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Gurney design

Andrew Rowland, Madelé van Dyk, Arduino A Mangoni, John O Miners, Ross A McKinnon, Michael D Wiese, Angela Rowland, Ganessan Kichenadasse, Howard Gurney, Michael J Sorich
INTRODUCTION: Small molecule protein kinase inhibitors (KIs) are a class of drugs with complex and unconventional physiochemical and pharmacokinetic characteristics. Cytochrome P450 mediated metabolism and transporter-mediated uptake and efflux are important processes that determine KI disposition and exposure. AREAS COVERED: We provide an overview of KI pharmacology, with a comprehensive summary of KI physiochemical and pharmacokinetic properties and description of the major sources of variability in KI pharmacokinetics focusing on common pathways involved in determining exposure...
August 26, 2016: Expert Opinion on Drug Metabolism & Toxicology
B C Presley, S M R Gurney, K S Scott, S L Kacinko, B K Logan
Synthetic cannabinoids, which began proliferating in the United States in 2009, have gone through numerous iterations of modification to their chemical structures. More recent generations of compounds have been associated with significant adverse outcomes following use, including cognitive and psychomotor impairment, seizures, psychosis, tissue injury and death. These effects increase the urgency for forensic and public health laboratories to develop methods for the detection and identification of novel substances, and apply these to the determination of their metabolism and disposition in biological samples...
July 2016: Forensic Science Review
A Burke Gurney, Christine Mermier, Michael LaPlante, Aditi Majumdar, Kathleen O'Neill, Todd Shewman, James G Gurney
Study Design Controlled laboratory study. Background The activity of the rotator cuff muscles has not previously been measured with indwelling electromyography (EMG) comparing ambulation and other movements. Knowledge of the relative contribution of these muscles during various tasks may help to guide rehabilitation progression. Objective To measure activity of the rotator cuff muscles and other shoulder muscles during normal ambulation, shirt and sling donning and doffing, and rehabilitation tasks commonly performed after rotator cuff surgery...
May 2016: Journal of Orthopaedic and Sports Physical Therapy
Robert Gurney
Purpose - The purpose of this paper is to fill an apparent gap in the literature addressing issues of leadership and change - the development and activities of constructing and leading sports sciences and medicine professions, and similarly, the construction and leadership of multidisciplinary/inter-disciplinary organisations that practice sports sciences and medicine. Design/methodology/approach - This study incorporated explorations through conducting both interviews and survey questionnaires with members of Sports Medicine Australia (SMA)...
2016: Leadership in Health Services
Michael L Gurney, Stanley D Sharples, Wesley B Phillips, Damian J Lee
STATEMENT OF PROBLEM: The use of lasers is growing widely in dentistry. Despite its clinical implications, most information and clinical data related to the removal of ceramic restorations with the aid of a laser is either anecdotal or in the form of clinical reports. PURPOSE: The purpose of this in vitro study was to establish a parameter on the removal of lithium disilicate crowns with a laser and conduct an in vitro trial of crown removal based on the wattage and time of application...
January 2016: Journal of Prosthetic Dentistry
Georgina G Gurney, Robert L Pressey, Joshua E Cinner, Richard Pollnac, Stuart J Campbell
Despite the prevalence of protected areas, evidence of their impacts on people is weak and remains hotly contested in conservation policy. A key question in this debate is whether socioeconomic impacts vary according to social subgroup. Given that social inequity can create conflict and impede poverty reduction, understanding how protected areas differentially affect people is critical to designing them to achieve social and biological goals. Understanding heterogeneous responses to protected areas can improve targeting of management activities and help elucidate the pathways through which impacts of protected areas occur...
November 5, 2015: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
A Kearns, B Gurney, P Johnson
Accurate orthognathic wafers manufactured in the laboratory are essential for the transfer of preoperative prescribed movements to theatre, and most are made of poly(methyl methacrylate) (PMMA). At the Royal Surrey County Hospital we used 416 silicone wafers in 292 patients from January 2011 to December 2013. We report how a revised design has improved self-retention and intraoperative visualisation.
December 2015: British Journal of Oral & Maxillofacial Surgery
Samantha Karr, Mary K Gurney, Nicole K Early
OBJECTIVES: To examine the accuracy of a community-based blood pressure monitor (CBPM) versus a validated automatic blood pressure monitor (ABPM); to assess providers' recommendations regarding use of CBPMs; and to assess if potentially inaccurate blood pressure readings may result in treatment changes. METHODS: A convenience sample of 50 participants was recruited and met criteria for a randomized, controlled, crossover design trial in a community pharmacy in January and February 2013...
July 2015: Journal of the American Pharmacists Association: JAPhA
Christopher J Marshall, David A Lytle
Grylloblatta rothi Gurney, 1953 is redescribed and a neotype is designated from Cultus Mountain in the Oregon Cascades, U.S.A. Two new species of Grylloblatta are described, bringing the total number of Grylloblatta species to 15. Grylloblatta chintimini new species is described from Marys Peak in the Coast Range of Western Oregon, where it occurs on snowpack near the 1250 m summit. Grylloblatta newberryensis new species is described from Newberry Volcano in Central Oregon, where it is associated with snowfields overlying geologically-young lava flows...
2015: Zootaxa
Georgina G Gurney, Robert L Pressey, Natalie C Ban, Jorge G Álvarez-Romero, Stacy Jupiter, Vanessa M Adams
The efficacy of protected areas varies, partly because socioeconomic factors are not sufficiently considered in planning and management. Although integrating socioeconomic factors into systematic conservation planning is increasingly advocated, research is needed to progress from recognition of these factors to incorporating them effectively in spatial prioritization of protected areas. We evaluated 2 key aspects of incorporating socioeconomic factors into spatial prioritization: treatment of socioeconomic factors as costs or objectives and treatment of stakeholders as a single group or multiple groups...
October 2015: Conservation Biology: the Journal of the Society for Conservation Biology
Michael R Deyhle, Hung-Sheng Hsu, Timothy J Fairfield, Taryn L Cadez-Schmidt, Burke A Gurney, Christine M Mermier
Little research is available to guide training programs for rock climbers. To help meet this need, we sought to determine the relative importance of 4 muscle groups for rock climbing performance. Eleven male climbers were familiarized with an indoor climbing route before 5 separate days of testing. On testing days, subjects were randomly assigned to climb with no prefatiguing exercise (control climb) or after a prefatiguing exercise designed to specifically target the digit flexors (DF), shoulder adductors (SA), elbow flexors (EF), or lumbar flexors (LF)...
July 2015: Journal of Strength and Conditioning Research
Cheryl Cero, Vitaly V Vostrikov, Raffaello Verardi, Cinzia Severini, Tata Gopinath, Patrick D Braun, Maria F Sassano, Allison Gurney, Bryan L Roth, Lucy Vulchanova, Roberta Possenti, Gianluigi Veglia, Alessandro Bartolomucci
TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-associated disorders. TLQP-21 is found in the sympathetic nerve terminals in the adipose tissue and targets the G-protein-coupled receptor complement-3a receptor1 (C3aR1). The mechanisms of TLQP-21-induced receptor activation remain unexplored. Here, we report that TLQP-21 is intrinsically disordered and undergoes a disorder-to-order transition, adopting an α-helical conformation upon targeting cells expressing the C3aR1. We determined that the hot spots for TLQP-21 are located at the C terminus, with mutations in the last four amino acids progressively reducing the bioactivity and, a single site mutation (R21A) or C-terminal amidation abolishing its function completely...
December 2, 2014: Structure
Mark E Gurney, Emily C D'Amato, Alex B Burgin
Between 20% and 25% of patients diagnosed with Alzheimer's disease (AD) do not have amyloid burden as assessed by positron emission tomography imaging. Thus, there is a need for nonamyloid-directed therapies for AD, especially for those patients with non-amyloid AD. The family of phosphodiesterase-4 (PDE4) enzymes are underexploited therapeutic targets for central nervous system indications. While the PDE4A, B, and D subtypes are expressed in brain, the strict amino acid sequence conservation of the active site across the four subtypes of PDE4 has made it difficult to discover subtype inhibitors...
January 2015: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Rohit P Ojha, Tabatha N Offutt-Powell, James G Gurney
BACKGROUND: A large proportion of long-term survivors of childhood cancer have treatment-related adverse cardiac and pulmonary late-effects, with related mortality. Consequently, this population of approximately 379,000 individuals in the U.S. is at high risk of complications from influenza infections. PURPOSE: To estimate influenza vaccination coverage overall and among subgroups of adult survivors of pediatric cancer aged 18-64 years and to compare coverage with the general adult U...
June 2014: American Journal of Preventive Medicine
David Fox, Alex B Burgin, Mark E Gurney
Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor -Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-inflammatory drugs. This is due in part to the difficulty of developing selective PDE4B inhibitors as the amino acid sequence of the PDE4 active site is identical in all PDE4 subtypes (PDE4A-D). We show that highly selective PDE4B inhibitors can be designed by exploiting sequence differences outside the active site...
March 2014: Cellular Signalling
Diana M Pietri, Georgina G Gurney, Nancy Benitez-Vina, Audrey Kuklok, Sara M Maxwell, Libby Whiting, Michael A Vina, Lekelia D Jenkins
Seasoned conservation researchers often struggle to bridge the research-implementation gap and promote the translation of their work into meaningful conservation actions. Graduate students face the same problems and must contend with obstacles such as limited opportunities for relevant interdisciplinary training and a lack of institutional support for application of research results. However, students also have a crucial set of opportunities (e.g., access to academic resources outside their degree programs and opportunities to design research projects promoting collaboration with stakeholders) at their disposal to address these problems...
October 2013: Conservation Biology: the Journal of the Society for Conservation Biology
Kirsten K Ness, Kendra E Jones, Webb A Smith, Sheri L Spunt, Carmen L Wilson, Gregory T Armstrong, Deo Kumar Srivastava, Leslie L Robison, Melissa M Hudson, James G Gurney
OBJECTIVES: To ascertain prevalence of peripheral sensory and motor neuropathy, and to evaluate impairments in relation to function. DESIGN: St. Jude Lifetime Cohort Study, a clinical follow-up study designed to evaluate adverse late effects in adult survivors of childhood cancer. SETTING: A children's research hospital. PARTICIPANTS: Eligibility required treatment for an extracranial solid malignancy between 1962 and 2002, age ≥ 18 years, ≥ 10 years postdiagnosis, and no history of cranial radiation...
August 2013: Archives of Physical Medicine and Rehabilitation
Rohit P Ojha, Joseph E Tota, Tabatha N Offutt-Powell, James L Klosky, Ramkumar Ashokkumar, James G Gurney
PURPOSE: We assessed the accuracy of human papillomavirus (HPV) vaccination status based on adult proxy recall and household immunization records for adolescent females in the United States. METHODS: We used data from the 2010 National Immunization Survey-Teen for females aged 13 to 17 years. The accuracy of HPV vaccination status (≥1 dose) based on adult proxy recall (unweighted n = 6868) and household immunization records (unweighted n = 2216) was assessed by estimating the sensitivity, specificity, and corresponding 95% confidence limits (CL) of these measures with provider-reported HPV vaccination status as the reference standard...
May 2013: Annals of Epidemiology
Gianluca Baldassarre, Francesco Mannella, Vincenzo G Fiore, Peter Redgrave, Kevin Gurney, Marco Mirolli
Reinforcement (trial-and-error) learning in animals is driven by a multitude of processes. Most animals have evolved several sophisticated systems of 'extrinsic motivations' (EMs) that guide them to acquire behaviours allowing them to maintain their bodies, defend against threat, and reproduce. Animals have also evolved various systems of 'intrinsic motivations' (IMs) that allow them to acquire actions in the absence of extrinsic rewards. These actions are used later to pursue such rewards when they become available...
May 2013: Neural Networks: the Official Journal of the International Neural Network Society
Rohit P Ojha, S Cristina Oancea, Kirsten K Ness, Jennifer Q Lanctot, D Kumar Srivastava, Leslie L Robison, Melissa M Hudson, James G Gurney
BACKGROUND: To evaluate long-term health outcomes among childhood cancer survivors, St. Jude Children's Research Hospital (SJCRH) has established the St. Jude Lifetime Cohort Study (SJLIFE), comprised of adult survivors who undergo risk-directed clinical assessments. As in any human research study, SJLIFE participants are volunteers who may not represent the source population from which they were recruited. A lack of proportional representation could result in biased estimates of exposure-outcome associations...
May 2013: Pediatric Blood & Cancer
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