keyword
MENU ▼
Read by QxMD icon Read
search

Varghese

keyword
https://www.readbyqxmd.com/read/29161500/a-small-molecule-mimetic-of-the-humanin-peptide-as-a-candidate-for-modulating-nmda-induced-neurotoxicity
#1
Mohammad Parvez Alam, Tina Bilousova, Patricia Spilman, Kanagasabai Vadivel, Dongsheng Bai, Denis Evseenko, Varghese John
Humanin (HN), a 24-amino acid bioactive peptide, has been shown to increase cell survival of neurons after exposure to Aβ and NMDA-induced toxicity and thus could be beneficial in the treatment of Alzheimer's disease (AD). The neuroprotection by HN is reported to be primarily through its agonist binding properties to the gp130 receptor. However, peptidic nature of HN presents challenges in its development as a therapeutic for AD. We report here for the first time the elucidation of the binding site of Humanin (HN) peptide to gp130 receptor extracellular domain through modeling and the synthesis of small molecule mimetics that interact with the HN binding site on the gp130 receptor that provides protection against NMDA-induced neurotoxicity in primary hippocampal neurons...
November 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29156888/chimeric-antigen-receptor-car-t-and-other-t-cell-strategies-for-pancreas-adenocarcinoma
#2
Anna M Varghese
Treatments in metastatic pancreas cancer remain based in cytotoxic chemotherapy, and novel treatment strategies are needed. Building on the emerging role of T cell therapy in hematologic malignancies and our understanding of the underlying biology of pancreas cancer, research is growing in the role of T cell therapy for patients with solid tumors in general and more specifically patients with pancreas cancer. This review will focus on describing the biology of T cell therapy and its current applications in pancreas cancer...
October 24, 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29153770/rats-exposed-to-2-45ghz-of-non-ionizing-radiation-exhibit-behavioral-changes-with-increased-brain-expression-of-apoptotic-caspase-3
#3
Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit Shukla
In recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4GHz frequency. The present study evaluated the impact of 2.45GHz radiation exposure for 4h/day for 45days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homogenates after sacrificing the rats on day 45. In morris water maze, elevated plus maze and light dark box test, the 2...
November 14, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29147115/effects-of-aminoglycoside-antibiotics-on-human-embryonic-stem-cell-viability-during-differentiation-in-vitro
#4
Divya S Varghese, Shama Parween, Mustafa T Ardah, Bright Starling Emerald, Suraiya A Ansari
Human embryonic stem cells (hESCs) are being used extensively in array of studies to understand different mechanisms such as early human embryogenesis, drug toxicity testing, disease modeling, and cell replacement therapy. The protocols for the directed differentiation of hESCs towards specific cell types often require long-term cell cultures. To avoid bacterial contamination, these protocols include addition of antibiotics such as pen-strep and gentamicin. Although aminoglycosides, streptomycin, and gentamicin have been shown to cause cytotoxicity in various animal models, the effect of these antibiotics on hESCs is not clear...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29146876/organizational-update-world-health-organization
#5
Cherian Varghese, Oyere Onuma, Walter Johnson, Michael Brainin, Werner Hacke, Bo Norrving
No abstract text is available yet for this article.
November 16, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29142381/nursing-management-of-adults-with-severe-traumatic-brain-injury-a-narrative-review
#6
REVIEW
Roseminu Varghese, Jyothi Chakrabarty, Girish Menon
Effective nursing management strategies for adults with severe traumatic brain injury (STBI) are still a remarkable issue and a difficult task for neurologists, neurosurgeons, and neuronurses. A list of justified indications and scientific rationale for nursing management of these patients are continuously evolving. The objectives of the study are to analyze the pertinently available research and clinical studies that demonstrate the nursing management strategies for adults with STBI and to synthesize the available evidence based on the review...
October 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29141755/case-report-failure-of-therapeutic-coma-in-rabies-encephalitis
#7
Abi Manesh, Reeta Subramaniam Mani, Kishore Pichamuthu, Manjeera Jagannati, Vivek Mathew, Rajiv Karthik, Ooriapadickal Cherian Abraham, Geeta Chacko, George M Varghese
Rabies encephalitis is a fulminant, almost universally fatal infection involving the central nervous system. A unique treatment protocol, including anti-exicitotoxic therapy and induced coma was credited with the survival of a vaccinated teenager with bat rabies encephalitis in 2005. However, multiple efforts to replicate this expensive and intense protocol have not been successful. In this article, we report the failure of the protocol in Indian patients with canine-acquired rabies and elucidate the potential explanations for the failure of the protocol in our patients...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29132521/gallbladder-dysfunction-cholecystitis-choledocholithiasis-cholangitis-and-biliary-dyskinesia
#8
REVIEW
Thad Wilkins, Edward Agabin, Jason Varghese, Asif Talukder
The prevalence of gallstones is 10% to 15% in adults. Individuals with acute cholecystitis present with right upper quadrant pain, fever, and leukocytosis. Management includes supportive care and cholecystectomy. The prevalence of choledocholithiasis is 10% to 20%, and serious complications include cholangitis and gallstone pancreatitis. The goal of management in individuals with choledocholithiasis consists of clearing common bile duct stones. Acute ascending cholangitis is a life-threatening condition involving acute inflammation and infection of the common bile duct...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29131227/controlling-electron-and-energy-transfer-paths-by-selective-excitation-in-a-zinc-porphyrin-bodipy-c60-multi-modular-triad
#9
Christopher O Obondi, Gary N Lim, Priscilla Martinez, Varghese Swamy, Francis D'Souza
A multi-modular donor-acceptor triad composed of zinc porphyrin, BF2-chelated dipyrromethene (BODIPY), and C60 was newly synthesized, with the BODIPY entity at the central position. Using absorbance and emission spectral, electrochemical redox, and computational optimization results, energy level diagrams for the ZnP-BODIPY dyad and ZnP-BODIPY-C60 triad were constructed to envision the different photochemical events upon selective excitation of the BODIPY and ZnP entities. By transient absorption spectral studies covering a wide femtosecond-to-millisecond time scale, evidence for the different photochemical events and their kinetic information was secured...
November 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/29126197/impaired-insulin-action-is-associated-with-increased-glucagon-concentrations-in-non-diabetic-humans
#10
Anu Sharma, Ron T Varghese, Meera Shah, Chiara Dalla Man, Claudio Cobelli, Robert A Rizza, Kent R Bailey, Adrian Vella
Context: Abnormal glucagon concentrations contribute to hyperglycemia but the mechanism(s) of α-cell dysfunction in prediabetes are unclear. Objective: We sought to determine the relative contributions of insulin secretion and action to α-cell dysfunction in non-diabetic subjects across the spectrum of glucose tolerance. Design: This was a cross-sectional study. A subset of subjects (n = 120) was studied in the presence and absence of free fatty acid (FFA) elevation, achieved by infusion of intralipid + heparin, to cause insulin resistance...
November 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29121971/cmr-based-blood-oximetry-via-multi-parametric-estimation-using-multiple-t2-measurements
#11
Juliet Varghese, Lee C Potter, Richard LaFountain, Xueliang Pan, Subha V Raman, Rizwan Ahmad, Orlando P Simonetti
BACKGROUND: Measurement of blood oxygen saturation (O2 saturation) is of great importance for evaluation of patients with many cardiovascular diseases, but currently there are no established non-invasive methods to measure blood O2 saturation in the heart. While T2-based CMR oximetry methods have been previously described, these approaches rely on technique-specific calibration factors that may not generalize across patient populations and are impractical to obtain in individual patients...
November 9, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29118473/validating-micronucleus-score-in-effusion-fluids
#12
Nidhya Ganesan, Manjiri D Phansalkar, Marie M Ambroise, Renu G Varghese
Background: Identifying malignant cells in effusion fluid is vital in staging and management of cancers. Differentiating reactive mesothelial cells from malignant cells in effusion fluid is a challenging task and there is an ongoing need for simpler and cost effective tool to aid the diagnosis. Micronucleus is an additional smaller nucleus in the cytoplasm, formed by chromosomes or chromosomal fragments formed during cell division. Aims: The aim of this study was to assess the significance of micronucleated cell in effusion fluids to distinguish adenocarcinomatous from reactive mesothelial effusions...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29107828/perturbation-evoked-potentials-significance-and-application-in-balance-control-research
#13
REVIEW
Jessy Parokaran Varghese, Robert E McIlroy, Michael Barnett-Cowan
Historically, balance control was thought to be mediated solely by subcortical structures based on animal research. However, recent findings provide compelling evidence of cortical involvement during balance reactions evoked by whole-body postural perturbations. In humans, an external perturbation elicits an evoked potential, termed the perturbation-evoked potential (PEP). PEPs are widely distributed over fronto-centro-parietal areas with maximal amplitude at the FCz/Cz electrode. From our literature review it is evident that the PEPs are comprised of a small positive potential (P1) that peaks around 30-90ms after perturbation onset, a large negative potential (N1) that peaks around 90-160ms, followed by positive (P2) and negative (N2) potentials between 200 and 400ms...
October 28, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29106886/surgical-treatment-for-early-small-cell-lung-cancer-variability-in-practice-and-impact-on-survival
#14
Elliot Wakeam, James P Byrne, Gail E Darling, Thomas K Varghese
BACKGROUND: Surgical resection with lobectomy is recommended for T1/T2 N0 small cell lung cancer (SCLC) patients after negative mediastinal staging. We sought to characterize variation in surgical therapy for early SCLC and determine the effect of a hospital's practice patterns on patient survival. METHODS: The National Cancer Database was examined from 2004 to 2013. Risk- and reliability-adjusted hierarchical logistic regression was used to estimate the adjusted odds of resection by hospital...
October 26, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29102370/characteristics-of-postoperative-weight-bearing-and-management-protocols-for-tibial-plateau-fractures-findings-from-a-scoping-review
#15
REVIEW
John B Arnold, Chen Gang Tu, Tri M Phan, Mark Rickman, Viju Daniel Varghese, Dominic Thewlis, Lucian B Solomon
OBJECTIVE: To identify and describe the characteristics of existing practices for postoperative weight bearing and management of tibial plateau fractures (TPFs), identify gaps in the literature, and inform the design of future research. METHODS: Seven electronic databases and clinical trial registers were searched from inception until November 17th 2016. Studies were included if they reported on the surgical management of TPFs, had a mean follow-up time of ≥1year and provided data on postoperative management protocols...
October 31, 2017: Injury
https://www.readbyqxmd.com/read/29096387/clinical-and-neuropsychological-profile-of-persons-with-mild-cognitive-impairment-a-hospital-based-study-from-a-lower-and-middle-income-country
#16
Srikala Bharath, Shilpa Sadanand, Keshav J Kumar, Rakesh Balachandar, Himanshu Joshi, Mathew Varghese
Mild Cognitive impairment (MCI) is an important pre-dementia stage to be identified towards prevention. We screened a large number of older adults seeking help at hospital and community towards a diagnosis of MCI and this study describe their clinical and neuropsychological profile. Older adults aged 60 years & above seeking help at NIMHANS outpatient & community services were screened for early cognitive deficits. Persons were diagnosed to have MCI according to Petersen's criteria, after detailed clinical and neuropsychological assessments...
October 16, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29096039/diagnosis-of-lethal-or-prenatal-onset-autosomal-recessive-disorders-by-parental-exome-sequencing
#17
Karen L Stals, Matthew Wakeling, Júlia Baptista, Richard Caswell, Andrew Parrish, Julia Rankin, Carolyn Tysoe, Garan Jones, Adam C Gunning, Hana Lango-Allen, Lisa Bradley, Angela F Brady, Helena Carley, Jenny Carmichael, Bruce Castle, Deirdre Cilliers, Helen Cox, Charu Deshpande, Abhijit Dixit, Jacqueline Eason, Frances Elmslie, Andrew E Fry, Alan Fryer, Muriel Holder, Tessa Homfray, Emma Kivuva, Victoria McKay, Ruth Newbury-Ecob, Michael Parker, Ravi Savarirayan, Claire Searle, Nora Shannon, Deborah Shears, Sarah Smithson, Ellen Thomas, Peter D Turnpenny, Vinod Varghese, Pradeep Vasudevan, Emma Wakeling, Emma L Baple, Sian Ellard
OBJECTIVE: Rare genetic disorders resulting in prenatal or neonatal death are genetically heterogeneous but testing is often limited by the availability of fetal DNA, leaving couples without a potential prenatal test for future pregnancies. We describe our novel strategy of exome sequencing parental DNA samples to diagnose recessive monogenic disorders in an audit of the first 50 couples referred. METHOD: Exome sequencing was carried out in a consecutive series of 50 couples who had one or more pregnancies affected with a lethal or prenatal-onset disorder...
November 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29093768/draft-genome-sequence-of-marinobacterium-rhizophilum-cl-yj9-t-dsm-18822-t-isolated-from-the-rhizosphere-of-the-coastal-tidal-flat-plant-suaeda-japonica
#18
Dong Han Choi, Gwang Ii Jang, Alla Lapidus, Alex Copeland, T B K Reddy, Supratim Mukherjee, Marcel Huntemann, Neha Varghese, Natalia Ivanova, Manoj Pillay, Brian J Tindall, Markus Göker, Tanja Woyke, Hans-Peter Klenk, Nikos C Kyrpides, Byung Cheol Cho
The genus Marinobacterium belongs to the family Alteromonadaceae within the class Gammaproteobacteria and was reported in 1997. Currently the genus Marinobacterium contains 16 species. Marinobacterium rhizophilum CL-YJ9(T) was isolated from sediment associated with the roots of a plant growing in a tidal flat of Youngjong Island, Korea. The genome of the strain CL-YJ9(T) was sequenced through the Genomic Encyclopedia of Type Strains, Phase I: KMG project. Here we report the main features of the draft genome of the strain...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29093126/case-6-fever-myalgia-weakness-and-dark-urine-in-a-15-year-old-boy
#19
Joy Miller, Caitlin Nichols, Sarah Varghese
No abstract text is available yet for this article.
November 2017: Pediatrics in Review
https://www.readbyqxmd.com/read/29092975/susuk-or-charm-needle-a-strange-object-detected-on-orthodontic-diagnostic-radiographs
#20
Eby Varghese, Renu Sarah Samson, Sumanth Kumbargere Nagraj, Pramod Redder Chandrappa
No abstract text is available yet for this article.
November 1, 2017: BMJ Case Reports
keyword
keyword
13069
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"