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https://www.readbyqxmd.com/read/28444987/platelet-count-spleen-length-and-platelet-count-to-spleen-length-ratio-for-the-diagnosis-of-oesophageal-varices-in-people-with-chronic-liver-disease-or-portal-vein-thrombosis
#1
REVIEW
Agostino Colli, Juan Cristóbal Gana, Jason Yap, Thomasin Adams-Webber, Natalie Rashkovan, Simon C Ling, Giovanni Casazza
BACKGROUND: Current guidelines recommend screening of people with oesophageal varices via oesophago-gastro-duodenoscopy at the time of diagnosis of hepatic cirrhosis. This requires that people repeatedly undergo unpleasant invasive procedures with their attendant risks, although half of these people have no identifiable oesophageal varices 10 years after the initial diagnosis of cirrhosis. Platelet count, spleen length, and platelet count-to-spleen length ratio are non-invasive tests proposed as triage tests for the diagnosis of oesophageal varices...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28441857/-clinical-exploratory-application-of-robotic-resection-of-tumor-in-segment-%C3%A2-a-report-for-7-cases
#2
Y Y Song, R Liu, G D Zhao, W B Tang, M G Hu, C G Li
Objective: To investigate the feasibility and security of robotic resection of tumor in segment Ⅷ primarily. Methods: The clinicopathologic data of 7 patients who underwent robotic resection of tumor in segment Ⅷ using daVinci robotic system in the Department of Hepato-pancreato-biliary Surgical Oncology, Chinese PLA General Hospital from June 2016 to December 2016 were retrospectively analyzed. The lesion size, the tumor malignance degree mean operation time, intraoperative blood loss and the rate of conversion to laparotomy, postoperative hospital stay, mobidity and motality of all the 7 patients were collected...
April 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28441830/-a-case-of-tricho-hepato-enteric-syndrome
#3
J J Chen, L P Shi
No abstract text is available yet for this article.
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28439422/anti-aging-effect-and-gene-expression-profiling-of-dung-beetle-glycosaminoglycan-in-aged-rats
#4
Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jae Sam Hwang, Yi-Sook Jung, Kun-Koo Park
BACKGROUND: This study aimed to evaluate the anti-aging effect of a newly prepared insect-derived compound, dung beetle glycosaminoglycan (GAG), given intraperitoneally to old SD rats as part of their diet for 1 month. Insect GAG administration was found to be related to a reduction in oxidative damage, hepato-cellular biomarker levels, protein carbonyl content, and malondialdehyde concentration. The anti-aging-related molecular genetic mechanisms of dung beetle GAG are not yet fully elucidated...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28428958/debromoaplysiatoxin-as-the-causative-agent-of-dermatitis-in-a-dog-after-exposure-to-freshwater-in-california
#5
Birgit Puschner, Adrienne C Bautista, Chris Wong
Contamination of recreational waters with cyanobacterial toxins continues to increase and presents a risk to animals and humans. Although cases of acute hepato- and neurotoxicoses in dogs following cyanotoxin exposure exist, no reports of skin-related reactions in dogs exist. A 5-year-old female spayed 34 kg Bracco Italiano was initially presented for rapid onset of severe pruritus and urticaria. Marked excoriation and erythema were noted over the chest and neck, while urticaria was noted in the inguinal regions and ventral abdomen...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28428136/hesperetin-derivative-14-alleviates-inflammation-by-activating-ppar-%C3%AE-in-mice-with-ccl4-induced-acute-liver-injury-and-lps-treated-raw264-7-cells
#6
Xin Chen, Hai-Wen Ding, Hai-Di Li, Hui-Min Huang, Xiao-Feng Li, Yang Yang, Yi-Long Zhang, Xue-Yin Pan, Cheng Huang, Xiao-Ming Meng, Jun Li
Hesperetin is a flavanone glycoside compound naturally occurring in the fruit peel of Citrusaurantium L. (Rutaceae). Previous studies revealed that hesperetin possesses various pharmacological effects, including anti-inflammation, anti-tumor, anti-oxidant and neuroprotective properties. Hesperetin derivative-14 (HD-14) is a derivative of hesperetin improved in water solubility and bioavailability. In this study, we indicated that HD-14 (2μM) significantly attenuated inflammation in LPS-treated RAW264.7 cells and had hepato-protective effects and anti-inflammatory effects (100mg/kg) on C57BL/6J mice with CCl4-induced acute liver injury...
April 17, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28413464/anti-climacterium-effects-of-pomegranate-concentrated-solutions-in-ovariectomized-ddy-mice
#7
Su Jin Kang, Beom Rak Choi, Seung Hee Kim, Hae Yeon Yi, Hye Rim Park, Chang Hyun Song, Sae Kwang Ku, Young Joon Lee
In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28405330/middle-term-mortality-and-re-bleeding-after-initial-diverticular-bleeding-a-nationwide-study-of-365-mostly-elderly-french-patients
#8
Diane Lorenzo, Claire Gallois, Pierre Lahmek, Bruno Lesgourgues, Christine Champion, Claire Charpignon, Roger Faroux, Bruno Bour, André-Jean Remy, Chantal Naouri, Magali Picon, Eric Poncin, Gilles Macaigne, Jacques-Arnaud Seyrig, David Bernardini, Guy Bellaïche, Denis Grasset, Jean Henrion, Frédéric Heluwaert, René Piperaud, Gilbert Bordes, Francois Bourhis, Jean-Pierre Arpurt, Alexandre Pariente, Stéphane Nahon
BACKGROUND AND AIMS: The aim of this study was to determine the mortality and re-bleeding rates, and the risk factors involved, in a cohort of patients with previous diverticular bleeding (DB). METHODS: In 2007, data on 2462 patients with lower gastrointestinal (GI) bleeding were collected prospectively at several French hospitals. We studied the follow-up of patients with DB retrospectively. The following data were collected: age, mortality rates and re-bleeding rates, drug intake, surgery and comorbidities...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28404076/perioperative-analgesia-in-hepato-pancreato-biliary-surgery
#9
Stephen J Wigmore
No abstract text is available yet for this article.
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28404067/continuous-wound-infiltration-versus-epidural-analgesia-after-hepato-pancreato-biliary-surgery-pop-up-a-randomised-controlled-open-label-non-inferiority-trial
#10
Timothy H Mungroop, Denise P Veelo, Olivier R Busch, Susan van Dieren, Thomas M van Gulik, Tom M Karsten, Steve M de Castro, Marc B Godfried, Bram Thiel, Markus W Hollmann, Philipp Lirk, Marc G Besselink
BACKGROUND: Epidural analgesia is the international standard for pain treatment in abdominal surgery. Although some studies have advocated continuous wound infiltration with local anaesthetics, robust evidence is lacking, especially on patient-reported outcome measures. We aimed to determine the effectiveness of continuous wound infiltration in hepato-pancreato-biliary surgery. METHODS: In this randomised controlled, open label, non-inferiority trial (POP-UP), we enrolled adult patients undergoing hepato-pancreato-biliary surgery by subcostal or midline laparotomy in two Dutch hospitals...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403899/hepato-bronchial-fistula-secondary-to-perforated-sigmoid-diverticulitis-a-case-report
#11
Jun Sunny Yin, Shaylan Govind, Daniele Wiseman, Richard Inculet, Raymond Kao
BACKGROUND: Patients with diverticulitis are predisposed to hepatic abscesses via seeding through the portal circulation. Hepatic abscesses are well-documented sequelae of diverticulitis, however instances of progression to hepato-bronchial fistulization are rare. We present a case of diverticulitis associated with hepatic abscess leading to hepato-bronchial fistulization, which represents a novel disease course not yet reported in the literature. CASE PRESENTATION: A 61-year-old Caucasian man presented with a history of unintentional weight loss and dyspnea both at rest and with exertion...
April 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28395956/benefit-of-an-implanted-solid-barrier-for-the-feasibility-of-a-sequence-of-three-different-hepato-biliary-operations-in-a-small-animal-model
#12
B Richter, C Sänger, F Mussbach, H Scheuerlein, U Settmacher, U Dahmen
BACKGROUND: Current liver surgery includes complex multi-stage procedures such as portal vein ligation (PVL) followed by extended liver resection, especially in patients with Klatskin tumours. The risk for severe adhesions increases with every procedure. Finally, this complex sequence could fail because of malignant adhesions. Therefore, we proved the hypothesis of reducing malignant adhesions and increasing feasibility of a sequence with three hepato-biliary operations by implantation of a solid barrier...
April 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28391553/effect-of-a-bradykinin-potentiating-factor-isolated-from-scorpion-venom-leiurus-quinquestriatus-on-some-blood-indices-and-lipid-profile-in-irradiated-rats
#13
Muhammad M A Salman, Ahmed M Kotb, Mohie A M Haridy, Klaus Golka, Seddik Hammad
Bradykinin appears to be an important regulator of cardiovascular function. It is also being increasingly noted as a participant in actions of drugs that affect the liver, kidney, and circulation. In our previous studies, bradykinin-potentiating factor (BPF) isolated from scorpion venom (Leiurus quinquestriatus) has been shown to be protective against hepato- and nephrotoxicity as well as healing skin burns by reducing oxidative stress in hyperglycemic conditions. Therefore, we aim to evaluate the ability of BPF in treating irradiated rats...
April 8, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28381385/hida-scan-for-functional-gallbladder-disorder-ensure-that-you-know-how-the-scan-was-done
#14
Naeem Goussous, Hadia Maqsood, Ethan Spiegler, Gopal C Kowdley, Steven C Cunningham
BACKGROUND: Despite the increasing use of fatty meal (FM) as a substitute for cholecystokinin (CCK) in pain reproduction during hepato-imino-diacetic acid (HIDA) scan in functional gallbladder disorder, there are no studies comparing the differences between CCK and FM. The present study was to compare the efficacy of FM in comparison of CCK in FGBD application. METHODS: Patients undergoing HIDA scans from August 2013 to May 2014 were divided into two groups: those undergoing CCK-stimulated HIDA scan versus FM-stimulated HIDA scan...
April 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28379594/pyrrolizidine-alkaloids-enhance-alcohol-induced-hepatocytotoxicity-in-vitro-in-normal-human-hepatocytes
#15
M G Neuman, L B Cohen, V Steenkamp
OBJECTIVE: Herbal remedies containing pyrrilidozine alkaloids (PA)s can induce liver damage, including hepato-sinusoidal obstruction syndrome (HSOS) or veno-occlusive liver disease (VOD). Some individuals misusing alcohol consume also teas and/or herbal remedies containing PA. The interaction or additive toxicity of alcohol to PA toxicity needs to be addressed. The objectives of this study are 1) to review the scientific literature on the PA-induced liver toxicity; 2) identify possible mechanism(s) involved in PA-induced hepatocytotoxicity in the presence or absence of ethanol (EtOH) in vitro in normal human hepatocytes (NHH) in primary culture...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28376418/a-case-report-of-bloody-pancreatitis
#16
Lemuel Pran, Reena Moonsie, James Byam, Shivraj BahadurSingh, Gurubasavaiah Manjunath, Marlon Seenath, Shanta Baijoo
INTRODUCTION: Haemobilia is an uncommon entity even though its frequency has increased with hepato-biliary instrumentation and procedures. It can be associated with obstructive jaundice and pancreatitis (Green et al., 2001) [1]. Haemobilia following cholecystectomy has frequently been reported in association with hepatic artery pseudo-aneurysm (Curet et al., 1981; Ribeiro et al., 1998) [2,3]. The authors wish to report a case of haemobilia due to a porto-biliary fistula presenting as acute pancreatitis...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28371248/randomized-controlled-trial-of-perioperative-antimicrobial-therapy-based-on-the-results-of-preoperative-bile-cultures-in-patients-undergoing-biliary-reconstruction
#17
Kunishige Okamura, Kimitaka Tanaka, Takumi Miura, Yoshitsugu Nakanishi, Takehiro Noji, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: The high frequency of surgical site infections (SSIs) after hepato-pancreato-biliary (HPB) surgery is a problem that needs to be addressed. This prospective, randomized, controlled study examined whether perioperative prophylactic use of antibiotics based on preoperative bile culture results in HPB surgery could decrease SSI. METHODS: Participants comprised 126 patients who underwent HPB (bile duct, gallbladder, ampullary, or pancreatic) cancer surgery with biliary reconstruction at Hokkaido University Hospital between August 2008 and March 2013 (UMIN Clinical Trial Registry #00001278)...
March 29, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28361247/the-potential-curative-effect-of-rebamipide-in-hepatic-ischemia-reperfusion-injury
#18
Abdallah M Gendy, Dalaal M Abdallah, Hanan S El-Abhar
Rebamipide (Reba), a gastroprotective drug, has signified its hepatoprotective activity; however, its possible post-therapeutic intervention in hepatic ischemia/reperfusion (I/R) remains elusive. Consequently, the intent of this study was to test Reba modulatory effect on nuclear factor (NF)-κB signaling in hepatic I/R model. Rats were randomized into sham, I/R, Reba 60, and Reba100 (60 and 100 mg/kg, respectively) groups. Ischemia was induced for 30 min followed by 3-day reperfusion to set up a model of partial (70%) warm hepatic ischemia...
March 30, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28352230/lead-induced-hepato-renal-damage-in-male-albino-rats-and-effects-of-activated-charcoal
#19
Samuel J Offor, Herbert O C Mbagwu, Orish E Orisakwe
Lead is a multi-organ toxicant implicated in various cancers, diseases of the hepatic, renal, and reproductive systems etc. In search of cheap and readily available antidote this study has investigated the role of activated charcoal in chronic lead exposure in albino rats. Eighteen mature male albino rats were used, divided into three groups of six rats per group. Group 1 (control rats) received deionised water (10 ml/kg), group 2 was given lead acetate solution 60 mg/kg and group 3 rats were given lead acetate (60 mg/kg) followed by Activated charcoal, AC (1000 mg/kg) by oral gavage daily for 28 days...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28344684/splenic-vein-thrombosis-as-a-rare-complication-of-disseminated-tuberculosis-imaging-diagnosis-and-case-report
#20
Satarupa Roy, Shuchi Bhatt, Rajesh Rawal, Anupama Tandon, Neha Meena
BACKGROUND: Venous thromboembolism is a known but rare complication associated with Mycobacterium tuberculosis infection. The reported incidence of venous thromboembolism is 1.5-3.4% of infected patients, and it occurs due to a hypercoagulable state induced by the associated inflammation. CASE REPORT: A young woman with pulmonary tuberculosis was found to have disseminated tuberculosis and a clinically unsuspected partial thrombus in the splenic vein on imaging...
2017: Polish Journal of Radiology
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