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https://www.readbyqxmd.com/read/28642965/erratum-to-development-of-a-unifying-target-and-consensus-indicators-for-global-surgical-systems-strengthening-proposed-by-the-global-alliance-for-surgery-obstetric-trauma-and-anaesthesia-care-the-g4-alliance
#1
Adil Haider, John W Scott, Colin D Gause, Mira Meheš, Grace Hsiung, Albulena Prelvukaj, Dana Yanocha, Lauren M Baumann, Faheem Ahmed, Na'eem Ahmed, Sara Anderson, Herve Angate, Lisa Arfaa, Horacio Asbun, Tigistu Ashengo, Kisembo Asuman, Ruben Ayala, Stephen Bickler, Saul Billingsley, Peter Bird, Matthijs Botman, Marilyn Butler, Jo Buyske, Angelo Capozzi, Kathleen Casey, Charles Clayton, James Cobey, Michael Cotton, Dan Deckelbaum, Miliard Derbew, Catherine deVries, Jeanne Dillner, Max Downham, Natalie Draisin, David Echinard, Sohier Elneil, Ahmed ElSayed, Abigail Estelle, Allen Finley, Erica Frenkel, Philip K Frykman, Florin Gheorghe, Julian Gore-Booth, Richard Henker, Jaymie Henry, Orion Henry, Laura Hoemeke, David Hoffman, Iko Ibanga, Eric V Jackson, Pankaj Jani, Walter Johnson, Andrew Jones, Zeina Kassem, Asuman Kisembo, Abbey Kocan, Sanjay Krishnaswami, Robert Lane, Asad Latif, Barbara Levy, Dimitrios Linos, Peter Linz, Louis A Listwa, Declan Magee, Emmanuel Makasa, Michael L Marin, Claude Martin, Kelly McQueen, Jamie Morgan, Richard Moser, Robert Neighbor, William M Novick, Stephen Ogendo, Akinyinka Omigbodun, Bisola Onajin-Obembe, Neil Parsan, Beverly K Philip, Raymond Price, Shahnawaz Rasheed, Marjorie Ratel, Cheri Reynolds, Steven M Roser, Jackie Rowles, Lubna Samad, John Sampson, Harshadkumar Sanghvi, Marchelle L Sellers, David Sigalet, Bruce C Steffes, Erin Stieber, Mamta Swaroop, John Tarpley, Asha Varghese, Julie Varughese, Richard Wagner, Benjamin Warf, Neil Wetzig, Susan Williamson, Joshua Wood, Anne Zeidan, Lewis Zirkle, Brendan Allen, Fizan Abdullah
No abstract text is available yet for this article.
June 22, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28639213/study-on-photophysical-properties-of-n-arylphthalamic-acid-derivative-containing-1-2-4-triazole-scaffold
#2
K B Akshaya, Anitha Varghese, Y N Sudhakar, Prajwal Lourdes Lobo, Louis George
A novel N-arylphthalamic acid derivative, 2-({4-[(1H-1,2,4-triazol-1-yl)methyl]phenyl}carbamoyl)benzoic acid (TMPCB) was synthesized and their absorption and emission spectra were recorded in fifteen different solvents of varying polarities at room temperature. Ground state dipole moment of the derivative was calculated experimentally by Guggenheim method and solvatochromic approach proposed by Bilot-Kawski. The singlet excited state dipole moment of TMPCB were calculated experimentally based on different approaches of solvent polarity function proposed by Lippert-Mataga, Bakhshiev, Kawskii-Chamma-Viallet, Reichardt and Bilot-Kawski...
June 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28628003/clinical-effectiveness-and-cost-effectiveness-results-from-the-randomised-phase-iib-trial-in-previously-untreated-patients-with-chronic-lymphocytic-leukaemia-to-compare-fludarabine-cyclophosphamide-and-rituximab-with-fludarabine-cyclophosphamide-mitoxantrone
#3
Dena R Howard, Talha Munir, Lucy McParland, Andy C Rawstron, Anna Chalmers, Walter M Gregory, John L O'Dwyer, Alison Smith, Roberta Longo, Abraham Varghese, Alexandra Smith, Peter Hillmen
BACKGROUND: The conventional frontline therapy for fit patients with chronic lymphocytic leukaemia (CLL) is fludarabine, cyclophosphamide and rituximab (FCR). Rituximab (Mabthera(®), Roche Products Ltd) targets the CD20 antigen, which is expressed at low levels in CLL. The standard dose of rituximab in CLL (375 mg/m(2) in cycle 1 and 500 mg/m(2) in cycles 2-6) was selected based on toxicity data only. Small doses of rituximab (as low as 20 mg) have biological activity in CLL, with an immediate reduction in circulating CLL cells and down-regulation of CD20...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28621377/controlling-the-oxidation-of-bis-tridentate-cobalt-ii-complexes-having-bis-2-pyridylalkyl-amines-ligand-vs-metal-oxidation
#4
S Anjana, S Donring, P Sanjib, B Varghese, Narasimha N Murthy
Two bis-tridentate chelated cobalt(ii) complexes, which differ in the ligand structure by a methylene group, activate molecular oxygen (O2), and give different oxidation products. The O2 reaction of [Co(II)(pepma)2](2+) (1) with unsymmetrical 2-(2-pyridyl)-N-(2-pyridylmethyl)ethanamine (pepma) results in ligand oxidation, to the corresponding Co(ii) imine complex [Co(II)(pepmi)2](2+) (2). Contrastingly, the Co(ii) complex [Co(II)(bpma)2](2+) (3) of similar symmetrical bis(2-pyridylmethyl)amine (bpma), undergoes metal oxidation, yielding a cobalt(iii) complex, [Co(III)(bpma)2](2+) (4)...
June 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28619793/draft-genome-sequence-of-methylocapsa-palsarum-ne2-t-an-obligate-methanotroph-from-subarctic-soil
#5
Kirill K Miroshnikov, Alena Didriksen, Daniil G Naumoff, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Supratim Mukherjee, T B K Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Nikos Kyrpides, Tanja Woyke, Svetlana N Dedysh, Mette M Svenning
Methylocapsa palsarum NE2(T) is an aerobic, mildly acidophilic, obligate methanotroph. Similar to other Methylocapsa species, it possesses only a particulate methane monooxygenase and is capable of atmospheric nitrogen fixation. The genome sequence of this typical inhabitant of subarctic wetlands and soils also contains genes indicative of aerobic anoxygenic photosynthesis.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619486/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-2-visual-performance-after-1-week-of-lens-wear
#6
Ravi C Bakaraju, Daniel Tilia, Jennifer Sha, Jennie Diec, Jiyoon Chung, Danny Kho, Shona Delaney, Anna Munro, Varghese Thomas
PURPOSE: To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals, after 1 week of lens wear. METHODS: In a prospective, participant-masked, cross-over, randomized, 1-week dispensing clinical-trial, 43 presbyopes [age: 42-63 years] each wore AIROPTIX Aqua multifocal (AOMF), ACUVUE OASYS for presbyopia (AOP) and extended-depth-of-focus prototypes (EDOF) appropriate to their add requirements...
June 12, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28615898/teratogenic-effects-of-carbamazepine-in-mice
#7
Manna Jose, Harikrishnan Vijayakumar Sreelatha, Manjula Valiyamattathil James, Sabareeswaran Arumughan, Sanjeev Varghese Thomas
OBJECTIVES: The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. MATERIALS AND METHODS: Mature female and male BALB/c mice (25-30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated groups (CBZ 450 mg/kg and 600 mg/kg) were fed on medicinal diet. The dams in the control group were mated on the same day as that of the CBZ-treated dams. After cesarean section (CS), fetal viability status and weights were recorded...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28615760/use-of-mobile-phone-technology-to-improve-follow-up-at-a-community-mental-health-clinic-a-randomized-control-trial
#8
Gaurav Singh, Narayana Manjunatha, Sabina Rao, H N Shashidhara, Sydney Moirangthem, Rajendra K Madegowda, B Binukumar, Mathew Varghese
BACKGROUND: Mobile phone technology is being used worldwide to improve follow-ups in health care. AIM: Aim of the study is to evaluate whether the use of mobile technology will improve or not the follow-up of Indian patients from a community mental health center. MATERIALS AND METHODS: Patients or caregivers having mobile phones and consenting for study were enrolled, and sociodemographic and clinical details of patients were taken. Participants were randomized into two groups (short message service [SMS] vs...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28604660/1-003-reference-genomes-of-bacterial-and-archaeal-isolates-expand-coverage-of-the-tree-of-life
#9
Supratim Mukherjee, Rekha Seshadri, Neha J Varghese, Emiley A Eloe-Fadrosh, Jan P Meier-Kolthoff, Markus Göker, R Cameron Coates, Michalis Hadjithomas, Georgios A Pavlopoulos, David Paez-Espino, Yasuo Yoshikuni, Axel Visel, William B Whitman, George M Garrity, Jonathan A Eisen, Philip Hugenholtz, Amrita Pati, Natalia N Ivanova, Tanja Woyke, Hans-Peter Klenk, Nikos C Kyrpides
We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space. These genomes double the number of existing type strains and expand their overall phylogenetic diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their phylogenetic and functional interpretation...
June 12, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28598067/is-this-the-right-direction-for-dengue-fever-research-in-india
#10
Sunitha M Daniel, Abraham M Varghese
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28597767/increased-mortality-from-complications-of-pulmonary-hypertension-in-patients-undergoing-transcatheter-aortic-valve-replacement
#11
Raj Parikh, Benson Varghese, Huma N Khatoon, Julie A Kovach, Clifford J Kavinsky, Rajive Tandon
Aortic stenosis (AS) leads to pulmonary hypertension (PH) and right ventricle (RV) failure. Our goal was to describe mortality related to postoperative complications in PH patients undergoing transcatheter aortic valve replacement (TAVR). Ninety-three TAVR patients were analyzed (controls, sPAP < 50 mmHg; cases, sPAP ≥ 50 mmHg). Significant findings in cases included increased mortality (365 days), post-TAVR atrioventricular block (AVB) and acute kidney injury (AKI), and increased mean length of stay (LOS)...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28596055/posterior-aortic-root-enlargement-during-aortic-valve-replacement-role-of-intraoperative-transesophageal-echocardiography
#12
Neelam Aggarwal, Shrinivas V Gadhinglajkar, Varghese T Panicker, Rupa Sreedhar, Saravana Babu, Deepak Gregory Mathew, Chirag S Prasannakumar
No abstract text is available yet for this article.
February 22, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28595851/delineation-of-post-procedure-ablation-regions-with-electrode-displacement-elastography-with-a-comparison-to-acoustic-radiation-force-impulse-imaging
#13
Wenjun Yang, Tomy Varghese, Timothy Ziemlewicz, Marci Alexander, Meghan Lubner, James Louis Hinshaw, Shane Wells, Fred T Lee
We compared a quasi-static ultrasound elastography technique, referred to as electrode displacement elastography (EDE), with acoustic radiation force impulse imaging (ARFI) for monitoring microwave ablation (MWA) procedures on patients diagnosed with liver neoplasms. Forty-nine patients recruited to this study underwent EDE and ARFI with a Siemens Acuson S2000 system after an MWA procedure. On the basis of visualization results from two observers, the ablated region in ARFI images was recognizable on 20 patients on average in conjunction with B-mode imaging, whereas delineable ablation boundaries could be generated on 4 patients on average...
June 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28594459/computer-vision-syndrome-a-common-cause-of-unexplained-visual-symptoms-in-the-modern-era
#14
REVIEW
Sunil Munshi, Ashley Varghese, Sushma Dhar-Munshi
OBJECTIVES: The aim of this study was to assess the evidence and available literature on the clinical, pathogenetic, prognostic and therapeutic aspects of Computer vision syndrome. METHODS: Information was collected from Medline, Embase & National Library of Medicine over the last 30 years up to March 2016. The bibliographies of relevant articles were searched for additional references. FINDINGS: Patients with Computer vision syndrome present to a variety of different specialists, including General Practitioners, Neurologists, Stroke physicians and Ophthalmologists...
June 8, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28594333/quantification-of-carotid-artery-plaque-stability-with-multiple-region-of-interest-based-ultrasound-strain-indices-and-relationship-with-cognition
#15
Nirvedh Meshram, Tomy Varghese, Carol Mitchell, Daren Jackson, Stephanie Wilbrand, Bruce Hermann, Robert Dempsey
Vulnerability and instability in carotid artery plaque has been assessed based on strain variations using noninvasive ultrasound imaging. We previously demonstrated that carotid plaques with higher strain indices in a region of interest (ROI) correlated to patients with lower cognition, probably due to cerebrovascular emboli arising from these unstable plaques. This work attempts to characterize the strain distribution throughout the entire plaque region instead of being restricted to a single localized ROI...
June 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28593215/cutting-edge-efforts-in-surgical-patient-safety
#16
Thomas K Varghese, Amir A Ghaferi
No abstract text is available yet for this article.
June 7, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28585336/liver-directed-human-amniotic-epithelial-cell-transplantation-improves-systemic-disease-phenotype-in-hurler-syndrome-mouse-model
#17
Natalie S Rodriguez, Lisa Yanuaria, Kevin Murphy R Parducho, Irving M Garcia, Bino A Varghese, Brendan H Grubbs, Toshio Miki
Mucopolysaccharidosis type 1 (MPS1) is an inherited lysosomal storage disorder caused by a deficiency in the glycosaminoglycan (GAG)-degrading enzyme α-l-iduronidase (IDUA). In affected patients, the systemic accumulation of GAGs results in skeletal dysplasia, neurological degeneration, multiple organ dysfunction, and early death. Current therapies, including enzyme replacement and bone marrow transplant, improve life expectancy but the benefits to skeletal and neurological phenotypes are limited. In this study, we tested the therapeutic efficacy of liver-directed transplantation of a placental stem cell, which possesses multilineage differentiation potential, low immunogenicity, and high lysosomal enzyme activity...
June 6, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28584888/autism-spectrum-disorder-neuropathology-and-animal-models
#18
REVIEW
Merina Varghese, Neha Keshav, Sarah Jacot-Descombes, Tahia Warda, Bridget Wicinski, Dara L Dickstein, Hala Harony-Nicolas, Silvia De Rubeis, Elodie Drapeau, Joseph D Buxbaum, Patrick R Hof
Autism spectrum disorder (ASD) has a major impact on the development and social integration of affected individuals and is the most heritable of psychiatric disorders. An increase in the incidence of ASD cases has prompted a surge in research efforts on the underlying neuropathologic processes. We present an overview of current findings in neuropathology studies of ASD using two investigational approaches, postmortem human brains and ASD animal models, and discuss the overlap, limitations, and significance of each...
June 5, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28579573/dinuclear-cobalt-ii-complexes-with-double-phosphate-ester-bridges-and-tetradentate-ligands-having-anisole-or-quinoline-appendages
#19
S S Anjana, Babu Varghese, Edamana Prasad
Phosphate esters provide a rigid and stable polymeric backbone in nucleic acids. Metal complexes with phosphate ester groups have been synthesized as structural and spectroscopic models of phosphate-containing enzymes. Dinucleating ligands are used extensively to synthesize model complexes since they provide the support required to stabilize such complexes. The crystal structures of two dinuclear Co(II) complexes, namely bis(μ-diphenyl phosphato-κ(2)O:O')bis({2-methoxy-N,N-bis[(pyridin-2-yl)methyl]aniline-κ(4)N,N',N'',O}cobalt(II)) bis(perchlorate), [Co(C12H10O4P)2(C19H19N3O)2](ClO4)2, and bis(μ-diphenyl phosphato-κ(2)O:O')bis({N,N-bis[(pyridin-2-yl)methyl]quinolin-8-amine-κ(4)N,N',N'',O}cobalt(II)) bis(perchlorate), [Co(C12H10O4P)2(C21H18N4)2](ClO4)2, with tetradentate 2-methoxy-N,N-bis[(pyridin-2-yl)methyl]aniline (L(1)) and N,N-bis[(pyridin-2-yl)methyl]quinolin-8-amine (L(2)) ligands are reported...
June 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28577955/surgery-versus-chemotherapy-and-radiotherapy-for-early-and-locally-advanced-small-cell-lung-cancer-a-propensity-matched-analysis-of-survival
#20
E Wakeam, S A Acuna, N B Leighl, M E Giuliani, S R G Finlayson, T K Varghese, G E Darling
BACKGROUND: The role of surgery in small cell lung cancer (SCLC) is controversial. Survival outcomes for resection of stage I-IIIA SCLC compared to chemotherapy-based non-surgical treatment (NST) were examined using propensity matching. METHODS: 29,994 clinical stage I-IIIA SCLC patients, including 2,619 undergoing surgery, were identified in the National Cancer Database. Stage-specific propensity scores for receipt of surgery were created. Resected patients were matched 1:1 to those undergoing NST...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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