Yu-Dun Qu, Zhao-Hua Zhu, Jia-Xuan Li, Wei Zhang, Qi Chen, Chang-Liang Xia, Jun-Nan Ma, Shuan-Ji Ou, Yang Yang, Yong Qi, Chang-Peng Xu
BACKGROUND: The effects on bone mineral density (BMD)/fracture between type 1 (T1D) and type 2 (T2D) diabetes are unknown. Therefore, we aimed to investigate the causal relationship between the two types of diabetes and BMD/fracture using a Mendelian randomization (MR) design. METHODS: A two-sample MR study was conducted to examine the causal relationship between diabetes and BMD/fracture, with three phenotypes (T1D, T2D, and glycosylated hemoglobin [HbA1c]) of diabetes as exposures and five phenotypes (femoral neck BMD [FN-BMD], lumbar spine BMD [LS-BMD], heel-BMD, total body BMD [TB-BMD], and fracture) as outcomes, combining MR-Egger, weighted median, simple mode, and inverse variance weighted (IVW) sensitivity assessments...
April 23, 2024: BMC Musculoskeletal Disorders