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https://www.readbyqxmd.com/read/28638701/reinnervation-of-denervated-muscle-by-implantation-of-nerve-muscle-endplate-band-graft-to-the-native-motor-zone-of-the-target-muscle
#1
Liancai Mu, Stanislaw Sobotka, Jingming Chen, Themba Nyirenda
INTRODUCTION: Motor endplate reinnervation is critical for restoring motor function of the denervated muscle. We developed a novel surgical technique called nerve-muscle-endplate band grafting (NMEG) for muscle reinnervation. METHODS: Experimentally denervated sternomastoid muscle in the rat was reinnervated by transferring a NMEG from the ipsilateral sternohyoid muscle to the native motor zone (NMZ) of the target muscle. A NMEG pedicle contained a block of muscle (~ 6 × 6 × 3 mm), a nerve branch with axon terminals, and a motor endplate band with numerous neuromuscular junctions...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28632885/restoring-facial-symmetry-through-non-surgical-cosmetic-procedures-after-permanent-facial-paralxsis-a-case-report
#2
Ali Sahan, Funda Tamer
Facial nerve paralysis can occur due to infection, inflammation, trauma, surgery, and tumors. It leads to facial asymmetry, impaired oral competence, articulation deficits, and psychological problems. Treatment options include physical therapy, static slings, nerve and muscle transfers, blepharoplasty, brow lift, and chemodenervation with botulinum toxin. We report the case of a 66-year-old Caucasian female with permanent facial paralysis following middle ear surgery. The facial asymmetry was treated successfully with botulinum toxin A injection, hyaluronic acid dermal filler injection, and a thread-lift procedure...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28630754/nerve-injuries-of-the-upper-extremity-and-hand
#3
Lars B Dahlin, Mikael Wiberg
A nerve injury has a profound impact on the patient's daily life due to the impaired sensory and motor function, impaired dexterity, sensitivity to cold as well as eventual pain problems.To perform an appropriate treatment of nerve injuries, a correct diagnosis must be made, where the injury is properly classified, leading to an optimal surgical approach and technique, where timing of surgery is also important for the outcome.Knowledge about the nerve regeneration process, where delicate processes occur in neurons, non-neuronal cells (i...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28624267/endoscopic-robot-assisted-c7-nerve-root-retrophalangeal-transfer-from-the-contralateral-healthy-side-a-cadaver-feasibility-study
#4
C Bijon, L Chih-Sheng, D Chevallier, N Tran, F Xavier, P Liverneaux
Controlateral C7 nerve root transfer in brachial plexus palsy requires a nerve graft and large incisions. This study investigated the feasibility of transferring the right C7 to the left C7 nerve root, without a graft, via a minimally invasive retropharyngeal approach. After installation of 6 trocars of 1cm diameter in the supraclavicular space, a Da Vinci SI(®) robot was placed. After locating the right brachial plexus, the C7 root was sectioned flush with the clavicle, transferred behind the pharynx and sutured to the left C7 root severed at the foramen level...
June 14, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28623105/transfer-of-the-lateral-antebrachial-cutaneous-nerve-to-the-dorsal-branch-of-the-ulnar-nerve-without-nerve-graft-in-case-of-lower-brachial-plexus-injuries-anatomical-and-feasibility-study
#5
J Pauchot, U Assouline, S Valmary-Degano, B Constantinou, L Obert, D Lepage
In the context of lower (C8-T1) brachial plexus injury, transfer of the lateral antebrachial cutaneous nerve (LABCN) to the dorsal branch of the ulnar nerve (DBUN) with an interposed sural nerve graft has been proposed to restore sensitivity on the ulnar side of the hand. The purpose of this study was to assess the feasibility of performing this transfer directly - without interposition of a nerve graft - by intraneural dissection of the DBUN. An anatomical study was performed with 20 upper limbs from adult human cadavers...
June 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28617736/symmetry-restoration-at-rest-after-masseter-to-facial-nerve-transfer-is-it-as-efficient-as-smile-reanimation
#6
Gang Chen, Wenjin Wang, Wei Wang, Wei Ding, Xianxian Yang
BACKGROUND: Masseter-to-facial nerve transfer is a highly efficient technique for reanimating paralyzed muscle and has been reported to restore facial symmetry at rest. However, no systematic studies have been performed, and the effects of preoperative droop oral commissure on postoperative symmetry at rest have rarely been reported. METHODS: The authors retrospectively analyzed 35 patients with masseteric-facial nerve anastomosis and assessed the quality and quantity of the dynamic recovery and the oral commissure symmetry at rest...
June 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28616261/nerve-entrapment-as-a-cause-of-shoulder-pain-in-the-spinal-cord-injured-patient
#7
Catherine M Curtin, Carl-Goran Hagert, Claes Hultling, Elisabet Hagert
INTRODUCTION: Many people with chronic spinal cord injury (SCI) develop shoulder pain, which can adversely impact transfers and independence. Yet effective treatments remain elusive. CASE PRESENTATION: This report presents two patients with tetraplegia who had long-standing shoulder pain. Our exam showed muscle weakness and point tenderness, suggestive of nerve entrapments of the radial and axillary nerves in the posterior shoulder. These nerves were surgically decompressed and post-operatively the patients' pain resolved...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28615808/triceps-to-biceps-transfer-for-restoration-of-elbow-flexion-following-upper-brachial-plexus-injury
#8
Pothula Durga Prasada Rao, Rayidi Venkata Koteswara Rao, R Srikanth
INTRODUCTION: Upper brachial plexus injury in adults causes loss of elbow fl exion; when the primary nerve surgery has failed or the patient seeks treatment after 12 months of injury and pedicled muscle transfers are required. Most commonly, the latissimus dorsi or the Steindler flexorplasty is used. MATERIAL AND METHODS: We have transferred one of the heads of triceps muscle to restore the elbow flexion in such cases. In addition to return of elbow flexion, extension of elbow following surgery is retained...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28614796/%C3%AE-synuclein-in-gut-endocrine-cells-and-its-implications-for-parkinson-s-disease
#9
Rashmi Chandra, Annie Hiniker, Yien-Ming Kuo, Robert L Nussbaum, Rodger A Liddle
Parkinson's disease (PD) is a progressive neurodegenerative disease with devastating clinical manifestations. In PD, neuronal death is associated with intracellular aggregates of the neuronal protein α-synuclein known as Lewy bodies. Although the cause of sporadic PD is not well understood, abundant clinical and pathological evidence show that misfolded α-synuclein is found in enteric nerves before it appears in the brain. This suggests a model in which PD pathology originates in the gut and spreads to the central nervous system via cell-to-cell prion-like propagation, such that transfer of misfolded α-synuclein initiates misfolding of native α-synuclein in recipient cells...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28609352/comparing-the-efficacy-of-triple-nerve-transfers-with-nerve-graft-reconstruction-in-upper-trunk-obstetrical-brachial-plexus-injury
#10
Kathleen M O'Grady, Hollie A Power, Jaret L Olson, Michael J Morhart, A Robertson Harrop, M Joe Watt, K Ming Chan
BACKGROUND: Upper trunk obstetrical brachial plexus injury (OBPI) can cause profound shoulder and elbow dysfunction. Although neuroma excision with interpositional sural nerve grafting is the current gold standard, distal nerve transfers have a number of potential advantages. The goal of this study was to compare the clinical outcomes and healthcare costs between nerve grafting and distal nerve transfers in children with upper trunk OBPI. METHODS: In this prospective cohort study, children who received triple nerve transfers were followed with the Active Movement Scale (AMS) for 2 years...
June 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28607872/vascularized-fibula-based-physis-transfer-a-follow-up-study-of-longitudinal-bone-growth-and-complications
#11
Ronnie L Shammas, Yash J Avashia, Alfredo E Farjat, Anthony A Catanzano, L Scott Levin, William C Eward, Brian E Brigman, Detlev Erdmann
BACKGROUND: The vascularized free fibula epiphyseal transfer provides an option for the preservation of limb lengthening after resection of the proximal humerus in pediatric sarcoma patients. The purpose of this study was to provide a long-term follow-up of longitudinal growth patterns and outcomes after free fibula epiphyseal transfer in upper extremity reconstruction. METHODS: A retrospective review of 4 patients who underwent free fibula epiphyseal transfer after oncologic resection of the proximal humerus for osteosarcoma was performed...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28605134/impact-of-direct-epispinal-stimulation-on-bladder-and-bowel-functions-in-pigs-a-feasibility-study
#12
Thomas Guiho, Claire Delleci, Christine Azevedo-Coste, Charles Fattal, David Guiraud, Jean-Rodolphe Vignes, Luc Bauchet
AIMS: This study assesses the potential of epispinal (subdural) stimulation application in the treatment of urinary and bowel neurological disorders. Acute experiments were performed on a large animal model - the domestic pig - to develop a new methodology facilitating future results and technology transfers to human. METHODS: After rectal and bladder catheterization, four Landrace pigs (45-50 kg) underwent spinal cord surgery - that is, lumbosacral incision, laminectomy [L4-S4], dural opening and microsurgical arachnoid dissection...
June 12, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28579692/targeted-muscle-reinnervation-for-the-upper-and-lower-extremity
#13
Todd A Kuiken, Ann K Barlow, Levi Hargrove, Gregorgy A Dumanian
Myoelectric devices are controlled by electromyographic signals generated by contraction of residual muscles, which thus serve as biological amplifiers of neural control signals. Although nerves severed by amputation continue to carry motor control information intended for the missing limb, loss of muscle effectors due to amputation prevents access to this important control information. Targeted Muscle Reinnervation (TMR) was developed as a novel strategy to improve control of myoelectric upper limb prostheses...
June 2017: Techniques in Orthopaedics: TIO
https://www.readbyqxmd.com/read/28576943/polysialic-acid-regulates-sympathetic-outflow-by-facilitating-information-transfer-within-the-nucleus-of-the-solitary-tract
#14
Phillip Bokiniec, Shila Shahbazian, Stuart J McDougall, Britt A Berning, Delfine Cheng, Ida J Llewellyn-Smith, Peter Gr Burke, Simon McMullan, Martina Mühlenhoff, Herbert Hildebrandt, Filip Braet, Mark Connor, Nicolle H Packer, Ann K Goodchild
Expression of the large, extracellular glycan, polysialic acid (polySia) is restricted, in the adult, to brain regions exhibiting high levels of plasticity or remodelling, including the hippocampus, prefrontal cortex and the nucleus of the solitary tract (NTS). The NTS, located in the dorsal brainstem, receives constant viscerosensory afferent traffic as well as input from central regions controlling sympathetic nerve activity, respiration, gastrointestinal functions, hormonal release and behaviour. Our aims were to determine the ultrastructural location of polySia in the NTS and the functional effects of enzymatic removal of polySia, both in vitro and in vivo PolySia immunoreactivity was found throughout the adult rat NTS...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28574948/five-operations-that-give-the-best-results-after-brachial-plexus-injury
#15
Andrés A Maldonado, Allen T Bishop, Robert J Spinner, Alexander Y Shin
Treatment of brachial plexus injuries has slowly improved over the last 45 years. Changes in strategy, techniques, microsurgical equipment and technology have expanded the surgical options to reconstruct these life altering, highly complex injuries. The surgical armamentarium includes neurolysis, nerve repair, nerve grafting, nerve transfers, tendon transfer, muscle transfer and other soft tissue and bony procedures. In this article we have selected five surgical procedures (Oberlin's procedure, Leechavengvongs' procedure, free functional muscle transfer, radial nerve tendon transfers and C5-C6 nerve grafting in obstetrical birth palsy) that have consistently given us good results in our patients who require surgical reconstruction...
May 31, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28570440/successful-reinnervation-of-the-diaphragm-after-intercostal-to-phrenic-nerve-neurotization-in-patients-with-high-spinal-cord-injury
#16
Kulvir S Nandra, Martin Harari, Thea P Price, Patrick J Greaney, Michael S Weinstein
OBJECTIVE: Our objective in this study was to extend diaphragmatic pacing therapy to include paraplegic patients with high cervical spinal cord injuries between C3 and C5. INTRODUCTION: Diaphragmatic pacing has been used in patients experiencing ventilator-dependent respiratory failure due to spinal cord injury as a means to reduce or eliminate the need for mechanical ventilation. However, this technique relies on intact phrenic nerve function. Recently, phrenic nerve reconstruction with intercostal nerve grafting has expanded the indications for diaphragmatic pacing...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28565793/involvement-of-neuronal-pathways-in-the-protective-effects-of-hindlimb-perconditioning-during-renal-ischemia
#17
Zahra Sedaghat, Mehri Kadkhodaee, Behjat Seifi, Parisa Ahghari, Khalil Pourkhalili, Zahra Akbari, Mehdi Sadeghi
Remote ischemic perconditioning (RPEC) is a therapeutic intervention that has been demonstrated to reduce renal ischemia/reperfusion (I/R) injury. However, the underlying renal protective mechanism remains unclear. The present study hypothesized that RPEC may utilize neural pathways to transfer the protective signal from the perconditioned hindlimb to the kidney. Following a right nephrectomy, rats were randomly allocated into five groups (n=6). The sham group underwent the surgical protocol only. In all other groups, the left renal pedicle was clamped for 45 min and reperfused for 24 h...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28562372/masseteric-to-buccal-branch-nerve-transfer
#18
Sinehan B Bayrak, J David Kriet, Clinton D Humphrey
PURPOSE OF REVIEW: To review recent literature pertaining to the use of masseteric-facial nerve neurorrhaphy (MFNN) for facial reanimation in patients with facial paralysis. RECENT FINDINGS: First, MFNN effectively restores some midface tone and function, including the ability to smile. Second, use of the masseteric nerve minimizes synkinesis, dysarthria, and dysphagia that frequently occur after hypoglossal-facial nerve neurorrhaphy. Third, concurrent cable grafting to the zygomatic branch from an intact proximal facial nerve remnant - when available - can restore dynamic eye closure...
May 29, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28554986/connexin-43-is-involved-in-the-sympathetic-atrial-fibrillation-in-canine-and-canine-atrial-myocytes
#19
Chenglin Shu, Weiqiang Huang, Zhiyu Zeng, Yan He, Beibei Luo, Hao Liu, Jinyi Li, Jian Xu
OBJECTIVE: Atrial fibrillation (AF) is the most common rapid cardiac arrhythmia associated with high morbidity and mortality. Stimulation of the sympathetic nerve is involved in AF occurrence. The gap junction protein connexin 43 (Cx43) plays a key role in electrical conduction velocity in cardiac tissues, and under expression of Cx43 was linked with AF. The aim of this study was to investigate whether Cx43 was involved in sympathetic AF. METHODS: Fifteen dogs were randomly divided into 3 groups (5 in each group)...
May 24, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28553852/an-anatomical-study-of-additional-radial-wrist-extensors-including-a-unique-extensor-carpi-radialis-accessorius
#20
Charles Timothy West, David Ricketts, Cecilia Brassett
BACKGROUND: In this study, 82 forearms from 41 cadavers were dissected to establish the incidence of variant additional radial wrist extensors. Three variants have been described in the literature: extensor carpi radialis intermedius (ECRI), extensor carpi radialis accessorius (ECRA) and extensor carpi radialis tertius (ECRT). MATERIALS AND METHODS: Of the 41 cadavers studied, 5/41 (12%) had an additional radial wrist extensor. Of these 5 individuals, 2 had bilateral additional muscles and 3 were unilateral...
May 29, 2017: Folia Morphologica (Warsz)
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