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https://www.readbyqxmd.com/read/29457730/cryo-spectroscopy-studies-of-intact-light-harvesting-antennas-reveal-empirical-electronic-energy-transitions-in-two-cyanobacteria-species
#1
Albert Collins Nganou Assonkeng, Noam Adir, Martin Mkandawire
Understanding of electronic energy transition (EET) mechanisms from the light-harvesting unit to the reaction centre in a natural system has been limited by; (a) the use of conventional transient time-resolved spectroscopy at room temperature, which result in high signal-to-noise ratio; and (b) examining extracts instead of intact light-harvesting units. Here, we report previously unknown differences and new insight in EET of two cyanobacteria species, Acaryochloris marina and Thermosynechoccocus vulvanus, which have been found only after using Uv-vis, hole-burning and fluorescence spectroscopy at ultra-low temperature and examining their intact light-harvesting unit, phycobilisomes (PBS)...
February 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29457376/delivery-of-allogeneic-adipose-stem-cells-in-polyethylene-glycol-fibrin-hydrogels-as-an-adjunct-to-meshed-autografts-after-sharp-debridement-of-deep-partial-thickness-burns
#2
David M Burmeister, Randolph Stone, Nicole Wrice, Alfred Laborde, Sandra C Becerra, Shanmugasundaram Natesan, Robert J Christy
Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose-derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model...
February 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29457215/the-effect-of-anaesthetic-technique-during-primary-breast-cancer-surgery-on-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-return-to-intended-oncological-therapy
#3
A Ní Eochagáin, D Burns, B Riedel, D I Sessler, D J Buggy
Inflammation and immunosuppression contribute to the pathogenesis of cancer. An increased neutrophil-lymphocyte ratio reflects these processes and is associated with adverse cancer outcomes. Whether anaesthetic technique for breast cancer surgery influences these factors, and potentially cancer recurrence, remains unknown. We conducted a secondary analysis in patients enrolled in an ongoing trial of anaesthetic technique on breast cancer recurrence. The primary hypothesis was that postoperative neutrophil-lymphocyte ratio is lower in patients allocated to receive propofol-paravertebral rather than inhalational agent-opioid anaesthesia for primary breast cancer surgery...
February 19, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29456916/spine-degenerative-conditions-and-their-treatments-national-trends-in-the-united-states-of-america
#4
Zorica Buser, Brandon Ortega, Anthony D'Oro, William Pannell, Jeremiah R Cohen, Justin Wang, Ray Golish, Michael Reed, Jeffrey C Wang
Study Design: Retrospective database study. Objective: Low back and neck pain are among the top leading causes of disability worldwide. The aim of our study was to report the current trends on spine degenerative disorders and their treatments. Methods: Patients diagnosed with lumbar or cervical spine conditions within the orthopedic subset of Medicare and Humana databases (PearlDiver). From the initial cohorts we identified subgroups based on the treatment: fusion or nonoperative within 1 year from diagnosis...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456380/moxibustion-artemisia-plant-at-acupuncture-point-as-alternative-therapy-in-hypertension-a-promising-approach
#5
Mohammad Jamshed Siddiqui, Mohamad Fadly Bin Kamarudin, Abdul Kareem Mohammed Al-Shami, Siti Zaiton Mat So'ad, Shazia Qasim Jamshed
Hypertension is a pathological condition in which the blood pressure is higher than under normal physiological conditions, i.e., 140/90 mmHg or higher. Blood pressure is measured as the force exerted by the blood pumped by the heart against the walls of arteries (aorta) and distributed throughout the body. Use of complementary and alternative medicine as a cure for hypertension is a common phenomenon because of the high risk of cardiovascular complications and kidney diseases caused by conventional Western medicine...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456099/time-to-start-putting-down-the-knife-a-systematic-review-of-burns-excision-tools-of-randomised-and-non-randomised-trials
#6
REVIEW
Sarah-Jayne Edmondson, Irfan Ali Jumabhoy, Alexandra Murray
AIMS: Dermal preservation during acute burn excision is key to obtaining superior healing/scar outcomes, however, determining the most appropriate excision tool is an ongoing challenge. Novel tool development means the knife is no longer our only option, yet for the majority it remains the gold standard. This systematic review aims to evaluate evidence for burns excision approaches (knife/hydrosurgery/enzymatic). METHODS: CENTRAL, EMBASE, MEDLINE (1946-2017) were searched with MeSH terms: 'debridement', 'burns', 'sharp', 'enzymatic', 'hydrosurgery'...
February 15, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29456098/arf-excimer-laser-debrides-burns-without-destruction-of-viable-tissue-a-pilot-study
#7
Atulya Prasad, Katarzyna M Sawicka, Kelly B Pablo, Lauren K Macri, Jerome Felsenstein, James J Wynne, Richard A F Clark
INTRODUCTION: Recent evidence indicates that early removal of eschar by tangential debridement can promote healing. Laser debridement can be used for debridement of areas that prove challenging for debridement using tangential excision. In particular, irradiation with an ArF excimer laser ablates desiccated eschar and is self-terminating, preserving hydrated or viable tissue. METHODS: Thermal burns were created on the flanks of two outbred, female Yorkshire pigs using aluminum bars heated to 70°C and applied for different lengths of time...
February 15, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29456021/brain-nat8l-knockdown-suppresses-spongiform-leukodystrophy-in-an-aspartoacylase-deficient-canavan-disease-mouse-model
#8
Peter Bannerman, Fuzheng Guo, Olga Chechneva, Travis Burns, Xiaoqing Zhu, Yan Wang, Bokyung Kim, Naveen K Singhal, Jennifer A McDonough, David Pleasure
Canavan disease, a leukodystrophy caused by loss-of-function ASPA mutations, is characterized by brain dysmyelination, vacuolation, and astrogliosis ("spongiform leukodystrophy"). ASPA encodes aspartoacylase, an oligodendroglial enzyme that cleaves the abundant brain amino acid N-acetyl-L-aspartate (NAA) to L-aspartate and acetate. Aspartoacylase deficiency results in a 50% or greater elevation in brain NAA concentration ([NAAB ]). Prior studies showed that homozygous constitutive knockout of Nat8l, the gene encoding the neuronal NAA synthesizing enzyme N-acetyltransferase 8-like, prevents aspartoacylase-deficient mice from developing spongiform leukodystrophy...
January 10, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29455343/the-first-isolation-of-westerdykella-dispersa-in-a-critically-burned-patient
#9
Bretislav Lipovy, Iva Kocmanova, Jakub Holoubek, Marketa Hanslianova, Matej Bezdicek, Hana Rihova, Ivan Suchanek, Pavel Brychta
Patients with critical thermal trauma belong to one of the most high-risk groups for development of infectious complications. Fungal infections are not among frequent complications during therapy of patients with thermal trauma, yet their incidence dramatically aggravates the prognosis for patients with this disorder. In the case report, we present the case of a young man with a critical burn, where Westerdykella dispersa was isolated. Identification of the pathogen was provided with a combination of cultivation and molecular biological confirmation...
February 17, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29455128/source-apportionment-of-ambient-pm-2-5-in-two-locations-in-central-tehran-using-the-positive-matrix-factorization-pmf-model
#10
Sina Taghvaee, Mohammad H Sowlat, Amirhosein Mousavi, Mohammad Sadegh Hassanvand, Masud Yunesian, Kazem Naddafi, Constantinos Sioutas
In this study, the positive matrix factorization (PMF) model was used for source apportionment of ambient PM2.5 in two locations in the central Tehran from May 2012 through June 2013. The average PM2.5 mass concentrations were 30.9 and 33.2μg/m3 in Tohid retirement home and the school dormitory, respectively. Metals and trace elements, water-soluble ions, and PM2.5 mass concentrations were used as inputs to the model. Concentrations of elemental and organic carbon (EC and OC), and meteorological data were also used as auxiliary variables to help with the factor identification and interpretation...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29455032/sevoflurane-for-procedural-sedation-in-critically-ill-patients-a-pharmacokinetic-comparative-study-between-burn-and-non-burn-patients
#11
Sebastien Perbet, Daniel Bourdeaux, Alexandre Lenoire, Claire Biboulet, Bruno Pereira, Malha Sadoune, Benoit Plaud, Jean-Marie Launay, Jean-Etienne Bazin, Valerie Sautou, Alexandre Mebazaa, Pascal Houze, Jean-Michel Constantin, Matthieu Legrand
BACKGROUND: Sevoflurane has anti-inflammatory proprieties and short lasting effects making it of interest for procedural sedation in critically ill patients. We evaluated the pharmacokinetics of sevoflurane and metabolites in severely ill burn patients and controls. The secondary objective was to assess potential kidney injury. METHODS: prospective interventional study in a burn and a surgical intensive care unit 24 mechanically ventilated critically ill patients (12 burns, 12 controls) were included,...
February 15, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29454711/outcomes-of-post-burn-flexion-contracture-release-under-tourniquet-versus-tumescent-technique-in-children
#12
Muhammad Mustehsan Bashir, Muhammad Sohail, Ahmad Wahab, Umar Iqbal, Rehan Qayyum, Saadia Nosheen Jan
OBJECTIVE: To compare the clinical outcomes of release of flexion contractures after burn of the hand in children using tourniquet or tumescent technique in terms of operative time, postoperative pain score, and percentage of graft take. METHODS: Patients aged 3 to 12 years who required release of post-burn flexion contractures involving volar aspect of palm and fingers were enrolled from outpatient clinic. Patients were randomized in 1:1 ratio to the use of either tumescent technique or tourniquet during contracture release...
February 14, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29454710/experiences-of-guilt-shame-and-blame-in-those-affected-by-burns-a-qualitative-systematic-review
#13
REVIEW
Rachel Kornhaber, Charmaine Childs, Michelle Cleary
BACKGROUND: A significant burn can severely impact the lives of survivors and their carers. This systematic review sought to incorporate the experiences of guilt, blame and shame across the lifespan for burn survivors, their families as well as the experiences of the parents of burned children. METHODS: A systematic review of qualitative studies on the experiences and perspectives of guilt, blame and shame by those affected by burn trauma across the lifespan. The databases, Pubmed, Scopus, EMBASE, CINAHL, PsychINFO were systematically searched...
February 14, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29454217/morphologies-and-elemental-compositions-of-local-biomass-burning-particles-at-urban-and-glacier-sites-in-southeastern-tibetan-plateau-results-from-an-expedition-in-2010
#14
Tafeng Hu, Junji Cao, Chongshu Zhu, Zhuzi Zhao, Suixin Liu, Daizhou Zhang
Many studies indicate that the atmospheric environment over the southern part of the Tibetan Plateau is influenced by aged biomass burning particles that are transported over long distances from South Asia. However, our knowledge of the particles emitted locally (within the plateau region) is poor. We collected aerosol particles at four urban sites and one remote glacier site during a scientific expedition to the southeastern Tibetan Plateau in spring 2010. Weather and backward trajectory analyses indicated that the particles we collected were more likely dominated by particles emitted within the plateau...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454204/scanning-vertical-distributions-of-typical-aerosols-along-the-yangtze-river-using-elastic-lidar
#15
Shidong Fan, Cheng Liu, Zhouqing Xie, Yunsheng Dong, Qihou Hu, Guangqiang Fan, Zhengyi Chen, Tianshu Zhang, Jingbo Duan, Pengfei Zhang, Jianguo Liu
In recent years, China has experienced heavy air pollution, especially haze caused by particulate matter (PM). The compositions, horizontal distributions, transport, and chemical formation mechanisms of PM and its precursors have been widely investigated in China based on near-ground measurements. However, the understanding of the distributions and physical and chemical processes of PM in the vertical direction remains limited. In this study, an elastic lidar was employed to investigate the vertical profiles of aerosols along the Yangtze River during the Yangtze River Campaign of winter 2015...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454155/immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-nsclc-approaches-on-special-subgroups-and-unresolved-burning-questions
#16
REVIEW
J Remon, N Vilariño, N Reguart
Immune checkpoint inhibitors (ICIs) have been incorporated in the treatment strategy of advanced non-small cell lung cancer (NSCLC). Beyond the already approved indications in first- and second-line setting of advanced NSCLC, new data has recently emerged demonstrating its efficacy in locally advanced disease as maintenance after chemo-radiotherapy and currently several trials are also exploring its efficacy in earlier stages of the disease to evaluate whether these results could be extrapolated to the adjuvant setting...
February 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29453974/genetically-modified-bone-mesenchymal-stem-cells-with-tgf-%C3%AE-3-improve-wound-healing-and-reduce-scar-tissue-formation-in-a-rabbit-model
#17
Mingyong Li, Lin Qiu, Wei Hu, Xiang Deng, Hanfeng Xu, Youhan Cao, Zijian Xiao, Liangyu Peng, Shawn Johnson, Lyundup Alexey, Paul A Kingston, Qing Li, Yuanyuan Zhang
Extensive scar tissue formation often occurs after severe burn injury, trauma, or as one of complications after surgical intervention. Despite significant therapeutic advances, it is still a significant challenge to manage massive scar tissue formation while also promoting normal wound healing. The goal of this study was to investigate the therapeutic effect of bone mesenchymal stem cells (BMSCs) that were genetically modified to overexpress transforming growth factor-beta 3 (TGF-β 3 ), an inhibitor of myofibroblast proliferation and collagen type I deposition, on full-thickness cutaneous wound healing in a rabbit model...
February 14, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29453855/nerve-reinnervation-and-itch-behaviour-in-a-rat-burn-wound-model
#18
Tiam M Saffari, Barthold N Schüttenhelm, Johan W van Neck, Jan C Holstege
In this study, we investigated whether post-burn itch in rats, after a full thickness burn, is correlated to the nervous reinnervation of the burn wound area. For this purpose, we determined scratching duration (expressed as sec/hr) at 24 hours, 2, 4, 8 and 12 weeks post-burn and combined this with immunohistochemistry for protein gene product 9.5 (PGP9.5) to identify all nerve fibers, calcitonin gene related peptide (CGRP) to identify peptidergic fibers, tyrosine hydroxylase (TH) for sympathetic fibers and growth-associated protein 43 (GAP-43) for regrowing fibers...
February 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29453360/role-of-intestinal-trefoil-factor-in-protecting-intestinal-epithelial-cells-from-burn-induced-injury
#19
Jianhong Hu, Yan Shi, Chao Wang, Hanxing Wan, Dan Wu, Hongyu Wang, Xi Peng
Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA and the underlying mechanisms. We found that ITF significantly stimulated intestinal glutamine transport in burned rats. Mechanistically, ITF enhanced autophagy, reduces endoplasmic reticulum stress (ERS), and alleviates the impaired PDI, ASCT2, and B0AT1 in IECs and BBMVs after burn injury likely through AMPK activation...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453224/simple-limbal-epithelial-transplantation-slet-in-failed-cultivated-limbal-epithelial-transplantation-clet-for-unilateral-chronic-ocular-burns
#20
Sayan Basu, Sashwanthi Mohan, Swapnil Bhalekar, Vivek Singh, Virender Sangwan
AIMS: Cultivated limbal epithelial transplantation (CLET) fails in around 20%-30% of cases. This study aimed to report the clinical outcomes of autologous simple limbal epithelial transplantation (SLET) in eyes with recurrent unilateral limbal stem cell deficiency (LSCD) due to failure of CLET. METHODS: This was a prospective case series which included 30 eyes of 30 patients who underwent SLET between 2010 and 2016 after failure of one (n=24) or two (n=6) previous CLET procedures for chronic unilateral ocular burns...
February 16, 2018: British Journal of Ophthalmology
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