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https://www.readbyqxmd.com/read/28521421/an-unusual-translocation-t-1-11-q21-q23-in-a-case-of-chronic-myeloid-leukemia-with-a-cryptic-philadelphia-chromosome
#1
Leandro Germán Gutiérrez, María Fernanda Noriega, Alejandro Laudicina, Mariana Quatrin, Raquel María Bengió, Irene Larripa
Chronic myeloid leukemia (CML) is characterized by the translocation t(9;22)(q34;q11) [Philadelphia (Ph) chromosome). Although not frequently occurring, additional chromosome abnormalities (ACAs) can be detected at diagnosis and a number have been associated with an adverse cytogenetic and molecular outcome. The present study reports a case of CML presenting with the translocation t(1;11)(q21;q23) and a cryptic Ph chromosome. The presence of ACAs could generate greater genetic instability, promoting the emergence of further alterations...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520483/effect-of-the-affordable-care-act-on-disparities-in-breastfeeding-the-case-of-maine
#2
Summer Sherburne Hawkins, Alice Noble, Christopher F Baum
OBJECTIVES: To evaluate the Affordable Care Act (ACA) breastfeeding provision and test whether changes in coverage affected women differently according to health insurance status. METHODS: We used the All-Payer Claims Database from Maine (2012-2014) to compare health insurance claims for lactation classes and breast pumps between women with private insurance and women with Medicaid (1) before the ACA breastfeeding provision, (2) after the provision came into effect, and (3) after health insurance expansion through the Marketplace...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28517042/the-impact-of-the-aca-medicaid-expansions-on-health-insurance-coverage-through-2015-and-coverage-disparities-by-age-race-ethnicity-and-gender
#3
George L Wehby, Wei Lyu
OBJECTIVE: Examine the ACA Medicaid expansion effects on Medicaid take-up and private coverage through 2015 and coverage disparities by age, race/ethnicity, and gender. DATA SOURCES: 2011-2015 American Community Survey for 3,137,989 low-educated adults aged 19-64 years. STUDY DESIGN: Difference-in-differences regressions accounting for national coverage trends and state fixed effects. PRINCIPAL FINDINGS: Expansion effects doubled in 2015 among low-educated adults, with a nearly 8 percentage-point increase in Medicaid take-up and 6 percentage-point decline in uninsured rate...
May 18, 2017: Health Services Research
https://www.readbyqxmd.com/read/28515140/three-year-impacts-of-the-affordable-care-act-improved-medical-care-and-health-among-low-income-adults
#4
Benjamin D Sommers, Bethany Maylone, Robert J Blendon, E John Orav, Arnold M Epstein
Major policy uncertainty continues to surround the Affordable Care Act (ACA) at both the state and federal levels. We assessed changes in health care use and self-reported health after three years of the ACA's coverage expansion, using survey data collected from low-income adults through the end of 2016 in three states: Kentucky, which expanded Medicaid; Arkansas, which expanded private insurance to low-income adults using the federal Marketplace; and Texas, which did not expand coverage. We used a difference-in-differences model with a control group and an instrumental variables model to provide individual-level estimates of the effects of gaining insurance...
May 17, 2017: Health Affairs
https://www.readbyqxmd.com/read/28513489/the-influence-of-corneal-collagen-cross-linking-on-anterior-chamber-in-keratoconus
#5
Nihat Polat, Abuzer Gunduz, Cemil Colak
AIMS: This study aimed to evaluate the effect of the corneal changes following corneal cross-linking (CXL) on the anterior chamber in keratoconus patients. MATERIALS AND METHODS: Forty-five eyes of 32 patients who had been diagnosed with progressive keratoconus and had undergone CXL were included in this retrospective study. The thinnest corneal thickness of the progressive keratoconus patients included in the study was >400 μ. The preoperative (T0), postoperative 6th month (T1), and postoperative 1st year (T2) anterior chamber volume (ACV), anterior chamber angle (ACA), and anterior chamber depth (ACD) scheimpflug imaging values were obtained for each eye...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28513249/medicaid-expansion-produces-long-term-impact-on-insurance-coverage-rates-in-community-health-centers
#6
Nathalie Huguet, Megan J Hoopes, Heather Angier, Miguel Marino, Heather Holderness, Jennifer E DeVoe
BACKGROUND: It is crucial to understand the impact of the Affordable Care Act (ACA). This study assesses changes in insurance status of patients visiting community health centers (CHCs) comparing states that expanded Medicaid to those that did not. METHODS: Electronic health record data on 875,571 patients aged 19 to 64 years with ≥ 1 visit between 2012 and 2015 in 412 primary care CHCs in 9 expansion and 4 nonexpansion states. We assessed changes in rates of total, uninsured, Medicaid-insured, and privately insured primary care and preventive care visits; immunizations administered, and medications ordered...
May 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28510521/a-seer-of-trump-s-coming-parses-repeal-and-replace
#7
Richard Mark Kirkner
Diana Furchtgott-Roth, a senior fellow at the Manhattan Institute, a freemarket think tank, confidently predicted back in October what few people saw coming-Donald Trump's electoral victory. Now she gives her take on the dismantling of the ACA and what might come after.
March 2017: Managed Care
https://www.readbyqxmd.com/read/28510514/door-is-open-for-hras-to-make-a-comeback
#8
Jan Greene
For four years, businesses that wanted to reimburse employees for their health insurance premiums rather than buying their coverage for them were told that that was no longer allowed under the ACA. But the health reimbursement arrangement (HRA) is back, brought back to life by provisions tucked into last year's 21st Century Cure Act.
March 2017: Managed Care
https://www.readbyqxmd.com/read/28508011/mandated-health-insurance-and-provider-reimbursement-via-private-insurance-evidence-from-the-massachusetts-health-reform
#9
Andrew Friedson, Allison Marier
In 2006, Massachusetts passed a reform that required individuals to purchase health insurance and provided subsidized health insurance to low-income individuals. The US Patient Protection and Affordable Care Act (ACA) was modeled after this reform, making Massachusetts an ideal place to look at potential outcomes from the ACA. Postreform, the proportion of the health-insured population in Massachusetts greatly increased, which potentially changed physician reimbursement for procedures as usage of care, particularly preventative care for children increased...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28504010/effects-of-selective-serotonin-reuptake-inhibitors-on-intraocular-pressure-and-anterior-segment-parameters-in-open-angle-eyes
#10
Gamze Uçan Gündüz, Neslihan Parmak Yener, Oğuzhan Kılınçel, Cem Gündüz
PURPOSE: To evaluate the short and long term effects of selective serotonin reuptake inhibitors (SSRIs) on intraocular pressure (IOP) and anterior segment parameters in open angle eyes. MATERIALS AND METHODS: This cross-sectional study included 325 eyes of 166 subjects. Subjects were divided into three groups; group 1 included 116 eyes of 58 patients receiving SSRIs for 1 week - 6 months, group 2 included 102 eyes of 53 patients receiving SSRIs for longer than 6 months, and group 3 included 107 eyes of 55 healthy subjects not receiving any drugs...
May 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28500925/revisiting-racial-disparities-in-access-to-surgical-management-of-drug-resistant-temporal-lobe-epilepsy-post-implementation-of-affordable-care-act
#11
Kanika Sharma, Piyush Kalakoti, Miriam Henry, Vikas Mishra, Rosario Maria Riel-Romero, Christina Notarianni, Anil Nanda, Hai Sun
OBJECTIVES: Prior to enactment of the Affordable Care Act(ACA), several reports demonstrated remarkable racial disparities in access to surgical care for epileptic patients. Implementation of ACA provided healthcare access to 7-16 million uninsured Americans. The current study investigates racial disparity post ACA era in (1) access to surgical management of drug-resistant temporal lobe epilepsy (DRTLE); (2) short-term outcomes in the surgical cohort. PATIENT AND METHODS: Adult patients with DRTLE registered in the National Inpatient Sample (2012-2013) were identified...
May 2, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28499992/segmentation-and-quantification-for-angle-closure-glaucoma-assessment-in-anterior-segment-oct
#12
Huazhu Fu, Yanwu Xu, Stephen Lin, Xiaoqin Zhang, Damon Wing Kee Wong, Jiang Liu, Alejandro Frangi, Mani Baskaran, Tin Aung
Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through Anterior Segment Optical Coherence Tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating image analysis. To address this problem, we propose a datadriven approach for automatic AS-OCT structure segmentation, measurement and screening...
May 10, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28498881/can-p40-polyclonal-replace-p63-clone-4a4-in-the-cytologic-diagnosis-of-pulmonary-non-small-cell-carcinoma
#13
Melissa Alexander, Jeanine Chiaffarano, Fang Zhou, Joan Cangiarella, Melissa Yee-Chang, Aylin Simsir
Objectives: Differentiating squamous cell carcinoma from adenocarcinoma (ACA) in cytology specimens can be challenging. Recent literature showed p40 had higher specificity than p63 for this purpose. Methods: We identified 190 cytology cases with p40 (polyclonal) and p63 (monoclonal clone 4A4) immunohistochemistry, including specimens from fine-needle aspirations (FNAs) and effusions. Results: ACAs of lung origin stained for p40 and p63 in 21% and 20% of cases, respectively, regardless of specimen site...
May 12, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28497898/additional-cytogenetic-abnormalities-and-variant-t-9-22-at-the-diagnosis-of-childhood-chronic-myeloid-leukemia-the-experience-of-the-international-registry-for-chronic-myeloid-leukemia-in-children-and-adolescents
#14
Frédéric Millot, Christelle Dupraz, Joelle Guilhot, Meinolf Suttorp, Françoise Brizard, Thierry Leblanc, Adalet Meral Güneş, Petr Sedlacek, Evelyne De Bont, Chi Kong Li, Krzysztof Kalwak, Birgitte Lausen, Srdjana Culic, Michael Dworzak, Emilia Kaiserova, Barbara De Moerloose, Farah Roula, Andrea Biondi, André Baruchel, François Guilhot
BACKGROUND: In the adult population with newly diagnosed chronic myeloid leukemia (CML), variant translocations are usually not considered to be impairing the prognosis, whereas some additional cytogenetic abnormalities (ACAs) are associated with a negative impact on survival. Because of the rarity of CML in the pediatric population, such abnormalities have not been investigated in a large group of children with CML. METHODS: The prognostic relevance of variant t(9;22) and ACAs at diagnosis was assessed in 301 children with CML in the chronic phase who were enrolled in the International Registry for Chronic Myeloid Leukemia in Children and Adolescents...
May 12, 2017: Cancer
https://www.readbyqxmd.com/read/28497289/systematic-analysis-of-the-lysine-acetylome-reveals-diverse-functions-of-lysine-acetylation-in-the-oleaginous-yeast-yarrowia-lipolytica
#15
Guangyuan Wang, Lizhong Guo, Wenxing Liang, Zhenming Chi, Lin Liu
Lysine acetylation of proteins, a major post-translational modification, plays a critical regulatory role in almost every aspects in both eukaryotes and prokaryotes. Yarrowia lipolytica, an oleaginous yeast, is considered as a model for bio-oil production due to its ability to accumulate a large amount of lipids. However, the function of lysine acetylation in this organism is elusive. Here, we performed a global acetylproteome analysis of Y. lipolytica ACA-DC 50109. In total, 3163 lysine acetylation sites were identified in 1428 proteins, which account for 22...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28490142/relation-between-polyphenol-profile-and-antioxidant-capacity-of-different-argentinean-wheat-varieties-a-boosted-regression-trees-study
#16
Natalia S Podio, María V Baroni, Daniel A Wunderlin
We report the polyphenol profile and antioxidant capacity (AC) of 12 Argentinean wheat varieties from different regions. The polyphenol profile was studied by HPLC-MS. The AC was measured by TEAC and FRAP. Twenty-five polyphenols were identified. ACA 315 and KLEIN GUERRERO varieties showed the highest content of polyphenols, whereas BIOINTA 3004, KLEIN CAPRICORNIO and LE 2330 showed the lowest one. ACA 315 presented the highest AC, while BIOINTA 3004 and KLEIN CAPRICORNIO showed the lowest one. Boosted Regression Trees (BRT) analyses helped finding significant correlations between AC and polyphenol profile, being hydroxybenzoic acid diglucoside, tryptophan, chrysoeriol-6,8-di-C-pentoside and isomers 4, 5, 9 and 12 of diferulic acids key compounds to explain the observed AC...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28489933/a-practical-model-for-the-train-set-utilization-the-case-of-beijing-tianjin-passenger-dedicated-line-in-china
#17
Yu Zhou, Leishan Zhou, Yun Wang, Xiaomeng Li, Zhuo Yang
As a sustainable transportation mode, high-speed railway (HSR) has become an efficient way to meet the huge travel demand. However, due to the high acquisition and maintenance cost, it is impossible to build enough infrastructure and purchase enough train-sets. Great efforts are required to improve the transport capability of HSR. The utilization efficiency of train-sets (carrying tools of HSR) is one of the most important factors of the transport capacity of HSR. In order to enhance the utilization efficiency of the train-sets, this paper proposed a train-set circulation optimization model to minimize the total connection time...
2017: PloS One
https://www.readbyqxmd.com/read/28488044/bilateral-carotid-anterior-cerebral-artery-anastomoses-associated-with-bilateral-ophthalmic-arteries-arising-from-the-middle-meningeal-arteries-diagnosed-by-magnetic-resonance-angiography-a-case-report
#18
Akira Uchino, Naoko Saito, Fumitaka Yamane
Anastomosis between the ophthalmic segment of the internal carotid artery and the A1-A2 junction of the anterior cerebral artery (ACA), described as carotid-ACA anastomosis or infraoptic course of the ACA, is rare and known to demonstrate right-sided predominance. We report a case of bilateral carotid-ACA anastomoses associated with bilateral ophthalmic arteries arising from the sphenoidal branch of the middle meningeal artery that were diagnosed by magnetic resonance (MR) angiography. Identification of rare arterial variations on MR angiography requires careful scrutiny of source images...
May 9, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28488036/perceptions-of-health-care-and-access-to-preventive-services-among-young-adults
#19
Raffy R Luquis, Weston S Kensinger
The enactment of the Affordable Care Act increased the emphasis on health promotion and disease prevention by making preventive care accessible for many Americans, especially young adults, who could remain on their parents or legal guardians' health insurance until the age of 26. Yet, many Americans receive only half of the recommended preventive care services, which highlight the need for the improvement of health promotion and prevention services. The aim of this study was to assess the relationship among access to health care insurance, perceptions about health insurance, and use of preventive care services among young adults...
May 9, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28485554/identification-of-aca-28-a-1-acetoxychavicol-acetate-analogue-compound-as-a-novel-modulator-of-erk-mapk-signaling-which-preferentially-kills-human-melanoma-cells
#20
Ryosuke Satoh, Kanako Hagihara, Kazuki Matsuura, Yoshiaki Manse, Ayako Kita, Tatsuki Kunoh, Takashi Masuko, Mariko Moriyama, Hiroyuki Moriyama, Genzoh Tanabe, Osamu Muraoka, Reiko Sugiura
The extracellular signal-regulated kinase (ERK) signaling pathway is essential for cell proliferation and is frequently deregulated in human tumors such as melanoma. Melanoma remains incurable despite the use of conventional chemotherapy; consequently, development of new therapeutic agents for melanoma is highly desirable. Here, we carried out a chemical genetic screen using a fission yeast phenotypic assay and showed that ACA-28, a synthetic derivative of 1'-acetoxychavicol acetate (ACA), which is a natural ginger compound, effectively inhibited the growth of melanoma cancer cells wherein ERK MAPK signaling is hyperactivated due to mutations in the upstream activating regulators...
May 9, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
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