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https://www.readbyqxmd.com/read/29775644/redox-signal-mediated-trpm2-promotes-ang-ii-induced-adipocyte-insulin-resistance-via-ca-2-dependent-camkii-jnk-cascade
#1
Min Gao, Yu Du, Jing-Wen Xie, Jing Xue, Yi-Ting Wang, Li Qin, Ming-Ming Ma, Yong-Bo Tang, Xiao-Yan Li
BACKGROUND AND OBJECTIVE: Redox-sensitive transient receptor potential melastatin 2 (TRPM2) is a Ca2+ -permeable, nonselective cation channel which plays a crucial role in various physiological processes. However, little is known whether TRPM2 is involved in adipocyte dysfunction during hypertension. In the present study, we determined the role of TRPM2 in angiotensin II (Ang II)-induced insulin resistance in adipocytes and the underlying mechanisms. METHODS: Ang II-induced adipocyte insulin resistant model was conducted...
May 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29774534/adverse-selection-into-and-within-the-individual-health-insurance-market-in-california-in-2014
#2
Vicki Fung, Cassandra G K Peitzman, Julie Shi, Catherine Y Liang, William H Dow, Alan M Zaslavsky, Bruce H Fireman, Stephen F Derose, Michael E Chernew, Joseph P Newhouse, John Hsu
OBJECTIVE: The Affordable Care Act (ACA) introduced reforms to mitigate adverse selection into and within the individual insurance market. We examined the traits and predicted medical spending of enrollees in California post-ACA. DATA SOURCES: Survey of 2,103 enrollees in individual market plans, on- and off-exchange, in 2014. STUDY DESIGN: We compared actual versus potential participants using data from the 2014 California Health Interview Survey on respondents who were individually insured or uninsured...
May 17, 2018: Health Services Research
https://www.readbyqxmd.com/read/29772456/new-insights-into-the-in-vitro-biological-effects-in-silico-docking-and-chemical-profile-of-clary-sage-salvia-sclarea-l
#3
Gokhan Zengin, Ismail Senkardes, Adriano Mollica, Carene Marie Nancy Picot-Allain, Gizem Bulut, Ahmet Dogan, M Fawzi Mahomoodally
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78 mg GAE/g extract and 40...
May 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29771741/impacts-of-the-affordable-care-act-on-community-health-centers-characteristics-of-new-patients-and-early-changes-in-delivery-of-care
#4
Brigit Hatch, Ning Smith, Mary Ann McBurnie, Thu Quach, Kenneth H Mayer, Mary J Dunne, Erika Cottrell
The aim of this study was to assess the impact of the Affordable Care Act (ACA) on community health centers (CHCs). Using electronic health records from the Community Health Applied Research Network, we assessed new patient characteristics, office visit volume, and payer distribution among CHC patients before and after ACA implementation, 2011-2014 (n = 442 455). New patients post-ACA were younger, more likely to be female and have chronic health conditions, and utilized more primary care (P < .05 for each)...
May 15, 2018: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/29771619/affordable-care-act-impact-in-kentucky-increasing-access-reducing-disparities
#5
Lynn A Blewett, Colin Planalp, Giovann Alarcon
OBJECTIVES: To examine health insurance disparities since Kentucky's implementation of the Affordable Care Act (ACA). METHODS: Using the American Community Survey, we estimated coverage rates by race/ethnicity before and after implementation of the ACA (2013 and 2015), and we estimated whether groups were over- or underrepresented among the uninsured, compared with their share of the state population. RESULTS: Kentucky's uninsurance rate declined from 14...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29770267/role-of-noninvasive-imaging-of-cerebral-arterial-system-in-ischemic-stroke-comparison-of-transcranial-color-coded-doppler-sonography-with-magnetic-resonance-angiography
#6
Betty Simon, Sunithi Elizabeth Mani, Shyamkumar Nidugala Keshava, Mathew Alexander, Sanjith Aaron
Aim: To determine the accuracy of transcranial color-coded Doppler sonography (TCCS) in the evaluation of cerebral arterial system in patients with ischemic stroke attending a tertiary care hospital in South India. Objectives: (1) To describe the topographical distribution of atherosclerotic lesions in the cerebral circulation in patients presenting with ischemic stroke from the Indian subcontinent and (2) to determine the accuracy of TCCS for detection and quantification of intracranial stenoses in various segments of the intracerebral arterial system in comparison with magnetic resonance angiography (MRA)...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29762820/relation-between-mycoplasma-infection-and-recurrent-spontaneous-abortion
#7
C-J Cao, Y-F Wang, D-M Fang, Y Hu
OBJECTIVE: This study explores the possible relation between cervical infections with Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) and the occurrence of recurrent spontaneous abortion (RSA). PATIENTS AND METHODS: 132 patients with RSA (observation group) and 96 normal pregnancy volunteers undergoing planned abortions (control group) were selected successively and enrolled in the investigation. Cervical secretion samples were obtained for each subject...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29762274/decomposing-medicaid-spending-during-health-system-reform-and-aca-expansion-evidence-from-oregon
#8
Stephanie Renfro, Stephan Lindner, K John McConnell
BACKGROUND: Expansion of the Medicaid program is likely to create new budgetary pressures at the state and federal levels, creating a need for greater understanding of how program dollars are allocated and what drives spending growth. OBJECTIVE: To characterize Oregon Medicaid expenditures across diseases and medical conditions, during periods of payment reform and coverage expansion. RESEARCH DESIGN: Decomposition of changes in Medicaid expenditures using a person-based allocation of spending across 50 diseases/medical conditions...
May 12, 2018: Medical Care
https://www.readbyqxmd.com/read/29757880/leveraging-health-care-reform-to-accelerate-nurse-practitioner-full-practice-authority
#9
Heather M Brom, Pamela J Salsberry, Margaret Clark Graham
BACKGROUND AND PURPOSE: Since development of the nurse practitioner (NP) role, NPs have been advocating for policy allowing them to practice to the full extent of their training. The aim of this research was to determine whether passage of the Affordable Care Act (ACA) had an impact on expansion of NPs' scope of practice. METHODS: This was a retrospective descriptive study of NPs' scope of practice legislation from 1994 to 2016 using regulatory theory. Data sources included annual reports on NP legislation and state-level legislative and media coverage...
March 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29757690/market-stabilization-stalls-states-step-in
#10
Timothy Stoltzfus Jost
As federal efforts to stabilize the individual market foundered on abortion coverage, states adopted a variety of approaches. The 2019 payment notice broadened states' options in implementing the ACA.
May 14, 2018: Health Affairs
https://www.readbyqxmd.com/read/29754279/changes-in-health-insurance-coverage-and-barriers-to-health-care-access-among-individuals-with-serious-psychological-distress-following-the-affordable-care-act
#11
Priscilla Novak, Andrew C Anderson, Jie Chen
The Affordable Care Act (ACA) aims to expand health insurance coverage and minimize financial barriers to receiving health care services for individuals. However, little is known about how the ACA has impacted individuals with mental health conditions. This study finds that the implementation of the ACA is associated with an increase in rate of health insurance coverage among nonelderly adults with serious psychological distress (SPD) and a reduction in delaying and forgoing necessary care. The ACA also reduced the odds of an individual with SPD not being able to afford mental health care...
May 12, 2018: Administration and Policy in Mental Health
https://www.readbyqxmd.com/read/29750378/dmso-as-switchable-alkylating-agent-in-heteroarene-c-h-functionalization
#12
Aleyda Garza-Sanchez, Tuhin Patra, Adrian Tlahuext-Aca, Felix Strieth-Kalthoff, Frank Glorius
Herein, we report a novel strategy for the activation of DMSO to act as a versatile alkylating agent in heteroarene C-H functionalization. This direct, simple, and mild switch between methylation/trideuteromethylation and methylthiomethylation of heteroarenes was achieved under reagent controlled photoredox catalysis conditions. The proposed mechanism is supported by both experimental and theoretical studies.
May 11, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29750018/inactivation-of-nuclear-factor-%C3%AE%C2%BAb-by-mip-based-drug-combinations-augments-cell-death-of-breast-cancer-cells
#13
Menaga Subramaniam, Su Ki Liew, Lionel LA In, Khalijah Awang, Niyaz Ahmed, Noor Hasima Nagoor
Background: Drug combination therapy to treat cancer is a strategic approach to increase successful treatment rate. Optimizing combination regimens is vital to increase therapeutic efficacy with minimal side effects. Materials and methods: In the present study, we evaluated the in vitro cytotoxicity of double and triple combinations consisting of 1'S-1'-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP) and cisplatin (CDDP) against 14 various human cancer cell lines to address the need for more effective therapy...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29745327/progress-in-one-pot-bioconversion-of-cephalosporin-c-to-7-aminocephalosporanic-acid
#14
Qiang Tan, Jie Qiu, Xiang Luo, Yewang Zhang, Yuting Liu, Yuquan Chen, Jing Yuan, Wei Liao
BACKGROUND: Cephalosporins are the most widely used semisynthetic antibiotics, which acted on bacterial cell wall (peptidoglycan) synthesis. The key intermediate for fabricating about two-thirds of cephalosporins in clinical use is 7-aminocephalosporanic acid (7-ACA), which derived from chemical or enzymatic deacylation of the natural antibiotic cephalosporin C (CPC). The chemical deacylation process has been replaced by the enzymatic deacylation process because the chemical process required harsh conditions and released toxic waste...
May 8, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29745303/the-effect-of-aca-state-medicaid-expansions-on-medical-out-of-pocket-expenditures
#15
Joelle Abramowitz
This article considers the extent to which Affordable Care Act state Medicaid expansions alleviated the burden of out-of-pocket costs associated with obtaining health insurance and medical care using data from the 2011 to 2016 Current Population Survey Annual Social and Economic Supplement. Using a difference-in-differences framework, the analysis examines effects of the Medicaid expansions on out-of-pocket expenditures for health insurance premiums and medical care, comparing expenditures across expansion and nonexpansion states before and after the expansions were implemented, performing separate analyses for individuals with family income at various eligibility cutoff levels in the first and second years of expansion implementation...
May 1, 2018: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29744622/lethal-and-sublethal-responses-in-the-fish-odontesthes-bonariensis-exposed-to-chlorpyrifos-alone-or-under-mixtures-with-endosulf%C3%A3-n-and-lambda-cyhalothrin
#16
Viviana López Aca, Patricia Verónica Gonzalez, Pedro Carriquiriborde
Need for ecotoxicological information on local species has been recently highlighted as a priority issue in Latin America. In addition, little information has been found on concentration distances between lethal and sublethal effects, and the effect of mixtures at these two levels of analysis. Chlorpyrifos (CPF) is an organophosphate insecticide broadly used in soybean crops which has dramatically expanded in Latin America and other regions of the world. The aim of the present study was to evaluate lethal and sublethal effects of CPF, singly or in mixtures, on the inland "Pejerrey" (Odontesthes bonariensis) under laboratory conditions...
May 9, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29742668/effects-of-the-affordable-care-act-on-young-women-with-gynecologic-cancers
#17
Anna Jo Bodurtha Smith, Amanda N Fader
OBJECTIVE: To evaluate the effects of the dependent coverage mandate of the 2010 Affordable Care Act (ACA) on insurance status, stage at diagnosis, and receipt of fertility-sparing treatment among young women with gynecologic cancer. METHODS: We used a difference-in-differences design to assess insurance status, stage at diagnosis (stage I-II vs III-IV), and receipt of fertility-spearing treatment before and after the 2010 ACA among young women aged 21-26 years vs women aged 27-35 years...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29739828/anterior-cerebral-artery-embolism-during-thrombectomy-increases-disability-and-mortality
#18
Vanessa Chalumeau, Raphaël Blanc, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Jean-Philippe Desilles, Daniele Botta, Simon Escalard, William Boisseau, Benjamin Maïer, Julien Labreuche, Mickaël Obadia, Michel Piotin, Mikael Mazighi
OBJECTIVE: During thrombectomy, thromboembolic migration in previously unaffected territory may occur and is not systematically notified. We report our data on the incidence, predictors, and clinical outcome of anterior cerebral artery emboli (ACAE). METHODS: From a prospectively collected thrombectomy database of consecutive patients with anterior circulation stroke between January 2012 and December 2016, 690 angiographic images were analyzed to assess ACAE. The primary outcome was a favorable outcome, defined as a 3 month modified Rankin Scale score of 0-2 or equal to the pre-stroke score...
May 8, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29734277/shifts-in-medicaid-and-uninsured-payer-mix-at-safety-net-and-non-safety-net-hospitals-during-the-great-recession
#19
Kathryn R Fingar, Rosanna M Coffey, Andrew W Mulcahy, Roxanne M Andrews, Carol Stocks
There has been ongoing concern regarding the viability of safety-net hospitals (SNHs), which care for vulnerable populations. The authors examined payer mix at SNHs and non-SNHs during a period covering the Great Recession using data from the 2006 to 2012 Healthcare Cost and Utilization Project State Inpatient Databases from 38 states. The number of privately insured stays decreased at both SNHs and non-SNHs. Non-SNHs increasingly served Medicaid-enrolled and uninsured patients; in SNHs, the number of Medicaid stays decreased and uninsured stays remained stable...
May 2018: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/29730271/intraventricular-extension-of-an-aneurysmal-subarachnoid-hemorrhage-is-an-independent-predictor-of-a-worse-functional-outcome
#20
Mario Zanaty, Daichi Nakagawa, Robert M Starke, Enrique C Leira, Edgar A Samaniego, Waldo R Guerrero, James Torner, Yasunori Nagahama, Olatilewa Awe, Jeremy Greenlee, Joseph S Hudson, Lauren Allan, Reem Elwy, Nohra Chalouhi, Pascal Jabbour, Royce Woodroffe, Anthony Piscopo, David Hasan
OBJECTIVE: The objective of this study is to determine the impact of intraventricular hemorrhage (IVH) on the cognitive prognosis of subarachnoid hemorrhage (SAH) due to ruptured cerebral aneurysm, independent of the presence of intraparenchymal hemorrhage, hydrocephalus or vasospasm. PATIENT AND METHODS: A Retrospective review of a prospectively collected database of patients with aneurysmal SAH from July 2009 to November 2016 was performed. Patients were included if they had a saccular aneurysm with a Hunt-Hess grade (HHG) 1-3...
April 30, 2018: Clinical Neurology and Neurosurgery
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