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https://www.readbyqxmd.com/read/28612023/perception-of-community-pharmacists-towards-dispensing-errors-in-community-pharmacy-setting-in-gondar-town-northwest-ethiopia
#1
Dessalegn Asmelashe Gelayee, Gashaw Binega Mekonnen
BACKGROUND: Dispensing errors are inevitable occurrences in community pharmacies across the world. OBJECTIVE: This study aimed to identify the community pharmacists' perception towards dispensing errors in the community pharmacies in Gondar town, Northwest Ethiopia. METHODS: A cross-sectional study was conducted among 47 community pharmacists selected through convenience sampling. Data were analyzed using SPSS version 20. Descriptive statistics, Mann-Whitney U test, and Pearson's Chi-square test of independence were conducted with P ≤ 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28605194/discovery-of-two-bacterial-nitric-oxide-responsive-proteins-and-their-roles-in-bacterial-biofilm-regulation
#2
Sajjad Hossain, Lisa-Marie Nisbett, Elizabeth M Boon
Bacterial biofilms form when bacteria adhere to a surface and produce an exopolysaccharide matrix ( Costerton Science 1999 , 284 , 1318 ; Davies Science 1998 , 280 , 295 ; Flemming Nat. Rev. Microbiol. 2010 , 8 , 623 ). Because biofilms are resistant to antibiotics, they are problematic in many aspects of human health and welfare, causing, for instance, persistent fouling of medical implants such as catheters and artificial joints ( Brunetto Chimia 2008 , 62 , 249 ). They are responsible for chronic infections in the lungs of cystic fibrosis patients and in open wounds, such as those associated with burns and diabetes...
June 12, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28590834/comparison-of-the-effects-of-a-pharmaceutical-industry-decision-guide-and-decision-aids-on-patient-choice-to-intensify-therapy-in-rheumatoid-arthritis
#3
Richard W Martin, Ryan D Enck, Donald J Tellinghuisen, Aaron T Eggebeen, James D Birmingham, Andrew J Head
OBJECTIVE: To compare the effects a pharmaceutical industry decision guide and International Patient Decision Aids Standard (IPDAS) compliant patient decision aids (PtDA) on patient medication beliefs and choice to intensify therapy. METHODS: Rheumatoid arthritis (RA) patients, who had never taken etanercept (Enbrel), took part in a mail survey. They were presented with a hypothetical decision scenario where they were asked to consider adding etanercept to their current regimen...
July 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28521118/automated-cassette-based-production-of-high-specific-activity-203-212-pb-peptide-based-theranostic-radiopharmaceuticals-for-image-guided-radionuclide-therapy-for-cancer
#4
Mengshi Li, Xiuli Zhang, Thomas P Quinn, Dongyoul Lee, Dijie Liu, Falk Kunkel, Brian E Zimmerman, Daniel McAlister, Keith Olewein, Yusuf Menda, Saed Mirzadeh, Roy Copping, Frances L Johnson, Michael K Schultz
A method for preparation of Pb-212 and Pb-203 labeled chelator-modified peptide-based radiopharmaceuticals for cancer imaging and radionuclide therapy has been developed and adapted for automated clinical production. Pre-concentration and isolation of radioactive Pb2+ from interfering metals in dilute hydrochloric acid was optimized using a commercially-available Pb-specific chromatography resin packed in disposable plastic columns. The pre-concentrated radioactive Pb2+ is eluted in NaOAc buffer directly to the reaction vessel containing chelator-modified peptides...
May 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28507476/effect-of-clopidogrel-on-the-hydroxylation-and-sulfoxidation-of-omeprazole-a-single-dose-study-in-healthy-human-volunteers
#5
Lateef Ahmad, Zafar Iqbal, Shabnam Nazir, Abad Khan, Yasar Shah, Muhammad Imran Khan, Ismail Khan, Amjad Khan
Based upon the known potential interaction between omeprazole (OMP) and clopidogrel (CLOP), the current study was designed to evaluate the effect of CLOP on disposition of OMP and its two major metabolites, 5-hydroxyomeprazole (5-OH-OMP) and omeprazole sulfone (OMP-S) in healthy clinical subjects. A randomized, open label, 2-period, crossover study was designed. Twelve volunteers were selected, of whom eight were extensive metabolizers (EM) of CYP2C19 and 4 were poor metabolizers (PM). They received single dose of OMP either alone or in combination with CLOP (single dose) and samples were collected periodically to calculate various pharmacokinetic parameters...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28472499/a-pharmacy-management-service-for-adults-with-asthma-a-cluster-randomised-controlled-trial
#6
Lai-Yan Wong, Siew-Siang Chua, Abdul-Rahman Husin, Hanisah Arshad
Background.: Although clinical guidelines are available for the management of asthma, this health condition is still poorly managed in many countries. Objectives.: To assess the effects of a Pharmacy Management Service (PharMS) on asthma control of adult patients. Methods.: This study comprised of a cluster randomised controlled trial (RCT) that was conducted from April 2014 to July 2015 at four government health clinics. The control participants received usual pharmacy service, while the intervention participants were recruited into the PharMS...
May 3, 2017: Family Practice
https://www.readbyqxmd.com/read/28471102/cycloplegic-refraction-in-hyperopic-children-effectiveness-of-a-0-5-tropicamide-and-0-5-phenylephrine-addition-to-1-cyclopentolate-regimen
#7
Seul Gi Yoo, Myung Jin Cho, Ungsoo Samuel Kim, Seung Hee Baek
PURPOSE: To evaluate the effectiveness of a cycloplegic regimen using 0.5% tropicamide and 0.5% phenylephrine (Tropherine, Hanmi Pharm), in addition to 1% cyclopentolate, in hyperopic children. METHODS: The medical records of hyperopic patients below the age of 14 years who had undergone cycloplegic retinoscopy were retrospectively reviewed. Cycloplegic refractions were performed using one of two cycloplegic regimens. Regimen 1 was a Tropherine-added regimen comprising the administration of one drop of 1% cyclopentolate followed by two to three drops of Tropherine added at 15-minute intervals...
April 24, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28433183/corrigendum-to-comparative-tissue-distribution-and-excretion-study-of-alkaloids-from-herba-ephedrae-radix-aconiti-lateralis-extracts-in-rats-j-pharm-biomed-anal-134-2017-137-142
#8
Mengyue Ren, Shuai Song, Dedong Liang, Weiting Hou, Xiaomei Tan, Jiabo Luo
No abstract text is available yet for this article.
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28417302/abstracts-pcne-working-conference-2017-bled-slovenia-1-3-february-2017-pharm-care-bled-build-lead-engage-disseminate
#9
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28389352/simple-strategy-to-assess-linezolid-exposure-in-patients-with-multi-drug-resistant-and-extensively-drug-resistant-tuberculosis
#10
Jasper Kamp, Mathieu S Bolhuis, Simon Tiberi, Onno W Akkerman, Rosella Centis, Wiel C de Lange, Jos G Kosterink, Tjip S van der Werf, Giovanni B Migliori, Jan-Willem C Alffenaar
Linezolid is used increasingly for the treatment of multi-drug-resistant (MDR) and extensively-drug-resistant (XDR) tuberculosis (TB). However, linezolid can cause severe adverse events, such as peripheral and optical neuropathy or thrombocytopenia related to higher drug exposure. This study aimed to develop a population pharmacokinetic model to predict the area under the concentration curve (AUC) for linezolid using a limited number of blood samples. Data from patients with MDR-/XDR-TB who received linezolid and therapeutic drug monitoring as part of their TB treatment were used...
June 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28378954/pre-hospital-and-retrieval-medicine-clinical-governance-and-workforce-models
#11
Marcus Kennedy, Mark Elcock, Daniel Ellis, Gary Tall
Pre-hospital and retrieval medicine (PHARM) has developed significantly in the past decade. This perspective article proposes that PHARM should develop with a clear focus on contemporary health governance principles, and that its workforce and models of care adopt modern interdisciplinary approaches. Many of the older systems of managing clinical standards, and outdated cultural approaches to professional 'turf', workforce and scope of practice have little place in high-performance organisations. This paper calls us to attention with a recommendation that best and safest systems of care, structured to optimise patient outcomes and system performance should be our goal...
April 5, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28373464/effects-of-lidocaine-on-ht-29-and-sw480-colon-cancer-cells-in-vitro
#12
Anika C Bundscherer, Manuela Malsy, Diane I Bitzinger, Christoph H R Wiese, Michael A Gruber, Bernhard M Graf
BACKGROUND: Evidence is growing that the risk of cancer dissemination may be enhanced during the perioperative period. Whether particular anesthetic techniques influence oncological outcome is still under discussion. For pain management, lidocaine can be administered perioperatively by intravenous, intraperitoneal or epidural infusion. Here we investigated the effect of lidocaine on colon carcinoma cell lines (HT-29 and SW480) in vitro. MATERIALS AND METHODS: ELISA BrdU (Roche) for cell proliferation and FITC Annexin V detection kit (BD Pharming) for apoptosis analysis were applied...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28285172/multifunctional-luv-liposomes-decorated-for-bbb-and-amyloid-targeting-b-in-vivo-brain-targeting-potential-in-wild-type-and-app-ps1-mice
#13
Konstantina Papadia, Anastasios D Giannou, Eleni Markoutsa, Christian Bigot, Greejte Vanhoute, Spyridon Mourtas, Annemie Van der Linded, Georgios T Stathopoulos, Sophia G Antimisiaris
Multifunctional liposomes (mf-LIPs) having a curcumin-lipid ligand (to target amyloids) together with two ligands to target the transferrin, and the low-density apolipoprotein receptor of the blood-brain-barrier (BBB) on their surface, were previously studied (in vitro) as potential theranostic systems for Alzheimer's disease (AD) (Papadia et al., 2017, Eur. J. Pharm. Sciences; 101:140-148). Herein, the targeting potential of mf-LIPs was compared to that of BBB-LIPs (liposomes having only the two BBB-specific ligands) in FVB mice (normal), as well as in double transgenic mice (APP/PS1) and their corresponding littermates (WT), by live-animal (in vivo) and explanted organ (ex vivo) imaging...
March 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28249713/corrigendum-to-application-of-analytical-quality-by-design-concept-for-bilastine-and-its-degradation-impurities-determination-by-hydrophilic-interaction-liquid-chromatographic-method-j-pharm-biomed-anal-125-2016-385-393
#14
Jelena Terzić, Igor Popović, Anja Tumpa, Ana Stajić, Biljana Jančić-Stojanović
No abstract text is available yet for this article.
February 26, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28239024/in-practical-training-a-questionnaire-survey-and-analysis-to-pharmacy-students-of-the-utilization-situation-of-the-course-contents-of-pharmacy-school
#15
Masato Okubo, Yuka Takahashi, Jun Yamashita, Hideyo Takahashi, Okiko Miyata, Takaaki Suzuki, Itsuko Ishii
  Pharmacy education comprises basic pharmacy (organic chemistry, biochemistry, and physical chemistry) and applied pharmacy (clinical pharmacy, pharm aceutics, and chemical hygiene). Students are expected to apply these subjects studied in pharmacy school during their practical pharmacy training. However, knowledge gained in university does not appear to be fully utilized in practice. We hypothesized that this is due to a lack of connection between pre-practical training education and actual practical training...
February 24, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28236610/zopiclone-use-and-risk-of-fractures-in-older-people-population-based-study
#16
Prasad S Nishtala, Te-Yuan Chyou
OBJECTIVES: The primary objective was to evaluate the risk of fractures associated with use of zopiclone, a new Z-hypnotic, in a population-based cohort of older people in New Zealand (NZ) in a real-world setting. The secondary objective was to examine a nonlinear relationship with age and risk for fractures in zopiclone users. DESIGN: Population-based cohort study with a case-crossover design. SETTING: A nationwide representative sample of New Zealanders aged 65 years and older sourced from the pharmaceutical collections and hospital discharges...
April 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28223877/corrigendum-to-mycosynthesis-of-silver-nanoparticles-bearing-antibacterial-activity-saudi-pharm-j-24-2016-140-146
#17
Pasha Azmath, Syed Baker, Devaraju Rakshith, Sreedharamurthy Satish
[This corrects the article DOI: 10.1016/j.jsps.2015.01.008.].
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28209238/corrigendum-to-the-enhancement-of-gene-silencing-efficiency-with-chitosan-coated-liposome-formulations-of-sirnas-targeting-hif-1%C3%AE-and-vegf-int-j-pharm-478-2015-147-154
#18
Emine Şalva, Suna Özbaş Turan, Fatih Eren, Jülide Akbuğa
No abstract text is available yet for this article.
February 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28152716/documentation-of-pharmacist-provided-patient-education-for-oral-chemotherapy
#19
Neeta K Venepalli, Patrick Joseph Fleming, Christina Haaf, Adam Bursua, Little Irene Park, Sandra Cuellar
237 Background: Pharmacist-provided patient education for oral chemotherapy is poorly documented in patient electronic medical records (EMR) at UIC Oncology Pharmacy. At baseline, 41% of patients who started new therapy with selected oral chemotherapies had a patient education note documented by a pharmacist in their EMR. Our aim is to provide and document patient education for at least 90% of patients who start new oral chemotherapy and fill their prescriptions at UIC Oncology Pharmacy over three months. The importance of patient counseling and documentation is recognized by the Quality Oncology Practice Initiative (QOPI) group...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28130965/corrigendum-to-acid-labile-phpma-modification-of-four-arm-oligoaminoamide-pdna-polyplexes-balances-shielding-and-gene-transfer-activity-in-vitro-and-in-vivo-euro-j-pharm-biopharm-105-2016-85-96
#20
Linda Beckert, Libor Kostka, Eva Kessel, Ana Krhac Levacic, Hana Kostkova, Tomas Etrych, Ulrich Lächelt, Ernst Wagner
No abstract text is available yet for this article.
April 2017: European Journal of Pharmaceutics and Biopharmaceutics
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