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https://www.readbyqxmd.com/read/29232706/biventricular-differences-in-%C3%AE-adrenergic-receptor-signaling-following-burn-injury
#1
Ashley N Guillory, Robert P Clayton, Anesh Prasai, Amina El Ayadi, David N Herndon, Celeste C Finnerty
Burn injury detrimentally affects the myocardium, primarily due to over-activation of β-adrenergic receptors (β-AR). Autopsy reports from our institution reveal that patients often suffer from right ventricle (RV) failure. Since burn injury affects β-AR signaling in the left ventricle (LV), we proposed that β-AR signaling may also be altered in the RV. A rodent model with a scald burn of 60% of the total body surface area was used to test this hypothesis. Ventricles were isolated 7 days post-burn. We examined the expression of β-ARs via Western blotting and the mRNA expression of downstream signaling proteins via qRT-PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29232489/achieving-biocompatible-sabre-an-in-vitro-cytotoxicity-study
#2
Simon Duckett, Anand Manoharan, Peter J Rayner, Michael J Burns, Wissam Iali, V Hugh Perry
Production of a biocompatible hyperpolarized bolus by Signal Amplification By Reversible Exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to pre-clinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Here we exemplify the cytotoxicity of the SABRE approach using in vitro cell assay. We conclude that the main cause of observed toxicity is due to the SABRE catalyst. Thus we develop two catalyst removal methods, one involving deactivation and ion-exchange chromatography and the second biphasic catalysis...
December 12, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29231870/improving-the-care-and-treatment-of-monkeypox-patients-in-low-resource-settings-applying-evidence-from-contemporary-biomedical-and-smallpox-biodefense-research
#3
REVIEW
Mary G Reynolds, Andrea M McCollum, Beatrice Nguete, Robert Shongo Lushima, Brett W Petersen
Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness and poor outcomes. Improving care necessitates developing a better understanding of the range of clinical manifestations-including complications and sequelae-as well as of features of illness that may be predictive of illness severity and poor outcomes...
December 12, 2017: Viruses
https://www.readbyqxmd.com/read/29231755/pharmaceutical-aspects-of-silver-nanoparticles
#4
Prateek Mathur, Swati Jha, Suman Ramteke, N K Jain
Silver nanoparticles are particles in the size ranging between 1 and 100 nm. The two major methods used for synthesis of silver nanoparticle are the physical and chemical methods with the disadvantage that they are expensive and can also have toxicity. Biological method is being used as an expedient alternative, as this approach is environment-friendly and less toxic and it includes plant extracts, microorganism, fungi, etc. The major applications of silver nanoparticles in the medical field include diagnostic applications and therapeutic applications, apart from its antimicrobial activity...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29229857/effect-of-oil-palm-sustainability-certification-on-deforestation-and-fire-in-indonesia
#5
Kimberly M Carlson, Robert Heilmayr, Holly K Gibbs, Praveen Noojipady, David N Burns, Douglas C Morton, Nathalie F Walker, Gary D Paoli, Claire Kremen
Many major corporations and countries have made commitments to purchase or produce only "sustainable" palm oil, a commodity responsible for substantial tropical forest loss. Sustainability certification is the tool most used to fulfill these procurement policies, and around 20% of global palm oil production was certified by the Roundtable on Sustainable Palm Oil (RSPO) in 2017. However, the effect of certification on deforestation in oil palm plantations remains unclear. Here, we use a comprehensive dataset of RSPO-certified and noncertified oil palm plantations (∼188,000 km2) in Indonesia, the leading producer of palm oil, as well as annual remotely sensed metrics of tree cover loss and fire occurrence, to evaluate the impact of certification on deforestation and fire from 2001 to 2015...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29229195/a-comparison-of-two-different-fluid-resuscitation-management-protocols-for-pediatric-burn-patients-a-retrospective-study
#6
Miao Huang, Jun-Feng Chen, Li-Ying Chen, Li-Qin Pan, Xiao-Jian Li, Jie-Yu Ye, Hui-Yi Tan
OBJECTIVE: Pediatric burn patients are more susceptible to burn shock than adults, and an effective fluid management protocol is critical to successful resuscitation. Our research aim was to investigate the safety and efficacy of two protocols for pediatric burn patients for use within the first 24h. METHODS: A total of 113 pediatric burn patients were enrolled from January 2007 to October 2012. Of those patients, 57 received fluid titration regimens of alternating crystalloids and colloids once within 2h in the first 24h after burn (Group A), whereas the remaining patients received regimens of alternating crystalloids and colloids once within 1h in the first 24h after burn (Group B)...
December 8, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29229139/comparison-of-the-lund-and-browder-table-to-computed-tomography-scan-three-dimensional-surface-area-measurement-for-a-pediatric-cohort
#7
R Wolfgang Rumpf, William C L Stewart, Stephen K Martinez, Chandra Y Gerrard, Natalie L Adolphi, Rajan Thakkar, Alan Coleman, Adrian Rajab, William C Ray, Renata Fabia
BACKGROUND: Treating burns effectively requires accurately assessing the percentage of the total body surface area (%TBSA) affected by burns. Current methods for estimating %TBSA, such as Lund and Browder (L&B) tables, rely on historic body statistics. An increasingly obese population has been blamed for increasing errors in %TBSA estimates. However, this assumption has not been experimentally validated. We hypothesized that errors in %TBSA estimates using L&B were due to differences in the physical proportions of today's children compared with children in the early 1940s when the chart was developed and that these differences would appear as body mass index (BMI)-associated systematic errors in the L&B values versus actual body surface areas...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228019/loci-and-pathways-associated-with-uterine-capacity-for-pregnancy-and-fertility-in-beef-cattle
#8
Mahesh Neupane, Thomas W Geary, Jennifer N Kiser, Gregory W Burns, Peter J Hansen, Thomas E Spencer, Holly L Neibergs
Infertility and subfertility negatively impact the economics and reproductive performance of cattle. Of note, significant pregnancy loss occurs in cattle during the first month of pregnancy, yet little is known about the genetic loci influencing pregnancy success and loss in cattle. To identify quantitative trait loci (QTL) with large effects associated with early pregnancy loss, Angus crossbred heifers were classified based on day 28 pregnancy outcomes to serial embryo transfer. A genome wide association analysis (GWAA) was conducted comparing 30 high fertility heifers with 100% success in establishing pregnancy to 55 subfertile heifers with 25% or less success...
2017: PloS One
https://www.readbyqxmd.com/read/29227988/fire-frequency-drives-decadal-changes-in-soil-carbon-and-nitrogen-and-ecosystem-productivity
#9
Adam F A Pellegrini, Anders Ahlström, Sarah E Hobbie, Peter B Reich, Lars P Nieradzik, A Carla Staver, Bryant C Scharenbroch, Ari Jumpponen, William R L Anderegg, James T Randerson, Robert B Jackson
Fire frequency is changing globally and is projected to affect the global carbon cycle and climate. However, uncertainty about how ecosystems respond to decadal changes in fire frequency makes it difficult to predict the effects of altered fire regimes on the carbon cycle; for instance, we do not fully understand the long-term effects of fire on soil carbon and nutrient storage, or whether fire-driven nutrient losses limit plant productivity. Here we analyse data from 48 sites in savanna grasslands, broadleaf forests and needleleaf forests spanning up to 65 years, during which time the frequency of fires was altered at each site...
December 11, 2017: Nature
https://www.readbyqxmd.com/read/29227879/re-thinking-pre-drinking-implications-from-a-sample-of-teenagers-who-drink-in-private-settings
#10
James Wilson, Rowan P Ogeil, Tina Lam, Simon Lenton, Belinda Lloyd, Lucy Burns, Alexandra Aiken, William Gilmore, Tanya Chikritzhs, Richard Mattick, Dan I Lubman, Steve Allsop
BACKGROUND: Pre-drinking is often defined as an economically-minded set of drinking practices engaged in prior to attending public entertainment areas, such as licensed venues. This paper explores motivations and practical considerations that a sample of teenagers describes as significant to 'pre-drinking', despite not attending licensed premises during their most recent risky drinking session. METHODS: Data were derived from the mixed-methods Young Australians Alcohol Reporting System (YAARS) project...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29227637/urban-organic-aerosol-exposure-spatial-variations-in-composition-and-source-impacts
#11
Hugh Z Li, Timothy R Dallmann, Xiang Li, Peishi Gu, Albert A Presto
We conducted a mobile sampling campaign in a historically industrialized terrain (Pittsburgh, PA) targeting spatial heterogeneity of organic aerosol. Thirty-six sampling sites were chosen based on stratification of traffic, industrial source density, and elevation. We collected organic carbon (OC) on quartz filters, quantified different OC components with thermal-optical analysis, and grouped them based on volatility in decreasing order (OC1, OC2, OC3, OC4, and pyrolyzed carbon (PC)). We compared our ambient OC concentrations (both gas and particle phase) to similar measurements from vehicle dynamometer tests, cooking emissions, biomass burning emissions, and a highway traffic tunnel...
December 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29227522/pediatric-pharmaceutical-ingestions
#12
Jennifer A Lowry, Michele Burns, Diane P Calello
Pharmaceutical ingestions comprise an important part of pediatric toxicology. Based on the 2015 Annual Report of the American Association of Poison Control Centers' National Poison Data System, coupled with recent epidemiology articles on the topic of pediatric toxicology, it is apparent that poison prevention education has not been completely successful in decreasing exposures to toxic drugs. From the unintentional ingestion in a toddler due to unsafe storage to the intentional adolescent ingestion for misuse and abuse, pharmaceutical medications continue to cause harm...
December 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29227460/neuropathic-like-ocular-pain-and-nonocular-comorbidities-correlate-with-dry-eye-symptoms
#13
Victoria S Chang, Terri P Rose, Carol L Karp, Roy C Levitt, Constantine Sarantopoulos, Anat Galor
OBJECTIVE: To evaluate the association between dry eye (DE) symptoms and neuropathic-like ocular pain (NOP) features, chronic pain conditions, depression, and anxiety in patients presenting for routine ophthalmic examinations. METHODS: Two hundred thirty-three consecutive patients ≥18 years of age presenting to a comprehensive eye clinic between January and August 2016 were included in this study. Information on demographics, chronic pain conditions, medication use, DE symptoms (dry eye questionnaire, DEQ5), NOP complaints (burning; wind, light, and temperature sensitivity), depression, and anxiety indices (patient health questionnaire 9, PHQ-9 and symptom checklist 90-revised, SCL-90-R) were collected for each individual...
December 7, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29226791/counting-the-cost-of-afrophobia-post-migration-adaptation-and-mental-health-challenges-of-african-refugees-in-south-africa
#14
Lindokuhle Thela, Andrew Tomita, Varsha Maharaj, Mpho Mhlongo, Jonathan K Burns
There are few studies on the role of migration within sub-Saharan Africa and its relation to the development of mental illness. We investigated post-resettlement adaptation and mental health challenges of African refugees/migrants in Durban, South Africa. We interviewed 335 African help-seeking refugees/migrants for anxiety, depression (25-item Hopkins Symptom Checklist) and post-traumatic stress symptoms (30-item Harvard Trauma Questionnaire). Socio-demographic and migration history, focusing on post-migration circumstances and experiences of discrimination in the host country, were obtained...
October 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29226306/symbioses-with-nitrogen-fixing-bacteria-nodulation-and-phylogenetic-data-across-legume-genera
#15
Michelle E Afkhami, D Luke Mahler, Jean H Burns, Marjorie G Weber, Martin F Wojciechowski, Janet Sprent, Sharon Y Strauss
How species interactions shape global biodiversity and influence diversification is a central - but also data-hungry - question in evolutionary ecology. Microbially-based mutualisms are widespread and could cause diversification by ameliorating stress and thus allowing organisms to colonize and adapt to otherwise unsuitable habitats. Yet the role of these interactions in generating species diversity has received limited attention, especially across large taxonomic groups. In the massive angiosperm family Leguminosae, plants often associate with root-nodulating bacteria that ameliorate nutrient stress by fixing atmospheric nitrogen...
December 11, 2017: Ecology
https://www.readbyqxmd.com/read/29226160/the-significance-of-changes-in-platelet-concentration-during-the-early-phase-after-severe-burn-injury-in-a-chinese-mass-casualty
#16
Beiming Shou, Junqiang Li, Chenqi Tang, Qian Tan, Dongfeng Zheng, Binwei Sun, Lanjun Nie, Hongwei Zhang, Yanan Jiang, Chunming Wang, Yanwen Wu
Background: Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course of the disease in victims of a mass burn casualty. Methods: A total of 180 patients were involved in the "8.2" Kunshan explosion accident in China. The examined data included age, gender, total burn area (% TBSA), third-degree burn area (% TBSA), and platelet concentration within the first 5 days after the burn injury...
2017: Burns and Trauma
https://www.readbyqxmd.com/read/29225922/using-participatory-learning-action-pla-research-techniques-for-inter-stakeholder-dialogue-in-primary-healthcare-an-analysis-of-stakeholders-experiences
#17
T de Brún, M O'Reilly-de Brún, E Van Weel-Baumgarten, N Burns, C Dowrick, C Lionis, C O'Donnell, F S Mair, M Papadakaki, A Saridaki, W Spiegel, C Van Weel, M Van den Muijsenbergh, A MacFarlane
Plain English summary: It is important for health care workers to know the needs and expectations of their patients. Therefore, service users have to be involved in research. To achieve a meaningful dialogue between service users, healthcare workers and researchers, participatory methods are needed. This paper describes how the application of a specific participatory methodology, Participatory Learning and Action (PLA) can lead to such a meaningful dialogue. In PLA all stakeholders are regarded as equal partners and collaborators in research...
2017: Research Involvement and Engagement
https://www.readbyqxmd.com/read/29225494/rolling-resistance-of-shallow-granular-deformation
#18
Keaton J Burns, Neil J Balmforth, Ian J Hewitt
Experiments are conducted to measure the resistance experienced by light cylinders rolling over flat beds of granular media. Sand and glass spheres are used for the beds. The trajectories of the rolling cylinders are determined through optical tracking, and velocity and acceleration data are inferred through fits to these trajectories. The rolling resistance is dominated by a velocity-independent component, but a velocity-dependent drag exceeding the expected strength of air drag is also observed. The results are compared to a theoretical model based on a cohesionless Mohr-Coulomb rheology for a granular medium in the presence of gravity...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29225150/decellularised-conjunctiva-for-ocular-surface-reconstruction
#19
Joana Witt, Sonja Mertsch, Maria Borrelli, Jana Dietrich, Gerd Geerling, Stefan Schrader, Kristina Spaniol
Conjunctival reconstruction is an integral component of ocular surface restoration. Decellularised tissues are frequently used clinically for tissue engineering. This study identifies porcine decellularised conjunctiva (PDC) and human decellularised conjunctiva (HDC) as promising substitutes for conjunctival reconstruction. PDC and HDC were nearly DNA-free, structurally intact and showed no cytotoxic effects in vitro, which was confirmed by DNA quantification, histology, transmission electron microscopy, collagen quantification and cytotoxicity assay...
December 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29225114/fructose-induced-inflammation-and-increased-cortisol-a-new-mechanism-for-how-sugar-induces-visceral-adiposity
#20
REVIEW
James J DiNicolantonio, Varshil Mehta, Neema Onkaramurthy, James H O'Keefe
Traditionally, the leading hypothesis regarding the development of obesity involves caloric imbalance, whereby the amount of calories consumed exceeds the amount of calories burned which causes obesity. Another hypothesis for why we get fat has surfaced in the last decade which is the idea that the overconsumption of added sugars and refined carbohydrates induce insulin resistance and high insulin levels causing obesity. While insulin is a fat-storing hormone, this hypothesis does not explain visceral adiposity, or why certain people are found to have fat stored in and around their organs...
December 7, 2017: Progress in Cardiovascular Diseases
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