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https://www.readbyqxmd.com/read/29667208/the-use-of-cardiac-ct-alone-to-exclude-left-atrial-thrombus-before-atrial-fibrillation-ablation-efficiency-safety-and-cost-analysis
#1
Wassim Mosleh, Ali Sheikh, Zaid Said, Mohamed A Abdel-Aal, Siri Gadde, Tanvi Shah, Michael F Wilson, Hiroko Beck, Chee Kim, Umesh C Sharma
BACKGROUND: Atrial fibrillation (AF) is a growing financial burden on the healthcare system. Cardiac computed tomographic angiography (CCTA) is needed for pulmonary vein mapping before AF ablation (AFA). CCTA has shown to be an alternative to transesophageal echocardiogram (TEE) to rule-out left atrial appendage thrombus (LAAT) pre-AFA. We aim to examine the safety, cost-effectiveness, and time-efficiency of utilizing CCTA alone to rule out LAAT before AFA. METHODS: We prospectively screened patients with paroxysmal AF undergoing cryoablation...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29623998/prevalence-of-pathogenicity-island-ett2-in-escherichia-coli-isolated-from-piglets-with-diarrhea-in-northeast-of-china
#2
C W Yuan, W X Liu, J L Hou, L G Zhang, G Q Wang
Our aim was to investigate the prevalence of the pathogenicity island ETT2 and to examine the relationship between the ETT2 locus and other virulence factors in Escherichia coli (E. coli) isolated from piglets with diarrhea. A total of 354 E. coli strains isolated from scouring piglets were tested using PCR for the presence of the ETT2 locus. The E. coli strains were also analyzed for enterotoxins, fimbriae, non-fimbrial adhesin, Shiga toxins, pathogenicity islands, α-haemolysin (hlyA), afa8 gene cluster and autotransporter protease (sepA) genes...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29615845/novel-mutation-in-abbc9-gene-associated-with-congenital-hypertrichosis-and-acromegaloid-facial-features-without-cardiac-or-skeletal-anomalies-a-new-phenotype
#3
Harry Pachajoa, William López-Quintero, Sara Vanegas, Claudia L Montoya, Diana Ramírez-Montaño
Introduction: Mutations in ABCC9 are associated with Cantú syndrome (CS), a very rare genetic disorder characterized by congenital hypertrichosis, acromegaloid facial appearance (AFA), cardiomegaly, and skeletal anomalies. Case report: We report an 8-year-old female patient with congenital generalized hypertrichosis and coarse facial appearance but without cardiovascular or skeletal compromise. Whole exome sequencing revealed a novel de novo heterozygous mutation in ABCC9 ...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29609144/a-thermodynamics-based-approach-for-examining-the-suitability-of-cementitious-formulations-for-solidifying-and-stabilizing-coal-combustion-wastes
#4
Monday Uchenna Okoronkwo, Magdalena Balonis, Lynn Katz, Maria Juenger, Gaurav Sant
Cementitious binders are often used to immobilize industrial wastes such as residues of coal combustion. Such immobilization stabilizes wastes that contain contaminants by chemical containment, i.e., by uptake of contaminants into the cementitious reaction products. Expectedly, the release ("leachability") of contaminants is linked to: (i) the stability of the matrix (i.e., its resistance to decomposition on exposure to water), and, (ii) its porosity, which offers a pathway for the intrusion of water and egress of contaminant species...
March 30, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29567575/comparative-studies-on-the-human-serum-albumin-binding-of-the-clinically-approved-egfr-inhibitors-gefitinib-erlotinib-afatinib-osimertinib-and-the-investigational-inhibitor-kp2187
#5
Orsolya Dömötör, Karla Pelivan, Attila Borics, Bernhard K Keppler, Christian R Kowol, Éva A Enyedy
Binding interactions between human serum albumin (HSA) and four approved epidermal growth factor receptor (EGFR) inhibitors gefitinib (GEF), erlotinib (ERL), afatinib (AFA), osimertinib (OSI), as well as the experimental drug KP2187, were investigated by means of spectrofluorometric and molecular modelling methods. Steady-state and time resolved spectrofluorometric techniques were carried out, including direct quenching of protein fluorescence and site marker displacement measurements. Proton dissociation processes and solvent dependent fluorescence properties were investigated as well...
March 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29552607/water-quality-assessment-for-groundwater-around-a-municipal-waste-dumpsite
#6
Olusola T Kayode, Hilary I Okagbue, Justina A Achuka
The dataset for this article contains geostatistical analysis of the level to which groundwater quality around a municipal waste dumpsite located in Oke-Afa, Oshodi/Isolo area of Lagos state, southwestern has been compromised for drinking. Groundwater samples were collected from eight hand-dug wells and two borehole wells around or near the dumpsite. The pH, turbidity, salinity, conductivity, total hydrocarbon, total dissolved solids (TDS), dissolved oxygen, chloride, Sulphate (SO4 ), Nitrate (NO3 ) and Phosphate (PO4 ) were determined for the water samples and compared with World Health Organization (WHO) drinking water standard...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29551444/-characterization-of-extraintestinal-pathogenic-escherichia-coli-strains-isolated-from-household-dogs-and-cats-in-buenos-aires-argentina
#7
Cecilia C Cundon, Alejandro Ameal, Elsa Maubecín, Adriana Bentancor
The pangenome of Escherichia coli is composed of a conserved core and variable genomic regions. The constant genetic component allows to determine the phylogeny of the microorganism, while genetic variability promoted the emergence of intestinal pathogenic strains and extraintestinal strains. In this study we characterized 85 extraintestinal pathogenic isolates genetically isolated from canines and felines. We used the Clermont scheme that includes intestinal (A and B1) and extraintestinal (B2 and D) phylogroups, virulence markers (pap1-2, pap3-4, sfa, afa, hlyA, aer and cnf) and hybrid pathogens...
March 15, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29522788/urinary-afamin-levels-are-associated-with-the-progression-of-diabetic-nephropathy
#8
Yasushi Kaburagi, Eri Takahashi, Hiroshi Kajio, Shigeo Yamashita, Ritsuko Yamamoto-Honda, Tomoko Shiga, Akinori Okumura, Atsushi Goto, Yuka Fukazawa, Naoto Seki, Kazuyuki Tobe, Michihiro Matsumoto, Mitsuhiko Noda, Hiroyuki Unoki-Kubota
AIMS: In this study, we applied quantitative proteomic analysis to identify urinary proteins associated with diabetic nephropathy (DN). METHODS: Two-dimensional image-converted analysis of liquid chromatography and mass spectrometry detected the proteins differentially excreted between normoalbuminuric and macroalbuminuric patients with type 2 diabetes mellitus (T2DM) (n = 6 each). Urinary levels of excreted proteins were measured by multiple reaction monitoring (MRM) analysis using an independent sample set (n = 77)...
March 6, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29507038/eyes-that-cannot-be-seen-a-rare-case-of-ankyloblepharon-filiforme-adnatum-afa-in-a-neonate
#9
Nripen Gaur, Rachna Meel, Adarsh Shashni, Nawazish Shaikh
No abstract text is available yet for this article.
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29471688/plasmid-mediated-quinolone-resistance-determinants-in-enterobacteriaceae-from-urine-clinical-samples
#10
Orsolya Szabó, Dániel Gulyás, Nikolett Szabó, Katalin Kristóf, Béla Kocsis, Dóra Szabó
Plasmid-mediated quinolone resistance (PMQR) determinants including, qnrA, qnrB, qnrC, qnrD, qnrS, aac(6')-Ib-cr, oqxAB, and qepA, were investigated in 214 Enterobacteriaceae strains from urine clinical samples. Antimicrobial susceptibility testing for ciprofloxacin, ceftriaxone, and imipenem was performed by broth microdilution method. All strains were screened for PMQR genes by PCR. Virulence determinants, namely afa, pap, pil, sfa/foc, and kpsMT of eight Escherichia coli strains proven positive for at least one qnr gene, were investigated by PCR...
February 23, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29409246/prospective-study-of-the-inside-out-arthroscopic-ankle-ligament-technique-preliminary-result
#11
Caio Nery, Lucas Fonseca, Fernando Raduan, Marcus Moreno, Daniel Baumfeld
BACKGROUND: Lateral ankle ligament injury is among the most common orthopedic injuries. The objective of this study is to present the preliminary prospective results of treatment using the "Inside-Out" variant of the fully arthroscopic Broström-Gould technique. METHODS: Twenty six patients were included: 20 male and 6 female, aged 19-60 years, mean 41 years. All patients had positive "anterior drawer" and "talar tilt" tests. When necessary, cartilage injuries were treated with microfracture and arthroscopic resection for anterior impingement; three patients had hindfoot varus, on whom Dwyer osteotomy was performed; one patient had peroneal tendinopathy and was treated with tendoscopic debridement and another one had partial injury of the deltoid ligament, which was treated by direct repair...
March 22, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29396034/epidemiology-clinical-characteristics-and-associations-for-symptom-based-rome-iv-functional-dyspepsia-in-adults-in-the-usa-canada-and-the-uk-a-cross-sectional-population-based-study
#12
Imran Aziz, Olafur S Palsson, Hans Törnblom, Ami D Sperber, William E Whitehead, Magnus Simrén
BACKGROUND: The population prevalence, clinical characteristics, and associations for Rome IV functional dyspepsia are not known. Following the publication of the Rome IV criteria for functional gastrointestinal disorders, we aimed to assess the prevalence, characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults across the USA, Canada, and the UK. METHODS: We sent an internet-based cross-sectional health survey to adults in the general population of three English-speaking countries: the USA, Canada, and the UK...
January 29, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29357037/blood-threshold-cmr-volume-analysis-of-functional-univentricular-heart
#13
Francesco Secchi, Marco Alì, Marcello Petrini, Francesca Romana Pluchinotta, Andrea Cozzi, Mario Carminati, Francesco Sardanelli
PURPOSE: To validate a blood-threshold (BT) segmentation software for cardiac magnetic resonance (CMR) cine images in patients with functional univentricular heart (FUH). MATERIALS AND METHODS: We evaluated retrospectively 44 FUH patients aged 25 ± 8 years (mean ± standard deviation). For each patient, the epicardial contour of the single ventricle was manually segmented on cine images by two readers and an automated BT algorithm was independently applied to calculate end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and cardiac mass (CM)...
May 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29245847/attosecond-sublevel-beating-and-nonlinear-dressing-on-the-3d-to-5p-and-3p-to-5s-core-transitions-at-91-3-ev-and-210-4-ev-in-krypton
#14
Enikoe Seres, Jozsef Seres, Shinichi Namba, John Afa, Carles Serrat
Applying extreme ultraviolet (XUV) transient absorption spectroscopy, the dynamics of the two laser dressed transitions 3d5/2 -to-5p3/2 and 3p3/2 -to-5s1/2 at photon energies of 91.3 eV and 210.4 eV were examined with attosecond temporal resolution. The dressing process was modeled with density matrix equations which are found to describe very accurately both the experimentally observed transmission dynamics and the linear and nonlinear dressing oscillations at 0.75 PHz and 1.5 PHz frequencies. Furthermore, using Fourier transform XUV spectroscopy, quantum beats from the 3d5/2 -3d3/2 and 3p3/2 -3p1/2 sublevels at 0...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29226929/synergistic-arsenic-v-and-lead-ii-retention-on-synthetic-jarosite-i-simultaneous-structural-incorporation-behaviour-and-mechanism
#15
J Aguilar-Carrillo, M Villalobos, T Pi-Puig, I N Escobar-Quiroz, F M Romero
Jarosite [KFe3 (SO4 )2 (OH)6 ] minerals are effective scavengers of potentially toxic elements (PTEs) and are abundant, for example, in acid rock/mine drainage scenarios. The retention process is highly relevant for environmental attenuation of heavy metals and metalloids since these are usually highly soluble and thus mobile under acidic conditions. We investigated both macroscopically and at the molecular scale the extent and the effects of concomitant incorporation of As(v) and Pb(ii) into synthetic jarosite at different As/Pb starting molar ratios, using XRD-Rietveld, SEM, ATR-FTIR spectroscopy and wet chemistry...
February 21, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29224265/-analysis-on-the-clinical-therapeutic-effects-of-arterial-first-approach-pancreatoduodenectomy-in-the-treatment-of-borderline-resectable-pancreatic-adenocarcinoma
#16
G Jin, K L Zheng, S W Guo, Z Shao, C Liu, X H Shi, R D Liu, S J Bai, H Jiang, Y Bian, X G Hu
Objective: To compare the clinical therapeutic effects of arterial first approach pancreaticoduodenectomy(AFA-PD) with standard approach pancreaticoduodenectomy(SPD) in the treatment of borderline resectable pancreatic cancer (BRPC). Methods: A retrospective analysis of the clinical data of 113 cases of pancreatic cancer patients from January 2014 to August 2015 at Department of Hepato-Biliary-Pancreatic Surgery, Changhai Hospital, the Second Military Medical University, including 43 cases in AFA-PD group and 70 cases in SPD group...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29199378/distribution-of-pathogenicity-island-markers-and-virulence-factors-in-new-phylogenetic-groups-of-uropathogenic-escherichia-coli-isolates
#17
Akram Najafi, Mojtaba Hasanpour, Azam Askary, Masoud Aziemzadeh, Najmeh Hashemi
The present study was aimed at investigating the relationship between the new Clermont's phylogenetic groups, virulence factors, and pathogenicity island markers (PAIs) among uropathogenic Escherichia coli (UPEC) in Iran. This cross-sectional study was carried out on 140 UPEC isolates collected from patients with urinary tract infections in Bushehr, Iran. All isolates were subjected to phylogenetic typing using a new quadruplex-PCR method. The presence of PAI markers and virulence factors in UPEC strains was evaluated by multiplex PCR...
December 3, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28993899/industrial-antifoam-agents-impair-ethanol-fermentation-and-induce-stress-responses-in-yeast-cells
#18
Jens Christian Nielsen, Felipe Senne de Oliveira Lino, Thomas Gundelund Rasmussen, Jette Thykær, Christopher T Workman, Thiago Olitta Basso
The Brazilian sugarcane industry constitutes one of the biggest and most efficient ethanol production processes in the world. Brazilian ethanol production utilizes a unique process, which includes cell recycling, acid wash, and non-aseptic conditions. Process characteristics, such as extensive CO2 generation, poor quality of raw materials, and frequent contaminations, all lead to excessive foam formation during fermentations, which is treated with antifoam agents (AFA). In this study, we have investigated the impact of industrial AFA treatments on the physiology and transcriptome of the industrial ethanol strain Saccharomyces cerevisiae CAT-1...
November 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28956697/annurca-apple-nutraceutical-formulation-enhances-keratin-expression-in-a-human-model-of-skin-and-promotes-hair-growth-and-tropism-in-a-randomized-clinical-trial
#19
Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D'Avino, Rita Santamaria, Carlo Irace, Marialuisa Piccolo, Maria Maisto, Ettore Novellino
Several pharmaceutical products have been formulated over the past decades for the treatment of male and female alopecia, and pattern baldness, but relatively few metadata on their efficacy have been published. For these reasons, the pharmaceutical and medical attention has recently focused on the discovery of new and safer remedies. Particularly, great interest has been attracted by oligomeric procyanidin bioactivity, able to promote hair epithelial cell growth as well as to induce the anagen phase. Specifically, the procyanidin B2, a dimeric derivative extracted from apples, has demonstrated to be one of the most effective and safest natural compounds in promoting hair growth, both in vitro and in humans by topical applications...
January 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28891362/alternatives-to-antibiotics-in-poultry-feed-molecular-perspectives
#20
Gayatri Suresh, Ratul Kumar Das, Satinder Kaur Brar, Tarek Rouissi, Antonio Avalos Ramirez, Younes Chorfi, Stephane Godbout
The discovery of the growth promoting property of antibiotics led to their use as antibiotic feed additives (AFAs) in animal feed at sub-therapeutic doses. Although this has been beneficial for animal health and productivity, it has been, essentially, a double-edged sword. The continued and non-judicious use of AFAs has led to the selection and dissemination of antibiotic-resistant strains of poultry pathogens such as Salmonella, Campylobacter and Escherichia coli. The rapid spread of drug-resistant pathogens as well as emergence of antibiotic-related environmental pollutants is of global concern...
September 11, 2017: Critical Reviews in Microbiology
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