Read by QxMD icon Read


Amanda Roxburgh, Wayne D Hall, Timothy Dobbins, Natasa Gisev, Lucinda Burns, Sallie Pearson, Louisa Degenhardt
BACKGROUND: There has been international concern over the rise in fatal pharmaceutical opioid overdose rates, driven by increased opioid analgesic prescribing. The current study aimed to examine trends in opioid overdose deaths by: 1) opioid type (heroin and pharmaceutical opioids); and 2) age, gender, and intent of the death assigned by the coroner. METHODS: Analysis of data from the National Coronial Information System (NCIS) of opioid overdose deaths occurring between 2001 and 2012...
August 14, 2017: Drug and Alcohol Dependence
Yingze Tian, Jiayuan Liu, Suqin Han, Xurong Shi, Guoliang Shi, Hong Xu, Haofei Yu, Yufen Zhang, Yinchang Feng, Armistead G Russell
Day and night PM2.5 samples were collected at coastal and inland stations in a megacity in China. Temporal, spatial, and directional characteristics of PM2.5 concentrations and compositions were investigated. Average PM2.5 concentration was higher at inland (153.28μg/m(3)) than at coastal (114.46μg/m(3)). PM2.5 were significantly influenced by season and site but insignificantly by diurnal pattern. Sources were quantified by a two-way and a newly developed three-way receptor models conducted using ME2. Secondary sulfate and SOC (SS&SOC, 25% and 23%), coal and biomass burning (CC&BB, 20% and 21%), crustal and cement dust (CRD&CED, 19% and 21%), secondary nitrate (SN, 13% and 18%), vehicular exhaust (VE, 14% and 17%), and sea salt (SEA, 6% and 2%) were major sources for coastal and inland...
August 10, 2017: Journal of Hazardous Materials
Lin Jiang, Jia-Jia He, Jin-Hua Sun
Upward flame spread has the same propagating direction with air flow and buoyancy, and features as the most hazardous fire case in all flame spread configurations. It has been a long time for fire researchers to find a simple and effective method to evaluate upward flame spread behaviors, especially for different materials and sample sizes. The aim of this work was motivated by the research of sample width and thickness effects on upward flame spread behavior, including flame spread rate during acceleration propagation for different sample thickness and width, theoretical global mass loss prediction based on Emmons's hypothesis, and dimensionless flame height scaling with dimensionless heat release rate for steady stage burning...
August 12, 2017: Journal of Hazardous Materials
Kenichiro Kita, Yoichiro Takata, Kosaku Higashino, Kazuta Yamashita, Fumitake Tezuka, Toshinori Sakai, Akihiro Nagamachi, Koichi Sairyo
Background  The major complication of percutaneous vertebroplasty (PVP) using polymethyl methacrylate (PMMA) is epidural leakage of PMMA that damages the spinal cord. Methods  This is a case report. Result  A 77-year-old man presented to our institution with a 6-month history of muscle weakness and an intolerable burning sensation of both lower limbs after PVP with PMMA for thoracic compression fracture at T7 at another hospital. His past medical history was significant for hypertension. He had no history of smoking and alcohol...
January 2017: Surg J (N Y)
Bilgin Keserci, Nguyen Minh Duc
BACKGROUND: To retrospectively compare the treatment success, therapeutic efficacy, and adverse effects of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) treatment for uterine fibroid patients with and without abdominal scars. METHODS: Seventy-six women who underwent treatment were divided into group 1 (patients with abdominal scars, which were covered with scar patches that prevents ultrasound energy from reaching the scar tissue immediately behind the patch) and group 2 (patients without abdominal scars)...
2017: Journal of Therapeutic Ultrasound
Daniel Saddawi-Konefka, Keith Baker, Anthony Guarino, Sara M Burns, Gabriele Oettingen, Peter M Gollwitzer, Jonathan E Charnin
BACKGROUND : Following through on one's goals to study is essential for effective, self-regulated learning. This can be difficult for residents because of clinical demands and limited personal time. WOOP (Wish, Outcome, Obstacle, Plan) is a self-regulation strategy, also known as mental contrasting with implementation intentions. WOOP increases follow-through on goals in many domains, although it has not, to our knowledge, been evaluated in medical education. OBJECTIVE : We compared the effect of WOOP versus goal setting on time residents spent studying...
August 2017: Journal of Graduate Medical Education
Niely Mirsaidi, Matthew P Burns, Steve A McClain, Edward Forsyth, Jonathan Li, Brittany Dukes, David Lin, Roxanna Nahvi, Jheison Giraldo, Megan Patton, Ping Wang, Ke Lin, Edmund Miller, Timothy Ratliff, Sayyed Hamidi, Scott Crist, Ken-Ichi Takemaru, Anthony Szema
To identify if the absence of the vasoactive intestinal peptide (VIP) gene enhances susceptibility to death from metastatic bladder cancer, two strains of mice were injected with MB49 murine bladder cancer cells. The growth and spread of the cancer was measured over a period of 4 weeks in C57BL/6 mice and 5 weeks in VIP knockout (KO) mice. A Kaplan-Meier plot was constructed to compare control C57BL/6 mice and C57BL/6 mice with MB49 vs. VIP KO controls and VIP KO mice with MB49. The wild-type (WT) strain (C57BL/6) contained the VIP gene, while the other strain, VIP knockout backcrossed to C57BL/6 (VIP KO) did not and was thus unable to endogenously produce VIP...
2017: Frontiers in Endocrinology
Uday Yanamandra, Uma Nahar Saikia, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra, Subhash Varma
A 32-years-old male developed exfoliating skin lesions in bilateral axillae and groins on D-42 post matched sibling allogeneic transplant. These lesions masqueraded betadine burns with a positive history of betadine application in the affected regions. He gradually developed lesions involving other parts of the body with Glucksberg grade-IV acute GVHD (skin-stage: IV/gut-stage: III). He succumbed to his illness. We present this case to highlight the rare initial presentation of skin GVHD involving localized body regions with sparing of rest of the body and mimicking betadine burns...
September 2017: Indian Journal of Hematology & Blood Transfusion
Ryan D Burns, You Fu, Leslie W Podlog
The purpose of this meta-analysis was to examine the effectiveness of school-based physical activity interventions on increasing students' physical activity enjoyment. An internet search with several databases using the keywords "Adolescents", "Children", "Enjoyment", "Physical Activity", and "Schools" was performed yielding over 200 published studies. Studies were eliminated based on the lack of experimental manipulation (i.e., non-intervention studies), no assessment of physical activity enjoyment as an outcome variable, a lack of a control or comparison group, and no reporting of the effect estimate's variability (i...
August 16, 2017: Preventive Medicine
Qibing Zeng, Peng Luo, Junying Gu, Bing Liang, Qizhan Liu, Aihua Zhang
Arsenic poisoning is a worldwide endemic disease that affects thousands of people. Growing evidence from animal, cell, and human studies indicates that arsenic has deleterious effects on the immune system. The present investigation is a population-based study that observed changes in the proliferation of human T-cells and IL-2 and INF-γ mRNA expression. Our results show that coal-burning arsenic can cause T-cell immunosuppression in the population, and participates in the occurrence and development of arsenic poisoning...
August 12, 2017: Environmental Toxicology and Pharmacology
Karun V Sharma, Pavel S Yarmolenko, Haydar Celik, Avinash Eranki, Ari Partanen, Anilawan Smitthimedhin, Aerang Kim, Matthew Oetgen, Domiciano Santos, Janish Patel, Peter Kim
OBJECTIVE: To evaluate clinical feasibility and safety of magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) treatment of symptomatic osteoid osteoma and to compare clinical response with standard of care treatment. STUDY DESIGN: Nine subjects with radiologically confirmed, symptomatic osteoid osteoma were treated with MR-HIFU in an institutional review board-approved clinical trial. Treatment feasibility and safety were assessed. Clinical response was evaluated in terms of analgesic requirement, visual analog scale pain score, and sleep quality...
August 11, 2017: Journal of Pediatrics
R Kandiyali, J H Sarginson, L I Hollén, F Spickett-Jones, A E R Young
The objective of this economic study was to evaluate the resource use and cost associated with the management of small area burns, including the additional costs associated with unexpected illness after burn in children of less than five years of age. This study was conducted as a secondary analysis of a multi-centre prospective observational cohort study investigating the physiological response to burns in children. 452 children were included in the economic analysis (median age=1.60years, 61.3% boys, median total burn surface area [TBSA]=1...
August 17, 2017: Burns: Journal of the International Society for Burn Injuries
Youlai Zhang, Yuanlin Zeng, Guohua Xin, Lijin Zou, Yuewei Ding, Jiang Duyin
OBJECTIVE: In the field of burns repairs, many problems exist in the shortage of donor skin, the expense of allograft or xenograft skin, temporary substitution and unsatisfactory extremity function after wound healing. Previous studies showed that burn-denatured skin could return to normal dermis formation and function. This study investigates the application of laser micro-pore burn-denatured acellular dermis matrix (DADM) from an escharotomy in the repair of burn wounds and evaluates the biological properties and wound repair effects of DADM in implantation experiments in Kunming mice...
August 17, 2017: Burns: Journal of the International Society for Burn Injuries
Laura Fuentes, Beatriz Duguy, Daniel Nadal-Sala
Since the 1970s, fire regimes have been modified in the Northern Mediterranean region due to profound landscape changes mostly driven by socioeconomic factors, such as rural abandonment and large-scale plantations. Both fuel accumulation and the increasing vegetation spatial continuity, combined with the expansion of the wildland-urban interface, have enhanced fire risk and the occurrence of large wildfires. This situation will likely worsen under the projected aridity increase resulting from climate change...
August 17, 2017: Science of the Total Environment
Xinying Wang, Jianbo Yang, Feng Tian, Li Zhang, Qiucheng Lei, Tingting Jiang, Jihong Zhou, Siming Yuan, Jun Wang, Zhijian Feng, Jieshou Li
PURPOSE: This time series experiments aimed to investigate the dynamic change of gut microbiomes after severe burn and its association with enteral nutrition (EN). MATERIALS AND METHODS: Seven severely burned patients who suffered from a severe metal dust explosion injury were recruited in this study. The dynamic changes of gut microbiome of fecal samples at six time points (1-3days, 2, 3, 4, 5 and 6weeks after severe burn) were detected using 16S ribosomal RNA pyrosequencing technology...
August 12, 2017: Journal of Critical Care
Isha Kaul, Ami Amin, Marta Rosenberg, Laura Rosenberg, Walter J Meyer
INTRODUCTION: Pruritis after burn is one of the most common chronic complaints in burn survivors. Pruritus is often indistinguishable from neuropathic pain. There is a paucity of studies reporting the use of gabapentin and pregabalin to treat both pruritus and neuropathic pain. The purpose of this current study is to explore and document the effect of gabapentin and pregabalin in children and adolescent burn survivors. METHODS: A retrospective review of charts and pharmacy records of gabapentin and pregabalin dispensed to control pruritus and/or pain was conducted for burn survivors up to 20 years of age...
August 16, 2017: Burns: Journal of the International Society for Burn Injuries
Gina Kim, Jeffrey Young
Corticosteroids play an important role in responding to physiologic stress in the human body. However, its application in critical care remains heavily debated. The purpose of this study was to identify patient characteristics associated with receiving stress-dose steroids during the intensive care unit stay after traumatic injury and its effect on in-hospital mortality. Patients admitted to the University of Virginia trauma center between January 1, 2011, and December 31, 2015, were identified using our Trauma Registry...
August 1, 2017: American Surgeon
Yan Li, Damien Sulla-Menashe, Safa Motesharrei, Xiao-Peng Song, Eugenia Kalnay, Qing Ying, Shuangcheng Li, Zongwen Ma
The Chinese National Forest Inventory (NFI) has reported increased forest coverage in China since 2000, however, the new satellite-based dataset Global Forest Change (GFC) finds decreased forest coverage. In this study, four satellite datasets are used to investigate this discrepancy in forest cover change estimates in China between 2000 and 2013: forest cover change estimated from MODIS Normalized Burn Ratio (NBR), existing MODIS Land Cover (LC) and Vegetation Continuous Fields (VCF) products, and the Landsat-based GFC...
August 18, 2017: Scientific Reports
Lin Zeng, Brinta Chakraborty, Tanaz Farivar, Robert A Burne
The glucose/mannose-PTS permease EII(Man) encoded by manLMN in the dental caries pathogen Streptococcus mutans has a dominant influence on sugar-specific, CcpA-independent catabolite repression (CR). Mutations in manL affect energy metabolism and virulence-associated traits, including biofilm formation, acid tolerance and competence. Using promoter:reporter fusions, expression of the manLMN and the fruRKI operons, encoding a transcriptional regulator, a fructose-1-P kinase and a fructose-PTS permease EII(Fru), respectively, was monitored in response to carbohydrate source and in mutants lacking CcpA, FruR, and components of EII(Man) Expression of genes for EII(Man) and EII(Fru) was directly regulated by CcpA and CR, as evinced by in vivo and in vitro methods...
August 18, 2017: Applied and Environmental Microbiology
Hanneke N Monsuur, Lenie J van den Broek, Renushka L Jhingoerie, Adrianus F P M Vloemans, Susan Gibbs
The majority of full-thickness burn wounds heal with hypertrophic scar formation. Burn eschar most probably influences early burn wound healing, since granulation tissue only forms after escharotomy. In order to investigate the effect of burn eschar on delayed granulation tissue formation, burn wound extract (BWE) was isolated from the interface between non-viable eschar and viable tissue. The influence of BWE on the activity of endothelial cells derived from dermis and adipose tissue, dermal fibroblasts and adipose tissue-derived mesenchymal stromal cells (ASC) was determined...
August 18, 2017: International Journal of Molecular Sciences
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"