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https://www.readbyqxmd.com/read/28333916/genetic-susceptibility-to-bilateral-tinnitus-in-a-swedish-twin-cohort
#1
Iris Lianne Maas, Petra Brüggemann, Teresa Requena, Jan Bulla, Niklas K Edvall, Jacob V B Hjelmborg, Agnieszka J Szczepek, Barbara Canlon, Birgit Mazurek, Jose A Lopez-Escamez, Christopher R Cederroth
PURPOSE: Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR). METHODS: Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures...
March 23, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28326059/unilateral-cochlear-implantation-reduces-tinnitus-loudness-in-bimodal-hearing-a-prospective-study
#2
Jérôme J Servais, Karl Hörmann, Elisabeth Wallhäusser-Franke
Perceptive and receptive aspects of subjective tinnitus like loudness and tinnitus-related distress are partly independent. The high percentage of hearing loss in individuals with tinnitus suggests causality of hearing impairment particularly for the tinnitus percept, leading to the hypothesis that restoration of auditory input has a larger effect on tinnitus loudness than on tinnitus-related distress. Furthermore, it is assumed that high levels of depression or anxiety prevent reductions of tinnitus loudness and distress following restoration of activity in the cochlea...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28323018/modulation-of-auditory-percepts-by-transcutaneous-electrical-stimulation
#3
Margarete Anna Ueberfuhr, Amalia Braun, Lutz Wiegrebe, Benedikt Grothe, Markus Drexl
Transcutaneous, electrical stimulation with electrodes placed on the mastoid processes represents a specific way to elicit vestibular reflexes in humans without active or passive subject movements, for which the term galvanic vestibular stimulation was coined. It has been suggested that galvanic vestibular stimulation mainly affects the vestibular periphery, but whether vestibular hair cells, vestibular afferents, or a combination of both are excited, is still a matter of debate. Galvanic vestibular stimulation has been in use since the late 18(th) century, but despite the long-known and well-documented effects on the vestibular system, reports of the effect of electrical stimulation on the adjacent cochlea or the ascending auditory pathway are surprisingly sparse...
March 17, 2017: Hearing Research
https://www.readbyqxmd.com/read/28316289/post-stapedectomy-granuloma-a-devastating-complication
#4
E Watts, H R F Powell, S R Saeed, R M Irving
OBJECTIVES: This paper reports three cases of severe post-stapedectomy granuloma, emphasising the variable presentation of this devastating complication and the challenges of its management. METHODS: A retrospective review was conducted of three cases of post-stapedectomy granuloma requiring surgical debulking between 2010 and 2015. Clinical symptoms, serial imaging, histopathology and post-operative outcomes were considered. RESULTS: Intra-operatively, extensive granulation tissue with erosion of the otic capsule was found...
March 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28315312/eeg-oscillatory-power-dissociates-between-distress-and-depression-related-psychopathology-in-subjective-tinnitus
#5
Martin Meyer, Patrick Neff, Angelina Grest, Colette Hemsley, Steffi Weidt, Tobias Kleinjung
Recent research has used source estimation approaches to identify spatially distinct neural configurations in individuals with chronic, subjective tinnitus (TI). The results of these studies are often heterogeneous, a fact which may be partly explained by an inherent heterogeneity of/in the TI population and partly by the applied EEG data analysis procedure and EEG hardware. Hence this study was performed to re-enact a formerly published study (Joos et al., 2012) to better understand the reason for differences and overlap between studies from different labs...
March 14, 2017: Brain Research
https://www.readbyqxmd.com/read/28306710/are-intratympanic-corticosteroids-effective-for-m%C3%A3-ni%C3%A3-re%C3%A2-s-disease
#6
Ángela Chuang-Chuang, María A Baeza
Ménière’s disease affects the inner ear and its main symptoms are vertigo, hearing loss and fluctuating aural symptoms. Nowadays, there are many therapeutic alternatives, being the use of intratympanic corticosteroids one that has become popular. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified four systematic reviews including 15 studies overall, of which seven were randomized trials. We extracted data and generated a summary of findings table using the GRADE approach...
March 13, 2017: Medwave
https://www.readbyqxmd.com/read/28306653/new-scoring-system-for-evaluating-patulous-eustachian-tube-patients
#7
Ryoukichi Ikeda, Toshiaki Kikuchi, Hidetoshi Oshima, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi
OBJECTIVE: To assess the efficacy of patulous Eustachian tube handicap inventory (PHI) for patulous Eustachian tube (PET) patients. STUDY DESIGN: Prospective. SETTING: Tertiary referral center. SUBJECTS: A prospective survey of medical records in Sen-En Hospital identified 31 ears of 31 patients with definite PET who received insertion of the silicone plug as surgical treatment group, 29 ears of 29 patients treated with self-instillation of physiological saline solution as conservative treatment group, and 29 ears of 29 patients of sensorineural hearing loss without findings of PET treated between June 2015 and December 2015...
March 16, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28304075/steroid-intracochlear-distribution-differs-by-administration-method-systemic-versus-intratympanic-injection
#8
Jong Joo Lee, Jeong Hun Jang, Oak-Sung Choo, Hye Jin Lim, Yun-Hoon Choung
OBJECTIVE: Steroids have been widely used to treat inner-ear diseases such as sudden sensorineural hearing loss, tinnitus, and Meniere's disease. They can be given via either systemic or intratympanic (IT) injection. The purpose of the present study was to explore differences in intracochlear steroid distribution by the administration method employed (systemic vs. IT injection). STUDY DESIGN: Animal study. METHODS: Twenty-three Sprague-Dawley rats were given fluorescein isothiocyanate-labeled dexamethasone (FITC-DEX) three times (on successive days) via intraperitoneal (IP) or IT injection...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28303087/a-pilot-genome-wide-association-study-identifies-potential-metabolic-pathways-involved-in-tinnitus
#9
Annick Gilles, Guy Van Camp, Paul Van de Heyning, Erik Fransen
Tinnitus, the perception of an auditory phantom sound in the form of ringing, buzzing, roaring, or hissing in the absence of an external sound source, is perceived by ~15% of the population and 2.5% experiences a severely bothersome tinnitus. The contribution of genes on the development of tinnitus is still under debate. The current manuscript reports a pilot Genome Wide Association Study (GWAS) into tinnitus, in a small cohort of 167 independent tinnitus subjects, and 749 non-tinnitus controls, who were collected as part of a cross-sectional study...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28296174/vestibulotoxicity-with-systemic-gentamicin-in-different-dosing-regimens-our-experience-in-46-patients
#10
Mohammed Iqbal Syed, Jerome A Leis, Ophir Ilan, Wayne L Gold, David D Pothier, John A Rutka
Although the use of topical gentamicin has declined systemic gentamicin remains an important antimicrobial agent in the management of infections caused by multidrug-resistant gram-negative bacteria. Nephrotoxicity and Ototoxicity from systemic gentamicin is well documented despite normal gentamicin levels (peak and trough) and normal renal function tests Nephrotoxicity is a predisposing factor for vestibulotoxicity however vestibulotoxicity can still occur, in patients without nephrotoxicity [19 of 46 (43.1%) % in our series] much more significantly in single daily dosing (SDD) compared to multiple daily dosing (MDD) From our database of 46 patients we analyzed 19 patients with vestibulotoxicity without nephrotoxicity...
March 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28294697/efficacy-of-low-level-laser-therapy-in-subjective-tinnitus-patients-with-temporomandibular-disorders
#11
Nermin Demirkol, Aslihan Usumez, Mehmet Demirkol, Fatih Sari, Cihan Akcaboy
OBJECTIVE AND BACKGROUND: Tinnitus is an apparent sound, perceived in the ear with no stimulus. It has been described as a sound originating from the brain. It affects 17% of the general population. Etiological factors for tinnitus include temporomandibular joint disorders (TMJ, TMD) and Costen's syndrome. The aim of treatment is to eliminate the tinnitus or at least decrease its apparent volume. MATERIALS AND METHODS: In total, 46 patients referred to our department with bilateral subjective tinnitus with TMDs were selected for this study...
March 14, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28286637/a-retrospective-study-of-the-clinical-characteristics-and-post-treatment-hearing-outcome-in-idiopathic-sudden-sensorineural-hearing-loss
#12
Purushothaman Ganesan, Purushothaman Pavanjur Kothandaraman, Simham Swapna, Vinaya Manchaiah
The purpose of this retrospective study was to analyze the clinical characteristics and document hearing recovery in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). 122 patients diagnosed with unilateral ISSNHL, from March 2009 to December 2014, were treated with oral steroids and pentoxifylline. Hearing change was evaluated by comparing pre-treatment and post-treatment pure-tone average (PTA) (500, 1K, and 2K Hz), and categorized into complete, partial, and no recovery of hearing. T-test, Wilcoxon Signed Rank test and Regression analysis were employed to analyze the statistical significance...
February 1, 2017: Audiology Research
https://www.readbyqxmd.com/read/28286364/considerations-in-the-development-of-a-sound-tolerance-interview-and-questionnaire-instrument
#13
REVIEW
LaGuinn P Sherlock, Craig Formby
Most clinicians approach the objective fitting of hearing aids with three goals in mind: audibility, comfort, and tolerance. When these three amplification goals have been met, the hearing aid user is more likely to adapt to and perceive benefit from hearing aid use. However, problems related to the loudness of sounds and reduced sound tolerance, which may or may not be reported by the aided user, can adversely impact adaptation to amplification and the individual's quality of life. Although there are several standardized questionnaires available to evaluate hearing aid benefit and satisfaction, there is no standardized questionnaire or interview tool for evaluating reduced sound tolerance and the related impact on hearing aid use...
February 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/28286241/prognostic-indicators-for-decrease-in-tinnitus-severity-after-cervical-physical-therapy-in-patients-with-cervicogenic-somatic-tinnitus
#14
S Michiels, P Van de Heyning, S Truijen, A Hallemans, W De Hertogh
BACKGROUND: Tinnitus can be related to many different aetiologies such as hearing loss or a noise trauma, but it can also be related to the somatosensory system of the cervical spine, called cervicogenic somatic tinnitus(CST). Recently, a positive effect of multi-modal cervical physical therapy on tinnitus severity in patients with CST was demonstrated. To date however, the outcome of the intervention cannot be predicted. OBJECTIVE: To identify prognostic indicators for decrease in tinnitus severity after cervical physical therapy in patients with CST...
March 6, 2017: Musculoskelet Sci Pract
https://www.readbyqxmd.com/read/28286233/speech-intelligibility-and-subjective-benefit-in-single-sided-deaf-adults-after-cochlear-implantation
#15
Mareike Finke, Angelika Strauß-Schier, Eugen Kludt, Andreas Büchner, Angelika Illg
Treatment with cochlear implants (CIs) in single-sided deaf individuals started less than a decade ago. CIs can successfully reduce incapacitating tinnitus on the deaf ear and allow, so some extent, the restoration of binaural hearing. Until now, systematic evaluations of subjective CI benefit in post-lingually single-sided deaf individuals and analyses of speech intelligibility outcome for the CI in isolation have been lacking. For the prospective part of this study, the Bern Benefit in Single-Sided Deafness Questionnaire (BBSS) was administered to 48 single-sided deaf CI users to evaluate the subjectively perceived CI benefit across different listening situations...
March 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28286100/the-gap-prepulse-inhibition-deficit-of-the-cortical-n1-p2-complex-in-patients-with-tinnitus-the-effect-of-gap-duration
#16
Yunseo Ku, Joong Woo Ahn, Chiheon Kwon, Do Youn Kim, Myung-Whan Suh, Moo Kyun Park, Jun Ho Lee, Seung Ha Oh, Hee Chan Kim
The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing loss-matched controls without tinnitus. The inhibition degrees of the N1-P2 complex were assessed at 100-, 50-, and 20-ms gap durations with tinnitus-pitch-matched and non-matched frequency background noises...
March 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28286099/tinnitus-and-hyperacusis-contributions-of-paraflocculus-reticular-formation-and-stress
#17
Yu-Chen Chen, Guang-Di Chen, Ben Auerbach, Senthilvelan Manohar, Kelly Radziwon, Richard Salvi
Tinnitus and hyperacusis are common and potentially serious hearing disorders associated with noise-, age- or drug-induced hearing loss. Accumulating evidence suggests that tinnitus and hyperacusis are linked to excessive neural activity in a distributed brain network that not only includes the central auditory pathway, but also brain regions involved in arousal, emotion, stress and motor control. Here we examine electrophysiological changes in two novel non-auditory areas implicated in tinnitus and hyperacusis: the caudal pontine reticular nucleus (PnC), involved in arousal, and the paraflocculus lobe of the cerebellum (PFL), implicated in head-eye coordination and gating tinnitus and we measure the changes in corticosterone stress hormone levels...
March 7, 2017: Hearing Research
https://www.readbyqxmd.com/read/28284967/etiology-treatment-modalities-of-occipital-artery-aneurysms
#18
Nauman S Chaudhry, Brandon G Gaynor, Shahrose Hussain, Paul D Dernbach, Mohammad A Aziz-Sultan
BACKGROUND: Aneurysms of the external carotid artery represent approximately 2% of cervical carotid aneurysms with the majority being traumatic pseudoaneurysms. The diagnosis, treatment, and follow-up of such lesions are completely individualized as there is a paucity of literature available for guidance. CASE DESCRIPTION: We report the case of an 83-year-old woman with an 8-week history of headache in the occipital region, transient episode of gait disturbance, and pulsatile tinnitus on the right...
March 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28282709/analysis-of-saccular-function-with-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#19
Sasan Dabiri, Nasrin Yazdani, Mahdis Esfahani, Niloufar Tari, Susan Adil, Zahra Mahvi, Nima Rezazadeh
Meniere's disease is the disorder of inner ear characterized by vertigo, tinnitus and sensorineural hearing loss. The vestibular evoked myogenic potential (VEMP) test could be useful in the analysis of saccular function, and diagnosis of Meniere's disease. In this study, we've analyzed the saccular function, using VEMP test in different groups of Meniere's disease. Patients were categorized as possible, probable or definite Meniere's disease groups according to the guideline of American Academy of Otolaryngology-Head and Neck Surgery...
February 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282482/the-effect-of-tinnitus-on-listening-effort-in-normal-hearing-young-adults-a-preliminary-study
#20
Sofie Degeest, Hannah Keppler, Paul Corthals
Purpose: The objective of this study was to investigate the effect of chronic tinnitus on listening effort. Method: Thirteen normal-hearing young adults with chronic tinnitus were matched with a control group for age, gender, hearing thresholds, and educational level. A dual-task paradigm was used to evaluate listening effort in different listening conditions. A primary speech-recognition task and a secondary memory task were performed both separately and simultaneously...
March 10, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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