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https://www.readbyqxmd.com/read/28718992/melatonin-impedes-tet1-dependent-mglur5-promoter-demethylation-to-relieve-pain
#1
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Dylan Chou, Hsueh-Hsiao Wang, Gin-Den Chen, Tzer-Bin Lin, Hsien-Yu Peng
Melatonin (N-acetyl-5-methoxytryptamine)/MT2 receptor-dependent epigenetic modification represents a novel pathway in the treatment of neuropathic pain. Because spinal ten-eleven translocation methylcytosine dioxygenase 1 (Tet1)-dependent epigenetic demethylation has recently been linked to pain hypersensitivity, we hypothesized that melatonin/MT2-dependent analgesia involves spinal Tet1-dependent demethylation. Here, we showed that spinal Tet1 gene transfer by intrathecal delivery of Tet1-encoding vectors to naïve rats produced profound and long-lasting nociceptive hypersensitivity...
July 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28702389/correlation-between-the-elbow-flexion-and-the-hand-and-wrist-flexion-after-neurotization-of-the-fascicles-of-the-ulnar-nerve-to-the-motor-branch-to-the-biceps
#2
Ricardo Boso Escudero, Marcelo Rosa de Rezende, Erick Yoshio Wataya, Fernando Vicente de Pontes, Álvaro Baik Cho, Marina Justi Pisani
OBJECTIVE: Gain in elbow flexion in patients with brachial plexus injury is extremely important. The transfer of a fascicle from the ulnar nerve to the motor branch of the musculocutaneous nerve (Oberlin surgery) is a treatment option. However, in some patients, gain in elbow flexion is associated with wrist and finger flexion. This study aimed to assess the frequency of this association and the functional behavior of the limb. METHODS: Case-control study of 18 patients who underwent the Oberlin surgery...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28699404/improved-external-rotation-with-concomitant-reverse-total-shoulder-arthroplasty-and-latissimus-dorsi-tendon-transfer-a-systematic-review
#3
Aaron Wey, John C Dunn, Nicholas Kusnezov, Brian R Waterman, Kelly G Kilcoyne
BACKGROUND: In conjunction with reverse total shoulder arthroplasty (RSA), latissimus dorsi and teres major (LD-TM) transfer has been advocated in the setting of combined loss of elevation and external rotation. The purpose of this systematic review is to summarize the clinical outcomes following RSA with LD-TM transfer. METHODS: A search of PubMed, EMBASE, CINAHL, Medline, and Cochrane databases was performed between January 1, 1990 and March 1, 2016 and included articles related to outcomes following RSA with LD-TM transfer...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28698257/brain-transforming-growth-factor-%C3%AE-resists-hypertension-via-regulating-microglial-activation
#4
You Li, Xiao Z Shen, Liang Li, Tuantuan V Zhao, Kenneth E Bernstein, Alan K Johnson, Patrick Lyden, Jianmin Fang, Peng Shi
BACKGROUND AND PURPOSE: Hypertension is the major risk factor for stroke. Recent work unveiled that hypertension is associated with chronic neuroinflammation; microglia are the major players in neuroinflammation, and the activated microglia elevate sympathetic nerve activity and blood pressure. This study is to understand how brain homeostasis is kept from hypertensive disturbance and microglial activation at the onset of hypertension. METHODS: Hypertension was induced by subcutaneous delivery of angiotensin II, and blood pressure was monitored in conscious animals...
July 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28688935/indirect-transfer-of-the-sternal-head-of-the-pectoralis-major-with-autogenous-semitendinosus-augmentation-to-treat-scapular-winging-secondary-to-long-thoracic-nerve-palsy
#5
Tao Li, Ze Z Yang, Yuan Deng, Ming Xiao, Chuan Jiang, Jin W Wang
BACKGROUND: Scapular winging resulting from long thoracic nerve palsy is uncommon but debilitating, and the choice of surgical treatment is inconsistent. The autogenous semitendinosus tendon plays a key role as an interposed tendon graft, although its use in the indirect transfer of the sternal head of the pectoralis major during the treatment of scapular winging has rarely been reported. MATERIALS AND METHODS: A retrospective review was performed during a 9-year period from the clinical data of 26 cases (28 shoulders) with indirect transfer of the sternal head of the pectoralis major with the interposition of an autogenous semitendinosus tendon graft for dynamic stabilization of the scapula...
July 5, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28684285/a-higher-quality-of-life-with-cross-face-nerve-grafting-as-an-adjunct-to-a-hypoglossal-facial-nerve-jump-graft-in-facial-palsy-treatment
#6
Martinus M van Veen, Pieter U Dijkstra, Paul M N Werker
Nerve reconstructions are the preferred technique for short-standing facial paralysis, most commonly using the contralateral facial nerve or ipsilateral hypoglossal nerve. The hypoglossal nerve provides a strong motor signal, whereas the signal of a cross-face nerve graft is weaker but spontaneous. Spontaneity in facial expression is believed to be important for psychological wellbeing. Therefore, a combination of the two procedures incorporates the best of both: a strong motor signal and a spontaneous smile...
June 10, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28669300/contralateral-c-7-transfer-is-direct-repair-really-superior-to-grafting
#7
Anil Bhatia, Piyush Doshi, Ashok Koul, Vitrag Shah, Justin M Brown, Mahmoud Salama
It is not uncommon for a severe traumatic brachial plexus injury to involve all 5 roots, resulting in a flail upper limb. In such cases, surgical reconstruction is often palliative, providing only rudimentary function. Nerve transfers are the mainstay of reconstructive strategies due to the predominance of root avulsions. Consistent results are obtained only for restoration of shoulder stability and elbow flexion, whereas restoring useful hand function remains a challenge. The transfer of the contralateral C-7 (cC-7) is commonly used in an attempt to restore basic hand function, but results are notoriously unreliable and inconsistent...
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28669296/a-neurophysiological-approach-to-nerve-transfer-to-restore-upper-limb-function-in-cervical-spinal-cord-injury
#8
Ross M Mandeville, Justin M Brown, Geoffrey L Sheean
A successful nerve transfer surgery can provide a wealth of benefits to a patient with cervical spinal cord injury. The process of surgical decision making ideally uses all pertinent information to produce the best functional outcome. Reliance on clinical examination and imaging studies alone can miss valuable information on the state of spinal cord health. In this regard, neurophysiological evaluation has the potential to effectively gauge the neurological status of even select pools of anterior horn cells and their axons to small nerve branches in question to determine the potential efficacy of their use in a transfer...
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28669295/nerve-transfer-versus-muscle-transfer-to-restore-elbow-flexion-after-pan-brachial-plexus-injury-a-cost-effectiveness-analysis
#9
Arvin R Wali, David R Santiago-Dieppa, Justin M Brown, Ross Mandeville
OBJECTIVE Pan-brachial plexus injury (PBPI), involving C5-T1, disproportionately affects young males, causing lifelong disability and decreased quality of life. The restoration of elbow flexion remains a surgical priority for these patients. Within the first 6 months of injury, transfer of spinal accessory nerve (SAN) fascicles via a sural nerve graft or intercostal nerve (ICN) fascicles to the musculocutaneous nerve can restore elbow flexion. Beyond 1 year, free-functioning muscle transplantation (FFMT) of the gracilis muscle can be used to restore elbow flexion...
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28667708/acute-painful-autoimmune-neuropathy-a-variant-of-guillain-barr%C3%A3-syndrome
#10
Nobuhiro Yuki, Amanda C Chan, Anna Hiu Yi Wong, Takayuki Inoue, Masafumi Yokai, Takashi Kurihara, Jérôme J Devaux, Einar Wilder-Smith
Introduction We present a painful small fibre neuropathy variant of Guillain-Barré syndrome. Methods characterized by antecedent infectious symptoms, hyporeflexia and albuminocytologic dissociation. Results Two patients received intravenous immunoglobulin, and subsequently improved. IgG antibodies in their acute phase sera strongly bound to murine small nerve fibres, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses...
July 1, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28666151/triceps-nerve-to-deltoid-nerve-transfer-after-an-unsatisfactory-intra-plexus-neurotization-of-the-posterior-division-of-the-upper-trunk
#11
Mohammad M Al-Qattan, Abdullah E Kattan, Bayan S Al-Qahtany, Omar M Al-Qattan, Heba M Al-Qattan
INTRODUCTION: Our literature review did not reveal any study on the results of triceps to deltoid nerve transfer done as a secondary procedure after an unsatisfactory primary intraplexus neurotization of the posterior division of the upper trunk. PRESENTATION OF CASES: We report on three adults with C5-C6 brachial plexus injury who had an unsatisfactory deltoid function following primary intraplexus neurotization. Patients presented to our clinic late (14-16 months after injury)...
June 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28647810/distal-nerve-transfer-versus-supraclavicular-nerve-grafting-comparison-of-elbow-flexion-outcome-in-neonatal-brachial-plexus-palsy-with-c5-c7-involvement
#12
Carlos O Heise, Mario G Siqueira, Roberto S Martins, Luciano H Foroni, Hugo Sterman-Neto
PURPOSE: Ulnar and median nerve transfers to arm muscles have been used to recover elbow flexion in infants with neonatal brachial plexus palsy, but there is no direct outcome comparison with the classical supraclavicular nerve grafting approach. METHODS: We retrospectively analyzed patients with C5-C7 neonatal brachial plexus palsy submitted to nerve surgery and recorded elbow flexion recovery using the active movement scale (0-7) at 12 and 24 months after surgery...
June 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28638701/reinnervation-of-denervated-muscle-by-implantation-of-nerve-muscle-endplate-band-graft-to-the-native-motor-zone-of-the-target-muscle
#13
Liancai Mu, Stanislaw Sobotka, Jingming Chen, Themba Nyirenda
INTRODUCTION: Motor endplate reinnervation is critical for restoring motor function of the denervated muscle. We developed a novel surgical technique called nerve-muscle-endplate band grafting (NMEG) for muscle reinnervation. METHODS: Experimentally denervated sternomastoid muscle in the rat was reinnervated by transferring a NMEG from the ipsilateral sternohyoid muscle to the native motor zone (NMZ) of the target muscle. A NMEG pedicle contained a block of muscle (~ 6 × 6 × 3 mm), a nerve branch with axon terminals, and a motor endplate band with numerous neuromuscular junctions...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28632885/restoring-facial-symmetry-through-non-surgical-cosmetic-procedures-after-permanent-facial-paralysis-a-case-report
#14
Ali Sahan, Funda Tamer
Facial nerve paralysis can occur due to infection, inflammation, trauma, surgery, and tumors. It leads to facial asymmetry, impaired oral competence, articulation deficits, and psychological problems. Treatment options include physical therapy, static slings, nerve and muscle transfers, blepharoplasty, brow lift, and chemodenervation with botulinum toxin. We report the case of a 66-year-old Caucasian female with permanent facial paralysis following middle ear surgery. The facial asymmetry was treated successfully with botulinum toxin A injection, hyaluronic acid dermal filler injection, and a thread-lift procedure...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28630754/nerve-injuries-of-the-upper-extremity-and-hand
#15
Lars B Dahlin, Mikael Wiberg
A nerve injury has a profound impact on the patient's daily life due to the impaired sensory and motor function, impaired dexterity, sensitivity to cold as well as eventual pain problems.To perform an appropriate treatment of nerve injuries, a correct diagnosis must be made, where the injury is properly classified, leading to an optimal surgical approach and technique, where timing of surgery is also important for the outcome.Knowledge about the nerve regeneration process, where delicate processes occur in neurons, non-neuronal cells (i...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28624267/endoscopic-robot-assisted-c7-nerve-root-retrophalangeal-transfer-from-the-contralateral-healthy-side-a-cadaver-feasibility-study
#16
C Bijon, L Chih-Sheng, D Chevallier, N Tran, F Xavier, P Liverneaux
Controlateral C7 nerve root transfer in brachial plexus palsy requires a nerve graft and large incisions. This study investigated the feasibility of transferring the right C7 to the left C7 nerve root, without a graft, via a minimally invasive retropharyngeal approach. After installation of 6 trocars of 1cm diameter in the supraclavicular space, a Da Vinci SI(®) robot was placed. After locating the right brachial plexus, the C7 root was sectioned flush with the clavicle, transferred behind the pharynx and sutured to the left C7 root severed at the foramen level...
June 14, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/28623105/transfer-of-the-lateral-antebrachial-cutaneous-nerve-to-the-dorsal-branch-of-the-ulnar-nerve-without-nerve-graft-in-case-of-lower-brachial-plexus-injuries-anatomical-and-feasibility-study
#17
J Pauchot, U Assouline, S Valmary-Degano, B Constantinou, L Obert, D Lepage
In the context of lower (C8-T1) brachial plexus injury, transfer of the lateral antebrachial cutaneous nerve (LABCN) to the dorsal branch of the ulnar nerve (DBUN) with an interposed sural nerve graft has been proposed to restore sensitivity on the ulnar side of the hand. The purpose of this study was to assess the feasibility of performing this transfer directly - without interposition of a nerve graft - by intraneural dissection of the DBUN. An anatomical study was performed with 20 upper limbs from adult human cadavers...
June 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28617736/symmetry-restoration-at-rest-after-masseter-to-facial-nerve-transfer-is-it-as-efficient-as-smile-reanimation
#18
Gang Chen, Wenjin Wang, Wei Wang, Wei Ding, Xianxian Yang
BACKGROUND: Masseter-to-facial nerve transfer is a highly efficient technique for reanimating paralyzed muscle and has been reported to restore facial symmetry at rest. However, no systematic studies have been performed, and the effects of preoperative droop oral commissure on postoperative symmetry at rest have rarely been reported. METHODS: The authors retrospectively analyzed 35 patients with masseteric-facial nerve anastomosis and assessed the quality and quantity of the dynamic recovery and the oral commissure symmetry at rest...
June 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28616261/nerve-entrapment-as-a-cause-of-shoulder-pain-in-the-spinal-cord-injured-patient
#19
Catherine M Curtin, Carl-Goran Hagert, Claes Hultling, Elisabet Hagert
INTRODUCTION: Many people with chronic spinal cord injury (SCI) develop shoulder pain, which can adversely impact transfers and independence. Yet effective treatments remain elusive. CASE PRESENTATION: This report presents two patients with tetraplegia who had long-standing shoulder pain. Our exam showed muscle weakness and point tenderness, suggestive of nerve entrapments of the radial and axillary nerves in the posterior shoulder. These nerves were surgically decompressed and post-operatively the patients' pain resolved...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28615808/triceps-to-biceps-transfer-for-restoration-of-elbow-flexion-following-upper-brachial-plexus-injury
#20
Pothula Durga Prasada Rao, Rayidi Venkata Koteswara Rao, R Srikanth
INTRODUCTION: Upper brachial plexus injury in adults causes loss of elbow fl exion; when the primary nerve surgery has failed or the patient seeks treatment after 12 months of injury and pedicled muscle transfers are required. Most commonly, the latissimus dorsi or the Steindler flexorplasty is used. MATERIAL AND METHODS: We have transferred one of the heads of triceps muscle to restore the elbow flexion in such cases. In addition to return of elbow flexion, extension of elbow following surgery is retained...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
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