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https://www.readbyqxmd.com/read/28432476/immunological-mechanisms-of-adsorptive-cytapheresis-in-inflammatory-bowel-disease
#1
REVIEW
Esteban Sáez-González, Inés Moret, Diego Alvarez-Sotomayor, Francia Carolina Díaz-Jaime, Elena Cerrillo, Marisa Iborra, Pilar Nos, Belén Beltrán
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). The study of immunological pathways involved in the onset of IBD is of fundamental importance to identify potential biological markers of disease activity and specific targets for therapy. Removing excess and activated circulating leukocytes with adsorptive cytapheresis has been shown to be a potentially effective treatment for patients with an inflamed bowel. Adsorptive cytapheresis is a non-pharmacological approach for active IBD, in which known sources of inflammatory cytokines such as activated myeloid lineage leucocytes are selectively depleted from the circulatory system...
April 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28427109/traveler-s-diarrhea-vision-abnormalities-and-unsteady-gait-in-a-young-woman
#2
Tobias Mühling, Felix Gundling, Thomas Helmberger, Wolfgang Schepp
We report on the course of disease in a young woman, originally admitted with suspected refractory infectious tropical traveler's diarrhea. However, symptoms did not resolve upon either symptomatic or subsequent antibiotic therapy. When neurologic deterioration was observed, imaging studies revealed a dramatic series of thromboembolic events, including intracranial hemorrhage caused by extensive sinus vein thrombosis as well as thrombi of the right cardiac ventricle. Colonic mucosal biopsy samples finally led to the histologic diagnosis of ulcerative colitis...
April 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28418301/severe-mrsa-enterocolitis-caused-by-a-strain-harboring-enterotoxins-d-g-and-i
#3
Marco Bergevin, Alain Marion, David Farber, George R Golding, Simon Lévesque
We describe a case of methicillin-resistant Staphylococcus aureus (MRSA) enterocolitis in a healthy adult with previous antibiotic exposure. Colonoscopy revealed diffuse colitis and mild ileitis without ulceration. Stool cultures demonstrated abundant growth of MRSA and absent normal flora. Oral vancomycin treatment was effective and seems to be the consensus choice for therapy.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28417435/lachnospiraceae-shift-in-the-microbial-community-of-mice-faecal-sample-effects-on-water-immersion-restraint-stress
#4
Shiyin Li, Zelin Wang, Yun Yang, Sha Yang, Chenchen Yao, Kaiyun Liu, Sixin Cui, Quanming Zou, Hongwu Sun, Gang Guo
Stress, including both psychological and physical stimulation, can cause changes in the microbiota and mucosal function of the gastrointestinal system. There are few research studies available about the faecal microbiota changes after stress, such as water immersion restraint stress (WIRS). Therefore, in this study, we focused on analysing the composition changes of faecal microbiota in WIRS mice. The WIRS model, in which Blab/c mice were immersed in 21 ± 2 °C water for 4 h each day for 14 days, was established...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28402995/etiopathogenesis-of-inflammatory-bowel-disease-today-and-tomorrow
#5
Heitor S P de Souza
PURPOSE OF REVIEW: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD. RECENT FINDINGS: Here, we attempt to highlight novel environmental triggers, data on the gut microbiota, its interaction with the host, and the potential influence of diet and food components...
April 11, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28402994/intestinal-fibrosis-ready-to-be-reversed
#6
Giovanni Latella, Florian Rieder
PURPOSE OF REVIEW: Intestinal fibrosis is a common complication of several enteropathies, with inflammatory bowel disease (IBD) being the major cause. Intestinal fibrosis affects both ulcerative colitis and Crohn's disease, and no specific antifibrotic therapy exists. This review highlights recent developments in this area. RECENT FINDINGS: The pathophysiology of intestinal stricture formation includes inflammation-dependent and inflammation-independent mechanisms...
April 11, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28383667/inactivation-of-jnk2-as-carcinogenic-factor-in-colitis-associated-and-sporadic-colorectal-carcinogenesis
#7
Wiebke Lessel, Andrew Silver, Doerthe Jechorek, Thomas Guenther, Friedrich Wilhelm Roehl, Thomas Kalinski, Albert Roessner, Angela Poehlmann-Nitsche
We recently reported that dysregulated c-Jun N-terminal kinases (JNK) activity causes defective cell cycle checkpoint control, inducing neoplastic transformation in a cellular ulcerative colitis (UC) model. In the quiescent chronic phase of UC, p-p54 JNK was down-regulated and p-p46 JNK was up-regulated. Both were up-regulated in the acute phase. Consequently, increased p21WAF1 and γ-H2AX, two JNK-regulated proteins, induced cell cycle arrest. Their down-regulation led to checkpoint override, causing increased proliferation and undetected DNA damage in quiescent chronic phase, all characteristics of tumorigenesis...
April 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28375885/management-of-inflammatory-bowel-disease-in-the-elderly-patient-challenges-and-opportunities
#8
Ashwin N Ananthakrishnan, Tamara Donaldson, Karen Lasch, Vijay Yajnik
The population of older patients with inflammatory bowel disease (IBD) continues to grow, partly reflecting the aging global population in general. The debilitating effects of IBD compound age-related decrements in health and functional capacity, and make the medical management of older patients with Crohn's disease and ulcerative colitis distinctly challenging to clinicians. Here, we review the recent literature describing the pharmacologic management of IBD in this population, with focus on the safety, tolerability, and efficacy of common treatment options, such as steroids, immunomodulators, tumor necrosis factor-α antagonists, and integrin antagonists; surgical interventions in older patients are also discussed...
March 27, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28352306/risk-of-cardiovascular-disease-in-inflammatory-bowel-disease
#9
Ping Wu, Fangyuan Jia, Bao Zhang, Peiying Zhang
Cardiovascular disease (CVD) can arise because of chronic inflammation and inflammatory bowel disease (IBD) is one such disease where the risk for CVD and eventual heart failure is increased considerably. The incidence of IBD, which refers to both ulcerative colitis and Crohn's disease, has been on the increase in several countries and is a potential risk factor for CVD. Although IBD can potentially cause venous thromboembolism, its significance in arterial stiffening, atherosclerosis, ischemic heart disease and myocardial infarction is only being realized now and it is currently under debate...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28345530/fecal-microbiota-transplantation-methods-of-treatment-of-recurrent-clostridium-difficile-infections-and-other-diseases
#10
Klaudia Juszczuk, Katarzyna Grudlewska, Agnieszka Mikucka, Eugenia Gospodarek
Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections. Currently, the treatment of C. difficile infections is the use of metronidazole or vancomycin. However, in some patients, recurrent infection difficult to treat occurs. Fecal microbiota transplantation (FMT) is a new method used to treat the recurrent CDI. FMT consists in the infusion of the fecal suspension from a healthy donor into the gastrointestinal tract of a patient with CDI to restore the natural intestinal microflora...
March 27, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28337639/the-impact-of-mangiferin-from-belamcanda-chinensis-on-experimental-colitis-in-rats
#11
Marta Szandruk, Anna Merwid-Ląd, Adam Szeląg
BACKGROUND: Inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)] constitutes an important clinical problem. The pathogenesis of IBD remains unclear. It is believed that immune dysfunction, inflammatory mediators and oxidative damage play crucial roles in development of IBD. The condition is clinically associated with symptoms ranging from mild to severe during relapses, depending on the affected segment of the gastrointestinal tract. Bloody diarrhea with mucus, abdominal pain, weight loss and anemia are initial symptoms of both CD and UC...
March 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28337239/disease-activity-quality-of-life-and-indirect-costs-of-ulcerative-colitis-in-poland
#12
Paweł Kawalec, Ewa Stawowczyk, Małgorzata Mossakowska, Andrzej Pilc
INTRODUCTION: Ulcerative colitis (UC) require expensive, lifelong treatment, which generates huge direct costs and has a significant impact on the quality of life, especially in the active state of the disease. AIM: To assess the indirect costs, health-related quality of life, and clinical characteristics of patients with UC in Poland. Additionally, we investigated the association between activity of UC and productivity loss of patients in a Polish setting. MATERIAL AND METHODS: A questionnaire survey was conducted using the Patient Simple Clinical Colitis Activity Index (P-SCCAI) to assess disease activity, as well as the modified Work Productivity and Activity Impairment Questionnaire to assess productivity loss...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28329471/first-report-of-mesalamine-5-aminosalicylic-acid-as-the-causative-agent-in-a-case-of-acute-generalized-exanthamous-pustulosis
#13
Erin Rocci, Kelly Park, Kelli Hutchens, Laura Winterfield
Acute generalized exanthamous pustulosis (AGEP)is a rare eruption of non-follicular sterile pustuleson a diffuse background of erythema and edema,commonly associated with fever and leukocytosis.Antibiotics are implicated in most cases; however,other drugs have been reported to cause AGEP. Wereport a case of a 73-year-old man with a historyof ulcerative colitis who presented with a diffusepustular rash, renal failure, elevated liver functiontests, and leukocytosis with neutrophilia. A week priorto admission, the patient was started on mesalamineto treat colitis...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327112/prognosis-of-ulcerative-colitis-colorectal-cancer-vs-sporadic-colorectal-cancer-propensity-score-matching-analysis
#14
Yoon Dae Han, Mahdi Hussain Al Bandar, Audrius Dulskas, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
BACKGROUND: Ulcerative colitis (UC) harbours a high risk of UC-associated colorectal cancer (UCCC), which is important cause of morbidity and mortality in patients with inflammatory bowel disease. Overall Survival (OS) of patients with UCCC has not been addressed well in the literature. Thus, we compared oncologic outcome of UCCC and sporadic colorectal cancer (SCC) using propensity score matching analysis. METHODS: Propensity score matching was performed for 36 patients, a 1:1 matching method stratified into 18 in UCCC and 18 patients in SCC...
March 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28296822/the-different-effects-of-vegfa121-and-vegfa165-on-regulating-angiogenesis-depend-on-phosphorylation-sites-of-vegfr2
#15
Wang Shiying, Sun Boyun, Yuan Jianye, Zhang Wanjun, Tao Ping, Lin Jiang, Hu Hongyi
The effects of VEGFA isoforms on the vascular permeability and structure are still unclear. In this study, we found that VEGFA121 and VEGFA165, 2 isoforms of VEGFA, exerted the opposing effects of antiangiogenesis and proangiogenesis on regulating vascular endothelia cells proliferation and tube formation. The 2 isoforms affected the protein expression of Ras-related protein 1-GTPase-activating protein 1 (Rap1GAP) and thrombospondin 1, 2 important signal molecules of Rap1GAP/thrombospondin 1 signal pathway in primary human umbilical vein endothelial cells by regulating 2 different phosphorylating sites of VEGFR2, Tyr(1175) and Tyr(1214)...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28293637/identification-of-candidate-genes-related-to-inflammatory-bowel-disease-using-minimum-redundancy-maximum-relevance-incremental-feature-selection-and-the-shortest-path-approach
#16
Fei Yuan, Yu-Hang Zhang, Xiang-Yin Kong, Yu-Dong Cai
Identification of disease genes is a hot topic in biomedicine and genomics. However, it is a challenging problem because of the complexity of diseases. Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora. It has been proven to be associated with the development of intestinal malignancies. Although the specific pathological characteristics and genetic background of IBD have been partially revealed, it is still an overdetermined disease and the blueprint of all genetic variants still needs to be improved...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28293082/anti-inflammatory-intestinal-activity-of-combretum-duarteanum-cambess-in-trinitrobenzene-sulfonic-acid-colitis-model
#17
Gedson Rodrigues de Morais Lima, Flavia Danniele Frota Machado, Larissa Lucena Périco, Felipe Meira de Faria, Anderson Luiz-Ferreira, Alba Regina Monteiro Souza Brito, Cláudia Helena Pellizzon, Clélia Akiko Hiruma-Lima, Josean Fechine Tavares, José Maria Barbosa Filho, Leônia Maria Batista
AIM: To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS: Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS: Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28288653/inflammatory-bowel-disease-following-anti-interleukin-1-treatment-in-systemic-juvenile-idiopathic-arthritis
#18
Boris Hügle, Fabian Speth, Johannes-Peter Haas
BACKGROUND: Inflammatory bowel disease can develop in the context of some rheumatic diseases in childhood, including juvenile idiopathic arthritis (JIA). Inflammatory bowel disease (IBD) is frequently associated with other immune-mediated diseases; however, systemic onset JIA (sJIA) has not previously been connected to IBD. Treatment of sJIA has significantly changed in recent years, possibly causing changes in inflammatory patterns. Therefore, data from the German Center for Pediatric and Adolescent Rheumtology from 2010 until 2015 were analyzed by retrospective chart review...
March 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28288099/nlrp12-attenuates-colon-inflammation-by-maintaining-colonic-microbial-diversity-and-promoting-protective-commensal-bacterial-growth
#19
Liang Chen, Justin E Wilson, Mark J Koenigsknecht, Wei-Chun Chou, Stephanie A Montgomery, Agnieszka D Truax, W June Brickey, Christopher D Packey, Nitsan Maharshak, Glenn K Matsushima, Scott E Plevy, Vincent B Young, R Balfour Sartor, Jenny P-Y Ting
Inflammatory bowel diseases involve the dynamic interaction of host genetics, the microbiome and inflammatory responses. Here we found lower expression of NLRP12 (which encodes a negative regulator of innate immunity) in human ulcerative colitis, by comparing monozygotic twins and other patient cohorts. In parallel, Nlrp12 deficiency in mice caused increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective gut commensal strains (of the family Lachnospiraceae) and a greater abundance of colitogenic strains (of the family Erysipelotrichaceae)...
May 2017: Nature Immunology
https://www.readbyqxmd.com/read/28279838/modulation-of-sphingosine-1-phosphate-in-inflammatory-bowel-disease
#20
REVIEW
Laurent Peyrin-Biroulet, Ronald Christopher, Dominic Behan, Cheryl Lassen
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve an inappropriate immune reaction in the digestive tract, causing a variety of disabling symptoms. The advent of monoclonal antibodies (anti-tumor necrosis factor, anti-integrin, anti-interleukin -23) has revolutionized IBD management. Nevertheless, these agents, with potential for immunogenicity, are associated with high rates of response loss and disease relapse over time. They are also associated with high production costs...
March 7, 2017: Autoimmunity Reviews
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