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https://www.readbyqxmd.com/read/29349672/sta-aca-bypass-using-the-ipsilateral-free-sta-graft-as-an-interposition-graft-and-a3-a3-anastomosis-for-treatment-of-bilateral-aca-steno-occlusive-ischemia
#1
Tetsuyoshi Horiuchi, Shunsuke Ichinose, Masahiro Agata, Kiyoshi Ito, Kazuhiro Hongo
BACKGROUND: Anterior cerebral artery (ACA)-related ischemia is a rare entity in patients with atherosclerosis. Some surgical treatments are reported to date. METHOD: We present the modification of intracranial-intracranial and intracranial-extracranial bypasses for symptomatic bilateral ACA steno-occlusive disease. The A3-A3 bypass followed by the superficial temporal artery-ACA bypass using the ipsilateral free superficial temporal artery graft is useful without harvesting of the radial artery...
January 18, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29345995/the-effects-of-household-medical-expenditures-on-income-inequality-in-the-united-states
#2
Andrea S Christopher, David U Himmelstein, Steffie Woolhandler, Danny McCormick
OBJECTIVES: To assess the effect of households' outlays for medical expenditures on income inequality and changes since the implementation of the Affordable Care Act (ACA). METHODS: We analyzed data from the US Current Population Surveys for calendar years 2010 through 2014. We calculated the Gini index of income inequality before and after subtracting households' medical outlays (including insurance premiums and out-of-pocket costs) from income, the financial burden of medical outlays for each income decile, and the number of individuals pushed below poverty by medical outlays...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29342379/elimination-of-cost-sharing-for-screening-mammography-in-medicare-advantage-plans
#3
Amal N Trivedi, Bryan Leyva, Yoojin Lee, Orestis A Panagiotou, Issa J Dahabreh
BACKGROUND: The Affordable Care Act (ACA) required most insurers and the Medicare program to eliminate cost sharing for screening mammography. METHODS: We conducted a difference-in-differences study of biennial screening mammography among 15,085 women 65 to 74 years of age in 24 Medicare Advantage plans that eliminated cost sharing to provide full coverage for screening mammography, as compared with 52,035 women in 48 matched control plans that had and maintained full coverage...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29340707/vrk1-and-aurkb-form-a-complex-that-cross-inhibit-their-kinase-activity-and-the-phosphorylation-of-histone-h3-in-the-progression-of-mitosis
#4
David S Moura, Ignacio Campillo-Marcos, Marta Vázquez-Cedeira, Pedro A Lazo
Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis. Vaccinia-related kinase 1 (VRK1) and Aurora B (AURKB) are two nuclear kinases involved in different steps of cell division. We have studied whether there is any functional connection between these two nuclear kinases, which phosphorylate histone H3 in Thr3 and Ser10, respectively. VRK1 and AURKB are able to form a stable protein complex, which represents only a minor subpopulation of each kinase within the cell and is detected following nocodazole release...
January 16, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29336413/erratum-comparison-of-the-renoprotective-effect-of-dexmedetomidine-and-dopamine-in-high-risk-renal-patients-undergoing-cardiac-surgery-a-double-blind-randomized-study
#5
(no author information available yet)
[This corrects the article DOI: 10.4103/aca.ACA_57_17.].
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29335798/3d-morphological-change-of-skull-base-and-fronto-temporal-soft-tissue-in-the-patients-with-unicoronal-craniosynostosis-after-fronto-orbital-advancement
#6
Bin Yang, Jian Ni, Binghang Li
PURPOSE: This study aims to comprehensively evaluate the deformation of the skull base and fronto-temporal soft tissue in the patients with anterior plagiocephaly over 1 year of age by three-dimensional (3D) imaging after fronto-orbital advancement (FOA). METHODS: We quantitatively analyzed the surgical results and outcome of FOA performed in 10 patients with anterior plagiocephaly. The measurements of the skull base and fronto-temporal soft tissue were performed based on 3D computed tomography (CT) scan...
January 15, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29332161/the-computed-tomography-adrenal-wash-out-analysis-properly-classifies-cortisol-secreting-adrenocortical-adenomas
#7
Anne-Laure Humbert, Guillaume Lecoanet, Sophie Moog, Fehd Bouderraoui, Laurent Bresler, Jean-Michel Vignaud, Elodie Chevalier, Laurent Brunaud, Marc Klein, Thomas Cuny
PURPOSE: Adrenocortical lesions are characterized through imaging, hormonal and histopathological analysis. Our aim was to compare the radiological features of adrenocortical lesions with their cortisol-secreting status and histopathological Weiss score. METHODS: Seventy five patients operated between 2004 and 2016 in the University Hospital of Nancy for either adrenocortical carcinomas (ACC) or adrenocortical adenomas (ACA) were enrolled in this study. We collected cortisol parameters, Computed Tomography (CT) scans (unenhanced density, wash-out (WO) analysis) and 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) datas...
January 13, 2018: Endocrine
https://www.readbyqxmd.com/read/29331789/anticonvulsant-activities-of-%C3%AE-asaronol-e-3-hydroxyasarone-an-active-constituent-derived-from-%C3%AE-asarone
#8
Xirui He, Yajun Bai, Min Zeng, Zefeng Zhao, Qiang Zhang, Ning Xu, Fanggang Qin, Xiaoyang Wei, Meimei Zhao, Ni Wu, Zehua Li, Yajun Zhang, Tai-Ping Fan, Xiaohui Zheng
BACKGROUND: Epilepsy is one of chronic neurological disorders that affects 0.5-1.0% of the world's population during their lifetime. There is a still significant need to develop novel anticonvulsant drugs that possess superior efficacy, broad spectrum of activities and good safety profile. METHODS: α-Asaronol and two current antiseizure drugs (α-asarone and carbamazepine (CBZ)) were assessed by in vivo anticonvulsant screening with the three most employed standard animal seizure models, including maximal electroshock seizure (MES), subcutaneous injection-pentylenetetrazole (PTZ)-induced seizures and 3-mercaptopropionic acid (3-MP)-induced seizures in mice...
August 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29329859/effect-of-high-pressure-on-structural-modifications-and-enzymatic-activity-of-a-purified-x-prolyl-dipeptidyl-aminopeptidase-from-streptococcus-thermophilus
#9
M Giannoglou, Z Alexandrakis, Ph Stavros, G Katsaros, P Katapodis, G Nounesis, P Taoukis
PepX aminopeptidase from Streptococcus thermophilus ACA DC 0022, used in Greek Feta cheese manufacturing, was purified. PepX comprises two subunits of equal molecular mass estimated, using SDS-PAGE and native-PAGE electrophoresis, to be 86 kDa. The effects of high pressure processing (100-450 MPa, combined with 20-40 °C) on purified PepX activity and structure were studied. Activation of the enzyme was observed after processing at 100-200 MPa and 20-30 °C. More intense processing conditions led to enzyme inactivation...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328879/modeling-health-care-expenditures-and-use
#10
Partha Deb, Edward C Norton
Health care expenditures and use are challenging to model because these dependent variables typically have distributions that are skewed with a large mass at zero. In this article, we describe estimation and interpretation of the effects of a natural experiment using two classes of nonlinear statistical models: one for health care expenditures and the other for counts of health care use. We extend prior analyses to test the effect of the ACA's young adult expansion on three different outcomes: total health care expenditures, office-based visits, and emergency department visits...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29327383/large-scale-noniridescent-structural-color-printing-enabled-by-infiltration-driven-nonequilibrium-colloidal-assembly
#11
Ling Bai, Van Cuong Mai, Yun Lim, Shuai Hou, Helmuth Möhwald, Hongwei Duan
Structural colors originating from interaction of light with intricately arranged micro-/nanostructures have stimulated considerable interest because of their inherent photostability and energy efficiency. In particular, noniridescent structural color with wide viewing angle has been receiving increasing attention recently. However, no method is yet available for rapid and large-scale fabrication of full-spectrum structural color patterns with wide viewing angles. Here, infiltration-driven nonequilibrium assembly of colloidal particles on liquid-permeable and particle-excluding substrates is demonstrated to direct the particles to form amorphous colloidal arrays (ACAs) within milliseconds...
January 12, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29325899/do-ketone-bodies-mediate-the-anti-seizure-effects-of-the-ketogenic-diet
#12
REVIEW
Timothy A Simeone, Kristina A Simeone, Carl E Stafstrom, Jong M Rho
Although the mechanisms underlying the anti-seizure effects of the high-fat ketogenic diet (KD) remain unclear, a long-standing question has been whether ketone bodies (i.e., beta-hydroxybutyrate [BHB], acetoacetate [ACA] and acetone), either alone or in combination, contribute mechanistically. The traditional belief has been that while ketone bodies reflect enhanced fatty acid oxidation and a general shift toward intermediary metabolism, they are not likely to be the key mediators of the KD's clinical effects, as blood levels of BHB do not correlate consistently with improved seizure control...
January 8, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29324900/internal-carotid-artery-stenosis-a-novel-surgical-model-for-moyamoya-syndrome
#13
Jill M Roberts, Michael E Maniskas, Justin F Fraser, Gregory J Bix
Moyamoya is a cerebrovascular disorder characterized by progressive stenosis of the intracranial internal carotid arteries. There are two forms: Disease and Syndrome, with each characterized by the sub-population it affects. Moyamoya syndrome (MMS) is more prominent in adults in their 20's-40's, and is often associated with autoimmune diseases. Currently, there are no surgical models for inducing moyamoya syndrome, so our aim was to develop a new animal model to study this relatively unknown cerebrovascular disease...
2018: PloS One
https://www.readbyqxmd.com/read/29324896/correlation-of-the-anterior-ocular-segment-biometry-with-hba1c-level-in-type-2-diabetes-mellitus-patients
#14
Abd-Rashid Suraida, Mohtar Ibrahim, Embong Zunaina
OBJECTIVES: To compare the anterior ocular segment biometry among Type 2 diabetes mellitus (DM) with no diabetic retinopathy (DR) and non-proliferative diabetic retinopathy (NPDR), and to evaluate the correlation of anterior ocular segment biometry with HbA1c level. METHODS: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia, Kelantan from November 2013 till May 2016 among Type 2 DM patients (DM with no DR and DM with NPDR). The patients were evaluated for anterior ocular segment biometry [central corneal thickness (CCT), anterior chamber width (ACW), angle opening distance (AOD) and anterior chamber angle (ACA)] by using Anterior Segment Optical Coherence Tomography (AS-OCT)...
2018: PloS One
https://www.readbyqxmd.com/read/29320776/v600e-braf-versus-non-v600e-braf-mutated-lung-adenocarcinomas-cytomorphology-histology-coexistence-of-other-driver-mutations-and-patient-characteristics
#15
Kevan J Salimian, Roghayeh Fazeli, Gang Zheng, David Ettinger, Zahra Maleki
OBJECTIVES: We analyzed the morphologic features and clinical characteristics of lung adenocarcinomas (ACAs) harboring mutated BRAF. STUDY DESIGN: A review of the histology/cytology of BRAF-mutated lung ACAs was performed at the Johns Hopkins Hospital from January 1, 2013, to January 1, 2015. Patient demographics, clinical history, and ACA morphology were assessed. RESULTS: Thirty-six cases were identified with a median age of 66 years (range 44-87), 58% (21/36) were female, and 94% (34/36) were current or former smokers...
January 11, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29317552/validation-and-refinement-of-the-age-comorbidities-and-albumin-index-in-elderly-patients-with-diffuse-large-b-cell-lymphoma-an-effective-tool-for-comprehensive-geriatric-assessment
#16
Hui Liu, Chun-Li Zhang, Ru Feng, Jiang-Tao Li, Yuan Tian, Ting Wang
BACKGROUND: We aimed to validate and refine the Age, Comorbidities, and Albumin (ACA) index in elderly Chinese patients with diffuse large B-cell lymphoma (DLBCL) and propose a more effective method for comprehensive geriatric assessment (CGA). MATERIALS AND METHODS: Patients ≥65 years of age who had been diagnosed with de novo DLBCL in the Institute of Hematology, Beijing Hospital, were screened for eligibility (n = 99). RESULTS: Based on the ACA index, 39, 31, 26, and 3 patients were categorized into the "excellent," "good," "moderate," and "poor" groups, respectively...
January 9, 2018: Oncologist
https://www.readbyqxmd.com/read/29309224/community-benefit-spending-by-tax-exempt-hospitals-changed-little-after-aca
#17
Gary J Young, Stephen Flaherty, E David Zepeda, Simone Rauscher Singh, Geri Rosen Cramer
Provisions of the Affordable Care Act (ACA) encouraged tax-exempt hospitals to invest broadly in community health benefits. Four years after the ACA's enactment, hospitals had increased their average spending for all community benefits by 0.5 percentage point, from 7.6 percent of their operating expenses in 2010 to 8.1 percent in 2014.
January 2018: Health Affairs
https://www.readbyqxmd.com/read/29309219/understanding-the-relationship-between-medicaid-expansions-and-hospital-closures
#18
Richard C Lindrooth, Marcelo C Perraillon, Rose Y Hardy, Gregory J Tung
Decisions by states about whether to expand Medicaid under the Affordable Care Act (ACA) have implications for hospitals' financial health. We hypothesized that Medicaid expansion of eligibility for childless adults prevents hospital closures because increased Medicaid coverage for previously uninsured people reduces uncompensated care expenditures and strengthens hospitals' financial position. We tested this hypothesis using data for the period 2008-16 on hospital closures and financial performance. We found that the ACA's Medicaid expansion was associated with improved hospital financial performance and substantially lower likelihoods of closure, especially in rural markets and counties with large numbers of uninsured adults before Medicaid expansion...
January 2018: Health Affairs
https://www.readbyqxmd.com/read/29306510/protective-effects-of-artemisia-campestris-extract-against-gastric-acid-reflux-induced-esophageal-mucosa-injuries
#19
Mohamed-Amine Jabri, Haifa Tounsi, Afifa Abdellaoui, Lamjed Marzouki, Hichem Sebai
Artemisia campestris L. has been widely used in alternative medicine to treat digestive system diseases, particularly gastroesophageal disorders. In the present investigation, we studied the putative protective effect of Artemisia campestris aqueous extract (ACAE) against gastro-esophageal reflux (GER)-induced esophagitis in rats. The experimental ophagitis was induced by the ligation of the pylorus as well as the junction between the forestomach and the corpus. We firstly found that ACAE administration at 100, 200 and 400 mg/kg, b...
January 2, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29302881/could-pay-for-performance-worsen-health-disparities
#20
Mubeen Shakir, Katrina Armstrong, Jason H Wasfy
Pay-for-performance (P4P) has become a prominent component of health care funding in the Affordable Care Act (ACA) era. Although the ACA's future remains unclear, these programs receive bipartisan support and will likely continue to be a part of payment policies. At the same time, racial and class disparities remain among the most pressing of the many challenges facing the US health system. We review evidence of the effects of P4P on disparities at the population and individual levels. Providers caring for predominantly minority patients or those with lower socioeconomic status are known to have poorer quality metrics...
January 4, 2018: Journal of General Internal Medicine
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