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https://www.readbyqxmd.com/read/28818066/hepatoprotective-and-antioxidant-effects-of-single-clove-garlic-against-ccl4-induced-hepatic-damage-in-rabbits
#1
Khalid Mohammed Naji, Elham Shukri Al-Shaibani, Fatima A Alhadi, Safa'a Abdulrzaq Al-Soudi, Myrene R D'souza
BACKGROUND: The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl4-induced acute hepatotoxicity in male rabbits. METHODS: For this purpose, rabbits were orally administered with 3 ml of CCl4 /kg of body weight, followed by 0...
August 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28810533/deltamethrin-induced-oxidative-stress-in-kidney-and-brain-of-rats-protective-effect-of-artemisia-campestris-essential-oil
#2
Mongi Saoudi, Riadh Badraoui, Houda Bouhajja, Marwa Ncir, Fatma Rahmouni, Malek Grati, Kamel Jamoussi, Abdelfattah El Feki
Artemisia campestris (Asteraceae) is widely used in traditional medicine in Southern Tunisia as a decoction for its antivenom, anti-inflammatory, antirheumatic, and antimicrobial activities. A. campestris essential oil (ACEO) was obtained by hydrodistillation from the aerial parts, since it has beneficial and therapeutic effects. Deltamethrin is a synthetic pyrethroid with broad spectrum activities against acaricides and insects and widely used for veterinary and agricultural purposes. Exposure to deltamethrin leads to nephrotoxic and neurotoxic side effects for human and many species including birds and fish...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28808391/resolving-identification-issues-of-saraca-asoca-from-its-adulterant-and-commercial-samples-using-phytochemical-markers
#3
Satisha Hegde, Harsha Vasudev Hegde, Sunil Satyappa Jalalpure, Malleswara Rao Peram, Sandeep Ramachandra Pai, Subarna Roy
Saraca asoca (Roxb.) De Wilde (Ashoka) is a highly valued endangered medicinal tree species from Western Ghats of India. Besides treating cardiac and circulatory problems, S. asoca provides immense relief in gynecological disorders. Higher price and demand, in contrast to the smaller population size of the plant, have motivated adulteration with other plants such as Polyalthia longifolia (Sonnerat) Thwaites. The fundamental concerns in quality control of S. asoca arise due to its part of medicinal value (Bark) and the chemical composition...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28800865/contemporary-reviews-in-critical-care-medicine-anaphylaxis
#4
REVIEW
Daniel LoVerde, Onyinye I Iweala, Ariana Eginli, Guha Krishnaswamy
Anaphylaxis is a systemic, life threatening disorder triggered by mediators released by mast cells and basophils activated via allergic (IgE-mediated) or non-allergic (non-IgE-mediated) mechanisms. It is a rapidly evolving, multisystem process involving the integumentary, pulmonary, gastrointestinal and cardiovascular systems. Anaphylaxis and angioedema are serious disorders that can lead to fatal airway obstruction and culminate in cardiorespiratory arrest resulting in hypoxemia and/or shock. Often, these disorders can be appropriately managed in an outpatient setting...
August 8, 2017: Chest
https://www.readbyqxmd.com/read/28782613/the-regulation-of-inflammation-and-oxidative-status-against-lung-injury-of-residue-polysaccharides-by-lentinula-edodes
#5
Zhenzhen Ren, Juan Li, Xinling Song, Jianjun Zhang, Wenshuai Wang, Xiuxiu Wang, Zheng Gao, Huijuan Jing, Shangshang Li, Le Jia
In present study, two hydrolyzed residue polysaccharides (RPS) of enzymatic-RPS (ERPS) and acidic-RPS (ARPS) were successfully obtained from the residue of Lentinula edodes, and the anti-inflammatory as well as antioxidative effects on lipopolysaccharide-induced (LPS-induced) lung injured mice were investigated. The results demonstrated that ERPS showed superior lung protective effects by ameliorating the lung wet-to-dry weight (W/D) ratio, reducing the TNF-α, IL-6, and IL-1β levels in BALF, lowing the pulmonary MPO activity, decreasing the serum C3 and hs-CPR contents, as well as improving the antioxidant status by enhancing pulmonary enzyme activities (SOD, GSH-Px, CAT, and T-AOC) and eliminating the lipid peroxidation (MDA and LPO), respectively...
August 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28755576/hepatoprotective-effect-of-opuntia-microdasys-lehm-pfeiff-flowers-against-diabetes-type-ii-induced-in-rats
#6
Hassiba Chahdoura, Khawla Adouni, Aida Khlifi, Ichrak Dridi, Zohra Haouas, Fadoua Neffati, Guido Flamini, Habib Mosbah, Lotfi Achour
Opuntia sp. has long been used as a folk medicine to treat hepatitis and diabetes in Sicile (Italy). To extract the polyphenols from the flower of Opuntia microdasys Lehm. at post flowring stage and evaluate the antidiabetic activity in vitro and in vivo. The hepatoprotective activity of Opuntia microdasys aqueous flowers extract at post flowering stage (OFP) has been tested for their antidiabetic activity. On fructose-alloxan induced diabete in rat model, evaluating the inhibitory effects of OFP on some carbohydrate metabolizing enzymes, pancreatic α-amylase and intestinal α-glucosidase activities in vitro...
July 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28752930/oral-administration-of-grifola-frondosa-polysaccharides-improves-memory-impairment-in-aged-rats-via-antioxidant-action
#7
Zhaoxia Chen, Yanan Tang, Along Liu, Xiaobao Jin, Jiayong Zhu, Xuemei Lu
SCOPE: Grifola frondosa is an edible/medicinal mushroom with great nutritional value and bioactivity. The present study was performed to evaluate the beneficial effect of polysaccharides isolated from Grifola frondosa on memory impairment in aged rats. METHODS AND RESULTS: 20-month-old rats were gavaged with Grifola frondosa polysaccharides (GFP) for 8 weeks. Morris Water Maze test revealed that GFP administration significantly improved memory impairment in aged rats...
July 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28740608/gne-886-a-potent-and-selective-inhibitor-of-the-cat-eye-syndrome-chromosome-region-candidate-2-bromodomain-cecr2
#8
Terry D Crawford, James E Audia, Steve Bellon, Daniel J Burdick, Archana Bommi-Reddy, Alexandre Côté, Richard T Cummings, Martin Duplessis, E Megan Flynn, Michael Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, James R Kiefer, Jeremy Murray, Christopher G Nasveschuk, Arianne Neiss, Eneida Pardo, F Anthony Romero, Peter Sandy, Robert J Sims, Yong Tang, Alexander M Taylor, Vickie Tsui, Jian Wang, Shumei Wang, Yongyun Wang, Zhaowu Xu, Laura Zawadzke, Xiaoqin Zhu, Brian K Albrecht, Steven R Magnuson, Andrea G Cochran
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region candidate 2 (CECR2). Screening of our internal medicinal chemistry collection led to the identification of a pyrrolopyridone chemical lead, and subsequent structure-based drug design led to a potent and selective CECR2 bromodomain inhibitor (GNE-886) suitable for use as an in vitro tool compound...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28733105/adverse-reactions-of-%C3%AE-2-adrenoceptor-agonists-in-cats-reported-in-2003-2013-in-finland
#9
Marja R Raekallio, Marika Virtanen, Irmeli Happonen, Outi M Vainio
OBJECTIVE: To describe suspected adverse drug reactions in cats associated with use of α2-adrenoceptor agonists. STUDY DESIGN: Retrospective study. ANIMALS: A total of 90 cats. METHODS: Data were collected from reports on adverse reactions to veterinary medicines sent to the Finnish Medicines Agency during 2003-2013. All reports of suspected adverse reactions associated with use of α2-adrenoceptor agonists in cats were included...
March 1, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28705248/prevention-of-feline-leishmaniosis-with-an-imidacloprid-10-flumethrin-4-5-polymer-matrix-collar
#10
Emanuele Brianti, Luigi Falsone, Ettore Napoli, Gabriella Gaglio, Salvatore Giannetto, Maria Grazia Pennisi, Vito Priolo, Maria Stefania Latrofa, Viviana Domenica Tarallo, Fabrizio Solari Basano, Roberto Nazzari, Katrin Deuster, Matthias Pollmeier, Laura Gulotta, Vito Colella, Filipe Dantas-Torres, Gioia Capelli, Domenico Otranto
BACKGROUND: Leishmaniosis caused by Leishmania infantum is one of the most important vector-borne diseases affecting animals and humans worldwide. Dogs are considered main reservoirs of the zoonotic forms, though in the last years the role of cats as reservoirs has been increasingly investigated. Feline leishmaniosis (FeL) occurs in endemic areas and no specific preventive measures have been investigated so far. In this study the efficacy of a 10% imidacloprid/4.5% flumethrin polymer matrix collar, licensed for tick and flea prevention, has been assessed against FeL in a longitudinal study on 204 privately owned cats from the Aeolian islands (Sicily), an area highly endemic for the disease...
July 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28686977/cardioprotective-effect-of-the-xanthones-from-gentianella-acuta-against-myocardial-ischemia-reperfusion-injury-in-isolated-rat-heart
#11
Zhibin Wang, Gaosong Wu, Hua Liu, Na Xing, Yanping Sun, Yadong Zhai, Bingyou Yang, Ah-Ng Tony Kong, Haixue Kuang, Qiuhong Wang
Gentianella acuta (Michx.) Hulten is widely used for the treatment of arrhythmia and coronary heart disease in Ewenki Folk Medicinal Plants and Mongolian Medicine, popularly known as "Wenxincao" in China. To investigate the potential protective role of the xanthones from G. acuta against myocardial I/R injury in isolated rat heart and its possible related mechanism. The protective role of xanthones on myocardial I/R injury was studied on Langendorff apparatus. The hemodynamic parameters including the left ventricular developed pressure (LVDP), the maximum rate of up/down left intraventricular pressure (±dp/dtmax), coronary flow (CF) and heart rate (HR) were recorded during the perfusion...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28681939/vaccarin-administration-ameliorates-hypertension-and-cardiovascular-remodeling-in-renovascular-hypertensive-rats
#12
Xuexue Zhu, Zhou Zhou, Qingfeng Zhang, Weiwei Cai, Yuetao Zhou, Haijian Sun, Liying Qiu
Sympathetic overdrive, activation of renin angiotensin systems (RAS) and oxidative stress are vitally involved in the pathogenesis of hypertension and cardiovascular remodeling. We recently identified that vaccarin protected endothelial cell function from oxidative stress or high glucose. In this study, we aimed to investigate whether vaccarin attenuated hypertension and cardiovascular remodeling. Two-kidney one-clip (2K1C) model rats were used, and low dose of vaccarin (10 mg/kg), high dose of vaccarin (30 mg/kg), captopril (30 mg/kg) were intraperitoneally administrated...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28678404/characterization-of-companion-animal-pluripotent-stem-cells
#13
REVIEW
Y Z Paterson, C Kafarnik, D J Guest
Pluripotent stem cells have the capacity to grow indefinitely in culture and differentiate into derivatives of the three germ layers. These properties underpin their potential to be used in regenerative medicine. Originally derived from early embryos, pluripotent stem cells can now be derived by reprogramming an adult cell back to a pluripotent state. Companion animals such as horses, dogs, and cats suffer from many injuries and diseases for which regenerative medicine may offer new treatments. As many of the injuries and diseases are similar to conditions in humans the use of companion animals for the experimental and clinical testing of stem cell and regenerative medicine products would provide relevant animal models for the translation of therapies to the human field...
July 5, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28677741/mulberry-granules-protect-against-diabetic-cardiomyopathy-through-the-ampk-nrf2-pathway
#14
Yang Liu, Yan-Bo Zhao, Si-Wang Wang, Yu Zhou, Zhi-Shu Tang, Feng Li
Mulberry granules (MLD) is a traditional Chinese medicine prescription that has been used in the treatment of diabetes for many years. Recently, we found that MLD protected the heart from diabetes-associated cardiomyopathy when it was used to treat diabetes. However, the beneficial effects and possible mechanism remain unknown. To elucidate these effects, an experimental myocardial ischemia/reperfusion (MI/R) injury model in diabetes rats was used in this study. Male C57BL/6 mice were injected with streptozotocin to induce diabetes...
July 3, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28675320/flow-cytometry-for-feline-lymphoma-a-retrospective-study-regarding-pre-analytical-factors-possibly-affecting-the-quality-of-samples
#15
Valeria Martini, Serena Bernardi, Priscilla Marelli, Marzia Cozzi, Stefano Comazzi
Objectives Flow cytometry (FC) is becoming increasingly popular among veterinary oncologists for the diagnosis of lymphoma or leukaemia. It is accurate, fast and minimally invasive. Several studies on FC have been carried out in canine oncology and applied with great results, whereas there is limited knowledge and use of this technique in feline patients. This is mainly owing to the high prevalence of intra-abdominal lymphomas in this species and the associated difficulty in the diagnostic procedures needed to collect the sample...
July 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28669432/cardiorenal-syndrome-diagnosis-and-management
#16
REVIEW
João S Orvalho, Larry D Cowgill
Cardiorenal syndrome (CRS) has not been well characterized in veterinary medicine, yet an accurate appreciation of the kidney and the cardiovascular system and their interactions may have practical clinical implications. A consensus for cardiovascular-renal axis disorders of dogs and cats was recently attempted. The outcome of patients with CRS is likely to improve with the increasing awareness and ability to identify and understand the pathophysiologic characteristics of CRS. The utilization of existing and emerging organ-specific biomarkers with greater sensitivities than conventional diagnostics forecast new opportunities to diagnose and manage cardiac disease...
June 29, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28667412/exogenous-salicylic-acid-mediated-modulation-of-arsenic-stress-tolerance-with-enhanced-accumulation-of-secondary-metabolites-and-improved-size-of-glandular-trichomes-in-artemisia-annua-l
#17
Anjana Kumari, Neha Pandey, Shashi Pandey-Rai
The present study was undertaken to find out individual and interactive effects of arsenic (As) and salicylic acid (SA) on an important medicinal plant, Artemisia annua. As uptake and its accumulation was detected and found to be maximum in roots at higher As concentration (150 μM). Under As treatments, H2O2 and MDA content were induced. Biomass and chlorophyll content were negatively affected under As treatments. Furthermore, enzymatic (SOD, CAT, APX, and GR) and non-enzymatic antioxidants were also enhanced under As treatments...
June 30, 2017: Protoplasma
https://www.readbyqxmd.com/read/28662008/-evaluation-of-oxidative-reduction-markers-of-blood-in-patients-with-acute-coronary-syndromes-acs-subjected-to-cardiac-rehabilitation
#18
Anna Mejer-Barczewska, Joanna Kapusta, Małgorzata Godala, Edward Kowalczyk, Robert Irzmański, Jan Kowalski
Role in the pathogenesis of atherosclerosis play a reactive oxygen species. In the case of disturbance of dynamic balance between their production and antioxidant defense mechanisms comes to undesirable consequences - oxidative stress. Excessive exercise can, among others, disrupting the balance. AIM: The aim of the study was to evaluate the exponents of the processes of oxidation - reduction of blood in patients with ACS undergoing rehabilitation in a hospital setting. MATERIALS AND METHODS: The study included 25 patients after ACS STEMI, including 19 men and 6 women, aged 51...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28651233/terminalia-bellirica-gaertn-roxb-fruit-mitigates-ccl4-induced-oxidative-stress-and-hepatotoxicity-in-rats
#19
Jayesh Kuriakose, Helen Lal Raisa, Vysakh A, Binil Eldhose, Latha M S
Terminalia bellirica (Gaertn.) Roxb. is a medicinal plant used for the treatment of various ailments in the traditional system of medicine like Ayurveda where it has been prescribed as a rejuvenator and general health tonic. The fruit of the plant is one of the components of the age old ayurvedic formulation-'Triphala'. The present study evaluates curative effect of aqueous acetone extract of Terminalia bellirica fruits (AATB) against CCl4 induced oxidative stress and liver damage in an animal model. Two doses of the fruit extract (200mg/kg body weight and 400mg/kg body weight) were investigated for the beneficial effects...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28621602/resolution-of-nonurine-transudative-pleural-effusion-in-a-cat-after-removal-of-a-hydronephrotic-kidney
#20
Maura E Duffy, Andrew J Specht, Ahmira R Torres, May-Li Cuypers
CASE DESCRIPTION A 3-year-old spayed female Bengal cat was evaluated because of a history of bilateral pleural effusion and hydronephrosis of the right kidney. CLINICAL FINDINGS Cytologic analysis of a pleural fluid sample revealed characteristics of a pure transudate with a high percentage of lymphocytes. Results of fluid biochemical testing were not consistent with urine or chyle. Serum biochemical analysis and echocardiography yielded no evidence of hypoalbuminemia or high hydrostatic pressure secondary to cardiac disease...
July 1, 2017: Journal of the American Veterinary Medical Association
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