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Gurney design

Sebastian S James, Chris Papapavlou, Alexander Blenkinsop, Alexander J Cope, Sean R Anderson, Konstantinos Moustakas, Kevin N Gurney
To date, realistic models of how the central nervous system governs behavior have been restricted in scope to the brain, brainstem or spinal column, as if these existed as disembodied organs. Further, the model is often exercised in relation to an in vivo physiological experiment with input comprising an impulse, a periodic signal or constant activation, and output as a pattern of neural activity in one or more neural populations. Any link to behavior is inferred only indirectly via these activity patterns...
2018: Frontiers in Neuroscience
Bo Gao, Yi Lu, Annemieke J M Nieuweboer, Hongmei Xu, Jonathan Beesley, Ingrid Boere, Anne-Joy M de Graan, Peter de Bruijn, Howard Gurney, Catherine J Kennedy, Yoke-Eng Chiew, Sharon E Johnatty, Philip Beale, Michelle Harrison, Craig Luccarini, Don Conroy, Ron H J Mathijssen, Paul R Harnett, Rosemary L Balleine, Georgia Chenevix-Trench, Stuart Macgregor, Anna de Fazio
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition, limiting patient recruitment. We found that carboplatin and paclitaxel disposition are stable phenotypes in ovarian cancer patients and tested a genome-wide association study (GWAS) design to identify SNPs associated with chemotherapy disposition...
January 24, 2018: Scientific Reports
Olivia Hewitt, Ben Gurney-Smith, Kim Golding
Children who are adopted have frequently experienced a range of aversive experience which impact on their ability to form secure attachments. Dyadic Developmental Psychotherapy (DDP) is an intervention designed to develop and promote secure attachments with children who have experienced developmental trauma. Eight adoptive parents participated in semi-structured interviews regarding their experiences of attending the 'Nurturing Attachment' group informed by DDP. The transcripts of their interviews were explored using Interpretative Phenomenological Analysis...
January 1, 2018: Clinical Child Psychology and Psychiatry
Jorge G Álvarez-Romero, Adrián Munguía-Vega, Maria Beger, Maria Del Mar Mancha-Cisneros, Alvin N Suárez-Castillo, Georgina G Gurney, Robert L Pressey, Leah R Gerber, Hem Nalini Morzaria-Luna, Héctor Reyes-Bonilla, Vanessa M Adams, Melanie Kolb, Erin M Graham, Jeremy VanDerWal, Alejandro Castillo-López, Gustavo Hinojosa-Arango, David Petatán-Ramírez, Marcia Moreno-Baez, Carlos R Godínez-Reyes, Jorge Torre
Marine reserves are widely used to protect species important for conservation and fisheries and to help maintain ecological processes that sustain their populations, including recruitment and dispersal. Achieving these goals requires well-connected networks of marine reserves that maximize larval connectivity, thus allowing exchanges between populations and recolonization after local disturbances. However, global warming can disrupt connectivity by shortening potential dispersal pathways through changes in larval physiology...
February 2018: Global Change Biology
Miguelina Germán, Michael L Rinke, Brittany A Gurney, Rachel S Gross, Diane E Bloomfield, Lauren A Haliczer, Silvie Colman, Andrew D Racine, Rahil D Briggs
This study examined how to design, staff, and evaluate the feasibility of 2 different models of integrated behavioral health programs in pediatric primary care across primary care sites in the Bronx, NY. Results suggest that the Behavioral Health Integration Program model of pediatric integrated care is feasible and that hiring behavioral health staff with specific training in pediatric, evidence-informed behavioral health treatments may be a critical variable in increasing outcomes such as referral rates, self-reported competency, and satisfaction...
October 2017: Child and Adolescent Psychiatric Clinics of North America
Jason K Gurney, Uwe G Kersting, Dieter Rosenbaum, Ajith Dissanayake, Steve York, Roger Grech, Anthony Ng, Bobbie Milne, James Stanley, Diana Sarfati
BACKGROUND: The peripheral complications of diabetes mellitus remain a significant risk to lower-limb morbidity. In New Zealand, risk of diabetes, comorbidity and lower-limb amputation are highly-differential between demographic groups, particularly ethnicity. There is growing and convincing evidence that the use of pedobarography - or plantar pressure measurement - can usefully inform diabetic foot care, particularly with respect to the prevention of re-ulceration among high-risk patients...
2017: Journal of Foot and Ankle Research
L E Heiniger, A B Smith, I Olver, P Grimison, B Klein, A Wootten, J-A M Abbott, M A Price, M McJannett, B Tran, M R Stockler, H Gurney, P N Butow
e-TC is an online intervention designed to address common psychosocial concerns of testicular cancer survivors. It aims to reduce anxiety, depression and fear of cancer recurrence by providing evidence-based information and psychological intervention. This paper details the development and pilot testing of e-TC. During pilot testing, 25 men (with varying psychological profiles) who had completed treatment for testicular cancer, 6 months to 5 years ago (which had not recurred), used e-TC over a 10-week period and provided quantitative and qualitative feedback on the feasibility and acceptability of the programme...
May 22, 2017: European Journal of Cancer Care
Sebastian James, Olivia A Bell, Muhammed A M Nazli, Rachel E Pearce, Jonathan Spencer, Katie Tyrrell, Phillip J Paine, Timothy J Heaton, Sean Anderson, Mauro Da Lio, Kevin Gurney
The study of action selection in humans can present challenges of task design since our actions are usually defined by many degrees of freedom and therefore occupy a large action-space. While saccadic eye-movement offers a more constrained paradigm for investigating action selection, the study of reach-and-grasp in upper limbs has often been defined by more complex scenarios, not easily interpretable in terms of such selection. Here we present a novel motor behaviour task which addresses this by limiting the action space to a single degree of freedom in which subjects have to track (using a stylus) a vertical coloured target line displayed on a tablet computer, whilst ignoring a similarly oriented distractor line in a different colour...
2017: PloS One
Andrew Rowland, Madelé van Dyk, Arduino A Mangoni, John O Miners, Ross A McKinnon, Michael D Wiese, Angela Rowland, Ganessan Kichenadasse, Howard Gurney, Michael J Sorich
Small molecule protein kinase inhibitors (KIs) are a class of drugs with complex and unconventional physiochemical and pharmacokinetic characteristics. Cytochrome P450 mediated metabolism and transporter-mediated uptake and efflux are important processes that determine KI disposition and exposure. Areas covered: We provide an overview of KI pharmacology, with a comprehensive summary of KI physiochemical and pharmacokinetic properties and description of the major sources of variability in KI pharmacokinetics focusing on common pathways involved in determining exposure...
January 2017: Expert Opinion on Drug Metabolism & Toxicology
B C Presley, S M R Gurney, K S Scott, S L Kacinko, B K Logan
Synthetic cannabinoids, which began proliferating in the United States in 2009, have gone through numerous iterations of modification to their chemical structures. More recent generations of compounds have been associated with significant adverse outcomes following use, including cognitive and psychomotor impairment, seizures, psychosis, tissue injury and death. These effects increase the urgency for forensic and public health laboratories to develop methods for the detection and identification of novel substances, and apply these to the determination of their metabolism and disposition in biological samples...
July 2016: Forensic Science Review
A Burke Gurney, Christine Mermier, Michael LaPlante, Aditi Majumdar, Kathleen O'Neill, Todd Shewman, James G Gurney
Study Design Controlled laboratory study. Background The activity of the rotator cuff muscles has not previously been measured with indwelling electromyography (EMG) comparing ambulation and other movements. Knowledge of the relative contribution of these muscles during various tasks may help to guide rehabilitation progression. Objective To measure activity of the rotator cuff muscles and other shoulder muscles during normal ambulation, shirt and sling donning and doffing, and rehabilitation tasks commonly performed after rotator cuff surgery...
May 2016: Journal of Orthopaedic and Sports Physical Therapy
Robert Gurney
Purpose - The purpose of this paper is to fill an apparent gap in the literature addressing issues of leadership and change - the development and activities of constructing and leading sports sciences and medicine professions, and similarly, the construction and leadership of multidisciplinary/inter-disciplinary organisations that practice sports sciences and medicine. Design/methodology/approach - This study incorporated explorations through conducting both interviews and survey questionnaires with members of Sports Medicine Australia (SMA)...
2016: Leadership in Health Services
Michael L Gurney, Stanley D Sharples, Wesley B Phillips, Damian J Lee
STATEMENT OF PROBLEM: The use of lasers is growing widely in dentistry. Despite its clinical implications, most information and clinical data related to the removal of ceramic restorations with the aid of a laser is either anecdotal or in the form of clinical reports. PURPOSE: The purpose of this in vitro study was to establish a parameter on the removal of lithium disilicate crowns with a laser and conduct an in vitro trial of crown removal based on the wattage and time of application...
January 2016: Journal of Prosthetic Dentistry
Georgina G Gurney, Robert L Pressey, Joshua E Cinner, Richard Pollnac, Stuart J Campbell
Despite the prevalence of protected areas, evidence of their impacts on people is weak and remains hotly contested in conservation policy. A key question in this debate is whether socioeconomic impacts vary according to social subgroup. Given that social inequity can create conflict and impede poverty reduction, understanding how protected areas differentially affect people is critical to designing them to achieve social and biological goals. Understanding heterogeneous responses to protected areas can improve targeting of management activities and help elucidate the pathways through which impacts of protected areas occur...
November 5, 2015: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A Kearns, B Gurney, P Johnson
Accurate orthognathic wafers manufactured in the laboratory are essential for the transfer of preoperative prescribed movements to theatre, and most are made of poly(methyl methacrylate) (PMMA). At the Royal Surrey County Hospital we used 416 silicone wafers in 292 patients from January 2011 to December 2013. We report how a revised design has improved self-retention and intraoperative visualisation.
December 2015: British Journal of Oral & Maxillofacial Surgery
Samantha Karr, Mary K Gurney, Nicole K Early
OBJECTIVES: To examine the accuracy of a community-based blood pressure monitor (CBPM) versus a validated automatic blood pressure monitor (ABPM); to assess providers' recommendations regarding use of CBPMs; and to assess if potentially inaccurate blood pressure readings may result in treatment changes. METHODS: A convenience sample of 50 participants was recruited and met criteria for a randomized, controlled, crossover design trial in a community pharmacy in January and February 2013...
July 2015: Journal of the American Pharmacists Association: JAPhA
Christopher J Marshall, David A Lytle
Grylloblatta rothi Gurney, 1953 is redescribed and a neotype is designated from Cultus Mountain in the Oregon Cascades, U.S.A. Two new species of Grylloblatta are described, bringing the total number of Grylloblatta species to 15. Grylloblatta chintimini new species is described from Marys Peak in the Coast Range of Western Oregon, where it occurs on snowpack near the 1250 m summit. Grylloblatta newberryensis new species is described from Newberry Volcano in Central Oregon, where it is associated with snowfields overlying geologically-young lava flows...
April 29, 2015: Zootaxa
Georgina G Gurney, Robert L Pressey, Natalie C Ban, Jorge G Álvarez-Romero, Stacy Jupiter, Vanessa M Adams
The efficacy of protected areas varies, partly because socioeconomic factors are not sufficiently considered in planning and management. Although integrating socioeconomic factors into systematic conservation planning is increasingly advocated, research is needed to progress from recognition of these factors to incorporating them effectively in spatial prioritization of protected areas. We evaluated 2 key aspects of incorporating socioeconomic factors into spatial prioritization: treatment of socioeconomic factors as costs or objectives and treatment of stakeholders as a single group or multiple groups...
October 2015: Conservation Biology: the Journal of the Society for Conservation Biology
Michael R Deyhle, Hung-Sheng Hsu, Timothy J Fairfield, Taryn L Cadez-Schmidt, Burke A Gurney, Christine M Mermier
Little research is available to guide training programs for rock climbers. To help meet this need, we sought to determine the relative importance of 4 muscle groups for rock climbing performance. Eleven male climbers were familiarized with an indoor climbing route before 5 separate days of testing. On testing days, subjects were randomly assigned to climb with no prefatiguing exercise (control climb) or after a prefatiguing exercise designed to specifically target the digit flexors (DF), shoulder adductors (SA), elbow flexors (EF), or lumbar flexors (LF)...
July 2015: Journal of Strength and Conditioning Research
Cheryl Cero, Vitaly V Vostrikov, Raffaello Verardi, Cinzia Severini, Tata Gopinath, Patrick D Braun, Maria F Sassano, Allison Gurney, Bryan L Roth, Lucy Vulchanova, Roberta Possenti, Gianluigi Veglia, Alessandro Bartolomucci
TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-associated disorders. TLQP-21 is found in the sympathetic nerve terminals in the adipose tissue and targets the G-protein-coupled receptor complement-3a receptor1 (C3aR1). The mechanisms of TLQP-21-induced receptor activation remain unexplored. Here, we report that TLQP-21 is intrinsically disordered and undergoes a disorder-to-order transition, adopting an α-helical conformation upon targeting cells expressing the C3aR1. We determined that the hot spots for TLQP-21 are located at the C terminus, with mutations in the last four amino acids progressively reducing the bioactivity and, a single site mutation (R21A) or C-terminal amidation abolishing its function completely...
December 2, 2014: Structure
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