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https://www.readbyqxmd.com/read/29905376/a-prospective-study-of-dietary-polyunsaturated-fatty-acids-intake-and-lung-cancer-risk
#1
Hung N Luu, Hui Cai, Harvey J Murff, Yong-Bing Xiang, Qiuyin Cai, Honglan Li, Jing Gao, Gong Yang, Qing Lan, Yu-Tang Gao, Wei Zheng, Xiao-Ou Shu
Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men)...
June 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29904333/grape-seed-proanthocyanidin-extract-supplementation-affects-exhaustive-exercise-induced-fatigue-in-mice
#2
Liu Xianchu, Liu Ming, Liu Xiangbin, Zheng Lan
Background: Grape seed proanthocyanidin extract (GSPE) has been extensively reported to possess a wide range of beneficial properties in multiple tissue damage. Previous studies have shown that exhaustive exercise-induced fatigue associates with oxidative stress injury, inflammatory response, and mitochondrial dysfunction. Objective: The aim of this study is to investigate the anti-fatigue effects of GSPE in mice and explore its possible underlying mechanism. Design: The mouse model of exhaustive exercise-induced fatigue was established by using the forced swimming test, and GSPE was orally treated for successive 28 days at 0, 1, 50 and 100 mg/kg/day of body weight, designated the control, GSPE-L, GSPE-M and GSPE-H groups, respectively...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29902071/anti-inflammatory-effects-of-melatonin-a-mechanistic-review
#3
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Janbo Xiao, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Alessandra Baldi, Haroon Khan, Maria Daglia
N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In humans, melatonin participates in numerous functions including the regulation of mood, sleep, reproduction, promotion of immunomodulation, antioxidant defense and as an anti-inflammatory agent. The anti-inflammatory activity of melatonin could yield beneficial effects on intake, particularly against the chronic inflammation which underlies many chronic diseases...
June 14, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29898649/bpc157-as-potential-agent-rescuing-from-cancer-cachexia
#4
Eun A Kang, Young Min Han, Jeong Min An, Yong Jin Park, Predrag Sikiric, Deok Hwan Kim, Kwang An Kwon, Yoon Jae Kim, Donghwa Yang, Hann Tchah, Ki Baik Hahm
Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal cancer patients presenting with significant weight loss associated with skeletal muscle atrophy and fat loss. Though cachexia may account for up to 20% of cancer deaths, no significant treatment is still lacking and is of urgent unmet medical need in cancer treatment. Therefore, understanding the underlying molecular mechanisms is essential for anticipating therapeutic approaches...
June 13, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29892131/antioxidant-and-anti-inflammatory-capacities-of-collagen-peptides-from-milkfish-chanos-chanos-scales
#5
Yu-Pei Chen, Chia-Hua Liang, Hong-Tan Wu, Hai-Yue Pang, Chuan Chen, Guey-Horng Wang, Leong-Perng Chan
Milkfish ( Chanos chanos ), which is resistant to water quality changes is the fourth largest aquaculture commodity. Abandoned wastes of fish scale and bones aggravate environmental pollution. In this study, the effect of collagen peptides isolated from milkfish scales (MSCP) by pepsin-soluble collagen method on cell viability was investigated. The antioxidant, anti-inflammatory, and DNA-protective activities of MSCP were also evaluated. Results revealed that more than 95% of viable cells were retained in human keratinocytes after addition of 100 mg/mL MSCP...
June 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29892102/bioaccessibility-of-hydroxycinnamic-acids-and-antioxidant-capacity-from-sorghum-bran-thermally-processed-during-simulated-in-vitro-gastrointestinal-digestion
#6
Norma Julieta Salazar-López, Gustavo A González-Aguilar, Ofelia Rouzaud-Sández, Maribel Robles-Sánchez
Sorghum is a source of hydroxycinnamic acids (HCA), which have shown antioxidant, anti-inflammatory and anti-proliferative capacities. However, a high proportion of them have low bioaccessibility due the complex structural disposition of the plant's cell wall. The effects of boiling and extrusion processes on sorghum bran and their effects on the antioxidant capacity and bioaccessibility of HCA during simulated in vitro gastrointestinal digestion were investigated. The bioaccessibility of phenolic compounds was significantly higher in extruded sorghum bran (38...
June 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29891812/structure%C3%A2-activity-relationship-of-the-tyrosinase-inhibitors-kuwanon-g-mulberrofuran-g-and-albanol-b-from-morus-species-a-kinetics-and-molecular-docking-study
#7
Prashamsa Koirala, Su Hui Seong, Yajuan Zhou, Srijan Shrestha, Hyun Ah Jung, Jae Sue Choi
Kuwanon G (KG) and benzofuran flavonoids such as mulberrofuran G (MG) and albanol B (AB) isolated from Morus sp. are reported to exhibit anti-Alzheimer’s disease, anti-inflammatory, fungicidal, anti-cancer, anti-bacterial, and anti-tyrosinase properties. We investigated the inhibition of mono- and diphenolase activity of mushroom tyrosinase by KG, MG, and AB. KG and MG displayed acceptable inhibition activity compared to kojic acid. AB did not show any activity up to 350 µM. MG displayed six-fold higher inhibition of l -tyrosine oxidation (IC50 = 6...
June 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29890691/design-synthesis-anticancer-evaluation-and-docking-studies-of-novel-heterocyclic-derivatives-obtained-via-reactions-involving-curcumin
#8
Rita M Borik, Nagwa M Fawzy, Sherifa M Abu-Bakr, Magdy S Aly
Curcumin, a widely utilized flavor and coloring agent in food, has been shown to demonstrate powerful antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo. In the present work, synthesis of new heterocyclic derivatives based on Curcumin was studied. Compound 3 was synthesized via the reaction of furochromone carbaldehyde ( 1 ) with Curcumin ( 2 ) using pipredine as catalyst. Also, novel, 4,9-dimethoxy-5 H -furo [3, 2- g ] chromen-5-one derivatives 4a ⁻ d , 6a ⁻ d , 7 , 8a ⁻ d , 9 and 10 were synthesized by the reactions of furochromone carbaldehyde ( 1 ) with different reagents (namely: appropriate amine 3a ⁻ d , appropriate hydrazine 5a ⁻ d , hydroxylamine hydrochloride, urea/thiourea, malononitrile, malononitrile with hydrazine hydrate)...
June 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29889141/interaction-between-foods-and-nonsteroidal-anti-inflammatory-drugs-and-exercise-in-the-induction-of-anaphylaxis
#9
Joan Bartra, Giovanna Araujo, Rosa Muñoz-Cano
PURPOSE OF REVIEW: To assess the studies that focus on the study of food-dependent exercise-induced anaphylaxis (FDEIA) and food-dependent NSAID-induced anaphylaxis (FDNIA). RECENT FINDINGS: Cofactors, as exercise and nonsteroidal anti-inflammatory drugs (NSAIDs), are relevant in up to 30% of episodes of anaphylaxis. Gliadin and lipid transfer proteins are the main allergens involved. The attempts to reproduce FDEIA and FDNIA in a controlled setting have an important failure rate...
June 7, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29885599/naringenin-is-an-inhibitor-of-t-cell-effector-functions
#10
Xinli Niu, Chunfang Wu, Mengyue Li, Qing Zhao, Simin Nikbin Meydani, Junpeng Wang, Dayong Wu
Selective inhibition of T cells has been implied to prevent and/or treat autoimmune and inflammatory diseases. Some food compounds that have such immune-modulating functions may serve as nutritional approach to this purpose. In this study, we chose naringenin, a citrus fruits-derived compound with antiinflammatory property, to test this possibility. In this in vitro study, we stimulated mouse T cells with anti-CD3/CD28 (polyclonal TCR activation) or autoantigen MOG35-55 in the presence of naringenin. We found that naringenin dose-dependently suppressed anti-CD3/CD28 and MOG35-55 -induced T cell proliferation, production of T cell cytokines IFN-γ, IL-17, IL-6 and TNF-α...
April 25, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29883523/current-insights-into-the-biological-action-of-squalene
#11
REVIEW
José M Lou-Bonafonte, Roberto Martínez-Beamonte, Teresa Sanclemente, Joaquín C Surra, Luis V Herrera-Marcos, Javier Sanchez-Marco, Carmen Arnal, Jesús Osada
Squalene is a triterpenic compound found in a large number of plants and other sources with a long tradition of research since it was first reported in 1926. Herein we present a systematic review of studies concerning squalene published in the last eight years. These studies have provided further support for its antioxidant, anti-inflammatory and anti-atherosclerotic properties in vivo and in vitro. Moreover, an anti-neoplastic effect in nutrigenetic-type treatments, which depend on the failing metabolic pathway of tumors, has also been reported...
June 8, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29873345/saxs-characterization-of-the-interactions-among-digested-food-compounds-and-the-anti-oxidant-and-anti-inflammatory-activities-of-the-formed-nanocomplexes
#12
Yingkang Yang, Xiaoqi Wang, Guijie Chen, Wenhua Zhou, Xiaoxiong Zeng, Bing Hu, Yunqi Li, Qingrong Huang
In the present study, small angle X-ray scattering (SAXS) is applied to investigate the interaction between caseinophosphopeptides (CPP), the major digested product of milk protein, and chitosan (CS) under simulated gastrointestinal (GI) pH conditions. The change in pH value from the gastric to small intestinal environment induces complexation between CPP and CS, which is mainly driven by electrostatic interactions. The fractal dimension (Df) value of the domains inside the CPP-CS complexes is greater than 3, indicating the formation of dense particles/aggregates at the nanoscale...
June 6, 2018: Food & Function
https://www.readbyqxmd.com/read/29872261/antihyperglycemic-and-anti-inflammatory-effects-of-fermented-food-paste-in-high-fat-diet-and-streptozotocin-challenged-mice
#13
Noraisyah Zulkawi, Kam Heng Ng, Nur Rizi Zamberi, Swee Keong Yeap, Dilan A Satharasinghe, Sheau Wei Tan, Wan Yong Ho, Nur Yuhasliza Abd Rashid, Mohd Izwan Md Lazim, Anisah Jamaluddin, Noorjahan Banu Alitheen, Kamariah Long
Background: Fermented food has been widely consumed as health food to ameliorate or prevent several chronic diseases including diabetes. Xeniji™, a fermented food paste (FFP), has been previously reported with various bioactivities, which may be caused by the presence of several metabolites including polyphenolic acids, flavonoids, and vitamins. In this study, the anti-hyperglycemic and anti-inflammatory effects of FFP were assessed. Methods: In this study, type 2 diabetes model mice were induced by streptozotocin and high-fat diet (HFD) and used to evaluate the antihyperglycemic and anti-inflammatory effects of FFP...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29870039/buckwheat-and-buckwheat-enriched-products-exert-an-anti-inflammatory-effect-on-the-myofibroblasts-of-colon-ccd-18co
#14
J A Giménez-Bastida, J M Laparra-Llopis, N Baczek, H Zielinski
Buckwheat (BW) constitutes a good source of bioactive components that show anti-inflammatory effects in vitro and in vivo. The use of functional foods in the prevention and treatment of inflammatory bowel diseases (IBDs) has aroused increasing interest. This study investigates the effect of in vitro digested BW and BW-enriched products (BW-enriched wheat breads, roasted BW groats -fermented and non-fermented-, and BW sprouts) on colon myofibroblasts, the cells involved in the regulation of inflammatory response in the intestine...
June 5, 2018: Food & Function
https://www.readbyqxmd.com/read/29868331/atopic-dermatitis-early-treatment-in-children
#15
Amy Huang, Christine Cho, Donald Y M Leung, Kanwaljit Brar
Therapeutic regimens for the treatment and long-term management of AD traditionally had a two-fold objective of decreasing skin inflammation and repairing the defective skin barrier. Essential treatments for AD in children should include topical moisturizers for skin hydration and prevention of flares, topical anti-inflammatory medications (e.g. corticosteroids, calcineurin inhibitors, PDE4 inhibitor), allergen/irritant avoidance, and treatment of skin infections. Treatment regimens should be severity-based, and implemented in a stepwise approach tailored to the individual patient...
September 2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/29864626/anticancer-and-other-therapeutic-relevance-of-mushroom-polysaccharides-a-holistic-appraisal
#16
REVIEW
Damini Kothari, Seema Patel, Soo-Ki Kim
The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario of increasing instances of metabolic syndromes. In this direction, mushroom polysaccharides have shown immense promise. Scores of studies have characterized and evaluated their biological relevance, which range from antioxidant, anti-inflammatory, anticancer, antidiabetic, antimicrobial, and antilipemic to immunomodulatory. Hence, it is important to accumulate the key findings of these investigations, and to apply the insights to develop functional foods, and immunomodulators...
June 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29862274/benralizumab-from-the-basic-mechanism-of-action-to-the-potential-use-in-the-biological-therapy-of-severe-eosinophilic-asthma
#17
REVIEW
Corrado Pelaia, Cecilia Calabrese, Alessandro Vatrella, Maria Teresa Busceti, Eugenio Garofalo, Nicola Lombardo, Rosa Terracciano, Girolamo Pelaia
Asthma is a very frequent chronic airway disease that includes many different clinical phenotypes and inflammatory patterns. In particular, eosinophilic bronchial inflammation is often associated with allergic as well as nonallergic asthma. The most important cytokine involved in the induction, maintenance, and amplification of airway eosinophilia in asthma is interleukin-5 (IL-5), released by both T helper 2 (Th2) lymphocytes and group 2 innate lymphoid cells (ILC2). Hence, IL-5 and its receptor are suitable targets for selective biologic drugs which can play a key role in add-on treatment of severe eosinophilic asthma refractory to corticosteroids...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29861773/the-flavonoid-jaceosidin-from-artemisia-princeps-induces-apoptotic-cell-death-and-inhibits-the-akt-pathway-in-oral-cancer-cells
#18
Hye-Yeon Han, Hyung Joon Kim, Seung-Hwa Jeong, Jiyeon Kim, Sung-Hee Jeong, Gyoo Cheon Kim, Dae-Seok Hwang, Uk-Kyu Kim, Mi Heon Ryu
Jaceosidin is a single compound from the Japanese mugwort Artemisia princeps , which is used as a food and a traditional medicinal herb. A. princeps extracts and flavonoid components have been shown to have antihyperglycaemic, antioxidant, and anti-inflammatory properties. Although the anticancer properties of these extracts were recently demonstrated, the related mechanisms have not been characterised. In this study, we investigated the effects of jaceosidin in oral squamous cell carcinoma (OSCC) cells and initially showed selective suppression of proliferation (IC50 = 82...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29861448/the-efficacy-of-mag-dha-for-correcting-aa-dha-imbalance-of-cystic-fibrosis-patients
#19
Caroline Morin, André M Cantin, Félix-Antoine Vézina, Samuel Fortin
Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementations are thought to improve essential fatty acid deficiency (EFAD) as well as reduce inflammation in Cystic Fibrosis (CF), but their effectiveness in clinical studies remains unknown. The aim of the study was to determine how the medical food containing docosahexaenoic acid monoglyceride (MAG-DHA) influenced erythrocyte fatty acid profiles and the expression levels of inflammatory circulating mediators. We conducted a randomized, double blind, pilot trial including fifteen outpatients with Cystic Fibrosis, ages 18⁻48...
May 26, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29860899/histopathological-immunohistochemical-and-biomechanical-effects-of-splenectomy-on-achilles-tendon-healing-in-rats
#20
Serdar Yuksel, M Akif Guleç, Zeki Gultekin, Aysel Caglar, Ozan Beytemur, Ender Alagoz, A Akdogan Eker, Cansu Subaşı, Erdal Karaoz
PURPOSE: This study aimed to assess Achilles tendon repair in rats following splenectomy to simulate patients with musculoskeletal system injury who had splenectomy after spleen injury, a situation often seen in orthopedics and traumatology practice. MATERIALS AND METHODS: The study included 32 male Sprague-Dawley rats (10 months old; average weight, 394.5 ± 28.3 g). The rats were fed with standard rodent food ad libitum at 22°C in a dark environment for 12 h...
June 4, 2018: Connective Tissue Research
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