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https://www.readbyqxmd.com/read/29786909/a-new-composite-electrode-applied-for-studying-the-electrochemistry-of-insoluble-particles-%C3%AE-hgs
#1
Minjun Yang, Richard G Compton
The redox chemistry of solid α-HgS particles is revealed using a carbon/PVDF composite containing α-HgS, carbon black, polyvinylidene fluoride (PVDF). The electrochemical behaviour of the carbon/PVDF composite is first characterised with three water insoluble organic solids. Then the reduction of solid α-HgS particles is investigated and found to occur at a high negative potential, -1.82V vs saturated mercury sulphate reference electrode, to form metallic mercury and sulphide ions. The subsequent oxidation of metallic mercury and sulphide occurs at +0...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29785762/special-award-in-synthetic-organic-chemistry-japan-for-koji-nakanishi-european-federation-for-medicinal-chemistry-awards
#2
(no author information available yet)
No abstract text is available yet for this article.
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29785499/on-the-current-role-of-hydratases-in-biocatalysis
#3
REVIEW
Matthias Engleder, Harald Pichler
Water addition to carbon-carbon double bonds provides access to value-added products from inexpensive organic feedstock. This interesting but relatively little-studied reaction is catalysed by hydratases in a highly regio- and enantiospecific fashion with excellent atom economy. Considering that asymmetric hydration of (non-activated) carbon-carbon double bonds is virtually impossible with current organic chemistry, enzymatic hydration reactions are highly attractive for industrial applications. Hydratases have been known for several decades but their biocatalytic potential has only been explored over the past 15 years...
May 21, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29785431/slow-magnetic-relaxation-and-luminescence-properties-in-lanthanide-iii-anil-complexes
#4
Diamantoula Maniaki, Ioannis Mylonas-Margaritis, Julia Mayans, Aikaterini Savvidou, Catherine P Raptopoulou, Vlasoula Bekiari, Vassilis Psycharis, Albert Escuer, Spyros P Perlepes
The initial use of anils, i.e. bidentate Schiff bases derived from the condensation of anilines with salicylaldehyde or its derivatives, in 4f-metal chemistry is described. The 1 : 1 reactions between Ln(NO3)3·xH2O (Ln = lanthanide) or Y(NO3)3·6H2O and N-(5-bromosalicylidene)aniline (5BrsalanH) in MeCN has provided access to complexes [Ln(NO3)3(5BrsalanH)2(H2O)]·MeCN (Ln = Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb) and [Y(NO3)3(5BrsalanH)2(H2O)]·MeCN, respectively, in good yields. The structures of the isomorphous complexes with Ln = Pr(1·MeCN), Sm(3·MeCN), Gd(5·MeCN), Dy(7·MeCN) and Er(9·MeCN) have been determined by single-crystal X-ray crystallography...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29782690/stable-carboxylate-terminated-gold-surfaces-produced-by-spontaneous-grafting-of-an-alkyl-tin-compound
#5
Mayreli Ortiz, Ahmed Mehdi, Christophe Methivier, Serge Thorimbert, Bernold Hasenknopf, Ciara K O'Sullivan
Self-assembled monolayers formed by chemisorption of thiolated molecules on gold surfaces are widely applied for biosensing. Moreover, and due to the low stability of thiol-gold chemistry, contributions to the functionalisation of gold substrates with linkers that provide a more stable platform for the immobilisation of electroactive or biological molecules are highly appreciated. In the work reported here, we demonstrate that a carboxylated organotin compound can be successfully grafted onto gold substrates to form a highly stable organic layer with reactivity for subsequent binding to an aminated molecule...
May 21, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29782519/increased-circulating-microrna-122-is-a-biomarker-for-discrimination-and-risk-stratification-in-patients-defined-by-sepsis-3-criteria
#6
Tim Rahmel, Simon T Schäfer, Ulrich H Frey, Michael Adamzik, Jürgen Peters
BACKGROUND: Sepsis is now operationally defined as life-threatening organ dysfunction caused by an infection, identified by an acute change in SOFA-Score of at least two points, including clinical chemistry such as creatinine or bilirubin concentrations. However, little knowledge exists about organ-specific microRNAs as potentially new biomarkers. Accordingly, we tested the hypotheses that micro-RNA-122, the foremost liver-related micro-RNA (miR), 1) discriminates between sepsis and infection, 2) is an early predictor for mortality, and 3) improves the prognostic value of the SOFA-score...
2018: PloS One
https://www.readbyqxmd.com/read/29782168/rapid-aqueous-phase-hydrolysis-of-ester-hydroperoxides-arising-from-criegee-intermediates-and-organic-acids
#7
Ran Zhao, Christopher M Kenseth, Yuanlong Huang, Nathan F Dalleska, Xiaobi Michelle Kuang, Jierou Chen, Suzanne E Paulson, John H Seinfeld
Stabilized Criegee intermediates react with organic acids in the gas phase and at the air-water interface to form a class of ester hydroperoxides, α-acyloxyalkyl hydroperoxides (αAAHPs). A number of recent studies have proposed the importance of αAAHPs to the formation and growth of secondary organic aerosol (SOA). The chemistry of αAAHPs has not been investigated due to a lack of commercially available chemical standards. In this work, the behavior of αAAHPs in condensed phases is investigated for the first time...
May 21, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29780983/the-predictive-power-of-aromaticity-quantitative-correlation-between-aromaticity-and-ionization-potentials-and-homo-lumo-gaps-in-oligomers-of-benzene-pyrrole-furan-and-thiophene
#8
Renana Gershoni-Poranne, Anuja P Rahalkar, Amnon Stanger
Aromaticity is a central and ubiquitous concept in organic chemistry, and is used extensively to explain various phenomena. Yet, aromaticity cannot be observed or measured as a property in its own right and, to date, only qualitative and semi-quantitative relationships have been described between aromaticity and an observable property. We now demonstrate for the first time a robust quantitative relationship between the HOMO-LUMO gap and adiabatic ionization potential of a polycyclic aromatic hydrocarbon oligomer - both measurable physical quantities - and its aromaticity, as quantified by the Nucleus Independent Chemical Shift (NICS) index...
May 21, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29780551/protein-surface-functionalisation-as-a-general-strategy-for-facilitating-biomimetic-mineralisation-of-zif-8
#9
Natasha K Maddigan, Andrew Tarzia, David M Huang, Christopher J Sumby, Stephen G Bell, Paolo Falcaro, Christian J Doonan
The durability of enzymes in harsh conditions can be enhanced by encapsulation within metal-organic frameworks (MOFs) via a process called biomimetic mineralisation. Herein we show that the surface charge and chemistry of a protein determines its ability to seed MOF growth. We demonstrate that chemical modification of amino acids on the protein surface is an effective method for systematically controlling biomimetic mineralisation by zeolitic imidazolate framework-8 (ZIF-8). Reaction of surface lysine residues with succinic (or acetic) anhydride facilitates biomimetic mineralisation by increasing the surface negative charge, whereas reaction of surface carboxylate moieties with ethylenediamine affords a more positively charged protein and hinders the process...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779661/characterization-and-biochemical-assays-of-streptomyces-vanadium-dependent-chloroperoxidases
#10
Shaun M K McKinnie, Zachary D Miles, Bradley S Moore
Vanadium-dependent haloperoxidases (VHPOs) are fascinating enzymes that facilitate electrophilic halogen incorporation into electron-rich substrates, simply requiring vanadate, a halide source, and cosubstrate hydrogen peroxide for activity. Initially characterized in fungi and red algae, VHPOs were long believed to have limited regio-, chemo-, and enantioselectivity in the production of halogenated metabolites. However, the recent discovery of homologues in the biosynthetic gene clusters of the stereoselectively halogenated meroterpenoids from marine-derived Streptomyces bacteria has revised this paradigm...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29778594/differetial-toxin-profiles-of-ciguatoxins-in-marine-organisms-chemistry-fate-and-global-distribution
#11
REVIEW
Lucía Soliño, Pedro Reis Costa
Ciguatoxins (CTXs) are fish metabolism products and a result of biotransformation of precursor gambiertoxins produced, in the first instance, by benthic dinoflagellates Gambierdiscus and Fukuyoa. Ciguatoxins are potent neurotoxins that selectively open voltage gated sodium channels in excitable cells causing the human food poisoning known as Ciguatera (CFP). Endemic from tropical areas in central Pacific and West Indian Ocean, and the Caribbean Sea, CTX may affects up to 500,000 people annually due to fish consumption...
May 17, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29776931/shuffling-the-neutral-drift-of-unspecific-peroxygenase-in-saccharomyces-cerevisiae
#12
Javier Martin-Diaz, Carmen Paret, Eva García-Ruiz, Patricia Molina-Espeja, Miguel Alcalde
Unspecific peroxygenase (UPO) is a highly promiscuous biocatalyst and its selective mono(per)oxygenase activity makes it useful for many synthetic chemistry applications. Among the broad repertory of library creation methods for directed enzyme evolution, genetic drift allows neutral mutations to be accumulated gradually within a polymorphic network of variants. In this study, we conducted a campaign of genetic drift with UPO in Saccharomyces cerevisiae so that neutral mutations were simply added and recombined in vivo With low mutational loading and an activity threshold of 45% of the parent's native function, mutant libraries enriched in folded and active UPO variants were generated...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29775816/understanding-the-role-of-hydrogen-bonding-in-the-aggregation-of-fumed-silica-particles-in-triglyceride-solvents
#13
Catherine P Whitby, Melinda Krebsz, Samuel J Booty
HYPOTHESIS: Fumed silica particles are thought to thicken organic solvents into gels by aggregating to form networks. Hydrogen bonding between silanol groups on different particle surfaces causes the aggregation. The gel structure and hence flow behaviour is altered by varying the proportion of silanol groups on the particle surfaces. However, characterising the gel using rheology measurements alone is not sufficient to optimise the aggregation. We have used confocal microscopy to characterise the changes in the network microstructure caused by altering the particle surface chemistry...
May 12, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29775058/multiple-click-selective-trna-synthetases-expand-mammalian-cell-specific-proteomics
#14
Andrew C Yang, Haley du Bois, Niclas Olsson, David Gate, Benoit Lehallier, Daniela Berdnik, Kyle D Brewer, Carolyn R Bertozzi, Joshua E Elias, Tony Wyss-Coray
Bio-orthogonal tools enable cell-type-specific proteomics, a prerequisite to understanding biological processes in multicellular organisms. Here we report two engineered aminoacyl-tRNA synthetases for mammalian bio-orthogonal labeling: a tyrosyl ( ScTyrY34G ) and a phenylalanyl ( MmPheT412G ) tRNA synthetase that incorporate azide-bearing noncanonical amino acids specifically into the nascent proteomes of host cells. Azide-labeled proteins are chemoselectively tagged via azide-alkyne cycloadditions with fluorophores for imaging or affinity resins for mass spectrometric characterization...
May 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29775048/selective-crystallization-of-four-tungstates-la-2-w-3-o-12-la-2-w-2-o-9-la-14-w-8-o-45-and-la-6-w-2-o-15-via-hydrothermal-reaction-and-comparative-study-of-eu-3-luminescence
#15
Xiaofei Shi, Zhihao Wang, Toshiaki Takei, Xuejiao Wang, Qi Zhu, Xiaodong Li, Byung-Nam Kim, Xudong Sun, Ji-Guang Li
Hydrothermal reaction at 200 °C was systematically undertaken in wide ranges of solution pH (4-13) and W/La molar ratio ( R = 0.5-2), without using any organic additive, to investigate the effect of hydrothermal parameter on product property and the underlying mechanism. Combined analysis by X-ray diffraction (XRD), inductively coupled plasma (ICP) spectroscopy, elemental mapping, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that either a decreasing pH or increasing R value yielded a product richer in W and, conversely, richer in La...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29774651/visible-light-induced-organic-photochemical-reactions-via-energy-transfer-pathways
#16
Wen-Jing Xiao, Quan-Quan Zhou, You-Quan Zou, Liang-Qiu Lu
Visible-light photocatalysis is a rapidly developing and powerful strategy to initiate organic transformations as it closely adheres to the tenants of green and sustainable chemistry. Generally, most visible-light-induced photochemical reactions occur through single-electron transfer (SET) pathways. Recently, visible-light-induced energy transfer (EnT) reactions have received considerable attentions from the synthetic community as this strategy provides a distinct reaction pathway, and remarkable achievements have been made in this field...
May 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29774646/chiral-isocamphoric-acid-founding-a-large-family-of-homochiral-porous-materials
#17
Xiang Zhao, Edward T Nguyen, Anh N Hong, Pingyun Feng, Xianhui Bu
Homochiral metal-organic frameworks (MOFs) are an important class of chiral solids with potential applications in chiral recognition; however, relatively few are available. Of great importance is the availability of low-cost, racemization-resistant, and versatile enantiopure building blocks. Among chiral building blocks, d-camphoric acid is highly prolific, yet, its trans-isomer, l-isocamphoric acid, has remained unknown in the entire field of solid-state materials. Its rich yet totally untapped synthetic and structural chemistry has now been investigated through the synthesis of a large family of homochiral metal isocamphorates...
May 17, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29774614/photochemistry-for-well-defined-polymers-in-aqueous-media-from-fundamentals-to-polymer-nanoparticles-to-bioconjugates
#18
REVIEW
Kevin M Burridge, Thaiesha A Wright, Richard C Page, Dominik Konkolewicz
This review article highlights recent developments in the field of photochemistry and photochemical reversible deactivation radical polymerization applied to aqueous polymerizations. Photochemistry is a topic of significant interest in the fields of organic, polymer, and materials chemistry because it allows challenging reactions to be performed under mild conditions. Aqueous polymerization is of significant interest because water is an environmentally benign solvent, and the use of water enables complex polymer self-assembly and bioconjugation processes to occur...
May 17, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29774348/a-new-series-of-co-ni-zn-and-cd-metal-organic-architectures-driven-by-an-unsymmetrical-biphenyl-tricarboxylic-acid-hydrothermal-assembly-structural-features-and-properties
#19
Jin-Zhong Gu, Yan Cai, Zi-Yue Qian, Min Wen, Zi-Fa Shi, Dong-Yu Lv, Alexander M Kirillov
This study reports the hydrothermal synthesis of a novel series of twelve coordination compounds, namely, {[Cd(μ-Hnbtc)(H2O)4]·H2O}n (1), [Zn2(μ-Hnbtc)2(phen)2]·2H2O (2), [Zn(Hnbtc)(phen)2(H2O)]·4.5H2O (3), [Ni(Hnbtc)(phen)2(H2O)]·6H2O (4), [Zn2(μ-Hnbtc)2(2,2'-bipy)2]·2H2O (5), [Cd3(μ5-nbtc)(μ6-nbtc)(2,2'-bipy)2(H2O)]n (6), {[Zn3(μ3-nbtc)2(phen)3(H2O)2]·4H2O} (7), [Co(H2O)6][Co2(nbtc)2(μ-4,4'-bipy)(4,4'-bipy)2(H2O)6]·8H2O (8), {[Ni3(μ4-nbtc)2(μ-4,4'-bipy)2.5(μ-H2O)(H2O)3]·4H2O}n (9), {[Cd2(μ4-nbtc)(μ-OH)(2,2'-bipy)2]·H2O}n (10), [Cd2(μ4-nbtc)(μ-OH)(phen)2(H2O)]n (11), and {[Zn2(μ5-nbtc)(μ3-OH)(μ-4,4'-bipy)]·4,4'-bipy·H2O}n (12), which are derived from 3'-nitro-biphenyl-2,4,4'-tricarboxylic acid (H3nbtc) as a virtually unexplored building block...
May 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29774338/trace-metals-in-oysters-molecular-and-cellular-mechanisms-and-ecotoxicological-impacts
#20
REVIEW
Wen-Xiong Wang, Jie Meng, Nanyan Weng
Oysters are important benthic bivalves in coastal and estuarine environments. They are widely farmed due to their rapid growth and taste; they are also widely applied in environmental monitoring of coastal pollution due to their accumulation of contaminants. Most importantly, oysters are among the few marine organisms that are considered to be hyper-accumulators of many toxic metals, such as cadmium, copper and zinc. As such, there is a tremendous call to study the interactions between metals and oysters, especially due to the increasing metal pollution in many coastal and estuarine waters...
May 18, 2018: Environmental Science. Processes & Impacts
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