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https://www.readbyqxmd.com/read/28105559/mature-cystic-teratoma-of-the-ovary-a-cutting-edge-overview-on-imaging-features
#1
REVIEW
Hilal Sahin, Samir Abdullazade, Muzaffer Sanci
Mature cystic teratoma (MCT) is the most common neoplasm of the ovary and includes at least two well- differentiated germ cell layers. Different combinations of mature tissue derivatives with varying arrangements in the tumour cause a wide spectrum of radiological presentation ranging from a purely cystic mass to a complex cystic mass with a considerable solid component. In different imaging modalities, each radiological feature reflects a specific pathologic equivalent that forms because of diverse compositions of histological components...
January 19, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28096075/hpprna-a-snakemake-based-handy-parameter-free-pipeline-for-rna-seq-analysis-of-numerous-samples
#2
Dapeng Wang
RNA-Seq technology has been gradually becoming a routine approach for characterizing the properties of transcriptome in terms of organisms, cell types and conditions and consequently a big burden has been put on the facet of data analysis, which calls for an easy-to-learn workflow to cope with the increased demands from a large number of laboratories across the world. We report a one-in-all solution called hppRNA, composed of four scenarios such as pre-mapping, core-workflow, post-mapping and sequence variation detection, written by a series of individual Perl and R scripts, counting on well-established and preinstalled software, irrespective of single-end or paired-end, unstranded or stranded sequencing method...
January 17, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28093523/cutting-edge-nanog-activates-autophagy-under-hypoxic-stress-by-binding-to-bnip3l-promoter
#3
Meriem Hasmim, Bassam Janji, Mehdi Khaled, Muhammad Zaeem Noman, Fawzia Louache, Didier Bordereaux, Abdou Abderamane, Veronique Baud, Fathia Mami-Chouaib, Salem Chouaib
Hypoxia upregulates the core pluripotency factors NANOG, SOX2, and OCT4, associated with tumor aggressiveness and resistance to conventional anticancer treatments. We have previously reported that hypoxia-induced NANOG contributed in vitro to tumor cell resistance to autologous-specific CTL and in vivo to the in situ recruitment of immune-suppressive cells. In this study, we investigated the mechanisms underlying NANOG-mediated tumor cell resistance to specific lysis under hypoxia. We demonstrated the tumor-promoting effect of hypoxia on tumor initiation into immunodeficient mice using human non-small lung carcinoma cells...
January 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28093522/cutting-edge-human-cd49e-nk-cells-are-tissue-resident-in-the-liver
#4
Han Xian Aw Yeang, Sytse J Piersma, Yiing Lin, Liping Yang, Olga N Malkova, Cathrine Miner, Alexander S Krupnick, William C Chapman, Wayne M Yokoyama
Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e(-) NK cells are tissue resident in the liver...
January 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28092013/sharpening-the-cutting-edge-additional-considerations-for-the-uk-debates-on-embryonic-interventions-for-mitochondrial-diseases
#5
Erica Haimes, Ken Taylor
In October 2015 the UK enacted legislation to permit the clinical use of two cutting edge germline-altering, IVF-based embryonic techniques: pronuclear transfer and maternal spindle transfer (PNT and MST). The aim is to use these techniques to prevent the maternal transmission of serious mitochondrial diseases. Major claims have been made about the quality of the debates that preceded this legislation and the significance of those debates for UK decision-making on other biotechnologies, as well as for other countries considering similar legislation...
December 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28090285/pulmonary-vascular-and-ventricular-dysfunction-in-the-susceptible-patient-2015-grover-conference-series
#6
REVIEW
Bradley A Maron, Roberto F Machado, Larissa Shimoda
Pulmonary blood vessel structure and tone are maintained by a complex interplay between endogenous vasoactive factors and oxygen-sensing intermediaries. Under physiological conditions, these signaling networks function as an adaptive interface between the pulmonary circulation and environmental or acquired perturbations to preserve oxygenation and maintain systemic delivery of oxygen-rich hemoglobin. Chronic exposure to hypoxia, however, triggers a range of pathogenetic mechanisms that include hypoxia-inducible factor 1α (HIF-1α)-dependent upregulation of the vasoconstrictor peptide endothelin 1 in pulmonary endothelial cells...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28088695/deep-metabolome-annotation-in-natural-products-research-towards-a-virtuous-cycle-in-metabolite-identification
#7
REVIEW
Pierre-Marie Allard, Grégory Genta-Jouve, Jean-Luc Wolfender
Natural products (NPs) research is changing and rapidly adopting cutting-edge tools, which radically transform the way to characterize extracts and small molecules. With the innovations in metabolomics, early integration of deep metabolome annotation information allows to efficiently guide the isolation of valuable NPs only and, in parallel, to generate massive metadata sets for the study of given extracts under various perspectives. This is the case for chemotaxonomy studies where common biosynthetic traits among species can be evidenced, but also for drug discovery purpose where such traits, in combination with bioactivity studies on extracts, may evidence bioactive molecules even before their isolation...
January 12, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28069594/sigmod-an-exact-and-efficient-method-to-identify-a-strongly-interconnected-disease-associated-module-in-a-gene-network
#8
Yuanlong Liu, Myriam Brossard, Damian Roqueiro, Patricia Margaritte-Jeannin, Chloé Sarnowski, Emmanuelle Bouzigon, Florence Demenais
MOTIVATION: Apart from single marker-based tests classically used in genome-wide association studies (GWAS), network-assisted analysis has become a promising approach to identify a set of genes associated with disease. To date, most network-assisted methods aim at finding genes connected in a background network, whatever the density or strength of their connections. This can hamper the findings as sparse connections are non-robust against noise from either the GWAS results or the network resource...
January 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28069240/improved-synthesis-of-aluminium-nanoparticles-using-ultrasound-assisted-approach-and-subsequent-dispersion-studies-in-di-octyl-adipate
#9
S Shabana, S H Sonawane, V Ranganathan, P H Pujjalwar, D V Pinjari, B A Bhanvase, P R Gogate, Muthupandian Ashokkumar
The present work reports on an efficient and simple one pot synthetic approach for aluminium nanoflakes and nanoparticles based on the intensification using ultrasound and provides a comparison with the conventional approach to establish the cutting edge process benefits. In situ passivation of aluminium particles with oleic acid was used as the method of synthesis in both the conventional and ultrasound assisted approaches. The aluminium nanoflakes prepared using the ultrasound assisted approach were subsequently dispersed in di-octyl adipate (DOA) and it was demonstrated that a stable dispersion of aluminium nanoflakes into di-octyl adipate (DOA) is achieved...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28060851/molecular-evidence-of-transmission-of-influenza-a-h1n1-2009-on-a-university-campus
#10
Ramandeep Kaur Virk, Vithiagaran Gunalan, Hong Kai Lee, Masafumi Inoue, Catherine Chua, Boon-Huan Tan, Paul Anantharajah Tambyah
BACKGROUND: In the recent years, the data on the molecular epidemiology of influenza viruses have expanded enormously because of the availability of cutting-edge sequencing technologies. However, much of the information is from the temperate regions with few studies from tropical regions such as South-east Asia. Despite the fact that influenza has been known to transmit rapidly within semi-closed communities, such as military camps and educational institutions, data are limited from these communities...
2017: PloS One
https://www.readbyqxmd.com/read/28060245/the-hook-and-release-technique-during-enucleation-surgery
#11
David R Jordan, Bazil Stoica, Jonathan J Dutton
PURPOSE: To describe the results and potential benefit of direct muscle release from the globe during enucleation surgery without identifying sutures in the rectus muscle insertion sites, a technique referred to as the hook and release technique. METHODS: Single center, retrospective chart review of patients who underwent enucleation with direct removal of the rectus muscles without identifying sutures in their insertion sites between January 2011 and September 2015 was carried out...
January 5, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28059420/a-new-view-for-nanoparticle-assemblies-from-crystalline-to-binary-cooperative-complementarity
#12
REVIEW
Cong Yan, Tie Wang
Studies on nanoparticle assemblies and their applications have been research frontiers in nanoscience in the past few decades and remarkable progress has been made in the synthetic strategies and techniques. Recently, the design and fabrication of the nanoparticle-based nanomaterials or nanodevices with integrated and enhanced properties compared to those of the individual components have gradually become the mainstream. However, a systematic solution to provide a big picture for future development and guide the investigation of different aspects of the study of nanoparticle assemblies remains a challenge...
January 6, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28058516/applying-and-advancing-behavior-change-theories-and-techniques-in-the-context-of-a-digital-health-revolution-proposals-for-more-effectively-realizing-untapped-potential
#13
Arlen C Moller, Gina Merchant, David E Conroy, Robert West, Eric Hekler, Kari C Kugler, Susan Michie
As more behavioral health interventions move from traditional to digital platforms, the application of evidence-based theories and techniques may be doubly advantageous. First, it can expedite digital health intervention development, improving efficacy, and increasing reach. Second, moving behavioral health interventions to digital platforms presents researchers with novel (potentially paradigm shifting) opportunities for advancing theories and techniques. In particular, the potential for technology to revolutionize theory refinement is made possible by leveraging the proliferation of "real-time" objective measurement and "big data" commonly generated and stored by digital platforms...
January 5, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28057335/big-data-science-a-literature-review-of-nursing-research-exemplars
#14
Bonnie L Westra, Martha Sylvia, Elizabeth F Weinfurter, Lisiane Pruinelli, Jung In Park, Dianna Dodd, Gail M Keenan, Patricia Senk, Rachel L Richesson, Vicki Baukner, Christopher Cruz, Grace Gao, Luann Whittenburg, Connie W Delaney
BACKGROUND: Big data and cutting-edge analytic methods in nursing research challenge nurse scientists to extend the data sources and analytic methods used for discovering and translating knowledge. PURPOSE: The purpose of this study was to identify, analyze, and synthesize exemplars of big data nursing research applied to practice and disseminated in key nursing informatics, general biomedical informatics, and nursing research journals. METHODS: A literature review of studies published between 2009 and 2015...
December 8, 2016: Nursing Outlook
https://www.readbyqxmd.com/read/28053339/xivth-little-brain-big-brain-next-generation-enteric-neuroscience
#15
Arthur Beyder, Guillaume de Lartigue, Jean-Eric Ghia, Jill M Hoffman
Little Brain Big Brain has been a biannual meeting organized and attended exclusively by young investigators in neurogastroenterology since 1989. The XIVth meeting featured cutting-edge work advancing several novel hypotheses in the main themes of motility, inflammation and metabolism.
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28049889/importance-of-pharmaceutical-training-and-clinical-research-at-medical-facilities
#16
Michiaki Myotoku
 To respond to advancements in medical techniques, and to address the separation of medical and dispensary practices, clinical professors are required to educate human resource staff to become highly-skilled pharmacists. For this purpose, it is extremely important for these professors to learn about cutting-edge practical skills and knowledge, as well as to advance their expertise. In addition, they need to conduct clinical research in cooperation with relevant facilities. As our university does not have its own hospital or pharmacy, it is important to provide training for clinical professors in clinical facilities...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28048504/th-c-204-00-medical-physics-workshop-an-update-on-the-journal-s-improvement-activities-and-guidance-on-writing-and-reviewing-papers
#17
Jeffrey Williamson
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048316/th-c-204-03-writing-good-scientific-papers-and-responding-to-critiques
#18
M Goodsitt
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047733/su-c-brb-07-threshold-driven-optimization-for-reference-based-auto-planning
#19
T Long, M Chen, S Jiang, W Lu
PURPOSE: To study the procedure of reference-based auto-planning for treatment plan optimization and develop a threshold-driven optimization methodology for automatically generating a treatment plan that is motivated by a reference DVH and/or dose distribution. We study threshold-driven optimization for reference-based auto-planning (TORA). METHODS: Commonly used voxel-based quadratic penalties have three components: an overdose weight, and underdose weight, and some target dose threshold...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047511/th-f-209-00-pitfalls-reliability-and-performance-of-diagnostic-x-ray-sources
#20
Rolf Behling
PURPOSE: Performance and reliability of medical X-ray tubes for imaging are crucial from an ethical, clinical and economic perspective. This lecture will deliver insight into the aspects to consider during the decision making process to invest in X-ray imaging equipment. Outdated metric still hampers realistic product comparison. It is time to change this and to comply with latest standards, which consider current technology. Failure modes and ways to avoid down-time of the equipment shall be discussed...
June 2016: Medical Physics
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