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https://www.readbyqxmd.com/read/29156225/differences-between-auditory-frequency-following-responses-and-onset-responses-intracranial-evidence-from-rat-inferior-colliculus
#1
Qian Wang, Liang Li
A periodic sound, such as a pure tone, evokes both transient onset field-potential responses and sustained frequency-following responses (FFRs) in the auditory midbrain, the inferior colliculus (IC). It is not clear whether the two types of responses are based on the same or different neural substrates. Although it has been assumed that FFRs are based on phase locking to the periodic sound, the evidence showing the direct relationship between the FFR amplitude and the phase-locking strength is still lacking...
November 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/29156097/4-aminopyridine-a-pan-kv-channel-inhibitor-that-enhances-kv7-4-currents-and-inhibits-noradrenaline-mediated-contraction-of-rat-mesenteric-small-arteries
#2
Makhala M Khammy, Sukhan Kim, Bo H Bentzen, Soojung Lee, Inyeoung Choi, Christian Aalkjaer, Thomas A Jepps
BACKGROUND AND PURPOSE: Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4-aminopyridine (4-AP) is considered a broad inhibitor of voltage-gated potassium (KV ) channels, with little inhibitory effect on Kv7 family members at millimolar concentrations. However, the effect of 4-AP on Kv7 channels has not been systematically studied. The aim of this study was to investigate the pharmacological activity of 4-AP on Kv7.4 and Kv7.5 channels and characterise the effect of 4-AP on rat resistance arteries...
November 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29155297/divergent-profile-between-hypothalamic-and-plasmatic-aminopeptidase-activities-in-wky-and-shr-influence-of-beta-adrenergic-blockade
#3
Isabel Prieto, Ana B Segarra, Marc de Gasparo, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez
AIMS: Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) differ in their renin-angiotensin system function and sympathetic tone. The metabolism of angiotensins and vasopressin depends on the action of certain aminopeptidases whose activity may be influenced by the autonomic nervous system. Their regulation may differ between WKY and SHR in hypothalamus and plasma according to the sympathetic tone. We analyzed aminopeptidases responsible for the hydrolysis of certain angiotensins, vasopressin, cholecystokinin or enkephalins in hypothalamus and plasma of WKY and SHR in untreated controls rats and under beta-adrenoceptor blockade...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29154809/facilitated-acquisition-of-the-classically-conditioned-eyeblink-response-in-active-duty-military-expressing-posttraumatic-stress-disorder-symptoms
#4
Justin D Handy, Pelin Avcu, Nora Ko, Alejandro Ortiz, Michael J Doria, Richard J Servatius
OBJECTIVE: Learning diathesis models underscore the role of hyper-conditioning in the development of PTSD following trauma exposure. Eyeblink classical conditioning is one method of examining associative learning biases independent of fear and threat produced by trauma. Facilitated learning is apparent in individuals self-expressing PTSD symptoms, as well as behaviorally inhibited (BI) temperament, a vulnerability factor for PTSD. Here, we examine eyeblink conditioning in active duty military personnel and relate learning with PTSD symptomology...
November 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29154734/effect-of-physical-activity-on-cardiac-autonomic-function-of-dairy-cows-on-commercial-dairy-farms
#5
Fruzsina Luca Kézér, János Tőzsér, Mikolt Bakony, Ottó Szenci, Viktor Jurkovich, Levente Kovács
Interbeat interval data were collected from 219 Holstein cows in 2 smaller-scale farms and 3 larger-scale farms to investigate the effects of posture (standing vs. lying), rumination (rumination vs. no rumination) and feeding on baseline values of heart rate (HR) and heart rate variability (HRV) parameters reflecting vagal and sympathetic activity. A General Linear Model was used for detecting factors (parity, milking technology, herd size) having possible effects on HRV calculated for undisturbed lying posture...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29154635/you-have-to-hear-this-using-tone-of-voice-to-motivate-others
#6
Netta Weinstein, Konstantina Zougkou, Silke Paulmann
The present studies explored the role of prosody in motivating others, and applied self-determination theory (Ryan & Deci, 2000) to do so. Initial studies describe patterns of prosody that discriminate motivational speech. Autonomy support was expressed with lower intensity, slower speech rate and less voice energy in both motivationally laden and neutral (but motivationally primed) sentences. In a follow-up study, participants were able to recognize motivational prosody in semantically neutral sentences, suggesting prosody alone may carry motivational content...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154634/the-contribution-of-perceptual-factors-and-training-on-varying-audiovisual-integration-capacity
#7
Jonathan M P Wilbiks, Benjamin J Dyson
The suggestion that the capacity of audiovisual integration has an upper limit of 1 was challenged in 4 experiments using perceptual factors and training to enhance the binding of auditory and visual information. Participants were required to note a number of specific visual dot locations that changed in polarity when a critical auditory stimulus was presented, under relatively fast (200-ms stimulus onset asynchrony [SOA]) and slow (700-ms SOA) rates of presentation. In Experiment 1, transient cross-modal congruency between the brightness of polarity change and pitch of the auditory tone was manipulated...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154632/auditory-over-visual-advantage-of-sensorimotor-synchronization-in-6-to-7-year-old-children-but-not-in-12-to-15-year-old-children-and-adults
#8
Yan Mu, Yingyu Huang, Chao Ji, Li Gu, Xiang Wu
The superiority of the auditory over visual modality in sensorimotor synchronization-a fundamental ability to coordinate movements with external rhythms-has long been established, whereas recent metronome synchronization work showed that synchronization of a visual bouncing ball was not less stable than synchronization of auditory tones in adults. The present study examined synchronization to isochronous sequences composed of auditory tones, visual flashes, or a bouncing ball in 6- to 7-year-old children, 12- to 15-year-old children, and 19- to 29-year-old adults...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154281/gradual-cerebral-hypoperfusion-impairs-fear-conditioning-and-object-recognition-learning-and-memory-in-mice-potential-roles-of-neurodegeneration-and-cholinergic-dysfunction
#9
Jogender Mehla, Sean Lacoursiere, Emily Stuart, Robert J McDonald, Majid H Mohajerani
In the present study, male C57BL/6J mice were subjected to gradual cerebral hypoperfusion by implanting an ameroid constrictor (AC) on the left common carotid artery (CCA) and a stenosis on the right CCA. In the sham group, all surgical procedures were kept the same except no AC was implanted and stenosis was not performed. One month following the surgical procedures, fear conditioning and object recognition tests were conducted to evaluate learning and memory functions and motor functions were assessed using a balance beam test...
November 14, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29154248/the-late-results-of-4000-hz-frequency-bone-conduction-after-tympanoplasty
#10
Joanna Janiak-Kiszka, Wojciech Kaźmierczak
INTRODUCTION: Surgical treatment of conductive hearing loss runs the risk of damage to the inner ear in the mechanism of acoustic trauma. AIM: The aim of this study was to evaluate the function of the organ of Corti, expressed as bone conduction threshold at the frequency of 4000 Hz for selected operations: mastoidectomy and canal-wall-down procedure. MATERIAL AND METHODS: The material was collected from patients with chronic otitis media in the Department of Otolaryngology and ENT Oncology, Collegium Medicum of Nicolaus Copernicus University in Bydgoszcz in 2004-2009...
October 30, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29154174/immunoresolvents-signaling-molecules-at-intersection-between-the-brain-and-immune-system
#11
REVIEW
Jesmond Dalli, Charles N Serhan
Understanding mechanisms that control immunity is central in the quest to gain insights into the etiopathology of many of the diseases that afflict modern societies. New results implicate the nervous system as a central player in controlling many aspects of both the innate and adaptive arms of the immune response. Furthermore it is now well appreciated that a novel group of autacoids termed as specialized proresolving mediators, which are enzymatically produced from essential fatty acids, orchestrate the immune response promoting the termination of inflammation as well as tissue repair and regeneration...
November 16, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29153918/nursing-music-protocol-and-postoperative-pain
#12
REVIEW
Michael J Poulsen, Jeffrey Coto
Pain has always been a major concern for patients and nurses during the postoperative period. Therapies, medicines, and protocols have been developed to improve pain and anxiety but have undesirable risks to the patient. Complementary and alternative medicine therapies have been studied but have not been applied as regular protocols in the hospital setting. Music is one type of complementary and alternative medicine therapy that has been reported to have favorable results on reducing postoperative pain, anxiety, and opioid usage...
November 16, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29153260/diagnostic-criteria-for-patulous-eustachian-tube-a-proposal-by-the-japan-otological-society
#13
Toshimitsu Kobayashi, Masahiro Morita, Satoshi Yoshioka, Kunihiro Mizuta, Shigeto Ohta, Toshiaki Kikuchi, Tatsuya Hayashi, Akihiro Kaneko, Nobumasa Yamaguchi, Sho Hashimoto, Hiromi Kojima, Shingo Murakami, Haruo Takahashi
Patulous Eustachian Tube (PET) is of increasing importance in otology. However, despite the abundance of diseases requiring a differential diagnosis from PET, such as superior semicircular canal dehiscence syndrome, perilymphatic fistula, acute low-tone sensorineural hearing loss, etc., there are currently no established diagnostic criteria for PET. In view of these circumstances, the Japan Otological Society (JOS) Eustachian Tube Committee proposed the diagnostic criteria for Patulous Eustachian Tube in 2012, in order to promote clinical research on PET...
November 15, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29153256/intraoperative-force-and-electrocochleography-measurements-in-an-animal-model-of-cochlear-implantation
#14
J Lo, C Bester, A Collins, C Newbold, A Hampson, S Chambers, H Eastwood, S O'Leary
To preserve residual hearing, techniques for monitoring and reducing the effects of trauma during cochlear implant surgery are being developed. This study examines the relationships between intraoperative recordings (electrode insertion force and electrocochleography), trauma, and hearing loss after cochlear implantation. The study also evaluated the efficacy of intravenous steroids for reducing hearing loss after implantation. Thirty-two normal-hearing guinea pigs were randomly implanted with electrode arrays of differing stiffness ('hard' or 'soft')...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29152945/dna-methylation-of-the-prestin-gene-and-outer-hair-cell-electromotileresponse-of-the-cochlea-in-salicylate-administration
#15
(no author information available yet)
Background/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs.Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29152859/deletion-of-the-egf-receptor-in-vascular-smooth-muscle-cells-prevents-chronic-angiotensin-ii-induced-arterial-wall-stiffening-and-media-thickening
#16
Barbara Schreier, Mirja Hünerberg, Sigrid Mildenberger, Sindy Rabe, Daniel Bethmann, Claudia Wickenhauser, Michael Gekle
AIM: In vivo vascular smooth muscle cell (VSMC) EGF receptor (EGFR) contributes to acute angiotensin II (AII) effects on vascular tone and blood pressure. The ubiquitously expressed EGFR has been implicated in vascular remodeling preceding end-organ damage by pharmacological inhibition, and AII signaling in cultured vascular cells is partly EGFR dependent. However the role of VSMC-EGFR in vivo during AII-induced pathophysiological processes is not known. METHODS: The present study assesses the in vivo relevance of VSMC-EGFR during chronic AII challenge without further stressors, using a mouse model with inducible, VSMC-specific EGFR knock out (VSMC-EGFR-KO)...
November 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29152685/cerebral-palsy-an-overview
#17
REVIEW
Sheffali Gulati, Vishal Sondhi
Cerebral palsy (CP) is a neurodevelopmental disorder characterized by abnormalities of muscle tone, movement and motor skills, and is attributed to injury to the developing brain. The clinical features of this entity evolve over time and the specific CP syndrome may be recognizable only after 3-5 y of age; although suggestive signs and symptoms may be present at an earlier age. The management involves neurological rehabilitation (addressing muscle tonal abnormalities, and devising physical and occupational therapies) and diagnosis and management of co-morbidities (including epilepsy, impairment of cognition, vision, hearing, and disturbances of growth and gastrointestinal function)...
November 20, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29152236/low-levels-of-very-long-chain-n-3-pufa-in-atlantic-salmon-salmo-salar-diet-reduce-fish-robustness-under-challenging-conditions-in-sea-cages
#18
Marta Bou, Gerd M Berge, Grete Baeverfjord, Trygve Sigholt, Tone-Kari Østbye, Bente Ruyter
The present study aimed to determine the minimum requirements of the essential n-3 fatty acids EPA and DHA in Atlantic salmon (Salmo salar) that can secure their health under challenging conditions in sea cages. Individually tagged Atlantic salmon were fed 2, 10 and 17 g/kg of EPA + DHA from 400 g until slaughter size (about 3·5 kg). The experimental fish reared in sea cages were subjected to the challenging conditions typically experienced under commercial production. Salmon receiving the lowest EPA + DHA levels showed lower growth rates in the earlier life stages, but no significant difference in final weights at slaughter...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29151577/orexin-modulates-behavioral-fear-expression-through-the-locus-coeruleus
#19
Shingo Soya, Tohru M Takahashi, Thomas J McHugh, Takashi Maejima, Stefan Herlitze, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
Emotionally salient information activates orexin neurons in the lateral hypothalamus, leading to increase in sympathetic outflow and vigilance level. How this circuit alters animals' behavior remains unknown. Here we report that noradrenergic neurons in the locus coeruleus (NA(LC) neurons) projecting to the lateral amygdala (LA) receive synaptic input from orexin neurons. Pharmacogenetic/optogenetic silencing of this circuit as well as acute blockade of the orexin receptor-1 (OX1R) decreases conditioned fear responses...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29151071/an-observational-cohort-study-of-3-units-versus-5-units-slow-intravenous-bolus-oxytocin-in-women-undergoing-elective-caesarean-delivery
#20
N Terblanche, P Otahal, A Messmer, P Wright, S Patel, K Nathan, J E Sharman
This study sought to compare postpartum blood loss and maternal outcomes after 3IU and 5IU oxytocin at elective caesarean delivery. In a prospective observational study, 73 women undergoing elective caesarean delivery under spinal anaesthetic received a slow I.V. injection of either 3IU (n = 35) or 5IU (n = 38) oxytocin after delivery. The main outcome was gravimetrically measured 24-hour postpartum blood loss with a non-inferiority margin of 300 mL. Uterine tone, phenylephrine dose, emesis and hypotension after oxytocin administration were secondary outcomes...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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