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https://www.readbyqxmd.com/read/29039154/severe-headache-following-ozone-therapy-pneumocephalus
#1
Hüseyin Toman, Uğur Özdemir, Hasan Ali Kiraz, Nurettin Lüleci
Pneumocephalus is defined as air in the cranial cavity. Pneumocephalus can result from inadvertent dural puncture during lumbar epidural anesthesia or epidural steroid injection. Presently described is case of 41-year-old woman who had undergone lumbar disc hernia operation but due to ongoing complaints, was diagnosed as having failed back surgery syndrome. Percutaneous epidural neuroplasty was performed. In the operating room, under sterile conditions and under sedoanalgesia, Racz catheter was inserted in caudal area and guided to epidural area with scope...
July 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/29026011/contrasting-carbon-cycle-responses-of-the-tropical-continents-to-the-2015-2016-el-ni%C3%A3-o
#2
Junjie Liu, Kevin W Bowman, David S Schimel, Nicolas C Parazoo, Zhe Jiang, Meemong Lee, A Anthony Bloom, Debra Wunch, Christian Frankenberg, Ying Sun, Christopher W O'Dell, Kevin R Gurney, Dimitris Menemenlis, Michelle Gierach, David Crisp, Annmarie Eldering
The 2015-2016 El Niño led to historically high temperatures and low precipitation over the tropics, while the growth rate of atmospheric carbon dioxide (CO2) was the largest on record. Here we quantify the response of tropical net biosphere exchange, gross primary production, biomass burning, and respiration to these climate anomalies by assimilating column CO2, solar-induced chlorophyll fluorescence, and carbon monoxide observations from multiple satellites. Relative to the 2011 La Niña, the pantropical biosphere released 2...
October 13, 2017: Science
https://www.readbyqxmd.com/read/28982830/communicating-risk-in-active-surveillance-of-localised-prostate-cancer-a-protocol-for-a-qualitative-study
#3
Frances Rapport, Anne Hogden, Howard Gurney, David Gillatt, Mia Bierbaum, Patti Shih, Kate Churruca
INTRODUCTION: One in five men is likely to receive a diagnosis of prostate cancer (PCa) by the age of 85 years. Men diagnosed with low-risk PCa may be eligible for active surveillance (AS) to monitor their cancer to ensure that any changes are discovered and responded to in a timely way. Communication of risk in this context is more complicated than determining a numerical probability of risk, as patients wish to understand the implications of risk on their lives in concrete terms. Our study will examine how risk for PCa is perceived, experienced and communicated by patients using AS with their health professionals, and the implications for treatment and care...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28959385/dominant-immunosuppression-of-dendritic-cell-function-by-prostate-cancer-derived-exosomes
#4
Josephine Salimu, Jason Webber, Mark Gurney, Saly Al-Taei, Aled Clayton, Zsuzsanna Tabi
Exosomes are a distinct population of extracellular vesicles of endocytic origin with a protein repertoire similar to the parent cell. Although tumour-derived exosomes harbour immunosuppressive characteristics, they also carry tumour antigens and thus potentially contribute to immune activation. The aim of this study was to examine the impact of prostate cancer exosomes on tumour antigen cross-presentation. DU145 cells, transduced with shRNA to knockdown Rab27a (DU145(KD)) that inhibits exosome secretion, triggered significantly stronger tumour-antigen-specific T cell responses when loaded onto dendritic cells (DC) than control DU145 cells...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28950287/predicting-response-and-toxicity-to-immune-checkpoint-inhibitors-using-routinely-available-blood-and-clinical-markers
#5
REVIEW
Ashley M Hopkins, Andrew Rowland, Ganessan Kichenadasse, Michael D Wiese, Howard Gurney, Ross A McKinnon, Chris S Karapetis, Michael J Sorich
Immune checkpoint inhibitors (ICI) are an important development in the treatment of advanced cancer. A substantial proportion of patients treated with ICI do not respond, and additionally patients discontinue treatment due to adverse effects. While many novel biological markers related to the specific mechanisms of ICI actions have been investigated, there has also been considerable research to identify routinely available blood and clinical markers that may predict response to ICI therapy. If validated, these markers have the advantage of being easily integrated into clinical use for nominal expense...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28935833/how-to-use%C3%A2-the-direct-ophthalmoscope
#6
Sam P Gurney, Taiwo Makanjuola, Muhammad Kutubi, Manoj Parulekar, Joseph Abbott
Ophthalmoscopy and red reflex examination are core medical skills required to identify sight-threatening and life-threatening disease. We discuss the predictive utility and limitations of findings with an ophthalmoscope and tips as to how to optimise these. We outline important considerations in three clinical scenarios: an abnormal red reflex, an abnormal optic disc and retinal haemorrhages in the context of child protection concerns.
September 21, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28922080/factors-associated-with-residential-mobility-during-pregnancy
#7
Doris K Amoah, Vikki Nolan, George Relyea, James G Gurney, Xinhua Yu, Frances A Tylavsky, Fawaz Mzayek
Our objective was to determine the factors associated with residential moving during pregnancy, as it may increase stress during pregnancy and affect birth outcomes. Data were obtained from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Participants were recruited from December 2006 to June 2011 and included 1,448 pregnant women. The average gestational age at enrollment was 23 weeks. The primary outcome of residential mobility was defined as any change in address during pregnancy...
September 18, 2017: Women & Health
https://www.readbyqxmd.com/read/28916016/comparing-two-models-of-integrated-behavioral-health-programs-in-pediatric-primary-care
#8
REVIEW
Miguelina Germán, Michael L Rinke, Brittany A Gurney, Rachel S Gross, Diane E Bloomfield, Lauren A Haliczer, Silvie Colman, Andrew D Racine, Rahil D Briggs
This study examined how to design, staff, and evaluate the feasibility of 2 different models of integrated behavioral health programs in pediatric primary care across primary care sites in the Bronx, NY. Results suggest that the Behavioral Health Integration Program model of pediatric integrated care is feasible and that hiring behavioral health staff with specific training in pediatric, evidence-informed behavioral health treatments may be a critical variable in increasing outcomes such as referral rates, self-reported competency, and satisfaction...
October 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28910226/the-bacterial-renaissance-a-supply-side-answer-to-the-icarus-paradox-of-antibiotic-usage-undermining-its-own-usefulness
#9
Gurney Fields Pearsall
No abstract text is available yet for this article.
January 2017: Journal of Legal Medicine
https://www.readbyqxmd.com/read/28874573/redefining-community-based-on-place-attachment-in-a-connected-world
#10
Georgina G Gurney, Jessica Blythe, Helen Adams, W Neil Adger, Matthew Curnock, Lucy Faulkner, Thomas James, Nadine A Marshall
The concept of community is often used in environmental policy to foster environmental stewardship and public participation, crucial prerequisites of effective management. However, prevailing conceptualizations of community based on residential location or resource use are limited with respect to their utility as surrogates for communities of shared environment-related interests, and because of the localist perspective they entail. Thus, addressing contemporary sustainability challenges, which tend to involve transnational social and environmental interactions, urgently requires additional approaches to conceptualizing community that are compatible with current globalization...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28870067/versatile-device-architectures-for-high-performing-light-soaking-free-inverted-polymer-solar-cells
#11
Yu Yan, Feilong Cai, Liyan Yang, Wei Li, Yanyan Gong, Jinlong Cai, Shuang Liu, Robert S Gurney, Dan Liu, Tao Wang
Metal oxide charge transport layers have been widely employed to prepare inverted polymer solar cells with high efficiency and long lifetime. However, the intrinsic defects in the metal oxide layers, especially those prepared from low-temperature routes, overshadow the high efficiency that can be achieved and also introduce "light-soaking" issues to these devices. In this work, we have employed polyethyleneimine (PEI) and poly(9,9-bis(6'-(N,N-diethylamino)propyl)-fluorene-alt-9,9-bis-(3-ethyl(oxetane-3-ethyloxy)-hexyl)-fluorene] (PFN-OX) to modify our low-temperature-processed TiO2 electron transport layer (ETL) and demonstrated that the light-soaking issue can be effectively eliminated by PEI modifications because of the formation of abundant dipole moments, whereas PFN-OX was ineffective as a result of deficient dipole moments at the interface...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28834281/cytoreductive-nephrectomy-for-metastatic-renal-cell-carcinoma-inequities-in-access-exist-despite-improved-survival
#12
Manish I Patel, Kieran Beattie, Albert Bang, Howard Gurney, David P Smith
The use of cytoreductive nephrectomy (CRN) in the targeted therapy era is still debated. We aimed to determine factors associated with reduced use of CRN and determine the effect of CRN on overall survival in patients with metastatic renal cell carcinoma (RCC). All advanced RCC diagnosed between 2001 and 2009 in New South Wales, Australia, were identified from the Central Cancer Registry. Records of treatment and death were electronically linked. Follow-up was to the end of 2011. Multivariable logistic regression analysis was used to determine factors associated with the receipt of CRN...
October 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28831035/molecular-phylogeny-and-revision-of-copepod-orders-crustacea-copepoda
#13
Sahar Khodami, J Vaun McArthur, Leocadio Blanco-Bercial, Pedro Martinez Arbizu
For the first time, the phylogenetic relationships between representatives of all 10 copepod orders have been investigated using 28S and 18S rRNA, Histone H3 protein and COI mtDNA. The monophyly of Copepoda (including Platycopioida Fosshagen, 1985) is demonstrated for the first time using molecular data. Maxillopoda is rejected, as it is a polyphyletic group. The monophyly of the major subgroups of Copepoda, including Progymnoplea Lang, 1948 (=Platycopioida); Neocopepoda Huys and Boxshall, 1991; Gymnoplea Giesbrecht, 1892 (=Calanoida Sars, 1903); and Podoplea Giesbrecht, 1892, are supported in this study...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798678/striatal-neuropeptides-enhance-selection-and-rejection-of-sequential-actions
#14
David Buxton, Enrico Bracci, Paul G Overton, Kevin Gurney
The striatum is the primary input nucleus for the basal ganglia, and receives glutamatergic afferents from the cortex. Under the hypothesis that basal ganglia perform action selection, these cortical afferents encode potential "action requests." Previous studies have suggested the striatum may utilize a mutually inhibitory network of medium spiny neurons (MSNs) to filter these requests so that only those of high salience are selected. However, the mechanisms enabling the striatum to perform clean, rapid switching between distinct actions that form part of a learned action sequence are still poorly understood...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28741687/a-distinct-plasma-lipid-signature-associated-with-poor-prognosis-in-castration-resistant-prostate-cancer
#15
Hui-Ming Lin, Kate L Mahon, Jacquelyn M Weir, Piyushkumar A Mundra, Calan Spielman, Karen Briscoe, Howard Gurney, Girish Mallesara, Gavin Marx, Martin R Stockler, PRIMe Consortium, Robert G Parton, Andrew J Hoy, Roger J Daly, Peter J Meikle, Lisa G Horvath
Lipids are known to influence tumour growth, inflammation and chemoresistance. However, the association of circulating lipids with the clinical outcome of metastatic castration-resistant prostate cancer (CRPC) is unknown. We investigated associations between the plasma lipidome and clinical outcome in CRPC. Lipidomic profiling by liquid chromatography-tandem mass spectrometry was performed on plasma samples from a Phase 1 discovery cohort of 96 CRPC patients. Results were validated in an independent Phase 2 cohort of 63 CRPC patients...
July 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28691093/wnt-antagonists-exhibit-unique-combinatorial-antitumor-activity-with-taxanes-by-potentiating-mitotic-cell-death
#16
Marcus M Fischer, Belinda Cancilla, V Pete Yeung, Fiore Cattaruzza, Cecile Chartier, Christopher L Murriel, Jennifer Cain, Raymond Tam, Chieh-Yang Cheng, James W Evans, Gilbert O'Young, Xiaomei Song, John Lewicki, Ann M Kapoun, Austin Gurney, Wan-Ching Yen, Timothy Hoey
The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers through a variety of genetic and epigenetic mechanisms. Targets in the WNT pathway are being extensively pursued for the development of new anticancer therapies, and we have advanced two WNT antagonists for clinical development: vantictumab (anti-FZD) and ipafricept (FZD8-Fc). We examined the antitumor efficacy of these WNT antagonists in combination with various chemotherapies in a large set of patient-derived xenograft models...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28687178/a-randomized-pilot-evaluation-of-individual-level-abortion-stigma-resulting-from-pennsylvania-mandated-abortion-counseling
#17
Sarita Sonalkar, Elizabeth P Gurney, Arden McAllister, Courtney A Schreiber
OBJECTIVE: The objective was to investigate the effect of mandated abortion counseling requirements intended to dissuade women from having abortions on patients' individual-level abortion stigma. METHODS: We randomized women presenting for abortion to complete a demographic survey and the validated Individual Level Abortion Stigma (ILAS) scale either before (unexposed) or after (exposed) hearing the mandatory Pennsylvania Abortion Control Act counseling via a standardized video...
July 4, 2017: Contraception
https://www.readbyqxmd.com/read/28667354/dose-individualization-of-sunitinib-in-metastatic-renal-cell-cancer-toxicity-adjusted-dose-or-therapeutic-drug-monitoring
#18
Dhanusha Sabanathan, Alison Zhang, Peter Fox, Sally Coulter, Val Gebski, Bavanthi Balakrishnar, Mathew Chan, Christopher Liddle, Howard Gurney
PURPOSE: Dose individualization of sunitinib has been proposed using therapeutic drug monitoring (TDM) or toxicity-adjusted dose (TAD). We prospectively studied aspects of TDM and TAD to inform future trials, namely (1) intrapatient variability (CV) of sunitinib and (2) feasibility of a TAD protocol. METHODS: Sunitinib dose was adjusted to ensure grade 1 or 2 toxicity on 10-20 days of each 42-day cycle. Total trough levels (TTL) C min of sunitinib and its active metabolite were measured every 6 weeks...
August 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28654092/risk-factors-for-cryptorchidism
#19
REVIEW
Jason K Gurney, Katherine A McGlynn, James Stanley, Tony Merriman, Virginia Signal, Caroline Shaw, Richard Edwards, Lorenzo Richiardi, John Hutson, Diana Sarfati
Undescended testis - known as cryptorchidism - is one of the most common congenital abnormalities observed in boys, and is one of the few known risk factors for testicular cancer. The key factors that contribute to the occurrence of cryptorchidism remain elusive. Testicular descent is thought to occur during two hormonally-controlled phases in fetal development - between 8-15 weeks (the first phase of decent) and 25-35 weeks gestation (the second phase of descent); the failure of a testis to descend permanently is probably caused by disruptions to one or both of these phases, but the causes and mechanisms of such disruptions are still unclear...
September 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28649702/dose-considerations-for-anti-cancer-drugs-in-metastatic-prostate-cancer
#20
REVIEW
Megan Crumbaker, Howard Gurney
Despite a growing number of treatment options, metastatic castrate resistant prostate cancer remains almost universally fatal. Dose individualization ensures patients receive the maximal benefit from each line of treatment potentially leading to improved outcomes, a reduction in quality of life impairment and minimization of premature cessation for avoidable toxicity. Herein, we review drug-specific issues that may be associated with unexpected or unrecognized variations in drug systemic exposure despite the use of protocol doses...
August 2017: Prostate
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