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https://www.readbyqxmd.com/read/28607099/inhibition-of-the-host-cell-lysosome-spreading-by-trypanosoma-cruzi-metacyclic-stage-specific-surface-molecule-gp90-down-regulates-parasite-invasion
#1
João Paulo Ferreira Rodrigues, Guilherme Hideki Takahashi Sant'ana, Maria Aparecida Juliano, Nobuko Yoshida
Successful infection by Trypanosoma cruzi, the agent of Chagas disease, is critically dependent on the host cell invasion by metacyclic trypomastigote (MT) forms. Two main metacyclic stage-specfic surface molecules, gp82 and gp90, play determinant roles in target cell invasion in vitro and in oral T. cruzi infection in mice. The structure and properties of gp82, which is highly conserved among T. cruzi strains, are well known. Informations on gp90 are still rather sparse. Here we attempted to fill that gap...
June 12, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28536686/mandible-metastasis-of-small-cell-lung-cancer-mimicking-a-residual-cyst
#2
Renata Mendonça Moraes, Fabio Abreu Alves, Bruna Fernandes do Carmo Carvalho, Felipe D'Almeida Costa, Rodrigo Nascimento Lopes, Graziella Chagas Jaguar
Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction...
January 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28527286/-possible-oral-transmission-of-chagas-disease-among-hydrocarbons-sector-workers-in-casanare-colombia-2014
#3
Liliana Patricia Zuleta-Dueñas, Ángela Johana López-Quiroga, Fernando Torres-Torres, Oneida Castañeda-Porras
INTRODUCTION: Trypanosoma cruzi, the etiological agent for Chagas disease, can be transmitted by oral intake of contaminated food or drinks. During epidemiological week 14 of 2014, two cases of acute Chagas disease were notified among hydrocarbons sector workers in Paz de Ariporo, Casanare. OBJECTIVE: To characterize the affected population, to establish control and prevention measures and to confirm the outbreak. MATERIALS AND METHODS: We conducted an outbreak investigation that included the following components: a) Search for symptomatic people compatible with Chagas disease according to the case definition for their referral to medical services; b) entomological survey (192/197 houses); c) sanitary inspection and microbiological analysis of food samples; and d) study of reservoirs...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28512727/variability-of-high-dose-melphalan-exposure-on-oral-mucositis-in-patients-undergoing-prophylactic-low-level-laser-therapy
#4
Gustavo Henrique Rodrigues, Graziella Chagas Jaguar, Fabio Abreu Alves, Andre Guollo, Vanessa Oliveira Camandoni, Aline Santos Damascena, Vladmir Claudio Cordeiro Lima
The present study outlines the clinical impact and risk factors of oral mucositis in 79 patients with multiple myeloma following high-dose melphalan for autologous transplant. All patients underwent daily prophylactic low-level indium gallium aluminum phosphate diode laser therapy (660 nm, 15 mW, 3.75 J/cm(2), 10 s per point) from the beginning of the conditioning regimen up to day +2. Oral mucositis assessments were made daily until hospital discharge. For analysis, oral mucositis was divided into two groups according to severity: group 1, patients with oral mucositis grade <III (n = 71) and group 2, patients with oral mucositis grade ≥III (n = 8)...
May 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28506517/fish-oil-supplementation-benefits-the-murine-host-during-the-acute-phase-of-a-parasitic-infection-from-trypanosoma-cruzi
#5
Maria I Lovo-Martins, Aparecida D Malvezi, Rosiane V da Silva, Nágela G Zanluqui, Vera L H Tatakihara, Niels O S Câmara, Ana Paula L de Oliveira, Jean P S Peron, Marli C Martins-Pinge, Kevin L Fritsche, Phileno Pinge-Filho
Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are known to modulate a variety of immune cell functions. On occasion, this has led to diminished host resistance to certain viral and bacterial infections. Little is known about the impact of n-3 PUFA on host resistance to parasitic infection, however, based on results from a small study conducted more than two decades ago, we hypothesized that providing mice LC n-3 PUFA will diminish host resistance to Trypanosoma cruzi, the parasitic pathogen responsible for Chagas disease...
May 2017: Nutrition Research
https://www.readbyqxmd.com/read/28379959/unraveling-chagas-disease-transmission-through-the-oral-route-gateways-to-trypanosoma-cruzi-infection-and-target-tissues
#6
Danielle Silva-Dos-Santos, Juliana Barreto-de-Albuquerque, Bárbara Guerra, Otacilio C Moreira, Luiz Ricardo Berbert, Mariana Tavares Ramos, Barbara Angelica S Mascarenhas, Constança Britto, Alexandre Morrot, Déa M Serra Villa-Verde, Luciana Ribeiro Garzoni, Wilson Savino, Vinícius Cotta-de-Almeida, Juliana de Meis
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice. However, it remains uncertain the primary site of parasite entry and multiplication due to an oral infection. Here, we evaluated the presence of T...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28374923/oral-fish-oil-positively-influences-nutritional-inflammatory-risk-in-patients-with-haematological-malignancies-during-chemotherapy-with-an-impact-on-long-term-survival-a-randomised-clinical-trial
#7
T R Chagas, D S Borges, P F de Oliveira, M C Mocellin, A M Barbosa, C Q Camargo, J Â G Del Moral, A Poli, P C Calder, E B S M Trindade, E A Nunes
BACKGROUND: Studies suggest that the ingestion of fish oil (FO), a source of the omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), can reduce the deleterious side-effects of chemotherapy. The aim of this randomised clinical trial was to evaluate the effect of supplementation with oral FO for 9 weeks on nutritional parameters and inflammatory nutritional risk in patients with haematological malignancies during the beginning of chemotherapy...
April 4, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28274885/molecular-identification-of-wild-triatomines-of-the-genus-rhodnius-in-the-bolivian-amazon-strategy-and-current-difficulties
#8
Simone Frédérique Brenière, Edwin Wily Condori, Rosio Buitrago, Luis Fernando Sosa, Catarina Lopes Macedo, Christian Barnabé
The Amazon region has recently been considered as endemic in Latin America. In Bolivia, the vast Amazon region is undergoing considerable human migrations and substantial anthropization of the environment, potentially renewing the danger of establishing the transmission of Chagas disease. The cases of human oral contamination occurring in 2010 in the town of Guayaramerín provided reasons to intensify research. As a result, the goal of this study was to characterize the species of sylvatic triatomines circulating in the surroundings of Yucumo (Beni, Bolivia), a small Amazonian city at the foot of the Andes between the capital (La Paz) and Trinidad the largest city of Beni...
March 6, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28250661/antifungal-activity-of-hydroalcoholic-extract-of-chrysobalanus-icaco-against-oral-clinical-isolates-of-candida-species
#9
João Paulo Bastos Silva, Ana Regina Maués Noronha Peres, Thiago Portal Paixão, Andressa Santa Brígida Silva, Ana Cristina Baetas, Wagner Luiz Ramos Barbosa, Marta Chagas Monteiro, Marcieni Ataíde Andrade
BACKGROUND: Chrysobalanus icaco is a medicinal plant commonly used to treat fungal infections in Brazilian Amazonian region. OBJECTIVE: This work aimed to evaluate the antifungal activity of the hydroalcoholic extract of C. icaco (HECi) against oral clinical isolates of Candida spp. and to determine the pharmacognostic parameters of the herbal drug and the phytochemical characteristics of HECi. MATERIALS AND METHODS: The pharmacognostic characterization was performed using pharmacopoeial techniques...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28198632/engineering-oral-and-parenteral-amorphous-amphotericin-b-formulations-against-experimental-trypanosoma-cruzi-infections
#10
Miriam Rolón, Dolores R Serrano, Aikaterini Lalatsa, Esther de Pablo, Juan Jose Torrado, Maria Paloma Ballesteros, Anne Marie Healy, Celeste Vega, Cathia Coronel, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela
Chagas disease (CD) is a parasitic zoonosis endemic in most mainland countries of Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease. Treatment is only effective if received at the early stages of the disease. Only two drugs (benznidazole and nifurtimox) have so far been marketed, and both share various limitations such as variable efficacy, many side effects, and long duration of treatment, thus reducing compliance. The in vitro and in vivo efficacy of poly-aggregated amphotericin B (AmB), encapsulated poly-aggregated AmB in albumin microspheres (AmB-AME), and dimeric AmB-sodium deoxycholate micelles (AmB-NaDC) was evaluated...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28167558/pharmacokinetics-and-tissue-distribution-of-benznidazole-after-oral-administration-in-mice
#11
Luísa Perin, Rodrigo Moreira da Silva, Kátia da Silva Fonseca, Jamille Mirelle de Oliveira Cardoso, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Israel Molina, Rodrigo Correa-Oliveira, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro
Specific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical high-performance liquid chromatography method with a UV detector (HPLC-UV) was developed and validated according to the European Medicines Agency for quantification of BNZ in organs and plasma samples prepared by liquid-liquid extraction using ethyl acetate...
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28146169/chagas-disease-transmission-by-consumption-of-game-meat-systematic-review
#12
Luiz Henrique Conde Sangenis, Marco Antonio Prates Nielebock, Ceumara da Silva Santos, Mateus Curty Carriello da Silva, Glauber Motta Ribeiro Bento
Objective: To evaluate the influence of game meat consumption in Chagas disease (CD) transmission, the conditions under which it occurs and the frequency of reports in the literature. Methods: Through systematic review, databases PubMed, LILACS, MEDLINE, and SciELO were consulted, and articles written in Portuguese, English, and Spanish were included, with no limitation over publication date. We used the following descriptors: oral, transmission, meat, wild animals, hunt, carnivory, and Chagas disease...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28132566/long-term-comparative-pharmacovigilance-of-orally-transmitted-chagas-disease-first-report
#13
Belkisyolé Alarcón de Noya, Raiza Ruiz-Guevara, Oscar Noya, Julio Castro, John Ossenkopp, Zoraida Díaz-Bello, Cecilia Colmenares, José Antonio Suárez, Oscar Noya-Alarcón, Laura Naranjo, Humberto Gutiérrez, Giuseppa Quinci, Jaime Torres
BACKGROUND: Two old drugs are the only choice against Trypanosoma cruzi and little is known about their secondary effects in the acute stage of oral-transmitted Chagas disease (ChD). METHODS: A cross-sectional analytical surveillance study was conducted in a sizable cohort of patients seen during the largest acute foodborne ChD microepidemic registered so far. Individuals were treated with benznidazole (BNZ) or nifurtimox (NFX). 'Common Terminology Criteria for Adverse Events' was assessed to categorize side effects according to severity...
March 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28108369/jaburetox-affects-gene-expression-and-enzyme-activities-in-rhodnius-prolixus-a-chagas-disease-vector
#14
Leonardo L Fruttero, Natalia R Moyetta, Monique Siebra Krug, Valquiria Broll, Matheus V Coste Grahl, Rafael Real-Guerra, Fernanda Stanisçuaski, Celia R Carlini
Jaburetox, a recombinant peptide of ∼11kDa derived from one of the Canavalia ensiformis (Jack Bean) urease isoforms, is toxic and lethal to insects belonging to different orders when administered orally or via injection. Previous findings indicated that Jaburetox acts on insects in a complex fashion, inhibiting diuresis and the transmembrane potential of Malpighian tubules, interfering with muscle contractility and affecting the immune system. In vitro, Jaburetox forms ionic channels and alters permeability of artificial lipid membranes...
January 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28025938/trypanothione-reductase-and-superoxide-dismutase-as-current-drug-targets-for-trypanosoma-cruzi-an-overview-of-compounds-with-activity-against-chagas-disease
#15
Iván Beltrán-Hortelano, Silvia Pérez-Silanes, Silvia Galiano
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi) as the causative agent of Chagas disease (CD), a neglected tropical disease with several socioeconomic, epidemiological and human health repercussions. Currently, there are only two commercialized drugs to treat CD in acute phase, nifurtimox and benznidazol, with several adverse side effects. Thus, new orally available and safe drugs for this parasitic infection are urgently required. One strategy of great importance in new drug discovery programmes is based on the search of molecules enabling to interfere with enzymes involved in T...
December 26, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27993415/orally-transmitted-chagas-disease
#16
REVIEW
Maria Teresa Filigheddu, Miguel Górgolas, José Manuel Ramos
Chagas disease is a zoonosis caused by protozoan parasite Trypanosoma cruzi, which is most frequently associated with a vectorial transmission. However, in recent years we have observed a significant increase in the oral transmission of the disease, associated mainly with the consumption of drinks made from fruit or other vegetables contaminated with triatomine faeces or secretions from infected mammals. After a latency period of 3 to 22 days after ingestion, the oral infection is characterized by more severe manifestations than those associated with vectorial transmission: prolonged fever, acute myocarditis with heart failure and, in some cases, meningoencephalitis...
February 9, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27876646/outcome-of-oral-infection-in-mice-inoculated-with-trypanosoma-cruzi-iv-of-the-western-brazilian-amazon
#17
Ana Paula Margioto Teston, Ana Paula de Abreu, Camila Piva Abegg, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo
A new epidemiological view of American trypanosomiasis or Chagas disease has been formulated in recent decades. Oral transmission of the etiological agent of Chagas disease, Trypanosoma cruzi, has been the most common form of transmission. The T. cruzi discrete typing units TcI and TcIV have been involved in tens outbreaks of acute cases of Chagas disease in the Brazilian Amazon region. We investigated the intensity of infection in mice that were orally inoculated (OR group) with four strains of TcIV that were isolated from two outbreaks of acute Chagas disease that was orally acquired in the state of Amazonas, Brazil...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27758973/evolution-of-chagas-disease-in-brazil-epidemiological-perspective-and-challenges-for-the-future-a-critical-review
#18
Rafael Bello Corassa, Carmen Aceijas, Paula Aryane Brito Alves, Hemda Garelick
AIMS: This article aimed to provide a critical review of the evolution of Chagas' disease (ChD) in Brazil, its magnitude, historical development and management, and challenges for the future. METHODS: A literature search was performed using PubMed, SciELO and Google Scholar and throughout collected articles' references. Narrative analysis was structured around five main themes identified: vector transmission, control programme, transfusion, oral and congenital transmission...
October 10, 2016: Perspectives in Public Health
https://www.readbyqxmd.com/read/27679947/single-transverse-extended-incision-for-radical-neck-dissection
#19
José Francisco Sales Chagas, Maria Beatriz Nogueira Pascoal, José Luís Braga Aquino, Luís Antônio Brandi, Evandro Von Zuben Previtale, Ana Sofia Pontes Trillo, Otávio Alberto Curioni, Abrão Rapoport, Rogério Aparecido Dedivitis
OBJECTIVE: to assess the efficacy of the single transverse extended cervical incision in radical neck dissection. METHOD: we conducted a prospective study, from January 2008 to January 2009, with 18 patients undergoing surgical treatment of malignant tumors of the upper aero-digestive tract. The primary lesion was located in the oral cavity in eight cases, in the oropharynx in three, in the hypopharynx in three, in the larynx in two, in the maxillary sinus, and in one case, the primary injury was hidden...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27627643/chronic-heart-disease-after-treatment-of-oral-acute-chagas-disease
#20
Andrei Fornanciari Antunes, Simão Gonçalves Maduro, Bruna Valessa Moutinho Pereira, Maria das Graças Vale Barbosa, Jorge Augusto de Oliveira Guerra, João Marcos Bemfica Barbosa Ferreira
We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years.
August 2016: Arquivos Brasileiros de Cardiologia
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