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https://www.readbyqxmd.com/read/29432681/pharming-for-genes-in-neurotransmission-combining-chemical-and-genetic-approaches-in-c-elegans
#1
Stephen M Blazie, Yishi Jin
Synaptic transmission is central to nervous system function. Chemical and genetic screens are valuable approaches to probe synaptic mechanisms in living animals. The nematode C. elegans is a prime system to apply these methods to discover genes and dissect the cellular pathways underlying neurotransmission. Here, we review key approaches to understand neurotransmission and the action of psychiatric drugs in C. elegans, starting with early studies on cholinergic excitatory signaling at the neuromuscular junction and moving into mechanisms mediated by biogenic amine and psychiatric drugs...
February 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29428216/corrigendum-to-elucidating-the-weak-protein-protein-interaction-mechanisms-behind-the-liquid-liquid-phase-separation-of-a-mab-solution-by-different-types-of-additives-eur-j-pharm-biopharm-120-2017-1-8
#2
Guoliang Wu, Shujing Wang, Zhou Tian, Ning Zhang, Han Sheng, Weiguo Dai, Feng Qian
No abstract text is available yet for this article.
February 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29420694/l1000fwd-fireworks-visualization-of-drug-induced-transcriptomic-signatures
#3
Zichen Wang, Alexander Lachmann, Alexandra B Keenan, Avi Ma'ayan, Oliver Stegle
Motivation: As part of the NIH Library of Integrated Network-based Cellular Signatures (LINCS) program, hundreds of thousands of transcriptomic signatures were generated with the L1000 technology, profiling the response of human cell lines to over 20,000 small molecule compounds. This effort is a promising approach toward revealing the mechanisms-of-action (MOA) for marketed drugs and other less studied potential therapeutic compounds. Results: L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16,000 drug and small-molecule induced gene expression signatures...
February 6, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29411222/physicochemical-characterization-glycosylation-pattern-and-biosimilarity-assessment-of-the-fusion-protein-etanercept
#4
Othman Montacir, Houda Montacir, Andreas Springer, Stephan Hinderlich, Fereidoun Mahboudi, Amirhossein Saadati, Maria Kristina Parr
Etanercept is a soluble fusion protein of the tumor necrosis factor receptor (TNFR) extracellular domain, linked to an Fc part of IgG1. It possesses three N- and 13 O-glycosylation sites. Due to its complex structure, an analytical challenge is facing the development and approval of biosimilars. In the current study, physicochemical characterization using state-of-the-art analytics was performed to analyze intact and subunit masses, post-translational modifications (PTMs), higher order structure and potency of Etanercept originator Enbrel® and its biosimilar Altebrel™ (AryoGen Pharmed) in accordance to critical quality attributes of biopharmaceuticals...
February 6, 2018: Protein Journal
https://www.readbyqxmd.com/read/29395834/corrigendum-to-co-delivery-of-sorafenib-and-sivegf-based-on-mesoporous-silica-nanoparticles-for-asgpr-mediated-targeted-hcc-therapy-eur-j-pharm-sci-111-1-january-2018-492-502
#5
Guirong Zheng, Ruirui Zhao, Aixiao Xu, Zhichun Shen, Xian Chen, Jingwei Shao
No abstract text is available yet for this article.
January 25, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29329769/erratum-to-absorption-liver-first-pass-effect-pharmacokinetics-and-tissue-distribution-of-calycosin-7-o-%C3%A3-d-glucopyranoside-c7g-and-its-major-active-metabolite-calycosin-following-oral-administration-of-c7g-in-rats-by-lc-ms-ms-j-pharm-biomed-anal-148-2018-350
#6
Xiaoting Tian, Shuoji Chen, Yuanyuan Zhang, Luying Chen, Xiaozhen Guo, Zhou Xu, Huan Liu, Pei Hu, Zhenyuan Chen, Zhixiong Li, Chenggang Huang
No abstract text is available yet for this article.
February 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29310708/the-pharms-patient-held-active-record-of-medication-status-feasibility-study-a-research-proposal
#7
Elaine Walsh, Laura J Sahm, Patricia M Kearney, Henry Smithson, David M Kerins, Chrys Ngwa, Ciara Fitzgerald, Stephen Mc Carthy, Eimear Connolly, Kieran Dalton, Derina Byrne, Megan Carey, Colin Bradley
Medication errors are a major source of preventable morbidity, mortality and cost and many occur at the times of hospital admission and discharge. Novel interventions (such as new methods of recording medication information and conducting medication reconciliation) are required to facilitate accurate transfer of medication information. With existing evidence supporting the use of information technology and the patient representing the one constant in the care process, an electronic patient held medication record may provide a solution...
January 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29309155/mutual-impact-of-phase-separation-crystallization-and-water-sorption-in-amorphous-solid-dispersions
#8
Christian Luebbert, Maximilian Wessner, Gabriele Sadowski
The molecular integration of poorly-water-soluble active pharmaceutical ingredients (APIs) in a suitable polymeric matrix is a possible approach to enhance the dissolution behavior and solubility of these APIs. Like all newly-developed pharmaceutical formulations, these formulations (often denoted as amorphous solid dispersions (ASDs)) need to undergo storage stability tests at defined relative humidity (RH) and temperature conditions. In a previous work (Int. J. Pharm. 532 (2017) 635-646), it was shown that thermodynamic modeling can be successfully used to predict the long-term stability of ASDs against API crystallization and moisture-induced amorphous-amorphous phase separation (MIAPS)...
January 8, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29306200/mass-balance-of-emerging-contaminants-in-the-water-cycle-of-a-highly-urbanized-and-industrialized-area-of-italy
#9
Sara Castiglioni, Enrico Davoli, Francesco Riva, Marinella Palmiotto, Paolo Camporini, Angela Manenti, Ettore Zuccato
The occurrence of several classes of emerging contaminants (ECs) was assessed in the River Lambro basin, one of the most urbanized and industrialized areas of Italy. The study aims were to identify the main sources of ECs, quantify their amounts circulating in the water cycle, and study their fate in the aquatic environment. More than 80 ECs were selected among pharmaceuticals (PHARM), personal care products (PCPs), disinfectants (DIS), illicit drugs (IDs), perfluorinated compounds (PERF), alkylphenols and bisphenol A (Alk-BPA), and anthropogenic markers (AM)...
December 22, 2017: Water Research
https://www.readbyqxmd.com/read/29233408/structured-academic-discussions-through-an-online-education-specific-platform-to-improve-pharm-d-students-learning-outcomes
#10
Srikanth Kolluru, James T Varughese
OBJECTIVE: To facilitate active academic discussions using an online, education-centered platform and reinforce concepts, in order to improve overall course outcomes. MATERIALS AND METHODS: A third year integrated pharmacotherapy course was enrolled on an online searchable platform, Piazza®, to facilitate academic discussions. Students could ask, answer, and explore content, and build on submitted answers in wiki style in collaboration. Instructor posted learning objectives, endorsed student responses with correct answers and led follow-up discussions...
March 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233302/validation-of-a-motivation-survey-tool-for-pharmacy-students-exploring-a-link-to-professional-identity-development
#11
Martina F Mylrea, Tarun Sen Gupta, Beverley D Glass
INTRODUCTION: Self-determination theory (SDT), which describes a continuum of motivation regulators, is proposed as an appropriate framework to study pharmacy student motivation. The aim was to develop a Pharmacy Motivation Scale (Pharm-S) to determine motivation regulators in undergraduate students and explore a possible link to professional identity development. METHODS: The Pharm-S was adapted from the SDT-based, Sports Motivation Scale (SMS-II), and administered to undergraduate students in an Australian pharmacy course...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29222046/erratum-to-ultrasound-mediated-nanoparticle-delivery-across-ex-vivo-bovine-retina-after-intravitreal-injection-eur-j-pharm-biopharm-119-2017-125-136
#12
Di Huang, Ying-Shan Chen, Sachin S Thakur, Ilva D Rupenthal
No abstract text is available yet for this article.
December 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29200459/competency-programming-and-emerging-innovation-in-graduate-education-within-schools-of-pharmacy-the-report-of-the-2016-2017-research-and-graduate-affairs-committee
#13
Samuel M Poloyac, Kirsten F Block, Jane E Cavanaugh, Linda P Dwoskin, Russell B Melchert, Ruth E Nemire, James M O'Donnell, Ronny Priefer, Daniel R Touchette
Graduate education in the pharmaceutical sciences is a cornerstone of research within pharmacy schools. Pharmaceutical scientists are critical contributors to addressing the challenges of new drug discovery, delivery, and optimal care in order to ensure improved therapeutic outcomes in populations of patients. The American Association of Colleges of Pharmacy (AACP) charged the 2016-2017 Research and Graduate Affairs Committee (RGAC) to define the competencies necessary for graduate education in the pharmaceutical sciences (Charge 1), recommend collaborative curricular development across schools of pharmacy (Charge 2), recommend AACP programing for graduate education (Charge 3), and provide guidance on emerging areas for innovation in graduate education (Charge 4)...
October 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29195125/effects-of-continuation-electroconvulsive-therapy-on-quality-of-life-in-elderly-depressed-patients-a-randomized-clinical-trial
#14
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Nagy A Youssef, Laryssa McCloud, Charles H Kellner
We examined whether electroconvulsive therapy (ECT) plus medications ("STABLE + PHARM" group) had superior HRQOL compared with medications alone ("PHARM" group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the "STABLE + PHARM" group versus the "PHARM" group. The overall study design was called "Prolonging Remission in Depressed Elderly" (PRIDE)...
November 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29157801/corrigendum-to-structure-and-pharmaceutical-formulation-development-of-a-new-long-acting-recombinant-human-insulin-analog-studied-by-nmr-and-ms-j-pharm-biomed-anal-135-2017-126-132
#15
Elżbieta Bednarek, Jerzy Sitkowski, Wojciech Bocian, Piotr Borowicz, Grażyna Płucienniczak, Dorota Stadnik, Weronika Surmacz-Chwedoruk, Beata Jaworska, Lech Kozerski
No abstract text is available yet for this article.
January 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29150175/-erratum-to-synthesis-and-binding-affinity-to-human-steroid-hormone-receptors-of-3-phenoxy-4-hydroxycoumarins-and-3-phenoxy-4-phenylcoumarins-ann-pharm-fr-2017-75-455-462
#16
R Bakhchinian, F Bouchoux, S Kirkiacharian
No abstract text is available yet for this article.
November 14, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29144022/collagen-a-review-on-its-sources-and-potential-cosmetic-applications
#17
REVIEW
María Isabela Avila Rodríguez, Laura G Rodríguez Barroso, Mirna Lorena Sánchez
Collagen is a fibrillar protein that conforms the conjunctive and connective tissues in the human body, essentially skin, joints, and bones. This molecule is one of the most abundant in many of the living organisms due to its connective role in biological structures. Due to its abundance, strength and its directly proportional relation with skin aging, collagen has gained great interest in the cosmetic industry. It has been established that the collagen fibers are damaged with the pass of time, losing thickness and strength which has been strongly related with skin aging phenomena [Colágeno para todo...
November 16, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29080846/safety-against-nephrotoxicity-in-paclitaxel-treatment-oral-nanocarrier-as-an-effective-tool-in-preclinical-evaluation-with-marked-in-vivo-antitumor-activity
#18
Hira Choudhury, Bapi Gorain, Rakesh Kumar Tekade, Manisha Pandey, Sanmoy Karmakar, Tapan Kumar Pal
Oral paclitaxel (PTXL) formulations freed from cremophor® EL (CrEL) is always in utmost demand by the cancerous patients due to toxicities associated with the currently marketed formulation. In our previous investigation [Int. J. Pharm. 2014; 460:131], we have developed an oral oil based nanocarrier for the lipophilic drug, PTXL to target bioavailability issue and patient compliance. Here, we report in vivo antitumor activity and 28-day sub-chronic toxicity of the developed PTXL nanoemulsion. It was observed that the apoptotic potential of oral PTXL nanoemulsion significantly inhibited the growth of solid tumor (59...
December 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29079370/impact-of-an-emergency-medicine-pharmacist-on-initial-antibiotic-prophylaxis-for-open-fractures-in-trauma-patients
#19
Somer Harvey, A Brad Hall, Kayla Wilson
BACKGROUND: Targeted antibiotic treatment reduces the infection risk of open fractures when soft tissue and bone are exposed to the environment. The risk of infection increases with higher degrees of injury. The Gustilo-Anderson system was developed to identify the degree of injury of open fractures and can be utilized to guide initial antibiotic therapy. Few studies have been published evaluating the potential impact of emergency medicine pharmacists in trauma, and currently no study has evaluated a pharmacist's influence on antibiotic selection and timing for open fractures...
October 17, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29029668/the-de-pharm-project-a-pharmacist-driven-deprescribing-initiative-in-a-nursing-facility
#20
Jennifer Pruskowski, Steven M Handler
OBJECTIVE: Many residents with life-limiting illnesses are being prescribed and taking potentially inappropriate medications (PIMs) and questionably beneficial medications either near or at the end of life. These medications can contribute to adverse drug reactions, increase morbidity, and increase unnecessary burden and cost. It is crucial that the process of deprescribing be incorporated into the care of these residents. After developing a clinical pharmacist-driven deprescribing initiative in the nursing facility, the objective of this project was to reduce the number of PIMs via accepted recommendations from the clinical pharmacist to the primary team...
August 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
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