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https://www.readbyqxmd.com/read/29663826/antioxidant-and-hepato-preventive-effect-of-citrus-aurantium-extract-against-carbon-tetrachloride-induced-hepatotoxicity-in-rats-and-characterisation-of-its-bioactive-compounds-by-hplc-ms
#1
Anis Ben Hsouna, Manel Gargouri, Wissal Dhifi, Walid Saibi
The objective of this study is to explore the preventive effects of ethyl acetate fraction from Citrus aurantium leaf extract (EACA), associated with its phytochemical content, against the toxic impacts of acute exposure to carbon tetrachloride (CCl4 ) in the liver of adult rats. HPLC analysis of ethyl acetate fraction from extract C. aurantium revealed eight compounds. Administration of a single dose of CCl4 caused hepatoxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances) and in protein carbonyl level but a decrease in antioxidant markers in the liver tissue...
April 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29657389/hepato-nephropathology-associated-with-inclusion-body-hepatitis-complicated-with-citrinin-mycotoxicosis-in-a-broiler-farm
#2
Asok Kumar Mariappan, Palanivelu Munusamy, Shyma K Latheef, Shambu Dayal Singh, Kuldeep Dhama
Aim: Mortality in a broiler chicken farm was investigated for identifying the cause of mortality. Materials and Methods: A broiler farm with a population of 16000 succumbed to a disease outbreak. Clinical signs, vaccination history and mortality, were recorded. Necropsy examination and microscopic examination were carried out along with toxicological and molecular studies. Results: The clinical signs in the affected broiler birds were of non-specific nature with a total mortality of 26...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29649635/co-delivery-of-docetaxel-and-gemcitabine-by-anacardic-acid-modified-self-assembled-albumin-nanoparticles-for-effective-breast-cancer-management
#3
Varun Kushwah, Sameer S Katiyar, Chander Parkash Dora, Ashish Kumar Agrawal, Dimitrios A Lamprou, Ramesh C Gupta, Sanyog Jain
In the present study, we have modified bovine serum albumin (BSA) by covalently conjugating with anacardic acid (AA) and gemcitabine (GEM) and further used for development of docetaxel (DTX) loaded nanoparticles (AA-GEM-BSA NPs). AA is supposed to provide tumor targeting through VEGF receptors overexpressed in tumors, while the combination of GEM and DTX is supposed to provide synergistic activity by targeting multiple pathways. The conjugate was synthesized via carbodiimide chemistry and characterized by 1 H NMR, FTIR, MALDI-TOF and elemental analysis...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29644111/a-rare-combined-variation-of-the-coeliac-trunk-renal-and-testicular-vasculature
#4
Renate Elke Potgieter, Adam Michael Taylor, Quenton Wessels
The authors report a rare variation of the coeliac trunk, renal and testicular vasculature in a 27-year-old male cadaver. In the present case, the coeliac trunk and superior mesenteric artery was replaced by a modified coeliacomesenteric trunk formed by hepato-gastric and superior mesenteric arteries. Here the hepato-gastric artery or trunk contributed towards the total hepatic inflow as well as a gastro-duodenal artery. A separate right gastric artery and an additional superior pancreatico-duodenal artery was also found in addition with a retro-aortic left renal vein and a bilateral double renal arterial supply...
March 2018: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#5
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29628007/the-new-national-registry-for-gastrointestinal-surgery-in-norway-norgast
#6
K Lassen, L S Nymo, H Kørner, K Thon, T Grindstein, H H Wasmuth, T Moger, B A Bjørnbeth, S Norderval, M T Eriksen, A Viste
BACKGROUND AND AIMS: There is an increasing demand for high-quality data for the outcome of health care. Diseases of the gastro-intestinal tract involve large patient groups often presenting with serious or life-threatening conditions. Complications may affect treatment outcomes and lead to increased mortality or reduced quality of life. A continuous, risk-adjusted monitoring of major complications is important to improve the quality of health care to patients undergoing gastrointestinal resections...
April 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29624208/gemcitabine-based-chemotherapy-for-advanced-biliary-tract-carcinomas
#7
REVIEW
Omar Abdel-Rahman, Zeinab Elsayed, Hesham Elhalawani
BACKGROUND: Biliary tract cancers are a group of rare heterogeneous malignant tumours. They include intrahepatic and extrahepatic cholangiocarcinomas, gallbladder carcinomas, and ampullary carcinomas. Surgery remains the optimal modality of therapy leading to long-term survival for people diagnosed with resectable biliary tract carcinomas. Unfortunately, most people with biliary tract carcinomas are diagnosed with either unresectable locally-advanced or metastatic disease, and they are only suitable for palliative chemotherapy or supportive care...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29620455/pancreatitis-is-an-important-feature-of-broilers-suffering-from-inclusion-body-hepatitis-leading-to-dysmetabolic-conditions-with-consequences-for-zootechnical-performance
#8
Miguel Matos, Károly Dublecz, Beatrice Grafl, Dieter Liebhart, Michael Hess
The aim of the present study was to further unravel the pathophysiologic mechanisms of inclusion body hepatitis (IBH). In a first trial, the susceptibility of specific-pathogen-free (SPF) broilers to fowl aviadenovirus (FAdV) infections was investigated. Regardless of viral dose, route of infection, and susceptibility to disease on day 1, the 3-week-old SPF broilers showed resistance to IBH, with no mortality being recorded throughout the experiment. In a second trial, SPF broilers were orally infected at 3 weeks of age with a FAdV-E strain, and their digestive and metabolic processes were monitored...
March 2018: Avian Diseases
https://www.readbyqxmd.com/read/29616107/awareness-of-hepatic-arterial-variants-is-required-in-surgical-oncology-decision-making-strategy-case-report-and-review-of-literature
#9
Robert Sitarz, Monika Berbecka, Jerzy Mielko, Karol Rawicz-Pruszyński, Grzegorz Staśkiewicz, Ryszard Maciejewski, Wojciech Polkowski
Surgery for the treatment of pancreatic cancer remains the gold standard, however, the identification of the vascular supply of the pancreas and the nearby organs remains a crucial difficulties in a curative resection. During pancreatic head resection for carcinoma dissection of regional arterial vasculature is mandatory. Normal coeliac and hepatic arterial anatomy occurs in ~50-70% of patients and multiple variations have been described. Knowledge of multiple arterial anomalies is essential in hepato-pancreatico-billary surgery to avoid unnecessary complications...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29614044/toxic-cyanobacteria-in-svalbard-chemical-diversity-of-microcystins-detected-using-a-liquid-chromatography-mass-spectrometry-precursor-ion-screening-method
#10
Julia Kleinteich, Jonathan Puddick, Susanna A Wood, Falk Hildebrand, H Dail Laughinghouse Iv, David A Pearce, Daniel R Dietrich, Annick Wilmotte
Cyanobacteria synthesize a large variety of secondary metabolites including toxins. Microcystins (MCs) with hepato- and neurotoxic potential are well studied in bloom-forming planktonic species of temperate and tropical regions. Cyanobacterial biofilms thriving in the polar regions have recently emerged as a rich source for cyanobacterial secondary metabolites including previously undescribed congeners of microcystin. However, detection and detailed identification of these compounds is difficult due to unusual sample matrices and structural congeners produced...
April 3, 2018: Toxins
https://www.readbyqxmd.com/read/29600900/bilirubin-acts-as-a-multi-potent-guardian-of-cardiovascular-integrity-more-than-just-a-radical-idea
#11
Andrew Cameron Bulmer, Bhavisha A Bakrania, Eugene Francois Du Toit, Ai-Ching Boon, Paul J Clark, Lawrie W Powell, Karl-Heinz Wagner, John P Headrick
Bilirubin, a potentially toxic catabolite of heme and indicator of hepato-biliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with individuals usually informed by their clinician that their condition is of little consequence. However, GS appears to protect from all-cause mortality, with progressively elevated total bilirubin associated with protection from ischemic heart and chronic obstructive pulmonary diseases...
March 30, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29600768/the-hepato-protective-effects-of-portulaca-oleracea-l-extract-review
#12
Tahereh Farkhondeh, Saeed Samarghandian, Mohsen Azimi-Nezhad, Soroush Hozeifi
Portulaca oleracea L. (Purslane) has been used in traditional medicine against hepatic injury, alt-hough its actual efficacy has not been fully understood. In addition, few studies have indicated that Portulaca oleracea L. possess protective effects against hepatotoxic agents. However, due to lack of information in human, more studies are needed to confirm the efficacy of Portulaca oleracea L. as a hepato-protective agent. The present study aimed to critically review the recent literature data from 1990 to 2017 regarding the hepato-protective effects of Portulaca oleracea L...
March 30, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29594109/impact-of-three-dimensional-surgical-simulation-on-pancreatic-surgery
#13
Ryoichi Miyamoto, Yukio Oshiro, Ken Nakayama, Nobuhiro Ohkohchi
Background/Aims: Anatomical variations are frequently encountered during hepato-biliary-pancreatic surgeries, requiring surgeons to have a precise understanding of the surgical anatomy in order to perform a safe surgery. We evaluated the impact of novel three-dimensional (3D) surgical simulation on pancreatic surgeries to enhance surgical residents' understanding. Methodology: Between January 2013 and May 2014, 61 preoperative 3D surgical simulations were performed...
February 2018: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/29578250/vasopressin-and-nitroglycerin-decrease-portal-and-hepatic-venous-pressure-and-hepato-splanchnic-blood-flow
#14
E Wisén, K Svennerholm, L S Bown, E Houltz, M Rizell, S Lundin, S-E Ricksten
BACKGROUND: Various methods are used to reduce venous blood pressure in the hepato-splanchnic circulation, and hence minimise blood loss during liver surgery. Previous studies show that combination of vasopressin and nitroglycerin reduces portal pressure and flow in patients with portal hypertension, and in this study we investigated this combination in patients with normal portal pressure. METHOD: In all, 13 patients were studied. Measurements were made twice to confirm baseline (C1 and BL), during vasopressin infusion 4...
March 26, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29576698/ameliorative-effect-of-camel-s-milk-and-nigella-sativa-oil-against-thioacetamide-induced-hepatorenal-damage-in-rats
#15
Aftab Ahmad, Fahad A Al-Abbasi, Saida Sadath, Soad Shaker Ali, Mohammed F Abuzinadah, Hani A Alhadrami, Anwar Ali Mohammad Alghamdi, Ali H Aseeri, Shah Alam Khan, Asif Husain
Background: Camel milk (CM) and Nigella sativa (NS) have been traditionally claimed to cure wide range of diseases and used as medicine in different part of world, particularly in Saudi Arabia. Several research studies have been published that proved beneficial effects of CM and NS. Objective: This study was undertaken to investigate the antihepatotxic potential of CM and NS oil (NSO) against thioacetamide (TAA)-induced hepato and nephrotoxicity in rats. Materials and Methods: Thirty female Albino Wistar rats were randomly divided in to six groups having five rats in each group...
January 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29575875/assessment-of-the-efficacy-of-ofatumumab-in-patients-with-chronic-lymphocytic-leukaemia-treated-in-the-department-of-haematooncology-and-bone-marrow-transplantation-of-the-medical-university-in-lublin-prelimary-results
#16
Ewa Wąsik-Szczepanek, Agnieszka Szymczyk, Małgorzata Kowal, Adam Nogalski, Marek Hus
INTRODUCTION: Despite significant recent advances in the treatment of chronic lymphocytic leukaemia (CLL), most cases of the disease are still incurable. Treatment with monoclonal antibodies, such as ofatumumab, is one of the new therapeutic options. OBJECTIVE: Retrospective analysis of the efficacy of ofatumumab in patients with chronic lymphocytic leukaemia (CLL) treated in the Haematooncology and Bone Marrow Transplantation Department of the Medical University of Lublin, Poland, during 2011-2013...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29574408/european-evidence-based-guidelines-on-pancreatic-cystic-neoplasms
#17
(no author information available yet)
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology)...
March 24, 2018: Gut
https://www.readbyqxmd.com/read/29564518/hospital-teaching-status-and-medicare-expenditures-for-hepato-pancreato-biliary-surgery
#18
Qinyu Chen, Fabio Bagante, Katiuscha Merath, Jay Idrees, Eliza W Beal, Jordan Cloyd, Mary Dillhoff, Carl Schmidt, Adrian Diaz, Susan White, Timothy M Pawlik
BACKGROUND: The association of hospital teaching status and overall expenditures has not been studied among patients undergoing hepato-pancreato-biliary (HPB) surgery. We sought to define the impact of hospital teaching intensity on payments and charges associated with (HPB) surgery from the payer perspective. METHODS: Surgical patients undergoing HPB procedures were identified using 2013-2015 Medicare Provider Analysis and Review (MEDPAR) data. Hospital teaching intensity was categorized based on hospital resident-to-bed ratio: non-teaching (NTH: 0), minor teaching (minor-TH: 0-0...
March 21, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29554944/first-report-of-leishmania-infantum-infection-in-the-endangered-orangutan-pongo-pygmaeus-pygmaeus-in-madrid-spain
#19
Guadalupe Miró, Amelia Troyano, Ana Montoya, Fernando Fariñas, Ma Luisa Fermín, Luís Flores, Carlos Rojo, Rocío Checa, Rosa Gálvez, Valentina Marino, Cristina Fragío, Eva Martínez-Nevado
BACKGROUND: Some wild animals have been recognized as potential reservoirs of Leishmania infantum infection (e.g. carnivores, lagomorphs, rodents, etc.). Leishmania infantum was also identified infecting humans and lagomorphs (i.e. hares and rabbits) over the period of 2009-2016, with the latter acting as the main reservoirs involved in the human leishmaniosis outbreak in Madrid. RESULTS: Two cases of clinical leishmaniosis are reported in orangutans (Pongo pygmaeus pygmaeus) housed at two different centres in Madrid...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29552394/diffuse-optical-monitoring-of-peripheral-tissues-during-uncontrolled-internal-hemorrhage-in-a-porcine-model
#20
Karthik Vishwanath, Rajan Gurjar, David Wolf, Suzannah Riccardi, Michael Duggan, David King
Reliable, continuous and noninvasive blood flow and hemoglobin monitoring in trauma patients remains a critical, but generally unachieved goal. Two optical sensing methods - diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) - are used to monitor and detect internal hemorrhage. Specifically, we investigate if cutaneous perfusion measurements acquired using DCS and DRS in peripheral (thighs and ear-lobe) tissues could detect severe hemorrhagic shock in a porcine model. Four animals underwent high-grade hepato-portal injury in a closed abdomen, to induce uncontrolled hemorrhage and were subsequently allowed to bleed for 10 minutes before fluid resuscitation...
February 1, 2018: Biomedical Optics Express
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