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https://www.readbyqxmd.com/read/28813346/current-opinion-in-clinical-sport-psychology-from-athletic-performance-to-psychological-well-being
#1
REVIEW
Zella E Moore, Kehana Bonagura
Clinical sport psychology (CSP) is a contemporary, empirically informed model that employs a scope, style, and mode of practice built upon cutting-edge findings from both clinical and sport sciences, and that follows the sound methodological traditions of clinical psychology [1(••)]. Conceptualizing athletic performance and well-being through the context of empirical research in both athletic and nonathletic domains of functioning, CSP practice can involve the enhancement of athletic performance, and also the personal development and psychological well-being of performers...
August 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28804703/hybrid-intraoperative-imaging-techniques-in-radioguided-surgery-present-clinical-applications-and-future-outlook
#2
REVIEW
S L Bugby, J E Lees, A C Perkins
PURPOSE: This review aims to summarise the hybrid modality radioguidance techniques currently in clinical use and development, and to discuss possible future avenues of research. Due to the novelty of these approaches, evidence of their clinical relevance does not yet exist. The purpose of this review is to inform nuclear medicine practitioners of current cutting edge research in radioguided surgery which may enter standard clinical practice within the next 5-10 years. Hybrid imaging is of growing importance to nuclear medicine diagnostics, but it is only with recent advances in technology that hybrid modalities are being investigated for use during radioguided surgery...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28802195/measurements-and-simulation-of-liquid-films-during-drainage-displacements-and-snap-off-in-constricted-capillary-tubes
#3
Sophie Roman, Moataz O Abu-Al-Saud, Tetsu Tokunaga, Jiamin Wan, Anthony R Kovscek, Hamdi A Tchelepi
When a wetting liquid is displaced by air in a capillary tube, a wetting film develops between the tube wall and the air that is responsible for the snap-off mechanism of the gas phase. By dissolving a dye in the wetting phase it is possible to relate a measure of the absorbance in the capillary to the thickness of liquid films. These data could be used to compare with cutting edge numerical simulations of the dynamics of snap-off for which experimental and numerical data are lacking. Drainage experiments in constricted capillary tubes were performed where a dyed wetting liquid is displaced by air for varying flow rates...
July 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28796616/wireless-power-transfer-to-millimeter-sized-nodes-using-airborne-ultrasound
#4
Angad S Rekhi, Butrus T Khuri-Yakub, Amin Arbabian
We propose the use of airborne ultrasound for wireless power transfer to mm-sized nodes, with intended application in the next generation of the Internet of Things. We show through simulation that ultrasonic power transfer can deliver 50μW to a mm-sized node 0.88m away from a ~50 kHz, 25 cm2 transmitter array, with the peak pressure remaining below recommended limits in air, and with load power increasing with transmitter area. We report wireless power recovery measurements with a pre-charged capacitive micromachined ultrasonic transducer, demonstrating a load power of 5μW at a simulated distance of 1...
August 9, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28794231/cutting-edge-murine-nk-cells-degranulate-and-retain-cytotoxic-function-without-store-operated-calcium-entry
#5
Jacquelyn Freund-Brown, Ruth Choa, Brenal K Singh, Tanner Ford Robertson, Gabrielle M Ferry, Eric Viver, Hamid Bassiri, Janis K Burkhardt, Taku Kambayashi
Sustained Ca(2+) signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8(+) T cells require sustained Ca(2+) signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca(2+) signaling to murine NK cell function...
August 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28794102/optogenetics-and-pharmacogenetics-principles-and-applications
#6
Jingwei Jiang, Huxing Cui, Kamal Rahmouni
Remote and selective spatiotemporal control of the activity of neurons to regulate behavior and physiological functions has been a long-sought goal in system neuroscience. Identification and subsequent bioengineering of light-sensitive ion channels (e.g., channelrhodopsins, halorhodopsin and archaerhodopsins) from the bacteria has made it possible to utilize light to artificially modulate neuronal activity, namely optogenetics. Recent advance in genetics has also allowed development of novel pharmacological tools to selectively and remotely control neuronal activity using engineered G-protein coupled receptors which can be activated by otherwise inert drug-like small molecules such as the Designer Receptors Exclusively Activated by Designer Drug (DREADD) - a form of chemogenetics...
August 9, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28790279/-perioperative-management-of-fontan-operation
#7
Koichi Sughimoto, Kagami Miyaji
Surgical results of Fontan operation has been improved over the decades due to the introduction of the staged operations and some modifications of Fontan route from the classical atrio-pulmonary connection to total cavo-pulmonary connection. However, issues remain because of the single ventricular physiology of Fontan circulation. This article explains about the preoperative checklist for Fontan operation and tips on the postoperative management including an early extubation, use of inhaled nitric oxide after extubation, anticoagulation therapy, and efficacy of angiotensin converting enzyme inhibitor, supported by the cutting-edge evidence...
July 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28781745/developing-a-strategy-for-computational-lab-skills-training-through-software-and-data-carpentry-experiences-from-the-elixir-pilot-action
#8
Aleksandra Pawlik, Celia W G van Gelder, Aleksandra Nenadic, Patricia M Palagi, Eija Korpelainen, Philip Lijnzaad, Diana Marek, Susanna-Assunta Sansone, John Hancock, Carole Goble
Quality training in computational skills for life scientists is essential to allow them to deliver robust, reproducible and cutting-edge research. A pan-European bioinformatics programme, ELIXIR, has adopted a well-established and progressive programme of computational lab and data skills training from Software and Data Carpentry, aimed at increasing the number of skilled life scientists and building a sustainable training community in this field. This article describes the Pilot action, which introduced the Carpentry training model to the ELIXIR community...
2017: F1000Research
https://www.readbyqxmd.com/read/28773919/high-speed-edge-trimming-of-cfrp-and-online-monitoring-of-performance-of-router-tools-using-acoustic-emission
#9
Rangasamy Prakash, Vijayan Krishnaraj, Redouane Zitoune, Jamal Sheikh-Ahmad
Carbon fiber reinforced polymers (CFRPs) have found wide-ranging applications in numerous industrial fields such as aerospace, automotive, and shipping industries due to their excellent mechanical properties that lead to enhanced functional performance. In this paper, an experimental study on edge trimming of CFRP was done with various cutting conditions and different geometry of tools such as helical-, fluted-, and burr-type tools. The investigation involves the measurement of cutting forces for the different machining conditions and its effect on the surface quality of the trimmed edges...
September 26, 2016: Materials
https://www.readbyqxmd.com/read/28773109/thermomechanical-properties-of-polylactic-acid-graphene-composites-a-state-of-the-art-review-for-biomedical-applications
#10
REVIEW
Ilker S Bayer
Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers...
July 4, 2017: Materials
https://www.readbyqxmd.com/read/28773092/experimental-and-computational-studies-on-the-scattering-of-an-edge-guided-wave-by-a-hidden-crack-on-a-racecourse-shaped-hole
#11
Benjamin Steven Vien, Louis Raymond Francis Rose, Wing Kong Chiu
Reliable and quantitative non-destructive evaluation for small fatigue cracks, in particular those in hard-to-inspect locations, is a challenging problem. Guided waves are advantageous for structural health monitoring due to their slow geometrical decay of amplitude with propagating distance, which is ideal for rapid wide-area inspection. This paper presents a 3D laser vibrometry experimental and finite element analysis of the interaction between an edge-guided wave and a small through-thickness hidden edge crack on a racecourse shaped hole that occurs, in practice, as a fuel vent hole...
July 1, 2017: Materials
https://www.readbyqxmd.com/read/28772479/swept-mechanism-of-micro-milling-tool-geometry-effect-on-machined-oxygen-free-high-conductivity-copper-ofhc-surface-roughness
#12
Zhenyu Shi, Zhanqiang Liu, Yuchao Li, Yang Qiao
Cutting tool geometry should be very much considered in micro-cutting because it has a significant effect on the topography and accuracy of the machined surface, particularly considering the uncut chip thickness is comparable to the cutting edge radius. The objective of this paper was to clarify the influence of the mechanism of the cutting tool geometry on the surface topography in the micro-milling process. Four different cutting tools including two two-fluted end milling tools with different helix angles of 15° and 30° cutting tools, as well as two three-fluted end milling tools with different helix angles of 15° and 30° were investigated by combining theoretical modeling analysis with experimental research...
January 28, 2017: Materials
https://www.readbyqxmd.com/read/28770984/conductive-polymer-inorganic-hybrid-materials-through-synergistic-mutual-doping-of-the-constituents
#13
Weike Wang, Chaoqiu Chen, Christopher Tollan, Fan Yang, Mikel Beltrán, Yong Qin, Mato Knez
Polymer-matrix-based inorganic-organic hybrid materials are at the cutting edge of current research for their great promise of merging properties of soft and hard solids in one material. Infiltration of polymers with vapors of reactive metal organics is a pathway for postsynthetic blending of the polymer with inorganic materials. Here, we show that this process is also an excellent method for fabricating conductive hybrid materials. Polyaniline (PANI) was infiltrated with ZnO and the initially insulating polymer was converted to a PANI/ZnO hybrid with conductivities as high as 18...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28770387/data-to-decisions-creating-a-culture-of-model-driven-drug-discovery
#14
Frank K Brown, Farida Kopti, Charlie Zhenyu Chang, Scott A Johnson, Meir Glick, Chris L Waller
Merck & Co., Inc., Kenilworth, NJ, USA, is undergoing a transformation in the way that it prosecutes R&D programs. Through the adoption of a "model-driven" culture, enhanced R&D productivity is anticipated, both in the form of decreased attrition at each stage of the process and by providing a rational framework for understanding and learning from the data generated along the way. This new approach focuses on the concept of a "Design Cycle" that makes use of all the data possible, internally and externally, to drive decision-making...
August 2, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28768726/cutting-edge-2b4-mediated-coinhibition-of-cd4-t-cells-underlies-mortality-in-experimental-sepsis
#15
Ching-Wen Chen, Rohit Mittal, Nathan J Klingensmith, Eileen M Burd, Cox Terhorst, Greg S Martin, Craig M Coopersmith, Mandy L Ford
Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memory CD8(+) T cells that has been shown to regulate T cell function in models of viral infection and autoimmunity. In this article, we show that 2B4 signaling mediates sepsis lymphocyte dysfunction and mortality. 2B4 expression is increased on CD4(+) T cells in septic animals and human patients at early time points...
August 2, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28764902/experimental-animal-models-of-parkinson-s-disease-a-transition-from-assessing-symptomatology-to-%C3%AE-synuclein-targeted-disease-modification
#16
REVIEW
Wai Kin D Ko, Erwan Bezard
With the understanding that α-synuclein plays a major role in the pathogenesis of Parkinson's disease (PD), novel animal models have been developed for conducting preclinical research in screening novel disease modifying therapies. Advancements in research techniques in α-synuclein targeted disease modification have utilised methods such as viral mediated expression of human α-synuclein, as well as the inoculation of pathogenic α-synuclein species from Lewy Bodies of PD patients, for accurately modelling progressive self-propagating neurodegeneration...
July 29, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28764221/maximal-aortic-valve-cusp-separation-and-severity-of-aortic-stenosis
#17
K Jayaprakash, V P Dilu, Raju George
INTRODUCTION: An integrated approach that incorporates two dimensional, M mode and Doppler echocardiographic evaluation has become the standard means for accurate quantification of severity of valvular aortic stenosis. Maximal separation of the aortic valve cusps during systole has been shown to correlate well with the severity of aortic stenosis measured by other echocardiographic parameters. AIM: To study the correlation between Maximal Aortic valve Cusp Separation (MACS) and severity of aortic valve stenosis and to find cut-off values of MACS for detecting severe and mild aortic stenosis...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763187/nanoparticle-shape-influences-the-magnetic-response-of-ferro-colloids
#18
Joe G Donaldson, Elena S Pyanzina, Sofia S Kantorovich
The interesting magnetic response of conventional ferrofluids has proved extremely useful in a wide range of technical applications. Furthermore, the use of nano/micro-sized magnetic particles has proliferated cutting-edge medical research, such as drug targeting and hyperthermia. In order to diversify and improve the application of such systems, new avenues of functionality must be explored. Current efforts focus on incorporating directional interactions that are surplus to the intrinsic magnetic one. This additional directionality can be conveniently introduced by considering systems composed of magnetic particles of different shapes...
August 1, 2017: ACS Nano
https://www.readbyqxmd.com/read/28760883/cutting-edge-nkg2d-signaling-enhances-nk-cell-responses-but-alone-is-insufficient-to-drive-expansion-during-mouse-cytomegalovirus-infection
#19
Tsukasa Nabekura, Dagmar Gotthardt, Kouta Niizuma, Tihana Trsan, Tina Jenus, Stipan Jonjic, Lewis L Lanier
NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1(-/-) ) Ly49H(+) NK cells proliferated robustly when infected with MCMV strains engineered to allow expression of NKG2D ligands, which enhanced the response of wild-type NK cells. Naive NK cells exclusively express NKG2D-L, which pairs only with DAP10, whereas NKG2D-S expressed by activated NK cells pairs with DAP10 and DAP12, similar to Ly49H...
July 31, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28760683/functional-morphology-of-hummingbird-bill-tips-their-function-as-tongue-wringers
#20
Alejandro Rico-Guevara, Margaret A Rubega
Nectarivores are animals that have evolved adaptations to efficiently exploit floral nectar as the main source of energy in their diet. It is well known that hummingbirds can extract nectar with impressive speed from flowers. However, despite decades of study on nectar intake rates, the mechanism by which feeding is ultimately achieved - the release of nectar from the tongue so that it can pass into the throat and be ingested - has not been elucidated. By using microCT scanning and macro high-speed videography we scrutinized the morphology and function of hummingbird bill tips, looking for answers about the nectar offloading process...
July 28, 2017: Zoology: Analysis of Complex Systems, ZACS
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