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https://www.readbyqxmd.com/read/28736936/invasive-fungal-infection-following-chemotherapy-for-acute-myeloid-leukaemia-experience-from-a-developing-country
#1
Anu Korula, Aby Abraham, Fouzia N Abubacker, Auro Viswabandya, Kavitha M Lakshmi, O C Abraham, Priscilla Rupali, George M Varghese, Joy S Michael, Alok Srivastava, Vikram Mathews, Biju George
The incidence of invasive fungal infections (IFI) is believed to be higher in patients with acute myeloid leukaemia (AML) undergoing chemotherapy in non-HEPA-filtered rooms. The aim of this study is to review the incidence of IFI in a large cohort of patients with AML treated at a single centre in India. Two hundred and twenty-two patients with AML treated with either induction chemotherapy or salvage chemotherapy between 2008 and 2013 were studied retrospectively. IFI was defined as per the revised EORTC-MSG criteria...
July 23, 2017: Mycoses
https://www.readbyqxmd.com/read/28734455/translocation-of-intramural-coronary-artery-during-switch-procedure-a%C3%A2-new%C3%A2-technique
#2
Roy Varghese, Jai Ganesh, Ravi Agarwal, Sivakumar Kothandam
Intramural course of a coronary artery is a rare association in patients with transposition of great arteries. Various techniques have been described for translocation of these during the arterial switch procedure, with mixed results. This report focuses on a novel technique that is reproducible and provides an alternative in this difficult subset of patients.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28729323/gait-outcomes-of-older-adults-receiving-subacute-hospital-rehabilitation-following-orthopaedic-trauma-a-longitudinal-cohort-study
#3
Saira A Mathew, Paul Varghese, Suzanne S Kuys, Kristiann C Heesch, Steven M McPhail
OBJECTIVES: This study aimed to describe gait speed at admission and discharge from inpatient hospital rehabilitation among older adults recovering from orthopaedic trauma and factors associated with gait speed performance and discharge destination. DESIGN: A longitudinal cohort study was conducted. SETTING: Australian tertiary hospital subacute rehabilitation wards. PARTICIPANTS: Patients aged ≥60 years recovering from orthopaedic trauma (n=746, 71% female) were eligible for inclusion...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28728339/don-t-be-depth-charged-by-the-depth-gauge
#4
Bilal Rafique, Jajini Varghese, Neil Toft
No abstract text is available yet for this article.
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28719088/understanding-and-managing-the-risk-of-head-impact-from-in-hospital-falls-a-cross-sectional-analysis-of-data-from-166-public-hospitals
#5
Satyan R Chari, Paul Varghese, Rebecca A R Bell, Kate Smith, Terry P Haines
BACKGROUND: Falls are a leading cause of preventable harm in the hospitalized elderly, and head impacts (HIs) can be a precursor to serious injury. The aim of this study was to examine if the risk of fall-related HI can be explained by incident characteristics. METHODS: All reported falls across public hospital facilities in the state of Queensland, Australia, over a 2-year period were analyzed using univariate and multiple logistic regression. RESULTS: In all, 650 instances of HI were reported across 24 218 falls...
July 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28718259/counterforce-orthosis-in-the-management-of-lateral-epicondylitis
#6
Daison Varghese Vellilappilly, Heroor Ravindranath Rai, Jaison Varghese, Vishnu Renjith
BACKGROUND: Lateral Epicondylitis (LE), is a condition characterized by the pain and tenderness over the lateral epicondyle of the humerus. LE is commonly seen among people who are involved in sports such as tennis and golf. Any activity that repeatedly overstrains the extensor carpi radialis brevis tendon can lead to LE. The management of lateral epicondylitis generally involves the use of counterforce orthosis. The aim of this review is to summarize the evidence regarding the effectiveness of counterforce orthoses on the clinical outcomes of patients with lateral epicondylitis...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28716030/modeling-de-novo-granulation-of-anaerobic-sludge
#7
Anna Doloman, Honey Varghese, Charles D Miller, Nicholas S Flann
BACKGROUND: A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to the need to consider not just single-cell metabolic processes, but also the multicellular organization and development of the granule. RESULTS: In this computational experiment, we address the role that physiochemical and biological processes play in granulation and provide a literature-validated working model of anaerobic granule de novo formation...
July 17, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28715718/when-speaker-identity-is-unavoidable-neural-processing-of-speaker-identity-cues-in-natural-speech
#8
Alba Tuninetti, Kateřina Chládková, Varghese Peter, Niels O Schiller, Paola Escudero
Speech sound acoustic properties vary largely across speakers and accents. When perceiving speech, adult listeners normally disregard non-linguistic variation caused by speaker or accent differences, in order to comprehend the linguistic message, e.g. to correctly identify a speech sound or a word. Here we tested whether the process of normalizing speaker and accent differences, facilitating the recognition of linguistic information, is found at the level of neural processing, and whether it is modulated by the listeners' native language...
July 14, 2017: Brain and Language
https://www.readbyqxmd.com/read/28708959/assessment-of-the-potential-public-health-impact-of-herpes-zoster-vaccination-in-germany
#9
Desmond Curran, Desirée Van Oorschot, Lijoy Varghese, Lidia Oostvogels, Tomas Mrkvan, Romulo Colindres, Alfred von Krempelhuber, Anastassia Anastassopoulou
The aim of this study was to compare the public health impact of introducing two Herpes Zoster (HZ) vaccines, Zoster Vaccine Live (ZVL) versus a non-live adjuvanted subunit candidate vaccine (HZ/su), in the German population aged 50+ years split into three age cohorts, i.e. 50-59, 60-69 and 70+ years, respectively. A multi-cohort static Markov model was developed following age cohorts over their lifetime. Demographic data were obtained from the German federal statistical office. HZ incidence and the proportion of HZ individuals developing post-herpetic neuralgia (PHN) were derived from German specific sources...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28706780/neurosensory-evaluation-of-inferior-alveolar-nerve-after-bilateral-sagittal-split-ramus-osteotomy-of-mandible
#10
P G Antony, Aneesh Sebastian, K George Varghese, C R Sobhana, S Mohan, C S Soumithran, Shiney Domnic, N Jayakumar
Mandibular skeletal deformities are mostly corrected by Sagittal Split Ramus Osteotomy. One of the main complications of Bilateral Sagittal Split Ramus Osteotomy is impairement of sensory function of Inferior Alveolar Nerve. OBJECTIVES: To evaluate the occurrence of neurosensory disturbance by comparing the subjective and objective assessment of neurosensory responses after bilateral sagittal split ramus osteotomy.To assess the progress of recovery from the first post operative day till six months...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28694797/genome-data-provides-high-support-for-generic-boundaries-in-burkholderia-sensu-lato
#11
Chrizelle W Beukes, Marike Palmer, Puseletso Manyaka, Wai Y Chan, Juanita R Avontuur, Elritha van Zyl, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, T B K Reddy, Chris Daum, Nicole Shapiro, Victor Markowitz, Natalia Ivanova, Nikos Kyrpides, Tanja Woyke, Jochen Blom, William B Whitman, Stephanus N Venter, Emma T Steenkamp
Although the taxonomy of Burkholderia has been extensively scrutinized, significant uncertainty remains regarding the generic boundaries and composition of this large and heterogeneous taxon. Here we used the amino acid and nucleotide sequences of 106 conserved proteins from 92 species to infer robust maximum likelihood phylogenies with which to investigate the generic structure of Burkholderia sensu lato. These data unambiguously supported five distinct lineages, of which four correspond to Burkholderia sensu stricto and the newly introduced genera Paraburkholderia, Caballeronia, and Robbsia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28689530/congenital-vallecular-cyst-arare-and-potentially-lethal-condition
#12
Shabbir Ahmed Mallick, Tabinda Naz Qureshi, Ajoy Methew Varghese, Mona Mohammed Al Busaidi
Congenital vallecular cyst is a rare laryngeal lesion, accounting for 10-20% of all laryngeal cysts, with a potential to cause severe upper airway obstruction, which can be fatal. It can cause stridor, apnea, cyanosis, respiratory distress, and feeding difficulties. Diagnosis requires a high level of clinical suspicion and helps in timely intervention. Direct laryngoscopy is gold standard for definitive diagnosis. Treatment options include aspiration, marsupialization, and surgical excision. Here, we report a case of 7-week-old infant with complain of recurrent episodes of cyanosis when agitated, since the age of 3 weeks, admitted with impression of apparent life-threatening events (ALTEs)...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28689110/persistent-organic-pollutants-in-infants-and-toddlers-relationship-between-concentrations-in-matched-plasma-and-faecal-samples
#13
Yiqin Chen, Andreas Sjodin, Michael S McLachlan, Karin English, Lesa L Aylward, Leisa-Maree L Toms, Julie Varghese, Peter D Sly, Jochen F Mueller
Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13±4.8months), including a repeat sample time point for 13 infants (~5months apart). We observed higher rates of POP quantification in faeces (2g dry weight) than in plasma (0...
July 6, 2017: Environment International
https://www.readbyqxmd.com/read/28688645/financial-benefit-of-a-smoking-cessation-program-prior-to-elective-colorectal-surgery
#14
Cameron E Gaskill, Catherine E Kling, Thomas K Varghese, David L Veenstra, Richard C Thirlby, David R Flum, Rafael Alfonso-Cristancho
BACKGROUND: Cigarette smoking increases the risk of postoperative complications nearly 2-fold. Preoperative smoking cessation programs may reduce complications as well as overall postoperative costs. We aim to create an economic evaluation framework to estimate the potential value of preoperative smoking cessation programs for patients undergoing elective colorectal surgery. METHODS: A decision-analytic model from the payer perspective was developed to integrate the costs and incidence of 90-day postoperative complications and readmissions for a cohort of patients undergoing elective colorectal surgery after a smoking cessation program versus usual care...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28683230/observational-scapular-dyskinesis-known-groups-validity-in-patients-with-and-without-shoulder-pain
#15
Hillary A Plummer, Jonathan C Sum, Federico Pozzi, Rini Varghese, Lori A Michener
Study Design Cross-sectional. Background The scapular dyskinesis test (SDT) has demonstrated reliability and validity, but the utility for clinical decision-making is unclear. Objectives Characterize the prevalence of scapular dyskinesis in participants with and without shoulder pain, and to determine the influence of blinding to the presence of shoulder pain on prevalence of scapular dyskinesis. Methods Participants (n=135), 67 with shoulder pain and 68 healthy controls, were included in this study. The SDT was performed by 2 examiners, from a total of 21 physical therapists...
July 6, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28681811/increasing-incidence-of-penicillin-and-cefotaxime-resistant-streptococcus-pneumoniae-causing-meningitis-in-india-time-for-revision-of-treatment-guidelines
#16
Valsan Philip Verghese, Balaji Veeraraghavan, Ranjith Jayaraman, Rosemol Varghese, Ayyanraj Neeravi, Yuvaraj Jayaraman, Kurien Thomas, Sanjay M Mehendale
PURPOSE: Pneumococcal meningitis is a life-threatening infection, requiring prompt diagnosis and effective treatment. Penicillin resistance in pneumococcal infections is a concern. Here, we present the antibiotic susceptibility profile of pneumococcal meningeal isolates from January 2008 to August 2016 to elucidate treatment guidelines for pneumococcal meningitis. MATERIALS AND METHODS: Invasive pneumococcal isolates from all age groups, were included in this study...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28672270/the-utility-of-biochemical-physiological-and-morphological-biomarkers-of-leaf-sulfate-levels-in-establishing-brachylaena-discolor-leaves-as-a-bioindicator-of-so2-pollution
#17
Candyce Ann Areington, Boby Varghese, Sershen
The negative impacts of air pollution have made monitoring of air quality increasingly important, especially in heavily industrialized areas such as the South Durban Basin (SDB), in South Africa. Bioindicators such as trees can complement conventional air quality monitoring and be used to prioritise vulnerable areas. This study assessed the utility of Brachylaena discolor DC. tree leaves as a bioindicator of sulfur dioxide pollution. This involved correlating ground level sulfur dioxide concentrations ([SO2]) with B...
June 23, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28663608/comparison-of-usefulness-of-ketamine-and-magnesium-sulfate-nebulizations-for-attenuating-postoperative-sore-throat-hoarseness-of-voice-and-cough
#18
Sunil Rajan, George Jacob Malayil, Rekha Varghese, Lakshmi Kumar
CONTEXT: Postoperative sore throat (POST) is a complication that is unresolved in patients undergoing endotracheal intubation. AIM: To compare the effects of ketamine and magnesium sulfate nebulizations in two strengths, on the incidence and severity of POST, hoarseness, and cough. SETTINGS AND DESIGN: Sixty surgical patients undergoing elective abdominal and lower limb surgeries under combined epidural and general anesthesia were included in this prospective, randomized, double-blinded study...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28658918/efficacy-of-neem-extract-and-three-antimicrobial-agents-incorporated-into-tissue-conditioner-in-inhibiting-the-growth-of-c-albicans-and-s-mutans
#19
Dikshita Ray Barua, Jayaprakash Mugur Basavanna, Rana Kalappattil Varghese
INTRODUCTION: Denture stomatitis is an inflammatory condition which compromises the mucosal surface beneath dentures. The aetiology of denture stomatitis is usually multifactorial which varies from trauma from ill fitting denture to poor immune system. There are evidences that denture stomatitis is an outcome of multispecies biofilms that include Candida albicans and Streptococcus mutans. Tissue conditioners are found to be more susceptible to colonisation by micro-organisms. AIM: The purpose of this study was to compare the efficacy of neem leaf extract and three other antimicrobial agents incorporated in a tissue conditioner against both Candida albicans and Streptococcus mutans...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658916/evaluation-of-surface-microhardness-following-chemical-and-microwave-disinfection-of-commercially-available-acrylic-resin-denture-teeth
#20
Nitasha Gandhi, Smitha Daniel, Sushant Benjamin, Nirmal Kurian, Vinaya Susan Varghese
INTRODUCTION: Denture disinfection is an indispensable procedure for preventing cross contamination and the maintenance of a healthy oral mucosa in patients rehabilitated with removable dental prosthesis. Nevertheless, they are known to cause changes in the physical and mechanical properties of denture base resins and acrylic resin denture teeth following immersion of a denture in a suitable chemical disinfectant solution or by undergoing microwave irradiation. One such mechanical property indicator for artificial tooth materials is hardness...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
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