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Seronegative arthritis

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https://www.readbyqxmd.com/read/28899798/is-acpa-positivity-the-main-driver-for-rheumatoid-arthritis-treatment-pros-and-cons
#1
REVIEW
Stefano Alivernini, Mauro Galeazzi, Hagit Peleg, Barbara Tolusso, Elisa Gremese, Gianfranco Ferraccioli, Yaakov Naparstek
Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared to seronegative RA. Moreover, ACPA status is associated with favorable response to biologics targeting pathways involving autoantibody producing cells as B lymphocytes...
September 9, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28879052/obesity-is-a-strong-predictor-of-worse-clinical-outcomes-and-treatment-responses-in-early-rheumatoid-arthritis-results-from-the-swefot-trial
#2
Adrian Levitsky, Kerstin Brismar, Ingiäld Hafström, Karen Hambardzumyan, Cecilia Lourdudoss, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVES: The aim of this paper was to analyse the impact of obesity, in addition to known predictors, on disease outcome in early rheumatoid arthritis (RA). METHODS: Body mass index (BMI) was available in 260 patients from the Swedish pharmacotherapy trial (SWEFOT). Differences in disease activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese BMI >30, n=43; overweight BMI=25-29...
2017: RMD Open
https://www.readbyqxmd.com/read/28864556/massive-splenomegaly-due-to-concurrent-primary-epstein-barr-virus-and-cytomegalovirus-infection-in-a-patient-on-adalimumab
#3
Barathy Rani Ramasamy, Patrick Charles, Douglas Johnson, Albert Frauman
A 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea. On examination, he had obvious splenomegaly but no lymphadenopathy or pharyngitis. Full blood count revealed mild neutropenia and significant lymphocytosis, with a blood film showing atypical lymphocytes. Liver function tests were mildly deranged with a mixed hepatitic and obstructive pattern. Ultrasound confirmed massive splenomegaly with a span of 21 cm in the long axis...
September 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28808511/large-endocardial-rheumatoid-nodules-a-case-report-and-review-of-the-literature
#4
Allen Vantrease, Christopher Trabue, James Atkinson, Paul McNabb
Rheumatoid nodules occur frequently in patients with rheumatoid arthritis and are the most common cutaneous manifestation of the disease. Although uncommon, rheumatoid nodules may also occur on cardiac valves, where they may be large and clinically significant. They may embolize and cause stroke. They may cause regurgitant murmurs, or they may result in valvular destruction. Echocardiographically, they may mimic an atrial myxoma or appear as a vegetation. We present a patient with seronegative rheumatoid arthritis who developed an acute embolic stroke; he had peripheral stigmata of infective endocarditis on physical examination and echocardiography revealed a mitral valve vegetation...
July 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/28792533/increased-amount-of-phosphorylated-proinflammatory-osteopontin-in-rheumatoid-arthritis-synovia-is-associated-to-decreased-tartrate-resistant-acid-phosphatase-5b-5a-ratio
#5
Jani Luukkonen, Laia Mira Pascual, Christina Patlaka, Pernilla Lång, Sanna Turunen, Jussi Halleen, Tomi Nousiainen, Maarit Valkealahti, Juha Tuukkanen, Göran Andersson, Petri Lehenkari
BACKGROUND: Osteopontin (OPN) is an immunoregulatory protein which production increases in both rheumatoid arthritis (RA) and osteoarthritis (OA). Phosphorylated osteopontin (Phospho-OPN) is known to increase macrophage and osteoclast activation, this process is controlled by extracellular tartrate-resistant acid phosphatase (TRAcP), also a biomarker for RA. Here, we evaluated the phosphorylation status of OPN in RA and OA synovia, as well as its correlation with TRAcP isoforms. METHODS: Synovial tissue and fluid were obtained from 24 RA (14 seropositive and 10 seronegative) and 24 OA patients...
2017: PloS One
https://www.readbyqxmd.com/read/28746056/volar-papulonodules-in-a-patient-with-seronegative-rheumatoid-arthritis
#6
Justin P Bandino, Dirk M Elston
No abstract text is available yet for this article.
July 18, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28743354/analysis-of-four-serum-biomarkers-in-rheumatoid-arthritis-association-with-extra-articular-manifestations-in-patients-and-arthralgia-in-relatives
#7
Flávia R Nass, Thelma L Skare, Isabela Goeldner, Renato Nisihara, Iara T Messias-Reason, Shirley R R Utiyama
OBJECTIVES: To evaluate the frequency of four serum biomarkers in RA patients and their relatives and identify possible associations with clinical findings of the disease. METHODS: This was a transversal analytical study. Anti-cyclic citrullinated peptide (anti-CCP), anti-mutated citrullinated vimentin (anti-MCV) and IgA-rheumatoid factor (RF) were determined by ELISA and IgM-RF by latex agglutination in 210 RA patients, 198 relatives and 92 healthy controls from Southern Brazil...
July 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28646772/prevalence-of-immune-related-systemic-adverse-events-in%C3%A2-patients-treated-with-anti-programmed-cell-death-1-anti-programmed-cell-death-ligand-1-agents-a-single-centre-pharmacovigilance-database-analysis
#8
Sébastien Le Burel, Stéphane Champiat, Christine Mateus, Aurélien Marabelle, Jean-Marie Michot, Caroline Robert, Rakiba Belkhir, Jean-Charles Soria, Salim Laghouati, Anne-Laure Voisin, Olivier Fain, Arsène Mékinian, Laetitia Coutte, Tali-Anne Szwebel, Laetitia Dunogeant, Bertrand Lioger, Cécile Luxembourger, Xavier Mariette, Olivier Lambotte
AIM: The growing use of immune checkpoint inhibitors (ICIs) is associated with the occurrence of immune-related adverse events (irAEs). Few data are published on systemic, immunohaematological and rheumatic irAEs. In a pharmacovigilance database analysis, we screened for these irAEs and calculated their prevalence. PATIENTS AND METHODS: Participants were recruited via Registre des Effets Indésirables Sévères des Anticorps Monoclonaux Immunomodulateurs en Cancérologie (REISAMIC)(1) a French registry of grade ≥2 irAEs occurring in ICI-treated patients...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28643530/assessment-of-local-carotid-stiffness-in-seronegative-and-seropositive-rheumatoid-arthritis
#9
Abdullah Nabi Aslan, Ayşe Nur Şirin Özcan, Şükran Erten, Yakup Alsancak, Tahir Durmaz
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic, inflammatory disease associated with increased risk of cardiovascular (CV) disease. Arterial stiffness (AS) is an independent predictor of CV events. This study aimed to analyse local carotid AS parameters in seronegative and seropositive RA patients. DESIGN: Of 347 consecutive RA patients, we selected specifically those who were free of established CV diseases and risk factors. As a result, 140 patients (126 women, 52...
October 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/28631700/-polymorphism-in-the-regulatory-regions-%C3%B0-2578a-and-c936t-of-the-vascular-endothelial-growth-factor-vegf-a-gene-in-russian-women-with-rheumatoid-arthritis
#10
A V Shevchenko, V F Prokofyev, M A Korolev, N E Banshchikova, V I Konenkov
AIM: To analyze polymorphism in the regulatory regions of the vascular endothelial growth factor (VEGF) gene in female patients with rheumatoid arthritis (RA). SUBJECTS AND METHODS: The investigation enrolled 257 female patients with RA. A control group consisted of 297 women without chronic diseases. The investigators examined the single-nucleotide polymorphism of VEGF-А2578С in the promoter region (rs699947) and that of VEGF+С936Т 3 in the retranslated region (rs3025039) of the gene...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28589668/strongly-positive-anti-ccp-antibodies-in-patients-with-sacroiliitis-or-reactive-arthritis-post-e-%C3%A2-coli-infection-a-mini-case-series-based-review
#11
Miljyot Singh Sangha, Matthew Liam Wright, Coziana Ciurtin
We report here on four cases of patients with strongly positive anti-citrullinated cyclic peptides (anti-CCP) antibodies and clinical features of seronegative spondyloarthritis (SpA) and reactive arthritis. The four patients had various clinical presentations: one had an initial diagnosis of seropositive rheumatoid arthritis (RA) with involvement of the sacroiliac joints (similar to previous reports of the association of two diseases); one had a clinical picture of reactive arthritis following an episode of an Escherichia coli positive urinary tract infection; and two had asymmetrical sacroiliitis (SII), but no evidence of peripheral joint involvement (never reported before)...
June 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28555437/autoimmunity-in-2016
#12
REVIEW
Carlo Selmi
The number of peer-reviewed articles published during the 2016 solar year and retrieved using the "autoimmunity" key word remained stable while gaining a minimal edge among the immunology articles. Nonetheless, the quality of the publications has been rising significantly and, importantly, acquisitions have become available through scientific journals dedicated to immunology or autoimmunity. Major discoveries have been made in the fields of systemic lupus erythematosus, rheumatoid arthritis, autoimmunity of the central nervous system, vasculitis, and seronegative spondyloarthrithritides...
August 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28551593/eosinophilic-granulomatosis-with-polyangiitis-and-mononeuritis-multiplex-responded-to-induction-cyclophosphamide
#13
Nurashikin Mohammad, Wan Syamimee Wan Ghazali
We report a case of 28-year-old Malay woman who initially presented with multiple joints pain with underlying poorly controlled asthma since her childhood. She was treated as seronegative arthritis. However, the involvement of joints, asthma and high-eosinophil counts raised suspicion of Churg-Strauss syndrome. This disease is undoubtedly rare in Malaysians or even in Asian populations. After appropriate therapy was delivered for the correct diagnosis her clinical condition improved. She is currently receiving maintenance treatment...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28545554/whipple-s-disease-mimicking-rheumatoid-arthritis-can-cause-misdiagnosis-and-treatment-failure
#14
Cornelia Glaser, Siegbert Rieg, Thorsten Wiech, Christine Scholz, Dominique Endres, Oliver Stich, Peter Hasselblatt, Walter Geißdörfer, Christian Bogdan, Annerose Serr, Georg Häcker, Reinhard E Voll, Jens Thiel, Nils Venhoff
BACKGROUND: Whipple's disease, a rare chronic infectious disorder caused by Tropheryma whipplei, may present with predominant joint manifestations mimicking rheumatoid arthritis (RA). METHODS: A retrospective single-center cohort study of seven patients was performed. Clinical symptoms were assessed by review of medical charts and Whipple's disease was diagnosed by periodic-acid-Schiff-stain and/or Tropheryma whipplei-specific polymerase-chain-reaction. RESULTS: Median age at disease onset was 54 years, six patients were male...
May 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28502061/validation-of-administrative-case-ascertainment-algorithms-for-chronic-childhood-arthritis-in-manitoba-canada
#15
Natalie Jane Shiff, Kiem Oen, Rasheda Rabbani, Lisa M Lix
We validated case ascertainment algorithms for juvenile idiopathic arthritis (JIA) in the provincial health administrative databases of Manitoba, Canada. A population-based pediatric rheumatology clinical database from April 1st 1980 to March 31st 2012 was used to test case definitions in individuals diagnosed at ≤15 years of age. The case definitions varied the number of diagnosis codes (1, 2, or 3), time frame (1, 2 or 3 years), time between diagnoses (ever, >1 day, or ≥8 weeks), and physician specialty...
May 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28485187/tumour-necrosis-factor-%C3%AE-etanercept-complexes-in-serum-predict-long-term-efficacy-of-etanercept-treatment-in-seronegative-rheumatoid-arthritis
#16
E Berthold, B Månsson, B Gullstrand, P Geborek, T Saxne, A A Bengtsson, R Kahn
OBJECTIVE: To study whether serum levels of tumour necrosis factor-α (TNF-α), free or bound to etanercept, in biological-naïve adults with rheumatoid arthritis (RA) could predict the long-term efficacy of etanercept, measured as drug survival. METHOD: We identified 145 biological-naïve patients with RA starting treatment with etanercept at the Department of Rheumatology, Skåne University Hospital (1999-2008), of whom 16 had seronegative and 129 seropositive RA...
May 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28473097/acr-appropriateness-criteria-%C3%A2-chronic-extremity-joint-pain-suspected-inflammatory-arthritis
#17
Jon A Jacobson, Catherine C Roberts, Jenny T Bencardino, Marc Appel, Erin Arnold, Steven J Baccei, R Carter Cassidy, Eric Y Chang, Michael G Fox, Bennett S Greenspan, Soterios Gyftopoulos, Mary G Hochman, Douglas N Mintz, Joel S Newman, Zehava S Rosenberg, Nehal A Shah, Kirstin M Small, Barbara N Weissman
Evaluation for suspected inflammatory arthritis as a cause for chronic extremity joint pain often relies on imaging. This review first discusses the characteristic osseous and soft tissue abnormalities seen with inflammatory arthritis and how they may be imaged. It is essential that imaging results are interpreted in the context of clinical and serologic results to add specificity as there is significant overlap of imaging findings among the various types of arthritis. This review provides recommendations for imaging evaluation of specific types of inflammatory arthritis, including rheumatoid arthritis, seronegative spondyloarthropathy, gout, calcium pyrophosphate dihydrate disease (or pseudogout), and erosive osteoarthritis...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28451788/the-role-of-autoantibodies-in-the-pathophysiology-of-rheumatoid-arthritis
#18
REVIEW
V F A M Derksen, T W J Huizinga, D van der Woude
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. The presence of autoantibodies in the sera of RA patients has provided many clues to the underlying disease pathophysiology. Based on the presence of several autoantibodies like rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), anti-carbamylated protein antibodies (anti-CarP), and more recently anti-acetylated protein antibodies RA can be subdivided into seropositive and seronegative disease. The formation of these autoantibodies is associated with both genetic and environmental risk factors for RA, like specific human leukocyte antigen (HLA) alleles and smoking...
June 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#19
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28399834/compliance-and-persistence-with-oral-bisphosphonates-for-the-treatment-of-osteoporosis-in-female-patients-with-rheumatoid-arthritis
#20
Ji-Heh Park, Eun-Kyoung Park, Dong-Wan Koo, Shinwon Lee, Sun-Hee Lee, Geun-Tae Kim, Seung-Geun Lee
BACKGROUND: Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding adherence with oral BPs have focused on postmenopausal osteoporosis, but little attention has been given to patients with rheumatoid arthritis (RA). Thus, we investigated compliance and persistence with oral BPs in the treatment of osteoporosis and analyzed risk factors for poor adherence in female patients with (RA) in real setting...
April 11, 2017: BMC Musculoskeletal Disorders
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