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https://www.readbyqxmd.com/read/28339605/uniparental-chicken-offsprings-derived-from-oogenesis-of-chicken-primordial-germ-cells-zz-%C3%A2
#1
Chunhai Liu, Il-Kuk Chang, Kamal A Khazanehdari, Shruti Thomas, Preetha Varghese, Vijaya Baskar, Razan Alkhatib, Wenhai Li, Jörg Kinne, Michael J McGrew, Ulrich Wernery
Cloning (somatic cell nuclear transfer) in avian species has proven unachievable due to the physical structure of the avian oocyte. Here, the sexual differentiation of primordial germ cells with genetic sex ZZ (ZZ PGCs) was investigated in female germline chimeric chicken hosts with the aim to produce uniparental offspring. ZZ PGCs were expanded in culture and transplanted into the same and opposite sex chicken embryos which were partially sterilized using irradiation. All tested chimeric roosters (ZZ/ZZ) showed germline transmission with transmission rates of 3...
February 2, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28336937/results-of-the-randomized-phase-iib-arctic-trial-of-low-dose-rituximab-in-previously-untreated-cll
#2
D R Howard, T Munir, L McParland, A C Rawstron, D Milligan, A Schuh, A Hockaday, D J Allsup, S Marshall, A S Duncombe, J L O'Dwyer, A F Smith, R Longo, A Varghese, P Hillmen
ARCTIC was a multi-center, randomized-controlled, open, phase IIB non-inferiority trial in previously untreated Chronic Lymphocytic Leukemia (CLL). Conventional frontline therapy in fit patients is fludarabine, cyclophosphamide and rituximab (FCR). The trial hypothesized that including mitoxantrone with low-dose rituximab (FCM-miniR) would be non-inferior to FCR. 200 patients were recruited to assess the primary endpoint of complete remission (CR) rates according to IWCLL criteria. Secondary endpoints were progression-free survival (PFS), overall survival (OS), overall response rate, minimal residual disease (MRD) negativity, safety and cost-effectiveness...
March 24, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28334134/a-compilation-of-web-based-research-tools-for-mirna-analysis
#3
Vaibhav Shukla, Vinay Koshy Varghese, Shama Prasada Kabekkodu, Sandeep Mallya, Kapaettu Satyamoorthy
Since the discovery of microRNAs (miRNAs), a class of noncoding RNAs that regulate the gene expression posttranscriptionally in sequence-specific manner, there has been a release of number of tools useful for both basic and advanced applications. This is because of the significance of miRNAs in many pathophysiological conditions including cancer. Numerous bioinformatics tools that have been developed for miRNA analysis have their utility for detection, expression, function, target prediction and many other related features...
February 25, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28331271/adenoid-cystic-carcinoma-of-trachea
#4
Ashish Varghese, Swati Suneha, John C Watkinson
Adenoid cystic carcinoma (ACC) is the second most common primary malignant tumor of the trachea, after squamous cell carcinoma. Patients present with upper airway obstructive symptoms and signs including dyspnoea, cough, haemoptysis, and stridor which are often insidious, delaying diagnosis and optimal management. Described here is an unusual case of primary ACC cervical trachea with concomitant micropapillary thyroid carcinoma (microPTC) in a middle-aged lady presenting with cough and breathing difficulty since 3 months...
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28304057/topography-preserved-microwave-plasma-etching-for-top-down-layer-engineering-in-mos2-and-other-van-der-waals-materials
#5
Abin Varghese, Chithra H Sharma, Madhu Thalakulam
A generic and universal layer engineering strategy for van der Waals (vW) materials, scalable and compatible with the current semiconductor technology, is of paramount importance in realizing all-two-dimensional logic circuits and to move beyond the silicon scaling limit. In this letter, we demonstrate a scalable and highly controllable microwave plasma based layer engineering strategy for MoS2 and other vW materials. Using this technique we etch MoS2 flakes layer-by-layer starting from an arbitrary thickness and area down to the mono- or the few-layer limit...
March 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28302769/complete-genome-sequence-of-nitrosomonas-cryotolerans-atcc-49181-a-phylogenetically-distinct-ammonia-oxidizing-bacterium-isolated-from-arctic-waters
#6
Marlen C Rice, Jeanette M Norton, Lisa Y Stein, Jessica Kozlowski, Annette Bollmann, Martin G Klotz, Luis Sayavedra-Soto, Nicole Shapiro, Lynne A Goodwin, Marcel Huntemann, Alicia Clum, Manoj Pillay, Neha Varghese, Natalia Mikhailova, Krishna Palaniappan, Natalia Ivanova, Supratim Mukherjee, T B K Reddy, Chew Yee Ngan, Chris Daum, Nikos Kyrpides, Tanja Woyke
Nitrosomonas cryotolerans ATCC 49181 is a cold-tolerant marine ammonia-oxidizing bacterium isolated from seawater collected in the Gulf of Alaska. The high-quality complete genome contains a 2.87-Mbp chromosome and a 56.6-kbp plasmid. Chemolithoautotrophic modules encoding ammonia oxidation and CO2 fixation were identified.
March 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28300237/modular-synthesis-of-supramolecular-dna-amphiphiles-through-host-guest-interactions-and-their-self-assembly-into-dna-decorated-nanovesicles
#7
Shine K Albert, Hari Veera Prasad Thelu, Murali Golla, Nithiyanandan Krishnan, Reji Varghese
DNA nanostructures have found potential applications in various fields including nanotechnology, materials science and nanomedicine, hence the design and synthesis of DNA nanostructures is extremely important. Self-assembly of DNA amphiphiles provides an efficient strategy for the crafting of soft DNA nanostructures. However, the synthesis of DNA amphiphiles is always challenging. Herein, we show a non-covalent approach based on the host-guest interaction between β-CD and adamantane for the synthesis of DNA amphiphiles, and report their amphiphilicity-driven self-assembly into DNA decorated vesicles...
March 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28298855/day-care-ophthalmic-surgeries-at-a-secondary-care-hospital-in-oman-our-experience
#8
EDITORIAL
Jagdish Bhatia, Bindu Narayanadas, Albert Alfy Hafez Gad, Mathew Varghese, Makari Adel Mansi
No abstract text is available yet for this article.
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28298844/nocardial-pyomyositis
#9
Boby Varkey Maramattom, Rony K Varghese, Anila Sudhakaran, Kurian Ninan
No abstract text is available yet for this article.
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28298048/carotid-atherosclerotic-plaque-instability-and-cognition-determined-by-ultrasound-measured-plaque-strain-in-asymptomatic-patients-with-significant-stenosis
#10
Robert J Dempsey, Tomy Varghese, Daren C Jackson, Xiao Wang, Nirvedh H Meshram, Carol C Mitchell, Bruce P Hermann, Sterling C Johnson, Sara E Berman, Stephanie M Wilbrand
OBJECTIVE This article describes the use of ultrasound measurements of physical strain within carotid atherosclerotic plaques as a measure of instability and the potential for vascular cognitive decline, microemboli, and white matter changes. METHODS Asymptomatic patients with significant (> 60%) carotid artery stenosis were studied for dynamic measures of plaque instability, presence of microemboli, white matter changes, and vascular cognitive decline in comparison with normative controls and premorbid state...
March 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297314/radiation-doses-and-estimated-risk-from-angiographic-projections-during-coronary-angiography-performed-using-novel-flat-detector
#11
Anna Varghese, Roshan S Livingstone, Lijo Varghese, Parveen Kumar, Sirish Chandra Srinath, Oommen K George, Paul V George
Coronary angiography (CA) procedure uses various angiographic projections to elicit detailed information of the coronary arteries with some steep projections involving high radiation dose to patients. This study intends to evaluate radiation doses and estimated risk from angiographic projections during CA procedure performed using novel flat detector (FD) system with improved image processing and noise reduction techniques. Real-time monitoring of radiation doses using kerma-area product (KAP) meter was performed for 140 patients using Philips Clarity FD system...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294557/double-blind-randomized-controlled-trial-of-the-routine-peri-operative-use-of-terlipressin-in-adult-living-donor-liver-transplantation
#12
Mettu Srinivas Reddy, Ilankumaran Kaliamoorthy, Akila Rajakumar, Selvakumar Malleeshwaran, Ellango Appuswamy, Sukanya Lakshmi, Joy Varghese, Mohamed Rela
BACKGROUND: Peri-operative terlipressin (Tp) during living donor liver transplantation (LDLT) has been shown to reduce intra-operative portal pressures and improve renal function. Its role and safety profile has never been evaluated in a double-blinded RCT. AIM: To evaluate the haemodynamic effects, clinical benefits and safety of peri-operative terlipressin infusion in adult LDLT. METHODS: This was a single centre double-blind RCT. Consenting adults with chronic liver disease and low risk of post-transplant renal dysfunction (PTRD) undergoing their first LDLT were randomized...
March 14, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28293964/dosing-strategies-to-optimize-currently-available-anti-mrsa-treatment-options-part-1-iv-options
#13
Ronald G Hall, Michael Thatcher, Wei Wei, Shibin Varghese, Lincy Varughese, Michelle Ndiulor, Kenna D Payne
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a predominant pathogen resulting in significant morbidity and mortality. Optimal dosing of anti-MRSA agents is needed to help prevent the development of antimicrobial resistance and to increase the likelihood of a favorable clinical outcome. Areas covered: This review summarizes the available data for antimicrobials routinely used for MRSA infections that are not administered orally or topically. We make recommendations and highlight the current gaps in the literature...
March 15, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28290426/rapidly-progressive-dementia-with-myoclonus-not-creutzfeldt-jakob-disease
#14
M Saini, N M Varghese, Khin Hnin Su Wai, N K Loh
No abstract text is available yet for this article.
March 2017: Neurology India
https://www.readbyqxmd.com/read/28277386/principal-radiographic-characteristics-for-cervical-spinal-deformity-a-health-related-quality-of-life-analysis
#15
Hongda Bao, Jeffrey Varghese, Renaud Lafage, Barthelemy Liabaud, Bassel Diebo, Subaraman Ramchandran, Louis Day, Cyrus Jalai, Dana Cruz, Thomas Errico, Themistocles Protopsaltis, Peter Passias, Aaron Buckland, Yong Qiu, Frank Schwab, Virginie Lafage
STUDY DESIGN: Retrospective study OBJECTIVE:: To propose radiographic characteristics of patients with cervical disability and to investigate the relevant parameters when assessing cervical alignment. SUMMARY OF BACKGROUND DATA: Although cervical kyphosis is traditionally recognized as presentation of cervical deformity, an increasing number of studies demonstrated that cervical kyphosis may not equal cervical deformity. Therefore, several other differentiating criteria for cervical deformity should be investigated and supported with quality of life scores...
March 8, 2017: Spine
https://www.readbyqxmd.com/read/28277340/update-on-adrenocortical-carcinoma-management-and-future-directions
#16
Jeena Varghese, Mouhammed Amir Habra
PURPOSE OF REVIEW: To present an update on the management of and future directions in adrenocortical carcinoma (ACC). RECENT FINDINGS: ACC is a rare malignancy with high morbidity and mortality. Surgery remains the mainstay treatment for localized disease, but it is often not feasible in more advanced cases. There is an ongoing controversy about the routine use of adjuvant treatments after surgery. Hormonal overproduction can complicate the management and worsen the prognosis of the disease...
March 8, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28275780/design-structural-diversity-and-properties-of-novel-zwitterionic-metal-organic-frameworks
#17
Darpandeep Aulakh, Anthony P Nicoletta, Joshua B Pyser, Juby R Varghese, Mario Wriedt
Seven new zwitterionic metal-organic frameworks (ZW MOFs) of compositions {[Cd(L1)(OH2)]·2H2O}n (1), {[Mn(L1)(OH2)2]·H2O}n (2), {[Cu(HL1)2(OH2)3]·9H2O}n (3), {[Mn2(L2)2(OH2)4]·3H2O}n (4), [Co(L2)(OH2)4]·H2O (5), [Ni(L2)(OH2)3]n (6), and {[Cd(L2)(OH2)3]·4H2O}n (7), where H3L1Br = 3-carboxy-1-(3,5-dicarboxybenzyl)pyridinium bromide and H3L2Br = 4-carboxy-1-(3,5-dicarboxybenzyl)pyridinium bromide, have been synthesized under hydrothermal conditions. We demonstrate that the diversity of these crystal structures suggests that the tridentate and flexible nature of ZW ligands L1 and L2 make them excellent candidates for the synthesis of new ZW MOFs...
March 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28274029/radiotherapy-in-phyllodes-tumour
#18
Sunitha Susan Varghese, Balukrishna Sasidharan, Marie Therese Manipadam, M J Paul, Selvamani Backianathan
INTRODUCTION: Phyllodes Tumour (PT) of the breast is a relatively rare breast neoplasm (<1%) with diverse range of pathology and biological behaviour. AIM: To describe the clinical course of PT and to define the role of Radiotherapy (RT) in PT of the breast. MATERIALS AND METHODS: Retrospective analysis of hospital data of patients with PT presented from 2005 to 2014 was done. Descriptive statistics was used to analyze the results. Simple description of data was done in this study...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28270909/high-quality-permanent-draft-genome-sequence-of-the-bradyrhizobium-elkanii-type-strain-usda-76-t-isolated-from-glycine-max-l-merr
#19
Wayne Reeve, Peter van Berkum, Julie Ardley, Rui Tian, Margaret Gollagher, Dora Marinova, Patrick Elia, T B K Reddy, Manoj Pillay, Neha Varghese, Rekha Seshadri, Natalia Ivanova, Tanja Woyke, Mohamed N Baeshen, Nabih A Baeshen, Nikos Kyrpides
Bradyrhizobium elkanii USDA 76(T) (INSCD = ARAG00000000), the type strain for Bradyrhizobium elkanii, is an aerobic, motile, Gram-negative, non-spore-forming rod that was isolated from an effective nitrogen-fixing root nodule of Glycine max (L. Merr) grown in the USA. Because of its significance as a microsymbiont of this economically important legume, B. elkanii USDA 76(T) was selected as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria sequencing project...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28269041/multi-omic-approaches-for-characterization-of-hepatocellular-carcinoma
#20
Habtom W Ressom, Cristina Di Poto, Alessia Ferrarini, Yunli Hu, Mohammad R Nezami Ranjbar, Ehwang Song, Rency S Varghese, Minkun Wang, Shiyue Zhou, Rui Zhu, Yiming Zuo, Mahlet G Tadesse, Yehia Mechref
Multi-omic approaches offer the opportunity to characterize complex diseases such as cancer at various molecular levels. In this paper, we present transcriptomic, proteomic/glycoproteomic, glycomic, and metabolomic (TPGM) data we acquired by analysis of liver tissues from hepatocellular carcinoma (HCC) cases and patients with liver cirrhosis. We evaluated changes in the levels of transcripts, proteins, glycans, and metabolites between tumor and cirrhotic tissues by statistical methods. We demonstrated the potential of multi-omic approaches and network analysis to investigate the interactions among these biomolecules in the progression of liver cirrhosis to HCC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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