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https://www.readbyqxmd.com/read/29352041/stress-signaling-jnk2-crosstalk-with-camkii-underlies-enhanced-atrial-arrhythmogenesis
#1
Jiajie Yan, Weiwei Zhao, Justin K Thomson, Xianlong Gao, Dominic M DeMarco, Elena Carrillo, Biyi Chen, Xiaomin Wu, Kenneth S Ginsburg, Mamdouh Bakhos, Donald M Bers, Mark E Anderson, Long-Sheng Song, Michael Fill, Xun Ai
Rationale: Atrial fibrillation (AF) is the most common arrhythmia and advanced age is an inevitable and predominant AF risk factor. However, the mechanisms that couple aging and AF propensity remain unclear, making targeted therapeutic interventions unattainable. Objective: To explore the functional role of an important stress-response c-Jun N-terminal kinase (JNK) in sarcoplasmic reticulum (SR) Ca2+ handling and consequently Ca2+-mediated atrial arrhythmias. Methods and Results: We employed a series of cutting-edge electrophysiological and molecular techniques, exploited the power of transgenic mouse models to detail the molecular mechanism, and verified its clinical applicability in parallel studies on donor human hearts...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29349629/cerebellum-from-development-to-disease-the-8th-international-symposium-of-the-society-for-research-on-the-cerebellum-and-ataxias
#2
EDITORIAL
Hassan Marzban, Mario Manto, Jean Mariani
In recent years, there has been tremendous growth in research on cerebellar motor and non-motor functions. Cerebellum is particularly involved in the spectrum of neurodevelopmental diseases. The 8th International Symposium of the Society for Research on the Cerebellum and Ataxia (SRCA) was held in Winnipeg, Manitoba, (Canada) on May 24-26, 2017. The main theme of the 8th International Symposium was "Development of the Cerebellum and Neurodevelopmental Disorders." Advances in genetics, epigenetic, cerebellar neurogenesis, axonogenesis and gliogenesis, cerebellar developmental disorders including autism spectrum disorders (ASD), neuroimaging, cerebellar ataxias, medulloblastoma, and clinical investigation of cerebellar diseases were presented...
January 18, 2018: Cerebellum
https://www.readbyqxmd.com/read/29346157/identifying-novel-signaling-pathways-an-exercise-scientists-guide-to-phosphoproteomics
#3
Gary M Wilson, Rocky Blanco, Joshua J Coon, Troy A Hornberger
We propose that phosphoproteomic-based studies will radically advance our knowledge about exercise regulated signaling events. However, these studies utilize cutting-edge technologies that can be difficult for non-specialists to understand. Hence, this review is intended to help non-specialists: 1) understand the fundamental technologies behind phosphoproteomic analysis and 2) employ various bioinformatic tools that can be used to interrogate phosphoproteomic datasets.
January 15, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29343069/at-the-cutting-edge-of-surface-science-a-tribute-to-miquel-b-salmeron
#4
Robert W Carpick, Gang-Yu Liu, John C Hemminger
No abstract text is available yet for this article.
January 18, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29341780/interplay-of-correlations-and-kohn-anomalies-in-three-dimensions-quantum-criticality-with-a-twist
#5
T Schäfer, A A Katanin, K Held, A Toschi
A general understanding of quantum phase transitions in strongly correlated materials is still lacking. By exploiting a cutting-edge quantum many-body approach, the dynamical vertex approximation, we make important progress, determining the quantum critical properties of the antiferromagnetic transition in the fundamental model for correlated electrons, the Hubbard model in three dimensions. In particular, we demonstrate that-in contradiction to the conventional Hertz-Millis-Moriya theory-its quantum critical behavior is driven by the Kohn anomalies of the Fermi surface, even when electronic correlations become strong...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341139/exploitation-of-the-ultraviolet-properties-and-machine-cut-edges-of-paper-to-associate-and-sequence-sheets-in-a-ream
#6
Nicola R Musgrave, Oliver T S Thorne
Previously unreported line patterns visible under ultraviolet light were observed on a proportion of plain white A4 printer/copier paper from different manufacturers. These Ultraviolet Line Patterns (UVLPs) usually appear as stripes down the vertical length of the paper. Typically, the UVLPs were found to "repeat" through the ream in a predictable way, while also changing. It is postulated that the repeating nature of the UVLPs is a result of the way that paper is manufactured. This leads to the ability to sequence the sheets compared to their original source paper...
January 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29340722/new-frontiers-and-cutting-edge-applications-in-ultra-high-performance-liquid-chromatography-through-latest-generation-superficially-porous-particles-with-particular-emphasis-to-the-field-of-chiral-separations
#7
Martina Catani, Simona Felletti, Omar H Ismail, Francesco Gasparrini, Luisa Pasti, Nicola Marchetti, Chiara De Luca, Valentina Costa, Alberto Cavazzini
About ten years after their introduction to the market (happened in 2006), the so-called second generation superficially porous particles (SPPs) have undoubtedly become the benchmark as well as, very often, the preferred choice for many applications in liquid chromatography (LC), when high efficiency and fast separations are required. This trend has interested practically all kinds of separations, with the only exception of chiral chromatography (at least so far). The technology of production of base SPPs is advanced, relatively simple and widely available...
January 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29340618/mitochondrial-toxicity
#8
Joel N Meyer, Jessica H Hartman, Danielle F Mello
Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants on mitochondria. Researchers have also documented many genetic differences leading to mitochondrial diseases, currently reported to affect ∼1 person in 4,300, creating a large number of potential gene-environment interactions in mitochondrial toxicity. We briefly review this history, and then highlight cutting-edge areas of mitochondrial research including the role of mitochondrial reactive oxygen species in signaling; increased understanding of fundamental biological processes involved in mitochondrial homeostasis (DNA maintenance and mutagenesis, mitochondrial stress response pathways, fusion and fission, autophagy and biogenesis, and exocytosis); systemic effects resulting from mitochondrial stresses in specific cell types; mitochondrial involvement in immune function; the growing evidence of long-term effects of mitochondrial toxicity; mitochondrial-epigenetic cross-talk; and newer approaches to test chemicals for mitochondrial toxicity...
January 11, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29339647/proceedings-of-the-11th-congress-of-the-international-society-of-nutrigenetics-and-nutrigenomics-isnn-2017
#9
William T Barrington, Anna C Salvador, Jaana A Hartiala, Raffaele De Caterina, Martin Kohlmeier, J Alfredo Martinez, Carin B Kreutzer, David Heber, Aldons J Lusis, Zhaoping Li, Hooman Allayee
The International Society of Nutrigenetics and Nutrigenomics (ISNN) held its 11th annual Congress in Los Angeles, California, between September 16 and 19, 2017. In addition to 2 keynote lectures, 4 plenary sessions included presentations by internationally renowned speakers on cutting-edge areas of research and new discoveries in genetics/genomics, the microbiome, and nutrition. Scientific topics included multi-omics approaches; diet and the microbiome; cancer, longevity, and metabolism; moving the field forward; and translational/educational aspects and the future of medicine...
January 17, 2018: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29339248/recent-trends-of-nanomedicinal-approaches-in-clinics
#10
REVIEW
Fahima Dilnawaz, Sarbari Acharya, Sanjeeb Kumar Sahoo
Nanotechnology has become the indispensable cutting edge science providing solutions to many problems associated with human being. The application of nanotechnology associated to human health "nanomedicine" has revolutionized the drug delivery system by providing improved pharmacological and therapeutic properties of drugs. These advantageous effects of drug loaded nanocarrier systems are embraced by the pharmaceutical industries for the development of different effective nanocarriers. Currently, several drug loaded nanoformulations are approved by the Food and Drug Administration (FDA), and some of them are undergoing clinical trials for the human use...
January 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29338479/graphene-oxide-regulates-cox2-in-human-embryonic-kidney-293t-cells-via-epigenetic-mechanisms-dynamic-chromosomal-interactions
#11
Yuxiang Sun, Hui Dai, Shaopeng Chen, Ming Xu, Xuanyu Wang, Yajun Zhang, Shengmin Xu, An Xu, Jian Weng, Sijin Liu, Lijun Wu
To extend the applications of engineered nanomaterials, such as graphene oxide (GO), it is necessary to minimize cytotoxicity. However, the mechanisms underlying this cytotoxicity are unclear. Dynamic chromosomal interactions have been used to illustrate the molecular bases of gene expression, which offers a more sensitive and cutting-edge technology to elucidate complex biological processes associated with epigenetic regulations. In this study, the role of GO-triggered chromatin interactions in the activation of cox2, a hallmark of inflammation, was investigated in normal human cells...
January 16, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29337867/tensile-and-creep-testing-of-sanicro-25-using-miniature-specimens
#12
Petr Dymáček, Milan Jarý, Ferdinand Dobeš, Luboš Kloc
Tensile and creep properties of new austenitic steel Sanicro 25 at room temperature and operating temperature 700 °C were investigated by testing on miniature specimens. The results were correlated with testing on conventional specimens. Very good agreement of results was obtained, namely in yield and ultimate strength, as well as short-term creep properties. Although the creep rupture time was found to be systematically shorter and creep ductility lower in the miniature test, the minimum creep rates were comparable...
January 16, 2018: Materials
https://www.readbyqxmd.com/read/29337720/update-on-the-role-of-actovegin-in-musculoskeletal-medicine-a-review-of-the-past-10-years
#13
James Brock, David Golding, Paul M Smith, Len Nokes, Alvin Kwan, Paul Y F Lee
BACKGROUND: Actovegin is a biological drug with a controversial history of use in the treatment of sports injuries during the past 60 years. Particular concerns have been raised about its ergogenic potential to enhance performance, but some of these have been based on little more than anecdote. OBJECTIVES: In this article, we review the most recent scientific evidence to determine the clinical efficacy, safety profile, and legal status of Actovegin. METHODS: We considered all studies directly commenting on experience with Actovegin use as the primary intervention within the past 10 years...
January 15, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29336001/advances-in-the-study-of-the-middle-cranial-fossa-through-cutting-edge-neuroimaging-techniques
#14
Juan A Juanes Méndez, Pablo Ruisoto, Juan C Paniagua, Alberto Prats
The objective of this paper is to present a morphometric study of the middle cranial fossa from the study of 87 patients using cutting edge multislice computed tomography scans (32 detectors) and Magnetic Resonance Imaging. The study presents a detailed anatomical-radiological and morphometric analysis of the middle cranial fossa as well as its neurovascular elements in normal conditions. The implications of this investigation in training and clinical contexts are discussed.
January 16, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29334192/digitalizing-self-assembled-chiral-superstructures-for-optical-vortex-processing
#15
Peng Chen, Ling-Ling Ma, Wei Duan, Ji Chen, Shi-Jun Ge, Zhi-Han Zhu, Ming-Jie Tang, Ran Xu, Wei Gao, Tao Li, Wei Hu, Yan-Qing Lu
Cholesteric liquid crystal (CLC) chiral superstructures exhibit unique features; that is, polychromatic and spin-determined phase modulation. Here, a concept for digitalized chiral superstructures is proposed, which further enables the arbitrary manipulation of reflective geometric phase and may significantly upgrade existing optical apparatus. By encoding a specifically designed binary pattern, an innovative CLC optical vortex (OV) processor is demonstrated. Up to 25 different OVs are extracted with equal efficiency over a wavelength range of 116 nm...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29331932/cnv-biology-in-neurodevelopmental-disorders
#16
REVIEW
Toru Takumi, Kota Tamada
Copy number variants (CNVs), characterized in recent years by cutting-edge technology, add complexity to our knowledge of the human genome. CNVs contribute not only to human diversity but also to different kinds of diseases including neurodevelopmental delay, autism spectrum disorder and neuropsychiatric diseases. Interestingly, many pathogenic CNVs are shared among these diseases. Studies suggest that pathophysiology of disease may not be simply attributed to a single driver gene within a CNV but also that multifactorial effects may be important...
January 10, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29331471/symposium-review-novel-strategies-to-genetically-improve-mastitis-resistance-in-dairy-cattle
#17
P Martin, H W Barkema, L F Brito, S G Narayana, F Miglior
Mastitis is a disease of major economic importance to the dairy cattle sector because of the high incidence of clinical mastitis and prevalence of subclinical mastitis and, consequently, the costs associated with treatment, production losses, and reduced animal welfare. Disease-recording systems compiling data from a large number of farms are still not widely implemented around the world; thus, selection for mastitis resistance is often based on genetically correlated indicator traits such as somatic cell count (SCC), udder depth, and fore udder attachment...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29331424/ultra-narrow-surface-lattice-resonances-in-plasmonic-metamaterial-arrays-for-biosensing-applications
#18
Artem Danilov, Gleb Tselikov, Fan Wu, Vasyl G Kravets, Igor Ozerov, Frederic Bedu, Alexander N Grigorenko, Andrei V Kabashin
When excited over a periodic metamaterial lattice of gold nanoparticles (~ 100nm), localized plasmon resonances (LPR) can be coupled by a diffraction wave propagating along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down to a few nm full-width-at-half-maximum) and the generation of singularities of phase of reflected light. These phenomena look very promising for the improvement of performance of plasmonic biosensors, but conditions of implementation of such diffractively coupled plasmonic resonances, also referred to as plasmonic surface lattice resonances (PSLR), are not always compatible with biosensing arrangement implying the placement of the nanoparticles between a glass substrate and a sample medium (air, water)...
December 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29331174/transcatheter-tricuspid-repair-the-knifeless-cutting-edge
#19
EDITORIAL
Jason J Han, Pavan Atluri
No abstract text is available yet for this article.
November 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29330957/behavioral-correlates-of-cranial-muscle-functional-morphology
#20
Adam Hartstone-Rose, Sharlene E Santana
This issue of the Anatomical Record is the first of a two-volume set that focuses on new investigations into behavioral correlates of muscle functional morphology. Much of the research on functional morphology and adaptation to specific functional niches focuses on the shapes of hard-tissues-bones and teeth. Investigations into soft-tissue anatomy tend to be predominantly descriptive with only brief allusion to ontogenetic or evolutionary origins of structures. When muscles are included in analyses of functional systems, their function tends to be oversimplified-usually considered a simple force vector connecting two osteological points, with the force treated as a constant derived from some simple calculation of muscle size...
February 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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