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https://www.readbyqxmd.com/read/29229323/mri-based-assessment-of-3d-intrafractional-motion-of-head-and-neck-cancer-for-radiation%C3%A2-therapy
#1
Oliver J Gurney-Champion, Dualta McQuaid, Alex Dunlop, Kee H Wong, Liam C Welsh, Angela M Riddell, Dow-Mu Koh, Uwe Oelfke, Martin O Leach, Christopher M Nutting, Shreerang A Bhide, Kevin J Harrington, Rafal Panek, Kate L Newbold
PURPOSE: To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement...
October 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29225493/a%C3%A2-post-gurney-quantum-mechanical-perspective-on-the-electrolysis-of-water-ion-neutralization-in-solution
#2
Enyi Guo, David R McKenzie
Electron fluxes crossing the interface between a metallic conductor and an aqueous environment are important in many fields; hydrogen production, environmental scanning tunnelling microscopy, scanning electrochemical microscopy being some of them. Gurney (Gurney 1931 Proc. R. Soc. Lond.134, 137 (doi:10.1098/rspa.1931.0187)) provided in 1931 a scheme for tunnelling during electrolysis and outlined conditions for it to occur. We measure the low-voltage current flows between gold electrodes in pure water and use the time-dependent behaviour at voltage switch-on and switch-off to evaluate the relative contribution to the steady current arising from tunnelling of electrons between the electrodes and ions in solution and from the neutralization of ions adsorbed onto the electrode surface...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29146617/cure-in-advanced-renal-cell-cancer-is-it-an-achievable-goal
#3
Dhanusha Sabanathan, John J Park, Manuel Marquez, Louise Francisco, Natalie Byrne, Howard Gurney
BACKGROUND: Immunotherapy has historically been of interest in the management of metastatic renal cell cancer (mRCC) because of its relative chemoresistance and the reproducible but low incidence of spontaneous remission in metastatic disease. Recently, targeted immunotherapies in the form of checkpoint inhibitors have shown durable responses in approximately 20%-30% of patients with solid tumors, with a much more acceptable side-effect profile. Anti-programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 antibodies rely on the presence of host T cells in the tumor microenvironment to be stimulated in order to activate an antitumor response...
November 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29126870/susceptibility-to-unconscious-influences-is-unaffected-by-a-challenging-inhibitory-task-or-mental-exhaustion
#4
Angela Gurney, Anna-Nepheli L Lagos, Abigail Manning, Ryan B Scott
Unconscious influences have been demonstrated in a variety of behavioural contexts, however, a key question remains - to what extent do such influences vary with our changing mental states? We examine whether a prior inhibitory challenge increases susceptibility to subliminal priming in a stem completion task employing neutral (Experiment 1) and reward salient terms (Experiment 2). Results show stem completions to be significantly influenced by unconscious priming, and the challenging inhibitory task (the Stroop) to be significantly more mentally exhausting than the control task...
November 7, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29116166/multiple-behavior-phenotypes-of-the-fragile-x-syndrome-mouse-model-respond-to-chronic-inhibition-of-phosphodiesterase-4d-pde4d
#5
Mark E Gurney, Patricia Cogram, Robert M Deacon, Christopher Rex, Michael Tranfaglia
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent finding in patients and in the mouse and fly FXS models. We therefore explored if BPN14770, a prototypic phosphodiesterase-4D negative allosteric modulator (PDE4D-NAM) in early human clinical trials, might provide therapeutic benefit in the mouse FXS model. Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperarousal, improved social interaction, and improved natural behaviors such as nesting and marble burying as well as dendritic spine morphology...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29101423/risk-of-lower-limb-amputation-in-a-national-prevalent-cohort-of-patients-with-diabetes
#6
Jason K Gurney, James Stanley, Steve York, Dieter Rosenbaum, Diana Sarfati
AIMS/HYPOTHESIS: Lower limb amputation is a serious complication of diabetes mellitus. Understanding how amputation risk differs by population subgroups is crucial in terms of directing preventive strategies. In this study, we describe those factors that impact amputation risk in the entire prevalent diabetic population of New Zealand. METHODS: A national prevalent cohort of 217,207 individuals with diabetes in 2010 were followed up until the end of 2013 for lower limb amputations, and 2014 for mortality...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29100565/nursing-code-of-ethics-provisions-and-interpretative-statements-for-emergency-nurses
#7
Diane Gurney, Gordon L Gillespie, Margaret Peggy McMahon, Monica Escalante Kolbuk
No abstract text is available yet for this article.
November 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29074662/complete-genome-sequences-of-cluster-a-mycobacteriophages-bobswaget-fred313-kady-lokk-myradee-stagni-and-stepmih
#8
Kristen A Butela, Susan M R Gurney, Heather L Hendrickson, Janine M LeBlanc-Straceski, Anastasia M Zimmerman, Stephanie B Conant, Nikki E Freed, Olin K Silander, Joshua J Thomson, Charlotte A Berkes, Cristina Bertolez, Courtney G Davies, Amber Elinsky, Alison J Hanlon, Juliette Nersesyan, Payal Patel, John Sherwood, Tiffany Tieu Ngo, Kathryn A Wisniewski, Kathrine Yacoo, Paul M Arendse, Nathan W Bowlen, Jasmina Cunmulaj, Julie L Downs, Charlee A Ferrenberg, Alexandra E Gassman, Cody E R Gilligan, Emily Gorkiewicz, Christopher Harness, Anthony Huffman, Christina Jones, Anna Julien, Alexis E Kupic, Sayonara F Latu, Thomas J Manning, Danielle Maxwell, Catherine E Meyer, Madeleine Reardon, Matthew Slaughter, Royce Swasey, Rebecca I Tennent, Victoria Torres, Tamia Waller, Rachel M Worcester, Brooke L Yost, Steven G Cresawn, Rebecca A Garlena, Deborah Jacobs-Sera, Welkin H Pope, Daniel A Russell, Graham F Hatfull, Jacob D Kagey
Seven mycobacteriophages from distinct geographical locations were isolated, using Mycobacterium smegmatis mc(2)155 as the host, and then purified and sequenced. All of the genomes are related to cluster A mycobacteriophages, BobSwaget and Lokk in subcluster A2; Fred313, KADY, Stagni, and StepMih in subcluster A3; and MyraDee in subcluster A18, the first phage to be assigned to that subcluster.
October 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29067429/association-of-prehospital-blood-product-transfusion-during-medical-evacuation-of-combat-casualties-in-afghanistan-with-acute-and-30-day-survival
#9
Stacy A Shackelford, Deborah J Del Junco, Nicole Powell-Dunford, Edward L Mazuchowski, Jeffrey T Howard, Russ S Kotwal, Jennifer Gurney, Frank K Butler, Kirby Gross, Zsolt T Stockinger
Importance: Prehospital blood product transfusion in trauma care remains controversial due to poor-quality evidence and cost. Sequential expansion of blood transfusion capability after 2012 to deployed military medical evacuation (MEDEVAC) units enabled a concurrent cohort study to focus on the timing as well as the location of the initial transfusion. Objective: To examine the association of prehospital transfusion and time to initial transfusion with injury survival...
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29039154/severe-headache-following-ozone-therapy-pneumocephalus
#10
Hüseyin Toman, Uğur Özdemir, Hasan Ali Kiraz, Nurettin Lüleci
Pneumocephalus is defined as air in the cranial cavity. Pneumocephalus can result from inadvertent dural puncture during lumbar epidural anesthesia or epidural steroid injection. Presently described is case of 41-year-old woman who had undergone lumbar disc hernia operation but due to ongoing complaints, was diagnosed as having failed back surgery syndrome. Percutaneous epidural neuroplasty was performed. In the operating room, under sterile conditions and under sedoanalgesia, Racz catheter was inserted in caudal area and guided to epidural area with scope...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29026011/contrasting-carbon-cycle-responses-of-the-tropical-continents-to-the-2015-2016-el-ni%C3%A3-o
#11
Junjie Liu, Kevin W Bowman, David S Schimel, Nicolas C Parazoo, Zhe Jiang, Meemong Lee, A Anthony Bloom, Debra Wunch, Christian Frankenberg, Ying Sun, Christopher W O'Dell, Kevin R Gurney, Dimitris Menemenlis, Michelle Gierach, David Crisp, Annmarie Eldering
The 2015-2016 El Niño led to historically high temperatures and low precipitation over the tropics, while the growth rate of atmospheric carbon dioxide (CO2) was the largest on record. Here we quantify the response of tropical net biosphere exchange, gross primary production, biomass burning, and respiration to these climate anomalies by assimilating column CO2, solar-induced chlorophyll fluorescence, and carbon monoxide observations from multiple satellites. Relative to the 2011 La Niña, the pantropical biosphere released 2...
October 13, 2017: Science
https://www.readbyqxmd.com/read/28982830/communicating-risk-in-active-surveillance-of-localised-prostate-cancer-a-protocol-for-a-qualitative-study
#12
Frances Rapport, Anne Hogden, Howard Gurney, David Gillatt, Mia Bierbaum, Patti Shih, Kate Churruca
INTRODUCTION: One in five men is likely to receive a diagnosis of prostate cancer (PCa) by the age of 85 years. Men diagnosed with low-risk PCa may be eligible for active surveillance (AS) to monitor their cancer to ensure that any changes are discovered and responded to in a timely way. Communication of risk in this context is more complicated than determining a numerical probability of risk, as patients wish to understand the implications of risk on their lives in concrete terms. Our study will examine how risk for PCa is perceived, experienced and communicated by patients using AS with their health professionals, and the implications for treatment and care...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28959385/dominant-immunosuppression-of-dendritic-cell-function-by-prostate-cancer-derived-exosomes
#13
Josephine Salimu, Jason Webber, Mark Gurney, Saly Al-Taei, Aled Clayton, Zsuzsanna Tabi
Exosomes are a distinct population of extracellular vesicles of endocytic origin with a protein repertoire similar to the parent cell. Although tumour-derived exosomes harbour immunosuppressive characteristics, they also carry tumour antigens and thus potentially contribute to immune activation. The aim of this study was to examine the impact of prostate cancer exosomes on tumour antigen cross-presentation. DU145 cells, transduced with shRNA to knockdown Rab27a (DU145(KD)) that inhibits exosome secretion, triggered significantly stronger tumour-antigen-specific T cell responses when loaded onto dendritic cells (DC) than control DU145 cells...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28950287/predicting-response-and-toxicity-to-immune-checkpoint-inhibitors-using-routinely-available-blood-and-clinical-markers
#14
REVIEW
Ashley M Hopkins, Andrew Rowland, Ganessan Kichenadasse, Michael D Wiese, Howard Gurney, Ross A McKinnon, Chris S Karapetis, Michael J Sorich
Immune checkpoint inhibitors (ICI) are an important development in the treatment of advanced cancer. A substantial proportion of patients treated with ICI do not respond, and additionally patients discontinue treatment due to adverse effects. While many novel biological markers related to the specific mechanisms of ICI actions have been investigated, there has also been considerable research to identify routinely available blood and clinical markers that may predict response to ICI therapy. If validated, these markers have the advantage of being easily integrated into clinical use for nominal expense...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28935833/how-to-use%C3%A2-the-direct-ophthalmoscope
#15
Sam P Gurney, Taiwo Makanjuola, Muhammad Kutubi, Manoj Parulekar, Joseph Abbott
Ophthalmoscopy and red reflex examination are core medical skills required to identify sight-threatening and life-threatening disease. We discuss the predictive utility and limitations of findings with an ophthalmoscope and tips as to how to optimise these. We outline important considerations in three clinical scenarios: an abnormal red reflex, an abnormal optic disc and retinal haemorrhages in the context of child protection concerns.
September 21, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28922080/factors-associated-with-residential-mobility-during-pregnancy
#16
Doris K Amoah, Vikki Nolan, George Relyea, James G Gurney, Xinhua Yu, Frances A Tylavsky, Fawaz Mzayek
Our objective was to determine the factors associated with residential moving during pregnancy, as it may increase stress during pregnancy and affect birth outcomes. Data were obtained from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Participants were recruited from December 2006 to June 2011 and included 1,448 pregnant women. The average gestational age at enrollment was 23 weeks. The primary outcome of residential mobility was defined as any change in address during pregnancy...
September 18, 2017: Women & Health
https://www.readbyqxmd.com/read/28916016/comparing-two-models-of-integrated-behavioral-health-programs-in-pediatric-primary-care
#17
REVIEW
Miguelina Germán, Michael L Rinke, Brittany A Gurney, Rachel S Gross, Diane E Bloomfield, Lauren A Haliczer, Silvie Colman, Andrew D Racine, Rahil D Briggs
This study examined how to design, staff, and evaluate the feasibility of 2 different models of integrated behavioral health programs in pediatric primary care across primary care sites in the Bronx, NY. Results suggest that the Behavioral Health Integration Program model of pediatric integrated care is feasible and that hiring behavioral health staff with specific training in pediatric, evidence-informed behavioral health treatments may be a critical variable in increasing outcomes such as referral rates, self-reported competency, and satisfaction...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28910226/the-bacterial-renaissance-a-supply-side-answer-to-the-icarus-paradox-of-antibiotic-usage-undermining-its-own-usefulness
#18
Gurney Fields Pearsall
No abstract text is available yet for this article.
January 2017: Journal of Legal Medicine
https://www.readbyqxmd.com/read/28874573/redefining-community-based-on-place-attachment-in-a-connected-world
#19
Georgina G Gurney, Jessica Blythe, Helen Adams, W Neil Adger, Matthew Curnock, Lucy Faulkner, Thomas James, Nadine A Marshall
The concept of community is often used in environmental policy to foster environmental stewardship and public participation, crucial prerequisites of effective management. However, prevailing conceptualizations of community based on residential location or resource use are limited with respect to their utility as surrogates for communities of shared environment-related interests, and because of the localist perspective they entail. Thus, addressing contemporary sustainability challenges, which tend to involve transnational social and environmental interactions, urgently requires additional approaches to conceptualizing community that are compatible with current globalization...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28870067/versatile-device-architectures-for-high-performing-light-soaking-free-inverted-polymer-solar-cells
#20
Yu Yan, Feilong Cai, Liyan Yang, Wei Li, Yanyan Gong, Jinlong Cai, Shuang Liu, Robert S Gurney, Dan Liu, Tao Wang
Metal oxide charge transport layers have been widely employed to prepare inverted polymer solar cells with high efficiency and long lifetime. However, the intrinsic defects in the metal oxide layers, especially those prepared from low-temperature routes, overshadow the high efficiency that can be achieved and also introduce "light-soaking" issues to these devices. In this work, we have employed polyethyleneimine (PEI) and poly(9,9-bis(6'-(N,N-diethylamino)propyl)-fluorene-alt-9,9-bis-(3-ethyl(oxetane-3-ethyloxy)-hexyl)-fluorene] (PFN-OX) to modify our low-temperature-processed TiO2 electron transport layer (ETL) and demonstrated that the light-soaking issue can be effectively eliminated by PEI modifications because of the formation of abundant dipole moments, whereas PFN-OX was ineffective as a result of deficient dipole moments at the interface...
September 27, 2017: ACS Applied Materials & Interfaces
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