keyword
MENU ▼
Read by QxMD icon Read
search

Pharm

keyword
https://www.readbyqxmd.com/read/29029668/the-de-pharm-project-a-pharmacist-driven-deprescribing-initiative-in-a-nursing-facility
#1
Jennifer Pruskowski, Steven M Handler
OBJECTIVE: Many residents with life-limiting illnesses are being prescribed and taking potentially inappropriate medications (PIMs) and questionably beneficial medications either near or at the end of life. These medications can contribute to adverse drug reactions, increase morbidity, and increase unnecessary burden and cost. It is crucial that the process of deprescribing be incorporated into the care of these residents. After developing a clinical pharmacist-driven deprescribing initiative in the nursing facility, the objective of this project was to reduce the number of PIMs via accepted recommendations from the clinical pharmacist to the primary team...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28991203/pharmacy-practice-and-education-in-the-czech-republic
#2
Petr Nachtigal, Tomáš Šimůnek, Jeffrey Atkinson
The PHARMINE ("Pharmacy Education in Europe") project studied the organisation of pharmacy education, practice and legislation in the European Union (EU) with the objectives of evaluating to what degree harmonisation had taken place with the EU, and producing documents on each individual EU member state. Part of this work was in the form of a survey of pharmacy education, practice, and legislation in the various member states. We will publish the individual member state surveys as reference documents. This paper presents the results of the PHARMINE survey on pharmacy education, training, and practice in the Czech Republic...
October 9, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28985194/current-status-of-blood-pharming-megakaryoctye-transfusions-as-a-source-of-platelets
#3
Kandace Gollomp, Michele P Lambert, Mortimer Poncz
PURPOSE OF REVIEW: Donor-derived platelets have proven to be of hemostatic value in many clinical settings. There is a fear that the need for platelets may outgrow the donor pool in first-world countries. Moreover, there are other challenges with donor platelets that add to the impetus to find an alternative platelet source, especially after the megakaryocyte cytokine thrombopoietin was identified. Megakaryocytes have since been differentiated from numerous cell sources and the observed released platelet-like particles (PLPs) have led to calls to develop such products for clinical use...
November 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28980237/avian-biotechnology
#4
Yoshiaki Nakamura
Primordial germ cells (PGCs) generate new individuals through differentiation, maturation and fertilization. This means that the manipulation of PGCs is directly linked to the manipulation of individuals, making PGCs attractive target cells in the animal biotechnology field. A unique biological property of avian PGCs is that they circulate temporarily in the vasculature during early development, and this allows us to access and manipulate avian germ lines. Following the development of a technique for transplantation, PGCs have become central to avian biotechnology, in contrast to the use of embryo manipulation and subsequent transfer to foster mothers, as in mammalian biotechnology...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28970607/adaptation-and-validation-of-the-fresno-test-of-competence-in-evidence-based-medicine-in-doctor-of-pharmacy-students
#5
Valerie Coppenrath, Lee Anne Filosa, Elizabeth Akselrod, Katherine M Carey
Objective. To adapt and validate an instrument assessing competence in evidence-based medicine (EBM) in Doctor of Pharmacy students. Methods. The Fresno test was validated in medical residents. We adapted it for use in pharmacy students. A total of 120 students and faculty comprised the validation set. Internal reliability, item difficulty, and item discrimination were assessed. Construct validity was assessed by comparing mean total scores of students to faculty, and comparing proportions of students and faculty who passed each item...
August 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28970458/current-status-and-future-suggestions-for-improving-the-pharm-d-curriculum-towards-clinical-pharmacy-practice-in-pakistan
#6
Saima Mahmood Malhi, Hassan Raza, Kiran Ajmal, Sumbul Shamim, Saniya Ata, Salman Farooq, Syed Muhammad Sharib, Sidrat-Ul Muntaha
Objectives & Background: Good curriculum is reflected as the backbone for standard universities to develop competitive professionals having great potential. Pharmacy education in Pakistan has gone through the same developmental stages as in other countries, but is still striving for improvement. In the present study, we want (i) to know the opinion on whether the current pharmacy curriculum requires any improvement in order to meet the training needs of pharmacy professionals regarding clinical knowledge and pharmacy practice; and (ii) to present some humble suggestions to decision-making authorities in order to improve it with respect to patient-focused programs (PFP)...
August 17, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28970446/pharmacy-practice-and-education-in-bulgaria
#7
Valentina Petkova, Jeffrey Atkinson
Pharmacies in Bulgaria have a monopoly on the dispensing of medicinal products that are authorized in the Republic of Bulgaria, as well as medical devices, food additives, cosmetics, and sanitary/hygienic articles. Aptekari (pharmacists) act as responsible pharmacists, pharmacy owners, and managers. They follow a five year Masters of Science in Pharmacy (M.Sc. Pharm.) degree course with a six month traineeship. Pomoshnik-farmacevti (assistant pharmacists) follow a three year degree with a six month traineeship...
June 22, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28969929/ibutilide-effectiveness-and-safety-in-the-cardioversion-of-atrial-fibrillation-and-flutter-in%C3%A2-the-community-emergency-department
#8
David R Vinson, Nelya Lugovskaya, E Margaret Warton, Aaron M Rome, Matthew D Stevenson, Mary E Reed, Manvi R Nagam, Dustin W Ballard
STUDY OBJECTIVE: Little is known about the use of ibutilide for cardioversion in atrial fibrillation and flutter outside of clinical trials. We seek to describe patient characteristics, ibutilide administration patterns, cardioversion rates, and adverse outcomes in the community emergency department (ED) setting. We also evaluate potential predictors of cardioversion success. METHODS: Using a retrospective cohort of adults who received ibutilide in 21 community EDs between January 2009 and June 2015, we gathered demographic and clinical variables from electronic health records and structured manual chart review...
September 29, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28968723/ccfold-rapid-and-accurate-prediction-of-coiled-coil-structures-and-application-to-modeling-intermediate-filaments
#9
Dmytro Guzenko, Sergei V Strelkov
Motivation: Accurate molecular structure of the protein dimer representing the elementary building block of intermediate filaments (IFs) is essential towards the understanding of the filament assembly, rationalizing their mechanical properties and explaining the effect of disease-related IF mutations. The dimer contains a ~300-residue long α-helical coiled coil which cannot be assessed by either direct experimental structure determination or modelling using standard approaches. At the same time, coiled coils are well-represented in structural databases...
September 4, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28952490/photocurable-bioink-for-the-inkjet-3d-pharming-of-hydrophilic-drugs
#10
Giovanny F Acosta-Vélez, Chase S Linsley, Madison C Craig, Benjamin M Wu
Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry...
January 28, 2017: Bioengineering
https://www.readbyqxmd.com/read/28950199/validation-of-a-al-18-f-psma-11-preparation-for-clinical-applications
#11
Ehab Al-Momani, Ina Israel, Samuel Samnick
Imaging prostate-specific membrane antigen (PSMA) using positron emission tomography (PET) has been presented so far as the most sensitive and specific with regard to prostate cancer detection, in particular in high-risk prostate cancer patients. Currently, it mainly features Gallium-68 ((68)Ga) labeled PSMA ligands, notably [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ([(68)Ga]-PSMA-11) and [(68)Ga]DOTAGA-FFK (Sub-KuE termed ([(68)Ga]PSMA-I&T). However, (68)Ga has several shortcomings as radionuclide including a short half-life and non-ideal energies...
September 6, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28941379/corrigendum-to-andrographolide-loaded-nanoparticles-for-brain-delivery-formulation-characterisation-and-in-vitro-permeability-using-hcmec-d3-cell-line-eur-j-pharm-biopharm-119-2017-253-263
#12
Clizia Guccione, Mouhssin Oufir, Vieri Piazzini, Daniela Elisabeth Eigenmann, Evelyn Andrea Jähne, Volha Zabela, Maria Teresa Faleschini, Maria Camilla Bergonzi, Martin Smiesko, Matthias Hamburger, Anna Rita Bilia
No abstract text is available yet for this article.
November 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28889267/inflammatory-activation-of-microglia-and-astrocytes-in-manganese-neurotoxicity
#13
Ronald B Tjalkens, Katriana A Popichak, Kelly A Kirkley
Neurotoxicity due to excessive exposure to manganese (Mn) has been described as early as 1837 (Couper, Br Ann Med Pharm Vital Stat Gen Sci 1:41-42, 1837). Extensive research over the past two decades has revealed that Mn-induced neurological injury involves complex pathophysiological signaling mechanisms between neurons and glial cells. Glial cells are an important target of Mn in the brain, both for sequestration of the metal, as well as for activating inflammatory signaling pathways that damage neurons through overproduction of numerous reactive oxygen and nitrogen species and inflammatory cytokines...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28887366/clearance-prediction-methodology-needs-fundamental-improvement-trends-common-to-rat-and-human-hepatocytes-microsomes-and-implications-for-experimental-methodology
#14
F L Wood, J B Houston, D Hallifax
Although prediction of clearance using hepatocytes and liver microsomes has long played a decisive role in drug discovery, it is widely acknowledged that reliably accurate prediction is not yet achievable despite the predominance of hepatically cleared drugs. Physiologically mechanistic methodology tends to underpredict clearance by several fold, and empirical correction of this bias is confounded by imprecision across drugs. Understanding the causes of prediction uncertainty has been slow, possibly reflecting poor resolution of variables associated with donor source and experimental methods, particularly for the human situation...
November 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28836789/synthesis-of-n-n-dioxopyridazines
#15
Shlomo Rozen, Avshalom Shaffer
Despite many efforts, one of the smallest heterocycles containing two nitrogen atoms, pyridazine, could not be converted to its N,N-dioxide (see, however, Nakadate et al. Chem. Pharm. Bull. 1970 , 18 , 1211 - 1218 ). HOF·CH3CN, made easily from diluted fluorine, was able to accomplish this task in a fast reaction with good yields.
August 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28831398/practice-and-barriers-towards-provision-of-health-promotion-services-among-community-pharmacists-in-gondar-northwest-ethiopia
#16
Dessalegn Asmelashe Gelayee, Gashaw Binega Mekonnen, Seyfe Asrade Atnafe
BACKGROUND: Health promotion is now becoming an integral part of community pharmacy practice worldwide. OBJECTIVES: This study was intended to determine the level of involvement of community pharmacists in providing health promotion service and to identify the barriers to the practice. METHODS: A cross-sectional study was conducted on 48 community pharmacists working in Gondar town, Northwest Ethiopia. Data on sociodemographic factors, practice, and barriers to health promotion service were collected and analyzed using SPSS version 20...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28807819/carrier-characteristics-influence-the-kinetics-of-passive-drug-loading-into-lipid-nanoemulsions
#17
Katrin Göke, Heike Bunjes
Passive loading as a novel screening approach is a material-saving tool for the efficient selection of a suitable colloidal lipid carrier system for poorly water soluble drug candidates. This method comprises incubation of preformed carrier systems with drug powder and subsequent determination of the resulting drug load of the carrier particles after removal of excess drug. For reliable routine use and to obtain meaningful loading results, information on the kinetics of the process is required. Passive loading proceeds via a dissolution-diffusion-based mechanism, where drug surface area and drug water solubility are key parameters for fast passive loading...
August 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28789606/-pharming-out-support-a-promising-approach-to-integrating-clinical-pharmacists-into-established-primary-care-medical-home-practices
#18
Kimberly D Brunisholz, Jeff Olson, Jonathan W Anderson, Emily Hays, Peggy M Tilbury, Bradley Winter, Josh Rickard, Sharon Hamilton, Gregory Parkin
Objective Embedding clinical pharmacists into ambulatory care settings needs to be assessed in the context of established medical home models. Methods A retrospective, observational study examined the effectiveness of the Intermountain Healthcare Collaborative Pharmacist Support Services (CPSS) program from 2012-2015 among adult patients diagnosed with diabetes mellitus (DM) and/or high blood pressure (HBP). Patients who attended this program were considered the intervention (CPSS) cohort. These patients were matched using propensity scores with a reference group (no-CPSS cohort) to determine the effect of achieving disease management goals and time to achievement...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28763236/hinge-deficient-igg1-fc-fusion-application-to-human-lactoferrin
#19
Yuki Shiga, Daisuke Murata, Akinori Sugimoto, Yuta Oshima, Minoru Tada, Akiko Ishii-Watabe, Kenichiro Imai, Kentaro Tomii, Takashi Takeuchi, Shinji Kagaya, Atsushi Sato
Fusion of therapeutic proteins with the antibody Fc domain is a strategy widely applied to increase protein half-life in plasma. In our previous study, we generated a recombinant human lactoferrin (hLF)-immunoglobulin G1 Fc fusion protein (hLF-hinge-CH2-CH3) with improved stability, biological activity, and pharmacokinetics ( Shiga , Y. et al. Eur J Pharm Sci. , 2015 , 67 , 136 - -143 ). However, the Fc domain in fusion proteins can potentially induce antibody-dependent and complement-dependent cytotoxicity and serious side effects...
August 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28761821/pharmacokinetic-parameters-and-over-responsiveness-of-iranian-population-to-propranolol
#20
Ebrahim Salehifar, Shima Ebrahim, Mohammad-Reza Shiran, Fatemeh Faramarzi, Hossein Askari Rad, Razieh Avan, Asadollah Mohseni Kiasari, Pouneh Ebrahimi
Purpose: Propranolol is the most widely used treatment for cardiovascular diseases. Dosage range in our patients is usually less than the amount mentioned in references. The aim of the present study was to clarify whether pharmacokinetic differences are able to justify the need for the fewer doses in our patients or not. Methods: Twenty healthy volunteers (10 male) at heart center of Mazandaran University of Medical Sciences were studied. Samples of blood were collected before a single oral dose (40 mg) of Propranolol...
June 2017: Advanced Pharmaceutical Bulletin
keyword
keyword
13077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"