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https://www.readbyqxmd.com/read/27914154/short-and-long-term-efficacy-of-laparoscopic-ovarian-diathermy-in-women-with-polycystic-ovary-syndrome
#1
Rita Luz, Joana Barros, Ana Aguiar, Cátia Rodrigues, Ana Paula Soares, Joaquim Nunes, Sandra Sousa, Carlos Calhaz-Jorge
INTRODUCTION: Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of spontaneous pregnancy. MATERIAL AND METHODS: This retrospective study involved 76 women who underwent laparoscopic ovarian diathermy between 2004 and 2013 in a university hospital...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27855085/comparison-of-acupuncture-pretreatment-followed-by-letrozole-versus-letrozole-alone-on-live-birth-in-anovulatory-infertile-women-with-polycystic-ovary-syndrome-a-study-protocol-for-a-randomised-controlled-trial
#2
Juan Li, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Zhenxing Hu, Wanting Wu, Maohua Lai, Taixiang Wu, Hongxia Ma
INTRODUCTION: The high prevalence of insulin resistance in women with polycystic ovary syndrome (PCOS) is considered to be one of the major pathophysiological changes in PCOS that leads to anovulatory infertility. We hypothesise that electroacupuncture pretreatment improves insulin sensitivity and leads to a higher ovulation rate and greater chances of live birth after the induction of ovulation. The effect of electroacupuncture pretreatment followed by ovulation induction in women with anovulatory PCOS has not been investigated before, and we present here a randomised controlled trial to test this hypothesis by comparing electroacupuncture pretreatment followed by letrozole versus letrozole alone in anovulatory women with PCOS...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27845161/downregulation-of-autophagy-gene-expression-in-endometria-from-women-with-polycystic-ovary-syndrome
#3
Mirjana Sumarac-Dumanovic, Milica Apostolovic, Kristina Janjetovic, Danka Jeremic, Dusan Popadic, Aleksandar Ljubic, Jelena Micic, Jelena Dukanac-Stamenkovic, Aleksandra Tubic, Darko Stevanovic, Dragan Micic, Vladimir Trajkovic
Autophagy, a process of controlled cellular self-digestion, could be involved in cyclic remodeling of the human endometrium. We investigated endometrial mRNA expression of 23 autophagy-related (ATG) genes and transcription factors in healthy controls (n = 12) and anovulatory polycystic ovary syndrome (PCOS) patients (n = 24), as well as in their subgroup (n = 12) before and after metformin treatment. The mRNA levels of transcription factor forkhead box protein O1 (FOXO1) and several molecules involved in autophagosome formation (ATG13, RB1-inducible coiled-coil 1), autophagosome nucleation (ATG14, beclin 1, SH3-domain GRB2-like endophilin B1), autophagosome elongation (ATG3, ATG5, γ-aminobutyric acid receptor-associated protein - GABARAP), and delivery of ubiquitinated proteins to autophagosomes (sequestosome 1), were significantly reduced in anovulatory PCOS compared to healthy endometrium...
November 11, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27843451/effects-of-inositol-s-in-women-with-pcos-a-systematic-review-of-randomized-controlled-trials
#4
REVIEW
Vittorio Unfer, John E Nestler, Zdravko A Kamenov, Nikos Prapas, Fabio Facchinetti
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with complex etiology and pathophysiology, which remains poorly understood. It affects about 5-10% of women of reproductive age who typically suffer from obesity, hyperandrogenism, ovarian dysfunction, and menstrual irregularity. Indeed, PCOS is the most common cause of anovulatory infertility in industrialized nations, and it is associated with insulin resistance, type 2 diabetes mellitus, and increased cardiovascular risk. Although insulin resistance is not included as a criterion for diagnosis, it is a critical pathological condition of PCOS...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27816236/elevated-circulating-micro-ribonucleic-acid-mirna-200b-and-mirna-429-levels%C3%A2-in-anovulatory-women
#5
Iris Eisenberg, Neta Nahmias, Michal Novoselsky Persky, Caryn Greenfield, Debra Goldman-Wohl, Arye Hurwitz, Ronit Haimov-Kochman, Simcha Yagel, Tal Imbar
OBJECTIVE: To study the role of micro-RNA (miRNA)-200b and miRNA-429 in human ovulation and to measure their expression levels in ovulatory and anovulatory patients. DESIGN: Micro-RNA-200b and miRNA-429 expression analysis in human serum and granulosa cells at different phases of the ovulation cycle in normal cycling women and women undergoing assisted reproductive technology cycles. SETTING: University-affiliated hospital and academic research laboratory...
November 2, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27798042/effectiveness-of-lifestyle-intervention-in-subgroups-of-obese-infertile-women-a-subgroup-analysis-of-a-rct
#6
A M van Oers, H Groen, M A Q Mutsaerts, J M Burggraaff, W K H Kuchenbecker, D A M Perquin, C A M Koks, R van Golde, E M Kaaijk, J M Schierbeek, G J E Oosterhuis, F J Broekmans, N E A Vogel, J A Land, B W J Mol, A Hoek
STUDY QUESTION: Do age, ovulatory status, severity of obesity and body fat distribution affect the effectiveness of lifestyle intervention in obese infertile women? SUMMARY ANSWER: We did not identify a subgroup in which lifestyle intervention increased the healthy live birth rate however it did increase the natural conception rate in anovulatory obese infertile women. WHAT IS KNOWN ALREADY: Obese women are at increased risk of infertility and are less likely to conceive after infertility treatment...
October 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27783532/thermosensitive-bioadhesive-gels-for-the-vaginal-delivery-of-sildenafil-citrate-in-vitro-characterization-and-clinical-evaluation-in-women-using-clomiphene-citrate-for-induction-of-ovulation
#7
Ghareb M Soliman, Gihan Fetih, Ahmed M Abbas
OBJECTIVE: The objective of this study is to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of endometrial thinning occurring as a result of using clomiphene citrate for ovulation induction in women with type II eugonadotrophic anovulation. While sildenafil has shown promising results in the treatment of infertility in women, the lack of vaginal pharmaceutical preparation and the side effects associated with oral sildenafil limit its clinical effectiveness...
November 14, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27753169/body-condition-and-stage-of-seasonal-anestrus-interact-to-determine-the-ovulatory-response-after-male-biostimulation-in-anovulatory-criollo-%C3%A3-nubian-goats
#8
Hector R Vera-Avila, Jorge Urrutia-Morales, Mario A Espinosa-Martinez, Hector G Gamez-Vazquez, Hector Jimenez-Severiano, Eugenio Villagomez-Amezcua
The effect of goat nutritional condition on the response to biostimulation with sexually active males during different stages of anestrus was determined. Fifty-eight Criollo × Nubian females on high and low body mass index (BMI) diets were used. Each BMI group was divided into two for biostimulation with sexually active males during May (mid-anestrus) or July (transition period). Ovulatory responses to biostimulation were characterized from serum progesterone, as well as the delay for response (first and second ovulations followed by a normal length luteal phase, O-WNLP)...
October 17, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27733131/co-morbidity-of-cervical-incompetence-with-polycystic-ovarian-syndrome-pcos-negatively-impacts-prognosis-a-retrospective-analysis-of-178-patients
#9
Yongqing Wang, Xunke Gu, Liyuan Tao, Yangyu Zhao
BACKGROUND: Cervical incompetence is an important cause of miscarriage and premature birth and polycystic ovary syndrome is a heterogeneous endocrine disorder that is the most common cause of anovulatory infertility and eugonadotrophic hypogonadism. By now, it is still debated whether women with PCOS have an increased risk of miscarriage and there have been no studies about the pregnancy outcomes of cervical incompetence patients with PCOS. METHODS: The following clinical data of cervical incompetence patients with/without PCOS who were treated between September 2006 and September 2013 were retrospectively analysed: onset gestational age, termination gestational age, pregnancy outcome, co-morbid insulin resistance (IR) in PCOS patients, the influence of IR, co-morbid hyperandrogenism (HA) in PCOS patients, and the influence of HA...
October 12, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27720155/physiological-predictors-of-ovulation-and-pregnancy-risk-in-a-fixed-time-artificial-insemination-program
#10
J S Stevenson
The objective of this study was to determine the relative importance and contribution of several physiological factors as predictors of pregnancy risk in an Ovsynch (GnRH-1 - 7 d - PGF2α - 56 h - GnRH-2 - 16 h - artificial insemination) timed artificial insemination program: (1) age of the corpus luteum (CL; original CL, new CL, or both in response to GnRH-1) and resulting progesterone concentrations as they affected luteolysis, ovulation after GnRH-2, and pregnancy risk; (2) progesterone concentration before GnRH-1 and GnRH-2 on subsequent ovulatory response to GnRH-1 and GnRH-2 as well as pregnancy risk; and (3) a combination of these factors in a multivariable logistic regression model to predict pregnancy risk...
October 5, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27665725/kisspeptin-mrna-expression-is-increased-in-the-posterior-hypothalamus-in-the-rat-model-of-polycystic-ovary-syndrome
#11
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Takeshi Iwasa, Munkhsaikhan Munkhzaya, Rie Yanagihara, Takako Tokui, Kiyohito Yano, Yiliyasi Mayila, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Hypersecretion of luteinizing hormone (LH) is a common endocrinological finding of polycystic ovary syndrome (PCOS). This derangement might have a close relationship with hypothalamic kisspeptin expression that is thought to be a key regulator of gonadotropin-releasing hormone (GnRH). We evaluated the relationship between the hypothalamic-pituitary-gonadal axis (HPG axis) and kisspeptin using a rat model of PCOS induced by letrozole. Letrozole pellets (0.4 mg/day) and control pellets were placed subcutaneously onto the backs of 3-week-old female Wistar rats...
September 24, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27651637/gynecological-problems-of-adolescent-girls-attending-outpatient-department-at-tertiary-care-center-with-evaluation-of-cases-of-puberty-menorrhagia-requiring-hospitalization
#12
Archana D Rathod, Rohidas P Chavan, Sandhya P Pajai, Vijay Bhagat, Prachi Thool
ABSTRACT: Adolescence is a period of enormous physical and psychological change for young girls. Many adolescents with menstrual disturbances never present to their family doctor or gynecologist. Embarrassment about discussing menstruation, fear of disease, and ignorance about services available may lead to delayed presentation or consultation with doctor. AIMS AND OBJECTIVE: To evaluate the different gynecological problems in adolescent girls attending outpatient department...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27629906/appetitive-and-consummatory-sexual-behaviors-of-rams-treated-with-exogenous-testosterone-and-exposed-to-anestrus-dorper-ewes-efficacy-of-the-male-effect
#13
Luz M Tejada, Cesar A Meza-Herrera, Raymundo Rivas-Muñoz, Rafael Rodríguez-Martínez, Evaristo Carrillo, Miguel Mellado, Francisco G Véliz-Deras
We determine whether Dorper rams treated with testosterone in the sexual resting season trigger both appetitive and consummatory sexual behaviors and sexual and reproductive outcomes in anestrous ewes at 26° North during March-April. Dorper rams (n = 12, 2.5 years) were randomly divided prior to mating in two groups: GT (treated group; n = 6), treated with testosterone propionate (25 mg i.m. every 3 days × 3 weeks) and GC (control group; n = 6), treated with saline. Thereafter, adult anovulatory Dorper ewes (n = 61) were exposed to the GT-rams while the other group (n = 60) was exposed to the GC-rams...
September 14, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27629133/comparison-of-uterine-endometrial-and-ovarian-blood-flow-by-transvaginal-color-doppler-ultrasound-in-ovulatory-and-anovulatory-cycles
#14
Ozan Dogan, Ahmet Yildiz, Osman Temizkan, Cigdem Pulatoglu
OBJECTIVES: Blood flow to uterus and ovaries is demonstrated to be altered during mensturation. Studies has been published stating that blood flow differs also in ovulatory and anovulatory cycles. In this study, using color Doppler ultrasound, we aim to compare uterine, endometrial and ovarian blood flow during ovulatory and anovulatory cycles. MATERIAL AND METHODS: Women volunteers who are aged between 18-40 had no endocrinological problem and not recieving exogenous hormone therapy were included to study...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27627603/the-impact-of-ovarian-stimulation-on-the-outcome-of-intrauterine-insemination-treatment-an-analysis-of-8893-cycles
#15
Jinyong Liu, Tin-Chiu Li, Jing Wang, Wei Wang, Zhen Hou, Jiayin Liu
OBJECTIVE: To evaluate the impact of ovarian stimulation on the outcome of intrauterine insemination (IUI). DESIGN: Retrospective analysis. SETTING: A single university-based centre. POPULATION: A total of 5109 couples with 8893 cycles. METHODS: The outcome of IUI with different protocols for ovarian stimulation was examined. MAIN OUTCOME MEASURES: The live birth rate (LBR), twin pregnancy rate and ovarian hyperstimulation syndrome (OHSS)...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27601321/in-vivo-and-in-vitro-maturation-of-oocytes-collected-from-superstimulated-wood-bison-bison-bison-athabascae-during-the-anovulatory-and-ovulatory-seasons
#16
Miriam P Cervantes, J Manuel Palomino, Muhammad Anzar, Reuben J Mapletoft, Gregg P Adams
Experiments were done to compare the in vivo and in vitro maturational characteristics of cumulus-oocyte complexes (COC) collected from live wood bison. In Experiment 1 (anovulatory season), follicular ablation was done to synchronize follicle wave emergence among bison on Day -1, and FSH was given on Days 0 and 2. Bison were then assigned to 5 groups (n=5/group) in which COC were collected by transvaginal follicle aspiration on Day 4 and either fixed immediately with no maturation (control), matured in vitro for 24 or 30h, or collected on Day 5 after in vivo maturation for 24 or 30h (i...
October 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27560548/evolution-of-the-hypothalamic-pituitary-gonadal-axis-regulation-in-vertebrates-revealed-by-knockout-medaka
#17
Akiko Takahashi, Shinji Kanda, Tomohiro Abe, Yoshitaka Oka
Reproduction is essential for life, but its regulatory mechanism is diverse. The analysis of this diversity should lead us to understand the evolutionary process of the regulation of reproduction. In mammals, the hypothalamic-pituitary-gonadal axis plays an essential role in such regulation, and each component, hypothalamic GnRH, and pituitary gonadotropins, LH, and FSH, is indispensable. However, the common principle of the hypothalamic-pituitary-gonadal axis regulation among vertebrates remains unclear. Here, we used a teleost medaka, which is phylogenetically distant from mammals, and analyzed phenotypes of gene knockouts (KOs) for GnRH, LH, and FSH...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27543788/endocrine-disrupting-chemicals-and-ovulation-is-there-a-relationship
#18
Mia V Gallo, Julia Ravenscroft, David O Carpenter, Cheryl Frye, Akwesasne Task Force On The Environment, Beverly Cook, Lawrence M Schell
Although the potential for endocrine disrupting chemicals (EDCs) to disrupt female fecundity is great, few studies have assessed the threat to human reproduction. This study investigates levels of organochlorines in relation to their impact on women's menstrual cycles and ovulatory status. To address concerns of the Akwesasne Mohawk community in upstate New York regarding well-established exposure to EDCs, women's fertility and reproductive health endpoints, we recruited 215 women between the ages of 21 and 38 years to measure menstrual cycle characteristics and levels of local pollutants...
August 17, 2016: Environmental Research
https://www.readbyqxmd.com/read/27511809/the-management-of-anovulatory-infertility-in-women-with-polycystic-ovary-syndrome-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance
#19
REVIEW
Adam H Balen, Lara C Morley, Marie Misso, Stephen Franks, Richard S Legro, Chandrika N Wijeyaratne, Elisabet Stener-Victorin, Bart C J M Fauser, Robert J Norman, Helena Teede
BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS...
November 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27498530/algorithm-of-ovulation-induction-in-patients-with-polycistic-ovary-syndrome
#20
REVIEW
Artur Bjelica, Jelena Bjelanović, Natasa Milić, Ljiljana Mladenović Segedi, Đorde Ilić, Jelena Dimitrijević
INTRODUCTION: Polycystic ovary syndrome is the most frequent endocrine disturbance in the reproductive period of women's life and the most frequent cause of anovulatory infertility. Ovulation and pregnancy in patients having polycystic ovary syndrome may be a result of a wide range of therapeutic options, and the treatment assumes a gradual approach--from simple noninvasive to expensive and demanding procedures. MATERIAL AND METHODS: A systematic literature survey concerning the efficiency of particular ovulation induction methods in respect of the reproductive outcome was carried out with the aim of establishing the algorithm for ovulation induction in infertile patients having polycystic ovary syndrome...
January 2016: Medicinski Pregled
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