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Polycystic ovary syndrome

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https://www.readbyqxmd.com/read/29766146/the-effect-of-resveratrol-on-oxidative-stress-in-the-liver-and-serum-of-a-rat-model-of-polycystic-ovary-syndrome-an-experimental-study
#1
Mahnaz Ghowsi, Homayoun Khazali, Sajjad Sisakhtnezhad
Background: Studies of oxidative status in polycystic ovarian syndrome (PCOS) patients are limited with inconsistent results. The effects of resveratrol as a natural antioxidant on oxidative status in PCOS aren't clear. Objective: This study evaluated effects of resveratrol on oxidative stress in the liver and serum of the PCOS rats. Materials and Methods: Fifteen female Wistar rats (3 wk old) were divided into 3 groups (n=5/each e): Control group, PCO-Control group, and PCO-Resveratrol group...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29765334/high-frequency-electrical-modulation-of-the-superior-ovarian-nerve-as-a-treatment-of-polycystic-ovary-syndrome-in-the-rat
#2
Victor Pikov, Arun Sridhar, Hernan E Lara
The polycystic ovary syndrome (PCOS) is the most prevalent ovarian pathology in women, with excessive sympathetic activity in the superior ovarian nerve (SON) playing an important role in inducing the PCOS symptoms in the rats and humans. Our previous studies have shown that surgical transection of the SON can reverse the disease progression, prompting us to explore the effect of the kilohertz frequency alternating current (KHFAC) modulation as a method of reversible non-surgical suppression of the nerve activity in the rodent model of PCOS...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29763897/does-the-pituitary-gland-volume-change-in-polycystic-ovary-syndrome
#3
Sezen Bozkurt Koseoglu, Funda Dinc Elibol
AIMS: Polycystic ovary syndrome (PCOS) is the commonest cause of menstrual irregularity and hirsutism during reproductive age. We hypothesized in the alterations in the pituitary gland in PCOS. METHODS: We measured the volume of the pituitary gland in 39 PCOS patients and 42 age-matched healthy controls using 0.35 mm thick T1-weighted sagittal cranial images. Serum levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured on days 3-5 of the menstrual cycle of the participants...
May 15, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29762821/the-influencing-mechanism-of-mtor-signal-pathway-mediated-by-mitofusin-2-in-development-of-follicle
#4
Q-Y Luo, P Huo, L-L Wang, X-H Wu
OBJECTIVE: To investigate the influencing mechanism of mammalian target of rapamycin (mTOR) signal pathway mediated by mitofusin-2 (Mfn2) in the development of follicle. MATERIALS AND METHODS: We selected 20 healthy Sprague Dawley (SD) female rats aging between 6 and 8 weeks were divided into the control group and the polycystic ovarian syndrome (PCOS) model group. Rats in PCOS group received the lavage using 0.4 mL 1% carboxymethyl cellulose solution containing letrozole (1 mg/kg/d) consecutively for 20 to 25d...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760445/elevated-prenatal-anti-m%C3%A3-llerian-hormone-reprograms-the-fetus-and-induces-polycystic-ovary-syndrome-in-adulthood
#5
Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A Malone, Anne Loyens, Pascal Pigny, Didier Dewailly, Sophie Catteau-Jonard, Inger Sundström-Poromaa, Terhi T Piltonen, Federica Dal Bello, Claudio Medana, Vincent Prevot, Jerome Clasadonte, Paolo Giacobini
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and corresponds with a high degree of comorbidities and economic burden. How PCOS is passed on from one generation to the next is not clear, but it may be a developmental condition. Most women with PCOS exhibit higher levels of circulating luteinizing hormone, suggestive of heightened gonadotropin-releasing hormone (GnRH) release, and anti-Müllerian hormone (AMH) as compared to healthy women. Excess AMH in utero may affect the development of the female fetus...
May 14, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29760297/follicular-hyperandrogenism-and-insulin-resistance-in-polycystic-ovary-syndrome-patients-with-normal-circulating-testosterone-levels
#6
Andi Li, Lu Zhang, Jiajia Jiang, Nan Yang, Ying Liu, Lingbo Cai, Yugui Cui, Feiyang Diao, Xiao Han, Jiayin Liu, Yujie Sun
Polycystic ovary syndrome (PCOS) is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandrogenemia. The microenvironment of the ovary critically influences follicular development. In the present study, we assessed the role of androgen in PCOS by investigating whether excessive follicular fluid androgen was present in PCOS patients with normal serum androgen levels and influenced by follicular fluid insulin resistance (IR)...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29757997/tetragonia-tetragonioides-pall-kuntze-regulates-androgen-production-in-a-letrozole-induced-polycystic-ovary-syndrome-model
#7
Bo-Jeong Pyun, Hyun Yang, Eunjin Sohn, Song Yi Yu, Dongoh Lee, Dong Ho Jung, Byoung Seob Ko, Hye Won Lee
Tetragonia tetragonioides (Pall.) Kuntze (TTK) is a medicinal plant traditionally used to treat various diseases such as diabetic, inflammatory, and female-related disorders. Polycystic ovary syndrome (PCOS) is a common endocrinological disorder in women of reproductive age, and hyperandrogenism is a prominent feature of PCOS resulting in anovulation and infertility. In this study, we investigated the effects of a TTK extract on androgen generation and regulation of steroidogenic enzymes in vitro and in vivo...
May 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29757582/effects-of-orlistat-on-serum-androgen-levels-among-iranian-obese-women-with-polycystic-ovarian-syndrome
#8
Saghar Salehpour, Sedighe Hosseini, Leila Nazari, Nasrin Saharkhiz, Shahrzad Zademodarres
INTRODUCTION: Polycystic ovary syndrome is one of the most common endocrinopathies in young women, and it affects 6% to 8% of women in reproductive age. Hyperandrogenism is the hallmark of polycystic ovary syndrome. The aim of the present study was to evaluate the effects of orlistat on weight loss and serum androgen levels among Iranian women with polycystic ovary syndrome. METHODS: The present study was carried out in the clinic of Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran...
May 14, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29755223/study-to-evaluate-the-changes-in-polycystic-ovarian-morphology-after-naturopathic-and-yogic-interventions
#9
M Ezhil Ratnakumari, N Manavalan, D Sathyanath, Y Rosy Ayda, K Reka
Background: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders in women, with a prevalence ranging from 2.2% to 26% in India. Patients with PCOS face challenges including irregular menstrual cycles, hirsutism, acne, acanthosis nigricans, obesity and infertility. 9.13% of South Indian adolescent girls are estimated to suffer from PCOS. The efficacy of Yoga & Naturopathy (Y&N) in the management of polycystic ovarian syndrome requires to be investigated...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29752839/the-role-of-mtor-in-ovarian-cancer-polycystic-ovary-syndrome-and-ovarian-aging
#10
REVIEW
Jin Liu, Dai-Chao Wu, Li-Hua Qu, Hong-Qing Liao, Mei-Xiang Li
The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions...
May 12, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29752614/data-do-not-support-effectiveness-of-acupuncture-for-improving-live-birth-rate-in-women-with-polycystic-ovary-syndrome
#11
Hong-Ying Kuang, Yan Li, He-Ping Zhang, Richard S Legro, Elisabet Stener-Victorin
No abstract text is available yet for this article.
May 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29749830/lepr-gene-polymorphism-and-plasma-soluble-leptin-receptor-levels-are-associated-with-polycystic-ovary-syndrome-in-han-chinese-women
#12
Xiaoyu Tu, Chuanning Yu, Minzhi Gao, Yu Zhang, Zhaofeng Zhang, Yaqiong He, Lihua Yao, Jing Du, Yun Sun, Zhaogui Sun
AIM: To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women. PATIENTS & METHODS: LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured. RESULTS: The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups...
July 2017: Personalized Medicine
https://www.readbyqxmd.com/read/29749110/metformin-for-the-prevention-of-hypertensive-disorders-of-pregnancy-in-women-with-gestational-diabetes-and-obesity-a-systematic-review-and-meta-analysis
#13
REVIEW
Erkan Kalafat, Yavuz Emre Sukur, Abdulkadir, Basky Thilaganathan, Asma Khalil
OBJECTIVES: Metformin has been reported to reduce the risk of preeclampsia. It is also known to influence soluble fms-like tyrosine kinase-1 (sFlt-1) levels, which correlate significantly with the gestation of onset and severity of preeclampsia. The main aim of this systematic review and meta-analysis was to determine whether metformin use is associated with the incidence of hypertensive disorders of pregnancy (HDP). METHODS: MEDLINE (1947 - September 2017), Scopus (1970 - September 2017) and the Cochrane Library (since inception - September 2017) were searched for relevant citations in English language...
May 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29747700/effects-of-myo-inositol-plus-alpha-lactalbumin-in-myo-inositol-resistant-pcos-women
#14
Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno, Vittorio Unfer
BACKGROUND: Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS: PCOS patients, according to the Rotterdam ESHRE-ASRM criteria, with anovulation and infertility > 1 year, were included in this open and prospective study. The preliminary phase was aimed at determining a set of MI-resistant PCOS patients...
May 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29747678/a-potential-link-between-polycystic-ovary-syndrome-and-non-alcoholic-fatty-liver-disease-an-update-meta-analysis
#15
Jia Wu, Xin-Yu Yao, Ru-Xia Shi, Su-Fen Liu, Xiao-Yong Wang
BACKGROUND: Epidemiological literature regarding the effect of polycystic ovary syndrome (PCOS) as a risk factor for non-alcoholic fatty liver disease (NAFLD) remains inconsistent. Furthermore, it remains debatable whether NAFLD is associated with PCOS as a consequence of shared risk factors or whether PCOS contributes to NAFLD in an independent fashion. Therefore, this meta-analysis was conducted. METHODS: This meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
May 10, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29747212/association-between-insulin-resistance-and-cardiovascular-risk-factors-in-polycystic-ovary-syndrome-patients
#16
Miriam da Silva Wanderley, Lara Cristina Ribeiro Pereira, Carla Borges Santos, Vinícius Santos da Cunha, Mariam Viviane Jovino Neves
OBJECTIVE:  To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. METHODS:  Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29745981/evaluation-of-biochemical-endocrine-and-metabolic-biomarkers-for-the-early-diagnosis-of-polycystic-ovary-syndrome-among-non-obese-saudi-women
#17
Maha H Daghestani
OBJECTIVE: To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome (PCOS) among non-obese women. METHODS: A prospective observational cross-sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non-obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non-obese normo-ovulatory women without signs of PCOS (control group; n=44)...
May 10, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29741763/endometrial-neoplasia-in-reproductive-aged-thai-women-with-polycystic-ovary-syndrome
#18
Suchada Indhavivadhana, Manee Rattanachaiyanont, Thanyarat Wongwananuruk, Kitirat Techatraisak, Nana Rayasawath, Chongdee Dangrat
OBJECTIVE: To determine the risk of endometrial neoplasia in relation to endometrial thickness and to evaluate factors influencing endometrial thickness in reproductive-aged Thai women with polycystic ovary syndrome (PCOS). METHODS: The present cross-sectional study was done at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, between October 1, 2010, and January 31, 2013. We recruited women (aged ≥18 years) with PCOS diagnosed according to the revised 2003 Rotterdam criteria...
May 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29739821/c-type-natriuretic-peptide-a-link-between-hyperandrogenism-and-anovulation-in-a-mouse-model-of-polycystic-ovary-syndrome
#19
Adelina M Reis, Kinulpe Honorato-Sampaio
The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. Despite the great amount of research in the area, mechanisms involved in the genesis of this syndrome remain poorly understood. In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen...
May 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29739096/measurement-differences-between-two-immunoassay-systems-for-lh-and-fsh-a-comparison-of-roche-cobas-e601-vs-abbott-architect-i2000sr
#20
Lianli Yin, Yinghua Tang, Xiang Chen, Yifan Sun
BACKGROUND: Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate the growth and reproductive activity of gonadal tissue and determine the concentration of LH is essential for the prediction of ovulation. Collectively, FSH and LH are important measurements to ascertain the causes of infertility as well as diagnosing disorders such as polycystic ovary syndrome and pituitary and gonadal dysfunction. This study compares the correlation between LH and FSH measurements during examination with two different systems, Architect i2000sr (Abbott Laboratories; Lake Bluff, IL, USA) and Cobas e601 (Roche; Geneva, Switzerland), and assesses the differences between these systems...
March 1, 2018: Clinical Laboratory
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