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https://www.readbyqxmd.com/read/29747700/effects-of-myo-inositol-plus-alpha-lactalbumin-in-myo-inositol-resistant-pcos-women
#1
Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno, Vittorio Unfer
BACKGROUND: Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also considering its anti-inflammatory effect. METHODS: PCOS patients, according to the Rotterdam ESHRE-ASRM criteria, with anovulation and infertility > 1 year, were included in this open and prospective study. The preliminary phase was aimed at determining a set of MI-resistant PCOS patients...
May 10, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29743106/the-foam-study-is-hysterosalpingo-foam-sonography-hyfosy-a-cost-effective-alternative-for-hysterosalpingography-hsg-in-assessing-tubal-patency-in-subfertile-women-study-protocol-for-a-randomized-controlled-trial
#2
Joukje van Rijswijk, Nienke van Welie, Kim Dreyer, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, Kimiko A Kleiman-Broeze, Maaike A F Traas, Guido J J M Muijsers, Arentje P Manger, Judith Gianotten, Cornelia H de Koning, Aafke M H Koning, Neriman Bayram, David P van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusova, Bob I G van de Laar, Jeroen Kaijser, Miriam F van Oostwaard, Wouter J Meijer, Frank J M Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J Lambers, Henrike E Peters, Marit C I Lier, Cornelis B Lambalk, Madelon van Wely, Patrick M M Bossuyt, Jaap Stoker, Fulco van der Veen, Ben W J Mol, Velja Mijatovic
BACKGROUND: Tubal pathology is a causative factor in 20% of subfertile couples. Traditionally, tubal testing during fertility work-up is performed by hysterosalpingography (HSG). Hysterosalpingo-foam sonography (HyFoSy) is a new technique that is thought to have comparable accuracy as HSG, while it is less expensive and more patient friendly. HyFoSy would be an acceptable alternative for HSG, provided it has similar effectiveness in terms of patient outcomes. METHODS/DESIGN: We aim to compare the effectiveness and costs of management guided by HyFoSy or by HSG...
May 9, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29739821/c-type-natriuretic-peptide-a-link-between-hyperandrogenism-and-anovulation-in-a-mouse-model-of-polycystic-ovary-syndrome
#3
Adelina M Reis, Kinulpe Honorato-Sampaio
The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. Despite the great amount of research in the area, mechanisms involved in the genesis of this syndrome remain poorly understood. In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen...
May 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29695075/update-on-multiple-ovulations-in-dairy-cattle
#4
REVIEW
Kira Macmillan, John P Kastelic, Marcos G Colazo
This review updates the causal mechanisms and risk factors for multiple ovulations (MOV) in cattle. Clearly, MOV can lead to twin pregnancies, which negatively affects the health, production, and reproduction of cows. Therefore, a better understanding of the factors causing MOV may help to reduce twinning. Multiple ovulations occur after two or more follicles deviate and achieve codominance. The MOV rate is influenced by a complex network of hormones. For example, MOV is more common during periods of low progesterone (P4), that is, in anovulatory cattle or when luteolysis coincides with the selection of the future ovulatory follicle...
April 24, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29682816/subtropical-goats-ovulate-in-response-to-the-male-effect-after-a-prolonged-treatment-of-artificial-long-days-to-stimulate-their-milk-yield
#5
E S Mendieta, J A Delgadillo, J A Flores, M J Flores, E Nandayapa, L I Vélez, L A Zarazaga, M Bedos, A Terrazas, H Hernández
The objectives of this study were to determine (i) if in subtropical goats that gave birth during mid-December, the exposition to an artificial long-day photoperiod consisting in only 14 hr of light per day can increase the milk yield and (ii) to test whether these females can respond to the male effect at the end of the prolonged photoperiodic treatment. In experiment 1, 17 lactating goats were maintained under natural short days (control group), while another 22 goats were maintained under artificial long days (treated group) consisting in 14 hr light and 10 hr darkness starting at day 10 of lactation...
April 22, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29670770/genetic-variants-associated-with-hyperandrogenemia-in-pcos-pathophysiology
#6
REVIEW
Roshan Dadachanji, Nuzhat Shaikh, Srabani Mukherjee
Polycystic ovary syndrome is a multifactorial endocrine disorder whose pathophysiology baffles many researchers till today. This syndrome is typically characterized by anovulatory cycles and infertility, altered gonadotropin levels, obesity, and bulky multifollicular ovaries on ultrasound. Hyperandrogenism and insulin resistance are hallmark features of its complex pathophysiology. Hyperandrogenemia is a salient feature of PCOS and a major contributor to cosmetic anomalies including hirsutism, acne, and male pattern alopecia in affected women...
2018: Genetics Research International
https://www.readbyqxmd.com/read/29659847/follicle-growth-and-endocrine-dynamics-in-women-with-spontaneous-luteinized-unruptured-follicles-versus-ovulation
#7
S T Bashir, A R Baerwald, M O Gastal, R A Pierson, E L Gastal
STUDY QUESTION: Do growth patterns and endocrine profiles differ between ovulatory follicles (OvFs) and luteinized unruptured follicles (LUFs) in women? SUMMARY ANSWER: Growth rates, diameters and associated endocrine profiles differed between OvFs and LUFs in unstimulated cycles. WHAT IS KNOWN ALREADY: Two-three waves of antral follicles develop during the menstrual cycle in ovulatory women of reproductive age, with the second or third wave terminating in ovulation...
April 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29604466/pon1-promoter-polymorphisms-contribute-to-pcos-susceptibility-and-phenotypic-outcomes-in-indian-women
#8
Roshan Dadachanji, Nuzhat Shaikh, Anushree Patil, Nalini Shah, Srabani Mukherjee
Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperandrogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only -907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model...
March 28, 2018: Gene
https://www.readbyqxmd.com/read/29595066/follicular-fluid-levels-of-anti-m%C3%A3-llerian-hormone-insulin-like-growth-factor-1-and-leptin-in-women-with-fertility-disorders
#9
Radek Kucera, Vaclav Babuska, Zdenka Ulcova-Gallova, Vlastimil Kulda, Ondrej Topolcan
Anti-Müllerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason...
March 29, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29560149/effect-of-metformin-on-the-anti-m%C3%A3-llerian-hormone-level-in-infertile-women-with-polycystic-ovarian-syndrome
#10
Fatemeh Foroozanfard, Mansooreh Samimi, Kosar Hosseini Almadani, Mojtaba Sehat
Background: Polycystic ovary syndrome (PCOS) is the major cause of anovulatory infertility in women. The level of serum Anti-Mullerian Hormone (AMH) in patients can be 2-3 times higher than in healthy women. The aim of this study was to assess the effect of metformin on AMH level in PCOS patients suffering from infertility. Methods: In this pre and post clinical trial, 30 infertile patients with PCOS were enrolled according to the Rotterdam criteria. The serum AMH level was recorded before and after 8 weeks of treatment with metformin (1500 mg daily)...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29537383/abnormal-uterine-bleeding-in-adolescents
#11
Selin Elmaoğulları, Zeyra Aycan
Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Additionally, endocrine disorders such as hypothyroidism, hyperprolactinemia and polycystic ovary syndrome (PCOS) are possible causes of AUB...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29518757/prevalence-pathogenesis-and-management-of-prediabetes-and-type-2-diabetes-mellitus-in-patients-with-polycystic-ovary-syndrome
#12
REVIEW
Sofia Lazaridou, Konstantinos Dinas, Konstantinos Tziomalos
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. PCOS is not only the leading cause of anovulatory infertility but is also associated with an array of metabolic disorders, among which impaired glucose metabolism has been a topic of intense research. The aim of the present narrative review is to summarize the findings of the studies that have evaluated the prevalence and incidence of prediabetes and type 2 diabetes mellitus (T2DM) in patients with PCOS, to analyze the factors underpinning the association between T2DM and PCOS and to discuss the current strategies for screening and management of impaired glucose metabolism in this population...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29459401/low-dose-gonadotropin-induction-of-ovulation-in-anovulatory-women-still-needed-in-the-age-of-ivf
#13
Davinia White, Kate Hardy, Suzannah Lovelock, Stephen Franks
Low-dose, step-up gonadotropin is the treatment of choice for women with PCOS who have not conceived after anti-estrogen treatment, and as an effective alternative to pulsatile GnRH in women with hypogonadotropic hypogonadism (HH). There has been, however, no large-scale, comparative study between the two groups using low-dose gonadotropins. Here we performed a retrospective, comparative analysis, in a single clinic database, of efficacy and safety of induction of ovulation using low-dose gonadotropins in 364 Women with PCOS and 80 women with HH...
February 19, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29428315/association-of-testosterone-and-antim%C3%A3-llerian-hormone-with-time-to-pregnancy-and-pregnancy-loss-in-fecund-women-attempting-pregnancy
#14
Lindsey A Sjaarda, Sunni L Mumford, Daniel L Kuhr, Tiffany L Holland, Robert M Silver, Torie C Plowden, Neil J Perkins, Enrique F Schisterman
OBJECTIVE: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. DESIGN: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial. SETTING: University medical centers. PATIENT(S): A total of 1,198 healthy, eumenorrheic women aged 18-40 years attempting spontaneous pregnancy with one to two prior pregnancy losses were included...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29385490/serum-and-plasma-metabolites-associated-with-postpartum-ovulation-and-pregnancy-risks-in-suckled-beef-cows-subjected-to-artificial-insemination
#15
S L Hill, K C Olson, J R Jaeger, J S Stevenson
Two experiments were conducted to determine relationships of blood metabolite concentrations, BW, BCS, and rump fat depth with postpartum ovulation and pregnancy risks, as well as their utility in predicting those outcomes in suckled beef cows. In experiment 1, plasma glucose collected 10 and 3 d before AI of suckled beef cows at seven locations did not differ between cows that had resumed estrous cycles (ovulated) before AI compared with anovulatory cows, whereas plasma glucose 3 d before AI was greater (P < 0...
February 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29376238/-features-of-professor-ma-kun-s-medication-in-treating-ovulatory-infertility
#16
Ya-Jing Tong, Hui-Xian Zhang, Yan-Xia Chen, Mei-Ling Dong, Kun Ma
In order to analyze Professor Ma Kun's medication in treating anovulatory infertility, her prescriptions for treating anovulatory infertility in 2012-2015 were collected. The medication features and the regularity of prescriptions were mined by using traditional Chinese medicine inheritance support system, association rules, complex system entropy clustering and other mining methods. Finally, a total of 684 prescriptions and 300 kinds of herbs were screened out, with a total frequency of 11 156 times; And 68 core combinations and 8 new prescriptions were mined...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29376236/-treatment-of-anovulatory-infertility-by-tonifying-kidney-and-promoting-blood-circulation
#17
Kun Ma, Ya-Jing Tong
Infertility is a common disease in women of childbearing age and is also a refractory disease. Anovulatory dysfunction is one of the main causes of female infertility, and the incidence of anovulatory infertility has been increasing year by year. Traditional Chinese medicine has unique advantages and definite curative effect on the treatment of this disease. Kidney deficiency is the basic pathogenesis and blood stasis is an important factor that has been through. Flexible of tonifying the kidney and promoting blood circulation treatment of anovulatory infertility in clinic, has achieved remarkable curative effect...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29376235/-study-on-the-mechanism-of-bushen-culuan-chongji-treating-kidney-deficiency-and-blood-stasis-in-ovulatory-dysfunctional-infertility
#18
Kun Ma, Min Li
Kidney deficiency and blood stasis is the main cause of ovulatory dysfunctional infertility. Kidney deficiency is the main pathological mechanism. Blood stasis is the main pathological manifestation, and it is an important factor throughout. Bushen Culuan Chongji is under the guidance of traditional Chinese medicine(TCM) theory, previous years of clinical experience, combined with the etiology and pathogenesis of anovulatory infertility and modern pharmacological research results, selected, not only maintains the TCM syndrome differentiation and different diseases features, but also reflects the superiority of the combination of disease...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29345163/low-dose-hp-hmg-in-an-antagonist-protocol-for-ivf-in-ovulatory-and-anovulatory-patients-with-high-amh
#19
Negjyp Sopa, Elisabeth Clare Larsen, Anders Nyboe Andersen
Women with high-AMH levels have an increased risk of ovarian hyperstimulation syndrome (OHSS). Studies have suggested that highly purified menotropin (HP-hMG) Menopur® reduces the risk. We, therefore, studied use of low-dose (112.5 IU/day) HP-hMG in ovulatory and anovulatory patients with high AMH (>32 pmol/L). The primary endpoint was the distribution of patients with appropriate, excessive, and inadequate response (5-14, ≥15, and ≤4 oocytes). Another endpoint was frequency of OHSS. Totally 115 women were included and 78 (67...
January 18, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29345030/reproductive-status-dependent-kisspeptin-and-rfamide-related-peptide-rfrp-gene-expression-in-female-damaraland-mole-rats
#20
Cornelia Voigt, Nigel C Bennett
Damaraland mole rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals, which exhibit high reproductive skew. Reproduction is monopolized by the dominant female of the group while subordinates are physiologically suppressed to the extent that they are anovulatory. It is thought that in these latter animals normal GnRH secretion from the hypothalamus is disrupted. The RFamide peptides kisspeptin (Kiss1) and RFamid-related peptide-3 (RFRP-3) are considered potent regulators of gonadotropin release...
January 18, 2018: Journal of Neuroendocrinology
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