keyword
MENU ▼
Read by QxMD icon Read
search

Oral chagas

keyword
https://www.readbyqxmd.com/read/27876646/outcome-of-oral-infection-in-mice-inoculated-with-trypanosoma-cruzi-iv-of-the-western-brazilian-amazon
#1
Ana Paula Margioto Teston, Ana Paula de Abreu, Camila Piva Abegg, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo
A new epidemiological view of American trypanosomiasis or Chagas disease has been formulated in recent decades. Oral transmission of the etiological agent of Chagas disease, Trypanosoma cruzi, has been the most common form of transmission. The T. cruzi discrete typing units TcI and TcIV have been involved in tens outbreaks of acute cases of Chagas disease in the Brazilian Amazon region. We investigated the intensity of infection in mice that were orally inoculated (OR group) with four strains of TcIV that were isolated from two outbreaks of acute Chagas disease that was orally acquired in the state of Amazonas, Brazil...
November 19, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27758973/evolution-of-chagas-disease-in-brazil-epidemiological-perspective-and-challenges-for-the-future-a-critical-review
#2
Rafael Bello Corassa, Carmen Aceijas, Paula Aryane Brito Alves, Hemda Garelick
AIMS: This article aimed to provide a critical review of the evolution of Chagas' disease (ChD) in Brazil, its magnitude, historical development and management, and challenges for the future. METHODS: A literature search was performed using PubMed, SciELO and Google Scholar and throughout collected articles' references. Narrative analysis was structured around five main themes identified: vector transmission, control programme, transfusion, oral and congenital transmission...
October 10, 2016: Perspectives in Public Health
https://www.readbyqxmd.com/read/27679947/single-transverse-extended-incision-for-radical-neck-dissection
#3
José Francisco Sales Chagas, Maria Beatriz Nogueira Pascoal, José Luís Braga Aquino, Luís Antônio Brandi, Evandro Von Zuben Previtale, Ana Sofia Pontes Trillo, Otávio Alberto Curioni, Abrão Rapoport, Rogério Aparecido Dedivitis
OBJECTIVE: to assess the efficacy of the single transverse extended cervical incision in radical neck dissection. METHOD: we conducted a prospective study, from January 2008 to January 2009, with 18 patients undergoing surgical treatment of malignant tumors of the upper aero-digestive tract. The primary lesion was located in the oral cavity in eight cases, in the oropharynx in three, in the hypopharynx in three, in the larynx in two, in the maxillary sinus, and in one case, the primary injury was hidden...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27627643/chronic-heart-disease-after-treatment-of-oral-acute-chagas-disease
#4
Andrei Fornanciari Antunes, Simão Gonçalves Maduro, Bruna Valessa Moutinho Pereira, Maria das Graças Vale Barbosa, Jorge Augusto de Oliveira Guerra, João Marcos Bemfica Barbosa Ferreira
We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years.
August 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27596329/evaluation-of-acute-toxicity-genotoxicity-and-inhibitory-effect-on-acute-inflammation-of-an-ethanol-extract-of-morus-alba-l-moraceae-in-mice
#5
Alisson Macário de Oliveira, Matheus Ferreira do Nascimento, Magda Rhayanny Assunção Ferreira, Danielle Feijó de Moura, Talita Giselly Dos Santos Souza, Gabriela Cavalcante da Silva, Eduardo Henrique da Silva Ramos, Patrícia Maria Guedes Paiva, Paloma Lys de Medeiros, Teresinha Gonçalves da Silva, Luiz Alberto Lira Soares, Cristiano Aparecido Chagas, Ivone Antônia de Souza, Thiago Henrique Napoleão
ETHNOPHARMACOLOGICAL RELEVANCE: Morus alba L. (white mulberry) is used in traditional medicine worldwide, including Brazil. The leaves of this plant are used to treat inflammatory disorders. Universal interest in this plant necessitates studies on the toxicological safety and scientific substantiation of the medicinal properties of M. alba. In previous work, we investigated the acute toxicity of orally administered M. alba ethanol extract in mice. AIM OF THE STUDY: This work was designed to investigate the ethanol extract obtained from M...
September 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27580853/ecological-scenario-and-trypanosoma%C3%A2-cruzi-dtu-characterization-of-a-fatal-acute-chagas-disease-case-transmitted-orally-esp%C3%A3-rito-santo-state-brazil
#6
Maria Augusta Dario, Marina Silva Rodrigues, Juliana Helena da Silva Barros, Samanta Cristina das Chagas Xavier, Paulo Sérgio D'Andrea, André Luiz Rodrigues Roque, Ana Maria Jansen
BACKGROUND: Trypanosoma cruzi infection via oral route results in outbreaks or cases of acute Chagas disease (ACD) in different Brazilian regions and poses a novel epidemiological scenario. In the Espírito Santo state (southeastern Brazil), a fatal case of a patient with ACD led us to investigate the enzootic scenario to avoid the development of new cases. At the studied locality, Triatoma vitticeps exhibited high T. cruzi infection rates and frequently invaded residences. METHODS: Sylvatic and domestic mammals in the Rio da Prata locality, where the ACD case occurred, and in four surrounding areas (Baia Nova, Buenos Aires, Santa Rita and Todos os Santos) were examined and underwent parasitological and serological tests...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27550362/systematic-review-and-meta-analysis-of-the-pharmacokinetics-of-benznidazole-in-the-treatment-of-chagas-disease
#7
Matthew O Wiens, Steve Kanters, Edward Mills, Alejandro A Peregrina Lucano, Silvia Gold, Dieter Ayers, Luis Ferrero, Alejandro Krolewiecki
Chagas disease is a neglected parasitic illness affecting approximately 8 million people, predominantly in Latin America. Benznidazole is the drug of choice for treatment, although its availability has been limited. A paucity of knowledge of the pharmacokinetic properties of this drug has contributed to its limited availability in several jurisdictions. The objective of this study was to conduct a systematic literature review and a Bayesian meta-analysis of pharmacokinetic studies to improve estimates of the basic pharmacokinetic properties of benznidazole...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27533369/anatomopathological-aspects-of-acute-chagas-myocarditis-by-oral-transmission
#8
Dilma do Socorro Moraes de Souza, Marialva Tf Araujo, Paulo da Silva Garcez, Julio Cesar Branco Furtado, Maria Tereza Sanches Figueiredo, Rui M S Povoa
No abstract text is available yet for this article.
July 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27511897/high-resolution-molecular-typing-of-trypanosoma-cruzi-in-2-large-outbreaks-of-acute-chagas-disease-in-colombia
#9
Carolina Hernández, Mauricio Javier Vera, Zulma Cucunubá, Carolina Flórez, Omar Cantillo, Luz Stella Buitrago, Marina Stella González, Susanne Ardila, Liliana Zuleta Dueñas, Rubén Tovar, Luis Fernando Forero, Juan David Ramírez
Oral transmission of Trypanosoma cruzi has gained relevance because of its association with high morbidity and lethality rates. This transmission route is responsible for maintaining the infection of the parasite in sylvatic cycles, and human cases have been associated mainly with the consumption of food contaminated with triatomine feces or didelphid secretions. Several ecological changes allow the intrusion of sylvatic reservoirs and triatomines to the domestic environments with subsequent food contamination...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27476595/tyrosine-detoxification-is-an-essential-trait-in-the-life-history-of-blood-feeding-arthropods
#10
Marcos Sterkel, Hugo D Perdomo, Melina G Guizzo, Ana Beatriz F Barletta, Rodrigo D Nunes, Felipe A Dias, Marcos H F Sorgine, Pedro L Oliveira
Blood-feeding arthropods are vectors of infectious diseases such as dengue, Zika, Chagas disease, and malaria [1], and vector control is essential to limiting disease spread. Because these arthropods ingest very large amounts of blood, a protein-rich meal, huge amounts of amino acids are produced during digestion. Previous work on Rhodnius prolixus, a vector of Chagas disease, showed that, among all amino acids, only tyrosine degradation enzymes were overexpressed in the midgut compared to other tissues [2]...
August 22, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27376278/phase-transitions-of-isotropic-to-anisotropic-biocompatible-lipid-based-drug-delivery-systems-overcoming-insoluble-benznidazole-loading
#11
Letícia Streck, Víctor H V Sarmento, Paula R L Machado, Kleber J S Farias, Matheus F Fernandes-Pedrosa, Arnóbio Antônio da Silva-Júnior
Previous studies reported low benznidazole (BNZ) loading in conventional emulsions due to the weak interaction of the drug with the most common oils used to produce foods or pharmaceuticals. In this study, we focused on how the type of surfactant, surfactant-to-oil ratio w/w (SOR) and oil-to-water ratio w/w (OWR) change the phase behavior of different lipid-based drug delivery systems (LBDDS) produced by emulsion phase inversion. The surfactant mixture composed of soy phosphatidylcholine and sodium oleate (1:7, w/w, hydrophilic lipophilic balance = 16) stabilized medium chain triglyceride in water...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27324760/efficacy-of-lychnopholide-polymeric-nanocapsules-after-oral-and-intravenous-administration-in-murine-experimental-chagas-disease
#12
Carlos Geraldo Campos de Mello, Renata Tupinambá Branquinho, Maykon Tavares Oliveira, Matheus Marques Milagre, Dênia Antunes Saúde-Guimarães, Vanessa Carla Furtado Mosqueira, Marta de Lana
The etiological treatment of Chagas disease remains neglected. The compounds available show several limitations, mainly during the chronic phase. Lychnopholide encapsulated in polymeric nanocapsules (LYC-NC) was efficacious in mice infected with Trypanosoma cruzi and treated by intravenous administration during the acute phase (AP). As the oral route is preferred for treatment of chronic infections, such as Chagas disease, this study evaluated the use of oral LYC-NC in the AP and also compared it with LYC-NC administered to mice by the oral and intravenous routes during the chronic phase (CP)...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27192588/extraction-of-trypanosoma-cruzi-dna-from-food-a-contribution-to-the-elucidation-of-acute-chagas-disease-outbreaks
#13
Renata Trotta Barroso Ferreira, Aline Martins Melandre, Maria Luiza Cabral, Maria Regina Branquinho, Paola Cardarelli-Leite
INTRODUCTION: Before 2004, the occurrence of acute Chagas disease (ACD) by oral transmission associated with food was scarcely known or investigated. Originally sporadic and circumstantial, ACD occurrences have now become frequent in the Amazon region, with recently related outbreaks spreading to several Brazilian states. These cases are associated with the consumption of açai juice by waste reservoir animals or insect vectors infected with Trypanosoma cruzi in endemic areas. Although guidelines for processing the fruit to minimize contamination through microorganisms and parasites exist, açai-based products must be assessed for quality, for which the demand for appropriate methodologies must be met...
April 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27110022/post-transplantation-infections-in-bolivia
#14
S Arze, L Arze, C Abecia
Over 26 years, we found 46 infectious episodes in 350 kidney transplant recipients. Fifteen were urinary tract infections, recurrent in 4 patients. There were 8 cytomegalovirus infections, three of them fatal when intravenous (IV) ganciclovir was not available. Seven patients had a reactivation of tuberculosis (TB) in the pleura, cervical spine, lumbar spine, knee, ankle, skin and peritoneum, respectively, and were all resolved satisfactorily with conventional anti-TB therapy. Three patients transplanted before routine prophylaxis with the use of acyclovir developed an extensive herpes zoster infection in the 1st 6 months after transplantation, which was resolved with the use of oral acyclovir, and 1 had a disseminated herpes simplex infection resolved with the use of IV acyclovir...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27076330/attenuated-salmonella-sp-as-a-dna-delivery-system-for-trypanosoma-cruzi-antigens
#15
Augusto E Bivona, Natacha Cerny, Andrés Sánchez Alberti, Silvia I Cazorla, Emilio L Malchiodi
Chagas disease is an important neglected disease affecting thousands of people in the Americas. Novel strategies for prophylactic and therapeutic vaccines against the etiological agent, the intracellular protozoan Trypanosoma cruzi, are urgently needed. Vaccines based on attenuated virus and bacteria as a foreign DNA delivery system represent a strong advantage over naked DNA-based vaccines. Here we describe the use of attenuated Salmonella carrying a eukaryotic expression plasmid encoding a T. cruzi antigen...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27038796/host-cell-invasion-and-oral-infection-by-trypanosoma-cruzi-strains-of-genetic-groups-tci-and-tciv-from-chagasic-patients
#16
Fernando Yukio Maeda, Tatiana Mordente Clemente, Silene Macedo, Cristian Cortez, Nobuko Yoshida
BACKGROUND: Outbreaks of acute Chagas disease by oral infection have been reported frequently over the last ten years, with higher incidence in northern South America, where Trypanosoma cruzi lineage TcI predominates, being responsible for the major cause of resurgent human disease, and a small percentage is identified as TcIV. Mechanisms of oral infection and host-cell invasion by these parasites are poorly understood. To address that question, we analyzed T. cruzi strains isolated from chagasic patients in Venezuela, Guatemala and Brazil...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/26868066/vitamin-a-status-and-its-relationship-with-serum-zinc-concentrations-among-pregnant-women-who-have-previously-undergone-roux-en-y-gastric-bypass
#17
Cristiane Chagas, Cláudia Saunders, Silvia Pereira, Jacqueline Silva, Carlos Saboya, Andréa Ramalho
OBJECTIVE: To evaluate vitamin A status and its relationship with serum zinc concentrations among pregnant women who had previously undergone Roux-en-Y gastric bypass (RYGB), correlating these measures with anthropometric maternal characteristics and perinatal outcomes. METHODS: An analytical prospective longitudinal study was conducted at a clinic in Rio de Janeiro, Brazil, between March 3, 2008, and March 30, 2012, among women with singleton pregnancies who had previously undergone RYGB...
April 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26762336/neutrophils-influx-and-proinflammatory-cytokines-inhibition-by-sodium-salicylate-unlike-aspirin-in-candida-albicans-induced-peritonitis-model
#18
Priscilla Aparecida Tártari Pereira, Daniel Bini, Fernanda Bovo, Lucia Helena Faccioli, Marta Chagas Monteiro
Sodium salicylate (NaS) and aspirin (ASA) are known to have a variety of effects on microorganisms, such as fungus (C. albicans and C. neoformans), moreover, it have effects in leukocyte adhesion and migration in vitro. In this report, we investigated the effect of ASA and NaS in neutrophil migration and cytokine production in C. albicans-induced peritonitis murine model. For this, mice were treated intraperitoneally (i.p) or orally (po) with NaS or ASA; after they were stimulated i.p. with C. albicans, the cellular migration was evaluated 24 h after stimulation...
July 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/26747009/current-drug-therapy-and-pharmaceutical-challenges-for-chagas-disease
#19
REVIEW
José Bermudez, Carolina Davies, Analía Simonazzi, Juan Pablo Real, Santiago Palma
One of the most significant health problems in the American continent in terms of human health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite Trypanosoma cruzi. Infection was originally transmitted by reduviid insects, congenitally from mother to fetus, and by oral ingestion in sylvatic/rural environments, but blood transfusions, organ transplants, laboratory accidents, and sharing of contaminated syringes also contribute to modern day transmission. Likewise, Chagas disease used to be endemic from Northern Mexico to Argentina, but migrations have earned it global...
April 2016: Acta Tropica
https://www.readbyqxmd.com/read/26680095/cryptococcosis-presenting-as-a-colonic-ulcer-in-a-kidney-transplant-recipient-a-case-report
#20
F Cicora, J Petroni, J Roberti
We present a case of a 59-year-old woman with Chagas disease who received a kidney transplant. At month 44 post-transplantation, the patient presented with diarrhea that had persisted for 2 months. Colonoscopy showed a colon ulcer and differential diagnoses included cytomegalovirus, bacteria, or parasite infection; drug-related diarrhea; Crohn's disease; celiac disease; and malignancy. The ulcer tissue was positive for Cryptococcus neoformans. Successful treatment consisted of amphotericin B for 8 days and oral fluconazole (800 mg daily) for 3 months...
November 2015: Transplantation Proceedings
keyword
keyword
13011
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"