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https://www.readbyqxmd.com/read/29471192/the-effect-of-magnolol-on-ca-2-homeostasis-and-its-related-physiology-in-human-oral-cancer-cells
#1
Shu-Feng Hsieh, Chiang-Ting Chou, Wei-Zhe Liang, Chun-Chi Kuo, Jue-Long Wang, Lyh-Jyh Hao, Chung-Ren Jan
OBJECTIVE: Magnolol, a polyphenol compound from herbal medicines, was shown to alter physiology in various cell models. However, the effect of magnolol on Ca2+ homeostasis and its related physiology in oral cancer cells is unclear. This study examined whether magnolol altered Ca2+ signaling and cell viability in OC2 human oral cancer cells. METHODS: Cytosolic Ca2+ concentrations ([Ca2+ ]i ) in suspended cells were measured by using the fluorescent Ca2+ -sensitive dye fura-2...
February 14, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29468091/surgical-technical-evidence-review-for-elective-total-joint-replacement-conducted-for-the-ahrq-safety-program-for-improving-surgical-care-and-recovery
#2
REVIEW
Christopher P Childers, Anaar E Siletz, Emily S Singer, Claire Faltermeier, Q Lina Hu, Clifford Y Ko, Gregory J Golladay, Stephen L Kates, Elizabeth C Wick, Melinda Maggard-Gibbons
Background: Use of enhanced recovery pathways (ERPs) can improve patient outcomes, yet national implementation of these pathways remains low. The Agency for Healthcare Research and Quality (AHRQ; funder), the American College of Surgeons, and the Johns Hopkins Medicine Armstrong Institute for Patent Safety and Quality have developed the Safety Program for Improving Surgical Care and Recovery-a national effort to catalyze implementation of practices to improve perioperative care and enhance recovery of surgical patients...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29467040/knowledge-sharing-between-general-and-pediatric-emergency-departments-connections-barriers-and-opportunities
#3
Leah K Crockett, Carly Leggett, Janet A Curran, Lisa Knisley, Gwenyth Brockman, Shannon D Scott, Lisa Hartling, Mona Jabbour, Terry P Klassen
CLINICIAN'S CAPSULE What is known about this topic? Evidence-based pediatric emergency care is variably applied across general and pediatric emergency departments. What did this study ask? What are the information-seeking patterns of pediatric emergency medicine network members? What did this study find? There remains a need to share successful methods of local dissemination and implementation across the network, and to leverage local professional champions such as clinical nurse liaisons. Why does this study matter to clinicians? Tailoring knowledge mobilization efforts to end-user priorities is essential to ensure impact and spread of outreach efforts...
February 22, 2018: CJEM
https://www.readbyqxmd.com/read/29463489/mobile-app-delivery-of-the-eortc-qlq-c30-questionnaire-to-assess-health-related-quality-of-life-in-oncological-patients-usability-study
#4
Kerstin A Kessel, Marco Me Vogel, Anna Alles, Sophie Dobiasch, Hanna Fischer, Stephanie E Combs
BACKGROUND: Mobile apps are evolving in the medical field. However, ongoing discussions have questioned whether such apps are really valuable and whether patients will accept their use in day-to-day clinical life. Therefore, we initiated a usability study in our department. OBJECTIVE: We present our results of the first app prototype and patient testing of health-related quality of life (HRQoL) assessment in oncological patients. METHODS: We developed an app prototype for the iOS operating system within eight months in three phases: conception, initial development, and pilot testing...
February 20, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29463292/effectiveness-of-interventions-aimed-at-improving-physical-and-psychological-outcomes-of-fall-related-injuries-in-people-with-dementia-a-narrative-systematic-review
#5
Shannon Robalino, Sarange B Nyakang'o, Fiona R Beyer, Chris Fox, Louise M Allan
BACKGROUND: The annual prevalence of falls in people with dementia ranges from 47 to 90%. Falls are a common reason for hospital admission in people with dementia, and there is limited research evidence regarding the care pathways experienced by this population. In addition to immediate management of an injury, prevention of further falls is likely to be an important part of any successful intervention. This review aims to assess the effectiveness of interventions for improving the physical and psychological wellbeing of people with dementia who have sustained a fall-related injury...
February 20, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29456356/the-current-state-of-rural-neurosurgical-practice-an-international-perspective
#6
REVIEW
Pavan S Upadhyayula, John K Yue, Jason Yang, Harjus S Birk, Joseph D Ciacci
Introduction: Rural and low-resource areas have diminished capacity to care for neurosurgical patients due to lack of infrastructure, healthcare investment, and training programs. This review summarizes the range of rural neurosurgical procedures, novel mechanisms for delivering care, rapid training programs, and outcome differences across international rural neurosurgical practice. Methods: A comprehensive literature search was performed for English language manuscripts with keywords "rural" and "neurosurgery" using the National Library of Medicine PubMed database (01/1971-06/2017)...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29454050/when-travel-is-a-challenge-travel-medicine-and-the-dis-abled-traveller
#7
REVIEW
Irmgard Bauer
Travellers with recognised disabilities or the dis-ability to function as required during a trip have been overlooked in the travel medicine literature. This paper provides a starting point for further discussion and research into this neglected traveller population. In contrast, tourism research has explored travel with a disability for some time in order to understand the travellers' needs and to improve services accordingly. The contemporary bio-psycho-social understanding of disability serves as the framework for exploring motivations to travel as well as barriers, such as inter and intrapersonal, economic, structural and attitudinal obstacles...
February 14, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29447711/no-355-physiologic-basis-of-pain-in-labour-and-delivery-an-evidence-based-approach-to-its-management
#8
Julie Bonapace, Guy-Paul Gagné, Nils Chaillet, Raymonde Gagnon, Emmanuelle Hébert, Sarah Buckley
OBJECTIVE: To review the evidence relating to nonpharmacological approaches in the management of pain during labour and delivery. To formulate recommendations for the usage of nonpharmacological approaches to pain management. OPTIONS: Nonpharmacological methods available for pain management during labour and delivery exist. These should be included in the counselling and care of women. EVIDENCE: PubMed and Medline were searched for articles in French and English on subjects related to "breastfeeding," "pain," "epidural," "anaesthesia," "analgesia," "labour," "labor," and combined with "gate control theory," "alternative therapies," "massage," "position," "mobility," "TENS," "bathing," "DNIC," "acupuncture," "acupressure," "sterile water injection," "higher center," "control mind," "cognitive structuring," "holistic health," "complementary therapy(ies)," "breathing," "relaxation," "mental imagery," "visualization," "mind focusing," "hypnosis," "auto-hypnosis," "sophrology," "mind and body interventions," "music," "odors," "biofeedback," "Lamaze," "Bonapace," "prenatal training," "gymnastic," "chanting," "haptonomy," "environment," "transcutaneous electrical stimulus-stimulation," "antenatal education," "support," "continuous support," "psychosocial support," "psychosomatic medicine," "supportive care," "companion," "intrapartum care," "nurse," "midwife(ves)," "father," "doula," "caregiver," " hormones," "oxytocin," "endorphin," "prolactin," "catecholamine," "adrenaline," and "noradrenaline" from 1990 to December 2015...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29441867/investigation-of-transferrin-interaction-with-medicinally-important-noble-metal-ions-using-affinity-capillary-electrophoresis
#9
H A Alhazmi, M Al Bratty, S A Javed, K G Lalitha
Transferrins (TFs) consist of a large group of glycoproteins, whose function is to transport iron across the cell membrane. Apart from iron, serum transferrin can also bind several other metal ions and hence can offer a potential route for the delivery of these metal ions into the cellular fluids. In the present study the interaction behavior of nine noble metal ions, Ag+, Au+, Au3+, Os3+, Pd2+, Pt4+, Rh3+, Ru3+ and Ir3+ with transferrin was investigated by affinity capillary electrophoresis (ACE) using the dynamic mobility shift mode...
May 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441157/oiling-the-gate-a-mobile-application-to-improve-the-admissions-process-from-the-emergency-department-to-an-academic-community-hospital-inpatient-medicine-service
#10
Russell Fung, Jensen Hart Hyde, Mike Davis
The process of admitting patients from the emergency department (ED) to an academic internal medicine (AIM) service in a community teaching hospital is one fraught with variability and disorder. This results in an inconsistent volume of patients admitted to academic versus private hospitalist services and results in frustration of both ED and AIM clinicians. We postulated that implementation of a mobile application (app) would improve provider satisfaction and increase admissions to the academic service. The app was designed and implemented to be easily accessible to ED physicians, regularly updated by academic residents on call, and a real-time source of the number of open AIM admission spots...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29426601/from-quality-markers-to-data-mining-and-intelligence-assessment-a-smart-quality-evaluation-strategy-for-traditional-chinese-medicine-based-on-quality-markers
#11
Gang Bai, Tiejun Zhang, Yuanyuan Hou, Guoyu Ding, Min Jiang, Guoan Luo
BACKGROUND: The quality of traditional Chinese medicine (TCM) forms the foundation of its clinical efficacy. The standardization of TCM is the most important task of TCM modernization. In recent years, there has been great progress in the quality control of TCM. However, there are still many issues related to the current quality standards, and it is difficult to objectively evaluate and effectively control the quality of TCM. PURPOSE: To face these challenge, we summarized the current quality marker (Q-marker) research based on its characteristics and benefits, and proposed a reasonable and intelligentized quality evaluation strategy for the development and application of Q-markers...
January 31, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29425644/ligustilide-attenuates-vascular-inflammation-and-activates-nrf2-ho-1-induction-and-no-synthesis-in-huvecs
#12
Eun Sik Choi, Jung Joo Yoon, Byung Hyuk Han, Da Hye Jeong, Yun Jung Lee, Dae Gill Kang, Ho Sub Lee
BACKGROUND: Ligustilide is a bioactive phthalide derivative isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root) which are both medicinal herbs used to treat circulatory disorders. Vascular endothelium is a central spot in developing cardiovascular diseases and chronic vascular inflammation might result in atherosclerosis development. PURPOSE: We previously found out that a traditional herbal formula, Samul-Tang (Si-Wu-Tang, containing Cnidii Rhizoma and Angelicae Gigantis Radix), attenuated vascular inflammation in human umbilical vein endothelial cells (HUVECs)...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29418009/multidisciplinary-approach-in-a-case-of-hand-sch%C3%A3-ller-christian-disease-with-maxillary-involvement
#13
Angela Pia Cazzolla, Nunzio Francesco Testa, Gianfranco Favia, Maria Grazia Lacaita, Domenico Ciavarella, Khrystyna Zhurakivska, Giuseppe Troiano, Lorenzo Lo Muzio
Langerhans cell histiocytosis (LCH) is a childhood pathology with a peak of incidence ranging from 1 to 4 years of age, though diagnosis is often made in adult age. LCH is clinically classified into three types: eosinophilic granuloma, Hand-Schuller-Christian disease and Abt-Letterer-Siwe disease. We report a case of Hand-Schüller-Christian disease with diabetes insipidus, skull and maxillary involvement in a 16-year-old boy referred to our observation for gradual increase in mobility of the teeth and subsequent gradual loss of the second premolars and the first molars of the upper jaw...
February 8, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29415614/prevalence-and-attitude-of-university-students-towards-mobile-phone-use-while-driving-in-jeddah-saudi-arabia
#14
Mukhtiar Baig, Zohair Jamil Gazzaz, Hazem Atta, Mujtaba Ahmed Alyaseen, Ammar Jameel Albagshe, Haidar Ghalib Alattallah
This study aimed to investigate the prevalence and attitude of university students towards mobile phone use while driving. The present study was conducted at King Abdulaziz University, Jeddah, Saudi Arabia. Five hundred and ninety-three participants were recruited for this study. Attitude, consequences and their involvement in various reckless behaviours pertaining to the use of mobile phone while driving were checked by a questionnaire. Overall, the majority of the respondents (90%) use a mobile phone while driving...
February 8, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29411270/haptoglobin-genotype-and-vitamin%C3%A2-e-versus-placebo-for-the-treatment-of-nondiabetic-patients-with-nonalcoholic-steatohepatitis-in-china-a-multicenter-randomized-placebo-controlled-trial-design
#15
Shufei Zang, Jin Chen, Yu Song, Lang Bai, Jinjun Chen, Xiaoling Chi, Fangping He, Huiping Sheng, Jing Wang, Shilong Xie, Wen Xie, Yongfeng Yang, Jing Zhang, Minghua Zheng, Zhengsheng Zou, Bingyuan Wang, Junping Shi
INTRODUCTION: Vitamin E is one of the most promising agents for nonalcoholic steatohepatitis (NASH) treatment, and its drug responsiveness may be closely associated with haptoglobin (Hp) genotype. However, its efficacy and safety remain unknown in China. This clinical trial of vitamin E versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis (VENS) is conducted to evaluate (a) the efficacy and safety of treatment with vitamin E softgel (300 mg/day) determined from standardized histologic scoring of liver biopsies, (b) whether treatment with vitamin E improves biochemical parameters, cytokines, anthropometric parameters, controlled attenuation parameter (CAP), and transient elastography (TE) values determined by Fibroscan and health-related quality of life (SF-36), (c) whether the efficacy of vitamin E treatment is associated with the Hp genotype in nondiabetic adults with NASH...
February 6, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29408799/the-case-for-a-distinctive-philosophy-of-physiology-and-pathophysiology
#16
Hutan Ashrafian
What is an organ and what is an organ system? According to the 'standard' hierarchical model of physiology, each living organism comprises of organ systems including those that offer sensory and control functions (nervous system), energy accumulation (gastrointestinal system), internal dissipation (circulatory system) and mobility (musculoskeletal system). Each organ system in turn is comprised of individual organs. This taxonomy has conceptual flaws as not every organ has a single organ system function but may participate in a myriad of physiological functions...
February 6, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29408710/delayed-release-of-chemokine-ccl25-with-bioresorbable-microparticles-for-mobilization-of-human-mesenchymal-stem-cells
#17
Kristin Fröhlich, David Hartzke, Franziska Schmidt, Jan Eucker, Aleksander Gurlo, Michael Sittinger, Jochen Ringe
Chemokines are guiding cues for directional trafficking of mesenchymal stem cells (MSC) upon injury and local chemokine delivery at injury sites is an up-to-date strategy to potentiate and prolong recruitment of MSC. In this study we present the chemokine CCL25, also referred to as thymus-expressed chemokine, to mobilize human MSC along positive but not along negative gradients. We hence proceeded to design a biodegradable and injectable release device for CCL25 on the basis of poly(lactic-co-glycolic acid) (PLGA)...
February 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29404041/identification-and-characterization-of-phenolics-and-terpenoids-from-ethanolic-extracts-of-phyllanthus-species-by-hplc-esi-qtof-ms-ms
#18
Sunil Kumar, Awantika Singh, Brijesh Kumar
Phyllanthus species plants are a rich source of phenolics and widely used due to their medicinal properties. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed using high-pressure liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-ESI-QTOF-MS/MS) for the identification and characterization of quercetin, kaempferol, ellagic acid and their derivatives in ethanolic extracts of Phyllanthus species. The chromatographic separation was carried out on Thermo Betasil C8 column (250 mm×4...
August 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29401732/evaluation-of-the-effectiveness-of-acupuncture-in-the-treatment-of-knee-osteoarthritis-a-case-study
#19
Joana Teixeira, Maria João Santos, Luís Carlos Matos, Jorge Pereira Machado
Background: Osteoarthritis is a widespread chronic disease seen as a continuum of clinical occurrences within several phases, which go from synovial inflammation and microscopic changes of bone and cartilage to painful destructive changes of all the joint structures. Being the most common joint disease, it is the leading cause of disability in working individuals above 50 years of age. In some cases, conventional treatments produce just a mild and brief pain reduction and have considerable side-effects. Contemporary Traditional Chinese Medicine (TCM) is a model of systems biology based on a logically accessible theoretical background...
February 5, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29393688/systematic-review-of-high-level-mobility-training-in-people-with-a-neurological-impairment
#20
Tanja Spencer, Sara Aldous, Gavin Williams, Michael Fahey
AIM: The objective of this paper was to systematically review the efficacy of interventions targeting high-level mobility skills in people with a neurological impairment. METHODS: A comprehensive electronic database search was conducted. Study designs were graded using the American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) system and methodological quality was described using the Physiotherapy Evidence Database (PEDro) scale. RESULTS: Twelve exploratory studies (AACPDM levels IV/V), of limited methodological quality (PEDro scores of 2-3 out of 10), were included...
February 2, 2018: Brain Injury: [BI]
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