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https://www.readbyqxmd.com/read/29444652/physical-activity-and-risk-of-testicular-cancer-a-systematic-review
#1
Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn, Jason Gurney
BACKGROUND: Physical activity has been implicated as a risk factor in the development of testicular cancer (TC), but the relationship remains controversial. This systematic review pooled available evidence regarding this association. METHODS: Using Boolean search terms and following PRISMA guidelines, we examined the risk of TC across three categories of exposure: intensity (i.e. comparison of risk between those previously exposed to high, moderate and low levels of physical activity); dose-response (i...
February 14, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29443866/factors-associated-with-trauma-patients-length-of-stay-at-role-2-facilities-in-afghanistan-october-2009-to-september-2014
#2
Amanda Staudt, Jennifer Gurney, Krystal Valdez-Delgado, Mithun Suresh, Jennifer Trevino, Tuan Le, Jason Seery, Stacy Shackelford, Shawn Nessen, Elizabeth Mann-Salinas
BACKGROUND: Understanding patients' length of stay at far-forward Role 2 surgical units may help to determine support needs, stabilization requirements, pre-deployment training, and necessity of increased care capability prior to or during transport to a higher level of care. The objectives of this study were to 1) evaluate the amount of time patients spent at Role 2 and 2) determine factors associated with trauma patients' length of stay at Role 2. METHODS: We conducted a secondary data analysis of the Joint Trauma System Role 2 Database...
February 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29437101/complete-genome-sequence-of-cluster-j-mycobacteriophage-superphikiman
#3
Pratik Pradhan, Sprikena Nako, Trinh Tran, Lavanya S Aluri, Dharman Anandarajan, Niteesha Betini, Shivangi D Bhatt, Swetha Chengalvala, Nicole E Cox, Bela P Delvadia, Aishwary S Desai, Andrew M Devaney, Brenna K Doyle, Arden O Edgerton, Matthew C Erlich, Kevin C Fitzpatrick, Esha A Gajjar, Anjali Ganguly, Ramnik S Gill, Pauline M Good, Nishtha Gupta, Leila M Haddad, Esther J Han, Shelby Jain, Andrew Jiang, Andrew D Jurgielewicz, Devneet K Kainth, Jawhara M Karam, Mallika Kodavatiganti, Sinja J Kriete, Catherine E MacDonald, Josh P Maret, Ashley E Mathew, Maanasa Natrajan, Nusrat M Nishu, Nirali Patel, Pooja D Patel, Shivani Patel, Kaustav Patra, Karima K Rai, Arghyadeep Sarkar, Priyanka Shah, Ravi K Tata, Andrew H Tawfik, Bhavya T Thuremella, Justina Toma, Shika Veera, Vamsee K Vemulapalli, Trevor V Vidas, Katy S Vieira, Gayathri Vijayakumar, Tru A Walor, Clara R White, Brianna M Wong, Shu L Zhao, David W Bollivar, Matthew T McDonald, Ritu R Dalia, Kevin P W Smith, Joy L Little, Susan M R Gurney
Mycobacteriophage Superphikiman is a cluster J bacteriophage which was isolated from soil collected in Philadelphia, PA. Superphikiman has a 109,799-bp genome with 239 predicted genes, including 2 tRNA genes.
February 1, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29422665/application-of-bayes-to-the-prediction-of-referral-decisions-made-by-specialist-optometrists-in-relation-to-chronic-open-angle-glaucoma
#4
J C Gurney, E Ansari, D Harle, N O'Kane, R V Sagar, M C M Dunne
PURPOSE: To determine the accuracy of a Bayesian learning scheme (Bayes') applied to the prediction of clinical decisions made by specialist optometrists in relation to the referral refinement of chronic open angle glaucoma. METHODS: This cross-sectional observational study involved collection of data from the worst affected or right eyes of a consecutive sample of cases (n = 1,006) referred into the West Kent Clinical Commissioning Group Community Ophthalmology Team (COT) by high street optometrists...
February 9, 2018: Eye
https://www.readbyqxmd.com/read/29381142/exploring-the-validity-and-limitations-of-the-mott-gurney-law-for-charge-carrier-mobility-determination-of-semiconducting-thin-films
#5
Jason Alexander Rohr, Davide Moia, Saif A Haque, Thomas Kirchartz, Jenny Nelson
Using drift-diffusion simulations, we investigate the voltage dependence of the dark current in single carrier devices, typically used to determine charge-carrier mobilities. For both low and high voltages, the current increases linearly with the applied voltage. Whereas the linear current at low voltages is mainly due to space charge in the middle of the device, the linear current at high voltage is caused by charge-carrier saturation due to a high degree of injection. As a consequence, the current density at these voltages does not follow the classical square law derived by Mott and Gurney, and we show that for trap-free devices, only for intermediate voltages, a space-charge-limited drift current can be observed with a slope that approaches two...
January 30, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29370066/abdominal-trauma-surgery-during-recent-u-s-combat-operations-from-2002-2016
#6
Zsolt T Stockinger, Caryn A Turner, Jennifer M Gurney
BACKGROUND: Abdominal surgery constitutes approximately 13% of surgical procedures performed for combat injuries. This study examines the frequencies and type of abdominal surgical procedures performed during recent U.S. Military operations. METHODS: A retrospective analysis of the Department of Defense Trauma Registry (DoDTR) was performed for all Role 2 (R2) and Role 3 (R3) medical treatment facilities (MTFs), from January 2002 to May 2016. The 273 ICD-9-CM procedure codes that were identified as abdominal surgical procedures were stratified into 24 groups based on anatomic and functional classifications and then grouped by whether or not they were laparoscopic...
January 24, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29369076/analysis-of-pediatric-trauma-in-combat-zone-to-inform-high-fidelity-simulation-predeployment-training
#7
Patrick T Reeves, Marc M Auerbach, Tuan D Le, Nicole W Caldwell, Mary J Edwards, Elizabeth A Mann-Salinas, Jennifer M Gurney, Zsolt T Stockinger, Matthew A Borgman
OBJECTIVES: The military uses "just-in-time" training to refresh deploying medical personnel on skills necessary for medical and surgical care in the theater of operations. The burden of pediatric care at Role 2 facilities has yet to be characterized; pediatric predeployment training has been extremely limited and primarily informed by anecdotal experience. The goal of this analysis was to describe pediatric care at Role 2 facilities to enable data-driven development of high-fidelity simulation training and core knowledge concepts specific to the combat zone...
January 23, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29367611/genome-wide-association-study-of-paclitaxel-and-carboplatin-disposition-in-women-with-epithelial-ovarian-cancer
#8
Bo Gao, Yi Lu, Annemieke J M Nieuweboer, Hongmei Xu, Jonathan Beesley, Ingrid Boere, Anne-Joy M de Graan, Peter de Bruijn, Howard Gurney, Catherine J Kennedy, Yoke-Eng Chiew, Sharon E Johnatty, Philip Beale, Michelle Harrison, Craig Luccarini, Don Conroy, Ron H J Mathijssen, Paul R Harnett, Rosemary L Balleine, Georgia Chenevix-Trench, Stuart Macgregor, Anna de Fazio
Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition, limiting patient recruitment. We found that carboplatin and paclitaxel disposition are stable phenotypes in ovarian cancer patients and tested a genome-wide association study (GWAS) design to identify SNPs associated with chemotherapy disposition...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367186/the-use-of-facebook-advertising-to-recruit-healthy-elderly-people-for-a-clinical-trial-baseline-metrics
#9
Julie M Cowie, Mark E Gurney
BACKGROUND: This report provides data on the use of social media advertising as a clinical trial recruitment strategy targeting healthy volunteers aged 60 years and older. The social media advertising campaign focused on enrollment for a Phase 1 clinical trial. Traditional means of recruiting-billboards, newspaper advertising, word of mouth, personal referrals, and direct mail-were not producing enough qualified participants. OBJECTIVE: To demonstrate the effectiveness of using targeted advertising on the social networking site Facebook to recruit people aged 60 years and older for volunteer clinical trial participation...
January 24, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29357689/a-qualitative-exploration-of-the-experiences-of-adoptive-parents-attending-nurturing-attachments-a-dyadic-developmental-psychotherapy-informed-group
#10
Olivia Hewitt, Ben Gurney-Smith, Kim Golding
Children who are adopted have frequently experienced a range of aversive experience which impact on their ability to form secure attachments. Dyadic Developmental Psychotherapy (DDP) is an intervention designed to develop and promote secure attachments with children who have experienced developmental trauma. Eight adoptive parents participated in semi-structured interviews regarding their experiences of attending the 'Nurturing Attachment' group informed by DDP. The transcripts of their interviews were explored using Interpretative Phenomenological Analysis...
January 1, 2018: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/29341131/a-retrospective-study-of-feline-trauma-patients-admitted-to-a-referral-centre
#11
T Hernon, M Gurney, S Gibson
OBJECTIVE: To identify prognostic information and provide recommendations for management of feline trauma patients. METHODS: Retrospective analysis of case records for 185 cats presented as emergency trauma cases to a referral hospital between February 2009 and December 2013. Each case was assigned a severity score from 1 (very minor injuries) to 6 (moribund, dying). The data were analysed using Mann-Whitney U and Spearman's rank correlation tests. Logistic regression was used to calculate odds ratios...
January 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29334570/the-effect-of-prehospital-transport-time-injury-severity-and-blood-transfusion-on-survival-of-us-military-casualties-in-iraq
#12
Russ S Kotwal, Laura L F Scott, Jud C Janak, Bruce W Tarpey, Jeffrey T Howard, Edward L Mazuchowski, Frank K Butler, Stacy A Shackelford, Jennifer M Gurney, Zsolt T Stockinger
BACKGROUND: Reducing time from injury to care can optimize trauma patient outcomes. A previous study of prehospital transport of US military casualties during the Afghanistan conflict demonstrated the importance of time and treatment capability for combat casualty survival. METHODS: A retrospective descriptive analysis was conducted to analyze battlefield data collected on US military combat casualties during the Iraq conflict from March 19, 2003 to August 31, 2010...
January 12, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29306512/erratum-to-checkmate-025-randomized-phase-3-study-outcomes-by-key-baseline-factors-and-prior-therapy-for-nivolumab-versus-everolimus-in-advanced-renal-cell-carcinoma-eur-urol-2017-72-962-71
#13
Bernard Escudier, Padmanee Sharma, David F McDermott, Saby George, Hans J Hammers, Sandhya Srinivas, Scott S Tykodi, Jeffrey A Sosman, Giuseppe Procopio, Elizabeth R Plimack, Daniel Castellano, Howard Gurney, Frede Donskov, Katriina Peltola, John Wagstaff, Thomas C Gauler, Takeshi Ueda, Huanyu Zhao, Ian M Waxman, Robert J Motzer
No abstract text is available yet for this article.
January 3, 2018: European Urology
https://www.readbyqxmd.com/read/29280466/image-distortions-on-a-plastic-interstitial-computed-tomography-magnetic-resonance-brachytherapy-applicator-at-3%C3%A2-tesla-magnetic-resonance-imaging-and-their-dosimetric-impact
#14
Laura E van Heerden, Zdenko van Kesteren, Oliver J Gurney-Champion, Antonetta C Houweling, Kees Koedooder, Coen R N Rasch, Bradley R Pieters, Arjan Bel
PURPOSE: To quantify magnetic resonance imaging (MRI) distortions on a plastic intracavitary/interstitial applicator with plastic needles at a field strength of 3 T and to determine the dosimetric impact, using patient data. METHODS AND MATERIALS: For 11 cervical cancer patients, our clinical MRI protocol was extended with 3 scans. From the first scan, a multi-echo acquisition, a map of the magnetic field (B0) was calculated and used to quantify the field inhomogeneity...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29274104/designing-connected-marine-reserves-in-the-face-of-global-warming
#15
Jorge G Álvarez-Romero, Adrián Munguía-Vega, Maria Beger, Maria Del Mar Mancha-Cisneros, Alvin N Suárez-Castillo, Georgina G Gurney, Robert L Pressey, Leah R Gerber, Hem Nalini Morzaria-Luna, Héctor Reyes-Bonilla, Vanessa M Adams, Melanie Kolb, Erin M Graham, Jeremy VanDerWal, Alejandro Castillo-López, Gustavo Hinojosa-Arango, David Petatán-Ramírez, Marcia Moreno-Baez, Carlos R Godínez-Reyes, Jorge Torre
Marine reserves are widely used to protect species important for conservation and fisheries and to help maintain ecological processes that sustain their populations, including recruitment and dispersal. Achieving these goals requires well-connected networks of marine reserves that maximize larval connectivity, thus allowing exchanges between populations and recolonization after local disturbances. However, global warming can disrupt connectivity by shortening potential dispersal pathways through changes in larval physiology...
December 22, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29229323/mri-based-assessment-of-3d-intrafractional-motion-of-head-and-neck-cancer-for-radiation%C3%A2-therapy
#16
Oliver J Gurney-Champion, Dualta McQuaid, Alex Dunlop, Kee H Wong, Liam C Welsh, Angela M Riddell, Dow-Mu Koh, Uwe Oelfke, Martin O Leach, Christopher M Nutting, Shreerang A Bhide, Kevin J Harrington, Rafal Panek, Kate L Newbold
PURPOSE: To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC in the treatment position were analyzed. Dynamic contrast-enhanced magnetic resonance imaging consisted of 3D images acquired every 2.9 seconds for 4 minutes 50 seconds. Intrafractional tumor motion was studied in the 3 minutes 43 seconds of images obtained after initial contrast enhancement...
October 16, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29225493/a%C3%A2-post-gurney-quantum-mechanical-perspective-on-the-electrolysis-of-water-ion-neutralization-in-solution
#17
Enyi Guo, David R McKenzie
Electron fluxes crossing the interface between a metallic conductor and an aqueous environment are important in many fields; hydrogen production, environmental scanning tunnelling microscopy, scanning electrochemical microscopy being some of them. Gurney (Gurney 1931 Proc. R. Soc. Lond.134, 137 (doi:10.1098/rspa.1931.0187)) provided in 1931 a scheme for tunnelling during electrolysis and outlined conditions for it to occur. We measure the low-voltage current flows between gold electrodes in pure water and use the time-dependent behaviour at voltage switch-on and switch-off to evaluate the relative contribution to the steady current arising from tunnelling of electrons between the electrodes and ions in solution and from the neutralization of ions adsorbed onto the electrode surface...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29146617/cure-in-advanced-renal-cell-cancer-is-it-an-achievable-goal
#18
Dhanusha Sabanathan, John J Park, Manuel Marquez, Louise Francisco, Natalie Byrne, Howard Gurney
BACKGROUND: Immunotherapy has historically been of interest in the management of metastatic renal cell cancer (mRCC) because of its relative chemoresistance and the reproducible but low incidence of spontaneous remission in metastatic disease. Recently, targeted immunotherapies in the form of checkpoint inhibitors have shown durable responses in approximately 20%-30% of patients with solid tumors, with a much more acceptable side-effect profile. Anti-programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 antibodies rely on the presence of host T cells in the tumor microenvironment to be stimulated in order to activate an antitumor response...
November 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29126870/susceptibility-to-unconscious-influences-is-unaffected-by-a-challenging-inhibitory-task-or-mental-exhaustion
#19
Angela Gurney, Anna-Nepheli L Lagos, Abigail Manning, Ryan B Scott
Unconscious influences have been demonstrated in a variety of behavioural contexts, however, a key question remains - to what extent do such influences vary with our changing mental states? We examine whether a prior inhibitory challenge increases susceptibility to subliminal priming in a stem completion task employing neutral (Experiment 1) and reward salient terms (Experiment 2). Results show stem completions to be significantly influenced by unconscious priming, and the challenging inhibitory task (the Stroop) to be significantly more mentally exhausting than the control task...
November 7, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29116166/multiple-behavior-phenotypes-of-the-fragile-x-syndrome-mouse-model-respond-to-chronic-inhibition-of-phosphodiesterase-4d-pde4d
#20
Mark E Gurney, Patricia Cogram, Robert M Deacon, Christopher Rex, Michael Tranfaglia
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent finding in patients and in the mouse and fly FXS models. We therefore explored if BPN14770, a prototypic phosphodiesterase-4D negative allosteric modulator (PDE4D-NAM) in early human clinical trials, might provide therapeutic benefit in the mouse FXS model. Daily treatment of adult male fmr1 C57Bl6 knock-out mice with BPN14770 for 14 days reduced hyperarousal, improved social interaction, and improved natural behaviors such as nesting and marble burying as well as dendritic spine morphology...
November 7, 2017: Scientific Reports
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