Patricia Khashayar, Paula Lopes, Peter Ragaert, Richard Hoogenboom, Daniel Latta, Rainer Gransee, Daniel Lenartowicz, Phil Biggs, Ikerne Etxebarria, Barbara Luegger, Barbara Obermayer-Pietsch, Hans Peter Dimai, Jan Vanfleteren
Despite the increasing efforts in improving bone health assessments, current diagnostics suffer from critical shortcomings. The present article therefore describes a multiplex label-free immunosensor designed and validated for the assessment of two bone turnover markers (BTMs), namely beta isomerized C-terminal telopeptide of type I collagen (CTx) and Procollagen I Intact N-Terminal (PINP), the combination of which is needed to illustrate an accurate overview of bone health. The immunosensor was then tested outside and inside of a microsystem, with the aim of becoming compatible with a point of care system fabricated for automated assessment of these biomarkers later-on at patient side...
May 13, 2024: Analytical Methods: Advancing Methods and Applications