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https://www.readbyqxmd.com/read/29433420/liver-proteome-response-of-pre-harvest-atlantic-salmon-following-exposure-to-elevated-temperature
#1
Waldo G Nuez-Ortín, Chris G Carter, Peter D Nichols, Ira R Cooke, Richard Wilson
BACKGROUND: Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in thermal adaptation. With the aim of identifying mechanisms underlying liver plasticity in response to chronic elevated temperature in Atlantic salmon, label-free shotgun proteomics was used to explore quantitative protein changes after 43 days of exposure to elevated temperature...
February 12, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29425642/effect-of-dioscin-on-promoting-liver-regeneration-via-activating-notch1-jagged1-signal-pathway
#2
Lina Xu, Lina Gu, Xufeng Tao, Youwei Xu, Yan Qi, Lianhong Yin, Xu Han, Jinyong Peng
BACKGROUND: Development of novel candidates to promote liver regeneration is critical important after partial hepatectomy (PH). Dioscin, a natural product, shows potent effect on liver protection in our previous works. PURPOSE: This work aimed to investigate the effect and underlying mechanisms of dioscin on liver regeneration. METHODS: The promoting proliferation effects of dioscin on mouse hepatocytem AML12 cells, rat primary hepatocytes, rats and mice after 70% PH were evaluated...
January 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29414242/hepato-protective-influence-of-quercetin-and-ellagic-acid-on-thioacetamide-induced-hepatotoxicity-in-rats
#3
Nehal Aly Afifi, Marwa Ibrahim, Mona Galal
Despite all the studies performed up to now, therapy choices for liver injuries are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries remains a challenge. The Quercetin (QR) and ellagic acid (EA) had a potent antioxidant and anti-inflammatory activities. The current study aimed at evaluating the potential hepatoprotective influence of QR and EA against thioacetamide (TAA)-induced liver toxicity in rats and the underlying mechanism using silymarin as a reference drug...
February 7, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29412802/high-fat-diet-stimulates-the-gut-pathogenic-microbiota-and-maintains-hepatic-injury-in-antibiotic-treated-rats
#4
Sooad Al-Daihan, Abir Ben Bacha, Abeer M Al-Dbass, Mona Awad Alonazi, Ramesa Shafi Bhat
The gut and the liver are closely linked to each other, as changes in the gut microbiota can play a significant role in the development of many liver diseases. Gut bacteria respond rapidly to changes in diet and thus can affect the liver through their metabolites. The impact of a high lipid diet on the liver in the presence of an altered gut flora modulated by ampicillin was investigated. The study was performed on 30 male Western albino rats randomly divided into 3 groups: control (phosphate buffered saline treated), group II (ampicillin 50 mg/kg for three weeks to induce microbiota alterations and fed on standard diet) and group III (same dose of ampicillin and fed on a lipid rich diet)...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29412449/use-of-aspirin-and-bleeding-related-complications-after-hepatic-resection
#5
M Gelli, M A Allard, O Farges, C Paugam-Burtz, J Y Mabrut, J M Regimbeau, E Vibert, E Boleslawski
BACKGROUND: The operative risk of hepatectomy under antiplatelet therapy is unknown. This study sought to assess the outcomes of elective hepatectomy performed with or without aspirin continuation in a well balanced matched cohort. METHODS: Data were retrieved from a multicentre prospective observational study. Aspirin and control groups were compared by non-standardized methods and by propensity score (PS) matching analysis. The main outcome was severe (Dindo-Clavien grade IIIa or more) haemorrhage...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29407817/interactive-effects-of-chronic-dietary-selenomethionine-and-cadmium-exposure-in-rainbow-trout-oncorhynchus-mykiss-a-preliminary-study
#6
Ankur Jamwal, Danielle Lemire, Melissa Driessnack, Mohammad Naderi, Som Niyogi
The present study investigated the interactive effects of dietary cadmium (Cd) and selenium (Se) on the tissue-specific (liver, kidney, and muscle) accumulation of these two elements, hepatic oxidative stress response, and morphometrics in rainbow trout (Oncorhynchus mykiss) during chronic exposure. Fish were exposed to elevated dietary Cd (45 μg g-1 dry wt.), and medium (10 μg g-1 dry wt.) or high (45 μg g-1 dry wt.) dietary selenium (added as selenomethionine), both alone and in combination, for 30 days...
February 1, 2018: Chemosphere
https://www.readbyqxmd.com/read/29402925/metabolic-hydrolysis-of-aromatic-amides-in-selected-rat-minipig-and-human-in-vitro-systems
#7
Peter R Bradshaw, Ian D Wilson, Rachel Upcott Gill, Philip J Butler, Clive Dilworth, Toby J Athersuch
The release of aromatic amines from drugs and other xenobiotics resulting from the hydrolysis of metabolically labile amide bonds presents a safety risk through several mechanisms, including geno-, hepato- and nephrotoxicity. Whilst multiple in vitro systems used for studying metabolic stability display serine hydrolase activity, responsible for the hydrolysis of amide bonds, they vary in their efficiency and selectivity. Using a range of amide-containing probe compounds (0.5-10 µM), we have investigated the hydrolytic activity of several rat, minipig and human-derived in vitro systems - including Supersomes, microsomes, S9 fractions and hepatocytes - with respect to their previously observed human in vivo metabolism...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29397533/estrogen-receptors-are-involved-in-the-neuroprotective-effect-of-silibinin-in-a%C3%AE-1-42-treated-rats
#8
Xiaoyu Song, Bo Liu, Lingyu Cui, Biao Zhou, Lu Liu, Weiwei Liu, Guodong Yao, Mingyu Xia, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Shin-Ichi Tashiro, Takashi Ikejima
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a cascade of pathologic changes. A widely discussed theory indicates that amyloid β (Aβ) peptides are the causative agents of AD. Silibinin, a flavonoid derived from milk thistle, is well known for its hepato-protective activities and we have reported the neuroprotective effects of silibinin. In this study, we investigated the role of estrogen receptors (ERs) in silibinin's neuroprotective effect on Aβ1-42-injected rats...
February 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29394621/-a-case-report-of-laparoscopy-assisted-distal-gastrectomy-for-gastric-cancer-with-an-adachi-type-vi-anomaly-group-27-institution
#9
Motohiro Chuman, Shinichi Sakuramoto, Takuya Oba, Kenichi Aratani, Masato Kasuya, Mitsuo Wakata, Michitaka Ogura, Yutaka Miyawaki, Hisashi Gunji, Hiroshi Sato, Kojun Okamoto, Shigeki Yamaguchi, Isamu Koyama
We report the case of a 79-year-old man, with gastric cancer detected on upper gastrointestinal endoscopic examination performed by a nearby medical clinic, and referred to our hospital, in April 201X. He was diagnosed with gastric cancer(ML, less, 0- II a+ II c, tub 1-2, cT1bN0M0, cStage I A). We performed laparoscopy assisted distal gastrectomy, D1+lymph node dissection, and Billroth I (B- I )reconstruction. Abdominal CT scan before surgery confirmed vascular anomaly of the celiac artery. We diagnosed Adachi type VI, preserved hepato-gastric artery trunk, and performed D1 plus dissection plus B- I reconstruction with small incision in the epigastrium...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394240/beneficial-effects-of-adrenal-androgen-supplement-in-bleeding-cirrhotic-rats
#10
Hui-Chun Huang, Shao-Jung Hsu, Ching-Chih Chang, Ming-Hung Tsai, Fa-Yauh Lee, Ming-Chih Hou, Shou-Dong Lee
Critical illness is accompanied by hypothalamic-pituitary-adrenal axis activation, but adrenal insufficiency characterized by inadequate glucocorticoid synthesis is common in critically ill cirrhotic patients, the 'hepato-adrenal syndrome'. Adrenal cortex also synthesizes androgen (dehydroepiandrosterone, DHEA). DHEA maintains microcirculation by enhancing vascular endothelial nitric oxide synthase (eNOS) activity. In critical patients of other disease entities, a shift of adrenal steroidogenesis away from androgens towards glucocorticoid has been noted, arousing interests in androgen replacement in critical settings...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29390925/diagnostic-criteria-and-contributors-to-gilbert-s-syndrome
#11
Karl-Heinz Wagner, Ryan G Shiels, Claudia Anna Lang, Nazlisadat Seyed Khoei, Andrew C Bulmer
Hyperbilirubinemia is a well-known condition in the clinical setting; however, the causes of elevated serum bilirubin are diverse, as are the clinical ramifications of this condition. For example, diagnoses of individuals vary depending on whether they exhibit an unconjugated or conjugated hyperbilirubinemia. Diagnoses can include conditions of disordered bilirubin metabolism (Gilbert's, Crigler-Najjar, Rotor, or Dubin-Johnson syndromes) or an acquired disease, including alcoholic/non-alcoholic fatty liver disease, hepatotropic hepatitis, cirrhosis, or hepato-biliary malignancy...
February 1, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29390349/sj%C3%A3-gren-s-syndrome-manifesting-as-clinicopathological-features-of-tafro-syndrome-a-case-report
#12
Shino Fujimoto, Hiroshi Kawabata, Nozomu Kurose, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yoshimasa Fujita, Toshihiro Fukushima, Yasufumi Masaki
RATIONALE: TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe TAFRO syndrome-like systemic symptoms during the clinical course of juvenile-onset Sjögren's syndrome in a 32-year-old woman. PATIENT CONCERNS: The patient was admitted due to dyspnea, fever, polyarthralgia, and generalized edema. She had been diagnosed with Sjögren's syndrome at the age of 14 years, based on histopathological examination of a biopsy of the minor salivary glands and the development of Raynaud's phenomenon, with no follow-up treatment required...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29386766/teratoma-arising-from-hepato-duodenal-ligament-in-the-newborn-with-transection-of-portal-vein-hepatic-artery-and-common-bile-duct-a-surgical-challenge
#13
V R Ravikumar, G Rajamani, Vijayakumar Raju, Rajani Sundar, Sowmya Ravikumar, Raghul Maniam
A 7-day-old neonate presented with a large intra-abdominal mass adherent to the hilum of the liver encasing the portal triad. During excision, the portal vein, hepatic artery, and common bile duct were injured. The repair was done promptly and needed massive blood transfusion. Histopathology revealed immature teratoma Grade III. Survival in neonate following total transection of portal triad is rare and has not been reported.
January 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29386155/therapeutic-effect-of-alkaloids-and-glycosides-of-colocynth-seeds-on-liver-injury-associated-with-metabolic-syndrome-in-wistar-rats-subject-to-nutritional-stress
#14
Khadidja Tabani, Zahia Birem, Hanane Halzoune, Wassila Saiah, Farid Lahfa, Elhadj Ahmed Koceir, Naima Omari
The Citrullus colocynthis, commonly called colocynth, is known because of its purgative effects and whose seeds are commonly used as certain diseases treatment, namely liver diseases, in the Mediterranean countries traditional medicine. This study aims to analyze the effect of two colocynth extracts « glycosides » and « alkaloids » on metabolic and histological disorders associated with liver function in Wistar rats (Rattus norvegicus). This pathology is due to an enriched oil palm diet. For this purpose, Wistar male rats n = 18, weighing between 130g and 150g, are divided into two lots...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29383842/a-new-mutation-in-the-c-terminal-end-of-ttc37-leading-to-a-mild-form-of-syndromic-diarrhea-tricho-hepato-enteric-syndrome-in-seven-patients-from-two-families
#15
Alexandre Fabre, Laetitia-Marie Petit, Lars F Hansen, Anne V Wewer, Clothilde Esteve, Charlène Chaix, Patrice Bourgeois, Catherine Badens, Anders Paerregaard
Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare congenital enteropathy with seven main clinical features: intractable diarrhea of infancy, hair abnormalities, intrauterine growth restriction (IUGR), facial dysmorphism, immune dysfunction, and liver and skin abnormalities. SD/THE is caused by mutations in TTC37 or SKIV2L, two genes encoding components of the human SKI complex. To date, approximately 50 SD/THE patients have been described with a wide spectrum of mutations, and only one recurrent mutation has been identified in independent families...
January 31, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29376426/-systemic-mastocytosis-with-progressive-disease-course
#16
Judit Várkonyi, Gergely Szombath, Anna Vályi-Nagy, Judit Csomor, Krisztina Egedi, Ilona Kovalszky, Katalin Tölgyesi, László Szerafin, László Tóth, Györgyi Soós, Tamás Masszi
Authors report on a case of a male patient of systemic mastocytosis that was associated with extensive cutaneous lesions. Chronic diarrhoea worsening his quality of life was well managed by the administration of antihistamines. The pleural fluid recurrence soon after drainage has been controlled by the administration of alpha interferon. 40 years after the onset of the first skin signs progression has been manifested in the development of "B" (bone marrow infiltration rate >30%, dysmyelopoiesis, serum tryptase >20 μg/L, hepato- and splenomegaly) and "C" symptoms (liver function test abnormalities, cytopenia, malabsorption, osteoporosis)...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29366679/the-combination-of-an-hdac6-inhibitor-and-a-somatostatin-receptor-agonist-synergistically-reduces-hepato-renal-cystogenesis-in-an-animal-model-of-polycystic-liver-disease
#17
Maria Lorenzo Pisarello, Tatyana V Masyuk, Sergio A Gradilone, Anatoliy I Masyuk, Jingyi Francess Ding, Pui-Yuen Lee, Nicholas F LaRusso
Hepatic cystogenesis in polycystic liver disease (PLD) is associated with abnormalities in multiple cellular processes, including elevated cAMP and over-expression of histone deacetylase 6 (HDAC6). Disease progression in PCK rats (an animal model of PLD) is attenuated by inhibition of either cAMP production or HDAC6. Therefore, we hypothesized that concurrent targeting of HDAC6 and cAMP would synergistically reduce cyst growth. Changes in hepato-renal cystogenesis were examined in PCK rats treated with: i) a pan-HDAC inhibitor, panobinostat; ii) three specific HDAC6 inhibitors, ACY-1215, ACY-738, and ACY-241; and iii) a combination of ACY-1215 and the somatostatin receptor analog, pasireotide...
January 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29361652/proposed-diagnostic-criteria-for-acute-on-chronic-liver-failure-in-japan
#18
Satoshi Mochida, Nobuaki Nakayama, Akio Ido, Kazuaki Inoue, Takuya Genda, Yasuhiro Takikawa, Isao Sakaida, Shuji Terai, Osamu Yokosuka, Masahito Shimizu, Hajime Takikawa
To establish diagnostic criteria for acute-on-chronic liver failure (ACLF) in Japan, the Intractable Hepato-Biliary Disease Study Group of Japan performed a multicenter pilot survey for patients fulfilling the APASL, EASL-Clif Consortium, or Chinese Medical Association (CMA) diagnostic criteria for ACLF and found that the APASL criteria were suitable for screening Japanese patients with ACLF when patients whose conditions were triggered by gastrointestinal bleeding were included within the disease entity, while the EASL-Clif Consortium criteria were useful for classifying the severity of the patients' conditions...
January 23, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29359013/molecular-basis-of-hepatocellular-carcinoma-induced-by-hepatitis-c-virus-infection
#19
REVIEW
Mohammad Irshad, Priyanka Gupta, Khushboo Irshad
Present study outlines a comprehensive view of published information about the underlying mechanisms operational for progression of chronic hepatitis C virus (HCV) infection to development of hepatocellular carcinoma (HCC). These reports are based on the results of animal experiments and human based studies. Although, the exact delineated mechanism is not yet established, there are evidences available to emphasize the involvement of HCV induced chronic inflammation, oxidative stress, insulin resistance, endoplasmic reticulum stress, hepato steatosis and liver fibrosis in the progression of HCV chronic disease to HCC...
December 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29351922/activation-of-constitutive-androstane-receptor-ameliorates-renal-ischemia-reperfusion-induced-liver-and-kidney-injury
#20
You-Jin Choi, Dong Zhou, Anne Barbosa, Yongdong Niu, Xiudong Guan, Meishu Xu, Songrong Ren, Thomas Nolin, Yiuhua Liu, Wen Xie
Acute kidney injury (AKI) is associate with high mortality. Despite the evidence of AKI-induced distant organ injury, a relationship between AKI and liver injury has not been clearly established. The goal of this study is to investigate whether renal ischemia-reperfusion (IR) can affect liver pathophysiology. We showed that renal IR in mice induced fatty liver and compromised liver function through the down-regulation of constitutive androstane receptor (CAR; -90.4%) and inhibition of hepatic very low-density lipoprotein-triglyceride (VLDL-TG) secretion (-28...
January 19, 2018: Molecular Pharmacology
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