a-case-of-spondyloarthritis-in-patient-affected-by-unicentric-castleman-s-disease-effectively-managed-with-surgery-resection-and-tocilizumab-treatment
#12
M Filippini, S Cartella, O Bonzanini, E Morello, A Tincani
A 38-year-old woman was referred to our hospital for rheumatologic manifestations (migrant arthritis and tenosynovitis), without psoriasis or family history of psoriasis, gastroenteric manifestations, or recent genitourinary infections. The instrumental and laboratory tests have suggested a diagnosis of undifferentiated seronegative HLA-B27-positive spondyloarthritis with predominantly peripheral involvement. The symptoms were very severe and resistant to anti-inflammatory drugs and steroids. She had a history of hyaline-vascular unicentric Castleman's disease (HBV, HIV, and HHV-8 negative) treated with surgery resection...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29542372/interleukin-6-and-iga-rheumatoid-factor-are-crucial-for-baseline-erosiveness-and-anti-citrullinated-peptide-antibodies-for-radiographic-progression-in-early-rheumatoid-arthritis-treated-according-to-a-treat-to-target-strategy
#13
A L Fedele, L Petricca, B Tolusso, S Alivernini, S Canestri, C Di Mario, S L Bosello, G Ferraccioli, E Gremese
OBJECTIVES: To define baseline clinical and immunological characteristics [anti-citrullinated peptide antibodies (ACPAs), immunoglobulin M (IgM)- and IgA-rheumatoid factor (RF), and interleukin-6 (IL-6) levels] involved in determining baseline erosiveness, outcome, and radiographic progression among seropositive and seronegative early rheumatoid arthritis (ERA) patients. METHOD: The 408 ERA patients enrolled in the study were monitored every 3 months according to the treat-to-target strategy...
March 15, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29512823/variable-domain-n-linked-glycosylation-and-negative-surface-charge-are-key-features-of-monoclonal-acpa-implications-for-b-cell-selection
#14
Katy A Lloyd, Johanna Steen, Khaled Amara, Philip J Titcombe, Lena Israelsson, Susanna L Lundström, Diana Zhou, Roman A Zubarev, Evan Reed, Luca Piccoli, Cem Gabay, Antonio Lanzavecchia, Dominique Baeten, Karin Lundberg, Daniel L Mueller, Lars Klareskog, Vivianne Malmström, Caroline Grönwall
Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic. Herein, we demonstrate the frequency of variable-region glycosylation in single-cell cloned mAbs. A total of 14 ACPA mAbs were evaluated for predicted N-linked glycosylation motifs in silico, and compared to 452 highly-mutated mAbs from RA patients and controls. Variable region N-linked motifs (N-X-S/T) were strikingly prevalent within ACPA (100%) compared to somatically hypermutated (SHM) RA bone marrow plasma cells (21%), and synovial plasma cells from seropositive (39%) and seronegative RA (7%)...
March 7, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29486148/glycomics-meets-artificial-intelligence-potential-of-glycan-analysis-for-identification-of-seropositive-and-seronegative-rheumatoid-arthritis-patients-revealed
#15
Erika Chocholova, Tomas Bertok, Eduard Jane, Lenka Lorencova, Alena Holazova, Ludmila Belicka, Stefan Belicky, Danica Mislovicova, Alica Vikartovska, Richard Imrich, Peter Kasak, Jan Tkac
In this study, one hundred serum samples from healthy people and patients with rheumatoid arthritis (RA) were analyzed. Standard immunoassays for detection of 10 different RA markers and analysis of glycan markers on antibodies in 10 different assay formats with several lectins were applied for each serum sample. A dataset containing 2000 data points was data mined using artificial neural networks (ANN). We identified key RA markers, which can discriminate between healthy people and seropositive RA patients (serum containing autoantibodies) with accuracy of 83...
June 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29482663/impaired-lymph-node-stromal-cell-function-during-the-earliest-phases-of-rheumatoid-arthritis
#16
Janine S Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H Ramwadhdoebe, Johanna F Semmelink, Karen I Maijer, IJsbrand A Zijlstra, Mario Maas, Danielle M Gerlag, Teunis B H Geijtenbeek, Paul P Tak, Reina E Mebius, Lisa G M van Baarsen
BACKGROUND: Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses through their intimate connection with leucocytes. We postulate that malfunctioning of LNSCs creates a microenvironment in which normal immune responses are not properly controlled, possibly leading to autoimmune disease. In this study we established an experimental model for studying the functional capacities of human LNSCs during RA development...
February 26, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29480896/from-patients-with-arthralgia-pre-ra-and-recently-diagnosed-ra-what-is-the-current-status-of-understanding-ra-pathogenesis
#17
REVIEW
Marlieke Molendijk, Johanna Mw Hazes, Erik Lubberts
It is believed that therapy for rheumatoid arthritis (RA) is the most effective and beneficial within a short time frame around RA diagnosis. This insight has caused a shift from research in patients with established RA to patients at risk of developing RA and recently diagnosed patients. It is important for improvement of RA therapy to understand when and what changes occur in patients developing RA. This is true for both seropositive and seronegative patients. Activation of the immune system as presented by autoantibodies, increased cytokine and chemokine production, and alterations within several immune cells occur during RA development...
2018: RMD Open
https://www.readbyqxmd.com/read/29478412/nivolumab-induced-remitting-seronegative-symmetrical-synovitis-with-pitting-edema-in-a-patient-with-melanoma-a-case-report
#18
Linh Ngo, Eric Miller, Peter Valen, Elie Gertner
BACKGROUND: Novel immune checkpoint inhibitors have been often utilized for different types of malignancies as salvage therapy with varying success. One obstacle to immune checkpoint inhibitor use is the higher incidence of immune-mediated side effects that can prompt discontinuation of therapy. Remitting seronegative symmetrical synovitis with pitting edema has been described with immune checkpoint inhibitors only once previously. We report a case of a patient who developed remitting seronegative symmetrical synovitis with pitting edema related to immune checkpoint inhibitor therapy and stress that these symptoms can be managed without cessation of immune checkpoint inhibitor therapy...
February 26, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29449498/early-psoriatic-arthritis-versus-early-seronegative-rheumatoid-arthritis-role-of-dermoscopy-combined-with-ultrasonography-for-differential-diagnosis
#19
Alen Zabotti, Enzo Errichetti, Francesca Zuliani, Luca Quartuccio, Stefania Sacco, Giuseppe Stinco, Salvatore De Vita
OBJECTIVE: Exclusion of psoriatic skin/nail lesions is important in differentiating early seronegative rheumatoid arthritis (ERA) from early polyarticular psoriatic arthritis (EPsA) and such manifestations may go unnoticed in atypical or minimally expressed cases. The aim of this study is to assess the usefulness of integrated rheumatological-dermatological evaluation in highlighting dermatological lesions missed on rheumatological examination and to investigate the role of ultrasonography (US) and dermoscopy in improving the recognition of subclinical psoriatic findings...
May 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29409751/the-role-of-gut-microbiota-and-il-23-il-17-pathway-in-ankylosing-spondylitis-immunopathogenesis-new-insights-and-updates
#20
REVIEW
Farhad Babaie, Milad Hasankhani, Hamed Mohammadi, Elham Safarzadeh, Alireza Rezaiemanesh, Reza Salimi, Behzad Baradaran, Zohreh Babaloo
Ankylosing spondylitis (AS) is a type of arthritis that is referred to a group of chronic immune-mediated inflammatory diseases termed as seronegative spondyloarthropathies or spondyloarthritides. It typically affects the joints of the spinal and axial skeleton and exhibits common clinical features and genetic factors such as human leukocyte antigen class I allele HLA-B27, the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1), and environmental factors such as microbial triggers. Although the precise etiopathogenic mechanisms that implicate the pathogenesis of AS have still remained to be clarified, the IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of AS...
April 2018: Immunology Letters
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