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https://www.readbyqxmd.com/read/28544934/preventive-effect-of-berberine-against-dmba-induced-breast-cancer-in-female-sprague-dawley-rats
#1
Kalyani Chowdary Karnam, Maheswara Ellutla, Lakshmi Narendra Bodduluru, Eshvendar Reddy Kasala, Shravan Kumar Uppulapu, Malayamarutham Kalyankumarraju, Mangala Lahkar
Breast cancer is the prime cause for cancer mortality in women worldwide. The importance of diverse natural and dietary agents to reduce the risk of developing breast cancer is well established. Berberine, a natural isoquinoline alkaloid found in many medicinal plants is widely used in traditional Indian and Chinese medicine. Because of its capability to seize the cell cycle and induce apoptosis of numerous malignant cells, berberine has received considerable attention as a potential anticancer agent. In the present study, breast cancer was induced in Sprague Dawley (SD) rats by intragastric administration of 7, 12-dimethylbenz[a]anthracene (DMBA) at a dose of 80mg/kg of body weight...
May 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28539739/effects-of-ligusticum-porteri-osha-root-extract-on-human-promyelocytic-leukemia-cells
#2
Khanh Nguyen, Jean Sparks, Felix Omoruyi
BACKGROUND: Ligusticum porteri roots have been traditionally used in folk medicine, but the scientific basis is unclear. OBJECTIVE: To investigate the cytotoxicity, antioxidant, and immunomodulatory effects of L. porteri root extract on human promyelocytic leukemia (HL-60) cells and H2O2-induced oxidative damaged HL-60 cells. MATERIALS AND METHODS: HL-60 cells were incubated with different concentrations of root extract, and cells were harvested for viability assays on day 3 and 7...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28534982/pre%C3%A2-treatment-with-chrysanthemum%C3%A2-indicum-linn%C3%A3-extract-protects-pyramidal-neurons-from-transient-cerebral-ischemia-via-increasing-antioxidants-in-the-gerbil-hippocampal-ca1-region
#3
In Hye Kim, Tae-Kyeong Lee, Jeong Hwi Cho, Jae-Chul Lee, Joon Ha Park, Ji Hyeon Ahn, Bich-Na Shin, Bai Hui Chen, Hyun-Jin Tae, Yang Hee Kim, Jong-Dai Kim, Young-Myeong Kim, Moo-Ho Won, Il Jun Kang
Chrysanthemum indicum Linné extract (CIL) is used in herbal medicine in East Asia. In the present study, gerbils were orally pre‑treated with CIL, and changes of antioxidant enzymes including superoxide dismutase (SOD) 1 and SOD2, catalase (CAT) and glutathione peroxidase (GPX) in the hippocampal CA1 region following 5 min of transient cerebral ischemia were investigated and the neuroprotective effect of CIL in the ischemic CA1 region was examined. SOD1, SOD2, CAT and GPX immunoreactivities were observed in the pyramidal cells of the CA1 region and their immunoreactivities were gradually decreased following ischemia‑reperfusion and barely detectable at 5 days post‑ischemia...
May 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28529177/senecio-brasiliensis-impairs-eclosion-rate-and-induces-apoptotic-cell-death-in-larvae-of-drosophila-melanogaster
#4
Giulianna Echeverria Macedo, Karen Kich Gomes, Nathane Rosa Rodrigues, Illana Kemmerich Martins, Gabriel da Luz Wallau, Nélson Rodrigues de Carvalho, Litiele Cezar da Cruz, Dennis Guilherme da Costa Silva, Aline Augusti Boligon, Jeferson Luis Franco, Thaís Posser
Senecio brasilienis (Spreng) Less., is a species native from Brazil, popularly known as "maria mole", and known to induce hepatotoxicity due to its high content of Pyrrolizidine alkaloids. Despite its toxicity, this plant is widely used in Brazilian folk medicine. Considering the antagonizing effects described for S. brasiliensis, we describe here molecular markers involved in the toxicity of hydroalcoholic extract from leaves of S. brasiliensis (HESB) in Drosophila melanogaster. Phytochemical analysis of HESB revealed the presence of phenolic acids and flavonoids...
May 18, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28501008/ethanol-extract-and-its-dichloromethane-fraction-of-alpinia-oxyphylla-miquel-exhibited-hepatoprotective-effects-against-ccl4-induced-oxidative-damage-in-vitro-and-in-vivo-with-the-involvement-of-nrf2
#5
Qiao Zhang, Xiaolong Hu, Fuhai Hui, Qi Song, Can Cui, Changli Wang, Qingchun Zhao
Alpinia oxyphylla Miq. (A. oxyphylla), as a kind of medicine which also be used as food, is widely used in East Asian for the treatment of dyspepsia, diarrhea, abdominal pain and deficiency cold of spleen and stomach. This study aimed to investigate the protective effects of ethanol extract (EE) and its dichloromethane fraction (DM) of A. oxyphylla, which are rich in phenolic compounds, against CCl4-induced hepatic injury in vitro and in vivo. EE, DM and silymarin ameliorated CCl4-induced decrease of cell viability and increase of reactive oxygen species (ROS) in HepG2 cells...
May 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28491442/respiratory-distress-associated-with-lungworm-infection-in-a-kitten
#6
Melissa M Hawley, Lynelle R Johnson, Donato Traversa, Dan Bucy, Karen M Vernau, William Vernau
CASE SUMMARY: A 5-month-old feral kitten developed worsening respiratory signs, including tachypnea, coughing and wheezing after standard anthelmintic treatment with fenbendazole at a local shelter. The kitten was referred to the University of California, Davis, William R Pritchard Veterinary Medicine Teaching Hospital for further evaluation. Thoracic radiographs revealed a severe diffuse bronchointerstitial pattern with bronchial cuffing, ill-defined nodules and lymphadenomegaly. Differentials included infectious etiologies such as toxoplasmosis, feline infectious peritonitis and cryptococcosis...
July 2016: JFMS Open Rep
https://www.readbyqxmd.com/read/28491437/hypersensitivity-reaction-associated-with-subcutaneous-glargine-insulin-therapy-in-a-cat
#7
Lisa A Murphy, Greg F Zuendt, Reid K Nakamura, Paul Gambardella
CASE SUMMARY: A 14-year-old, domestic shorthair cat was treated for transient diabetes mellitus for 3 months with glargine insulin, which was discontinued when the diabetes mellitus resolved. Approximately 36 months later the diabetes mellitus recurred and glargine insulin was restarted. Within 2-3 mins of the first injection the cat collapsed, developed profuse vomiting and diarrhea, as well as facial swelling and diffuse erythema. A hypersensitivity reaction was suspected and the cat was treated with antihistamines, aggressive fluid therapy and gastrointestinal support...
July 2016: JFMS Open Rep
https://www.readbyqxmd.com/read/28484857/muscle-architectural-properties-in-the-common-marmoset-callithrix-jacchus
#8
Naomichi Ogihara, Motoharu Oishi, Ryogo Kanai, Hikaru Shimada, Takahiro Kondo, Kimika Yoshino-Saito, Junichi Ushiba, Hideyuki Okano
The common marmoset, Callithrix jacchus, is a small New World monkey that has recently gained attention as an important experimental animal model in the field of neuroscience as well in rehabilitative and regenerative medicine. This attention reflects the closer phylogenetic relationship between humans and common marmosets compared to that between humans and other experimental animals. When studying the neuronal mechanism behind various types of neurological motor disorders using the common marmoset, possible differences in muscle parameters (e...
May 8, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28476175/biochemical-and-proteomics-analyses-of-antioxidant-enzymes-reveal-the-potential-stress-tolerance-in-rhododendron-chrysanthum-pall
#9
Xiaofu Zhou, Silin Chen, Hui Wu, Yi Yang, Hongwei Xu
BACKGROUND: Rhododendron chrysanthum Pall., an endangered species with significant ornamental and medicinal value, is endemic to the Changbai Mountain of China and can also serve as a significant plant resource for investigating the stress tolerance in plants. Proteomics is an effective analytical tool that provides significant information about plant metabolism and gene expression. However, no proteomics data have been reported for R. chrysanthum previously. In alpine tundra, the abiotic stress will lead to a severe over-accumulation of reactive oxygen species (ROS)...
May 3, 2017: Biology Direct
https://www.readbyqxmd.com/read/28475267/sublethal-effects-of-the-pyrethroid-insecticide-deltamethrin-on-oxidative-stress-parameters-in-green-toad-bufotes-viridis-l
#10
Tijana B Radovanović, Mohammed Nasia, Imre I Krizmanić, Marko D Prokić, Jelena P Gavrić, Svetlana G Despotović, Branka R Gavrilović, Slavica S Borković-Mitić, Slađan Z Pavlović, Zorica S Saičić
Pyrethroids are synthetic insecticides widely used in agriculture, public health and veterinary medicine. Deltamethrin, a type II of pyrethroid insecticide, has attracted particular attention because of its frequent use. The mechanisms of the toxicity of most pesticides, including pyrethroids, in nontarget organisms is linked to the production of free radicals, oxidative stress induction, increased lipid peroxidation (LPO) and disruption of the total antioxidant potential. The aim of present study was to investigate the effects of acute toxicity of three different concentrations (8 mg/kg body weight (bw), 16 mg/kg bw and 32 mg/kg bw) of orally applied deltamethrin after 96 hours of treatment...
May 5, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28472605/total-flavonoid-extract-from-abelmoschus-manihot-l-medic-flowers-attenuates-d-galactose-induced-oxidative-stress-in-mouse-liver-through-the-nrf2-pathway
#11
Yan Qiu, Peng-Fei Ai, Jian-Jun Song, Chang Liu, Zhi-Wei Li
Abelmoschus manihot (L.) Medic is an edible hibiscus that is rich in flavonoids, and its use as Chinese herbal medicine for the treatment of diseases and health maintenance dates back to ancient times. The chemical compositions of total flavonoid of A. manihot (L.) Medic flower extract (TFAE) were identified and determined by high performance liquid chromatography (HPLC). The effects of TFAE on antioxidative activities in a d-galactose (d-gal)-induced mouse model and Nrf2-mediated antioxidant responses were evaluated...
May 4, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28460795/obesity-and-associated-comorbidities-in-people-and-companion-animals-a-one-health-perspective
#12
REVIEW
M Chandler, S Cunningham, E M Lund, C Khanna, R Naramore, A Patel, M J Day
This article reviews the biology, prevalence and risks for obesity in people and companion dogs and cats, and explores the links between obesity and diabetes mellitus and cancer across these species. Obesity is a major healthcare problem in both human and veterinary medicine and there is an increasing prevalence of obesity in people and pets. In people and animals, obesity is a complex disorder involving diet, level of physical activity, behavioural factors, socioeconomic factors, environment exposures, genetics, metabolism and the microbiome...
April 28, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28445615/status-epilepticus-in-dogs-and-cats-part-1-etiopathogenesis-epidemiology-and-diagnosis
#13
Susan Blades Golubovic, John H Rossmeisl
OBJECTIVE: To review current knowledge of the etiopathogenesis, diagnosis, and consequences of status epilepticus (SE) in veterinary patients. DATA SOURCES: Human and veterinary literature, including clinical and laboratory research and reviews. ETIOPATHOGENESIS: Status epilepticus is a common emergency in dogs and cats, and may be the first manifestation of a seizure disorder. It results from the failure of termination of an isolated seizure...
May 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28439463/molecular-assessment-of-the-fecal-microbiota-in-healthy-cats-and-dogs-before-and-during-supplementation-with-fructo-oligosaccharides-fos-and-inulin-using-high-throughput-454-pyrosequencing
#14
Jose F Garcia-Mazcorro, Jose R Barcenas-Walls, Jan S Suchodolski, Jörg M Steiner
Prebiotics are selectively fermentable dietary compounds that result in changes in the composition and/or activity of the intestinal microbiota, thus conferring benefits upon host health. In veterinary medicine, commercially available products containing prebiotics have not been well studied with regard to the changes they trigger on the composition of the gut microbiota. This study evaluated the effect of a commercially available nutraceutical containing fructo-oligosaccharides (FOS) and inulin on the fecal microbiota of healthy cats and dogs when administered for 16 days...
2017: PeerJ
https://www.readbyqxmd.com/read/28395430/-changes-of-adherens-junctions-between-the-epithelial-cells-of-intestinal-mucosal-barrier-in-irritable-bowel-syndrome
#15
C Y Chen, M Zhang, S S Wang, B Lü, X Wang
Objective: To investigate whether there are changes in adherens junctions(AJ), including E-cadherin (E-cad) and β-catenin (β-cat), in the colonic mucosa of irritable bowel syndrome (IBS). Methods: Colorectal dilatation combined with restraint stress was used to establish IBS SD rat model. There were 8 rats in the model group and 8 rats in normal control group. From each rat, the colon tissue 5 centimeters away from ileocecum (I) and the junction of the rectum and sigmoid colon (R) were taken, in which E-cad and β-cat mRNA, protein level and structural changes were detected using real-time quantitative-PCR, Western blot, and immunofluorescence...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28368327/ugonin-m-a-helminthostachys-zeylanica-constituent-prevents-lps-induced-acute-lung-injury-through-tlr4-mediated-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#16
Kun-Chang Wu, Shyh-Shyun Huang, Yueh-Hsiung Kuo, Yu-Ling Ho, Chang-Syun Yang, Yuan-Shiun Chang, Guan-Jhong Huang
Helminthostachys zeylanica (L.) Hook. is plant that has been used in traditional Chinese medicine for centuries for the treatment of inflammation, fever, pneumonia, and various disorders. The aims of the present study are to figure out the possible effectiveness of the component Ugonin M, a unique flavonoid isolated from H. zeylanica, and to elucidate the mechanism(s) by which it works in the LPS-induced ALI model. In this study, Ugonin M not only inhibited the production of pro-inflammatory mediators such as NO, TNF-α, IL-1β, and IL-6, as well as infiltrated cellular counts and protein content in the bronchoalveolar lavage fluid (BALF) of lipopolysaccharides (LPS)-induced acute lung injury (ALI) mice, but also ameliorated the severity of pulmonary edemas through the score of a histological examination and the ratio of wet to dry weight of lung...
April 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28367722/feline-urine-metabolomic-signature-characterization-of-low-molecular-weight-substances-in-urine-from-domestic-cats
#17
Sol-Maiam Rivera-Vélez, Nicolas F Villarino
Objectives This aim of this study was to characterize the composition and content of the feline urine metabolome. Methods Eight healthy domestic cats were acclimated at least 10 days before starting the study. Urine samples (~2 ml) were collected by ultrasound-guided cystocentesis. Samples were centrifuged at 1000 × g for 8 mins, and the supernatant was analyzed by gas chromatography/time-of-flight mass spectrometery. The urine metabolome was characterized using an untargeted metabolomics approach. Results Three hundred and eighteen metabolites were detected in the urine of the eight cats...
March 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28363525/protective-effect-of-a-phenolic-extract-containing-indoline-amides-from-portulaca-oleracea-against-cognitive-impairment-in-senescent-mice-induced-by-large-dose-of-d-galactose-nano2
#18
Peipei Wang, Hongxiang Sun, Dianyu Liu, Zezhao Jiao, Su Yue, Xiuquan He, Wen Xia, Jianbo Ji, Lan Xiang
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea L. is a potherb and also a widely used traditional Chinese medicine. In accordance with its nickname "longevity vegetable", pharmacological study demonstrated that this plant possessed antioxidant, anti-aging, and cognition-improvement function. Active principles pertaining to these functions of P. oleracea need to be elucidated. AIM OF THE STUDY: The present study evaluated the effect of a phenolic extract (PAAs) from P...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28345991/correlation-between-serum-homocysteine-concentration-and-severity-of-mitral-valve-disease-in-dogs
#19
Chang-Min Lee, Da-Min Jeong, Min-Hee Kang, Seung-Gon Kim, Jae-Ik Han, Hee-Myung Park
OBJECTIVE To measure serum homocysteine concentrations in dogs with myxomatous mitral valve disease (MMVD) and identify any association between this variable and stage of MMVD. ANIMALS 53 client-owned dogs with MMVD and 10 healthy control Beagles. PROCEDURES Dogs with MMVD were allocated to 3 groups in accordance with the staging system for chronic valvular heart disease in dogs and cats of the American College of Veterinary Internal Medicine. Blood samples were collected from all dogs, and serum homocysteine and cardiac troponin 1 concentrations were measured by enzyme immunoassay and chemiluminescence immunoassay, respectively...
April 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28339384/evaluation-of-the-most-frequently-prescribed-extemporaneously-compounded-veterinary-medications-at-a-large-independent-community-pharmacy
#20
Adel H Karara, Ryan Hines, Zehra Demir, Bethran Nnorom, Robert Horsey, Geoffrey Twigg
Extemporaneous drug formulation is essential to provide optimal pharmaceutical care to veterinary patients. The need for this is exacerbated by the fact that commercially produced veterinary-specific products, without a human indication, require specialty veterinary manufacturing facilities and a new animal drug application process to gain marketing approval. This study examined the prescription patterns of extemporaneously compounded veterinary preparations in the compounding department at a large independent community pharmacy...
November 2016: International Journal of Pharmaceutical Compounding
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