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https://www.readbyqxmd.com/read/28631779/recent-advances-in-nanomedicines-for-the-treatment-of-rheumatoid-arthritis
#1
REVIEW
Qin Wang, Xun Sun
Rheumatoid arthritis (RA) is a severe systemic inflammatory disease. It is often associated with serious cartilage destruction and massive inflammatory infiltration, which might ultimately cause disability, wide complications and reduced life quality. Current clinical treatments of RA show several drawbacks such as high doses, frequent administration and serious side effects. These limitations have motivated tremendous expansion of the research and application of nanomedicines in RA therapy. In this review, we summarize the cutting edge progress in nanomedicines for the treatment of RA and discuss the application of various targeting strategies...
June 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28628043/immunotherapy-for-transplantation-associated-viral-infections
#2
Claire Roddie, Karl S Peggs
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections following allogeneic hematopoietic stem cell transplantation (HSCT) are a major cause of morbidity and mortality. Early clinical trials demonstrate that adoptive transfer of donor-derived virus-specific T cells to restore virus-specific immunity is an effective strategy to control CMV and EBV infection after HSCT, conferring protection in 70%-90% of patients. The field has evolved rapidly to develop solutions to some of the manufacturing challenges identified in early clinical studies, such as prolonged in vitro culture, optimization of the purity of the virus-specific T cell product, the potential limitations of targeting a single viral antigen, and how to manage the patient with a virus-naive donor...
June 19, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28626431/artificial-intelligence-assisted-online-social-therapy-for-youth-mental-health
#3
Simon D'Alfonso, Olga Santesteban-Echarri, Simon Rice, Greg Wadley, Reeva Lederman, Christopher Miles, John Gleeson, Mario Alvarez-Jimenez
Introduction: Benefits from mental health early interventions may not be sustained over time, and longer-term intervention programs may be required to maintain early clinical gains. However, due to the high intensity of face-to-face early intervention treatments, this may not be feasible. Adjunctive internet-based interventions specifically designed for youth may provide a cost-effective and engaging alternative to prevent loss of intervention benefits. However, until now online interventions have relied on human moderators to deliver therapeutic content...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28625826/drug-discovery-and-therapeutic-delivery-for-the-treatment-of-b-and-t-cell-tumors
#4
Regan Stephenson, Ankur Singh
Hematological malignancies manifest as lymphoma, leukemia, and myeloma, and remain a burden on society. From initial therapy to endless relapse-related treatment, societal burden is felt not only in the context of healthcare cost, but also in the compromised quality of life of patients. Long-term therapeutic strategies have become the standard in keeping hematological malignancies at bay as these cancers develop resistance to each round of therapy with time. As a result, there is a continual need for the development of new drugs to combat resistant disease in order to prolong patient life, if not to produce a cure...
June 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28625391/twelve-year-experience-of-radical-but-conservative-liver-surgery-for-colorectal-metastases-impact-on-surgical-practice-and-oncologic-efficacy
#5
Guido Torzilli, Luca Viganò, Andrea Gatti, Guido Costa, Matteo Cimino, Fabio Procopio, Matteo Donadon, Daniele Del Fabbro
BACKGROUND: Liver surgery for colorectal metastases (CLM) is moving toward parenchyma-sparing approaches. The authors reported the technical feasibility of parenchyma-sparing hepatectomy for deeply located tumors, but its impact on daily practice and long-term outcomes remain unclear. METHODS: The patients undergoing liver resection (LR) for CLM with vascular contact (first-/second-order pedicle or hepatic vein (HV) trunk) were considered. Those undergoing major hepatectomy were excluded...
June 16, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28622895/cutting-edge-approaches-to-unwrapping-the-mysteries-of-sleep
#6
EDITORIAL
Yu Hayashi, Shigeyoshi Itohara
No abstract text is available yet for this article.
May 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28622541/transmission-characteristics-of-the-s0-and-a0-lamb-waves-at-contacting-edges-of-plates
#7
Naoki Mori, Shiro Biwa
In order to gain basic insight into the interaction between ultrasonic guided waves and structural discontinuities with contacting surfaces, the transmission characteristics of Lamb waves at contacting edges of two plates are studied experimentally. The edges of two 2.5-mm thick aluminum alloy plates are mated together to constitute a contacting interface of plates and subjected to different levels of compressive loading. The transmission measurements of the lowest-order symmetric (S0) and antisymmetric (A0) Lamb modes across the contacting interface are performed in a frequency range below the cut-off frequencies of the higher-order modes...
June 13, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28617630/the-cutting-edge-of-platelets
#8
Robert K Andrews, Elizabeth E Gardiner
No abstract text is available yet for this article.
June 2017: Platelets
https://www.readbyqxmd.com/read/28615418/cutting-edge-activation-of-sting-in-t-cells-induces-type-i-ifn-responses-and-cell-death
#9
Bridget Larkin, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Edouard Vannier, Alexander Poltorak
Stimulator of interferon genes (STING) was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. In this study, to our knowledge we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways...
June 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28615415/cutting-edge-the-aging-immune-system-reveals-the-biological-impact-of-direct-antigen-presentation-on-cd8-t-cell-responses
#10
Jennifer L Uhrlaub, Megan J Smithey, Janko Nikolich-Žugich
The vertebrate immune system uses multiple, sometimes redundant, mechanisms to contain pathogenic microorganisms that are always evolving to evade host defenses. Thus, the cowpox virus (CPXV) uses genes encoding CPXV12 and CPXV203 to prevent direct MHC class I presentation of viral peptides by infected cells. However, CD8 T cells are effectively primed against CPXV by cross-presentation of viral Ags in young mice. Old mice accumulate defects in both CD8 T cell activation and cross-presentation. Using a double-deletion mutant (∆12∆203) of CPXV, we show that direct priming of CD8 T cells in old mice yields superior recall responses, establishing a key contribution of this mechanism to host antipoxvirus responses and enhancing our fundamental understanding of how viral manipulation of direct presentation impacts pathogenesis...
June 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28615277/alterations-in-the-brain-s-connectome-during-recovery-from-severe-traumatic-brain-injury-protocol-for-a-longitudinal-prospective-study
#11
Virginia Conde, Sara Hesby Andreasen, Tue Hvass Petersen, Karen Busted Larsen, Karine Madsen, Kasper Winther Andersen, Irina Akopian, Kristoffer Hougaard Madsen, Christian Pilebæk Hansen, Ingrid Poulsen, Lars Peter Kammersgaard, Hartwig Roman Siebner
INTRODUCTION: Traumatic brain injury (TBI) is considered one of the most pervasive causes of disability in people under the age of 45. TBI often results in disorders of consciousness, and clinical assessment of the state of consciousness in these patients is challenging due to the lack of behavioural responsiveness. Functional neuroimaging offers a means to assess these patients without the need for behavioural signs, indicating that brain connectivity plays a major role in consciousness emergence and maintenance...
June 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28612705/treatment-of-acetabular-chondral-lesions-with-microfracture-technique
#12
Claudio Mella, Alvaro Nuñez, Ignacio Villalón
INTRODUCTION: Acetabular cartilage lesions are frequently found during hip arthroscopy. In the hip joint they mostly occur secondary to a mechanical overload resulting from a pre-existing deformity as hip dysplasia or femoroacetabular impingement (FAI). Lesions identified during arthroscopy can vary greatly from the earliest stages to the most advanced (full-thickness lesions). These lesions occur in the acetabulum in the early stages of joint damage. Microfractures are indicated in full-thickness chondral defects...
2017: SICOT-J
https://www.readbyqxmd.com/read/28611506/indian-science-culture-needs-a-paradigm-shift
#13
Om P Sharma
There is a general impression in the scientific community in our country that the way science is taught, leant and the work culture of research and management of academic and research institutions is not conducive to cutting edge research, innovation and making world leaders. Mentoring continues to be poor with some exceptions. Very often, senior scientists with long innings in science teaching and research express anguish at the status quo in spite of a number of policy documents and recommendations for change...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28610612/deeper-wedge-resection-and-parenchymal-sparing-bronchoplasty-of-the-secondary-carina-an-alternative-surgical-technique-for-removal-of-tumor-located-at-the-orifice-of-upper-lobar-bronchus
#14
An Wang, Xiaofeng Chen, Dayu Huang, Shaohua Wang
BACKGROUND: Sleeve resection and reconstruction of the bronchial corner between the upper lobar bronchus and the intermediate bronchus is technique demanding. CASE PRESENTATION: A 33-year-old Chinese man suffered from recurrence of low-grade malignant mucoepidermoid carcinoma located at the orifice of upper lobar bronchus with invasion to the main bronchus nearly 1 year after he had undergone an incomplete bronchoscopic resection. With detailed preoperative and intraoperative evaluation by computed tomography and bronchoscopy, a deeper wedge resection and bronchoplasty of the secondary carina was performed...
June 13, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28607112/cutting-edge-active-tgf-%C3%AE-1-released-from-garp-tgf-%C3%AE-1-complexes-on-the-surface-of-stimulated-human-b-lymphocytes-increases-class-switch-recombination-and-production-of-iga
#15
Olivier Dedobbeleer, Julie Stockis, Bas van der Woning, Pierre G Coulie, Sophie Lucas
Production of active TGF-β is regulated at a posttranslational level and implies release of the mature cytokine dimer from the inactive, latent TGF-β precursor. There are several cell-type specific mechanisms of TGF-β activation. We identified a new mechanism operating on the surface of human regulatory T cells and involving membrane protein GARP, which binds latent TGF-β1. The paracrine activity of regulatory T cell-derived TGF-β1 contributes to immunosuppression and can be inhibited with anti-GARP Abs...
June 12, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28606611/bioinfra-prot-a-comprehensive-proteomics-workflow-including-data-standardization-protein-inference-expression-analysis-and-data-publication
#16
Michael Turewicz, Michael Kohl, Maike Ahrens, Gerhard Mayer, Julian Uszkoreit, Wael Naboulsi, Thilo Bracht, Dominik A Megger, Barbara Sitek, Katrin Marcus, Martin Eisenacher
The analysis of high-throughput mass spectrometry-based proteomics data must address the specific challenges of this technology. To this end, the comprehensive proteomics workflow offered by the de.NBI service center BioInfra.Prot provides indispensable components for the computational and statistical analysis of this kind of data. These components include tools and methods for spectrum identification and protein inference, protein quantification, expression analysis as well as data standardization and data publication...
June 9, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28606093/two-steps-forward-one-step-back-current-harm-reduction-policy-and-politics-in-the-united-states
#17
Ethan Nadelmann, Lindsay LaSalle
Harm reduction policies and attitudes in the United States have advanced substantially in recent years but still lag behind more advanced jurisdictions in Europe and elsewhere. The Obama administration, particularly in its last years, embraced some harm reduction policies that had been rejected by previous administrations but shied away from more cutting edge interventions like supervised consumption sites and heroin-assisted treatment. The Trump administration will undermine some of the progress made to date but significant state and local control over drug policies in the US, as well as growing Republican support for pragmatic drug policies, motivated in part by the opioid crisis, ensures continuing progress for harm reduction...
June 12, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28604914/two-deep-ultraviolet-nonlinear-optical-alkaline-earth-metal-borates-based-on-different-types-of-oxoboron-clusters
#18
Qi Wei, Li Sun, Jie Zhang, Guo-Yu Yang
Two non-centrosymmetric alkaline-earth metal borates, Ca2[B5O8(OH)]2[B(OH)3]·H2O (1) and Ba2[B6O9(OH)2][B3O3(OH)4]·(OH)·4H2O (2), have been synthesized under solvothermal conditions. Both of them exhibit layered structures constructed from two fundamental building blocks (FBBs), respectively. 1 features porous double-layers made by the acentric single A-layer and B-layer in a face-to-face arrangement. Ca-O layers gather the B-O double-layers together resulting in the chiral structure of 1. Compound 2 contains two different FBBs, which is rare in borate...
June 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28593837/rhadinorhynchus-oligospinosus-n-sp-acanthocephala-rhadinorhynchidae-from-mackerels-in-the-pacific-ocean-off-peru-and-related-rhadinorhynchids-in-the-pacific-with-notes-on-metal-analysis
#19
Omar M Amin, Richard A Heckmann
Specimens of a new species of Rhadinorhynchus Lühe, 1911 are described from the chub mackerel Scomber japonicus (Scombridae) and the Chilean Jack mackerel Trachurus murphyi (Carangidae) (possibly a subspecies of Trachurus symmetricus) from the Pacific Ocean off the Peruvian coast at the Port of Chicama, La Libertad. Specimens of Rhadinorhynchus oligospinosus n. sp. are somewhat small having 11-14 rows of alternating proboscis hooks with 20-22 hooks each with posteriormost hooks in a continuous ring. Ventral hooks are robust with prominent roots but dorsal hooks are slender and shorter with discoid roots...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28593215/cutting-edge-efforts-in-surgical-patient-safety
#20
Thomas K Varghese, Amir A Ghaferi
No abstract text is available yet for this article.
June 7, 2017: JAMA Surgery
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