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https://www.readbyqxmd.com/read/28549364/-an-option-to-restore-ulnar-intrinsic-muscles-when-the-anterior-interosseus-nerve-is-not-available
#1
G A González-Trevizo
BACKGROUND: The peripheral nerve injuries are devastating for the patient; the classic reconstructive options are the Nerve Graft and Tendon Transfers. Lately the Nerve Transfers are being used more and more broadly. They are an excellent option on early injuries and when the motor plate is still alive. The advantages are numerous, because the functional recovery is much better. METHODS AND RESULTS: We report the case of a patient who sustained and injury on the median and ulnar nerve, so the EDQ and ECU branches were used to restore the Ulnar Intrinsic Function...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28545516/improving-the-regenerative-potential-of-olfactory-ensheathing-cells-by-overexpressing-prostacyclin-synthetase-and-its-application-in-spinal-cord-repair
#2
May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang, Henrich Cheng
BACKGROUND: Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears to facilitate axonal regeneration although the functional recovery is limited. In an attempt to improve the growth-promoting properties of OEC, we transduced prostacyclin synthase (PGIS) to OEC via adenoviral (Ad) gene transfer and examined the effect of OEC with enhanced prostacyclin synthesis in co-culture and in vivo...
May 25, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28544569/maintenance-of-the-contractile-phenotype-in-corpus-cavernosum-smooth-muscle-cells-by-myocardin-gene-therapy-ameliorates-erectile-dysfunction-in-bilateral-cavernous-nerve-injury-rats
#3
H-B Zhang, Z-Q Wang, F-Z Chen, W Ding, W-B Liu, Z-R Chen, S-H He, A-Y Wei
The pathophysiology of erectile dysfunction post radical prostatectomy is not clearly clarified, and the low efficacy of traditional PDE5i treatment remains a major complaint in contemporary practice. This study aimed to demonstrate phenotypic modulation in bilateral cavernous nerve injury (BCNI) rats within 7 days, and subsequently validate gene therapy with Myocardin (Mycod) by maintaining a contractile phenotype in corpus cavernosum smooth muscle cells. Initially, 36 male rats were randomly divided into BCNI and negative control (NC) groups for histological and phenotypic molecular measurements at 3, 5, and 7 days...
May 23, 2017: Andrology
https://www.readbyqxmd.com/read/28540442/outcome-after-brachial-plexus-injury-surgery-and-impact-on-quality-of-life
#4
Lukas Rasulić, Andrija Savić, Bojana Živković, Filip Vitošević, Mirko Mićović, Vladimir Baščarević, Vladimir Puzović, Nenad Novaković, Milan Lepić, Miroslav Samardžić, Stefan Mandić-Rajčević
BACKGROUND: The aim of this study was to investigate outcomes after surgery for brachial plexus injury (BPI), not only motor outcomes but also the quality of life of the patients. METHODS: We operated on 128 consecutive patients with BPI from 1992 to 2012. We documented the information on the injured nerve, level of injury, type of treatment used, timing of surgery, patient age, and preoperative and postoperative motor deficits. In 69 patients who agreed to participate in a quality of life study, additional assessments included functionality, pain, quality of life, patient satisfaction, and psychosocial health...
May 24, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28538253/immune-myopathy-with-perimysial-pathology-associated-with-interstitial-lung-disease-and-anti-ej-antibodies
#5
Patrick M Kwon, Lan Zhou, Rajeev Motiwala, Leslie D Kerr, Susan C Shin
OBJECTIVES: We report a case of immune myopathy with perimysial pathology associated with anti-glycyl-transfer RNA synthetase (anti-EJ) antibody and an excellent treatment response. METHODS: Chart review. RESULTS: A 36-year-old woman presented with 3 months of fatigue, weight loss, progressive weakness in a scapuloperoneal distribution, and dysphagia. Nerve conduction studies, electromyography, and ultrasound suggested an irritable myopathy...
June 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28532969/lip-reconstruction-using-a-functioning-serratus-anterior-free-flap-preliminary-study
#6
A O Gundeslioglu, E C Karadag, I Inan, L Jasharllari, M N Selimoglu, F Guney, B Yuruten, M Bekerecioglu
Reconstructive surgery to the lips requires the replacement of defective tissues with similarly functioning tissues. While non-dynamic free tissue transfers provide adequate lower lip reconstruction, improved benefits may be obtained with innervated free muscle flaps. This study reports the use of innervated serratus anterior muscle free flaps for lip reconstruction in five patients. All patients had squamous cell carcinoma of either the upper or lower lip. After resection of the tumours, the resultant defects comprised two-thirds of the lips...
May 19, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28528295/a-machine-learning-graph-based-approach-for-3d-segmentation-of-bruch-s-membrane-opening-from-glaucomatous-sd-oct-volumes
#7
Mohammad Saleh Miri, Michael D Abràmoff, Young H Kwon, Milan Sonka, Mona K Garvin
Bruch's membrane opening-minimum rim width (BMO-MRW) is a recently proposed structural parameter which estimates the remaining nerve fiber bundles in the retina and is superior to other conventional structural parameters for diagnosing glaucoma. Measuring this structural parameter requires identification of BMO locations within spectral domain-optical coherence tomography (SD-OCT) volumes. While most automated approaches for segmentation of the BMO either segment the 2D projection of BMO points or identify BMO points in individual B-scans, in this work, we propose a machine-learning graph-based approach for true 3D segmentation of BMO from glaucomatous SD-OCT volumes...
May 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28521852/upper-limb-nerve-transfers-a-review
#8
A Forli, M Bouyer, M Aribert, C Curvale, M Delord, D Corcella, F Moutet
While upper limb nerve transfers were first described and performed several years ago, they have seen expanded use in the past 20 years. Initially indicated for surgical repair of brachial plexus injuries with nerve root avulsion, the indications have been extended to post-ganglionic lesions because of the excellent results of certain intraplexus nerve transfers. The traditional nerve repair techniques - primary suture and nerve grafting - form the basis of nerve surgery. Although nerve transfer does not replace them, they are a useful supplement as they provide a targeted approach to reinnervation and recovery of key functions of the upper limb...
June 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28521670/intranasal-drug-delivery-a-non-invasive-approach-for-the-better-delivery-of-neurotherapeutics
#9
Umesh Gupta, Hitesh Kumar, Gaurav Mishra, Ashok Kumar Sharma, Avinash Gothwal, Prashant Kesharwani
BACKGROUND: The convoluted pathophysiology of brain disorders along with penetration issue of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo, to overcome this barrier intranasal delivery is an excellent strategy to deliver the drug directly to brain via olfactory and trigeminal nerve pathways that originate as olfactory neuro-epithelium in the nasal cavity and terminate in brain...
May 14, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28507235/assessing-the-strength-of-cardiac-and-sympathetic-baroreflex-controls-via-transfer-entropy-during-orthostatic-challenge
#10
Alberto Porta, Andrea Marchi, Vlasta Bari, Beatrice De Maria, Murray Esler, Elisabeth Lambert, Mathias Baumert
The study assesses the strength of the causal relation along baroreflex (BR) in humans during an incremental postural challenge soliciting the BR. Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart period (HP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and muscle sympathetic nerve activity (MSNA). A model-based transfer entropy method was applied to quantify the strength of the coupling from SAP to HP and from DAP to MSNA...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28506179/value-of-soft-tissue-release-procedure-around-the-shoulder-to-improve-shoulder-abduction-in-birth-brachial-plexus-palsy-and-analysis-of-the-factors-affecting-outcome
#11
S Raja Sabapathy, Praveen Bhardwaj, Hari Venkatramani
BACKGROUND: A lack of shoulder abduction in spontaneously recovered birth brachial plexus palsy (BBPP) is a common presentation. We have performed a soft tissue release operation in these patients to remove the tethering effect of the tight and cocontracting shoulder adductors. This study was undertaken in order to assess the outcome of this surgical procedure. METHODS: We performed a retrospective analysis of 120 patients who displayed spontaneous recovery from BBPP and subsequently underwent soft tissue release procedure to improve shoulder abduction...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28506157/motor-and-sensory-cortical-changes-after-contralateral-cervical-seventh-nerve-root-cc7-transfer-in-patients-with-brachial-plexus-injuries
#12
Ryosuke Kakinoki, Scott F M Duncan, Ryosuke Ikeguchi, Souichi Ohta, Manabu Nankaku, Hiroshi Sakai, Takashi Noguchi, Yukitoshi Kaizawa, Masao Akagi
BACKGROUND: Previous animal studies demonstrated that the sensory and motor functions in ipsilesional upper limbs that had been reconstructed by CC7 transfer eventually associated with the contralesional brain cortices that had originally mediated the functions of the ipsilesional upper limbs before brachial plexus injury (BPI). Our hypothesis was that the same findings would be seen in humans. METHODS: Four patients with total BPI treated with CC7 transfer were included...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28501137/supinator-to-ulnar-nerve-transfer-via-in-situ-anterior-interosseous-nerve-bridge-to-restore-intrinsic-muscle-function-in-combined-proximal-median-and-ulnar-nerve-injury-a-novel-cadaveric-study
#13
Hamid Namazi, Shahin HajiVandi
BACKGROUND: In cases of high ulnar nerve palsy, result of nerve repair in term of intrinsic muscle recovery is unsatisfactory. Distal nerve transfer can diminish the regeneration time and improve the results. But, there was no perfect distal nerve transfer for restoring intrinsic hand function in combined proximal median and ulnar nerve injuries. This cadaveric study aims to evaluate the possibility and feasibility of supinator nerve transfer to motor branch of ulnar nerve (MUN). METHODS: Ten cadaveric upper limbs dissected to identify the location of the supinator branch, anterior interosseous nerve (AIN), and MUN...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28494100/paracrine-regulation-of-melanogenesis
#14
REVIEW
X H Yuan, Z H Jin
Melanocytes are generally characterized by the basic ability of melanin synthesis and transfer to adjacent keratinocytes to constitute individual skin phenotype and provide epidermal protection from various stimuli, such as ultraviolet (UV) irradiation, through a complex process called melanogenesis, which can be regulated by autocrine or paracrine factors. Recent evidences have revealed the paracrine effects of keratinocytes on melanogenesis by secreting cytokines, including alpha-melanocyte stimulating hormone (α-MSH) and endothelin-1...
May 11, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28490272/transfer-of-the-musculocutaneous-nerve-branch-to-the-brachialis-muscle-to-the-triceps-for-elbow-extension-anatomical-study-and-report-of-five-cases
#15
J A Bertelli, F Soldado, M F Ghizoni, A Rodríguez-Baeza
We report the study of the anatomical feasibility of transferring the nerve to the brachialis muscle to the upper medial head motor branch that innervate the triceps, and outcomes of such transfers in restoring elbow extension in five patients with posterior cord lesion of the brachial plexus. The length of the branches to the brachialis muscle measured 7.6 cm and the triceps upper medial head motor branch was 5 cm in 10 adult cadavers. Five male patients were treated with this transfer 5 months after the injury (range 4 to 6 months) after posterior cord injury of the brachial plexus with a mean follow-up of 31 months (range 28 to 36 months)...
February 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28489810/a-case-report-of-hereditary-neuropathy-with-liability-to-pressure-palsies-accompanied-by-type-2-diabetes-mellitus-and-psoriasis
#16
Jing Li, Bing Niu, Xiaoling Wang, Huaiqiang Hu, Bingzhen Cao
RATIONALE: Hereditary neuropathy with liability to pressure palsy (HNPP) is an episodic, multifocal neuropathy, with a typical clinical presentation of recurrent transient pressure palsies, which is induced by a PMP22 deletion. Another neuropathy caused by a PMP22 duplication is Charcot-Marie-Tooth disease type 1A (CMT1A). PMP22 is a gene coding a protein called peripheral myelin protein 22 (PMP22), which plays an essential role in the formation and maintenance of compact myelin. Coexistence of type 2 diabetes mellitus (T2DM) and CMT1A has been reported in many work, however HNPP patients with T2DM are rare, and comorbidity of HNPP and psoriasis has not been reported previously...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28489457/adverse-events-associated-with-a-large-dose-of-intravenous-lipid-emulsion-for-suspected-local-anesthetic-toxicity
#17
Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt
BACKGROUND: Intravenous lipid emulsion (ILE) has gained favor as a rescue treatment for cardiovascular collapse due to intravenous local anesthetic overdose, however, goals of ILE therapy are still being defined. We describe a case of a girl given 66 mL/kg of 20% lipid emulsion (ILE) in the treatment of presumed mepivacaine toxicity. CASE REPORT: An 11-year-old girl weighing 55.6 kg developed pallor, rolling back of the eyes, and rhythmic muscle twitching after receiving a mandibular nerve block injection with a 1...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28472009/endoscopic-corneal-neurotization-cadaver-feasibility-study
#18
Ilya Leyngold, Christopher Weller, Mark Leyngold, Edgar Espana, Kaelan D Black, Kathryn L Hall, Mark Tabor
PURPOSE: The authors describe a cadaver feasibility study investigating a minimally invasive technique for corneal neurotization with the supraorbital nerve harvested endoscopically. METHODS: A cadaver study was performed to investigate the technical feasibility of corneal neurotization via endoscopic supraorbital nerve transfer to the corneoscleral limbus. RESULTS: Endoscopic corneal neurotization was successfully performed on each cadaveric hemiface...
May 2, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28468849/musculotendon-adaptations-and-preservation-of-spinal-reflex-pathways-following-agonist-to-antagonist-tendon-transfer
#19
Mark A Lyle, T Richard Nichols, Elma Kajtaz, Huub Maas
Tendon transfer surgeries are performed to restore lost motor function, but outcomes are variable, particularly those involving agonist-to-antagonist muscles. Here, we evaluated the possibility that lack of proprioceptive feedback reorganization and musculotendon adaptations could influence outcomes. Plantaris-to-tibialis anterior tendon transfer along with resection of the distal third of the tibialis anterior muscle belly was performed in eight cats. Four cats had concurrent transection of the deep peroneal nerve...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28467619/repair-of-the-musculocutaneous-nerve-using-the-vagus-nerve-as-donor-by-helicoid-end-to-side-technique-an-experimental-study-in-rats
#20
Ji-Geng Yan, Feng-Yi Shen, Jacob Thayer, Yuhui Yan, John LoGiudice, Hani Matloub, James Sanger, Lin-Ling Zhang, Robert Havlik
Although several donor nerves can be chosen to repair avulsed brachial plexus nerve injury, available nerves are still limited. The purpose of this study is to validate whether the vagus nerve (VN) can be used as a donor. Eighteen Sprague-Dawley male rats were divided into three groups (n = 6). The right musculocutaneous nerve (McN) was transected with differing subsequent repair. (1) HS-VN group: a saphenous nerve (SN) graft-end was helicoidally wrapped round the VN side (epi-and perineurium was opened) with a 30 ° angle, distal SN end was coapted to the McN with end-to-end repair...
May 3, 2017: Journal of Neuroscience Research
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