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https://www.readbyqxmd.com/read/29353248/hypertrophic-osteoarthropathy-in-a-patient-with-known-lung-cancer
#1
Jeremy Neale, James Cameron Spence, Ajay Varghese
No abstract text is available yet for this article.
January 20, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29350831/randomized-trial-on-extended-versus-modified-right-lobe-grafts-in-live-donor-liver-transplantation
#2
Christi Titus Varghese, Viju Kumar Bharathan, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran N Menon, Othiyil Vayoth Sudheer, Puneet Dhar, Sudhindran Surendran
Despite advances in the practice of live donor liver transplantation (LDLT), the optimum surgical approach with respect to the middle hepatic vein (MHV) in right lobe LDLT remains undefined. We designed a randomized trial to compare the early postoperative outcomes in recipients and donors between extended right lobe grafts (ERG: transection plane was maintained to the left of MHV, and division of MHV performed beyond the segment VIII vein) and modified right lobe grafts (MRG: transection plane was maintained to the right of MHV, the segment V and VIII drainage was reconstructed using a conduit of recipient portal vein)...
January 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29347341/spatial-correlations-of-hydrodynamic-fluctuations-in-simple-fluids-under-shear-flow-a-mesoscale-simulation-study
#3
Anoop Varghese, Gerhard Gompper, Roland G Winkler
Hydrodynamic fluctuations in simple fluids under shear flow are demonstrated to be spatially correlated, in contrast to the fluctuations at equilibrium, using mesoscopic hydrodynamic simulations. The simulation results for the equal-time hydrodynamic correlations in a multiparticle collision dynamics (MPC) fluid in shear flow are compared with the explicit expressions obtained from fluctuating hydrodynamics calculations. For large wave vectors k, the nonequilibrium contributions to transverse and longitudinal velocity correlations decay as k^{-4} for wave vectors along the flow direction and as k^{-2} for the off-flow directions...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346887/time-correlation-functions-in-the-lebwohl-lasher-model-of-liquid-crystals
#4
Anoop Varghese, Patrick Ilg
Time correlation functions in the Lebwohl-Lasher model of nematic liquid crystals are studied using theory and molecular dynamics simulations. In particular, the autocorrelation functions of angular momentum and nematic director fluctuations are calculated in the long-wavelength limit. The constitutive relations for the hydrodynamic currents are derived using a standard procedure based on non-negativity of the entropy production. The continuity equations are then linearized and solved to calculate the correlation functions...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29331577/a-novel-encystation-specific-protein-kinase-regulates-chitin-synthesis-in-entamoeba-invadens
#5
Sintu Kumar Samanta, Sneha Susan Varghese, Deepak Krishnan, Mithu Baidya, Digant Nayak, Sumanta Mukherjee, Sudip K Ghosh
Phosphorylation is an important post-translational modification of proteins and is involved in the regulation of a variety of cellular events. The proteome of Entamoeba invadens, the reptilian counterpart of Entamoeba histolytica consists of an overwhelming number of putative protein kinases, and some may have a role to play in Entamoeba encystation. In this study, we have identified a novel protein kinase named as EiCSpk (Entamoeba invadenscyst specific protein kinase) which expressed almost exclusively during encystation...
January 10, 2018: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29329714/mutation-burden-profile-in-familial-alzheimer-s-disease-cases-from-india
#6
Adhikarla Syama, Somdatta Sen, Lakshmi Narayanan Kota, Biju Viswanath, Meera Purushottam, Mathew Varghese, Sanjeev Jain, Mitradas M Panicker, Odity Mukherjee
This study attempts to identify coding risk variants in genes previously implicated in Alzheimer's disease (AD) pathways, through whole-exome sequencing of subjects (N = 17) with AD, with a positive family history of dementia (familial AD). We attempted to evaluate the mutation burden in genes encoding amyloid precursor protein metabolism and previously linked to risk of dementias. Novel variants were identified in genes involved in amyloid precursor protein metabolism such as PSEN1 (chr 14:73653575, W161C, tgg > tgT), PLAT (chr 8:42039530,G272R), and SORL1 (chr11:121414373,G601D)...
December 12, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29327455/bioactivity-guided-fractionation-of-methanolic-extract-of-terminalia-arjuna-for-its-cyp3a-and-cyp2d-inhibition-in-rat-liver-microsomes
#7
Alice Varghese, Prachi Saboo, Sarika Wairkar
Terminalia arjuna (T. arjuna) is an Indian medicinal plant belonging to the family combretaceae and possesses numerous therapeutic activities including its immense cardio protective activity. In the present work, methanolic bark extract of T. arjuna was evaluated for the CYP3A and CYP2D inhibition potential in rat liver microsomes (RLM). Further, the methanolic bark extract was fractionated successively using increasing polarity solvents starting with petroleum ether, chloroform, ethyl acetate and n-butanol...
January 12, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29326212/complete-genome-sequence-of-thermoanaerobacterium-sp-strain-rbiitd-a-butyrate-and-butanol-producing-thermophile
#8
Ranjita Biswas, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, T B K Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Nikos C Kyrpides, Tanja Woyke, Adam M Guss
Thermoanaerobacterium sp. strain RBIITD was isolated from contaminated rich growth medium at 55°C in an anaerobic chamber. It primarily produces butyrate as a fermentation product from plant biomass-derived sugars. The whole-genome sequence of the strain is 3.4 Mbp, with 3,444 genes and 32.48% GC content.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325988/arboriscoccus-pini-gen-nov-sp-nov-an-endophyte-from-a-pine-tree-of-the-class-alphaproteobacteria-emended-description-of-geminicoccus-roseus-and-proposal-of-geminicoccaceae-fam-nov
#9
Diogo N Proença, William B Whitman, Neha Varghese, Nicole Shapiro, Tanja Woyke, Nikos C Kyrpides, Paula V Morais
Bacterial strain B29T1T was isolated from the endophytic microbial community of a Pinus pinaster tree trunk and characterized. Strain B29T1T stained Gram-negative and formed diplococci that grew optimally at 26-30°C and at pH 6.0-7.0. The G+C content of the DNA was 61.6mol%. The respiratory quinone was ubiquinone 10 (UK-10), and the major fatty acids were C16:0, cyclo-C19:0ω8c and C18:0 12-methyl, representing 64% of the total fatty acids. Phylogenetic analyses based on the 16S rRNA gene sequences placed strain B29T1T within the order Rhodospirillales in a distinct lineage that also included the genus Geminicoccus...
December 22, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29321372/chronic-skin-inflammation-accelerates-macrophage-cholesterol-crystal-formation-and-atherosclerosis
#10
Yvonne Baumer, Qimin Ng, Gregory E Sanda, Amit K Dey, Heather L Teague, Alexander V Sorokin, Pradeep K Dagur, Joanna I Silverman, Charlotte L Harrington, Justin A Rodante, Shawn M Rose, Nevin J Varghese, Agastya D Belur, Aditya Goyal, Joel M Gelfand, Danielle A Springer, Christopher Ke Bleck, Crystal L Thomas, Zu-Xi Yu, Mårten Cg Winge, Howard S Kruth, M Peter Marinkovich, Aditya A Joshi, Martin P Playford, Nehal N Mehta
Inflammation is critical to atherogenesis. Psoriasis is a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides a compelling model to understand potential pathways linking these diseases. A murine model capturing the vascular and metabolic diseases in psoriasis would accelerate our understanding and provide a platform to test emerging therapies. We aimed to characterize a new murine model of skin inflammation (Rac1V12) from a cardiovascular standpoint to identify novel atherosclerotic signaling pathways modulated in chronic skin inflammation...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29316426/clinical-sequencing-defines-the-genomic-landscape-of-metastatic-colorectal-cancer
#11
Rona Yaeger, Walid K Chatila, Marla D Lipsyc, Jaclyn F Hechtman, Andrea Cercek, Francisco Sanchez-Vega, Gowtham Jayakumaran, Sumit Middha, Ahmet Zehir, Mark T A Donoghue, Daoqi You, Agnes Viale, Nancy Kemeny, Neil H Segal, Zsofia K Stadler, Anna M Varghese, Ritika Kundra, Jianjiong Gao, Aijazuddin Syed, David M Hyman, Efsevia Vakiani, Neal Rosen, Barry S Taylor, Marc Ladanyi, Michael F Berger, David B Solit, Jinru Shia, Leonard Saltz, Nikolaus Schultz
Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood. We performed prospective targeted sequencing of 1,134 CRCs. We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, increasing oncogenic WNT pathway alterations to 96% of CRCs. Right-sided primary site in microsatellite stable mCRC was associated with shorter survival, older age at diagnosis, increased mutations, and enrichment of oncogenic alterations in KRAS, BRAF, PIK3CA, AKT1, RNF43, and SMAD4 compared with left-sided primaries...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29306970/preoperative-decolonization-to-reduce-infections-in-urgent-lower-extremity-repairs
#12
Daniel S Urias, Merin Varghese, Thomas Simunich, Shawna Morrissey, Russell Dumire
PURPOSE: Medical implants and surgical site infections (SSIs) can be a burden on both patients and healthcare systems with a significant rise in morbidity, mortality and costs. Preoperatively, our practice of a chlorohexidine gluconate (CHG) washcloth bath or solution shower was supplemented with nasal painting using povidone-iodine skin and nasal antiseptic (PI-SNA). We sought to measure the effectiveness in reducing SSIs in patients undergoing repair of lower extremity fractures. METHODS: A retrospective review of trauma patients undergoing orthopedic operations conducted at Conemaugh Memorial Medical Center from 10/1/2012 through 9/30/2016...
January 6, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29306522/visceral-thromboses-in-pancreas-adenocarcinoma-systematic-review
#13
REVIEW
Angel Mier Hicks, Antonio DeRosa, Michael Raj, Richard Do, Kenneth H Yu, Maeve A Lowery, Anna Varghese, Eileen M O'Reilly
Within gastrointestinal malignancies, primary hepatocellular carcinoma and pancreatic ductal adenocarcinoma (PDAC) are frequently associated with visceral thromboses (VT). Thrombus formation in the portal (PVT), mesenteric (MVT), or splenic vein (SVT) system leads to portal hypertension and intestinal ischemia. VT in PDAC may convey a risk of increased distal thrombosis and poses therapeutic uncertainty regarding the role of anticoagulation. An increasing number of reports describe VT associated with PDAC. It is possible that early diagnosis of these events may help reduce morbidity and speculatively improve oncologic outcomes...
December 12, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29305199/quantitative-contour-analysis-as-an-image-based-discriminator-between-benign-and-malignant-renal-tumors
#14
Felix Y Yap, Darryl H Hwang, Steven Y Cen, Bino A Varghese, Bhushan Desai, Brian D Quinn, Megha Nayyar Gupta, Nieroshan Rajarubendra, Mihir M Desai, Manju Aron, Gangning Liang, Monish Aron, Inderbir S Gill, Vinay A Duddalwar
OBJECTIVES: To investigate whether morphologic analysis can differentiate benign versus malignant renal tumors on clinically acquired imaging. METHODS: Between 2009 and 2014, 3D tumor volumes were manually segmented from contrast-enhanced computerized tomography (CT) images from 150 patients with predominantly solid, non-macroscopic fat-containing renal tumors: 100 renal cell carcinomas (RCC) and 50 benign lesions (e.g. oncocytoma, lipid-poor angiomyolipoma). Tessellated 3D tumor models were created from segmented voxels using MATLAB code...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29285516/semisupervised-learning-using-denoising-autoencoders-for-brain-lesion-detection-and-segmentation
#15
Varghese Alex, Kiran Vaidhya, Subramaniam Thirunavukkarasu, Chandrasekharan Kesavadas, Ganapathy Krishnamurthi
The work explores the use of denoising autoencoders (DAEs) for brain lesion detection, segmentation, and false-positive reduction. Stacked denoising autoencoders (SDAEs) were pretrained using a large number of unlabeled patient volumes and fine-tuned with patches drawn from a limited number of patients ([Formula: see text], 40, 65). The results show negligible loss in performance even when SDAE was fine-tuned using 20 labeled patients. Low grade glioma (LGG) segmentation was achieved using a transfer learning approach in which a network pretrained with high grade glioma data was fine-tuned using LGG image patches...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29284938/root-canal-configuration-of-human-permanent-mandibular-first-molars-of-an-indo-dravidian-population-based-in-southern-india-an-in-vitro-study
#16
J V Karunakaran, Leo Sujith Samuel, Yousef Rishal, M Derick Joseph, K Rahul Suresh, Sam T Varghese
Aim: This study aims to analyze root canal configuration of human permanent mandibular first molars of an indo-Dravidian population based in southern India. Materials and Methods: A total of 1147 mandibular first permanent molars were collected, cleansed, and stored. The number of roots was recorded, access preparations made, pattern of orifices recorded after pulpal floor debridement, dye injected into the canals using apical negative pressure and subjected to a clearing technique...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284936/maternal-risk-factors-and-periodontal-disease-a-cross-sectional-study-among-postpartum-mothers-in-tamil-nadu
#17
Rohini Govindasamy, Manikandan Dhanasekaran, Sheeja S Varghese, V R Balaji, B Karthikeyan, Ananthi Christopher
Background and Aim: It is inconclusive that periodontitis is an independent risk factor for adverse pregnancy outcomes. This study aims to investigate the association between maternal periodontitis and preterm and/or low birth weight babies. Settings and Design: This was a prospective cross-sectional study. After prior informed consent, 3500 postpartum mothers were selected from various hospitals in Tamil Nadu and categorized into the following groups: group-1 - Normal term normal birth weight (n = 1100); Group-2 - Preterm normal birth weight (n = 400); Group-3 - preterm low birth weight (PTLBW) (n = 1000); and Group-4 - Normal term low birth weight (n = 1000)...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284806/first-2-years-of-experience-of-residential-care-at-sakalawara-rehabilitation-services-national-institute-of-mental-health-and-neurosciences-bengaluru-india
#18
Narayana Manjunatha, Preeti Pansari Agarwal, Harihara N Shashidhara, Mohan Palakode, E Aravind Raj, Aruna Rose Mary Kapanee, Prashanthi Nattala, C Naveen Kumar, Paulomi Sudhir, Jagadisha Thirthalli, Srikala Bharath, Kasi Sekar, Mathew Varghese
Introduction: There is an unmet need for continuity-of-care is well known for those with severe mental disorders (SMDs) after acute care at hospitals in India. The "Sakalawara Rehabilitation Services (SRS)" functioned from March 2014 at "Sakalawara Community Mental Health Centre" (SCMHC) of "National Institute of Mental Health and Neurosciences," Bengaluru, India in the concepts of residential care (half-way-home) with the aim to develop a replicable model. Aim: To review the inpatient records after the initial 2 years of experience in residential care at SCMHC...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29276372/zdhhc3-as-a-risk-and-mortality-marker-for-breast-cancer-in-african-american-women
#19
Nick Kinney, Robin T Varghese, Ramu Anandakrishnan, Harold R Skip Garner
African American woman are 43% more likely to die from breast cancer than white women and have increased the risk of tumor recurrence despite lower incidence. We investigate variations in microsatellite genomic regions-a type of repetitive DNA-and possible links to the breast cancer mortality gap. We screen 33 854 microsatellites in germline DNA of African American women with and without breast cancer: 4 are statistically significant. These are located in the 3' UTR (untranslated region) of gene ZDHHC3, an intron of transcribed pseudogene INTS4L1, an intron of ribosomal gene RNA5-8S5, and an intergenic region of chromosome 16...
2017: Cancer Informatics
https://www.readbyqxmd.com/read/29275215/uncovering-the-basis-of-viability-loss-in-desiccation-sensitive-trichilia-dregeana-seeds-using-differential-quantitative-protein-expression-profiling-by-itraq
#20
Anushka Moothoo-Padayachie, Angus Macdonald, Boby Varghese, Norman W Pammenter, Patrick Govender, Sershen
Recalcitrant seeds, unlike orthodox types, are desiccation sensitive and hence, cannot be stored using conventional seed storage methods In this study, relative changes of protein expression in T. dregeana seeds during desiccation and hydrated storage (a short- to medium-term storage method) were analysed to understand the basis of their desiccation- and storage-induced viability loss. Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) were used to compare (selected) protein expression levels across fresh, partially dehydrated and stored seeds...
December 16, 2017: Journal of Plant Physiology
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