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https://www.readbyqxmd.com/read/28927024/in-vitro-activities-of-enantiopure-and-racemic-1-acetoxychavicol-acetate-against-clinical-isolates-of-mycobacterium-tuberculosis
#1
Saradee Warit, Kamolchanok Rukseree, Therdsak Prammananan, Poonpilas Hongmanee, Pamaree Billamas, Sarinya Jaitrong, Angkana Chaiprasert, Birgit U Jaki, Guido F Pauli, Scott G Franzblau, Prasit Palittapongarnpim
In the process of evaluating the effect of several plant extracts against Mycobacterium tuberculosis using the Microplate Alamar Blue Assay (MABA), an extract of Thai herb Alpinia galanga rhizome and its major component, 1'-acetoxychavicol acetate (ACA), exhibited marked anti-tuberculosis activity. The minimal inhibition concentrations (MICs) of the S-enantiomer of ACA (S-ACA) against M. tuberculosis H37Ra ATCC 25177 and H37Rv ATCC 27294 strains were 0.2 µg/mL and 0.7 µg/mL, respectively. More than 95% of 100 drug-sensitive and 50 drug-resistant mycobacterial clinical isolates were inhibited by extracted S-ACA at 1...
September 18, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28910222/restricted-access-state-medicaid-coverage-of-sofosbuvir-hepatitis-c-treatment
#2
Marea B Tumber
Chronic hepatitis C (HCV) infection can persist for decades without symptoms. Many Americans are unaware of their infection status and are not receiving necessary care and treatment. This places them at greater risk for severe, even fatal, complications from the disease and increases the likelihood that they will transmit the virus to others. In late 2013, the Food and Drug Administration approved a direct acting antiviral drug called sofosbuvir to treat chronic HCV infection. Sofosbuvir is a highly effective, but very expensive, curative treatment for HCV...
January 2017: Journal of Legal Medicine
https://www.readbyqxmd.com/read/28906168/the-affordable-care-act-how-nixon-s-health-reform-proposal-became-democrats-albatross
#3
Steffie Woolhandler, David U Himmelstein
President Obama's signature health care reform, the Affordable Care Act (ACA), was passed in 2010 and fully implemented in 2014. Two years later, Republicans' attacks on the ACA as a failed reform helped fuel their recent electoral victory. The legislation significantly expanded insurance coverage. But it was built on, and fortified, private health insurance firms, and it accelerated the corporate takeover of hospitals and physicians' practices. This obeisance to corporate interests precluded making coverage universal or care affordable...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28895834/pennsylvania-s-individual-market-seems-to-be-slowly-stabilizing
#4
Robert Calandra
After premiums for 2017 increased, on average, by 32.5% over premiums for coverage in 2016, rate filings by insurers for 2018 show rates going up by only 8.8% over 2017 rates. But it could take at least five years for the ACA exchanges to shake all the bugs out.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28895833/tennessee-individual-market-just-barely-viable-for-now
#5
Timothy Kelley
Those who say the ACA is collapsing often point to Tennessee as evidence. And Gov. Bill Haslam has called it "ground zero" for plans pulling out of the ACA marketplaces. To give just one example, UnitedHealthcare left the individual market in the state at the end of 2016.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28895832/sunny-for-florida-blue-but-it-s-partly-cloudy-in-sunshine-state
#6
Susan Ladika
The ACA drove down the uninsured rate despite the lack of Medicare expansion, but major insurers have left the market. In some rural areas, Florida Blue is the only health plan in the game. Also in the mix: Consumers here usually pick the lowest-cost plan available.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28895821/acos-sit-like-gibraltar-in-rough-seas-of-change
#7
Robert Calandra
The ACO, a creature of the ACA that often gets confused with its progenitor, seems like it will survive-and maybe even thrive-in whatever healthscape emerges from the Republican anti-ACA push. But just what will happen to the various forms of the ACO that are now in place?
August 2017: Managed Care
https://www.readbyqxmd.com/read/28895819/paula-steiner-brings-her-blues-back-into-the-black
#8
Joseph Burns
The president and CEO of Chicago-based Health Care Service Corp. made tough decisions to raise premiums and narrow networks. But, at least for now, HCSC plans to stay in the ACA exchanges while other insurers are jumping ship.
August 2017: Managed Care
https://www.readbyqxmd.com/read/28895812/tom-price-the-aca-s-ardent-foe-pushes-for-repeal-and-replace-with-a-smile
#9
Howard Wolinsky
Price, 62, with pure white hair, rimless glasses, and an easy, slightly cherubic smile, comes across like a friendly, family doctor, not the ambitious, politically-minded orthopedic surgeon that he is. He calls the ACA "useless" because of the high deductibles.
August 2017: Managed Care
https://www.readbyqxmd.com/read/28894945/a-tabersonine-3-reductase-catharanthus-roseus-mutant-accumulates-vindoline-pathway-intermediates
#10
Alison Edge, Yang Qu, Michael L A E Easson, Antje M K Thamm, Kyung Hee Kim, Vincenzo De Luca
Monoterpenoid indole alkaloids (MIAs) have remarkable biological properties that have led to their medical uses for a variety of human diseases. Mutagenesis has been used to generate plants with new alkaloid profiles and a useful screen for rapid comparison of MIA profiles is described. The MIA mutants identified are useful for investigating MIA biosynthesis and for targeted production of these specialised metabolites. The Madagascar periwinkle (Catharanthus roseus) is the sole source of the dimeric anticancer monoterpenoid indole alkaloids (MIAs), 3',4'-anhydrovinblastine and derivatives, which are formed via the coupling of the MIAs, catharanthine and vindoline...
September 11, 2017: Planta
https://www.readbyqxmd.com/read/28893813/uninsured-primary-care-visit-disparities-under-the-affordable-care-act
#11
Heather Angier, Megan Hoopes, Miguel Marino, Nathalie Huguet, Elizabeth A Jacobs, John Heintzman, Heather Holderness, Carlyn M Hood, Jennifer E DeVoe
PURPOSE: Health insurance coverage affects a patient's ability to access optimal care, the percentage of insured patients on a clinic's panel has an impact on the clinic's ability to provide needed health care services, and there are racial and ethnic disparities in coverage in the United States. Thus, we aimed to assess changes in insurance coverage at community health center (CHC) visits after the Patient Protection and Affordable Care Act (ACA) Medicaid expansion by race and ethnicity...
September 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28887601/is-there-a-role-for-epithelial-mesenchymal-transition-in-adrenocortical-tumors
#12
Daniel Bulzico, Paulo Antônio Silvestre de Faria, Camila Bravo Maia, Marcela Pessoa de Paula, Davi Coe Torres, Gerson Moura Ferreira, Bruno Ricardo Barreto Pires, Rocio Hassan, Eliana Abdelhay, Mario Vaisman, Leonardo Vieira Neto
PURPOSE: Epithelial-mesenchymal transition (EMT) is a biological dynamic process by which epithelial cells lose their epithelial phenotype and acquire mesenchymal invasive and migratory characteristics. This has been postulated as an essential step during cancer progression and metastasis. Although this is well described in other tumors, the role of EMT in adrenocortical tumors (ACT) has yet to be addressed. METHODS: The aim of this study was to evaluate the expression of EMT markers e-cadherin, vimentin, and fibronectin, along with EMT-transcription factors (EMT-TFs), TWIST1, SIP1, and SNAIL in 24 adrenocortical carcinoma (ACC), 19 adrenocortical adenomas (ACA), 27 childhood-onset adrenocortical tumors (CAT), and 12 normal adrenal glands...
September 8, 2017: Endocrine
https://www.readbyqxmd.com/read/28887343/population-health-and-medicine-policy-and-financial-drivers
#13
Jill E Lavigne, Jack Brown, Gary R Matzke
PURPOSE: The financial and policy levers of population health and potential opportunities for pharmacists are described. SUMMARY: Three long-standing problems drive the focus on population health: (1) the United States suffers far worse population health outcomes compared with those of other developed nations that spend significantly less on healthcare, (2) the U.S. healthcare system's focus on "sick care" fails to address upstream prevention and population health improvement, and (3) financial incentives for healthcare delivery are poorly aligned with improvements in population health outcomes...
September 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28885865/changes-in-insurance-coverage-and-stage-at-diagnosis-among-nonelderly-patients-with-cancer-after-the-affordable-care-act
#14
Ahmedin Jemal, Chun Chieh Lin, Amy J Davidoff, Xuesong Han
Purpose To examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with newly diagnosed cancer after the Affordable Care Act (ACA). Patients and Methods By using the National Cancer Data Base, we estimated absolute change (APC) and relative change in percent uninsured among patients with newly diagnosed cancer age 18 to 64 years between 2011 to the third quarter of 2013 (pre-ACA implementation) and the second to fourth quarter of 2014 (post-ACA) in Medicaid expansion and nonexpansion states by family income level...
September 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28885028/a-numerical-calculation-method-of-apparent-contact-angles-on-heterogenous-double-roughness-surfaces
#15
Jian Dong, Yanli Jin, He Dong, Li Sun
Double-roughness surfaces can be used to mimic lotus surfaces. The apparent contact angles (ACAs) of droplets on these surfaces were first calculated by Herminghaus. Then Patankar utilized pillar model to improve the Herminghaus approach and put forward the formulae for ACAs calculation of the homogeneous double-roughness surfaces where the dual-scale structures and the bases were the same wettable materials. In this paper, we propose a numerical calculation method of ACAs on the heterogenous double-roughness surfaces where the dual-scale structures and the bases are made of different wettable materials...
September 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28884963/identification-of-hla-b-58-01-21-a-novel-allele-in-a-korean-individual
#16
Jun Hyung Lee, Hyun-Jung Choi, Soo-Hyun Kim, Myung-Geun Shin
statement B*58:01:21 has a single nucleotide change, c.264A>G (ACA→ACG at codon 88) compared to B*58:01:01:01.
September 8, 2017: HLA
https://www.readbyqxmd.com/read/28880062/following-the-aca-repeal-and-replace-effort-where-does-the-u-s-stand-on-insurance-coverage-findings-from-the-commonwealth-fund-affordable-care-act-tracking-survey-march-june-2017
#17
Sara R Collins, Munira Z Gunja, Michelle M Doty
Issue: After Congress's failure to repeal and replace the Affordable Care Act, some policy leaders are calling for bipartisan approaches to address weaknesses in the law’s coverage expansions. To do this, policymakers will need data about trends in insurance coverage, reasons why people remain uninsured, and consumer perceptions of affordability. Goal: To examine U.S. trends in insurance coverage and the demographics of the remaining uninsured population, as well as affordability and satisfaction among adults with marketplace and Medicaid coverage...
September 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/28879070/trends-in-breast-and-colorectal-cancer-screening-among-u-s-adults-by-race-healthcare-coverage-and-ses-before-during-and-after-the-great-recession
#18
Taylor E Wyatt, Vikash Pernenkil, Tomi F Akinyemiju
The aim of this study is examine trends in breast and colorectal cancer screening in the U.S. by race, healthcare coverage, and socio-economic status (SES) before the Great Recession (2003-2005), during the recession (2007-2009), and post-recession/Affordable Care Act (ACA) period (2010 - 2012). Data on a representative sample of U.S. adults was obtained from the Behavioral Risk Factor Surveillance System (BRFSS). Breast and colorectal cancer screening were defined in line with U.S. Preventative Services Task Force guidelines, and survey weighted statistical methods were utilized to analyze trends in cancer screening among 1,858,572 BRFSS participants...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28879066/obstetricians-and-gynecologists-opinions-about-the-affordable-care-act-and-their-expectations-about-how-it-will-impact-their-practice
#19
Britta L Anderson, Ellen Peters, Michael F Fialkow, Laura H Taouk, Jay Schulkin
As the primary healthcare providers for women, obstetrician-gynecologists' (OB/GYNs) experiences with and opinions about the Affordable Care Act (ACA) are important to understand. An online survey was sent to 1000 randomly selected OB/GYNs who were members of the American College of Obstetricians and Gynecologists (ACOG) in 2014. Of those, 523 opened the email and 163 responded (31% participation rate). Data were collected August 2014-October 2014 and analyzed in 2015-2016. Support for the ACA was widely distributed, with the largest subset of the sample (about 21%) in the "very supportive" category...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28874932/emergency-department-use-across-88-small-areas-after-affordable-care-act-implementation-in-illinois
#20
Joe Feinglass, Andrew J Cooper, Kelsey Rydland, Emilie S Powell, Megan McHugh, Raymond Kang, Scott M Dresden
INTRODUCTION: This study analyzes changes in hospital emergency department (ED) visit rates before and after the 2014 Affordable Care Act (ACA) insurance expansions in Illinois. We compare the association between population insurance status change and ED visit rate change between a 24-month (2012-2013) pre-ACA period and a 24-month post-ACA (2014-2015) period across 88 socioeconomically diverse areas of Illinois. METHODS: We used annual American Community Survey estimates for 2012-2015 to obtain insurance status changes for uninsured, private, Medicaid, and Medicare (disability) populations of 88 Illinois Public Use Micro Areas (PUMAs), areas with a mean of about 90,000 age 18-64 residents...
August 2017: Western Journal of Emergency Medicine
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