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https://www.readbyqxmd.com/read/28814958/does-survival-vary-for-breast-cancer-patients-in-the-united-states-a-study-from-six-randomly-selected-states
#1
Hafiz M R Khan, Lisaann S Gittner, Abhilash Perisetti, Anshul Saxena, Aamrin Rafiq, Kemesha Gabbidon, Sarah Mende, Maria Lyuksyutova
BACKGROUND: Breast cancer is the most common cancer in women. Disparities in some characteristics of breast cancer patients and their survival data for six randomly selected states in the US were examined. MATERIALS AND METHODS: A probability random sampling method was used to select the records of 2,000 patients from each of six randomly selected states. Demographic and disease characteristics were extracted from the Surveillance Epidemiology and End Results (SEER) database...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28811879/growth-and-fecundity-of-fertile-miscanthus%C3%A2-%C3%A3-%C3%A2-giganteus-powercane-compared-to-feral-and-ornamental-miscanthus-sinensis-in-a-common-garden-experiment-implications-for-invasion
#2
Maria N Miriti, Tahir Ibrahim, Destiny Palik, Catherine Bonin, Emily Heaton, Evans Mutegi, Allison A Snow
Perennial grasses are promising candidates for bioenergy crops, but species that can escape cultivation and establish self-sustaining naturalized populations (feral) may have the potential to become invasive. Fertile Miscanthus × giganteus, known as "PowerCane," is a new potential biofuel crop. Its parent species are ornamental, non-native Miscanthus species that establish feral populations and are sometimes invasive in the USA. As a first step toward assessing the potential for "PowerCane" to become invasive, we documented its growth and fecundity relative to one of its parent species (Miscanthus sinensis) in competition with native and invasive grasses in common garden experiments located in Columbus, Ohio and Ames, Iowa, within the targeted range of biofuel cultivation...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811267/app-a%C3%AE-structural-diversity-and-alzheimer-s-disease-pathogenesis
#3
REVIEW
Alex E Roher, Tyler A Kokjohn, Steven G Clarke, Michael R Sierks, Chera L Maarouf, Geidy E Serrano, Marwan S Sabbagh, Thomas G Beach
The amyloid cascade hypothesis of Alzheimer's disease (AD) proposes amyloid- β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1-40 and 1-42 peptides. However, alternative APP proteolytic processing produces a complex roster of Aβ species. In addition, Aβ peptides are subject to extensive posttranslational modification (PTM). We propose that amplified production of some APP/Aβ species, perhaps exacerbated by differential gene expression and reduced peptide degradation, creates a diverse spectrum of modified species which disrupt brain homeostasis and accelerate AD neurodegeneration...
August 12, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28805279/extreme-weather-year-sequences-have-non-additive-effects-on-environmental-nitrogen-losses
#4
Javed Iqbal, Magdalena Necpalova, Sotirios V Archontoulis, Robert P Anex, Marie Bourguignon, Daryl Herzmann, David C Mitchell, John E Sawyer, Qing Zhu, Michael J Castellano
The frequency and intensity of extreme weather years, characterized by abnormal precipitation and temperature, are increasing. In isolation, these years have disproportionately large effects on environmental N losses. However, the sequence of extreme weather years (e.g., wet-dry vs. dry-wet) may affect cumulative N losses. We calibrated and validated the DAYCENT ecosystem process model with a comprehensive set of biogeophysical measurements from a corn-soybean rotation managed at three N fertilizer inputs with and without a winter cover crop in Iowa, USA...
August 14, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28804746/black-women-s-recommendations-for-developing-effective-type-2-diabetes-programming
#5
Tera R Hurt, Asani H Seawell, Carolyn Cutrona, Margaret C O'Connor, Randie D Camp, Roxanne Duran, Reid Elderts, Chrishelda Green, Vanessa Hara, Jenna Pattee
The purpose of this study was to learn from 29 Black women how to develop effective Type 2 diabetes programming. Three focus groups were held in Des Moines, Iowa, during fall 2012. Results highlighted themes related to diabetes knowledge, diabetes management and prevention, physical activity, diet, and diabetes management programming. Opinions were shared as to whether family members should be included in programs for supporting those diagnosed with diabetes. These results provided guidance and ideas to scholars and health care professionals aiming to improve effectiveness of diabetes programs for Black women and families...
January 2017: Global Qualitative Nursing Research
https://www.readbyqxmd.com/read/28803724/implementation-and-outcomes-of-an-evidence-based-precepting-program-for-burn-nurses
#6
Johnnie R Robbins, Krystal K Valdez-Delgado, Nicole W Caldwell, Linda H Yoder, Elizabeth J Hayes, Michaèl G Barba, Hope L Greeley, Colleen Mitchell, Elizabeth A Mann-Salinas
INTRODUCTION: There is significant nationwide interest in transitioning new and new-to-specialty nurses into practice, especially in burn care. Lack of a structured transition program in our Burn Center was recognized as a contributing factor for nursing dissatisfaction and increased turnover compared to other hospital units. Employee evaluations exposed a need for more didactic instruction, hands-on learning, and preceptor support. The goal of this project was to implement an evidence-based transition to practice program specific to the burn specialty...
August 10, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28801463/shaping-health-policy-for-low-income-populations-an-assessment-of-public-comments-in-a-new-medicaid-waiver-process
#7
Marian Jarlenski, Philip Rocco, Renuka Tipirneni, Amy Jo Kennedy, Nivedita Gunturi, Julie Donohue
Since the Supreme Court decided that the Affordable Care Act's (ACA) Medicaid expansion is optional for the states, several have obtained federal approval to use Section 1115 waivers to expand Medicaid while changing its coverage and benefits design. There has long been concern that policy making for Medicaid populations may lack meaningful engagement with low-income constituents, and therefore the ACA established a new process under which the public can submit comments on pending Medicaid waiver applications...
August 11, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28797058/quantitative-approach-for-the-risk-assessment-of-african-swine-fever-and-classical-swine-fever-introduction-into-the-united-states-through-legal-imports-of-pigs-and-swine-products
#8
Diana María Herrera-Ibatá, Beatriz Martínez-López, Darla Quijada, Kenneth Burton, Lina Mur
The US livestock safety strongly depends on its capacity to prevent the introduction of Transboundary Animal Diseases (TADs). Therefore, accurate and updated information on the location and origin of those potential TADs risks is essential, so preventive measures as market restrictions can be put on place. The objective of the present study was to evaluate the current risk of African swine fever (ASF) and Classical swine fever (CSF) introduction into the US through the legal importations of live pigs and swine products using a quantitative approach that could be later applied to other risks...
2017: PloS One
https://www.readbyqxmd.com/read/28796019/incidence-of-serotonin-syndrome-with-combined-use-of-linezolid-and-serotonin-reuptake-inhibitors-compared-with-linezolid-monotherapy
#9
Diana C Karkow, Jill F Kauer, Erika J Ernst
PURPOSE: Linezolid is a monoamine oxidase inhibitor that may increase the risk of serotonin syndrome in patients receiving combination selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs). The objective of this study was to compare the incidence of serotonin syndrome when linezolid was administered alone and in combination with SSRIs or SNRIs. METHODS: This was a retrospective case-control study of adult inpatients admitted to the University of Iowa Hospitals and Clinics who received linezolid between January 2010 and December 2014...
August 8, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28791332/deep-brain-stimulation-of-the-subthalamic-nucleus-selectively-decreases-risky-choice-in-risk-preferring-rats
#10
Wendy K Adams, Cole Vonder Haar, Melanie Tremblay, Paul J Cocker, Mason M Silveira, Sukhbir Kaur, Christelle Baunez, Catharine A Winstanley
Deep brain stimulation of the subthalamic nucleus (STN-DBS) can improve the motor symptoms of Parkinson's disease (PD) and negate the problematic side effects of dopamine replacement therapy. Although there is concern that STN-DBS may enhance the development of gambling disorder and other impulse control disorders in this patient group, recent data suggest that STN-DBS may actually reduce iatrogenic impulse control disorders, and alleviate obsessive-compulsive disorder (OCD). Here, we sought to determine whether STN-DBS was beneficial or detrimental to performance of the rat gambling task (rGT), a rodent analogue of the Iowa Gambling Task (IGT) used to assess risky decision making clinically...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28783777/orthophosphorus-contributions-to-total-phosphorus-concentrations-and-loads-in-iowa-agricultural-watersheds
#11
Keith E Schilling, Sea-Won Kim, Christopher S Jones, Calvin F Wolter
Phosphorus (P) is delivered to streams as episodic particulate P and more continuous soluble P (orthophosphorus [OP]), and it is important to determine the proportion of each P form in river water to more effectively design remedial measures. In this study, we evaluated the annual mean ratios of OP to total P (TP) concentrations and loads in 12 Iowa rivers and found systematic variation in the ratios. The OP/TP ratios were >60% in two tile-drained watersheds of the Des Moines Lobe and in a shallow fractured bedrock watershed in northeast Iowa, whereas in southern and western Iowa, OP contributions to TP were <30%...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28782983/neurocognitive-dysfunction-in-addiction-testing-hypotheses-of-diffuse-versus-selective-phenotypic-dysfunction-with-a-classification-based-approach
#12
Warren K Bickel, Lara N Moody, Celia R Eddy, Christopher T Franck
Neurocognitive dysfunctions are frequently identified in the addictions. These dysfunctions may indicate either diffuse dysfunction or may represent separate facets that have differential importance to the addiction phenotype. In a sample (n = 260) of alcohol and/or stimulant users and controls we measured responses across 7 diverse neurocognitive measures. These measures were Continuous Performance, Delay Discounting, Iowa Gambling, Stroop, Tower, Wisconsin Card Sorting, and Letter Number Sequencing. Comparisons were then made between the drug-dependent groups and controls using analysis of variance and also using a machine learning approach to classify participants based on task performance as substance-dependent or controls in 1 tree and as alcohol and/or stimulant users or controls in a second tree...
August 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28774879/outcomes-in-refractory-diffuse-large-b-cell-lymphoma-results-from-the-international-scholar-1-study
#13
Michael Crump, Sattva S Neelapu, Umar Farooq, Eric Van Den Neste, John Kuruvilla, Jason Westin, Brian K Link, Annette Hay, James R Cerhan, Liting Zhu, Sami Boussetta, Lei Feng, Matthew J Maurer, Lynn Navale, Jeff Wiezorek, William Y Go, Christian Gisselbrecht
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Although 5-year survival rates in the first-line setting range from 60% to 70%, up to 50% of patients become refractory to or relapse after treatment. Published analyses of large-scale outcome data from patients with refractory DLBCL are limited. The international, multicohort retrospective non-Hodgkin lymphomaresearch (SCHOLAR-1) study retrospectively evaluated outcomes in patients with refractory DLBCL, which, for this study, was defined as progressive disease or stable disease as best response at any point during chemotherapy (>4 cycles of first-line or 2 cycles of later-line therapy) or relapsed ≤12 months of autologous stem cell transplantation...
August 3, 2017: Blood
https://www.readbyqxmd.com/read/28774607/case-study-approach-to-modeling-historical-disinfection-by-product-exposure-in-iowa-drinking-waters
#14
Stuart W Krasner, Kenneth P Cantor, Peter J Weyer, Mariana Hildesheim, Gary Amy
In the 1980s, a case-control epidemiologic study was conducted in Iowa (USA) to analyze the association between exposure to disinfection by-products (DBPs) and bladder cancer risk. Trihalomethanes (THMs), the most commonly measured and dominant class of DBPs in drinking water, served as a primary metric and surrogate for the full DBP mixture. Average THM exposure was calculated, based on rough estimates of past levels in Iowa. To reduce misclassification, a follow-up study was undertaken to improve estimates of past THM levels and to re-evaluate their association with cancer risk...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28771746/evaluation-of-enrollee-satisfaction-with-iowa-s-dental-wellness-plan-for-the-medicaid-expansion-population
#15
Julie C Reynolds, Susan C McKernan, Jennifer M C Sukalski, Peter C Damiano
BACKGROUND: Dental coverage for Iowa's Medicaid expansion population is provided through the Dental Wellness Plan (DWP), implemented in May 2014. The plan targets healthy behavior incentives via an earned benefits structure, whereby additional services are covered if enrollees return every 6-12 months for routine dental visits. This study examines enrollee satisfaction with the DWP. METHODS: We surveyed a random sample of DWP enrollees 1 year after program implementation about their experiences...
August 3, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28767613/effect-of-greater-trochanteric-epiphysiodesis-after-femoral-varus-osteotomy-for-lateral-pillar-classification-b-and-b-c-border-legg-calv%C3%A3-perthes-disease-a-retrospective-observational-study
#16
Keun-Sang Kwon, Sung Il Wang, Ju-Hyung Lee, Young Jae Moon, Jung Ryul Kim
This is a retrospective observational study. Greater trochanteric epiphysiodesis (GTE) has been recommended to prevent Trendelenburg gait and limitation of the hip joint motion due to trochanteric overgrowth after femoral varus osteotomy (FVO) in Legg-Calvé-Perthes disease (LCPD). However, capital femoral physeal arrest frequently occurs in patients with severe disease (lateral pillar C), so GTE might not be as effective in these patients. The aim of this study was to compare trochanteric growth inhibition due to GTE after FVO between 2 age groups (<8 or >8 years) in patients with lateral pillar B and B/C border LCPD and evaluate the effectiveness of GTE compared with the normal, unaffected hip...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766872/population-based-case-control-study-of-the-association-between-weather-related-extreme-heat-events-and-neural-tube-defects
#17
Aida Soim, Shao Lin, Scott C Sheridan, Syni-An Hwang, Wan-Hsiang Hsu, Thomas J Luben, Gary M Shaw, Marcia L Feldkamp, Paul A Romitti, Jennita Reefhuis, Peter H Langlois, Marilyn L Browne
BACKGROUND: Elevated body core temperature has been shown to have teratogenic effects in animal studies. Our study evaluated the association between weather-related extreme heat events (EHEs) in the summer season and neural tube defects (NTDs), and further investigated whether pregnant women with a high pregestational body mass index (BMI) have a greater risk of having a child with NTDs associated with exposure to EHE than women with a normal BMI. METHODS: We conducted a population-based case-control study among mothers of infants with NTDs and mothers of infants without major birth defects, who participated in the National Birth Defects Prevention Study and had at least 1 day of the third or fourth week postconception during summer months...
August 2, 2017: Birth defects research
https://www.readbyqxmd.com/read/28766121/estimation-of-tile-drainage-contribution-to-streamflow-and-nutrient-loads-at-the-watershed-scale-based-on-continuously-monitored-data
#18
A Arenas Amado, K E Schilling, C S Jones, N Thomas, L J Weber
Nitrogen losses from artificially drained watersheds degrade water quality at local and regional scales. In this study, we used an end-member mixing analysis (EMMA) together with high temporal resolution water quality and streamflow data collected in the 122 km(2) Otter Creek watershed located in northeast Iowa. We estimated the contribution of three end-members (groundwater, tile drainage, and quick flow) to streamflow and nitrogen loads and tested several combinations of possible nitrate concentrations for the end-members...
September 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28758817/the-validity-reliability-and-responsiveness-of-the-mosdified-iowa-level-of-assistance-scale-in-hospitalized-older-adults-in-subacute-care
#19
Sze-Ee Soh, Laura Stuart, Melissa Raymond, Lara Kimmel, Anne E Holland
OBJECTIVE: The objective of this study was to investigate the psychometric properties of the Modified Iowa Level of Assistance scale in hospitalized older adults in subacute care. DESIGN: A cohort, measurement-focused study. PARTICIPANTS AND SETTING: Fifty-eight older adults, aged 65 years and older, were recruited from a subacute rehabilitation hospital. METHODS: Inter-rater reliability was established by having two physiotherapists independently assess each participant within 24-h of each other...
July 31, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28756803/the-iowa-disinfection-cleaning-project-opportunities-successes-and-challenges-of-a-structured-intervention-program-in-56-hospitals
#20
Philip Carling, Loreen A Herwaldt
OBJECTIVE A diverse group of hospitals in Iowa implemented a program to objectively evaluate and improve the thoroughness of disinfection cleaning of near-patient surfaces. Administrative benefits of, challenges of, and impediments to the program were also evaluated. METHODS We conducted a prospective, quasi-experimental pre-/postintervention trial to improve the thoroughness of terminal room disinfection cleaning. Infection preventionists utilized an objective cleaning performance monitoring system (DAZO) to evaluate the thoroughness of disinfection cleaning (TDC) expressed as a proportion of objects confirmed to have been cleaned (numerator) to objects to be cleaned per hospital policy (denominator)×100...
August 2017: Infection Control and Hospital Epidemiology
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