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JOURNAL ARTICLE
Jonathan Koea, Phillip Chao, Sanket Srinivasa, Jason Gurney
INTRODUCTION: New Zealand has a population of only 5.5 million meaning that for many surgical procedures the country qualifies as a "low-volume center." However, the health system is well developed and required to provide complex surgical procedures that benchmark internationally against comparable countries. This investigation was undertaken to review regional variation and volumes of complex resection and palliative upper gastrointestinal (UGI) surgical procedures within New Zealand...
April 12, 2024: World Journal of Surgery
#2
JOURNAL ARTICLE
Venkateswarlu Chamcha, Li He, Jenny Xu, Andrew R Swartz, Erin Green-Trexler, Kevin Gurney, Tessie McNeely
Oncolytic viruses (OV) are part of a burgeoning field of investigational oncolytic therapy (OT), in which lytic viruses dissolve advanced tumors productively and specifically. One such OT is a Coxsackievirus A21 (CVA21) based OV that is currently under clinical evaluation. A tissue culture infectious dose (TCID50) assay was used for CVA21 potency release and stability testing in early clinical development. The titer measured in this method was an extrapolated value from cytopathic effect (CPE) observed during the serial dilution but doesn't represent direct viral killing of cells...
April 15, 2024: Heliyon
#3
REVIEW
Michael H Wong, Naomi Rowe-Gurney, Stephen Markham, Kunio M Sayanagi
A major motivation for multiple atmospheric probe measurements at Uranus is the understanding of dynamic processes that create and maintain spatial variation in thermal structure, composition, and horizontal winds. But origin questions-regarding the planet's formation and evolution, and conditions in the protoplanetary disk-are also major science drivers for multiprobe exploration. Spatial variation in thermal structure reveals how the atmosphere transports heat from the interior, and measuring compositional variability in the atmosphere is key to ultimately gaining an understanding of the bulk abundances of several heavy elements...
2024: Space Science Reviews
#4
JOURNAL ARTICLE
Allison Aripoli, Madeleine Gurney, Rebecca Flynn Sourk, Ryan Ash, Christopher M Walker, Jessica Peterson, Ashley Huppe, Camron Smith, Carissa Walter, Lauren Clark, Onalisa Winblad
OBJECTIVE: Closed Loop Imaging Programs (CLIP) are designed to ensure that patients receive appropriate follow-up, however, review of incidental CT-detected breast findings in the setting of CLIPs has not been performed. METHODS: A retrospective review was conducted of CT reports at a single academic institution from 7/1/2020 to 1/31/2022 to identify reports with recommendation for breast imaging follow-up. Medical records were reviewed to evaluate patient adherence to follow-up, CLIP intervention, subsequent BI-RADS assessment, and diagnosis...
January 12, 2024: Journal of the American College of Radiology: JACR
#5
JOURNAL ARTICLE
Eve S Shalom, Harrison Kim, Rianne A van der Heijden, Zaki Ahmed, Reyna Patel, David A Hormuth, Julie C DiCarlo, Thomas E Yankeelov, Nicholas J Sisco, Richard D Dortch, Ashley M Stokes, Marianna Inglese, Matthew Grech-Sollars, Nicola Toschi, Prativa Sahoo, Anup Singh, Sanjay K Verma, Divya K Rathore, Anum S Kazerouni, Savannah C Partridge, Eve LoCastro, Ramesh Paudyal, Ivan A Wolansky, Amita Shukla-Dave, Pepijn Schouten, Oliver J Gurney-Champion, Radovan Jiřík, Ondřej Macíček, Michal Bartoš, Jiří Vitouš, Ayesha Bharadwaj Das, S Gene Kim, Louisa Bokacheva, Artem Mikheev, Henry Rusinek, Michael Berks, Penny L Hubbard Cristinacce, Ross A Little, Susan Cheung, James P B O'Connor, Geoff J M Parker, Brendan Moloney, Peter S LaViolette, Samuel Bobholz, Savannah Duenweg, John Virostko, Hendrik O Laue, Kyunghyun Sung, Ali Nabavizadeh, Hamidreza Saligheh Rad, Leland S Hu, Steven Sourbron, Laura C Bell, Anahita Fathi Kazerooni
PURPOSE: <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:semantics><mml:mrow><mml:msup><mml:mi>K</mml:mi> <mml:mtext>trans</mml:mtext></mml:msup> </mml:mrow> <mml:annotation>$$ {K}^{\mathrm{trans}} $$</mml:annotation></mml:semantics> </mml:math> has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for <mml:math xmlns:mml="https://www...
December 19, 2023: Magnetic Resonance in Medicine
#6
JOURNAL ARTICLE
Asmail A M Abdalkarem, Roaa Ansaf, Wan Khairul Muzammil, Adnan Ibrahim, Zambri Harun, Ahmad Fazlizan
The airfoil blade is the primary component of a wind turbine, and its aerodynamic properties play a crucial role in determining the energy conversion efficiency of these blades. Many researchers have proposed different airfoil modifications intending to enhance the aerodynamic characteristics and limit the unsteady interaction with the atmospheric boundary layer. This study evaluates the benefits of mounting wedge tails (WTs) on the trailing edge of an airfoil. The aerodynamic characteristics of a 2-D, steady-state NACA 0021 airfoil featuring the wedge tails (WT) and fish wedge tails (FWT) were studied computationally by employing the shear stress transport (SST) k-ω turbulence model...
November 2023: Heliyon
#7
JOURNAL ARTICLE
Evan Y Yu, William R Berry, Howard Gurney, Margitta Retz, Henry J Conter, Brigitte Laguerre, Peter C C Fong, Cristiano Ferrario, Tilman Todenhöfer, Gwenaelle Gravis, Josep M Piulats, Urban Emmenegger, Neal D Shore, Emanuela Romano, Loic Mourey, Xin Tong Li, Christian H Poehlein, Charles Schloss, Leonard J Appleman, Johann S de Bono
BACKGROUND: Limited responses have been observed in patients treated with enzalutamide after disease progression on abiraterone for metastatic castration-resistant prostate cancer (mCRPC), but androgen receptor signaling impacts T-cell function. OBJECTIVE: To evaluate the efficacy and safety of pembrolizumab plus enzalutamide in mCRPC. DESIGN, SETTING, AND PARTICIPANTS: Patients in cohort C of the phase 1b/2 KEYNOTE-365 study, who received ≥4 wk of treatment with abiraterone acetate in the prechemotherapy mCRPC state and experienced treatment failure or became drug-intolerant, were included...
November 6, 2023: European Urology Oncology
#8
JOURNAL ARTICLE
Shauna L Mahajan, Samson Obiene, Lenice Ojwang, Nasser Olwero, Abel Valdivia, Adaoma Wosu, Emily Adrid, Dominic A Andradi-Brown, Gildas Andriamalala, Natalie C Ban, Nathan J Bennett, Jessica Blythe, Samantha H Cheng, Emily Darling, Matheus De Nardo, Elizabeth DruryO'Neill, Graham Epstein, Robert Y Fidler, Kim Fisher, Jonas Geldmann, David A Gill, Rachel Golden Kroner, Georgina Gurney, Arundhati Jagadish, Harry D Jonas, Muhammad Erdi Lazuardi, Samantha Petersen, Valencia V Ranarivelo, Lilia Rasoloformanana, Tojo M Rasolozaka, Daniel J Read, Elia Sabula Mwaiteleke, Gabby Ahmadia
Monitoring the governance and management effectiveness of area-based conservation has long been recognized as an important foundation for achieving national and global biodiversity goals and enabling adaptive management. However, there are still many barriers that prevent conservation actors, including those impacted by governance and management systems and/or implementing conservation activities and programs, from gathering and using data on governance and management to inform decision-making across spatial scales and through time...
October 30, 2023: Conservation Biology
#9
REVIEW
Toni K Choueiri, Thomas Powles, Martin H Voss, Elizabeth R Plimack, Howard Gurney, Yue Song, Rodolfo F Perini, Karla Rodriguez-Lopez, Brian I Rini
Combination treatment with immunotherapy agents and/or vascular endothelial growth factor tyrosine kinase inhibitors are a standard of care for patients with advanced clear cell renal cell carcinoma (ccRCC). Novel therapeutic combinations that include the hypoxia-inducible factor 2α inhibitor belzutifan and the cytotoxic T-lymphocyte-associated protein 4 inhibitor quavonlimab are being investigated for their potential to further improve patient outcomes. This protocol describes the rationale and design of the randomized, phase III LITESPARK-012 study, which will evaluate the efficacy and safety of pembrolizumab plus lenvatinib with or without belzutifan or quavonlimab as first-line treatment for advanced ccRCC...
December 2023: Future Oncology
#10
JOURNAL ARTICLE
Natalie C Ban, Emily S Darling, Georgina G Gurney, Whitney Friedman, Stacy D Jupiter, W Peni Lestari, Irfan Yulianto, Sinta Pardede, Sukma A R Tarigan, Puji Prihatiningsih, Sangeeta Mangubhai, Waisea Naisilisili, Sirilo Dulunaqio, Josheena Naggea, Ravaka Ranaivoson, Vera N Agostini, Gabby Ahmadia, Jessica Blythe, Stuart J Campbell, Joachim Claudet, Courtney Cox, Graham Epstein, Estradivari Estradivari, Margaret Fox, David Gill, Amber Himes-Cornell, Harry Jonas, Elizabeth Mcleod, Nyawira A Muthiga, Tim McClanahan
Understanding the relative effectiveness and enabling conditions of different area-based management tools is essential for supporting efforts that achieve positive biodiversity outcomes as area-based conservation coverage increases to meet newly set international targets. We used data from a coastal social-ecological monitoring program in six Indo-Pacific countries to analyze whether social, ecological, and economic objectives and specific management rules (temporal closures, fishing gear-, species-specific restrictions) were associated with coral reef fish biomass above sustainable yield levels across different types of area-based management tools (i...
September 20, 2023: Conservation Biology
#11
JOURNAL ARTICLE
Jordan L Fox, Thomas D Doolan, Tiana M Gurney, Matthew R McGrail
INTRODUCTION: Little is known about how medical school placements in rural areas impact key stakeholders such as patients, host organisations and the wider rural community. With engagement from rural communities crucial to the success of rural medical training, this case study sought to demonstrate the benefit that rural clinical placements can have on rural general practices (systems) and likely impacts on communities (health outcomes). Specifically, we describe how a series of consecutive short-term student placements in a single rural practice were the drivers of a series of clinical audits and interventions resulting in improved management of chronic disease...
April 2023: Rural and Remote Health
#12
JOURNAL ARTICLE
Tom Gurney, James Brouner, Owen Spendiff
This study investigated the effects of chlorella supplementation on submaximal endurance, time trial performance, lactate threshold, and power indices during a repeated sprint performance test by fourteen male trained cyclists. Participants ingested 6 g/day of chlorella or placebo for 21-days in a double-blinded randomized counter-balanced cross-over design, with a fourteen-day washout period between trials. Each completed a 2-day testing period comprising a 1-hour submaximal endurance test at 55% external power output max and a 16...
March 11, 2023: Journal of Dietary Supplements
#13
JOURNAL ARTICLE
Jay B Baker, Sean Keenan, Teresa A Duquette-Frame, Russ Kotwal, Andrew S Harvey, Andrew P Cap, Stacy A Shackelford, Jennifer M Gurney
INTRODUCTION: In recent conflicts, the Joint Theater Trauma System (JTTS) led the systematic approach to improve battlefield trauma care, substantially contributing to the unprecedented survival of combat casualties. The Joint Trauma System (JTS) was codified in 2016 to preserve the lessons learned and functions of the JTTS, including the Department of Defense Trauma Registry. Concurrently, Combatant Commands (CCMD) were directed to establish CCMD Trauma Systems (CTS) "modeled after the JTTS" and to maintain a baseline of core functions intended to rapidly scale as needed...
February 25, 2023: Military Medicine
#14
JOURNAL ARTICLE
Mengjia Feng, Yu Feng, Changhai Zhang, Tiandong Zhang, Qingguo Chen, Qingguo Chi
Improving the tolerance of flexible polymers to extreme temperatures and electrical fields is critical to the development of advanced electrical and electronic systems. Suppressing carrier movement at high temperatures is one of the key methods to improve the high-temperature charging and discharging efficiency. In this work, a molecular semiconductor (ITIC) with high electron affinity energy is blended into the promising polymer polyetherimide (PEI). This molecular semiconductor will introduce traps in the dielectric that can trap carriers, thus achieving the effect of inhibiting carrier movement...
September 21, 2022: Materials Horizons
#15
JOURNAL ARTICLE
Pamela B Andreatta, John Christopher Graybill, Christopher H Renninger, Robert K Armstrong, Mark W Bowyer, Jennifer M Gurney
INTRODUCTION: In deployed contexts, military medical care is provided through the coordinated efforts of multiple interdisciplinary teams that work across and between a continuum of widely distributed role theaters. The forms these teams take, and functional demands, vary by roles of care, location, and mission requirements. Understanding the requirements for optimal performance of these teams to provide emergency, urgent, and trauma care for multiple patients simultaneously is critical...
September 19, 2022: Military Medicine
#16
JOURNAL ARTICLE
Evan Y Yu, Josep M Piulats, Gwenaelle Gravis, Peter C C Fong, Tilman Todenhöfer, Brigitte Laguerre, Jose A Arranz, Stephane Oudard, Christophe Massard, Julia Heinzelbecker, Luke T Nordquist, Joan Carles, Michael P Kolinsky, Marinela Augustin, Howard Gurney, Ali Tafreshi, Xin Tong Li, Ping Qiu, Christian H Poehlein, Charles Schloss, Johann S de Bono
BACKGROUND: Pembrolizumab and olaparib have shown single-agent activity in patients with previously treated metastatic castration-resistant prostate cancer (mCRPC). OBJECTIVE: To evaluate the efficacy and safety of pembrolizumab plus olaparib in mCRPC. DESIGN, SETTING, AND PARTICIPANTS: Cohort A of the phase 1b/2 KEYNOTE-365 study enrolled patients with molecularly unselected, docetaxel-pretreated mCRPC whose disease progressed within 6 mo of screening...
January 2023: European Urology
#17
REVIEW
Michelle Mako, Jason Gurney, Moahia Goza, Myra Ruka, Nina Scott, Gary Thompson, Diana Sarfati
The purpose of this manuscript was to consider how mainstream health organisations can develop structures, processes, and functions to address inequity, using the New Zealand Cancer Control Agency (Te Aho o Te Kahu) as an example. In New Zealand (Aotearoa), as in other countries, inequities in cancer incidence and outcomes exist between population groups, including for indigenous populations. Despite much discussion regarding the need to address racial inequities, often the proposed solutions are at operational or programmatic levels, and disadvantaged communities are unable to have much of a say in the system design and service delivery of these solutions...
September 2022: Lancet Oncology
#18
RANDOMIZED CONTROLLED TRIAL
Thomas Powles, Piotr Tomczak, Se Hoon Park, Balaji Venugopal, Thomas Ferguson, Stefan N Symeonides, Jaroslav Hajek, Howard Gurney, Yen-Hwa Chang, Jae Lyun Lee, Naveed Sarwar, Antoine Thiery-Vuillemin, Marine Gross-Goupil, Mauricio Mahave, Naomi B Haas, Piotr Sawrycki, Joseph E Burgents, Lei Xu, Kentaro Imai, David I Quinn, Toni K Choueiri
BACKGROUND: The first interim analysis of the KEYNOTE-564 study showed improved disease-free survival with adjuvant pembrolizumab compared with placebo after surgery in patients with clear cell renal cell carcinoma at an increased risk of recurrence. The analysis reported here, with an additional 6 months of follow-up, was designed to assess longer-term efficacy and safety of pembrolizumab versus placebo, as well as additional secondary and exploratory endpoints. METHODS: In the multicentre, randomised, double-blind, placebo-controlled, phase 3 KEYNOTE-564 trial, adults aged 18 years or older with clear cell renal cell carcinoma with an increased risk of recurrence were enrolled at 213 hospitals and cancer centres in North America, South America, Europe, Asia, and Australia...
September 2022: Lancet Oncology
#19
JOURNAL ARTICLE
A C Ryan, J C Murrell, M A Gurney
Opioids are a key component of multimodal analgesia. Methadone is licensed in Europe for IV, IM and SC use in dogs despite there being no published studies assessing the analgesic efficacy of SC administration. Our intention was to compare the analgesic effect of IV or SC methadone. Fifteen dogs presenting for stifle surgery were administered 0.4mg/kg methadone IV followed by a randomised 0.4mg/kg methadone IV or SC dose 3h later. All dogs received ultrasound-guided sciatic and saphenous nerve blocks with bupivacaine prior to surgery...
July 25, 2022: Veterinary Journal
#20
JOURNAL ARTICLE
Jennifer M Gurney, Sarah K John, Edward H Whitt, Bryce J Slinger, William P Luan, Jamie Lindly, Johnathan Christopher Graybill, Jeffrey A Bailey
BACKGROUND: Between conflicts, many of the combat casualty care lessons learned are lost as the nation shifts priorities and providers leave the military. Solutions are needed to bridge the knowledge gap created by interwar periods. One of the foremost solutions is partnerships between civilian trauma centers and the military health system. Over the past two decades, a myriad of military-civilian partnerships (MCPs), which vary in their composition, duration, and focus, was created. The objective of this report is to describe the initial attempt of the Department of Defense to catalog existing MCPs to inform both civilian and military stakeholders...
August 1, 2022: Journal of Trauma and Acute Care Surgery
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