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https://www.readbyqxmd.com/read/29657893/targeting-accuracy-at-couch-kick-for-a-frameless-image-guided-radiosurgery-system
#1
Yimei Huang, Bo Zhao, Joshua Kim, Ning Wen, Indrin J Chetty, Salim Siddiqui
Purpose/Objectives: Targeting accuracy at all possible couch angles needs to be carefully evaluated prior to initiating a frameless image-guided stereotactic radiosurgery program on a Linac for treating functional disorders such as trigeminal neuralgia. In this study, we report positioning accuracy with stereoscopic x-ray imaging over the complete range of couch rotation using anthropomorphic head phantoms. Materials/Methods: An anthropomorphic head phantom with three 5 mm tungsten BBs as hidden targets was CT simulated...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29650086/influenza-pneumococcal-hepatitis-b-and-herpes-zoster-vaccinations
#2
Nadira Husein, Ashen Chetty
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29629676/a-proposed-management-algorithm-for-late-onset-efavirenz-neurotoxicity
#3
H M Cross, S Chetty, M T Asukile, H S Hussey, E B Lee Pan, L M Tucker
A high proportion of HIV-positive patients in South Africa receive concomitant efavirenz (EFV) and isoniazid (INH) therapy. EFV is metabolised in the liver via CYP2B6, and genetic polymorphism of CYP2B6 is known to result in slowed metabolism of the drug. INH is also metabolised in the liver, causing inhibition of a pathway that plays an important role in slow EFV metabolisers. Concomitant INH use therefore affects plasma levels of EFV. EFV is well known to cause neuropsychiatric side-effects on initiation, and a recent adult case series described late-onset neurotoxicity in the form of subacute ataxia and encephalopathy in patients treated with EFV for a median of 2 years, in association with toxic plasma levels of the drug...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29555972/tio-2-nanoparticles-induce-omphalocele-in-chicken-embryo-by-disrupting-wnt-signaling-pathway
#4
Shweta Patel, Sarmita Jana, Rajlakshmi Chetty, Sonal Thakore, Man Singh, Ranjitsinh Devkar
Titanium dioxide nanoparticles (TiO2 NPs) are among abundantly used metal oxide NPs but their interactions with biomolecules and subsequent embryonic toxicity in higher vertebrates is not extensively reported. Physicochemical interactions of TiO2 NPs with egg albumen reveals that lower doses of TiO2 NPs (10 and 25 µg/ml) accounted for higher friccohesity and activation energy but an increment in molecular radii was recorded at higher doses (50 and 100 µg/ml). FTIR analysis revealed conformational changes in secondary structure of egg albumen as a result of electrostratic interactions between egg albumen and TiO2 NPs...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29512239/the-changing-vista-of-pleural-effusion-management-indwelling-pleural-catheters-ipc
#5
Sarah Jane Messeder, Mahendran Chetty, Megan C Thomson, Graeme P Currie
No abstract text is available yet for this article.
March 7, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29510557/updates-in-the-development-of-immunornases-for-the-selective-killing-of-tumor-cells
#6
REVIEW
Sandra Jordaan, Olusiji A Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic protein composing an immunotoxin (IT). Non-human cytotoxic proteins, while potent, have limited clinical efficacy due to their immunogenicity and potential off-target toxicity. Humanization of the cytotoxic payload is essential and requires harnessing of potent apoptosis-inducing human proteins with conditional activity, which rely on targeted delivery to contact their substrate...
March 5, 2018: Biomedicines
https://www.readbyqxmd.com/read/29508370/aflibercept-in-diabetic-macular-oedema-previously-refractory-to-standard-intravitreal-therapy-an-irish-retrospective-study
#7
Clare F McCloskey, Ann-Marie Mongan, Shivona Chetty, Darren M J McAteer, Shauna M Quinn
INTRODUCTION: To determine visual and anatomical outcomes of diabetic macular oedema (DMO) patients in a tertiary centre following conversion to aflibercept having been refractory to previous treatment with bevacizumab/ranibizumab. METHODS: A retrospective case series of patients with a diagnosis of DMO undergoing aflibercept intravitreal therapy for at least 6 months who had previous treatment with three consecutive bevacizumab/ranibizumab injections pre-switch...
March 5, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29480158/utilization-of-a-hybrid-finite-element-based-registration-method-to-quantify-heterogeneous-tumor-response-for-adaptive-treatment-for-lung-cancer-patients
#8
Hoda Sharifi, Hong Zhang, Hassan Bagher Ebadian, Wei Lu, Munther I Ajlouni, Jian-Yue Jin, Feng-Ming Spring Kong, Indrin J Chetty, Hualiang Zhong
Tumor response to radiation treatment (RT) can be evaluated from changes in metabolic activity between two positron emission tomography (PET) images. Activity changes at individual voxels in pre-treatment PET images (PET1), however, cannot be derived until their associated PET-CT (CT1) images are appropriately registered to during-treatment PET-CT (CT2) images. This study aimed to investigate the feasibility of using deformable image registration (DIR) techniques to quantify radiation-induced metabolic changes on PET images...
February 26, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29470508/preterm-delivery-and-small-for-gestation-outcomes-in-hiv-infected-pregnant-women-on-antiretroviral-therapy-in-rural-south-africa-results-from-a-cohort-study-2010-2015
#9
Terusha Chetty, Claire Thorne, Anna Coutsoudis
OBJECTIVES: Increasingly more women conceive on antiretroviral therapy (ART) with non-nucleoside reverse transcriptase-based regimens. This study assessed the effect of preconception tenofovir disoproxil fumarate (TDF)-lamivudine (3TC)/emtricitabine (FTC)-efavirenz (EFV) and post-conception TDF-(3TC/FTC)-EFV (versus other regimens) on preterm delivery (PTD) and small-for-gestational age (SGA) births. METHODS: We analysed data of 2549 HIV-infected women attending antenatal clinics in KwaZulu-Natal from 2010 through 2015 in this retrospective cohort study...
2018: PloS One
https://www.readbyqxmd.com/read/29431865/refinement-of-mlc-modelling-improves-comercial-qa-dosimetry-system-for-srs-and-sbrt-patient-specific-qa
#10
Yair Hillman, Josh Kim, Indrin Chetty, Ning Wen
PURPOSE: Mobius 3D (M3D) provides a volumetric dose verification of the treatment planning system's calculated dose using an independent beam model and a collapsed cone convolution superposition algorithm. However, there is a lack of investigation into M3D's accuracy and effectiveness for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) quality assurance (QA). Here, we collaborated with the vendor to develop a revised M3D beam model for SRS/SBRT cases treated with a 6X Flattening Filter Free (FFF) beam and high definition multiple leaf collimator (HDMLC) on an Edge linear accelerator...
February 12, 2018: Medical Physics
https://www.readbyqxmd.com/read/29419412/neural-and-neurogenic-tumours-of-the-gastroenteropancreaticobiliary-tract
#11
REVIEW
Aoife J McCarthy, Dipti M Karamchandani, Runjan Chetty
Neural lesions occur uncommonly in the gastroenteropancreaticobiliary tract. However, due to the growing number of screening colonoscopy procedures, polypoid neural lesions of the colon are being recognised increasingly and range from benign tumours to high-grade malignant neoplasms. Morphological variability of neural tumours can be wide, although some entities share pathological features, and, as such, these lesions can be diagnostically challenging. We review the spectrum of pathology of neural tumours in the gastroenteropancreaticobiliary tract, with the goal of providing a practical approach for practising surgical pathologists...
February 1, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29371175/integrated-decentralized-training-for-health-professions-education-at-the-university-of-kwazulu-natal-south-africa-protocol-for-the-i-dect-project
#12
Pragashnie Govender, Verusia Chetty, Deshini Naidoo, Ntsikelelo Pefile
BACKGROUND: The Integrated Decentralized Training (i-DecT) project was created to address the current need for health care in South Africa among resource poor climates in rural and periurban settings. The University of KwaZulu-Natal (UKZN) in South Africa has embarked on a program within the School of Health Sciences (SHS) to decentralize the clinical learning platform in order to address this disparity. Framed in a pragmatic stance, this proposal is geared towards informing the roll out of decentralized clinical training (DCT) within the province of KwaZulu-Natal...
January 25, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29358476/tumours-composed-of-fat-are-no-longer-a-simple-diagnosis-an-overview-of-fatty-tumours-with-a-spindle-cell-component
#13
REVIEW
Aoife J McCarthy, Runjan Chetty
This is a review of the morphological spectrum of fatty tumours containing a component of spindle cells, highlighting the immunohistochemical and cytogenetic workup that is now mandatory for accurate diagnosis, with the goal of providing a practical approach for practising surgical pathologists. There have been significant advances in recent years in classifying and understanding the pathogenesis of fatty tumours with spindle cells, based on the correlation of histological, immunohistochemical and cytogenetic/molecular findings...
January 22, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29349606/well-differentiated-liposarcoma-atypical-lipomatous-tumor-presenting-as-an-esophageal-polyp
#14
Aoife J McCarthy, Paul Carroll, Rajkumar Vajpeyi, Gail Darling, Runjan Chetty
No abstract text is available yet for this article.
January 19, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29316828/hodgkin-s-lymphoma-and-its-association-with-ebv-and-hiv-infection
#15
Ravnit Grewal, Alexandra Irimie, Nasheen Naidoo, Nooroudien Mohamed, Bobe Petrushev, Manogari Chetty, Ciprian Tomuleasa, Emmanuel-Akinola Abayomi
Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Usually, patients present with late stage disease often involving the bone marrow at the time of diagnosis...
March 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29281933/toxicity-evaluation-of-magnetic-iron-oxide-nanoparticles-reveals-neuronal-loss-in-chicken-embryo
#16
Shweta Patel, Sarmita Jana, Rajlakshmi Chetty, Sonal Thakore, Man Singh, Ranjitsinh Devkar
Magnetic iron oxide nanoparticles (IONs) display the ability to cross blood - brain barrier and are envisioned as diagnostic and therapeutic applications, but there are few studies on their potential embryonic toxicity in higher vertebrates. This study investigates interaction of IONs with egg albumen and its subsequent toxicity on chicken embryo. Physicochemical interactions of IONs with egg albumen revealed alterations in friccohesity and secondary structural changes due to weak Vander Waals forces. Toxicity assessment of IONs (10, 25, 50, 100, and 200 µg/ml doses) on chicken embryo accounted for 100% mortality at 200 µg/ml dose due to Fe2+ ions overload...
December 27, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29280464/adaptive-radiation-therapy-off-line-on-line-and-in-line
#17
EDITORIAL
Indrin J Chetty, Jonas Fontenot
No abstract text is available yet for this article.
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29258292/corrigendum-phylogenetic-ctdna-analysis-depicts-early-stage-lung-cancer-evolution
#18
Christopher Abbosh, Nicolai J Birkbak, Gareth A Wilson, Mariam Jamal-Hanjani, Tudor Constantin, Raheleh Salari, John Le Quesne, David A Moore, Selvaraju Veeriah, Rachel Rosenthal, Teresa Marafioti, Eser Kirkizlar, Thomas B K Watkins, Nicholas McGranahan, Sophia Ward, Luke Martinson, Joan Riley, Francesco Fraioli, Maise Al Bakir, Eva Grönroos, Francisco Zambrana, Raymondo Endozo, Wenya Linda Bi, Fiona M Fennessy, Nicole Sponer, Diana Johnson, Joanne Laycock, Seema Shafi, Justyna Czyzewska-Khan, Andrew Rowan, Tim Chambers, Nik Matthews, Samra Turajlic, Crispin Hiley, Siow Ming Lee, Martin D Forster, Tanya Ahmad, Mary Falzon, Elaine Borg, David Lawrence, Martin Hayward, Shyam Kolvekar, Nikolaos Panagiotopoulos, Sam M Janes, Ricky Thakrar, Asia Ahmed, Fiona Blackhall, Yvonne Summers, Dina Hafez, Ashwini Naik, Apratim Ganguly, Stephanie Kareht, Rajesh Shah, Leena Joseph, Anne Marie Quinn, Phil A Crosbie, Babu Naidu, Gary Middleton, Gerald Langman, Simon Trotter, Marianne Nicolson, Hardy Remmen, Keith Kerr, Mahendran Chetty, Lesley Gomersall, Dean A Fennell, Apostolos Nakas, Sridhar Rathinam, Girija Anand, Sajid Khan, Peter Russell, Veni Ezhil, Babikir Ismail, Melanie Irvin-Sellers, Vineet Prakash, Jason F Lester, Malgorzata Kornaszewska, Richard Attanoos, Haydn Adams, Helen Davies, Dahmane Oukrif, Ayse U Akarca, John A Hartley, Helen L Lowe, Sara Lock, Natasha Iles, Harriet Bell, Yenting Ngai, Greg Elgar, Zoltan Szallasi, Roland F Schwarz, Javier Herrero, Aengus Stewart, Sergio A Quezada, Karl S Peggs, Peter Van Loo, Caroline Dive, C Jimmy Lin, Matthew Rabinowitz, Hugo J W L Aerts, Allan Hackshaw, Jacqui A Shaw, Bernhard G Zimmermann, Charles Swanton
This corrects the article DOI: 10.1038/nature22364.
February 8, 2018: Nature
https://www.readbyqxmd.com/read/29249335/an-automated-dose-tracking-system-for-adaptive-radiation-therapy
#19
Chang Liu, Jinkoo Kim, Akila Kumarasiri, Essa Mayyas, Stephen L Brown, Ning Wen, Farzan Siddiqui, Indrin J Chetty
BACKGROUND AND OBJECTIVE: The implementation of adaptive radiation therapy (ART) into routine clinical practice is technically challenging and requires significant resources to perform and validate each process step. The objective of this report is to identify the key components of ART, to illustrate how a specific automated procedure improves efficiency, and to facilitate the routine clinical application of ART. METHODS: Data was used from patient images, exported from a clinical database and converted to an intermediate format for point-wise dose tracking and accumulation...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29158450/70-years-of-the-jcp-highly-cited-papers-the-causal-relation-between-human-papillomavirus-and-cervical-cancer
#20
EDITORIAL
Runjan Chetty
No abstract text is available yet for this article.
December 2017: Journal of Clinical Pathology
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