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https://www.readbyqxmd.com/read/27918472/a-review-of-computational-methods-for-finding-non-coding-rna-genes
#1
REVIEW
Qaisar Abbas, Syed Mansoor Raza, Azizuddin Ahmed Biyabani, Muhammad Arfan Jaffar
Finding non-coding RNA (ncRNA) genes has emerged over the past few years as a cutting-edge trend in bioinformatics. There are numerous computational intelligence (CI) challenges in the annotation and interpretation of ncRNAs because it requires a domain-related expert knowledge in CI techniques. Moreover, there are many classes predicted yet not experimentally verified by researchers. Recently, researchers have applied many CI methods to predict the classes of ncRNAs. However, the diverse CI approaches lack a definitive classification framework to take advantage of past studies...
December 3, 2016: Genes
https://www.readbyqxmd.com/read/27917363/future-therapy-for-hepatitis-b-virus-role-of-immunomodulators
#2
REVIEW
Edward A Pham, Ryan B Perumpail, Benjamin J Fram, Jeffrey S Glenn, Aijaz Ahmed, Robert G Gish
Although currently available therapies for chronic hepatitis B virus infection can suppress viremia and provide long-term benefits for patients, they do not lead to a functional cure for most patients. Advances in our understanding of the virus-host interaction and the recent remarkable success of immunotherapy in cancer offer new and promising strategies for developing immune modulators that may become important components of a total therapeutic approach to hepatitis B, some of which are now in clinical development...
2016: Current Hepatology Reports
https://www.readbyqxmd.com/read/27913631/cutting-edge-lymphotoxin-signaling-is-essential-for-clearance-of-salmonella-from-the-gut-lumen-and-generation-of-anti-salmonella-protective-immunity
#3
Joanna A Wroblewska, Yuan Zhang, Haidong Tang, Xiaohuan Guo, Cathryn Nagler, Yang-Xin Fu
The immunological components that control resolution of Salmonella infection and successful vaccination are poorly defined. In a model of chronic gastrointestinal infection, we observed that the lymphotoxin (LT) pathway is essential for the clearance and resolution of primary infection of attenuated Salmonella enterica Typhimurium strain SL3261 ΔaroA Using gnotobiotic mice, we show that LTβ receptor (LTβR) signaling and the microbiota are required to promote clearance of attenuated S. enterica Typhimurium from the gut lumen...
December 2, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27913272/the-northeast-regional-sps-meeting-update-safety-pharmacology-innovations-and-applications
#4
REVIEW
Malar Pannirselvam, Tiffini Brabham, Alfred W Botchway, Donald B Hodges, Martin Traebert, Michael K Pugsley
The Safety Pharmacology Society (SPS) held a Northeast (NE) regional meeting in Boston, MA on May 13, 2016 at the Vertex Pharmaceuticals Incorporated site. There were 103 attendees from the pharmaceutical industry, contract research organizations (CROs), academia, and global regulatory agencies. An assortment of scientific topics were presented by 7 speakers that included broad topics in the cardiovascular (organ on chip, statistical power and translation of rat cardiovascular telemetry data and dual inhibition of IKr and IKs on QT interval prolongation) and central nervous system (in vitro platform for neurotoxicity, an integrated risk assessment of suicidal ideation and behavior, and EEG advances in safety pharmacology) and a novel topic discussing preclinical challenges faced in the development of a novel gene therapy...
November 29, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27910027/recurrent-cytogenetic-abnormalities-in-acute-myeloid-leukemia
#5
John J Yang, Tae Sung Park, Thomas S K Wan
The spectrum of chromosomal abnormality associated with leukemogenesis of acute myeloid leukemia (AML) is broad and heterogeneous when compared to chronic myeloid leukemia and other myeloid neoplasms. Recurrent chromosomal translocations such as t(8;21), t(15;17), and inv(16) are frequently detected, but hundreds of other uncommon chromosomal aberrations from AML also exist. This chapter discusses 22 chromosomal abnormalities that are common structural, numerical aberrations, and other important but infrequent (less than 1 %) translocations emphasized in the WHO classification...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27901305/structural-basis-for-the-klentaq-dna-polymerase-catalyzed-incorporation-of-alkene-versus-alkyne-modified-nucleotides
#6
Andreas Marx, Audrey Hottin, Karin Betz, Kay Diederichs
Efficient incorporation of modified nucleotides by DNA polymerases is essential for many cutting-edge biomolecular technologies. The present study compares the acceptance of either alkene- or alkyne-modified nucleotides by KlenTaq DNA polymerase and provides structural insights into how 7-deaza-adenosine and thymidine with attached alkene-modifications are incorporated into the growing DNA strand. Thereby, we identified modified nucleotides, which prove to be superior substrates for KlenTaq DNA polymerase compared to their natural analogues...
November 30, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27899609/enabling-the-democratization-of-the-genomics-revolution-with-a-fully-integrated-web-based-bioinformatics-platform
#7
Po-E Li, Chien-Chi Lo, Joseph J Anderson, Karen W Davenport, Kimberly A Bishop-Lilly, Yan Xu, Sanaa Ahmed, Shihai Feng, Vishwesh P Mokashi, Patrick S G Chain
Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898268/descriptive-analysis-of-in-vitro-cutting-of-swine-mitral-cusps-comparison-of-high-power-laser-and-scalpel-blade-cutting-techniques
#8
Nathali Cordeiro Pinto, Pablo Maria Alberto Pomerantzeff, Alessandro Deana, Denise Zezell, Carolina Benetti, Vera Demarchi Aiello, Luciana Almeida Lopes, Fabio Biscegli Jatene, M Cristina Chavantes
BACKGROUND AND OBJECTIVES: The most common injury to the heart valve with rheumatic involvement is mitral stenosis, which is the reason for a big number of cardiac operations in Brazil. Commissurotomy is the traditional technique that is still widely used for this condition, although late postoperative restenosis is concerning. This study's purpose was to compare the histological findings of porcine cusp mitral valves treated in vitro with commissurotomy with a scalpel blade to those treated with high-power laser (HPL) cutting, using appropriate staining techniques...
November 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27896144/clinical-decision-support-for-drug-related-events-moving-towards-better-prevention
#9
REVIEW
Sandra L Kane-Gill, Archita Achanta, John A Kellum, Steven M Handler
Clinical decision support (CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors (ME) and adverse drug events (ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27894958/poly-adp-ribose-polymerase-inhibitors-selectively-induce-cytotoxicity-in-tcf3-hlf-positive-leukemic-cells
#10
Jinhua Piao, Shiori Takai, Takahiro Kamiya, Takeshi Inukai, Kanji Sugita, Kazuma Ohyashiki, Domenico Delia, Mitsuko Masutani, Shuki Mizutani, Masatoshi Takagi
Poly (ADP-ribose) polymerase (PARP) is an indispensable component of the DNA repair machinery. PARP inhibitors are used as cutting-edge treatments for patients with homologous recombination repair (HRR)-defective breast cancers harboring mutations in BRCA1 or BRCA2. Other tumors defective in HRR, including some hematological malignancies, are predicted to be good candidates for treatment with PARP inhibitors. Screening of leukemia-derived cell lines revealed that lymphoid lineage-derived leukemia cell lines, except for those derived from mature B cells and KMT2A (MLL)-rearranged B-cell precursors, were relatively sensitive to PARP inhibitors...
November 25, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27894235/energy-efficient-graphene-based-high-performance-capacitors
#11
Joonwon Bae, Chang-Soo Lee, Oh Seok Kwon
Graphene (GRP) is an interesting class of nano-structured electronic materials for various cutting-edge applications. To date, extensive research activities have been performed on the investigation of diverse properties of GRP. The incorporation of this elegant material can be very lucrative in terms of practical applications in energy storage/conversion systems. Among various those systems, high performance electrochemical capacitors (ECs) have become popular due to the recent need for energy efficient and portable devices...
October 27, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27893953/leveraging-telehealth-to-bring-volunteer-physicians-into-underserved-communities
#12
Lori Uscher-Pines, Robert Rudin, Ateev Mehrotra
Many disadvantaged communities lack sufficient numbers of local primary care and specialty physicians. Yet tens of thousands of physicians, in particular those who are retired or semiretired, desire meaningful volunteer opportunities. Multiple programs have begun to use telehealth to bridge the gap between volunteer physicians and underserved patients. In this brief, we describe programs that are using this model and discuss the promise and pitfalls. Physician volunteers in these programs report that the work can be fulfilling and exciting, a cutting-edge yet convenient way to remain engaged and contribute...
November 28, 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/27885572/improving-tribological-and-anti-bacterial-properties-of-titanium-external-fixation-pins-through-surface-ceramic-conversion
#13
Huan Dong, Tatiana Mukinay, Maojun Li, Richard Hood, Sein Leung Soo, Simon Cockshott, Rachel Sammons, Xiaoying Li
In this study, an advanced ceramic conversion surface engineering technology has been applied for the first time to self-drilling Ti6Al4V external fixation pins to improve their performance in terms of biomechanical, bio-tribological and antibacterial properties. Systematic characterisation of the ceramic conversion treated Ti pins was carried out using Scanning electron microscope, X-ray diffraction, Glow-discharge optical emission spectroscopy, nano- and micro-indentation and scratching; the biomechanical and bio-tribological properties of the surface engineered Ti pins were evaluated by insertion into high density bone simulation material; and the antibacterial behaviour was assessed with Staphylococcus aureus NCTC 6571...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27885077/highlights-of-the-russian-health-studies-program-and-updated-research-findings
#14
Barrett N Fountos
Recognized for conducting cutting-edge science in the field of radiation health effects research, the Department of Energy's (DOE) Russian Health Studies Program has continued to generate excitement and enthusiasm throughout its 23-year mission to assess worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union. The three goals of the Program are to: (1) clarify the relationship between health effects and chronic, low-to-medium dose radiation exposure; (2) estimate the cancer risks from exposure to gamma, neutron, and alpha radiation; and (3) provide information to the national and international organizations that determine radiation protection standards and practices...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27882576/looking-and-listening-for-learning-in-arts-and-humanities-based-creations
#15
Lara Varpio, Pamela Grassau, Pippa Hall
CONTEXT: The arts and humanities are gradually gaining a foothold in health professions education as a means of supporting the development of future clinicians who are compassionate, critical and reflexive thinkers, while also strengthening clinical skills and practices that emphasise patient-centredness, collaboration and interprofessional practices. Assignments that tap into trainee creativity are increasingly used both to prepare learners for the demands of clinical work and to understand the personal and professional challenges learners face in these contexts...
November 23, 2016: Medical Education
https://www.readbyqxmd.com/read/27882549/digest-mechanisms-of-assortative-mating-and-ecological-speciation
#16
Spencer J Ingley, Gil G Rosenthal
No abstract text is available yet for this article.
November 24, 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27875111/improving-rural-health-how-system-level-innovation-and-policy-reform-can-enhance-health-outcomes-across-the-united-states
#17
Suhas Gondi, Kavita Patel
The United States is hailed as providing the most advanced health care the world has to offer. With cutting-edge medical devices, groundbreaking procedures, and innovative technologies, our hospitals and medical centers define what the global community sees as modern biomedicine. Engineers and clinicians continue to push and reshape this standard with new inventions enabled by a rapidly developing knowledge base. However, the fruit of this advancement has not benefited Americans equally. Millions still face significant obstacles to access health care, and our rural communities in particular have been left behind (see also "The Challenge of Rural Health Care")...
November 2016: IEEE Pulse
https://www.readbyqxmd.com/read/27873381/cutting-edge-advances-in-stem-cell-biology-and-therapy
#18
EDITORIAL
Jan A Nolta
No abstract text is available yet for this article.
November 22, 2016: Stem Cells
https://www.readbyqxmd.com/read/27872304/evidence-of-isotopic-fractionation-of-natural-uranium-in-cultured-human-cells
#19
Eduardo Paredes, Emilie Avazeri, Véronique Malard, Claude Vidaud, Pascal E Reiller, Richard Ortega, Anthony Nonell, Hélène Isnard, Frédéric Chartier, Carole Bresson
The study of the isotopic fractionation of endogen elements and toxic heavy metals in living organisms for biomedical applications, and for metabolic and toxicological studies, is a cutting-edge research topic. This paper shows that human neuroblastoma cells incorporated small amounts of uranium (U) after exposure to 10 µM natural U, with preferential uptake of the (235)U isotope with regard to (238)U. Efforts were made to develop and then validate a procedure for highly accurate n((238)U)/n((235)U) determinations in microsamples of cells...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27870678/interventional-oncology-in-hepatocellular-carcinoma-progress-through-innovation
#20
Lin Mu, Julius Chapiro, Jeremiah Stringam, Jean-François Geschwind
The clinical management of hepatocellular carcinoma has evolved greatly in the last decade mostly through recent technical innovations. In particular, the application of cutting-edge image guidance has led to minimally invasive solutions for complex clinical problems and rapid advances in the field of interventional oncology. Many image-guided therapies, such as transarterial chemoembolization and radiofrequency ablation, have meanwhile been fully integrated into interdisciplinary clinical practice, whereas others are currently being investigated...
November 2016: Cancer Journal
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