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Topiosomerase

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https://www.readbyqxmd.com/read/2171756/phorbol-ester-effects-on-topoisomerase-ii-activity-and-gene-expression-in-hl-60-human-leukemia-cells-with-different-proclivities-toward-monocytoid-differentiation
#1
L A Zwelling, M Hinds, D Chan, E Altschuler, J Mayes, T F Zipf
We examined the effects of phorbol ester treatment on topoisomerase II-mediated events in two human leukemia cell lines with different proclivities toward phorbol ester-induced monocytoid differentiation. HL-60 is the parent line that will terminally differentiate; 1E3 is a derived line that will not terminally differentiate. Within 24 h of phorbol ester treatment, etoposide-induced, topoisomerase II-mediated DNA cleavage declined 10-fold, whereas 4'-(9-acridinylamino)-methanesulfon-m-anisidide- induced DNA cleavage declined 3-fold in HL-60...
November 15, 1990: Cancer Research
https://www.readbyqxmd.com/read/1321413/kinetoplast-associated-dna-topoisomerase-in-crithidia-fasciculata-crosslinking-of-mitochondrial-topoisomerase-ii-to-both-minicircles-and-maxicircles-in-cells-treated-with-the-topoisomerase-inhibitor-vp16
#2
D S Ray, J C Hines, M Anderson
The mitochondrial DNA of the trypanosomatid Crithidia fasciculata consists of thousands of copies of a 2.5 kb minicircle and a small number of 37kb maxicircles catenated into a single enormous network. Treatment of C. fasciculata with the type II DNA topoisomerase inhibitor VP16 produces cleavable complexes of a type II DNA topiosomerase with both minicircles and maxicircles. A combined Southern and Western blot analysis of the cleaved DNA species released from the network by SDS treatment has identified topollmt, the kinetoplast-associated topisomerase, in covalent complexes with linear forms of minicircle and maxicircle DNAs...
July 11, 1992: Nucleic Acids Research
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