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https://www.readbyqxmd.com/read/29602745/implementation-of-a-pharmacist-led-pharmacogenomics-service-for-the-program-of-all-inclusive-care-for-the-elderly-pharm-genome-pace
#1
Kevin T Bain, Emily J Schwartz, Orsula V Knowlton, Calvin H Knowlton, Jacques Turgeon
OBJECTIVES: To determine the feasibility of implementing a pharmacist-led pharmacogenomics (PGx) service for the Program of All-Inclusive Care for the Elderly (PACE). SETTING: A national centralized pharmacy providing PGx services to community-based PACE centers. PRACTICE DESCRIPTION: Individuals 55 years of age and older enrolled in PACE who underwent PGx testing as part of their medical care (n = 296). PRACTICE INNOVATION: Pharmacist-led PGx testing, interpreting, and consulting...
March 27, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29578413/erratum-to-improvement-of-intestinal-absorption-of-curcumin-by-cyclodextrins-and-the-mechanisms-underlying-absorption-enhancement-int-j-pharm-2018-535-340-349
#2
Xinpeng Li, Sachiyo Uehara, Kasirawat Sawangrat, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
No abstract text is available yet for this article.
April 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29545323/erratum-retrospective-evaluation-of-low-ph-viral-inactivation-and-viral-filtration-data-from-a-multiple-company-collaboration
#3
John Mattila, Mike Clark, Shengjiang Liu, John Pieracci, Thomas Gervais, Eileen Wilson, Olga Galperina, Xinfang Li, David Roush, Konstantin Zoeller, Helene Brough, Christelle Simpson-Platre
Ref: Retrospective Evaluation of Low-pH Viral Inactivation and Viral Filtration Data from a Multiple Company Collaboration John Mattila, Mike Clark, Shengjiang Liu, et al. PDA J Pharm Sci and Tech 2016, 70 293-299
Access the most recent version at doi:10.5731/pdajpst.2016.006478 Due to a mathematical error we would like to submit an erratum for figure 6 p298.
March 15, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29531631/a-prototype-for-evidence-based-pharmaceutical-opinions-to-promote-physician-pharmacist-communication-around-deprescribing
#4
Philippe Martin, Cara Tannenbaum
Context: Interprofessional communication is an effective mechanism for reducing inappropriate prescriptions among older adults. Physicians' views about which elements are essential for pharmacists to include in an evidence-based pharmaceutical opinion for deprescribing remain unknown. Objective: To develop a prototype for an evidence-based pharmaceutical opinion that promotes physician-pharmacist communication around deprescribing. Methods: A standardized template for an evidence-based pharmaceutical opinion was developed with input from a convenience sample of 32 primary care physicians and 61 primary care pharmacists, recruited from conferences and community settings in Montreal, Canada...
March 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29524396/cannabis-use-in-individuals-with-spinal-cord-injury-or-moderate-to-severe-traumatic-brain-injury-in-colorado
#5
Lenore Hawley, Jessica M Ketchum, Clare Morey, Kathleen Collins Pharm D, Susan Charlifue
OBJECTIVE: To describe the prevalence of cannabis use in an adult sample with spinal cord injury (SCI) or traumatic brain injury (TBI) in Colorado, and to describe the self-reported reasons and side effects of cannabis use in this sample. DESIGN: Mixed methods observational study, using focus group data and telephone survey SETTING: Community PARTICIPANTS: Colorado adults who have sustained SCI or moderate to severe TBI and have received services through the rehabilitation hospital conducting the study...
March 7, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29513721/assessment-of-the-immunogenicity-of-residual-host-cell-protein-impurities-of-osrhsa
#6
Naghmeh Abiri, Jianlei Pang, Jiquan Ou, Bo Shi, Xianghong Wang, Sucai Zhang, Yunxia Sun, Daichang Yang
Human serum albumin (HSA) is the most abundant protein in human plasma and is widely used at high doses for treating various diseases. Recombinant HSA is an alternative approach to plasma-derived HSA, providing increased safety and an unlimited supply. However, the safety of the residual host cell proteins (HCPs) co-purified with Oryza sativa HSA (OsrHSA) remains to be determined. An animal system was used to assess the immunogenicity of OsrHSA and its residual HCPs. Low immunogenicity and immunotoxicity of the residual HCPs at a dose of 25 μg/kg, equivalent to 25 times the clinical dosage of HSA, were observed...
2018: PloS One
https://www.readbyqxmd.com/read/29512083/imaging-of-microglial-activation-in-alzheimer-s-disease-by-11-c-pbr28-pet
#7
Cornelius K Donat, Nazanin Mirzaei, Sac-Pharm Tang, Paul Edison, Magdalena Sastre
Deficits in neuronal function and synaptic plasticity in Alzheimer's disease (AD) are believed to be linked to microglial activation. A hallmark of reactive microglia is the upregulation of mitochondrial translocator protein (TSPO) expression. Positron emission tomography (PET) is a nuclear imaging technique that measures the distribution of trace doses of radiolabeled compounds in the body over time. PET imaging using the 2nd generation TSPO tracer [11 C]PBR28 provides an opportunity for accurate visualization and quantification of changes in microglial density in transgenic mouse models of Alzheimer's disease (AD)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29501126/corrigendum-to-design-and-validation-of-an-automated-solid-phase-extraction-liquid-chromatography-coupled-mass-spectrometry-method-for-the-quantification-of-propofol-in-plasma-j-pharm-biomed-anal-150-2018-341-346
#8
Felix Maurer, Teodora Shopova, Beate Wolf, Daniel Kiefer, Tobias Hüppe, Thomas Volk, Daniel I Sessler, Sascha Kreuer
No abstract text is available yet for this article.
April 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29499095/retraction
#9
(no author information available yet)
'Influence of genetic variants of IDH1, IDH2, TET2 and DNMT3A on cytarabine cytotoxicity in different populations' by Y. Wang & J. K. Lamba1 The above article from the Journal of Clinical Pharmacy and Therapeutics, published online on 21 November 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted following discussions with the authors, the Journal Editors and John Wiley & Sons Ltd. The Retraction has been agreed as this paper was submitted under the joint names of Yan Wang, Jatinder K...
April 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29494889/improving-reliability-of-chemometric-models-for-authentication-of-species-origin-of-heparin-by-switching-from-1d-to-2d-nmr-experiments
#10
Yulia B Monakhova, Jawed Fareed, Yiming Yao, Bernd W K Diehl
Nuclear magnetic resonance (NMR) spectroscopy is regarded as one of the most powerful and versatile analytical approaches to assure the quality of heparin preparations. In particular, it was recently demonstrated that by using1 H NMR coupled with chemometrics heparin and low molecular weight heparin (LMWH) samples derived from three major animal species (porcine, ovine and bovine) can be differentiated [Y.B. Monakhova et al. J. Pharm. Anal. 149 (2018) 114-119]. In this study, significant improvement of existing chemometric models was achieved by switching to 2D NMR experiments (heteronuclear multiple-quantum correlation (HMQC) and diffusion-ordered spectroscopy (DOSY))...
February 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29485625/datasets2tools-repository-and-search-engine-for-bioinformatics-datasets-tools-and-canned-analyses
#11
Denis Torre, Patrycja Krawczuk, Kathleen M Jagodnik, Alexander Lachmann, Zichen Wang, Lily Wang, Maxim V Kuleshov, Avi Ma'ayan
Biomedical data repositories such as the Gene Expression Omnibus (GEO) enable the search and discovery of relevant biomedical digital data objects. Similarly, resources such as OMICtools, index bioinformatics tools that can extract knowledge from these digital data objects. However, systematic access to pre-generated 'canned' analyses applied by bioinformatics tools to biomedical digital data objects is currently not available. Datasets2Tools is a repository indexing 31,473 canned bioinformatics analyses applied to 6,431 datasets...
February 27, 2018: Scientific Data
https://www.readbyqxmd.com/read/29432681/pharming-for-genes-in-neurotransmission-combining-chemical-and-genetic-approaches-in-c-elegans
#12
Stephen M Blazie, Yishi Jin
Synaptic transmission is central to nervous system function. Chemical and genetic screens are valuable approaches to probe synaptic mechanisms in living animals. The nematode C. elegans is a prime system to apply these methods to discover genes and dissect the cellular pathways underlying neurotransmission. Here, we review key approaches to understand neurotransmission and the action of psychiatric drugs in C. elegans, starting with early studies on cholinergic excitatory signaling at the neuromuscular junction and moving into mechanisms mediated by biogenic amine and psychiatric drugs...
February 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29428216/corrigendum-to-elucidating-the-weak-protein-protein-interaction-mechanisms-behind-the-liquid-liquid-phase-separation-of-a-mab-solution-by-different-types-of-additives-eur-j-pharm-biopharm-120-2017-1-8
#13
Guoliang Wu, Shujing Wang, Zhou Tian, Ning Zhang, Han Sheng, Weiguo Dai, Feng Qian
No abstract text is available yet for this article.
February 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29420694/l1000fwd-fireworks-visualization-of-drug-induced-transcriptomic-signatures
#14
Zichen Wang, Alexander Lachmann, Alexandra B Keenan, Avi Ma'ayan, Oliver Stegle
Motivation: As part of the NIH Library of Integrated Network-based Cellular Signatures (LINCS) program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20,000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less studied potential therapeutic compounds. Results: L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16,000 drug and small-molecule induced gene expression signatures...
February 6, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29411222/physicochemical-characterization-glycosylation-pattern-and-biosimilarity-assessment-of-the-fusion-protein-etanercept
#15
Othman Montacir, Houda Montacir, Andreas Springer, Stephan Hinderlich, Fereidoun Mahboudi, Amirhossein Saadati, Maria Kristina Parr
Etanercept is a soluble fusion protein of the tumor necrosis factor receptor (TNFR) extracellular domain, linked to an Fc part of IgG1. It possesses three N- and 13 O-glycosylation sites. Due to its complex structure, an analytical challenge is facing the development and approval of biosimilars. In the current study, physicochemical characterization using state-of-the-art analytics was performed to analyze intact and subunit masses, post-translational modifications (PTMs), higher order structure and potency of Etanercept originator Enbrel® and its biosimilar Altebrel™ (AryoGen Pharmed) in accordance to critical quality attributes of biopharmaceuticals...
February 6, 2018: Protein Journal
https://www.readbyqxmd.com/read/29395834/corrigendum-to-co-delivery-of-sorafenib-and-sivegf-based-on-mesoporous-silica-nanoparticles-for-asgpr-mediated-targeted-hcc-therapy-eur-j-pharm-sci-111-1-january-2018-492-502
#16
Guirong Zheng, Ruirui Zhao, Aixiao Xu, Zhichun Shen, Xian Chen, Jingwei Shao
No abstract text is available yet for this article.
January 25, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29329769/erratum-to-absorption-liver-first-pass-effect-pharmacokinetics-and-tissue-distribution-of-calycosin-7-o-%C3%A3-d-glucopyranoside-c7g-and-its-major-active-metabolite-calycosin-following-oral-administration-of-c7g-in-rats-by-lc-ms-ms-j-pharm-biomed-anal-148-2018-350
#17
Xiaoting Tian, Shuoji Chen, Yuanyuan Zhang, Luying Chen, Xiaozhen Guo, Zhou Xu, Huan Liu, Pei Hu, Zhenyuan Chen, Zhixiong Li, Chenggang Huang
No abstract text is available yet for this article.
February 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29310708/the-pharms-patient-held-active-record-of-medication-status-feasibility-study-a-research-proposal
#18
Elaine Walsh, Laura J Sahm, Patricia M Kearney, Henry Smithson, David M Kerins, Chrys Ngwa, Ciara Fitzgerald, Stephen Mc Carthy, Eimear Connolly, Kieran Dalton, Derina Byrne, Megan Carey, Colin Bradley
Medication errors are a major source of preventable morbidity, mortality and cost and many occur at the times of hospital admission and discharge. Novel interventions (such as new methods of recording medication information and conducting medication reconciliation) are required to facilitate accurate transfer of medication information. With existing evidence supporting the use of information technology and the patient representing the one constant in the care process, an electronic patient held medication record may provide a solution...
January 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29309155/mutual-impact-of-phase-separation-crystallization-and-water-sorption-in-amorphous-solid-dispersions
#19
Christian Luebbert, Maximilian Wessner, Gabriele Sadowski
The molecular integration of poorly water soluble active pharmaceutical ingredients (APIs) in a suitable polymeric matrix is a possible approach to enhance the dissolution behavior and solubility of these APIs. Like all newly developed pharmaceutical formulations, these formulations (often denoted as amorphous solid dispersions (ASDs)) need to undergo storage stability tests at defined relative humidity (RH) and temperature conditions. In a previous work ( Int. J. Pharm. 2017 ; 532 , 635 - 646 ), it was shown that thermodynamic modeling can be successfully used to predict the long-term stability of ASDs against API crystallization and moisture-induced amorphous-amorphous phase separation (MIAPS)...
February 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29306200/mass-balance-of-emerging-contaminants-in-the-water-cycle-of-a-highly-urbanized-and-industrialized-area-of-italy
#20
Sara Castiglioni, Enrico Davoli, Francesco Riva, Marinella Palmiotto, Paolo Camporini, Angela Manenti, Ettore Zuccato
The occurrence of several classes of emerging contaminants (ECs) was assessed in the River Lambro basin, one of the most urbanized and industrialized areas of Italy. The study aims were to identify the main sources of ECs, quantify their amounts circulating in the water cycle, and study their fate in the aquatic environment. More than 80 ECs were selected among pharmaceuticals (PHARM), personal care products (PCPs), disinfectants (DIS), illicit drugs (IDs), perfluorinated compounds (PERF), alkylphenols and bisphenol A (Alk-BPA), and anthropogenic markers (AM)...
December 22, 2017: Water Research
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