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https://www.readbyqxmd.com/read/28743017/development-pubertal-hormones-meet-the-adolescent-brain
#1
Cheryl L Sisk
At the onset of puberty, ovarian hormones increase inhibitory tone in the prefrontal cortex. Inhibitory maturation is a hallmark of the initiation of developmental windows of neural plasticity; pubertal hormones may trigger the opening of an adolescent critical period for experience-dependent rewiring of circuits underlying executive function.
July 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28742076/altered-neurite-morphology-and-cholinergic-function-of-induced-pluripotent-stem-cell-derived-neurons-from-a-patient-with-kleefstra-syndrome-and-autism
#2
J Nagy, J Kobolák, S Berzsenyi, Z Ábrahám, H X Avci, I Bock, Z Bekes, B Hodoscsek, A Chandrasekaran, A Téglási, P Dezső, B Koványi, E T Vörös, L Fodor, T Szél, K Németh, A Balázs, A Dinnyés, B Lendvai, G Lévay, V Román
The aim of the present study was to establish an in vitro Kleefstra syndrome (KS) disease model using the human induced pluripotent stem cell (hiPSC) technology. Previously, an autism spectrum disorder (ASD) patient with Kleefstra syndrome (KS-ASD) carrying a deleterious premature termination codon mutation in the EHMT1 gene was identified. Patient specific hiPSCs generated from peripheral blood mononuclear cells of the KS-ASD patient were differentiated into post-mitotic cortical neurons. Lower levels of EHMT1 mRNA as well as protein expression were confirmed in these cells...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28741445/results-of-endoscopic-cartilage-tympanoplasty-procedure-with-limited-tympanomeatal-flap-incision
#3
Isa Kaya, Goksel Turhal, Arin Ozturk, Sercan Gode, Cem Bilgen, Tayfun Kirazli
OBJECTIVE: The aim of this study was to evaluate the outcomes of this minimally invasive tympanomeatal incision technique performed during endoscopic transcanal cartilage tympanoplasty. STUDY DESIGN: Prospective clinical study. METHODS: Eighty-seven patients (87 ears) who had TM perforation with noncomplicated COM were included. All of the patients were operated with the endoscopic transcanal cartilage tympanoplasty technique. All of the data were prospectively collected...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28741424/validity-of-the-breakup-strategies-questionnaire-in-korea-exploratory-structural-equation-modeling-and-rasch-s-modeling
#4
Dong-Gwi Lee, Harim Sohn, Byeong Hoon Bae, Yoorim Song
This study examines the validity of the Korean implementation of the Breakup Strategies Questionnaire. In Study 1, the construct validity of the Breakup Strategies Questionnaire was explored with 292 Korean undergraduate students. Exploratory Structural Equation Modeling and Rasch's Modeling suggest 30 items with four factors (Avoidance/withdrawal, Positive tone/self-blame, Open confrontation, and Indirect manipulation) and five points in response. Study 2 with 174 Korean undergraduate students suggested potential gender differences in breakup strategy dimensions and provided support for concurrent validity with a measure of personal styles of coping as well as discriminant validity with social desirability...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28738727/the-home-as-ethos-of-caring-a-concept-determination
#5
Yvonne Hilli, Katie Eriksson
BACKGROUND: Within nursing, the concepts of home and homelike have been used indiscriminately to describe characteristics of healthcare settings that resemble a home more than an institution. OBJECTIVES: The aim of this study was to investigate the concept of home ( hem in Swedish). The main questions were as follows: What does the concept of home entail etymologically and semantically? Of what significance is the meaning of the concept to caring science and nursing? DESIGN AND METHODS: This study had a qualitative design with a hermeneutical approach guided by Gadamer...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28738342/a-succinct-history-of-sleep-medicine
#6
Leh-Kiong Anne Huon, Christian Guilleminault
Although sleep and sleep disorders have been studied for centuries, it was the development of sophisticated tools to monitor eye movements, brain waves, and muscle tone in the mid-20th century that led to modern sleep research. These tools allowed neuroscientists to distinguish between different "states" or "phases" of sleep, and to relate these findings to sleep disorders. This review chronicles the groundbreaking work of the pioneers in this field, and the impact their findings have had on patients today.
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28737551/vibrotactile-thresholds-on-the-mastoid-and-forehead-position-of-deaf-patients-using-radioear-b71-and-b81
#7
Karl-Johan Fredén Jansson, Bo Håkansson, Sabine Reinfeldt, Laura Fröhlich, Torsten Rahne
OBJECTIVES: The main objective of this study was to measure the vibrotactile thresholds on the mastoid process and forehead positions using patients with bilateral deafness and to compare the results from the two bone conduction vibrators Radioear B71 and B81. DESIGN: There is a possibility that the vibrotactile sensation on the skin makes it difficult to discriminate between sound and vibration. The risk is highest for patients who have bone conduction hearing thresholds in proximity to or worse than their vibrotactile thresholds...
July 21, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28737531/potential-causes-of-elevated-ree-following-high-intensity-exercise
#8
Gary R Hunter, Douglas R Moellering, Stephen J Carter, Barbara A Gower, Marcas M Bamman, Lyndsey M Hornbuckle, Eric P Plaisance, Gordon Fisher
INTRODUCTION: Resting energy expenditure (REE) increases following intense exercise; however, little is known concerning mechanisms. PURPOSE: Determine effects of a single bout of moderate-intensity continuous aerobic exercise (MIC), or high intensity interval exercise (HII) on REE under energy balance conditions. METHODS: Thirty-three untrained premenopausal women were evaluated at baseline, after 8-16 weeks of training, 22 hours following either MIC (50% peak VO2) or HII (84% peak VO2)...
July 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28737283/prevalence-of-hearing-and-vestibular-loss-in-cystic-fibrosis-patients-exposed-to-aminoglycosides
#9
Jaynee A Handelsman, Samya Z Nasr, Crystal Pitts, William M King
AIM: Cystic Fibrosis (CF) patients frequently use aminoglycosides (AGS) to treat CF exacerbation due to colonization with Pseudomonas aeruginosa. Although AGS can cause vestibular and auditory sensory losses that can negatively impact quality of life, little is known about the prevalence of vestibular loss in this population. The aim of this study was to determine the prevalence of hearing loss and/or vestibular dysfunction in CF patients treated with AGS. METHODS: The relationship between hearing status and vestibular status was also investigated...
July 24, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28737245/exteroceptive-stimuli-override-interoceptive-state-in-reaction-time-control
#10
Xiao Yang, J Richard Jennings, Bruce H Friedman
The processing of reaction time (RT) stimulus is modulated by its timing relative to the cardiac cycle. RT stimulus processing is also influenced by task-irrelevant stimuli: a sensory stimulus speeds RT when it accompanies a cue to react in another sensory modality. Different theories have been proposed to explain this accessory stimulus effect (ASE). However, it is unclear whether the ASE interacts with the cardiac timing effect. In the present study, the relationship of the ASE, cardiac timing, and stimulus valence was examined...
July 24, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28736944/short-term-acipimox-treatment-is-associated-with-decreased-cardiac-parasympathetic-modulation
#11
Esben Thyssen Vestergaard, Simon Lebech Cichosz, Niels Møller, Jens Otto Lunde Jørgensen, Jesper Fleischer
AIM: The nicotinic acid analogue acipimox is an anti-lipolytic agent, which acutely inhibits lipolysis, and suppresses systemic levels of free fatty acids (FFA) and improves insulin sensitivity in obese patients. These effects of acipimox are transient due to a counter-regulatory increase in growth hormone (GH) levels that reverse the anti-lipolytic effect of acipimox. Hypopituitary patients constitute a viable model to study the GH-independent effects of acipimox and the impact of isolated changes in FFA concentrations and insulin sensitivity on parasympathetic nervous activity...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28736326/tone-inhibiting-insoles-enhance-the-reciprocal-inhibition-of-ankle-plantarflexors-of-post-stroke-hemiparetic-subjects-an-electromyographic-study
#12
Nobushige Takahashi, Hidetoshi Takahashi, Osamu Takahashi, Ryosuke Ushijima, Rie Umebayashi, Junji Nishikawa, Yasutomo Okajima
BACKGROUND: Spasticity is a common sequela of upper motor neuron pathology, such as cerebrovascular diseases and cerebral palsy. Intervention for spasticity of the ankle plantarflexors in physical therapy may include tone-inhibiting casting and/or orthoses for the ankle and foot. However, the physiological mechanism of tone reduction by such orthoses remains unclarified. OBJECTIVE: To investigate the electrophysiologic effects of tone-inhibiting insoles in stroke subjects with hemiparesis by measuring changes in reciprocal Ia inhibition (RI) in the ankle plantarflexor...
July 20, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28736325/traumatic-neuropathy-of-the-trigeminal-nerve-in-a-college-trumpet-player-a-case-report
#13
Jeremy Lee Stanek, Kevin Donserm Komes
A 20-year-old college trumpet player presented with a 3-month history of upper lip numbness and worsening playing ability after a marching band performance. Examination demonstrated anesthesia of the upper lip following the borders of the trumpet mouthpiece. While playing, the patient had poor range and an airy tone quality. A prescription of complete embouchure rest for 6 weeks and a tailored return to play regimen resulted in resolution of upper lip numbness and improved trumpet playing. Neuropathy of the lip in a brass player is uncommon but highlights the uniqueness of injuries that may be sustained by performing artists...
July 20, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28735495/neuroanatomical-and-resting-state-eeg-power-correlates-of-central-hearing-loss-in-older-adults
#14
Nathalie Giroud, Sarah Hirsiger, Raphaela Muri, Andrea Kegel, Norbert Dillier, Martin Meyer
To gain more insight into central hearing loss, we investigated the relationship between cortical thickness and surface area, speech-relevant resting state EEG power, and above-threshold auditory measures in older adults and younger controls. Twenty-three older adults and 13 younger controls were tested with an adaptive auditory test battery to measure not only traditional pure-tone thresholds, but also above individual thresholds of temporal and spectral processing. The participants' speech recognition in noise (SiN) was evaluated, and a T1-weighted MRI image obtained for each participant...
July 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28735101/electrophysiological-correlates-of-speaker-segregation-and-foreground-background-selection-in-ambiguous-listening-situations
#15
Katharina Gandras, Sabine Grimm, Alexandra Bendixen
In everyday listening environments, a main task for our auditory system is to follow one out of multiple speakers talking simultaneously. The present study was designed to find electrophysiological indicators of two central processes involved - segregating the speech mixture into distinct speech sequences corresponding to the two speakers, and then attending to one of the speech sequences. We generated multistable speech stimuli that were set up to create ambiguity as to whether only one or two speakers are talking...
July 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28734940/role-of-orbitofrontal-sulcogyral-pattern-on-lifetime-cannabis-use-and-depressive-symptoms
#16
Yann Chye, Nadia Solowij, Eleni P Ganella, Chao Suo, Murat Yücel, Albert Batalla, Janna Cousijn, Anna E Goudriaan, Rocio Martin-Santos, Sarah Whittle, Cali F Bartholomeusz, Valentina Lorenzetti
Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confer risk for earlier onset of cannabis (CB) use and greater use in later life. The OFC sulcogyral pattern may therefore be a stable trait marker in understanding individual differences in substance-use vulnerability and associated affective disturbances in users...
July 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28734228/effect-of-education-on-ability-of-ai-professionals-and-herd-owner-inseminators-to-detect-cows-not-in-oestrus-and-its-relation-with-progesterone-concentration-on-day-of-re-insemination
#17
K Vartia, J Taponen, J Heikkinen, H Lindeberg
The effect of training background of persons performing artificial insemination (AI) (herd-owner inseminators (OWNER), AI technicians (AI-T), and fertility consultants (FC)) on pregnancy rate and their ability to detect cows not in oestrus were studied. A total of 1584 re-AI occasions on 754 dairy farms were included. Milk samples for progesterone (P4) analysis in all cases were collected, as were data on the herd, previous breeding attempts, oestrous signs, uterine tone, slipperiness of cervix, and co-operation of the cow...
July 13, 2017: Theriogenology
https://www.readbyqxmd.com/read/28733893/effects-of-new-generation-tmem16a-inhibitors-on-calcium-activated-chloride-currents-in-rabbit-urethral-interstitial-cells-of-cajal
#18
Stephen Fedigan, Eamonn Bradley, Timothy Webb, Roddy J Large, Mark A Hollywood, Keith D Thornbury, Noel G McHale, Gerard P Sergeant
Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca(2+)-activated Cl(-) currents (I ClCa) that are important for the development of urethral tone. Here, we examined if TMEM16A (ANO1) contributed to this activity by examining the effect of "new-generation" TMEM16A inhibitors, CACCinh-A01 and T16Ainh-A01, on I ClCa recorded from freshly isolated rabbit urethral ICC (RUICC) and on contractions of intact strips of rabbit urethra smooth muscle. Real-time quantitative PCR experiments demonstrated that TMEM16A was highly expressed in rabbit urethra smooth muscle, in comparison to TMEM16B and TMEM16F...
July 21, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28733831/nocturnal-blood-pressure-dipping-is-abolished-in-old-elderly-hospitalized-patients
#19
Francesco Salvo, Chiara Lonati, Michele Berardi, Andrea Riccardo Errani, Carlo Lorenzo Muzzulini, Alberto Morganti
INTRODUCTION: During sleep there is reduction of blood pressure (BP) caused by a decrease of the sympathetic nervous tone. This nocturnal "dipping" phenomenon, assessable with ambulatory blood pressure monitoring (ABPM), is blunted with increasing age. AIM: To assess the effect of hospitalization on night-time BP fall in old-elderly patients. METHODS: We analysed 78 ABPM of old-elderly hospitalized patients (mean age 91 ± 0.5 years) and those of 18 outpatients as control group...
July 22, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28733803/vocoder-simulations-explain-complex-pitch-perception-limitations-experienced-by-cochlear-implant-users
#20
Anahita H Mehta, Andrew J Oxenham
Pitch plays a crucial role in speech and music, but is highly degraded for people with cochlear implants, leading to severe communication challenges in noisy environments. Pitch is determined primarily by the first few spectrally resolved harmonics of a tone. In implants, access to this pitch is limited by poor spectral resolution, due to the limited number of channels and interactions between adjacent channels. Here we used noise-vocoder simulations to explore how many channels, and how little channel interaction, are required to elicit pitch...
July 21, 2017: Journal of the Association for Research in Otolaryngology: JARO
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