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Major Depression,Suicide,Borderline Personality Disorder

Naoki Hayashi, Miyabi Igarashi, Atsushi Imai, Yuka Yoshizawa, Kaori Asamura, Yoichi Ishikawa, Taro Tokunaga, Kayo Ishimoto, Yoshitaka Tatebayashi, Hirohiko Harima, Naoki Kumagai, Hidetoki Ishii, Yuji Okazaki
BACKGROUND: Suicidal behavior (SB) is a major, worldwide health concern. To date there is limited understanding of the associated motivational aspects which accompany this self-initiated conduct. AIMS: To develop a method for identifying motivational features associated with SB by studying admitted psychiatric patients, and to examine their clinical relevance. METHODS: By performing a factor analytic study using data obtained from a patient sample exhibiting high suicidality and a variety of SB methods, Motivations for SB Scale (MSBS) was constructed to measure the features...
2017: PloS One
Judith McLenan, Carlo Lazzari, Gail McMillan, Robert Mackie
Objective: The aim of this study was to evaluate the type, severity and progression of psychiatric pathologies in a sample of 372 outpatients (age range 18-65 years) referred by their primary general practitioners (GPs) to an Urgent Referral Team (URT) based in a psychiatric hospital in Aberdeen, Scotland. This team offers immediate appointments (1- to 7-day delays) for rapid assessments and early interventions to the outpatients referred by their primary family doctors. Method: One-sample t-test and z statistic were used for data analysis...
October 2016: Iranian Journal of Psychiatry
Catherine Winsper, Nicole K Y Tang, Steven Marwaha, Suzet Tanya Lereya, Melanie Gibbs, Andrew Thompson, Swaran P Singh
AIM: To delineate the sleep profile of Borderline Personality Disorder (BPD). METHOD: A meta-analysis to synthesise findings on the objective and subjective sleep characteristics of BPD. RESULTS: We identified 32 studies published between 1980 and December 2015. Meta-analysis indicated significant differences between BPD and healthy control groups across objective sleep continuity (sleep onset latency, total sleep time, sleep efficiency) and architecture (rapid eye movement latency/density, slow wave sleep) measures, and self-reported sleep problems (nightmares, sleep quality)...
February 2017: Neuroscience and Biobehavioral Reviews
Richard C Friedman, Jennifer I Downey
In this issue of Psychodynamic Psychiatry, Michael Stone discusses therapeutic factors in the treatment of patients with Borderline Personality Disorder (BPD). He emphasizes the great diversity of borderline patients and points out that a number of manual-based therapies, each described by an acronym, generally achieve positive therapeutic results in the short term. Many borderline patients require years of psychotherapy, pharmacotherapy and additional treatments, however. Stone observes that patients with this disorder invariably have other personality characteristics and disorders...
2016: Psychodynamic Psychiatry
Leo Sher, Amanda M Fisher, Caitlin H Kelliher, Justin D Penner, Marianne Goodman, Harold W Koenigsberg, Antonia S New, Larry J Siever, Erin A Hazlett
Patients with borderline personality disorder (BPD) are at high risk for suicidal behavior. However, many BPD patients do not engage in suicidal behavior. In this study, we compared clinical features of BPD patients with or without a history of suicide attempts and healthy volunteers. Compared with healthy volunteers, both BPD groups had higher Affective Lability Scale (ALS), ALS - Depression-Anxiety Subscale, Barratt Impulsivity Scale (BIS), and Lifetime History of Aggression (LHA) scores and were more likely to have a history of temper tantrums...
December 30, 2016: Psychiatry Research
Mark Zimmerman, Carolina Guzman Holst, Heather L Clark, Matthew Multach, Emily Walsh, Lia K Rosenstein, Douglas Gazarian
BACKGROUND: Concerns about the generalizability of pharmacotherapy efficacy trials to "real-world" patients have been raised for more than 40 years. Almost all of this literature has focused on treatment studies of major depressive disorder (MDD). OBJECTIVE: The aim of the study was to review the psychiatric inclusion and exclusion criteria used in placebo-controlled trials that assessed the efficacy of medications for bipolar depression (bipolar disorder efficacy trials [BDETs]) and compare the criteria used in BDETs with those used in efficacy trials of antidepressants to treat MDD (antidepressant efficacy trials [AETs])...
August 19, 2016: CNS Drugs
Ismail M Youssef, Magda T Fahmy, Wafaa L Haggag, Khalid A Mohamed, Amany A Baalash
OBJECTIVE: To determine the frequency of suicidal thoughts and suicidal probability among poly-substance abusers in Saudi population, and to examine the relation between dual diagnosis and suicidal thoughts. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Al-Baha Psychiatric Hospital, Saudi Arabia, from May 2011 to June 2012. METHODOLOGY: Participants were 239 subjects, aged 18 - 45 years. We reviewed 122 individuals who fulfilled the DSM-IV-TR criteria of substance abuse for two or more substances, and their data were compared with that collected from 117 control persons...
February 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Robert P Fellows, Nayeli A Spahr, Desiree A Byrd, Monica Rivera Mindt, Susan Morgello
This study examined the association between trauma exposure, PTSD, suicide attempts, and other psychopathology among 316 racially/ethnically diverse HIV-infected men and women who underwent semi-structured psychiatric assessment. In addition, the role of psychological resilience in trauma exposure was examined in the context of neurological symptoms and functional status. Nearly half (47.8%; 151/316) of the participants reported trauma exposure, of which 47.0% (71/151) developed PTSD. Among trauma-exposed individuals, those with a current psychiatric diagnosis reported more neurological symptoms and lower functional status...
December 30, 2015: Psychiatry Research
Dina Popovic, Eduard Vieta, Jean-Michel Azorin, Jules Angst, Charles L Bowden, Sergey Mosolov, Allan H Young, Giulio Perugi
OBJECTIVES: The Bipolar Disorders: Improving Diagnosis, Guidance, and Education (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as suicidality. METHODS: A total of 2,811 subjects were enrolled in this multicenter cross-sectional study. Psychiatric symptoms, and sociodemographic and clinical variables were collected...
November 2015: Bipolar Disorders
G Perugi, J Angst, J-M Azorin, C L Bowden, A Caciagli, S Mosolov, E Vieta, A H Young
OBJECTIVE: The study focused on the relationship between mixed depression and borderline personality disorder (BPD). METHOD: The sample comprised 2811 patients with a major depressive episode (MDE). Clinical characteristics were compared in patients with (BPD+) and without (BPD-) comorbid BPD and in BPD+ with (MXS+) and without (MXS-) mixed features according to DSM-5 criteria. RESULTS: A total of 187 patients (6.7%) met the criteria for BPD...
June 12, 2015: Acta Psychiatrica Scandinavica
Simone Carradori, Romano Silvestri
Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline personality disorders, aggressiveness and violence in crime, obsessive-compulsive disorder, depression, suicide, schizophrenia, anorexia nervosa, migraine, dementia, and PD. Thus, MAO-B represents an attractive target for the treatment of a number of human diseases. The discovery, development, and therapeutic use of drugs that inhibit MAO-B are major challenges for future therapy...
September 10, 2015: Journal of Medicinal Chemistry
Giulio Perugi, Jules Angst, Jean-Michel Azorin, Charles L Bowden, Sergey Mosolov, Joao Reis, Eduard Vieta, Allan H Young
OBJECTIVE: To estimate the frequency of mixed states in patients diagnosed with major depressive episode (MDE) according to conceptually different definitions and to compare their clinical validity. METHOD: This multicenter, multinational cross-sectional Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-MIX study enrolled 2,811 adult patients experiencing an MDE. Data were collected per protocol on sociodemographic variables, current and past psychiatric symptoms, and clinical variables that are risk factors for bipolar disorder...
March 2015: Journal of Clinical Psychiatry
Nathan J Kolla, Lina Chiuccariello, Alan A Wilson, Sylvain Houle, Paul Links, R Michael Bagby, Shelley McMain, Charis Kellow, Jalpa Patel, Paraskevi V Rekkas, Suvercha Pasricha, Jeffrey H Meyer
BACKGROUND: Monoamine oxidase-A (MAO-A) is a treatment target in neurodegenerative illness and mood disorders that increases oxidative stress and predisposition toward apoptosis. Increased MAO-A levels in prefrontal cortex (PFC) and anterior cingulate cortex (ACC) occur in rodent models of depressive behavior and human studies of depressed moods. Extreme dysphoria is common in borderline personality disorder (BPD), especially when severe, and the molecular underpinnings of severe BPD are largely unknown...
January 15, 2016: Biological Psychiatry
Ruifan Zeng, Lisa J Cohen, Thachell Tanis, Azra Qizilbash, Yana Lopatyuk, Zimri S Yaseen, Igor Galynker
Suicidal behavior often accompanies both borderline personality disorder (BPD) and severe mood disorders, and comorbidity between the two appears to further increase suicide risk. The current study aims to quantify the risk of suicidality conferred by comorbid BPD diagnosis or features in three affective disorders: major depressive disorder (MDD), bipolar disorder (BP) and schizoaffective disorder. One hundred forty-nine (149) psychiatric inpatients were assessed by SCID I and II, and the Columbia Suicide Severity Rating Scale...
March 30, 2015: Psychiatry Research
Naoki Hayashi, Miyabi Igarashi, Atsushi Imai, Yuka Yoshizawa, Kaori Asamura, Yoichi Ishikawa, Taro Tokunaga, Kayo Ishimoto, Yoshitaka Tatebayashi, Naoki Kumagai, Hidetoki Ishii, Yuji Okazaki
AIMS: Suicidal behavior (SB) is a major mental health problem. The research has identified many factors related to SB, such as problems in the developmental period and psychiatric and personality disorders. However, the interrelation of these factors has not been clearly delineated. METHODS: The subjects were 155 patients consecutively admitted with SB to a psychiatric center in Tokyo. Structured interviews, including the Structured Clinical Interview for DSM-IV (SCID)-I and SCID-II, were conducted to determine characteristics of the SB-related factors...
September 2015: Psychiatry and Clinical Neurosciences
Christine Yuodelis-Flores, Richard K Ries
BACKGROUND: Addiction specialists frequently find themselves faced with suicidal behavior in their addictions patients. Although many addiction treatment programs will not accept clients with recent suicidal behavior, up to 40% of patients seeking treatment for substance dependence report a history of suicide attempt(s).(1-3) Risk factors for suicide have been studied in the general population and among people with mental illness, less is known about risk factors in those with substance use disorders and co-occurring disorders...
March 2015: American Journal on Addictions
Ehud Bodner, Sara Cohen-Fridel, Mordechai Mashiah, Michael Segal, Alexander Grinshpoon, Tzvi Fischel, Iulian Iancu
BACKGROUND: Negative attitudes towards patients with borderline personality disorder (BPD) may affect their treatment. We aimed to identify attitudes toward patients with BPD. METHODS: Clinicians in four psychiatric hospitals in Israel (n = 710; psychiatrists, psychologists, social workers and nurses) were approached and completed questionnaires on attitudes toward these patients. RESULTS: Nurses and psychiatrists reported encountering a higher number of patients with BPD during the last month, and exhibited more negative attitudes and less empathy toward these patients than the other two professions...
2015: BMC Psychiatry
Amy Silberschmidt, Susanne Lee, Mary Zanarini, S Charles Schulz
This study aims to extend previous research by considering gender differences in borderline personality (BPD) using both dimensional self-reported and clinical measures of symptomatology. Drawing from a cross-cultural, clinical trial sample, the authors compared female and male BPD subjects (N = 770; 211 male) between the ages of 18 and 65 using diagnostic and self-report data. The authors found that women with BPD have greater hostility and relationship disruption than men. Gender differences in eating disorders, particularly bulimia, are more divergent than in the general population...
December 2015: Journal of Personality Disorders
Germán L Teti, Federico Rebok, Leandro N Grendas, Demián Rodante, Agustina Fógola, Federico M Daray
BACKGROUND: Suicide is an issue of high public health impact. In Argentina there are few published studies on suicide and suicide attempt. OBJECTIVE: To determine the percentage of hospitalizations caused by suicidal attempt or suicidal ideation in a Mental Health Hospital of the City of Buenos Aires, describe the clinical and demographic characteristics of these patients and to analyze the frequency of adverse events at a 6-month follow-up. METHODS: In the present study, baseline and follow-up data of an analytical, observational, prospective cohort study are used...
May 2014: Vertex: Revista Argentina de Psiquiatriá
Frédéric N Brière, Paul Rohde, John R Seeley, Daniel Klein, Peter M Lewinsohn
BACKGROUND: Adolescent suicide attempts are disproportionally prevalent and frequently of low severity, raising questions regarding their long-term prognostic implications. In this study, we examined whether adolescent attempts were associated with impairments related to suicidality, psychopathology, and psychosocial functioning in adulthood (objective 1) and whether these impairments were better accounted for by concurrent adolescent confounders (objective 2). METHOD: Eight hundred and sixteen adolescents were assessed using interviews and questionnaires at four time points from adolescence to adulthood...
April 2015: Depression and Anxiety
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