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Ana Hernández-Pellón, Ignacio Fernández-Olmo, Frédéric Ledoux, Lucie Courcot, Dominique Courcot
Numerous studies have associated air manganese (Mn) exposure with negative health effects, primarily neurotoxic disorders. Despite there is not a specific European regulation, institutions such as the World Health Organization (WHO) have proposed an annual average guideline value of 150 ng/m(3). Bioaccessibility and toxicity mechanisms of Mn remain unclear, however it is generally agreed that adverse health effects are strongly linked to particle size and morphology, chemical composition and oxidation state...
February 10, 2017: Chemosphere
Andre Banning, Nadine Pawletko, Julia Röder, Christine Kübeck, Frank Wisotzky
Uranium (U) concentrations in groundwater extracted for drinking water usage from a Quaternary fluvial aquifer partly exceed the German drinking water guideline of 10μgL(-1). Responsible sources and mobilization processes were unknown and gave rise to this study. Land use of the watershed is mainly agricultural leading to groundwater nitrate concentrations >50mgL(-1) and a need for water treatment prior to utilization as drinking water. This is successfully accomplished by addition of nutrients triggering bacterial nitrate reduction, followed by the addition of NaOH for water softening and CO2 for pH adjustment, with subsequent reinfiltration into the aquifer...
February 23, 2017: Science of the Total Environment
Cory H T Boone, Ryan A Grove, Dana Adamcova, Javier Seravalli, Jiri Adamec
The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations, and genetics leading to the clinically observed adverse effects have not been temporally characterized. To study alterations that may lead to these undesirable effects, Saccharomyces cerevisiae grown on aerobic carbon sources to stationary phase was assessed over 6h...
February 3, 2017: Redox Biology
E M van Es, B C Russell, P Ivanov, D Read
A novel and rapid method has been developed for pre-concentration and measurement of (226)Ra in groundwater and discharge water samples using the latest generation triple quadrupole inductively coupled plasma mass spectrometry (ICP-QQQ-MS). Cation exchange and extraction chromatography are capable of pre-concentration factors of ~200 based on 1L samples. The sensitivity and interference removal capability of ICP-QQQ-MS was assessed from spiked groundwaters, with the introduction of He collision gas required to minimise instrument background in high-matrix samples...
February 20, 2017: Applied Radiation and Isotopes
Gökçe Kaya, Semra Türkoğlu
Concentrations of toxic metals (Mn, Ni, Hg, Cd, Pb, Cr) in the muscle, skin, and liver of Mugil cephalus, Mullus barbatus, and Pagellus erythrinus which were purchased in large supermarkets of Elazig, and Mullus barbatus, which were caught on the sea of İskenderun Bay, Turkey, were analyzed. Fundamental analyses were carried out by inductively coupled plasma-mass spectrometry (ICP-MS) after samples were prepared by microwave digestion. Mean metal concentrations in different tissues were varied in the ranges of Cd 4-426, Cr 116-4458, Mn 141-24774, Hg 9-471, Pb 96-695, and Ni 68-6581 μg kg(-1), for wet weight...
February 25, 2017: Environmental Science and Pollution Research International
Edoardo Picetti, Maria Luisa Caspani, Corrado Iaccarino, Giulia Pastorello, Pierpaolo Salsi, Edoardo Viaroli, Franco Servadei
BACKGROUND: Intracranial pressure (ICP) monitoring represents an important tool in the management of traumatic brain injury (TBI). Although current information exists regarding ICP monitoring in secondary decompressive craniectomy (DC), little is known after primary DC following emergency hematoma evacuation. METHODS: Retrospective analysis of prospectively collected data. Inclusion criteria were age ≥18 years and admission to the intensive care unit (ICU) for TBI and ICP monitoring after primary DC...
February 24, 2017: Acta Neurochirurgica
Jawad Ali Hussein Alpofead, Christine M Davidson, David Littlejohn
A novel two-step sequential extraction has been developed to assess the bioaccessibility of As, Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn in airborne particulate matter following inhalation and transport into the human gastrointestinal tract by mucociliary clearance. A new artificial mucus fluid (AMF) was used to determine the bioaccessible potentially toxic element (PTE) fraction in the upper airways, in sequence with the simplified bioaccessibility extraction test (SBET) or the stomach phase of the unified bioaccessibility method (gastric fluid only) (UBMG)...
February 24, 2017: Analytical and Bioanalytical Chemistry
Karina Marshall-Goebel, Edwin Mulder, Dorit Donoviel, Gary Strangman, Jose I Suarez, Chethan Venkatasubba Rao, Petra Frings-Meuthen, Ulrich Limper, Jörn Rittweger, Eric M Bershad
Exposure to the microgravity environment results in various adaptive and maladaptive physiological changes in the human body, with notable ophthalmic abnormalities developing during 6-month missions on the International Space Station (ISS). These findings have led to the hypothesis that the loss of gravity induces a cephalad fluid shift, decreased cerebral venous outflow and increased intracranial pressure (ICP) which may be further exacerbated by increased ambient carbon dioxide (CO2) levels on the ISS. Here we describe the "SPACECOT study" (Studying the Physiological and Anatomical Cerebral Effects of CO2 during Head-Down Tilt), a randomized, double-blinded cross-over design study with two conditions: 29 h of 12° head-down tilt (HDT) with ambient air and 29 h of 12° HDT with 0...
February 23, 2017: Journal of Applied Physiology
Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang, Sae Woong Kim
BACKGROUND: Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidative stress damage in the vascular endothelium and erectile tissue. KH-204 is an herbal formula with a strong antioxidant effect. We evaluated the effects of KH-204 on erectile function in a rat model of HC-induced ED. METHODS: Male Sprague-Dawley rats (6 weeks old) were divided into normal control, high-fat and cholesterol diet (HFC), and HFC with KH-204 treatment (HFC + KH) groups (n = 12 each)...
February 24, 2017: BMC Complementary and Alternative Medicine
Aniket Kumar, Lipeeka Rout, Lakkoji Satish Kumar Achary, Rajendra S Dhaka, Priyabrat Dash
A facile, efficient and environmentally-friendly protocol for the synthesis of xanthenes by graphene oxide based nanocomposite (GO-CuFe2O4) has been developed by one-pot condensation route. The nanocomposite was designed by decorating copper ferrite nanoparticles on graphene oxide (GO) surface via a solution combustion route without the use of template. The as-synthesized GO-CuFe2O4 composite was comprehensively characterized by XRD, FTIR, Raman, SEM, EDX, HRTEM with EDS mapping, XPS, N2 adsorption-desorption and ICP-OES techniques...
February 24, 2017: Scientific Reports
Zhong Chen, Zongji Shen, Lingqing Hu, Mudan Lu, Yizhong Feng
Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disease uniquely occurring during pregnancy. In this study we aimed to identify novel biomarker for the diagnosis of ICP in Chinese population. 50 healthy pregnant women, 50 mild ICP patients and 48 severe ICP patients were enrolled for this study. Liver function tests, including serum total bilirubin, direct bilirubin, alanine transaminase, aspartate aminotransferase and cholyglycine, were performed in all participants. After an overnight fast serum levels of total bile acids (TBA), matrix metalloproteinase (MMP)-2 and MMP-9 were measured, and their correlation with liver function tests were analyzed...
February 15, 2017: Annals of Hepatology
C Larijani, A K Pearce, P H Regan, B C Russell, S M Jerome, M T Crespo, P de Felice, G Lutter, F Maringer, M Mazánová
Reliable measurement of Naturally Occurring Radioactive Materials is of significance in order to comply with environmental regulations and for radiological protection purposes. This paper discusses the standardisation of three reference materials, namely sand, tuff and TiO2 to serve as quality control materials for traceability, method validation and instrument calibration. The sample preparation, material characterization via γ, α and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and the assignment of values for both the 4n (Thorium) and 4n+2 (Uranium) decay series are described...
February 8, 2017: Applied Radiation and Isotopes
Esra Bağda, Hüseyin Altundağ, Mustafa Soylak
In the present work, simple and sensitive extraction methods for selective determination of manganese have been successfully developed. The methods were based on solubilization of manganese in deep eutectic solvent medium. Three deep eutectic solvents with choline chloride (vitamin B4) and tartaric/oxalic/citric acids have been prepared. Extraction parameters were optimized with using standard reference material (1573a tomato leaves). The quantitative recovery values were obtained with 1.25 g/L sample to deep eutectic solvent (DES) volume, at 95 °C for 2 h...
February 23, 2017: Biological Trace Element Research
Ying Zhou, Hongyan Li, Hongzhe Sun
A novel strategy using cisplatin as a viability dye together with conjugating lanthanide tags to marker proteins was developed to examine As2O3 cytotoxicity in single NB4/HL60 cells via ICP-MS. A positive correlation among intracellular arsenic contents, the ratios of apoptosis and death cells provides a basis for the design of more effective arsenic drugs.
February 24, 2017: Chemical Communications: Chem Comm
Kihong Kim, Wonseok Kim, Hyekyung Lee, Sung Jae Kim
Ion concentration polarization (ICP) has been extensively researched concerning new fundamentals in nanoscale electrokinetics and novel engineering applications. While biomedical and environmental ICP applications have a number of advantages compared to conventional methods, the technique has suffered from the critical limitation of low processing capacity because it has been usually presented in a micro/nanofluidic platform. In this paper, we devised micro fin structures inside a macroscale high-throughput ICP device and successfully demonstrated a stable formation of ICP layer and its performance...
February 24, 2017: Nanoscale
Konstantin Hockel, Jennifer Diedler, Jochen Steiner, Ulrich Birkenhauer, Ulrike Ernemann, Martin U Schuhmann
BACKGROUND: For the treatment and prevention of delayed cerebral ischemia after subarachnoid hemorrhage the vasodilating agent nimodipine (NDP) is widely employed. This study investigates the effect of NDP on the cerebrovascular autoregulation, assessed by pressure reactivity index (PRx), and brain tissue oxygenation (pbrO2) when given continuous intravenously, as intra-arterial bolus or during continuous intra-arterial therapy. METHODS: Computerized continuous neuromonitoring-data (ICP, MAP, CPP, pbrO2, PRx) of 105 patients with aneurysmal SAH were retrospectively evaluated...
February 13, 2017: World Neurosurgery
Viviana Vergaro, Paride Papadia, Paola Petrini, Francesco Paolo Fanizzi, Laura Pastorino, Giuseppe Ciccarella
Carbohydrate polimeric microcapsules were assembled using a LbL approach onto a CaCO3 core. The microcapsules were used to delivery the anticancer drug cisplatin into HeLa and MCF-7 cancer cell lines. Drug encapsulation, measured by ICP spectroscopy, was around 50% of the charging solution. Fluorimetric measurements showed an efficient cellular uptake of polysacchardic microcapsules in both cell lines. The drug-loaded capsules demonstrated a better efficiency against cell viability than the free drug. Specifically, the amount of platinum reaching genomic DNA was measured, showing that encapsulation improves the nuclear delivery of the drug for both cell lines...
February 19, 2017: International Journal of Biological Macromolecules
Md Moshfekus Saleh-E-In, Nasim Sultana, Md Matiur Rahim, Md Aminul Ahsan, Md Nurul Huda Bhuiyan, Md Nur Hossain, Md Mahbubar Rahman, Sudhangshu Kumar Roy, Md Rabiul Islam
BACKGROUND: Medicinal herbs are used for the treatment of different ailments since antiquity. Different parts of Anethum sowa L. is used in folk medicine as a carminative for the treatment of flatulence, colic and hiccups of infants and children, antioxidant, antimicrobial and antispasmodic agent. The aim of our present study is to evaluate the chemical composition of the essential oil, proximate and elemental composition, amino acid, fatty acid profile and thermal behaviour of its root part as well as different pharmacological activities like antioxidant, antimicrobial and cytotoxicity of the root essential oil...
February 23, 2017: BMC Complementary and Alternative Medicine
Rossella Vadalà, Antonio F Mottese, Giuseppe D Bua, Andrea Salvo, Domenico Mallamace, Carmelo Corsaro, Sebastiano Vasi, Salvatore V Giofrè, Maria Alfa, Nicola Cicero, Giacomo Dugo
We performed a statistical analysis of the concentration of mineral elements, by means of inductively coupled plasma mass spectrometry (ICP-MS), in different varieties of garlic from Spain, Tunisia, and Italy. Nubia Red Garlic (Sicily) is one of the most known Italian varieties that belongs to traditional Italian food products (P.A.T.) of the Ministry of Agriculture, Food, and Forestry. The obtained results suggest that the concentrations of the considered elements may serve as geographical indicators for the discrimination of the origin of the different samples...
March 15, 2016: Foods (Basel, Switzerland)
Raquel Sanchez, Burkhard Horstkotte, Katerina Fikarova, Hana Sklenářová, Salvador Maestre, Manuel Miró, José Luis Todoli
A proof of concept study involving the on-line coupling of automatic dispersive liquid-liquid microextraction (DLLME) to ICP OES with direct introduction and analysis of the organic extract is herein reported for the first time. The flow-based analyzer features a Lab-In-Syringe (LIS) setup with an integrated stirring system, a Meinhard® nebulizer in combination with a heated single-pass spray chamber, and a rotary injection valve, used as on-line interface between the microextraction system and the detection instrument...
February 23, 2017: Analytical Chemistry
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