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Oral chagas

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https://www.readbyqxmd.com/read/28198632/engineering-oral-and-parenteral-amorphous-amphotericin-b-formulations-against-experimental-trypanosoma-cruzi-infections
#1
Miriam Rolón, Dolores R Serrano, Aikaterini Lalatsa, Esther de Pablo, Juan Jose Torrado, Maria Paloma Ballesteros, Anne Marie Healy, Celeste Vega, Cathia Coronel, Francisco Bolas-Fernández, Maria Auxiliadora Dea-Ayuela
Chagas disease (CD) is a parasitic zoonosis endemic in most mainland countries of Central and South America affecting nearly 10 million people, with 100 million people at high risk of contracting the disease. Treatment is only effective if received at the early stages of the disease. Only two drugs (benznidazole and nifurtimox) have so far been marketed and both share various limitations such as variable efficacy, many side effects and long duration of treatment, thus reducing compliance. The in vitro and in vivo efficacy of poly-aggregated amphotericin B (AmB), encapsulated poly-aggregated AmB in albumin microspheres (AmB-AME) and dimeric AmB - sodium deoxycholate micelles (AmB-NaDC) was evaluated...
February 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28167558/pharmacokinetic-and-tissue-distribution-of-benznidazole-after-oral-administration-in-mice
#2
Luísa Perin, Rodrigo Moreira da Silva, Kátia da Silva Fonseca, Jamille Mirelle de Oliveira Cardoso, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Israel Molina, Rodrigo Correa-Oliveira, Paula Melo de Abreu Vieira, Cláudia Martins Carneiro
Specific chemotherapy using Benznidazole (BNZ) for Chagas disease during the chronic stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been used to treat Chagas disease since the 1970s, few studies about the biodistribution of this drug exist. In this study, BNZ tissue biodistribution in a murine model and its pharmacokinetic profile in plasma were monitored. A bioanalytical high-performance liquid chromatography with an ultraviolet detector (HPLC-UV) method was developed and validated according to the European Medicines Agency for quantification of BNZ in organs and plasma samples prepared by liquid-liquid extraction using ethyl acetate...
February 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28146169/chagas-disease-transmission-by-consumption-of-game-meat-systematic-review
#3
Luiz Henrique Conde Sangenis, Marco Antonio Prates Nielebock, Ceumara da Silva Santos, Mateus Curty Carriello da Silva, Glauber Motta Ribeiro Bento
Objective: To evaluate the influence of game meat consumption in Chagas disease (CD) transmission, the conditions under which it occurs and the frequency of reports in the literature. Methods: Through systematic review, databases PubMed, LILACS, MEDLINE, and SciELO were consulted, and articles written in Portuguese, English, and Spanish were included, with no limitation over publication date. We used the following descriptors: oral, transmission, meat, wild animals, hunt, carnivory, and Chagas disease...
October 2016: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28132566/long-term-comparative-pharmacovigilance-of-orally-transmitted-chagas-disease-first-report
#4
Belkisyolé Alarcón de Noya, Raiza Ruiz-Guevara, Oscar Noya, Julio Castro, John Ossenkopp, Zoraida Díaz-Bello, Cecilia Colmenares, José Antonio Suárez, Oscar Noya-Alarcón, Laura Naranjo, Humberto Gutiérrez, Giuseppa Quinci, Jaime Torres
BACKGROUND: Two old drugs are the only choice against Trypanosoma cruzi and little is known about their secondary effects in the acute stage of oral-transmitted Chagas disease (ChD). METHODS: A cross-sectional analytical surveillance study was conducted in a sizable cohort of patients seen during the largest acute foodborne ChD microepidemic registered so far. Individuals were treated with benznidazole (BNZ) or nifurtimox (NFX). "Common Terminology Criteria for Adverse Events" was assessed to categorize side effects according to severity...
January 30, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28108369/jaburetox-affects-gene-expression-and-enzyme-activities-in-rhodnius-prolixus-a-chagas-disease-vector
#5
Leonardo L Fruttero, Natalia R Moyetta, Monique Siebra Krug, Valquiria Broll, Matheus V Coste Grahl, Rafael Real-Guerra, Fernanda Stanisçuaski, Celia R Carlini
Jaburetox, a recombinant peptide of ∼11kDa derived from one of the Canavalia ensiformis (Jack Bean) urease isoforms, is toxic and lethal to insects belonging to different orders when administered orally or via injection. Previous findings indicated that Jaburetox acts on insects in a complex fashion, inhibiting diuresis and the transmembrane potential of Malpighian tubules, interfering with muscle contractility and affecting the immune system. In vitro, Jaburetox forms ionic channels and alters permeability of artificial lipid membranes...
January 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28025938/trypanothione-reductase-and-superoxide-dismutase-as-current-drug-targets-for-trypanosoma-cruzi-an-overview-of-compounds-with-activity-against-chagas-disease
#6
Iván Beltrán-Hortelano, Silvia Pérez-Silanes, Silvia Galiano
It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi) as the causative agent of Chagas disease (CD), a neglected tropical disease with several socioeconomic, epidemiological and human health repercussions. Currently, there are only two commercialized drugs to treat CD in acute phase, nifurtimox and benznidazol, with several adverse side effects. Thus, new orally available and safe drugs for this parasitic infection are urgently required. One strategy of great importance in new drug discovery programmes is based on the search of molecules enabling to interfere with enzymes involved in T...
December 26, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27993415/orally-transmitted-chagas-disease
#7
REVIEW
Maria Teresa Filigheddu, Miguel Górgolas, José Manuel Ramos
Chagas disease is a zoonosis caused by protozoan parasite Trypanosoma cruzi, which is most frequently associated with a vectorial transmission. However, in recent years we have observed a significant increase in the oral transmission of the disease, associated mainly with the consumption of drinks made from fruit or other vegetables contaminated with triatomine faeces or secretions from infected mammals. After a latency period of 3 to 22 days after ingestion, the oral infection is characterized by more severe manifestations than those associated with vectorial transmission: prolonged fever, acute myocarditis with heart failure and, in some cases, meningoencephalitis...
February 9, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27876646/outcome-of-oral-infection-in-mice-inoculated-with-trypanosoma-cruzi-iv-of-the-western-brazilian-amazon
#8
Ana Paula Margioto Teston, Ana Paula de Abreu, Camila Piva Abegg, Mônica Lúcia Gomes, Max Jean de Ornelas Toledo
A new epidemiological view of American trypanosomiasis or Chagas disease has been formulated in recent decades. Oral transmission of the etiological agent of Chagas disease, Trypanosoma cruzi, has been the most common form of transmission. The T. cruzi discrete typing units TcI and TcIV have been involved in tens outbreaks of acute cases of Chagas disease in the Brazilian Amazon region. We investigated the intensity of infection in mice that were orally inoculated (OR group) with four strains of TcIV that were isolated from two outbreaks of acute Chagas disease that was orally acquired in the state of Amazonas, Brazil...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27758973/evolution-of-chagas-disease-in-brazil-epidemiological-perspective-and-challenges-for-the-future-a-critical-review
#9
Rafael Bello Corassa, Carmen Aceijas, Paula Aryane Brito Alves, Hemda Garelick
AIMS: This article aimed to provide a critical review of the evolution of Chagas' disease (ChD) in Brazil, its magnitude, historical development and management, and challenges for the future. METHODS: A literature search was performed using PubMed, SciELO and Google Scholar and throughout collected articles' references. Narrative analysis was structured around five main themes identified: vector transmission, control programme, transfusion, oral and congenital transmission...
October 10, 2016: Perspectives in Public Health
https://www.readbyqxmd.com/read/27679947/single-transverse-extended-incision-for-radical-neck-dissection
#10
José Francisco Sales Chagas, Maria Beatriz Nogueira Pascoal, José Luís Braga Aquino, Luís Antônio Brandi, Evandro Von Zuben Previtale, Ana Sofia Pontes Trillo, Otávio Alberto Curioni, Abrão Rapoport, Rogério Aparecido Dedivitis
OBJECTIVE: to assess the efficacy of the single transverse extended cervical incision in radical neck dissection. METHOD: we conducted a prospective study, from January 2008 to January 2009, with 18 patients undergoing surgical treatment of malignant tumors of the upper aero-digestive tract. The primary lesion was located in the oral cavity in eight cases, in the oropharynx in three, in the hypopharynx in three, in the larynx in two, in the maxillary sinus, and in one case, the primary injury was hidden...
July 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27627643/chronic-heart-disease-after-treatment-of-oral-acute-chagas-disease
#11
Andrei Fornanciari Antunes, Simão Gonçalves Maduro, Bruna Valessa Moutinho Pereira, Maria das Graças Vale Barbosa, Jorge Augusto de Oliveira Guerra, João Marcos Bemfica Barbosa Ferreira
We describe the recurrence of cardiac abnormalities in a patient treated during the acute phase of Chagas disease after outpatient follow-up of 5 years.
August 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27596329/evaluation-of-acute-toxicity-genotoxicity-and-inhibitory-effect-on-acute-inflammation-of-an-ethanol-extract-of-morus-alba-l-moraceae-in-mice
#12
Alisson Macário de Oliveira, Matheus Ferreira do Nascimento, Magda Rhayanny Assunção Ferreira, Danielle Feijó de Moura, Talita Giselly Dos Santos Souza, Gabriela Cavalcante da Silva, Eduardo Henrique da Silva Ramos, Patrícia Maria Guedes Paiva, Paloma Lys de Medeiros, Teresinha Gonçalves da Silva, Luiz Alberto Lira Soares, Cristiano Aparecido Chagas, Ivone Antônia de Souza, Thiago Henrique Napoleão
ETHNOPHARMACOLOGICAL RELEVANCE: Morus alba L. (white mulberry) is used in traditional medicine worldwide, including Brazil. The leaves of this plant are used to treat inflammatory disorders. Universal interest in this plant necessitates studies on the toxicological safety and scientific substantiation of the medicinal properties of M. alba. In previous work, we investigated the acute toxicity of orally administered M. alba ethanol extract in mice. AIM OF THE STUDY: This work was designed to investigate the ethanol extract obtained from M...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27580853/ecological-scenario-and-trypanosoma%C3%A2-cruzi-dtu-characterization-of-a-fatal-acute-chagas-disease-case-transmitted-orally-esp%C3%A3-rito-santo-state-brazil
#13
Maria Augusta Dario, Marina Silva Rodrigues, Juliana Helena da Silva Barros, Samanta Cristina das Chagas Xavier, Paulo Sérgio D'Andrea, André Luiz Rodrigues Roque, Ana Maria Jansen
BACKGROUND: Trypanosoma cruzi infection via oral route results in outbreaks or cases of acute Chagas disease (ACD) in different Brazilian regions and poses a novel epidemiological scenario. In the Espírito Santo state (southeastern Brazil), a fatal case of a patient with ACD led us to investigate the enzootic scenario to avoid the development of new cases. At the studied locality, Triatoma vitticeps exhibited high T. cruzi infection rates and frequently invaded residences. METHODS: Sylvatic and domestic mammals in the Rio da Prata locality, where the ACD case occurred, and in four surrounding areas (Baia Nova, Buenos Aires, Santa Rita and Todos os Santos) were examined and underwent parasitological and serological tests...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27550362/systematic-review-and-meta-analysis-of-the-pharmacokinetics-of-benznidazole-in-the-treatment-of-chagas-disease
#14
Matthew O Wiens, Steve Kanters, Edward Mills, Alejandro A Peregrina Lucano, Silvia Gold, Dieter Ayers, Luis Ferrero, Alejandro Krolewiecki
Chagas disease is a neglected parasitic illness affecting approximately 8 million people, predominantly in Latin America. Benznidazole is the drug of choice for treatment, although its availability has been limited. A paucity of knowledge of the pharmacokinetic properties of this drug has contributed to its limited availability in several jurisdictions. The objective of this study was to conduct a systematic literature review and a Bayesian meta-analysis of pharmacokinetic studies to improve estimates of the basic pharmacokinetic properties of benznidazole...
December 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27533369/anatomopathological-aspects-of-acute-chagas-myocarditis-by-oral-transmission
#15
Dilma do Socorro Moraes de Souza, Marialva Tf Araujo, Paulo da Silva Garcez, Julio Cesar Branco Furtado, Maria Tereza Sanches Figueiredo, Rui M S Povoa
No abstract text is available yet for this article.
July 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27511897/high-resolution-molecular-typing-of-trypanosoma-cruzi-in-2-large-outbreaks-of-acute-chagas-disease-in-colombia
#16
Carolina Hernández, Mauricio Javier Vera, Zulma Cucunubá, Carolina Flórez, Omar Cantillo, Luz Stella Buitrago, Marina Stella González, Susanne Ardila, Liliana Zuleta Dueñas, Rubén Tovar, Luis Fernando Forero, Juan David Ramírez
Oral transmission of Trypanosoma cruzi has gained relevance because of its association with high morbidity and lethality rates. This transmission route is responsible for maintaining the infection of the parasite in sylvatic cycles, and human cases have been associated mainly with the consumption of food contaminated with triatomine feces or didelphid secretions. Several ecological changes allow the intrusion of sylvatic reservoirs and triatomines to the domestic environments with subsequent food contamination...
October 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27476595/tyrosine-detoxification-is-an-essential-trait-in-the-life-history-of-blood-feeding-arthropods
#17
Marcos Sterkel, Hugo D Perdomo, Melina G Guizzo, Ana Beatriz F Barletta, Rodrigo D Nunes, Felipe A Dias, Marcos H F Sorgine, Pedro L Oliveira
Blood-feeding arthropods are vectors of infectious diseases such as dengue, Zika, Chagas disease, and malaria [1], and vector control is essential to limiting disease spread. Because these arthropods ingest very large amounts of blood, a protein-rich meal, huge amounts of amino acids are produced during digestion. Previous work on Rhodnius prolixus, a vector of Chagas disease, showed that, among all amino acids, only tyrosine degradation enzymes were overexpressed in the midgut compared to other tissues [2]...
August 22, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27376278/phase-transitions-of-isotropic-to-anisotropic-biocompatible-lipid-based-drug-delivery-systems-overcoming-insoluble-benznidazole-loading
#18
Letícia Streck, Víctor H V Sarmento, Paula R L Machado, Kleber J S Farias, Matheus F Fernandes-Pedrosa, Arnóbio Antônio da Silva-Júnior
Previous studies reported low benznidazole (BNZ) loading in conventional emulsions due to the weak interaction of the drug with the most common oils used to produce foods or pharmaceuticals. In this study, we focused on how the type of surfactant, surfactant-to-oil ratio w/w (SOR) and oil-to-water ratio w/w (OWR) change the phase behavior of different lipid-based drug delivery systems (LBDDS) produced by emulsion phase inversion. The surfactant mixture composed of soy phosphatidylcholine and sodium oleate (1:7, w/w, hydrophilic lipophilic balance = 16) stabilized medium chain triglyceride in water...
June 30, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27324760/efficacy-of-lychnopholide-polymeric-nanocapsules-after-oral-and-intravenous-administration-in-murine-experimental-chagas-disease
#19
Carlos Geraldo Campos de Mello, Renata Tupinambá Branquinho, Maykon Tavares Oliveira, Matheus Marques Milagre, Dênia Antunes Saúde-Guimarães, Vanessa Carla Furtado Mosqueira, Marta de Lana
The etiological treatment of Chagas disease remains neglected. The compounds available show several limitations, mainly during the chronic phase. Lychnopholide encapsulated in polymeric nanocapsules (LYC-NC) was efficacious in mice infected with Trypanosoma cruzi and treated by intravenous administration during the acute phase (AP). As the oral route is preferred for treatment of chronic infections, such as Chagas disease, this study evaluated the use of oral LYC-NC in the AP and also compared it with LYC-NC administered to mice by the oral and intravenous routes during the chronic phase (CP)...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27192588/extraction-of-trypanosoma-cruzi-dna-from-food-a-contribution-to-the-elucidation-of-acute-chagas-disease-outbreaks
#20
Renata Trotta Barroso Ferreira, Aline Martins Melandre, Maria Luiza Cabral, Maria Regina Branquinho, Paola Cardarelli-Leite
INTRODUCTION: Before 2004, the occurrence of acute Chagas disease (ACD) by oral transmission associated with food was scarcely known or investigated. Originally sporadic and circumstantial, ACD occurrences have now become frequent in the Amazon region, with recently related outbreaks spreading to several Brazilian states. These cases are associated with the consumption of açai juice by waste reservoir animals or insect vectors infected with Trypanosoma cruzi in endemic areas. Although guidelines for processing the fruit to minimize contamination through microorganisms and parasites exist, açai-based products must be assessed for quality, for which the demand for appropriate methodologies must be met...
April 2016: Revista da Sociedade Brasileira de Medicina Tropical
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