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https://www.readbyqxmd.com/read/29762933/ross-procedure-following-a-dislodged-transcatheter-aortic-valve-replacement
#1
Samuel R Schnittman, Aaron J Weiss, Robin Varghese, Paul Stelzer
A 36-year-old pregnant woman with a history of rheumatic heart disease and prior aortic valve replacement and mitral valve repair presented to an outside hospital with severe aortic stenosis. The patient had a cardiac arrest upon labor induction and underwent a transcatheter aortic valve replacement (TAVR), which dislodged two days later. Five months later, the patient underwent removal of the dislodged TAVR and a Ross procedure at the authors' institution. The patient was stable upon discharge, with minimal aortic and pulmonary regurgitation...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29760999/potential-of-short-wave-infrared-spectroscopy-for-quantitative-depth-profiling-of-stratum-corneum-lipids-and-water-in-dermatology
#2
Anna Ezerskaia, Natallia Eduarda Uzunbajakava, Gerwin J Puppels, Johanna de Sterke, Peter J Caspers, H Paul Urbach, Babu Varghese
We demonstrate the feasibility of short wave infrared (SWIR) spectroscopy combined with tape stripping for depth profiling of lipids and water in the stratum corneum of human skin. The proposed spectroscopic technique relies on differential detection at three wavelengths of 1720, 1750, and 1770 nm, with varying ratio of the lipid-to-water absorption coefficient and an 'isosbestic point'. Comparison of the data acquired using SWIR spectroscopy with that obtained by a gold standard for non-invasive quantitative molecular-specific skin measurements, namely confocal Raman spectroscopy (CRS), revealed specificity of the proposed modality for water and lipid quantification...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760227/socioeconomic-status-and-cardiovascular-outcomes-challenges-and-interventions
#3
REVIEW
William M Schultz, Heval M Kelli, John C Lisko, Tina Varghese, Jia Shen, Pratik Sandesara, Arshed A Quyyumi, Herman A Taylor, Martha Gulati, John G Harold, Jennifer H Mieres, Keith C Ferdinand, George A Mensah, Laurence S Sperling
Socioeconomic status (SES) has a measurable and significant effect on cardiovascular health. Biological, behavioral, and psychosocial risk factors prevalent in disadvantaged individuals accentuate the link between SES and cardiovascular disease (CVD). Four measures have been consistently associated with CVD in high-income countries: income level, educational attainment, employment status, and neighborhood socioeconomic factors. In addition, disparities based on sex have been shown in several studies. Interventions targeting patients with low SES have predominantly focused on modification of traditional CVD risk factors...
May 15, 2018: Circulation
https://www.readbyqxmd.com/read/29759037/deep-head-and-neck-infections-outcome-following-empirical-therapy-with-early-generation-antibiotics
#4
Lalee Varghese, Suma Susan Mathews, John Antony Jude Prakash, V Rupa
In order to study the bacteriological profile, antibiotic sensitivity and outcome following empirical therapy with early generation antibiotics in patients with deep head and neck infection, a retrospective review of 42 patients admitted for drainage and intravenous antibiotic therapy was performed. Ludwig's angina was the commonest infection, with the most common organisms isolated being Group F ß-haemolytic (15%) and non-haemolytic (12.5%) streptococcus. All streptococci and anaerobic gram-positive cocci were susceptible to penicillin...
January 1, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/29758493/spirituality-religiousness-and-coping-in-patients-with-schizophrenia-a-cross-sectional-study-in-a-tertiary-care-hospital
#5
Soumitra Das, Varghese Panickasseril Punnoose, Nimisha Doval, Vijayakrishnan Yathindran Nair
Religion is a form of coping that helps individuals to deal with a wide variety of difficult life situations. But most of the research in this field has been in acute patients of schizophrenia. Also, most of the research on religion and schizophrenia has focused on religion and spirituality as coping mechanisms, and research evaluating the relationship between spirituality/religiousness and repertoire of other coping skills is sparse. Our objective was to evaluate the association between spirituality, religiousness and coping skills in patients with schizophrenia in remission...
April 24, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29758054/effect-of-fusion-protein-cleavage-site-sequence-on-generation-of-a-genotype-vii-newcastle-disease-virus-vaccine
#6
Vinoth K Manoharan, Berin P Varghese, Anandan Paldurai, Siba K Samal
Newcastle disease (ND) causes severe economic loss to poultry industry worldwide. Frequent outbreaks of ND in commercial chickens vaccinated with live vaccines suggest a need to develop improved vaccines that are genetically matched against circulating Newcastle disease virus (NDV) strains. In this study, the fusion protein cleavage site (FPCS) sequence of NDV strain Banjarmasin/010 (Banj), a genotype VII NDV, was individually modified using primer mutagenesis to those of avian paramyxovirus (APMV) serotypes 2, 7 and 8 and compared with the recombinant Banjarmasin (rBanj) with avirulent NDV LaSota cleavage site (rBanj-LaSota)...
2018: PloS One
https://www.readbyqxmd.com/read/29755935/aspergillus-endocarditis-of-the-mitral-valve-with-ventricular-myocardial-invasion-cerebral-vasculitis-and-intracranial-mycotic-aneurysm-formation-in-a-patient-with-hemophagocytic-lymphohistiocytosis
#7
Bibin Varghese, Kevin Ting, Juan Lopez-Mattei, Cezar Iliescu, Joseph Kim, Peter Kim
Aspergillus endocarditis is a rare infection and reported mainly in immunocompromised hosts. We report a case of mitral valve aspergillus endocarditis with ventricular myocardial invasion, cerebral vasculitis and intracranial fungal aneurysm formation in a patient with hemophagocytic lymphohistiocytosis (HLH). This case illustrates the importance of prompt investigation and treatment of masses seen on an echocardiogram for rare infections such as Aspergillus endocarditis in immunocompromised patients.
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29754775/in-situ-gene-therapy-via-aav-crispr-cas9-mediated-targeted-gene-regulation
#8
Ana M Moreno, Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V Shih, John Marlett, Jessica Cabotaje, Jasmine Tat, John Naughton, Leszek Lisowski, Shyni Varghese, Kang Zhang, Prashant Mali
Development of efficacious in vivo delivery platforms for CRISPR-Cas9-based epigenome engineering will be critical to enable the ability to target human diseases without permanent modification of the genome. Toward this, we utilized split-Cas9 systems to develop a modular adeno-associated viral (AAV) vector platform for CRISPR-Cas9 delivery to enable the full spectrum of targeted in situ gene regulation functionalities, demonstrating robust transcriptional repression (up to 80%) and activation (up to 6-fold) of target genes in cell culture and mice...
April 25, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29743798/inasl-position-statements-on-prevention-diagnosis-and-management-of-hepatitis-b-virus-infection-in-india-the-andaman-statements
#9
REVIEW
Anil Arora, Shivaram P Singh, Ashish Kumar, Vivek A Saraswat, Rakesh Aggarwal, Manisha Bangar, Pradip Bhaumik, Harshad Devarbhavi, Radha K Dhiman, Vinod K Dixit, Ashish Goel, Bhabadev Goswami, Dharmesh Kapoor, Kaushal Madan, Jimmy Narayan, Sandeep Nijhawan, Gaurav Pandey, Ramesh R Rai, Manoj K Sahu, Neeraj Saraf, Shalimar, Thrivikrama Shenoy, Varghese Thomas, Manav Wadhawan
Hepatitis B Virus (HBV) infection is one of the major causes of morbidity, mortality and healthcare expenditure in India. There are no Indian consensus guidelines on prevention, diagnosis and management of HBV infection. The Indian National Association for Study of the Liver (INASL) set up a taskforce on HBV in 2016, with a mandate to develop consensus guidelines for diagnosis and management of HBV infection, relevant to disease patterns and clinical practices in India. The taskforce first identified contentious issues on various aspects of HBV management, which were allotted to individual members of the taskforce who reviewed them in detail...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743180/comparison-of-transesophageal-and-transthoracic-echocardiography-under-moderate-sedation-for-guiding-transcatheter-aortic-valve-replacement
#10
Ines Sherifi, Alaa Mabrouk Salem Omar, Mithun Varghese, Menachem Weiner, Ani Anyanwu, Jason C Kovacic, Samin Sharma, Annapoorna Kini, Partho Sengupta
The optimal periprocedural imaging strategy during transcathether aortic valve replacement (TAVR) performed under moderate sedation is debated. Transthoracic echocardiography (TTE) provides suboptimal views due to poorer resolution and patient positioning, whereas use of transesophageal echocardiography (TEE) under moderate sedation is not widely utilized. The aim of our study was to compare the value of TTE in comparison with TEE guidance under moderate sedation during TAVR. The study population included 144 consecutive patients (mean age 83±11 years, 78(54%) females) who had TAVR under moderate sedation using either a TTE (n=96) or TEE (n=48)...
May 9, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29742600/incidental-detection-of-meningioma-by-18f-fmau-pet-ct-in-a-patient-with-suspected-prostate-cancer
#11
Bino Varghese, Erik Velez, Bhushan Desai, Hossein Jadvar
We report on an incidental detection of a meningioma on [F]-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (F-FMAU) PET/CT scan that was performed during a prospective investigation of F-FMAU PET/CT for targeted biopsy of potential sites of tumor in men with suspected prostate cancer based on elevated prostate-specific antigen level. Neither prostate multiparamteric MRI nor F-FMAU PET/CT localized small volume Gleason 3 + 3 tumor deposits. However, an incidental focal high accumulation of F-FMAU was observed in high right parietal lobe that displayed characteristics of a meningioma on a subsequent brain MRI...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29739423/isupport-an-online-training-and-support-program-for-caregivers-of-people-with-dementia-study-protocol-for-a-randomized-controlled-trial-in-india
#12
Kala M Mehta, Dolores Gallagher-Thompson, Mathew Varghese, Santosh Loganathan, Upasana Baruah, Katrin Seeher, Diana Zandi, Tarun Dua, Anne Margriet Pot
BACKGROUND: Dementia has a huge physical, psychological, social and economic impact upon caregivers, families and societies at large. There has been a growing impetus to utilize Internet interventions given the potential scalability, and presumed cost-effectiveness and accessibility. In this paper, we describe the design of a randomized controlled trial (RCT) aiming to study the impact of online self-help programs on caregivers of people with dementia in India. The experimental group will receive an interactive training and support program and the comparison group will receive an education-only e-book...
May 8, 2018: Trials
https://www.readbyqxmd.com/read/29738410/sagittal-spinal-alignment-in-adult-spinal-deformity-an-overview-of-current-concepts-and-a-critical-analysis-review
#13
Sravisht Iyer, Evan Sheha, Michael C Fu, Jeffrey Varghese, Matthew E Cunningham, Todd J Albert, Frank J Schwab, Virginie C Lafage, Han Jo Kim
No abstract text is available yet for this article.
May 1, 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29738287/corrigendum
#14
(no author information available yet)
Varghese JJ, Schmale IL, Mickelsen D, Hansen ME, Newlands SD, Benoit DSW, Korshunov VA, Ovitt CE. 2018. Localized delivery of amifostine enhances salivary gland radioprotection. J Dent Res [epub ahead of print 10 April 2018] in press. (Original DOI: 10.1177/0022034518767408) In the original online article, the third author's name was misspelled as D. Mickelson. This has been corrected to D. Mickelsen online and in print.
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29736066/prevalence-and-correlates-of-sexual-dysfunction-in-male-patients-with-alcohol-dependence-syndrome-a-cross-sectional-study
#15
Deepak Koyilerian Prabhakaran, A Nisha, P Joseph Varghese
Background: Contrary to the popular belief concerning the aphrodisiac effects of alcohol, there exists scientific evidence which conclude on sexual dysfunction caused by chronic alcohol use. There is a dearth of studies from India. Aim: The aim is to estimate the prevalence and correlates of sexual dysfunction in alcohol-dependent patients and to explore the association between sexual dysfunction and various alcohol-related variables. Materials and Methods: The study employed a cross-sectional descriptive design and recruited 84 male patients admitted for de-addiction in a tertiary care center...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29736036/exfoliation-of-a-non-van-der-waals-material-from-iron-ore-hematite
#16
Aravind Puthirath Balan, Sruthi Radhakrishnan, Cristiano F Woellner, Shyam K Sinha, Liangzi Deng, Carlos de Los Reyes, Banki Manmadha Rao, Maggie Paulose, Ram Neupane, Amey Apte, Vidya Kochat, Robert Vajtai, Avetik R Harutyunyan, Ching-Wu Chu, Gelu Costin, Douglas S Galvao, Angel A Martí, Peter A van Aken, Oomman K Varghese, Chandra Sekhar Tiwary, Anantharaman Malie Madom Ramaswamy Iyer, Pulickel M Ajayan
With the advent of graphene, the most studied of all two-dimensional materials, many inorganic analogues have been synthesized and are being exploited for novel applications. Several approaches have been used to obtain large-grain, high-quality materials. Naturally occurring ores, for example, are the best precursors for obtaining highly ordered and large-grain atomic layers by exfoliation. Here, we demonstrate a new two-dimensional material 'hematene' obtained from natural iron ore hematite (α-Fe2 O3 ), which is isolated by means of liquid exfoliation...
May 7, 2018: Nature Nanotechnology
https://www.readbyqxmd.com/read/29728557/flutter-to-tumble-transition-of-buoyant-spheres-triggered-by-rotational-inertia-changes
#17
Varghese Mathai, Xiaojue Zhu, Chao Sun, Detlef Lohse
Heavy particles sink straight in water, while buoyant bubbles and spheres may zigzag or spiral as they rise. The precise conditions that trigger such path-instabilities are still not completely understood. For a buoyant rising sphere, two parameters are believed to govern the development of unsteady dynamics: the particle's density relative to the fluid, and its Galileo number. Consequently, with these parameters specified, the opportunities for variation in particle dynamics appear limited. In contrast to this picture, here we demonstrate that vigorous path-oscillations can be triggered by modulating a spherical particle's moment of inertia (MoI)...
May 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29712566/powiff-prospective-study-of-wrist-internal-fixation-of-fracture-a-protocol-for-a-single-centre-superiority-randomised-controlled-trial-to-study-the-efficacy-of-the-vrp-2-0-distal-radius-plate-austofix-versus-the-va-lcp-depuy-synthes-for-distal-radius-fractures
#18
V D Varghese, Peter Smitham, Stuart Howell, Suzanne Edwards, Mark Rickman
BACKGROUND: Distal radial fractures are one of the most common orthopaedic cases that present to the A&E department. Surgical intervention is warranted in displaced intraarticular fractures and fractures with more than the recommended angulation or shortening, and is most commonly treated with volarly placed fixed angle locking plates. The aim of this study is to determine and compare the efficacy of two different plates for surgical treatment of distal radius fractures. The VRP 2...
April 30, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29705240/cd36-palmitoylation-disrupts-free-fatty-acid-metabolism-and-promotes-tissue-inflammation-in-non-alcoholic-steatohepatitis
#19
Lei Zhao, Chang Zhang, Xiaoxiao Luo, Pei Wang, Wei Zhou, Shan Zhong, Yunxia Xie, Yibo Jiang, Ping Yang, Renkuang Tang, Qin Pan, Andrew R Hall, Tu Vinh Luong, Jiangao Fan, Zac Varghese, John F Moorhead, Massimo Pinzani, Yaxi Chen, Xiong Z Ruan
BACKGROUND AND AIMS: Fatty acid translocase CD36 (CD36) is a membrane protein with multiple immuno-metabolic functions. Palmitoylation has been suggested to regulate the distribution and functions of CD36, but little is known about its significance in NASH. METHODS: Human liver tissue samples were obtained from patients undergoing liver biopsy for diagnostic purposes. CD36 knockout mice were injected with lentivirus vectors to express wild type CD36 and palmitoylation sites mutated CD36 in the livers...
April 26, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29694143/transition-to-the-ultimate-regime-in-two-dimensional-rayleigh-b%C3%A3-nard-convection
#20
Xiaojue Zhu, Varghese Mathai, Richard J A M Stevens, Roberto Verzicco, Detlef Lohse
The possible transition to the so-called ultimate regime, wherein both the bulk and the boundary layers are turbulent, has been an outstanding issue in thermal convection, since the seminal work by Kraichnan [Phys. Fluids 5, 1374 (1962)PFLDAS0031-917110.1063/1.1706533]. Yet, when this transition takes place and how the local flow induces it is not fully understood. Here, by performing two-dimensional simulations of Rayleigh-Bénard turbulence covering six decades in Rayleigh number Ra up to 10^{14} for Prandtl number Pr=1, for the first time in numerical simulations we find the transition to the ultimate regime, namely, at Ra^{*}=10^{13}...
April 6, 2018: Physical Review Letters
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