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https://www.readbyqxmd.com/read/28649702/dose-considerations-for-anti-cancer-drugs-in-metastatic-prostate-cancer
#1
REVIEW
Megan Crumbaker, Howard Gurney
Despite a growing number of treatment options, metastatic castrate resistant prostate cancer remains almost universally fatal. Dose individualization ensures patients receive the maximal benefit from each line of treatment potentially leading to improved outcomes, a reduction in quality of life impairment and minimization of premature cessation for avoidable toxicity. Herein, we review drug-specific issues that may be associated with unexpected or unrecognized variations in drug systemic exposure despite the use of protocol doses...
June 26, 2017: Prostate
https://www.readbyqxmd.com/read/28629565/a-tri-exponential-model-for-intravoxel-incoherent-motion-analysis-of-the-human-kidney-in-silico-and-during-pharmacological-renal-perfusion-modulation
#2
René van der Bel, Oliver J Gurney-Champion, Martijn Froeling, Erik S G Stroes, Aart J Nederveen, C T Paul Krediet
In the kidneys, there is both blood flow through the capillaries and flow of pre-urine through the tubuli and collecting ducts. We hypothesized that diffusion-weighted (DW) MRI measures both blood and pre-urine flow when using a tri-exponential intravoxel incoherent motion (IVIM) model. Our aim was to systematically investigate and optimize tri-exponential IVIM-analysis for the kidney and test its sensitivity to renal perfusion changes in humans. The tri-exponential fit probes the diffusion coefficient (D), the intermediate (D*i) and fast (D*f) pseudo-diffusion coefficients, and their signal fractions, fD, fi and ff...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28616080/pedobarography-as-a-clinical-tool-in-the-management-of-diabetic-feet-in-new-zealand-a-feasibility-study
#3
Jason K Gurney, Uwe G Kersting, Dieter Rosenbaum, Ajith Dissanayake, Steve York, Roger Grech, Anthony Ng, Bobbie Milne, James Stanley, Diana Sarfati
BACKGROUND: The peripheral complications of diabetes mellitus remain a significant risk to lower-limb morbidity. In New Zealand, risk of diabetes, comorbidity and lower-limb amputation are highly-differential between demographic groups, particularly ethnicity. There is growing and convincing evidence that the use of pedobarography - or plantar pressure measurement - can usefully inform diabetic foot care, particularly with respect to the prevention of re-ulceration among high-risk patients...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28610221/first-record-of-spongillaflies-neuroptera-sisyridae-from-colombia
#4
Adrian Ardila-Camacho, Caleb C Martins
The family Sisyridae (spongillaflies) is a small group of neuropterans distributed in all Biogeographic realms (Cover & Resh 2008). As in Nevrorthidae, Sisyridae is distinguished among other Neuroptera families by their strictly aquatic larvae (Wichard et al. 2002). The phylogenetic relationships of Sisyridae have been controversial i.e. the family was recovered at different positions within the Neuropterida phylogeny as a basal group among members of Neuroptera or whitin the suborder Hemerobiiformia with a very variable placement (Randolf et al...
June 9, 2017: Zootaxa
https://www.readbyqxmd.com/read/28591075/comparison-of-the-vacuum-mattress-versus-the-spine-board-alone-for-immobilization-of-the-cervical-spine-injured-patient-a-biomechanical-cadaveric-study
#5
Mark L Prasarn, Per Kristian Hyldmo, Laura A Zdziarski, Evan Loewy, Dewayne Dubose, MaryBeth Horodyski, Glenn R Rechtine
STUDY DESIGN: Biomechanical cadaveric study. SUMMARY OF BACKGROUND DATA: Trauma patients in the United States are immobilized on a rigid spine board, whereas in many other places vacuum mattresses are used with the proposed advantages of improved comfort and better immobilization of the spine. OBJECTIVE: We sought to determine the amount of motion generated in an unstable cervical spine fracture with use of the vacuum mattress versus the spine board alone...
June 6, 2017: Spine
https://www.readbyqxmd.com/read/28549248/metastatic-chromophobe-renal-cell-carcinoma-treated-with-targeted-therapies-a-renal-cross-channel-group%C3%A2-study
#6
Emeline Colomba, Gwénaël Le Teuff, Tim Eisen, Grant D Stewart, Kate Fife, James Larkin, Andrea Biondo, Lisa Pickering, Anandagopal Srinivasan, Helen Boyle, Lisa Derosa, Cora N Sternberg, Federica Recine, Christy Ralph, Carolina Saldana, Philippe Barthélémy, Jean Christophe Bernhard, Howard Gurney, Gregory Verhoest, Elodie Vauleon, Pierre Bigot, Julien Berger, Christian Pfister, Gwenaelle Gravis, Jean-Michel Rodier, Stéphane Culine, Armelle Caty, Frederic Rolland, Franck Priou, Bernard Escudier, Laurence Albiges
BACKGROUND: Treatment of non-clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC. METHODS: We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era...
May 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28544085/e-tc-development-and-pilot-testing-of-a-web-based-intervention-to-reduce-anxiety-and-depression-in-survivors-of-testicular-cancer
#7
L E Heiniger, A B Smith, I Olver, P Grimison, B Klein, A Wootten, J-A M Abbott, M A Price, M McJannett, B Tran, M R Stockler, H Gurney, P N Butow
e-TC is an online intervention designed to address common psychosocial concerns of testicular cancer survivors. It aims to reduce anxiety, depression and fear of cancer recurrence by providing evidence-based information and psychological intervention. This paper details the development and pilot testing of e-TC. During pilot testing, 25 men (with varying psychological profiles) who had completed treatment for testicular cancer, 6 months to 5 years ago (which had not recurred), used e-TC over a 10-week period and provided quantitative and qualitative feedback on the feasibility and acceptability of the programme...
May 22, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28542295/therapeutic-benefits-of-phosphodiesterase-4b-inhibition-after-traumatic-brain-injury
#8
Nicole M Wilson, Mark E Gurney, W Dalton Dietrich, Coleen M Atkins
Traumatic brain injury (TBI) initiates a deleterious inflammatory response that exacerbates pathology and worsens outcome. This inflammatory response is partially mediated by a reduction in cAMP and a concomitant upregulation of cAMP-hydrolyzing phosphodiesterases (PDEs) acutely after TBI. The PDE4B subfamily, specifically PDE4B2, has been found to regulate cAMP in inflammatory cells, such as neutrophils, macrophages and microglia. To determine if PDE4B regulates inflammation and subsequent pathology after TBI, adult male Sprague Dawley rats received sham surgery or moderate parasagittal fluid-percussion brain injury (2 ± 0...
2017: PloS One
https://www.readbyqxmd.com/read/28514618/aerobic-or-resistance-exercise-or-both-in-dieting-obese-older-adults
#9
RANDOMIZED CONTROLLED TRIAL
Dennis T Villareal, Lina Aguirre, A Burke Gurney, Debra L Waters, David R Sinacore, Elizabeth Colombo, Reina Armamento-Villareal, Clifford Qualls
BACKGROUND: Obesity causes frailty in older adults; however, weight loss might accelerate age-related loss of muscle and bone mass and resultant sarcopenia and osteopenia. METHODS: In this clinical trial involving 160 obese older adults, we evaluated the effectiveness of several exercise modes in reversing frailty and preventing reduction in muscle and bone mass induced by weight loss. Participants were randomly assigned to a weight-management program plus one of three exercise programs - aerobic training, resistance training, or combined aerobic and resistance training - or to a control group (no weight-management or exercise program)...
May 18, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28513321/active-travel-to-and-from-school-among-school-age-children-during-1997-2011-and-associated-factors-in-china
#10
Yong Yang, Xue Hong, James G Gurney, Youfa Wang
BACKGROUND: Active travel to school (ATS) is positively associated with various health indicators. The rapid social, economic and environmental changes in China provide a unique setting to study changes and predictors of ATS over time. METHODS: Using logistic regression modeling, we analyzed data from the China Health and Nutrition Survey during 1997-2011 (N=9487, ages 6-17 years) to estimate the change over time in ATS and to identify associated factors. RESULTS: The prevalence of reported ATS among children dropped from 95...
May 17, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28488360/cabazitaxel-in-patients-with-metastatic-castration-resistant-prostate-cancer-safety-and-quality-of-life-data-from-the-australian-early-access-program
#11
Phillip Parente, Siobhan Ng, Francis Parnis, Alex Guminski, Howard Gurney
AIM: Cabazitaxel is a next generation taxane that has been shown to improve overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed during or after docetaxel-based therapy. A worldwide early access program (EAP) study was established to provide access to cabazitaxel ahead of commercial availability and to evaluate its safety and tolerability. The Australian EAP included patient-reported outcomes to evaluate the impact of cabazitaxel on quality of life (QoL)...
May 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28475622/target-distractor-synchrony-affects-performance-in-a-novel-motor-task-for-studying-action-selection
#12
Sebastian James, Olivia A Bell, Muhammed A M Nazli, Rachel E Pearce, Jonathan Spencer, Katie Tyrrell, Phillip J Paine, Timothy J Heaton, Sean Anderson, Mauro Da Lio, Kevin Gurney
The study of action selection in humans can present challenges of task design since our actions are usually defined by many degrees of freedom and therefore occupy a large action-space. While saccadic eye-movement offers a more constrained paradigm for investigating action selection, the study of reach-and-grasp in upper limbs has often been defined by more complex scenarios, not easily interpretable in terms of such selection. Here we present a novel motor behaviour task which addresses this by limiting the action space to a single degree of freedom in which subjects have to track (using a stylus) a vertical coloured target line displayed on a tablet computer, whilst ignoring a similarly oriented distractor line in a different colour...
2017: PloS One
https://www.readbyqxmd.com/read/28429452/real-world-experience-of-the-feasibility-and-tolerability-of-the-2-1-dosing-schedule-with-sunitinib-in-the-treatment-of-patients-with-advanced-renal-cell-carcinoma-in-australia
#13
Megan Crumbaker, Alexander Guminski, Howard Gurney, Dhanusha Sabanathan, Shirley Wong, Nick Pavlakis
AIM: Sunitinib is a first-line treatment option for metastatic renal cell carcinoma (mRCC) funded by the Australian Pharmaceutical Benefits Scheme. Toxicities are common with the standard schedule leading to alternative dosing schedules to be suggested. We reviewed Australian treatment practices to evaluate the safety and outcomes of patients on a 2 weeks on, 1 week off treatment schedule (2/1). METHODS: We performed a retrospective review of 63 patients with mRCC treated with first-line sunitinib on a 2/1 schedule at four Australian centers...
April 21, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28426558/combat-surgical-workload-in-operation-iraqi-freedom-and-operation-enduring-freedom-the-definitive-analysis
#14
Caryn A Turner, Zsolt T Stockinger, Jennifer M Gurney
BACKGROUND: Relatively few publications exist on surgical workload in the deployed military setting. This study analyzes US military combat surgical workload in Iraq and Afghanistan to gain a more thorough understanding of surgical training gaps and personnel requirements. METHODS: A retrospective analysis of the Department of Defense Trauma Registry was performed for all Role 2 (R2) and Role 3 (R3) military treatment facilities from January 2001 to May 2016. International Classification of Diseases, Ninth Revision, Clinical Modification procedure codes were grouped into 18 categories based on functional surgical skill sets...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28419466/the-2016-revised-world-health-organization-definition-of-myelodysplastic-syndrome-with-isolated-del-5q-prognostic-implications-of-single-versus-double-cytogenetic-abnormalities
#15
Mark Gurney, Mrinal M Patnaik, Curtis A Hanson, Mark R Litzow, Aref Al-Kali, Rhett P Ketterling, Ayalew Tefferi, Naseema Gangat
The definition of the myelodysplastic syndrome (MDS) subtype 'MDS with isolated del(5q)' was expanded to include cases with one additional non-chromosome 7 based cytogenetic abnormality in the 2016 revised World Health Organization classification. This study applied the revised definition to a large primary MDS cohort, and evaluated the prognostic impact of the additional cytogenetic abnormality. Seventy-two of 1067 patients (7%) met the 'MDS with isolated del(5q)' criteria, 11 (1%) of whom had an additional cytogenetic abnormality...
April 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28410865/treatment-beyond-progression-in-patients-with-advanced-renal-cell-carcinoma-treated-with-nivolumab-in-checkmate-025
#16
Bernard Escudier, Robert J Motzer, Padmanee Sharma, John Wagstaff, Elizabeth R Plimack, Hans J Hammers, Frede Donskov, Howard Gurney, Jeffrey A Sosman, Pawel G Zalewski, Ulrika Harmenberg, David F McDermott, Toni K Choueiri, Martin Richardet, Yoshihiko Tomita, Alain Ravaud, Justin Doan, Huanyu Zhao, Helene Hardy, Saby George
BACKGROUND: Response patterns to nivolumab differ from those seen with other approved targeted therapies. OBJECTIVE: To investigate the efficacy of nivolumab in previously treated patients with advanced renal cell carcinoma who were treated beyond (Response Evaluation Criteria In Solid Tumors) RECIST progression. DESIGN, SETTING, AND PARTICIPANTS: This was a subgroup analysis of patients treated with nivolumab in the phase 3 CheckMate 025 study...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28375667/addition-of-mri-for-ct-based-pancreatic-tumor-delineation-a-feasibility-study
#17
Oliver J Gurney-Champion, Eva Versteijne, Astrid van der Horst, Eelco Lens, Heidi Rütten, Hanne D Heerkens, Gabriel M R M Paardekooper, Maaike Berbee, Coen R N Rasch, Jaap Stoker, Marc R W Engelbrecht, Marcel van Herk, Aart J Nederveen, Remy Klaassen, Hanneke W M van Laarhoven, Geertjan van Tienhoven, Arjan Bel
PURPOSE: To assess the effect of additional magnetic resonance imaging (MRI) alongside the planning computed tomography (CT) scan on target volume delineation in pancreatic cancer patients. MATERIAL AND METHODS: Eight observers (radiation oncologists) from six institutions delineated the gross tumor volume (GTV) on 3DCT, and internal GTV (iGTV) on 4DCT of four pancreatic cancer patients, while MRI was available in a second window (CT + MRI). Variations in volume, generalized conformity index (CIgen), and overall observer variation, expressed as standard deviation (SD) of the distances between delineated surfaces, were analyzed...
April 4, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28336036/physical-function-and-physical-activity-in-obese-adults-after-total-knee-arthroplasty
#18
REVIEW
Webb A Smith, Audrey Zucker-Levin, William M Mihalko, Michael Williams, Mark Loftin, James G Gurney
Obese patients are more likely to have osteoarthritis and total knee arthroplasty (TKA). This investigation sought to evaluate physical function, activity level, and quality of life (QOL). Obese participants near 1-year postsurgical follow-up appointment were recruited. Evaluation included QOL and activity questionnaire, medical histories, anthropometrics, strength, and aerobic capacity. Sixty participants completed assessments. Obese TKA patients have physical performance limitations and low physical activity levels 1 year after surgery and completion of postoperative rehabilitation...
April 2017: Orthopedic Clinics of North America
https://www.readbyqxmd.com/read/28335780/considerable-interobserver-variation-in-delineation-of-pancreatic-cancer-on-3dct-and-4dct-a-multi-institutional-study
#19
RANDOMIZED CONTROLLED TRIAL
Eva Versteijne, Oliver J Gurney-Champion, Astrid van der Horst, Eelco Lens, M Willemijn Kolff, Jeroen Buijsen, Gati Ebrahimi, Karen J Neelis, Coen R N Rasch, Jaap Stoker, Marcel van Herk, Arjan Bel, Geertjan van Tienhoven
BACKGROUND: The delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT. METHODS: Eight observers (radiation oncologists) from six institutions delineated pancreatic tumors of four patients with (borderline) resectable pancreatic cancer. The study consisted of two stages. In the 3DCT-stage, the gross tumor volume (GTV) was delineated on a contrast-enhanced scan...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28334424/frequency-and-function-in-the-basal-ganglia-the-origins-of-beta-and-gamma-band-activity
#20
Alexander Blenkinsop, Sean Anderson, Kevin Gurney
KEY POINTS: Neuronal oscillations in the basal ganglia have been observed to correlate with behaviours, although the causal mechanisms and functional significance of these oscillations remain unknown. We present a novel computational model of the healthy basal ganglia, constrained by single unit recordings from non-human primates. When the model is run using inputs that might be expected during performance of a motor task, the network shows emergent phenomena: it functions as a selection mechanism and shows spectral properties that match those seen in vivo...
March 23, 2017: Journal of Physiology
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