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JOURNAL ARTICLE
Jingjing Cai, Xiangmin Luo, Zhengyao Wang, Zixuan Chen, Donghong Huang, Hui Cao, Jing Chen, Jinxiang Wu
BACKGROUND: Polycystic ovary syndrome (PCOS) is main cause of anovulatory infertility in women with gestational age. There are currently four distinct phenotypes associated with individualized endocrinology and metabolism. Growth differentiation factor 9 (GDF9) is a candidate as potential biomarker for the assessment of oocyte competence. The effect on oocyte capacity has not been evaluated and analyzed in PCOS phenotypes. OBJECTIVE: We aimed to screen the expression levels of GDF9 in mature follicles of women with controlled ovarian hyperstimulation (COS) with different PCOS phenotypes...
May 15, 2024: Heliyon
#2
JOURNAL ARTICLE
Kanchan Rani, Kante Durga Mounika, Shivangi Singhal
Introduction There have been numerous studies on the anovulatory factor, leading to infertility in women with polycystic ovary syndrome (PCOS); however, studies on the endometrium factor causing infertility in PCOS women are scarce. While hysteroscopy can accurately diagnose endometrial disorders such as endometrial polyps, it may be ineffective in detecting probable endometrial pathologies due to different hormonal habitats in these patients. Materials and methods Sixty patients with PCOS-related infertility were included in the study...
April 2024: Curēus
#3
RANDOMIZED CONTROLLED TRIAL
Jennifer K Y Ko, Sofie S F Yung, Shui Fan Lai, Rebecca S F Wan, Catherine K Y Wong, Keedon Wong, Ching-Lung Cheung, Ernest H Y Ng, Raymond H W Li
INTRODUCTION: Low vitamin D status is prevalent among women with polycystic ovary syndrome (PCOS). The objective of the study is to assess the effect of vitamin D supplementation on (1) the ovulation rate to letrozole and (2) other reproductive, endocrine and metabolic outcomes after 1 year of supplementation in women with PCOS. METHODS AND ANALYSIS: This is a multicentre, randomised, double-blind, controlled clinical trial. A total of 220 anovulatory women with PCOS diagnosed by the Rotterdam criteria will be recruited...
April 29, 2024: BMJ Open
#4
JOURNAL ARTICLE
Li Yu, Chen Wang, Miao Liu, Lingjin Xia, Te Liu, Qi Che, Wei Cai, Xi Dong, Baishen Pan, Beili Wang, Suying Liu, Wei Guo
OBJECTIVE: Women who are of reproductive age can suffer from polycystic ovary syndrome (PCOS), an endocrine disorder. Anovulatory infertility is mostly caused by aberrant follicular development, which is seen in PCOS patients. Due to the dysfunction of reproductive and endocrine function in PCOS patients, assisted reproduction treatment is one of the main means to obtain clinical pregnancy for PCOS patients. Long non-coding RNA (lncRNA) as a group of functional RNA molecules have been found to participate in the regulation of oocyte function, hormone metabolism, and proliferation and apoptosis of granulosa cells...
April 24, 2024: Journal of Assisted Reproduction and Genetics
#5
JOURNAL ARTICLE
S Borchardt, T A Burnett, W Heuwieser, J L Plenio, R S Conceição, R L A Cerri, A M L Madureira
The objective of this observational study was to evaluate the efficacy of a neck-mounted automated activity monitor (AAM) at detecting early postpartum resumed ovarian cyclicity. A total of 192 lactating cows (primiparous = 73 and multiparous = 119) were enrolled in this study. Cows were continuously monitored by a neck-mounted AAM early postpartum (7 to 30 d in milk; DIM). Calving was classified as assisted (forced extraction of a calf) or unassisted (normal calving). Retained fetal membrane, metritis, hyperketonemia, clinical mastitis, and milk production were recorded...
May 2024: JDS Commun
#6
REVIEW
Elisabet Stener-Victorin, Helena Teede, Robert J Norman, Richard Legro, Mark O Goodarzi, Anuja Dokras, Joop Laven, Kathleen Hoeger, Terhi T Piltonen
Despite affecting ~11-13% of women globally, polycystic ovary syndrome (PCOS) is a substantially understudied condition. PCOS, possibly extending to men's health, imposes a considerable health and economic burden worldwide. Diagnosis in adults follows the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome, requiring two out of three criteria - clinical or biochemical hyperandrogenism, ovulatory dysfunction, and/or specific ovarian morphological characteristics or elevated anti-Müllerian hormone...
April 18, 2024: Nature Reviews. Disease Primers
#7
JOURNAL ARTICLE
David Ruiz-González, Iván Cavero-Redondo, Alba Hernández-Martínez, Andrés Baena-Raya, Sonia Martínez-Forte, Signe Altmäe, Ana M Fernández-Alonso, Alberto Soriano-Maldonado
BACKGROUND: The increasing prevalence of obesity worldwide poses a significant threat to reproductive function owing, in part, to hormonal disturbances caused by negative feedback between excess adiposity and the hypothalamic-pituitary-ovarian axis. Consequently, finding the most appropriate strategies to lose weight and improve ovulation in women with overweight or obesity is a clinically relevant matter that needs to be investigated. A comprehensive comparison of the independent and combined efficacy of lifestyle and/or pharmacological interventions on BMI, ovulation, and hormonal profile in women with overweight or obesity at risk of anovulatory infertility would facilitate improving fertility strategies in this population...
April 16, 2024: Human Reproduction Update
#8
JOURNAL ARTICLE
Gitika Katyal, Gursharan Kaur, Hafsa Ashraf, Adiprasad Bodapati, Ayesha Hanif, Donatus Kaine Okafor, Safeera Khan
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among reproductive-age women. As a leading cause of anovulatory infertility, it complicates fertility treatments, including in vitro fertilization. The widely accepted 2003 Rotterdam diagnostic criteria for PCOS include sub-phenotypes based on variations in androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. In this systematic review, we examined the impacts of inositol and vitamin D on fertility in PCOS. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, we used relevant keywords to comprehensively search databases including PubMed, Google Scholar, and MDPI...
April 11, 2024: Clinical and Experimental Reproductive Medicine
#9
JOURNAL ARTICLE
Ana Clara Sarzedas Ribeiro, Pedro Henrique Nicolau Pinto, Juliana Dantas Rodrigues Santos, Nadiala Porto Ramalho, Camila Correa Roza Laeber, Mario Felipe Alvarez Balaro, Ribrio Ivan Tavares Pereira Batista, Joanna Maria Gonçalves Souza-Fabjan, Jeferson Ferreira da Fonseca, Rodolfo Ungerfeld, Felipe Zandonadi Brandão
This study compared the follicular growth, superovulatory response, and in vivo embryo production after administering two doses of porcine follicle-stimulating hormone (pFSH) in Santa Inês ewes. The estrous cycle of 36 multiparous ewes was synchronized with the Day 0 protocol and superovulated with 133 mg (G133, n=18) or 200 mg (G200, n=18) of pFSH. Ultrasonographic evaluations of the ovaries were performed, ewes were mated and submitted to non-surgical embryo recovery. Viable blastocysts were stained with Nile Red and Hoechst...
March 27, 2024: Animal Reproduction Science
#10
Samvida S Venkatesh, Laura B L Wittemans, Duncan S Palmer, Nikolas A Baya, Teresa Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie T Bruun, Christian Erikstrup, Bitten A Jensen, Anders Juul, Christina Mikkelsen, Henriette S Nielsen, Sisse R Ostrowski, Ole B Pedersen, Palle D Rohde, Erik Sorensen, Henrik Ullum, David Westergaard, Asgeir Haraldsson, Hilma Holm, Ingileif Jonsdottir, Isleifur Olafsson, Thora Steingrimsdottir, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Jessica Figueredo, Minna K Karjalainen, Anu Pasanen, Benjamin M Jacobs, Nikki Hubers, Margaret Lippincott, Abigail Fraser, Deborah A Lawlor, Nicholas J Timpson, Mette Nyegaard, Kari Stefansson, Reedik Magi, Hannele Laivuori, David A van Heel, Dorret I Boomsma, Ravikumar Balasubramanian, Stephanie B Seminara, Yee-Ming Chan, Triin Laisk, Cecilia M Lindgren
Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 687,005 controls. We identified 21 genetic risk loci for infertility ( P ≤5E-08), of which 12 have not been reported for any reproductive condition. We found positive genetic correlations between endometriosis and all-cause female infertility ( r g =0.585, P =8.98E-14), and between polycystic ovary syndrome and anovulatory infertility ( r g =0...
March 20, 2024: medRxiv
#11
JOURNAL ARTICLE
Soudabeh Kavousipour, Fahimeh Koohnavard, Behzad Shahbazi, Ebrahim Eftekhar, Khadijeh Ahmadi
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The aim of this study was to investigate the therapeutic potential of vitamin C, glutamine, mesalazine, hydralazine, and alendronate as new drug candidates for the treatment of letrozole-induced PCOS in female Wistar rats. PCOS was induced in rats by intramuscular injection of estradiol valerate (2 mg/kg body weight for 28 days). The rats then received normal saline (PCOS group), letrozole (0.5 mg/kg), vitamin C (100 mg/kg), glutamine (1000 mg/kg), mesalazine (200 mg/kg), hydralazine (30 mg/kg), and alendronate (17...
March 28, 2024: Biomedicine & Pharmacotherapy
#12
JOURNAL ARTICLE
Xinyu Li, Yunying Lin, Xiaoyue Cheng, Guangxin Yao, Jufang Yao, Shuanggang Hu, Qinling Zhu, Yuan Wang, Ying Ding, Yao Lu, Jia Qi, Hanting Zhao, Xuejiao Bian, Yanzhi Du, Kang Sun, Hugo Vankelecom, Yun Sun
STUDY QUESTION: Does ovarian ferroptosis play an active role in the development of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Increased ovarian ferroptosis was present in PCOS ovaries and the inhibition of ferroptosis with ferrostatin-1 (Fer-1) ameliorated polycystic ovary morphology and anovulation. WHAT IS KNOWN ALREADY: Programmed cell death plays a fundamental role in ovarian follicle development. However, the types and mechanisms of cell death involved in the ovary are yet to be elucidated...
2024: Human Reproduction Open
#13
REVIEW
Ping Zhou, Penghui Feng, Baoying Liao, Lin Fu, Hongying Shan, Canhui Cao, Renxin Luo, Tianliu Peng, Fenting Liu, Rong Li
Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut...
March 27, 2024: Journal of Ovarian Research
#14
JOURNAL ARTICLE
Shaojing He, Hui Li, Qianjie Zhang, Weimin Zhao, Wei Li, Chaohui Dai, Bixia Li, Jinhua Cheng, Shuang Wu, Zhongming Zhou, Jing Yang, Saijiao Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic and endocrine disorder that causes anovulatory infertility and abnormal folliculogenesis in women of reproductive age. Several studies have revealed inflammation in PCOS follicles, and recent evidence suggests that Berberine (BBR) effectively reduces inflammatory responses in PCOS, however, the underlying mechanisms remain unclear. PURPOSE: To determine the underlying mechanisms by which BBR alleviates inflammation in PCOS...
February 15, 2024: Phytomedicine
#15
JOURNAL ARTICLE
Z Wang, M Van Faassen, H Groen, A E P Cantineau, A Van Oers, A Van der Veen, J M Hawley, B G Keevil, I P Kema, A Hoek
STUDY QUESTION: Is resumption of ovulation after a 6-month lifestyle intervention in women with PCOS and obesity associated with differential changes in endocrine and metabolic parameters (weight, insulin resistance, anti-Müllerian hormone (AMH), and androgens) compared to women with PCOS who remained anovulatory? SUMMARY ANSWER: Resumption of ovulation after a 6-month lifestyle intervention in women with PCOS and obesity is associated with changes in serum 11β-hydroxyandrostenedione (11OHA4) concentrations...
March 19, 2024: Human Reproduction
#16
JOURNAL ARTICLE
Yi Yang, Lihua Jin, Shasha Xu, Huijun Ye, Xi Luo, Ruilan Li, Yuebing Yue
RATIONALE: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder among women of childbearing age and is the primary cause of anovulatory infertility, accounting for 70% to 80% of cases. Ovulation induction is the main treatment approach for infertile patients with PCOS. Commonly utilized medications for this purpose are clomiphene citrate (CC) and letrozole (LE). Clomiphene citrate administration results in an ovulation rate ranging from 60% to 85%, while the pregnancy rate is limited to 35% to 40%, and a further reduction is observed in live birth rates...
March 8, 2024: Medicine (Baltimore)
#17
JOURNAL ARTICLE
Seungbaek Lee, Riikka K Arffman, Elina K Komsi, Outi Lindgren, Janette Kemppainen, Keiu Kask, Merli Saare, Andres Salumets, Terhi T Piltonen
BACKGROUND: The human endometrium undergoes a monthly cycle of tissue growth and degeneration. During the mid-secretory phase, the endometrium establishes an optimal niche for embryo implantation by regulating cellular composition (e.g., epithelial and stromal cells) and differentiation. Impaired endometrial development observed in conditions such as polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF) contributes to infertility. Surprisingly, despite the importance of the endometrial lining properly developing prior to pregnancy, precise measures of endometrial cellular composition in these two infertility-associated conditions are entirely lacking...
December 2024: Journal of Pathology Informatics
#18
JOURNAL ARTICLE
B M McGrath, S T Norman, C A Gaspardis, J L Rose, C J Scott
To understand better the role that kisspeptin plays in regulating seasonal and estrous cycle changes in the mare, this study investigated the number, location and interactions between GnRH, kisspeptin and RFRP-3 neurons in the equine hypothalamus. Hypothalami were collected from mares during the non-breeding season, vernal transition and various stages of the breeding season. Fluorescent immunohistochemistry was used to label the neuropeptides of interest. GnRH cells were observed primarily in the arcuate nucleus (ARC), while very few labeled cells were identified in the pre-optic area (POA)...
February 27, 2024: Theriogenology
#19
REVIEW
Eva Dreisler, Christian Seerup Frandsen, Lian Ulrich
Abnormal uterine bleeding is a frequent symptom in the perimenopause. Causes are numerous, ranging from physiological reactions due to decreasing/unstable ovarian function to premalignant and malignant conditions. Benign findings such as endometrial polyps and myomas increase with age, leading to more abnormal uterine bleeding in the perimenopause. Cervical and vaginal causes of abnormal uterine bleeding should be excluded by speculum examination. Sexually transmitted diseases or pregnancy should be ruled out...
February 22, 2024: Maturitas
#20
JOURNAL ARTICLE
M Blake Evans, Pardis Hosseinzadeh, Kerry Flannagan, Samad Jahandideh, Emilie Burruss, Jennifer D Peck, Karl R Hansen, Micah Hill, Kate Devine
OBJECTIVE: To study the primary objective of clinical pregnancy (CP) rate per ovarian stimulation with intrauterine insemination (OS-IUI) treatment cycle in patients with repetitive cycles up to a maximum of 8 cycles. DESIGN: Retrospective cohort. SETTING: Large fertility clinic. PATIENTS: A total of 37,565 consecutive OS-IUI cycles from 18,509 patients were included in this study. INTERVENTIONS: Those with anovulatory diagnoses, tubal factor infertility, male factor infertility, using donor sperm, canceled cycles, and those with missing data for either baseline characteristics or outcome were excluded...
February 15, 2024: Fertility and Sterility
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