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Functional muscle transfer

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https://www.readbyqxmd.com/read/29343714/endothelial-nitric-oxide-synthase-overexpressing-human-early-outgrowth-cells-inhibit-coronary-artery-smooth-muscle-cell-migration-through-paracrine-functions
#1
Sergio Guber, Talin Ebrahimian, Maryam Heidari, Nicoletta Eliopoulos, Stephanie Lehoux
Cells mobilized from the bone marrow can contribute to endothelial regeneration and repair. Nevertheless, cardiovascular diseases are associated with diminished numbers and function of these cells, attenuating their healing potential. Gene transfer of endothelial nitric oxide synthase (eNOS) can restore the activity of circulating cells. Furthermore, estrogen accelerates the reendothelialization capacity of early outgrowth cells (EOCs). We hypothesized that overexpressing eNOS alone or in combination with estrogen stimulation in EOCs would potentiate the beneficial effects of these cells in regulating smooth muscle cell (SMC) function...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337028/bipolar-pedicled-teres-major-transfer-for-irreparable-subscapularis-tendon-tears-an-anatomic-feasibility-study
#2
Thibault Lafosse, Malo Le Hanneur, Julia Lee, Bassem Elhassan
BACKGROUND: Subscapularis (SSC) tendon tears are a challenging problem because they can significantly alter shoulder mechanics and function. Tendon retraction and advanced fatty degeneration associated with a chronic tear may make it irreparable. Tendon transfers options for such tears are viable, but results in the setting of associated glenohumeral instability are inconsistent. With the potential to recreate the SSC line of pull, the teres major (TM) may be a viable option for transfer...
January 12, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29328915/retrovirus-like-gag-protein-arc1-binds-rna-and-traffics-across-synaptic-boutons
#3
James Ashley, Benjamin Cordy, Diandra Lucia, Lee G Fradkin, Vivian Budnik, Travis Thomson
Arc/Arg3.1 is required for synaptic plasticity and cognition, and mutations in this gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral/retrotransposon Gag-like proteins, which multimerize into a capsid that packages viral RNA. The significance of such a domain in a plasticity molecule is uncertain. Here, we report that the Drosophila Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and is loaded into extracellular vesicles that are transferred from motorneurons to muscles...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29311017/reanimation-of-the-paralyzed-lids-by-cross-face-nerve-graft-and-platysma-transfer
#4
Federico Biglioli, Matteo Zago, Fabiana Allevi, Daniela Ciprandi, Giovanni Dell'Aversana Orabona, Valentina Pucciarelli, Dimitri Rabbiosi, Ilaria Pacifici, Filippo Tarabbia, Chiarella Sforza
Alterations of facial muscles may critically humper patients' quality of life. One of the worst conditions is the reduction or abolition of eye blinking. To prevent these adverse effects, surgical rehabilitation of eyelid function is the current treatment choice. In the present paper, we present a modification of the technique devised by Nassif to recover lids from long-standing paralysis. In our modification, the upper lid is rehabilitated by a platisma graft innervated by the contralateral facial nerve branches using a cross-face sural nerve graft...
December 27, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29309351/unit-advancement-flap-for-lower-lip-reconstruction
#5
Akihiro Ogino, Kiyoshi Onishi, Emi Okada, Miho Nakamichi
BACKGROUND: Lower lip reconstruction requires consideration of esthetic and functional outcome in selecting a surgical procedure, and reconstruction with local tissue is useful. The authors reconstructed full-thickness defects with a unit advancement flap. METHODS: Reconstruction was performed using this method in 4 patients with lower lip squamous cell carcinoma in whom tumor resection with preservation of the mouth angle was possible. The lower lip resection width was 30 to 45 mm, accounting for 50% to 68% of the entire width of the lower lip...
January 5, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29305060/does-ipsilateral-corticospinal-excitability-play-a-decisive-role-in-the-cross-education-effect-caused-by-unilateral-resistance-training-a-systematic-review
#6
D Colomer-Poveda, S Romero-Arenas, T Hortobagyi, G Márquez
INTRODUCTION: Unilateral resistance training has been shown to improve muscle strength in both the trained and the untrained limb. One of the most widely accepted theories is that this improved performance is due to nervous system adaptations, specifically in the primary motor cortex. According to this hypothesis, increased corticospinal excitability (CSE), measured with transcranial magnetic stimulation, is one of the main adaptations observed following prolonged periods of training...
January 2, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29299228/comparison-of-strategies-and-performance-of-functional-electrical-stimulation-cycling-in-spinal-cord-injury-pilots-for-competition-in-the-first-ever-cybathlon
#7
Christine Azevedo Coste, Vance Bergeron, Rik Berkelmans, Emerson Fachin Martins, Ché Fornusek, Arnin Jetsada, Kenneth J Hunt, Raymond Tong, Ronald Triolo, Peter Wolf
Functional Electrical Stimulation (FES) can elicit muscular contraction and restore motor function in paralyzed limbs. FES is a rehabilitation technique applied to various sensorimotor deficiencies and in different functional situations, e.g. grasping, walking, standing, transfer, cycling and rowing. FES can be combined with mechanical devices. FES-assisted cycling is mainly used in clinical environments for training sessions on cycle ergometers, but it has also been adapted for mobile devices, usually tricycles...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29299222/functional-electrical-stimulation-cycling-strategies-tested-during-preparation-for-the-first-cybathlon-competition-a-practical-report-from-team-ens-de-lyon
#8
Amine Metani, Lana Popović-Maneski, Sebastien Mateo, Laura Lemahieu, Vance Bergeron
Whether it is from the patient's or the physical therapist's point of view, FES cycling can be considered either as a recreational activity, or an engaging rehabilitation tool. In both cases, it keeps patients with lower-limb paralysis motivated to sustain a regular physical activity. Thus, it is not surprising that it was selected as one of the six disciplines of the first Cybathlon competition held on October 8, 2016. However, many unresolved issues prevent FES cycling from being an activity practiced outdoors on a daily basis; such as, low power production, rapid muscle fatigue, precise electrode positioning, lack of systematic procedures to determine stimulation patterns, and the difficulty of transferring disabled riders from their wheelchair to the tricycle...
December 5, 2017: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29291295/radial-to-axillary-nerve-transfer
#9
Vicente Vanaclocha, Juan Manuel Herrera, Marlon Rivera-Paz, Deborah Martínez-Gómez, Leyre Vanaclocha
Axillary nerve injury is common after brachial plexus injuries, particularly with shoulder luxation. Nerve grafting is the traditional procedure for postganglionic injuries. Nerve transfer is emerging as a viable option particularly in late referrals. At the proximal arm the radial and axillary nerves lie close by. Sacrificing one of the triceps muscle nerve branches induces little negative consequences. Transferring the long head of the triceps nerve branch is a good option to recover axillary nerve function...
January 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29290606/isolated-loss-of-active-external-rotation-a-distinct-entity-and-results-of-l-episcopo-tendon-transfer
#10
Pascal Boileau, Mohammed Baba, Walter B McClelland, Charles-Édouard Thélu, Christophe Trojani, Nicolas Bronsard
BACKGROUND: The purpose of this study was to characterize a subgroup of cuff-deficient patients with isolated loss of active external rotation (ILER) but preserved active elevation and to evaluate the outcomes of the L'Episcopo procedure to restore horizontal muscle balance. METHODS: During a 10-year period, 26 patients (14 men, 12 women) were identified with ILER in the setting of massive irreparable posterosuperior cuff tears. A modified L'Episcopo tendon transfer was performed to restore active external rotation and to improve shoulder function...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29285664/pectoralis-minor-transfer-for-elbow-flexion-restoration-in-late-obstetric-brachial-plexus-palsy
#11
Vanessa Costil, Claudia Romana, Frank Fitoussi
PURPOSE: Obstetric brachial plexus palsy (OBPP) may result in a severe impairment of upper limb function, especially when major motor functions do not recover with or without early microsurgical reconstruction. Various methods to restore elbow flexion have been described. The aim of this study was to report the results after pectoralis minor transfer for elbow flexion restoration in late OBPP. METHODS: Nineteen patients were included. Mean age at surgery was six years (range, 2...
December 28, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29284662/junctional-trafficking-and-restoration-of-retrograde-signaling-by-the-cytoplasmic-ryr1-domain
#12
Alexander Polster, Stefano Perni, Dilyana Filipova, Ong Moua, Joshua D Ohrtman, Hicham Bichraoui, Kurt G Beam, Symeon Papadopoulos
The type 1 ryanodine receptor (RyR1) in skeletal muscle is a homotetrameric protein that releases Ca2+ from the sarcoplasmic reticulum (SR) in response to an "orthograde" signal from the dihydropyridine receptor (DHPR) in the plasma membrane (PM). Additionally, a "retrograde" signal from RyR1 increases the amplitude of the Ca2+ current produced by CaV1.1, the principle subunit of the DHPR. This bidirectional signaling is thought to depend on physical links, of unknown identity, between the DHPR and RyR1. Here, we investigate whether the isolated cytoplasmic domain of RyR1 can interact structurally or functionally with CaV1...
December 28, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29282488/outcome-of-surgery-for-nerve-injury-following-total-hip-arthroplasty
#13
James W Pritchett
PURPOSE: During hip replacement, nerves in the operative field can be injured accidently. Additional surgical procedures can help restore function and reduce pain if there has been no recovery. METHODS: One-hundred sixty-two patients presented with nerve injuries, and 113 were candidates for surgical treatment. The author performed 91 procedures on the injured limb (80 patients; 11 had 2 procedures) consisting of shortening, sympathectomy, tendon transfer, neurolysis or nerve repair/graft and 30 spinal and three fibular-neck decompressions...
December 28, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29280873/comparison-of-surgical-strategies-between-proximal-nerve-graft-and-or-nerve-transfer-and-distal-nerve-transfer-based-on-functional-restoration-of-elbow-flexion-a-retrospective-review-of-147-patients
#14
COMPARATIVE STUDY
Ching-Hsuan Hu, Tommy Nai-Jen Chang, Johnny Chuieng-Yi Lu, Vincent G Laurence, David Chwei-Chin Chuang
BACKGROUND: Surgical strategy to treat incomplete brachial plexus injury with palsies of the shoulder and elbow by using proximal nerve graft/transfer or distal nerve transfer is still debated. The aim of this study was to compare both strategies with respect to the recovery of elbow flexion. METHODS: One hundred forty-seven patients were enrolled: 76 patients underwent reconstruction using proximal nerve graft/transfer, and 71 patients underwent reconstruction using distal nerve transfer...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29276759/in-vivo-multiscale-and-spatially-dependent-biomechanics-reveals-differential-strain-transfer-hierarchy-in-skeletal-muscle
#15
Soham Ghosh, James G Cimino, Adrienne K Scott, Frederick W Damen, Evan H Phillips, Alexander I Veress, Corey P Neu, Craig J Goergen
Biological tissues have a complex hierarchical architecture that spans organ to subcellular scales and comprises interconnected biophysical and biochemical machinery. Mechanotransduction, gene regulation, gene protection, and structure-function relationships in tissues depend on how force and strain are modulated from macro to micro scales, and vice versa. Traditionally, computational and experimental techniques have been used in common model systems (e.g., embryos) and simple strain measures were applied. But the hierarchical transfer of mechanical parameters like strain in mammalian systems is largely unexplored in vivo...
November 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29260008/functional-validation-and-expression-analysis-of-myotubes-converted-from-skin-fibroblasts-using-a-simple-direct-reprogramming-strategy
#16
Fukuko Horio, Hidetoshi Sakurai, Yutaka Ohsawa, Shiho Nakano, Makoto Matsukura, Isao Fujii
Previously, we reported that MyoD, a master gene for myogenic cells, could efficiently convert primary skin fibroblasts into myoblasts and myotubes, thereby effecting direct reprogramming. In this study, we further demonstrated that MyoD-expressing primary fibroblasts displayed rapid movement in culture, with a movement velocity that was significantly faster, almost four times, than mouse primary myoblasts. MyoD-transduced cells obtained the characteristics of Ca2 + release and electrically-stimulated contraction, which was comparable to C2C12 myotubes, suggesting that the essential features of muscle were observed in the transduced cells...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29246115/training-the-salmon-s-genes-influence-of-aerobic-exercise-swimming-performance-and-selection-on-gene-expression-in-atlantic-salmon
#17
Nicholas A Robinson, Gerrit Timmerhaus, Matthew Baranski, Øivind Andersen, Harald Takle, Aleksei Krasnov
BACKGROUND: Farmed and wild Atlantic salmon are exposed to many infectious and non-infectious challenges that can cause mortality when they enter the sea. Exercise before transfer promotes growth, health and survival in the sea. Swimming performance in juveniles at the freshwater parr stage is positively associated with resistance to some diseases. Genetic variation is likely to affect response to exercise. In this study we map genetic differences associated with aerobic exercise, swimming performance and genetic origin...
December 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29244663/scapular-winging-caused-by-combined-palsy-of-the-spinal-accessory-nerve-and-the-long-thoracic-nerve-a-case-report
#18
Kentaro Ago, Noboru Matsumura, Takuji Iwamoto, Kazuki Sato, Masaya Nakamura, Morio Matsumoto
CASE: A 37-year-old man with scapular winging, caused by combined palsy of the spinal accessory nerve and the long thoracic nerve, was successfully treated with a pectoralis major transfer to substitute for the serratus anterior muscle, and with levator scapulae and rhomboid muscle transfers to substitute for the trapezius muscle. CONCLUSION: The serratus anterior paralysis was thought to have occurred secondary to traction of the long thoracic nerve by the unsupported scapula following the spinal accessory nerve palsy...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29242789/giant-cell-tumor-of-metacarpal-in-the-skeletally-immature-patient-and-free-osteoarticular-metatarsal-transfer-review-of-literature-with-case-report
#19
Pankaj Kumar Mishra, Yash Agarwal, Prakhar Singhal, Kripa Shankar Mishra
Introduction: In the customary wisdom, it is conceded that giant-cell tumor (GCT) is a pathology of fused epiphysis, but there are literatures available to depict that even though rare bit, but it occurs in the skeletally immature patients. Here, we are presenting a rare case of GCT of the fifth metacarpal in the skeletally immature patient. Case Report: It is a case report of a 13-year-old girl with the history of swelling over her right hand for 5 months. X-ray revealed that there was an osteolytic fusiform expansible lesion...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242210/reversible-immortalisation-enables-genetic-correction-of-human-muscle-progenitors-and-engineering-of-next-generation-human-artificial-chromosomes-for-duchenne-muscular-dystrophy
#20
Sara Benedetti, Narumi Uno, Hidetoshi Hoshiya, Martina Ragazzi, Giulia Ferrari, Yasuhiro Kazuki, Louise Anne Moyle, Rossana Tonlorenzi, Angelo Lombardo, Soraya Chaouch, Vincent Mouly, Marc Moore, Linda Popplewell, Kanako Kazuki, Motonobu Katoh, Luigi Naldini, George Dickson, Graziella Messina, Mitsuo Oshimura, Giulio Cossu, Francesco Saverio Tedesco
Transferring large or multiple genes into primary human stem/progenitor cells is challenged by restrictions in vector capacity, and this hurdle limits the success of gene therapy. A paradigm is Duchenne muscular dystrophy (DMD), an incurable disorder caused by mutations in the largest human gene: dystrophin. The combination of large-capacity vectors, such as human artificial chromosomes (HACs), with stem/progenitor cells may overcome this limitation. We previously reported amelioration of the dystrophic phenotype in mice transplanted with murine muscle progenitors containing a HAC with the entire dystrophin locus (DYS-HAC)...
December 14, 2017: EMBO Molecular Medicine
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