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https://www.readbyqxmd.com/read/29777887/linear-cutting-trepanation-in-italy-a-unique-case-from-hellenistic-sicily-3-rd-century-bc
#1
REVIEW
Giorgia Tulumello, Giulia Riccomi, Simona Minozzi, Sveva Longo, Marcello Longo, Valentina Giuffra
During the archaeological excavations conducted in the Hellenistic necropolis discovered in Messina (Sicily, Italy) dating back to the 3rd century BC., a skeleton showing evidence of cranial traumas and surgical intervention was found. The skull, belonging to a young adult male, presented signs of four head injuries produced by both blunt and sharp-edged instruments. The first two lesions, located on the frontal bone, were produced by blunt blows and showed signs of long-time survival. The third lesion, located on the inferior portion of the right parietal, suggests a perimortem non-penetrating linear cut probably caused by a blade instrument...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29776637/an-update-regarding-the-molecular-genetics-of-melanocytic-neoplasms-and-the-current-applications-of-molecular-genetic-technologies-in-their-diagnosis-and-treatment
#2
REVIEW
Katrin Kiavash, Martin H Bluth, Andrew David Thompson
Molecular genetic technologies are used to aid in diagnosis and treatment of borderline melanocytic tumors as an adjuvant to the gold standard histopathologic evaluation. A specific set of fluorescence in situ hybridization probes is widely used to aid in diagnosing challenging melanocytic lesions. New melanoma probe cocktails have revealed increased sensitivity and specificity in ambiguous melanocytic cases. Array comparative genomic hybridization is a more complex technology used for the work-up of diagnostically problematic Spitzoid melanocytic proliferations...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29775625/reduction-sensitive-polymeric-nanomedicines-an-emerging-multifunctional-platform-for-targeted-cancer-therapy
#3
Huanli Sun, Yifan Zhang, Zhiyuan Zhong
The development of smart delivery systems that are robust in circulation and quickly release drugs following selective internalization into target cancer cells is a key to precision cancer therapy. Interestingly, reduction-sensitive polymeric nanomedicines showing high plasma stability and triggered cytoplasmic drug release behavior have recently emerged as one of the most exciting platforms for targeted delivery of various anticancer drugs including small chemical drugs, proteins, and nucleic acids. In vivo studies in varying tumor models reveal that these reduction-sensitive multifunctional nanomedicines outperform the currently used clinical formulations and reduction-insensitive counterparts, bringing about not only significantly enhanced tumor selectivity, accumulation and inhibition efficacy but also markedly reduced systemic toxicity and improved therapeutic index...
May 15, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29775357/finding-the-optimal-nets-for-self-folding-kirigami
#4
N A M Araújo, R A da Costa, S N Dorogovtsev, J F F Mendes
Three-dimensional shells can be synthesized from the spontaneous self-folding of two-dimensional templates of interconnected panels, called nets. However, some nets are more likely to self-fold into the desired shell under random movements. The optimal nets are the ones that maximize the number of vertex connections, i.e., vertices that have only two of its faces cut away from each other in the net. Previous methods for finding such nets are based on random search, and thus, they do not guarantee the optimal solution...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29771516/adaptive-geometric-networks-for-efficient-coarse-grained-ab-initio-molecular-dynamics-with-post-hartree-fock-accuracy
#5
Timothy C Ricard, Cody Haycraft, Srinivasan Sesha Iyengar
We introduce a new coarse-graining technique for ab initio molecular dynamics that is based on the adaptive generation of connected geometric networks or graphs specific to a given molecular ge- ometry. The coarse-grained nodes depict a local chemical environment and are networked to create edges, triangles, tetrahedrons and higher order simplexes based on (a) a Delaunay triangulation procedure and (b) a method that is based on molecular, bonded and non-bonded, local interac- tions. The geometric sub-entities thus created, that is nodes, edges, triangles, and tetrahedrons, each represent an energetic measure for a specific portion of the molecular system, capturing a spe- cific set of interactions...
May 17, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29763481/cutting-edge-technology-in-dermatology-virtual-reality-and-artificial-intelligence
#6
Giselle Prado, Carrie Kovarik
No abstract text is available yet for this article.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29761524/the-24th-annual-prostate-cancer-foundation-scientific-retreat-report
#7
REVIEW
Andrea K Miyahira, Howard R Soule
INTRODUCTION: The 24th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held from October 5-7, 2017, at the Omni Shoreham Hotel in Washington, DC. METHODS: The PCF Scientific Retreat is a scientific conference that specifically focuses on cutting edge research deemed to have significant promise for accelerating advances in prostate cancer biology and treatment. RESULTS: Themes highlighted at this year's meeting included: (i) new understandings in prostate cancer biology and disease progression; (ii) new mechanisms and treatment targets in advanced prostate cancer; (iii) advances in precision medicine genomics, germline genetics, and selection of targeted therapies; (iv) PSMA-targeted agents for PET imaging and radionuclide therapy; (v) approaches for improving the efficacy of immunotherapy in prostate cancer; (vi) applications of 3D Genomics in prostate cancer research; and (vii) potential applications of artificial intelligence in prostate cancer...
May 15, 2018: Prostate
https://www.readbyqxmd.com/read/29758694/front-propagation-and-clustering-in-the-stochastic-nonlocal-fisher-equation
#8
Yehuda A Ganan, David A Kessler
In this work, we study the problem of front propagation and pattern formation in the stochastic nonlocal Fisher equation. We find a crossover between two regimes: a steadily propagating regime for not too large interaction range and a stochastic punctuated spreading regime for larger ranges. We show that the former regime is well described by the heuristic approximation of the system by a deterministic system where the linear growth term is cut off below some critical density. This deterministic system is seen not only to give the right front velocity, but also predicts the onset of clustering for interaction kernels which give rise to stable uniform states, such as the Gaussian kernel, for sufficiently large cutoff...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756237/biopolymers-for-antitumor-implantable-drug-delivery-systems-recent-advances-and-future-outlook
#9
REVIEW
Sepehr Talebian, Javad Foroughi, Samantha J Wade, Kara L Vine, Alireza Dolatshahi-Pirouz, Mehdi Mehrali, João Conde, Gordon G Wallace
In spite of remarkable improvements in cancer treatments and survivorship, cancer still remains as one of the major causes of death worldwide. Although current standards of care provide encouraging results, they still cause severe systemic toxicity and also fail in preventing recurrence of the disease. In order to address these issues, biomaterial-based implantable drug delivery systems (DDSs) have emerged as promising therapeutic platforms, which allow local administration of drugs directly to the tumor site...
May 13, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29755971/impact-of-increasing-levels-of-oxygen-consumption-on-the-evolution-of-color-phenolic-and-volatile-compounds-of-nebbiolo-wines
#10
Maurizio Petrozziello, Fabrizio Torchio, Federico Piano, Simone Giacosa, Maurizio Ugliano, Antonella Bosso, Luca Rolle
Since the end of the last century, many works have been carried out to verify the effect of controlled oxygen intake on the chemical and organoleptic characteristics of red wines. In spite of the large number of studies on this subject, oxygen remains a cutting-edge research topic in oenology. Oxygen consumption leads to complex and not univocal changes in wine composition, sometimes positive such as color stabilization, softening of mouthfeel, increase of aroma complexity. However, the variability of these effects, which depend both on the oxygenation conditions and the composition of the wine, require more efforts in this research field to effectively manage wine oxygen exposure...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29755580/finding-local-genome-rearrangements
#11
Pijus Simonaitis, Krister M Swenson
Background: The double cut and join (DCJ) model of genome rearrangement is well studied due to its mathematical simplicity and power to account for the many events that transform gene order. These studies have mostly been devoted to the understanding of minimum length scenarios transforming one genome into another. In this paper we search instead for rearrangement scenarios that minimize the number of rearrangements whose breakpoints are unlikely due to some biological criteria. One such criterion has recently become accessible due to the advent of the Hi-C experiment, facilitating the study of 3D spacial distance between breakpoint regions...
2018: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/29755388/structural-equation-modeling-with-many-variables-a-systematic-review-of-issues-and-developments
#12
Lifang Deng, Miao Yang, Katerina M Marcoulides
Survey data in social, behavioral, and health sciences often contain many variables ( p ). Structural equation modeling (SEM) is commonly used to analyze such data. With a sufficient number of participants ( N ), SEM enables researchers to easily set up and reliably test hypothetical relationships among theoretical constructs as well as those between the constructs and their observed indicators. However, SEM analyses with small N or large p have been shown to be problematic. This article reviews issues and solutions for SEM with small N , especially when p is large...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29752768/highly-elastic-organic-crystals-for-flexible-optical-waveguides
#13
Hongyu Zhang, Huapeng Liu, Zhuoqun Lu, Zuolun Zhang, Yue Wang
The study of elastic organic single crystals (EOSCs) has emerged as a cutting-edge research of crystal engineering. Although a few EOSCs have been reported recently, those suitable for optical/optoelectronic applications have not been realized. Here, we report an elastic crystal of a Schiff base, (E)-1-(4-(dimethylamino)phenyl)iminomethyl-2-hydroxyl-naphthalene. The crystal is highly bendable under external stress and able to regain immediately its original straight shape when the stress is released. It displays bright orange-red emission with a high fluorescence quantum yield of 0...
May 12, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29750539/short-term-high-precision-radiotherapy-for-early-prostate-cancer-with-concomitant-boost-to-the-dominant-lesion-ad-interim-analysis-and-preliminary-results-of-phase-ii-trial-airc-ig-13218
#14
Giorgia Timon, Delia Ciardo, Alessia Bazani, Giulia Marvaso, Giulia Riva, Stefania Volpe, Stefania Volpe, Giuseppe Renne, Giuseppe Petralia, Dario Zerini, Damaris Patricia Rojas, Samantha Dicuonzo, Davide Maestri, Floriana Pansini, Raffaella Cambria, Cristiana Fodor, Federica Cattani, Federica Golino, Valerio Scroffi, Daniela De Lorenzo, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
OBJECTIVE: To report preliminary results of a cutting edge extreme hypofractionated treatment with concomitant boost to the dominant lesion for patients with early stage prostate cancer (PCa). METHODS: AIRC-IG-13218 is a prospective phase II trial started in June 2015. Patients with low and intermediate risk PCa who met the inclusion criteria underwent extreme hypofractionated radiotherapy to the prostate (36.25 Gy in 5 fractions) and a simultaneous integrated boost to the dominant intraprostatic lesion (DIL) to 37...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29745051/innovation-in-organ-transplantation-a-meeting-report
#15
Jay A Fishman, Melissa Greenwald
This workshop targeted opportunities to stimulate transformative innovation in organ transplantation. Participants reached consensus regarding the following: 1) Mechanisms are needed to improve the coordination of policy and oversight activities, given overlapping responsibilities for transplantation and clinical investigation among federal agencies. Innovative clinical trials span traditional administrative boundaries and include stakeholders with diverse interests. Participants identified the need for a governmental inter-agency working group to coordinate nation-wide transplant-related activities...
May 9, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29740698/meeting-report-31st-international-mammalian-genome-conference-mammalian-genetics-and-genomics-from-molecular-mechanisms-to-translational-applications
#16
REVIEW
Gabriela Sánchez-Andrade, Jacob Moskowitz, Selene Howe, Teresa M Gunn
High on the Heidelberg hills, inside the Advanced Training Centre of the European Molecular Biology Laboratory (EMBL) campus with its unique double-helix staircase, scientists gathered for the EMBL conference "Mammalian Genetics and Genomics: From Molecular Mechanisms to Translational Applications," organized in cooperation with the International Mammalian Genome Society (IMGS) and the Mouse Molecular Genetics (MMG) group. The conference attracted 205 participants from 30 countries, representing 6 of the 7 continents-all except Antarctica...
May 8, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29737392/back-to-the-past-deciphering-cultural-heritage-secrets-by-protein-identification
#17
REVIEW
Maria Gabriella Giuffrida, Roberto Mazzoli, Enrica Pessione
The present review article reports the most innovative methods to detect proteins in historical and archeological samples as well as to characterize proteins used as binders in artworks. Difficulties to ascribe proteins to a certain animal species are often due to post-translational modifications originated by chemical or microbial deterioration during aging. Combining different techniques such as peptide mass fingerprinting and tandem mass spectrometry can solve some of these problems and also allow discrimination between taxonomically related species like sheep and goat...
May 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29733683/biobanking-in-a-challenging-african-environment-unique-experience-from-the-siren-project
#18
Rufus O Akinyemi, Kazeem Akinwande, Samuel Diala, Osi Adeleye, Abiodun Ajose, Kehinde Issa, Dorcas Owusu, Isaac Boamah, Isah Suleiman Yahaya, Abdulraheem Olayemi Jimoh, Lucius Imoh, Gregory Fakunle, Albert Akpalu, Fred Sarfo, Kolawole Wahab, Emmanuel Sanya, Lukman Owolabi, Reginald Obiako, Godwin Osaigbovo, Morenikeji Komolafe, Michael Fawale, Philip Adebayo, Paul Olowoyo, Yahaya Obiabo, Taofiki Sunmonu, Ijezie Chukwuonye, Olayemi Balogun, Basirat Adeoye, Florence Oladele, Peter Olowoniyi, Frederick Adeyemi, Arthur Lezzi, Ajibola Tunde Falayi, Michael Fasanya, Kolawole Ogunwale, Olabisi Adeola, Omolara Olomu, Olumayowa Aridegbe, Ruth Laryea, Ezinne Uvere, Moyinoluwalogo Faniyan, Ezinne Melikam, Raelle Tagge, Onoja Akpa, Joshua Akinyemi, Oyedunni Arulogun, Hemant K Tiwari, Bruce Ovbiagele, Mayowa Owolabi
Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational, multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from 16 sites in Ghana and Nigeria...
May 7, 2018: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29733105/co-crystals-of-2-amino-5-nitropyridine-barbital-with-extreme-birefringence-and-large-second-harmonic-generation-effect
#19
Marlena Gryl, Tomasz Seidler, Joanna Wojnarska, Katarzyna Marta Stadnicka, Irena Matulková, Ivan Němec, Petr Němec
Technological innovation enforces a revolutionized approach towards materials chemistry. In this manuscript a new methodology towards crystal engineering of polar materials for possible applications in linear or non-linear optics, as ferroelectric, pyroelectric or piezoelectric crystals has been presented. The necessity to fulfil several criteria concerning symmetry, electron properties of the building blocks and also mechanical and optical stability was achieved by fusion of pharmaceutical molecule and NLO-phore...
May 7, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29727293/croi-2018-advances-in-basic-science-understanding-of-hiv
#20
Mario Stevenson
The conference on Retroviruses and Opportunistic Infections represents the most important venue for the dissemination of research advances in HIV and AIDS. The 25th conference, held in Boston, featured presentations that provided insight into the mechanisms of HIV-1 spread in tissues as well as new information on mechanisms of HIV-1 persistence in individuals on effective antiretroviral treatment. The ability of the conference to convey research findings for a general audience is enhanced, to a large part, by preconference workshops...
May 2018: Topics in Antiviral Medicine
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