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https://www.readbyqxmd.com/read/28239667/disregard-of-neurological-impairments-associated-with-neglected-tropical-diseases-in-africa
#1
Emmanuel Quansah, Esther Sarpong, Thomas K Karikari
Neglected tropical diseases (NTDs) affect people in the bottom billion poorest in the world. These diseases are concentrated in rural areas, conflict zones and urban slums in Africa and other tropical areas. While the World Health Organization recognizes seventeen priority NTDs, the list of conditions present in Africa and elsewhere that are eligible to be classified as NTDs is much longer. Although NTDs are generally marginalized, their associated neurological burden has been almost completely disregarded...
June 2016: ENeurologicalSci
https://www.readbyqxmd.com/read/28238201/advances-in-optogenetic-and-chemogenetic-methods-to-study-brain-circuits-in-non-human-primates
#2
REVIEW
Adriana Galvan, Michael J Caiola, Daniel L Albaugh
Over the last 10 years, the use of opto- and chemogenetics to modulate neuronal activity in research applications has increased exponentially. Both techniques involve the genetic delivery of artificial proteins (opsins or engineered receptors) that are expressed on a selective population of neurons. The firing of these neurons can then be manipulated using light sources (for opsins) or by systemic administration of exogenous compounds (for chemogenetic receptors). Opto- and chemogenetic tools have enabled many important advances in basal ganglia research in rodent models, yet these techniques have faced a slow progress in non-human primate (NHP) research...
February 25, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28231997/retracted-garthe-c-ouellette-l-seamon-jp-et-al-the-virtual-cutting-edge-adolescent-self-injury-and-youtube-ann-emerg-med-2015-66-s145
#3
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28228769/toward-an-evolved-concept-of-landrace
#4
Francesc Casañas, Joan Simó, Joan Casals, Jaime Prohens
The term "landrace" has generally been defined as a cultivated, genetically heterogeneous variety that has evolved in a certain ecogeographical area and is therefore adapted to the edaphic and climatic conditions and to its traditional management and uses. Despite being considered by many to be inalterable, landraces have been and are in a constant state of evolution as a result of natural and artificial selection. Many landraces have disappeared from cultivation but are preserved in gene banks. Using modern selection and breeding technology tools to shape these preserved landraces together with the ones that are still cultivated is a further step in their evolution in order to preserve their agricultural significance...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28227679/wildcard-a-wearable-virtual-reality-storytelling-tool-for-children-with-intellectual-developmental-disability
#5
Mirko Gelsomini, Franca Garzotto, Daniele Montesano, Daniele Occhiuto, Mirko Gelsomini, Franca Garzotto, Daniele Montesano, Daniele Occhiuto, Daniele Montesano, Franca Garzotto, Mirko Gelsomini, Daniele Occhiuto
Our research aims at supporting existing therapies for children with intellectual and developmental disorders (IDD). The personal and social autonomy is the desired end state to be achieved to enable a smooth integration in the real world. We developed and tested a framework for storytelling and learning activities that exploits an immersive virtual reality viewer to interact with target users. We co-designed our system with experts from the medical sector, identifying features that allow patients to stay focused on exercises to perform...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223513/single-neuron-identification-of-chemical-constituents-physiological-changes-and-metabolism-using-mass-spectrometry
#6
Hongying Zhu, Guichang Zou, Ning Wang, Meihui Zhuang, Wei Xiong, Guangming Huang
The use of single-cell assays has emerged as a cutting-edge technique during the past decade. Although single-cell mass spectrometry (MS) has recently achieved remarkable results, deep biological insights have not yet been obtained, probably because of various technical issues, including the unavoidable use of matrices, the inability to maintain cell viability, low throughput because of sample pretreatment, and the lack of recordings of cell physiological activities from the same cell. In this study, we describe a patch clamp/MS-based platform that enables the sensitive, rapid, and in situ chemical profiling of single living neurons...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28223047/diversity-in-sequences-post-translational-modifications-and-expected-pharmacological-activities-of-toxins-from-four-conus-species-revealed-by-the-combination-of-cutting-edge-proteomics-transcriptomics-and-bioinformatics
#7
Michel Degueldre, Marion Verdenaud, Garikoitz Legarda, Rebeca Minambres, Sheila Zuniga, Mathieu Leblanc, Nicolas Gilles, Frederic Ducancel, Edwin De Pauw, Loic Quinton
Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences...
February 18, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28222662/foxf2-promoter-methylation-is-associated-with-prognosis-in-esophageal-squamous-cell-carcinoma
#8
Xiaoying Chen, Haochang Hu, Jing Liu, Yong Yang, Guili Liu, Xiuru Ying, Yingmin Chen, Bin Li, Cong Ye, Dongping Wu, Shiwei Duan
Esophageal squamous cell carcinoma is a commonly malignant tumor of digestive tract with poor prognosis. Previous studies suggested that forkhead box F2 ( FOXF2) could be a candidate gene for assessing and predicting the prognosis of human cancers. However, the relationship between FOXF2 promoter methylation and the prognosis of esophageal squamous cell carcinoma remained unclear. Formalin-fixed, paraffin-embedded esophageal squamous cell carcinoma tissues of 135 esophageal squamous cell carcinoma patients were detected for FOXF2 promoter methylation status by methylation-specific polymerase chain reaction approach...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28222200/understanding-tree-growth-responses-after-partial-cuttings-a-new-approach
#9
Miguel Montoro Girona, Sergio Rossi, Jean-Martin Lussier, Denis Walsh, Hubert Morin
Forest ecosystem management heads towards the use of partial cuttings. However, the wide variation in growth response of residual trees remains unexplained, preventing a suitable prediction of forest productivity. The aim of the study was to assess individual growth and identify the driving factors involved in the responses of residual trees. Six study blocks in even-aged black spruce [Picea mariana (Mill.) B.S.P.] stands of the eastern Canadian boreal forest were submitted to experimental shelterwood and seed-tree treatments...
2017: PloS One
https://www.readbyqxmd.com/read/28217434/gold-nanoparticle-based-platforms-for-circulating-cancer-marker-detection
#10
Xiaohua Huang, Ryan O'Connor, Elyahb Allie Kwizera
Detection of cancer-related circulating biomarkers in body fluids has become a cutting-edge technology that has the potential to noninvasively screen cancer, diagnose cancer at early stage, monitor tumor progression, and evaluate therapy responses. Traditional molecular and cellular detection methods are either insensitive for early cancer intervention or technically costly and complicated making them impractical for typical clinical settings. Due to their exceptional structural and functional properties that are not available from bulk materials or discrete molecules, nanotechnology is opening new horizons for low cost, rapid, highly sensitive, and highly specific detection of circulating cancer markers...
2017: Nanotheranostics (Syd)
https://www.readbyqxmd.com/read/28216560/from-sensor-networks-to-internet-of-things-bluetooth-low-energy-a-standard-for-this-evolution
#11
Diego Hortelano, Teresa Olivares, M Carmen Ruiz, Celia Garrido-Hidalgo, Vicente López
Current sensor networks need to be improved and updated to satisfy new essential requirements of the Internet of Things, where cutting-edge applications will appear. These requirements are: total coverage, zero fails (high performance), scalability and sustainability (hardware and software). We are going to evaluate Bluetooth Low Energy as wireless transmission technology and as the ideal candidate for these improvements, due to its low power consumption, its low cost radio chips and its ability to communicate with users directly, using their smartphones or smartbands...
February 14, 2017: Sensors
https://www.readbyqxmd.com/read/28216472/effects-of-atrial-fibrillation-and-heart-rate-on-percutaneous-mitral-valve-repair-with-mitraclip-results-from-the-transcatheter-mitral-valve-interventions-trami-registry
#12
Alexander Jabs, Ralph S von Bardeleben, Peter Boekstegers, Miriam Puls, Edith Lubos, Raffi Bekeredjian, Taoufik Ouarrak, Björn Plicht, Holger Eggebrecht, Georg Nickenig, Christian Butter, Rainer Hoffmann, Jochen Senges, Ulrich Hink
AIMS: In patients undergoing percutaneous edge-to-edge mitral valve repair for mitral valve regurgitation (MR), our aim was to evaluate acute and follow-up differences with pre-existing sinus rhythm (SR) or atrial fibrillation (AF), as well as comparisons stratified by baseline heart rate. METHODS AND RESULTS: Seven hundred and sixty patients who underwent a MitraClip procedure were prospectively enrolled in the TRAnscatheter Mitral valve Interventions (TRAMI) registry, and stratified according to baseline heart rhythm and heart rate with a cut-off value of 70 beats per minute...
February 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28212290/defining-clinical-response-criteria-and-early-response-criteria-for-precision-oncology-current-state-of-the-art-and-future-perspectives
#13
Vivek Subbiah, Hubert H Chuang, Dhiraj Gambhire, Kalevi Kairemo
In this era of precision oncology, there has been an exponential growth in the armamentarium of genomically targeted therapies and immunotherapies. Evaluating early responses to precision therapy is essential for "go" versus "no go" decisions for these molecularly targeted drugs and agents that arm the immune system. Many different response assessment criteria exist for use in solid tumors and lymphomas. We reviewed the literature using the Medline/PubMed database for keywords "response assessment" and various known response assessment criteria published up to 2016...
February 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/28211699/cycloalkylation-of-c-sp3-h-bond-with-neighboring-carboxylic-acid-as-a-traceless-activating-group
#14
Leiyang Lv, Zhiping Li
Selective functionalization of inert C(sp3)-H bond is one of cutting-edge challenges in chemical synthesis. A novel strategy for selective C(sp3)-H bond cycloalkylation is developed with neighboring carboxylic acid as a traceless activating group. Primary and secondary alkyl carboxylic acids undergo decarboxylation/α-C(sp3)-H cleavage/cycloalkylation to give the five-membered cyclization products, while tertiary acids undergo decarboxylation/β-C(sp3)-H cleavage/cycloalkylation to generate the six-membered cyclization products...
February 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28204883/metabolic-engineering-of-saccharomyces-cerevisiae-for-2-3-butanediol-production
#15
REVIEW
Soo-Jung Kim, Jin-Woo Kim, Ye-Gi Lee, Yong-Cheol Park, Jin-Ho Seo
Saccharomyces cerevisiae is a work horse for production of valuable biofuels and biochemicals including 2,3-butanediol (2,3-BDO), a platform chemical with wide industrial applications for synthetic rubber, biosolvents and food additives. Recently, a cutting-edge technology of metabolic engineering has enabled S. cerevisiae to produce 2,3-BDO with high yield and productivity. These include (i) amplification of the 2,3-BDO biosynthetic pathway, (ii) redirection of carbon flux from ethanol or glycerol toward 2,3-BDO, and (iii) 2,3-BDO production from sugars derived from renewable biomass...
February 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28197569/microfabricated-tools-for-quantitative-plant-biology
#16
Meltem Elitaş, Meral Yüce, Hikmet Budak
The development of microfabricated devices that will provide high-throughput quantitative data and high resolution in a fast, repeatable and reproducible manner is essential for plant biology research. Plants have been intensely explored since the beginning of humanity, especially for medical needs. However, plant biology research is still laborious, lacking the latest technological advancements in the laboratory practices. Microfabricated tools can provide a significant contribution to plant biology research since they require small volumes of samples and reagents with minimal cost and labor...
February 15, 2017: Analyst
https://www.readbyqxmd.com/read/28196217/pathologic-outcomes-of-laparoscopic-vs-open-mesorectal-excision-for-rectal-cancer-a-systematic-review-and-meta-analysis
#17
Aleix Martínez-Pérez, Maria Clotilde Carra, Francesco Brunetti, Nicola de'Angelis
Importance: Rectal resection with mesorectal excision is the mainstay treatment for rectal cancer. Objective: To review and analyze the evidence concerning the pathologic outcomes of laparoscopic (LRR) vs open (ORR) rectal resection for rectal cancer. Data Sources: The Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, Scopus databases, and clinicaltrials.gov were searched for randomized clinical trials (RCTs) comparing LRR vs ORR...
February 8, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28191270/a-close-look-at-the-structure-of-the-tio2-aptes-interface-in-hybrid-nanomaterials-and-its-degradation-pathway-an-experimental-and-theoretical-study
#18
Daniela Meroni, Leonardo Lo Presti, Giovanni Di Liberto, Michele Ceotto, Robert G Acres, Kevin C Prince, Roberto Bellani, Guido Soliveri, Silvia Ardizzone
The surface functionalization of TiO2-based materials with alkylsilanes is attractive in several cutting-edge applications, such as photovoltaics, sensors, and nanocarriers for the controlled release of bioactive molecules. (3-Aminopropyl)triethoxysilane (APTES) is able to self-assemble to form monolayers on TiO2 surfaces, but its adsorption geometry and solar-induced photodegradation pathways are not well understood. We here employ advanced experimental (XPS, NEXAFS, AFM, HR-TEM, and FT-IR) and theoretical (plane-wave DFT) tools to investigate the preferential interaction mode of APTES on anatase TiO2...
January 12, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28188246/cutting-edge-the-transcription-factor-sox2-regulates-aid-expression-in-class-switched-b-cells
#19
Lauren J DiMenna, Wei-Feng Yen, Laura Nicolas, Rahul Sharma, Zara N Saldanha, Jayanta Chaudhuri
IgH class switch recombination (CSR) occurs through the deliberate introduction of activation-induced cytidine deaminase (AID)-instigated DNA double-strand breaks into the IgH loci. Because double-strand breaks are generally highly toxic, mechanisms that regulate AID expression are of much relevance to CSR and genomic integrity; however, effectors of such regulatory processes are still poorly understood. In this article, we show that the transcription factor sex determining region Y-box 2 (Sox2) is expressed in activated B cells, but almost exclusively in those that have undergone CSR...
February 10, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28187722/effectiveness-of-differing-levels-of-support-for-family-meals-on-obesity-prevention-among-head-start-preschoolers-the-simply-dinner-study
#20
Holly E Brophy-Herb, Mildred Horodynski, Dawn Contreras, Jean Kerver, Niko Kaciroti, Mara Stein, Hannah Jong Lee, Brittany Motz, Sheilah Hebert, Erika Prine, Candace Gardiner, Laurie A Van Egeren, Julie C Lumeng
BACKGROUND: Despite slight decreases in obesity prevalence in children, nearly 25% of preschool-aged children are overweight or obese. Most interventions focused on promoting family meals as an obesity-prevention strategy target meal planning skills, knowledge and modeling of healthy eating without addressing the practical resources that enable implementation of family meals. There is a striking lack of evidence about what level of resources low-income parents need to implement family meals...
February 10, 2017: BMC Public Health
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