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https://www.readbyqxmd.com/read/29909664/predicting-in-hospital-mortality-in-older-general-surgical-patients
#1
A Vilches-Moraga, J Fox, A Paracha, A Gomez-Quintanilla, J Epstein, L Pearce
Introduction A significant number of emergency general surgical admissions occur in older patients. Clinical decision making in this group is challenging and current risk prediction tools extrapolate data from cohorts of younger patients. This is the first UK study to examine risk factors predicting in-hospital mortality in older acute surgical patients undergoing comprehensive geriatric assessment. Methods This was a prospective study of consecutive patients aged ≥75 years admitted non-electively to general surgery wards between September 2014 and February 2017 who were reviewed by an elderly medicine in-reach service...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#2
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29904747/a-rapid-computational-approach-for-assessing-interfraction-esophageal-motion-for-use-in-stereotactic-body-radiation-therapy-planning
#3
Michael L Cardenas, Thomas R Mazur, Christina I Tsien, Olga L Green
Purpose: We present a rapid computational method for quantifying interfraction motion of the esophagus in patients undergoing stereotactic body radiation therapy on a magnetic resonance (MR) guided radiation therapy system. Methods and materials: Patients who underwent stereotactic body radiation therapy had simulation computed tomography (CT) and on-treatment MR scans performed. The esophagus was contoured on each scan. CT contours were transferred to MR volumes via rigid registration...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29901071/curcumin-inhibits-cell-proliferation-and-motility-via-suppression-of-trop2-in-bladder-cancer-cells
#4
Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue, Yiran Huang
Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family. Trop2 has been described as a cancer driver and is deregulated in various types of cancer...
May 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29896314/mental-stress-as-consequence-and-cause-of-vision-loss-the-dawn-of-psychosomatic-ophthalmology-for-preventive-and-personalized-medicine
#5
REVIEW
Bernhard A Sabel, Jiaqi Wang, Lizbeth Cárdenas-Morales, Muneeb Faiq, Christine Heim
The loss of vision after damage to the retina, optic nerve, or brain has often grave consequences in everyday life such as problems with recognizing faces, reading, or mobility. Because vision loss is considered to be irreversible and often progressive, patients experience continuous mental stress due to worries, anxiety, or fear with secondary consequences such as depression and social isolation. While prolonged mental stress is clearly a consequence of vision loss, it may also aggravate the situation. In fact, continuous stress and elevated cortisol levels negatively impact the eye and brain due to autonomous nervous system (sympathetic) imbalance and vascular dysregulation; hence stress may also be one of the major causes of visual system diseases such as glaucoma and optic neuropathy...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29891182/safety-of-direct-oral-anticoagulants-and-vitamin-k-antagonists-in-oldest-old-patients-a-prospective-study
#6
Carlos Rodríguez-Pascual, Ivett Torres-Torres, Alejandro Gómez-Quintanilla, Ana Isabel Ferrero-Martínez, Jagdish Sharma, Alba Guitián, Maria Carmen Basalo, Marina Montero-Magan, Arturo Vilches-Moraga, Maria-Teresa Olcoz-Chiva, Emilio Paredes-Galán, Fernando Rodríguez-Artalejo
OBJECTIVE: The safety of direct oral anticoagulants (DOACs) in oldest old patients with nonvalvular atrial fibrillation (NVAF) in daily clinical practice has not been systematically assessed. This study examined the safety of DOACs and dicumarol (a vitamin K antagonist) in NVAF geriatric patients. DESIGN: Prospective study from January 2010 through June 2015, with follow-up through January 2016. SETTING: Geriatric medicine department at a tertiary hospital...
June 8, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29890193/opportunities-in-biotechnology
#7
Kevan M A Gartland, Jill S Gartland
Strategies for biotechnology must take account of opportunities for research, innovation and business growth. At a regional level, public-private collaborations provide potential for such growth and the creation of centres of excellence. By considering recent progress in areas such as genomics, healthcare diagnostics, synthetic biology, gene editing and bio-digital technologies, opportunities for smart, strategic and specialised investment are discussed. These opportunities often involve convergent or disruptive technologies, combining for example elements of pharma-science, molecular biology, bioinformatics and novel device development to enhance biotechnology and the life sciences...
June 8, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29886240/s1p-promotes-migration-differentiation-and-immune-regulatory-activity-in-amniotic-fluid-derived-stem-cells
#8
Rita Romani, Giorgia Manni, Chiara Donati, Irene Pirisinu, Caterina Bernacchioni, Marco Gargaro, Matteo Pirro, Mario Calvitti, Giorgia Manni, Francesco Bagaglia, Amirhossein Sahebkar, Graziano Clerici, Davide Matino, Giovanni Pomili, Gian Carlo Di Renzo, Vincenzo Nicola Talesa, Paolo Puccetti, Francesca Fallarino
Stem cells have high potential for cell therapy in regenerative medicine. We previously isolated stem cell types from human amniotic fluid, derived from prenatal amniocentesis. One type, characterized by a fast doubling time, was designated as fast human amniotic stem cells (fHASCs). These cells exhibited high differentiation potential and immunoregulatory properties. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that influences stem-cell pluripotency, differentiation, mobility, and regulates immune functions...
June 7, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29883962/paeonol-attenuates-acute-lung-injury-by-inhibiting-hmgb1-in-lipopolysaccharide-induced-shock-rats
#9
Xia Liu, Qin Xu, Liyan Mei, Hang Lei, Quan Wen, Jifei Miao, Huina Huang, Dongfeng Chen, Shaohui Du, Saixia Zhang, Jianhong Zhou, Rudong Deng, Yiwei Li, Chun Li, Hui Li
High-mobility group box 1 (HMGB1) is a highly conserved DNA-binding nuclear protein that facilitates gene transcription and the DNA repair response. However, HMGB1 may be released by necrotic cells as well as activated monocytes and macrophages following stimulation with lipopolysaccharide (LPS), interleukin-1β (IL-1β), or tumor necrosis factor-α (TNF-α). Extracellular HMGB1 plays a critical role in the pathogenesis of acute lung injury (ALI) through activating the nuclear transcription factor κB (NF-κB) P65 pathway, thus, it may be a promising therapeutic target in shock-induced ALI...
June 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29881663/determination-of-organic-acids-for-quality-evaluation-in-coptis-herbs-by-ion-chromatography
#10
Dongmei Li, Lili Zhou, Qingwei Wang, Yang He
Coptis herbs are important herbal medicinal materials. The bioactive composition, the quality and medicinal efficacy of these herbs, are determined significantly by their geo-authentic features. Among the effective components of these herbs are seven organic acids (quinic, acetic, formic, tartaric, malic, succinic, and oxalic acids). However, no quantitative data of these seven acids in these herbs are available. Therefore, we developed a method for simultaneous separation and determination of the seven organic acids in Coptis herbs using gradient ion chromatography (mobile phase and gradient were shown in Table 1)...
June 2018: 3 Biotech
https://www.readbyqxmd.com/read/29880747/landscape-phage-evolution-from-phage-display-to-nanobiotechnology
#11
REVIEW
Valery A Petrenko
The development of phage engineering technology has led to the construction of a novel type of phage display library-a collection of nanofiber materials with diverse molecular landscapes accommodated on the surface of phage particles. These new nanomaterials, called the "landscape phage", serve as a huge resource of diagnostic/detection probes and versatile construction materials for the preparation of phage-functionalized biosensors and phage-targeted nanomedicines. Landscape-phage-derived probes interact with biological threat agents and generate detectable signals as a part of robust and inexpensive molecular recognition interfaces introduced in mobile detection devices...
June 7, 2018: Viruses
https://www.readbyqxmd.com/read/29870392/the-european-federation-of-clinical-chemistry-and-laboratory-medicine-syllabus-for-postgraduate-education-and-training-for-specialists-in-laboratory-medicine-version-5-2018
#12
Nuthar Jassam, Jennifer Lake, Milena Dabrowska, Jose Queralto, Demetrios Rizos, Ralf Lichtinghagen, Hannsjörg Baum, Ferruccio Ceriotti, John O'Mullane, Evgenija Homšak, Charis Charilaou, Mats Ohlson, Ivana Rako, Dalius Vitkus, Gustav Kovac, Pauline Verschuure, Jaroslav Racek, Mariana Carmen Chifiriuc, Gilbert Wieringa
Although laboratory medicine practise varies across the European Union's (EU) member states, the extent of overlap in scope is such that a common syllabus describing the education and training associated with high-quality, specialist practise can be identified. In turn, such a syllabus can help define the common set of skills, knowledge and competence in a Common Training Framework (CTF) for non-medical Specialists in Laboratory Medicine under EU Directive 2013/55/EU (The recognition of Professional Qualifications)...
June 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29870296/gintonin-modulates-platelet-function-and-inhibits-thrombus-formation-via-impaired-glycoprotein-vi-signaling
#13
Muhammad Irfan, Dahye Jeong, Evelyn Saba, Hyuk-Woo Kwon, Jung-Hae Shin, Bo-Ra Jeon, Suk Kim, Sung-Dae Kim, Dong-Ha Lee, Seung-Yeol Nah, Man Hee Rhee
Panax ginseng (P. ginseng), one of the most valuable medicinal plants, is known for its healing and immunobooster properties and has been widely used in folk medicine against cardiovascular diseases, including stroke and heart attack. In this study, we explored the anti-platelet activity of gintonin (a recently discovered non-saponin fraction of ginseng) against agonist-induced platelet activation. In vitro effects of gintonin on agonist-induced human and rat platelet aggregation, granule secretion, integrin αIIb β3 activation, and intracellular calcium ion ([Ca2+ ]i ) mobilization were examined...
June 5, 2018: Platelets
https://www.readbyqxmd.com/read/29866666/cause-of-irreducible-dislocation-of-a-re-revision-thr
#14
Evelyn Patricia Murphy, Christopher Fenelon, Shane Russell, Finbarr Condon
Instability or recurrent dislocations are a common reason for revision of total hip replacements (THRs). Dual-mobility constructs can help improve stability by increasing the femoral head jump distance. These constructs are used to decrease the risk of re-revision in the setting of recurrent dislocation. This case describes an unusual case of irreducible dislocation of a re-revision THR due to intraprosthetic dislocation. The patient required open reduction and revision of this construct to a tripolar implant...
June 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29857820/behavior-of-multipotent-stem-cells-isolated-in-mobilized-peripheral-blood-from-sheep-after-culture-with-human-chondrogenic-medium
#15
Carlos Landa-Solís, Anell Olivos-Meza, Brenda Olivos-Díaz, Adriana Hernández-Rangel, Víctor Hugo Cárdenas-Soria, Maria Cristina Velasquillo-Martínez, José Clemente Ibarra-Ponce de León
Today, regenerative medicine requires new sources of multipotent stem cells for their differentiation to chondrocytes using the mediums of differentiation available in the market. This study aimed to determine whether the Mesenchymal Stem Cells (MSCs) isolated from Mobilized Peripheral Blood (MPB) in sheep using the Granulocyte Colony-Stimulating Factor (G-CSF), have the ability of first acquire a fibroblast-like morphology after being forced out of the bone marrow niche by G-CSF and second, if the cells have the capacity to express collagen type-II α I in primary culture using a human commercial media of differentiation...
June 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29851684/a-multidisciplinary-approach-to-equipment-use-in-pediatric-patient-mobilization
#16
Katie Parchem, Amanda Peck, Katherine Tales
Research has shown that patients who are mechanically ventilated or immobile for greater than 7 days are at increased risk for deconditioning and muscle atrophy. Immobility impacts length of stay as well as patients' ability to return to their prior level of function. As part of the safe patient-handling initiative created at Michigan Medicine, a special team of nurses and therapists was assembled to adapt an adult mobility framework for the pediatric population. The pediatric mobility model determines each patient's specific mobility "phase" based on detailed criteria...
July 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29851675/reducing-intensive-care-unit-staff-musculoskeletal-injuries-with-implementation-of-a-safe-patient-handling-and-mobility-program
#17
Mary Ann Adamczyk
The purpose of this safety initiative was to reduce work-related injuries through the implementation of a safe patient handling and mobility (SPHM) program in a medical intensive care unit. An SPHM program was implemented on a critical care medicine unit in February of 2017. Nursing and assistive personnel completed education via hands-on and online educational modules regarding SPHM equipment and techniques and an SPHM policy. All staff were expected to follow SPHM practices. Critical care medicine unit nursing leadership and unit-based SPHM peer coaches rounded to ensure staff compliance with the program...
July 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29848468/optimizing-gestational-weight-gain-with-the-eating4two-smartphone-app-protocol-for-a-randomized-controlled-trial
#18
Deborah Davis, Rachel Davey, Lauren T Williams, Maralyn Foureur, Ellen Nohr, Catherine Knight-Agarwal, Tanya Lawlis, Jeremy Oats, Helen Skouteris, Matthew Fuller-Tyszkiewicz
BACKGROUND: Approximately 50% of women gain excessive weight in pregnancy. Optimizing gestational weight gain is important for the short- and long-term health of the childbearing woman and her baby. Despite this, there is no recommendation for routine weighing in pregnancy, and weight is a topic that many maternity care providers avoid. Resource-intensive interventions have mainly targeted overweight and obese women with variable results. Few studies have examined the way that socioeconomic status might influence the effectiveness or acceptability of an intervention to participants...
May 30, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29846309/the-influence-of-daily-stress-on-sedentary-behavior-group-and-person-n-of-1-level-results-of-a-1-year-observational-study
#19
Keith M Diaz, Anusorn Thanataveerat, Faith E Parsons, Sunmoo Yoon, Ying Kuen Cheung, Carmela Alcantara, Andrea T Duran, Ipek Ensari, David J Krupka, Joseph E Schwartz, Matthew M Burg, Karina W Davidson
OBJECTIVES: The purpose of this study, which used mobile technologies to continuously collect data over 1 year, was to examine the association of psychological stress with objectively measured sedentary behavior in adults at both the group (e.g. nomothetic approach) and individual (e.g. idiographic approach) level. METHODS: Data were collected in an observational study of healthy adults (n=79) residing in the New York City metro area who were studied for 365 days from 2014-2015...
May 24, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29845809/-design-of-portable-spirometer-based-on-internet-of-things-of-medicine
#20
Yichen He, Bo Yang, Shiqi Xiong, Qing Li
A kind of portable device for detecting common lung function parameters is mentioned in this paper. Using the singlechip microcomputer as the master control block to collect and process the data from high-accuracy gas pressure sensor, through the way of parametric calibration and linear interpolation to test and calculate the Forced Vital Capacity (FVC), Peak Expiratory Flow (PEF), Forced Expiratory Volume in one second (FEV1), and FEV1/FVC. Meanwhile, the detected parameters can be uploaded to the intelligent mobile terminal through the wireless transmission module...
February 8, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
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