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https://www.readbyqxmd.com/read/28287017/oxidative-stress-and-gsts-genetic-polymorphisms-in-medical-staff-professionally-exposed-to-ionizing-radiation
#1
Hajer Doukali, Ghada Ben Salah, Latifa Hamdaoui, Mounira Hajjaji, Mouna Tabebi, Leila Ammar-Keskes, Mohamed-Elarbi Masmoudi, Hassen Kamoun
PURPOSE: Ionizing radiation (IR) is considered as a diagnostic and therapeutic tool in medicine. However, chronic occupational exposure of medical staff to IR may affect the antioxidant status and, as result, DNA damage and cancers as well. The objective of our study was to evaluate the oxidative stress profile caused by IR in 29 Tunisian medical staff from radiology and radiotherapy departments, and to find an association between the GSTM1null, GSTT1null, and GSTP1 Ile105Val polymorphisms and oxidative stress biomarkers...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28264680/rhein-exhibits-antioxidative-effects-similar-to-rhubarb-in-a-rat-model-of-traumatic-brain-injury
#2
Xia Xu, Huiying Lv, Zian Xia, Rong Fan, Chunhu Zhang, Yang Wang, Dongsheng Wang
BACKGROUND: The brain is secondarily harmed by pathological, physiological, and biological reactions that are caused by traumatic brain injury (TBI). Rhein, a significant composition of Rhubarb, is a well-known traditional Chinese treatment method and has a strong oxidation-resisting characteristic, but Rhein's mechanism remains unclear. METHODS: This study aimed to identify Rhein in the brain tissues of TBI model of rats, and confirm whether Rhein induced an antioxidative effect similar to its parent medicine, Rhubarb...
March 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28261616/the-protective-effect-of-chrysanthemum-indicum-extract-against-ankylosing-spondylitis-in-mouse-models
#3
Mei Dong, Dongsheng Yu, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi
In traditional Chinese and Korean homeopathic medicine, Chrysanthemum indicum Linné (Asteraceae) is a time-honored herb, prescribed for the resolution of symptoms associated with inflammatory and hypertensive conditions as well as those affecting the lungs and its associated structures. The goal of this work is to investigate the defensive role of Chrysanthemum indicum extract in fighting ankylosing spondylitis (AS) using mouse models, through which the manifestation and extent of the disease progression were measured with quantitative analysis of the intervertebral joints...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28250318/characterization-of-species-differences-in-xenobiotic-metabolism-in-non-experimental-animals
#4
Hazuki Mizukawa, Yoshinori Ikenaka, Mayu Kakehi, Shouta Nakayama, Mayumi Ishizuka
 The ability to metabolize xenobiotics in organisms has a wide degree of variation among organisms. This is caused by differences in the pattern of xenobiotic bioaccumulation among organisms, which affects their tolerance. It has been reported in the veterinary field that glucuronidation (UGT) activity in cats, acetylation activity in dogs and sulfation (SULT) activity in pigs are sub-vital in these species, respectively, and require close attention when prescribing the medicine. On the other hand, information about species differences in xenobiotics metabolism remains insufficient, especially in non-experimental animals...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28245741/isfm-consensus-guidelines-on-the-diagnosis-and-management-of-hypertension-in-cats
#5
Samantha S Taylor, Andrew H Sparkes, Katherine Briscoe, Jenny Carter, Salva Cervantes Sala, Rosanne E Jepson, Brice S Reynolds, Brian A Scansen
Practical relevance: Feline hypertension is a common disease in older cats that is frequently diagnosed in association with other diseases such as chronic kidney disease and hyperthyroidism (so-called secondary hypertension), although some cases of apparent primary hypertension are also reported. The clinical consequences of hypertension can be severe, related to 'target organ damage' (eye, heart and vasculature, brain and kidneys), and early diagnosis followed by appropriate therapeutic management should help reduce the morbidity associated with this condition...
March 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28240954/effect-of-cold-storage-on-immediate-graft-function-in-an-experimental-model-of-renal-transplantation-in-cats
#6
Rebecca A Csomos, Robert J Hardie, Chad W Schmiedt, Fern A Delaney, Jonathan F McAnulty
OBJECTIVE To assess the effect of cold storage (CS) on immediate posttransplantation function of renal autografts in cats. ANIMALS 15 healthy 1-year-old cats. PROCEDURES Cats were assigned to 2 groups and underwent autotransplantation of the left kidney followed by nephrectomy of the right kidney. The left kidney was autotransplanted either immediately (IT group; n = 6) or after being flushed with a cold sucrose phosphate solution and stored on ice while the implant site was prepared (CS group; 9). Serum creatinine and BUN concentrations were monitored daily and autografts were ultrasonographically examined intermittently for 14 days after surgery...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28237915/hepatoprotective-activity-of-butea-monosperma-bark-against-thioacetamide-induced-liver-injury-in-rats
#7
Varinder Kaur, Manish Kumar, Paramjeet Kaur, Sandeep Kaur, Amrit Pal Singh, Satwinderjeet Kaur
For thousands of years, the plant-based natural products have been a source of curative agents for various ailments. Butea monosperma (Fabaceae) has an important place in Indian traditional system of medicine for curing number of disorders. The present study deals with evaluation of hepatoprotective properties of ethyl acetate fraction (Beac) from B. monosperma bark in rat model. In preliminary antioxidant studies, Beac demonstrated pronounced superoxide scavenging (IC50 88.85μg/ml) and anti-lipid peroxidation (IC50 131...
February 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28235928/is-treating-anal-furunculosis-with-5%C3%A2-mg-kg-ciclosporin-once-daily-the-optimal-dosing-schedule
#8
Cherry Phypers, Kristen Reyher, Emma Place, Natalie Barnard, Aiden Foster
Critically Appraised Topics (CATs) are a standardised, succinct summary of research evidence organised around a clinical question, and a form of evidence synthesis used in the practice of evidence-based medicine (EBM) and evidence-based veterinary medicine (EBVM). Access to CATs enables clinicians to incorporate evidence from the scientific literature into clinical practice and they have been used to teach EBVM at the University of Bristol's School of Veterinary Sciences since 2011. CATs from Bristol university will be regularly published in the Clinical Decision Making section of Veterinary Record...
February 25, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28235786/systematic-account-of-animal-poisonings-in-germany-2012-2015
#9
S E McFarland, R H Mischke, C Hopster-Iversen, X von Krueger, H Ammer, H Potschka, A Stürer, K Begemann, H Desel, M Greiner
A systematic retrospective study on animal poisonings in Germany (wildlife excluded) between January 2012 and December 2015 was conducted. Data were collected on animal exposure calls to German poison centres, poisoning cases presenting to the University of Veterinary Medicine, Hannover Small Animal and Equine Clinics, cases involving off-label use of veterinary medicinal products reported to the Federal Office of Consumer Protection and Food Safety and toxicological submissions to the Institute of Pharmacology, Toxicology, and Pharmacy, Faculty of Veterinary Medicine, Ludwig-Maximilians-University, Munich...
February 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28213107/hypoglycemic-effect-of-the-polyphenols-rich-extract-from-rose-rugosa-thunb-on-high-fat-diet-and-stz-induced-diabetic-rats
#10
Liu Liu, Dan Tang, Haiqing Zhao, Xuelei Xin, Haji Akber Aisa
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa rugosa Thunb is a traditional Uygur medicine that has been used in the treatment of diabetes in Uygur ancient recipe for hundreds of years. However, the mechanism of Rosa rugosa Thunb activity is still unclear. This study was designed to address this issue by studying the polyphenols enriched extract (RPE) of Rosa rugosa Thunb in diabetic rats. MATERIALS AND METHODS: RPE were tested in the inhibition of α-glucosidase and oxidative stress in vitro...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28185306/antimicrobial-use-guidelines-for-treatment-of-respiratory-tract-disease-in-dogs-and-cats-antimicrobial-guidelines-working-group-of-the-international-society-for-companion-animal-infectious-diseases
#11
M R Lappin, J Blondeau, D Boothe, E B Breitschwerdt, L Guardabassi, D H Lloyd, M G Papich, S C Rankin, J E Sykes, J Turnidge, J S Weese
Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, the International Society for Companion Animal Infectious Diseases convened a Working Group of clinical microbiologists, pharmacologists, and internists to share experiences, examine scientific data, review clinical trials, and develop these guidelines to assist veterinarians in making antimicrobial treatment choices for use in the management of bacterial respiratory diseases in dogs and cats...
February 10, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28183234/therapeutic-and-fertility-restoration-effects-of-ionidium-suffruticosum-on-sub-fertile-male-albino-wistar-rats-effects-on-testis-and-caudal-spermatozoa
#12
Kuppusamy Chenniappan, Kadarkari Murugan
CONTEXT: Ionidium suffruticosum (L.) Ging (Violaceae) is an important medicinal plant widely used as a herbal traditional medicine in Ayurveda for the treatment of infertility. Currently, little pharmacological information is available on its male fertility properties following prolonged use. OBJECTIVE: To investigate I. suffruticosum leaf extracts for male fertility parameters. MATERIALS AND METHODS: The ethanol lyophilized fraction was administered orally on carbendazim-induced sub-fertility rats (250 mg/kg body weight for 28 days)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28167451/immunoprotective-activity-and-antioxidant-properties-of-cactus-opuntia-ficus-indica-extract-against-chlorpyrifos-toxicity-in-rats
#13
Amani Smida, Saida Ncibi, Jihen Taleb, Anouar Ben Saad, Sana Ncib, Lazhar Zourgui
Opuntia ficus indica (family Cactaceae) is a typical Mediterranean plant, mainly used in food and traditional folk medicine. The present study was designed to evaluate the protective effect of Opuntia ficus indica extract against chlorpyrifos (CPF)-induced immunotoxicity in rats. The experimental animals consisted of four groups of Wistar rats (5-6 weeks old) of eight each: a control group, a group treated with CPF (10mg/kg), a group treated with Opuntia ficus indica extract (100mg/kg), and a group treated with cactus extract then treated with CPF...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28166421/vitamin-e-and-selenium-treatment-of-monocrotaline-induced-hepatotoxicity-in-rats
#14
G Cuce, H T Canbaz, M E Sozen, F H Yerlikaya, S Kalkan
Monocrotaline (MCT) is a hepatotoxic pyrrolizidine alkaloid that is derived from plants; exposure may occur by consumption of contaminated grains, herbal teas and medicines. MCT can cause liver damage. We investigated the antioxidant effects of selenium (Se) and vitamin E against the toxic effects of MCT. Female Wistar albino rats were divided into four groups: a control group, an MCT group, an MCT + Se group, and an MCT + vitamin E group. Liver tissues were harvested, fixed, processed to paraffin and sections were cut...
February 6, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28164402/allergen-specific-immunotherapy-prescription-patterns-in-veterinary-practice-a-us-population-based-cohort-study
#15
Kathy Chu Tater, William Elliott Cole, Paul David Pion
BACKGROUND: Poor adherence to continuing allergen-specific immunotherapy treatment (ASIT) may be an issue in veterinary medicine. No studies describe how allergen tests are used in general veterinary practice, including the percentage of patients that receive ASIT after allergen testing. HYPOTHESIS/OBJECTIVES: Assess veterinary ASIT patterns in United States general practices. ANIMALS: Dogs (n = 2,557) and 121 cats allergen-tested at 177 hospitals (173 general practice and four specialty practices) in 44 states...
February 5, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28160310/acute-phase-proteins-response-in-cats-naturally-infected-with-hepatozoon-felis-and-babesia-vogeli
#16
Hugo Vilhena, Asta Tvarijonaviciute, José J Cerón, Lisete Vieira, Josep Pastor, Ana C Silvestre-Ferreira
BACKGROUND: The measurement of acute phase proteins (APP) is being increasingly used in human and veterinary medicine in diagnosis, prognosis, treatment monitoring, and in general health screening. However, information about the APP response in cats infected with agents of vector-borne diseases is lacking. OBJECTIVES: The purpose of the study was to investigate the concentrations of serum amyloid A (SAA), haptoglobin (Hp), and paraoxonase-1 (PON1) in cats naturally infected with Hepatozoon felis and Babesia vogeli...
February 3, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28152725/implementing-psychosocial-distress-screening-across-a-health-system-herding-cats-or-herding-cats
#17
(no author information available yet)
113 Background: With the American College of Surgeons Commission on Cancer 2015 Standards in hand, Penn Medicine embarked on a project to formulate an entity-wide plan for the provision of psychosocial distress screening. Identifying psychosocial distress and providing resources to meet those needs is an essential component of quality cancer care. Penn Medicine and the Abramson Cancer Center provided more than 91,000 chemotherapy treatments, 121,000 radiation treatments, and 14,000 proton therapy treatments in FY 15 in urban, suburban and rural settings with wide variations in resources...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152474/hepatoprotective-role-of-ricinus-communis-leaf-extract-against-d-galactosamine-induced-acute-hepatitis-in-albino-rats
#18
Pappithi Ramesh Babu, Cherukupalle Bhuvaneswar, Gandham Sandeep, Chintha Venkata Ramaiah, Wudayagiri Rajendra
Ricinus communis (RC) is a traditional medicinal plant which has been used by Chenchu and Yerukula tribes for treating their liver ailments. The present work is aimed to explore the hepatoprotective efficacy of Ricinus communis against d-galactosamine (D-GalN) induced hepatitis rat model and its therapeutic potential compared with standard drug, silymarin (100mg/kg.bw). In vitro antioxidant activity of Methanolic extract of Ricinus communis leaves (MERCL) was assayed through DPPH and H2O2 free radical scavenging activity...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28142381/questions-and-challenges-in-the-development-of-mesenchymal-stromal-stem-cell-based-therapies-in-veterinary-medicine
#19
Lax Devireddy, Lynne Boxer, Michael Myers, Mark Skasko, Rudell Screven
he therapeutic potential of stem cells has fascinated those interested in treating diseases in both human and animal subjects. Although the exact mechanism of action and the definitive effectiveness of stem cell therapies remain unclear, animal owner perceptions and a desire for improved treatment options have fueled the interest of clinicians and stakeholders. Standards do not yet exist to define the critical attributes of mesenchymal stem cell (MSC)-based products derived from veterinary species such as the dog, cat, and horse...
January 31, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28142229/whole-genome-dna-methylation-analyses-revealed-epigenetic-instability-in-tumorigenic-human-ips-cell-derived-neural-stem-progenitor-cells
#20
Tsuyoshi Iida, Akio Iwanami, Tsukasa Sanosaka, Jun Kohyama, Hiroyuki Miyoshi, Narihito Nagoshi, Rei Kashiwagi, Yoshiaki Toyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Although human induced pluripotent stem cell (hiPSC) derivatives are considered promising cellular resources for regenerative medicine, their tumorigenicity potentially limits their clinical application in hiPSC technologies. We previously demonstrated that oncogenic hiPSC-derived neural stem/progenitor cells (hiPSC-NS/PCs) produced tumor-like tissues that were distinct from teratomas. To gain insight into the mechanisms underlying the regulation of tumorigenicity in hiPSC-NS/PCs, we performed an integrated analysis using the Infinium HumanMethylation450 BeadChip array and the HumanHT-12 v4...
January 31, 2017: Stem Cells
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