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https://www.readbyqxmd.com/read/29913375/versatile-graphene-biosensors-for-enhancing-human-cell-therapy
#1
REVIEW
George M Vlăsceanu, Roxana-Maria Amărandi, Mariana Ioniță, Teddy Tite, Horia Iovu, Luisa Pilan, Jorge S Burns
Technological advances in engineering and cell biology stimulate novel approaches for medical treatment, in particular cell-based therapy. The first cell-based gene therapy against cancer was recently approved by the US Food and Drug Administration. Progress in cancer diagnosis includes a blood test detecting five cancer types. Numerous stem cell phase I/II clinical trials showing safety and efficacy will soon pursue qualifying criteria for advanced therapy medicinal products (ATMP), aspiring to join the first stem-cell therapy approved by the European Medicines Agency...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29913367/carbon-and-nitrogen-isotopes-unravels-sources-of-aerosol-contamination-at-caribbean-rural-and-urban-coastal-sites
#2
Yasser Morera-Gómez, Jesús Miguel Santamaría, David Elustondo, Carlos Manuel Alonso-Hernández, David Widory
The constant increase of anthropogenic emissions of aerosols, usually resulting from a complex mixture from various sources, leads to a deterioration of the ambient air quality. The stable isotope compositions (δ13 C and δ15 N) of total carbon (TC) and nitrogen (TN) in both PM10 and emissions from potential sources were investigated for first time in a rural and an urban Caribbean costal sites in Cuba to better constrain the origin of the contamination. Emissions from road traffic, power plant and shipping emissions were discriminated by coupling their C and N contents and corresponding isotope signatures...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29913093/recent-advances-in-the-etiology-and-treatment-of-burning-mouth-syndrome
#3
A Ritchie, J M Kramer
Burning mouth syndrome (BMS) is a debilitating condition that has a striking female predilection. Although the oral mucosa is normal in appearance, patients with BMS experience oral burning that most commonly localizes to the lips and tongue. BMS is a diagnosis of exclusion, and all underlying pathoses associated with allodynia must be ruled out prior to rendering the diagnosis. The etiopathogenesis of BMS remains poorly understood, and thus patient management is challenging. Data indicate that oral and systemic factors both contribute to the development and persistence of the condition...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29912941/structural-definition-of-hsp-d-recognition-of-salmonella-enterica-lps-inner-core-oligosaccharides-reveals-alternative-binding-modes-for-the-same-lps
#4
Jamie R Littlejohn, Ruben F da Silva, William A Neale, Carrie C Smallcombe, Howard W Clark, Rose-Marie A Mackay, Alastair S Watson, Jens Madsen, Derek W Hood, Ian Burns, Trevor J Greenhough, Annette K Shrive
The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mutant chemotypes Rc and Rd1) have been determined. The structures reveal that hSP-D specifically and preferentially targets the LPS inner core via the innermost conserved Hep-Kdo pair with the flexibility for alternative recognition when this preferred epitope is not available for binding...
2018: PloS One
https://www.readbyqxmd.com/read/29912565/electronic-structure-and-enhanced-charge-density-wave-order-of-monolayer-vse-sub-2-sub
#5
Jiagui Feng, Deepnarayan Biswas, Akhil Rajan, Matthew D Watson, Federico Mazzola, Oliver J Clark, Kaycee Underwood, Igor Marković, Martin McLaren, Andrew Hunter, David Michael Burn, Liam Duffy, Sourabh Barua, Geetha Balakrishnan, Francois Bertran, Patrick Le Fevre, Timur Kim, Gerrit van der Laan, Thorsten Hesjedal, Peter Wahl, Phil D C King
How the interacting electronic states and phases of layered transition-metal dichalcogenides evolve when thinned to the single-layer limit is a key open question in the study of two-dimensional materials. Here, we use angle-resolved photoemission to investigate the electronic structure of monolayer VSe<sub>2</sub> grown on bi-layer graphene/SiC. While the global electronic structure is similar to that of bulk VSe<sub>2</sub>, we show that, for the monolayer, pronounced energy gaps develop over the entire Fermi surface with decreasing temperature below T<sub>c</sub>=140±5 K, concomitant with the emergence of charge-order superstructures evident in low-energy electron diffraction...
June 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29911529/techniques-for-optimizing-surgical-scars-part-3-erythema-hyperpigmentation-and-hypopigmentation
#6
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 3 focuses on scar revision for erythema, hyperpigmentation, and hypopigmentation. Scar revision options for erythematous scars include moist exposed burn ointment (MEBO), onion extract, silicone, methyl aminolevulinate-photodynamic therapy (MAL-PDT), pulsed dye laser, intense pulsed light (IPL), and nonablative fractional lasers...
2018: Skinmed
https://www.readbyqxmd.com/read/29911087/retrospective-study-to-evaluate-the-treatment-of-digital-pulp-lesions-using-a-homodigital-flap
#7
Tarsila Pagnan Silva Dos Santos, Marcelo Tavares de Oliveira, Luiz Carlos Angelini
Objective: To assess the homodigital flap surgical procedure, as well as the function of the finger, pain, sensation, esthetics, and patient satisfaction. Method: Retrospective analysis of records and questionnaires of patients who underwent this surgical technique between the months of May 2013 and October 2016. Eight were included in the study, with an average follow-up period of 23 months. Patients with digital pulp lesions of the thumbs and those who did not perform rehabilitation were excluded...
March 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29910163/prostatic-artery-embolization-with-250-%C3%AE-m-spherical-polyzene-coated-hydrogel-microspheres-for-lower-urinary-tract-symptoms-with-follow-up-mr-imaging
#8
Tobias Franiel, René Aschenbach, Sarah Trupp, Thomas Lehmann, Friedrich-Carl von Rundstedt, Marc-Oliver Grimm, Ulf Teichgräber
PURPOSE: To evaluate clinical outcomes and possible MR imaging predictors of clinical success after prostatic artery embolization (PAE) with 250-μm hydrogel particles. MATERIALS AND METHODS: During a span of 1.5 years, 30 patients with moderate to severe lower urinary tract symptoms were included in a prospective, nonrandomized study. Embolization of at least one prostatic artery was considered as technical success. International Prostate Symptom Score (IPSS), quality of life (QOL), peak urinary flow rate (Qmax ), residual urine volume, prostate volume, prostate-specific antigen level, and International Index of Erectile Function (IIEF) were recorded at baseline and at 1, 3, and 6 months after PAE...
June 14, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29910064/source-apportionment-of-pm-10-and-pm-2-5-air-pollution-and-possible-impacts-of-study-characteristics-in-south-korea
#9
Hyoung Gon Ryou, Jongbae Heo, Sun-Young Kim
INTRODUCTION: Studies of source apportionment (SA) for particulate matter (PM) air pollution have enhanced understanding of dominant pollution sources and quantification of their contribution. Although there have been many SA studies in South Korea over the last two decades, few studies provided an integrated understanding of PM sources nationwide. The aim of this study was to summarize findings of PM SA studies of South Korea and to explore study characteristics. METHODS: We selected studies that estimated sources of PM10 and PM2...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29909680/prevention-of-iatrogenic-chemical-burns-during-tourniquet-controlled-hand-surgery
#10
M Horner, R W Trickett
No abstract text is available yet for this article.
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909537/existing-agricultural-ecosystem-in-china-leads-to-environmental-pollution-an-econometric-approach
#11
Lei Hongdou, Li Shiping, Li Hao
Sustainable agriculture ensures food security and prevents starvation. However, the need to meet the increasing food demands of the growing population has led to poor and unsustainable agricultural practices, which promote environmental degradation. Given the contributions of agricultural ecosystems to environmental pollution, we investigated the impact of the agricultural ecosystem on environmental pollution in China using time series data from 1960 to 2014. We employed several methods for econometric analysis including the unit root test, Johansen test of cointegration, Granger causality test, and vector error correction model...
June 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909321/spatio-temporal-variations-in-so-2-and-no-2-emissions-caused-by-heating-over-the-beijing-tianjin-hebei-region-constrained-by-an-adaptive-nudging-method-with-omi-data
#12
Kai Meng, Xiangde Xu, Xinghong Cheng, Xiaobin Xu, Xiaoli Qu, Wenhui Zhu, Cuiping Ma, Yuling Yang, Yuguang Zhao
The Beijing-Tianjin-Hebei (BTH) region in China suffers from heavy air pollution, especially in heating period. SO2 and NO2 are two of the key primary gaseous pollutants emitted by coal burning. The increase in air pollution caused by heating in the south-central part of the BTH region is higher than that in the northern part. And the distribution of SO2 and NO2 increment has significant differences. In this work, SO2 and NO2 emissions over the BTH region are determined using an adaptive "nudging" constrained method and a variational processing technique based on Ozone Monitoring Instrument (OMI) satellite data and surface measurement data collected in 2015...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909310/comparison-of-pm-2-5-chemical-composition-and-sources-at-a-rural-background-site-in-central-europe-between-1993-1994-1995-and-2009-2010-effect-of-legislative-regulations-and-economic-transformation-on-the-air-quality
#13
Petra Pokorná, Jaroslav Schwarz, Radovan Krejci, Erik Swietlicki, Vladimír Havránek, Vladimír Ždímal
From December 1993 to January 1995 and from October 2009 to October 2010, a total of 320 and 365 daily samples of the PM2.5 were collected at a rural background site (National Atmospheric Observatory Košetice) in Central Europe. The PM2.5 samples were analyzed for 29 and 26 elements respectively by Particle-Induced X-ray Emission (PIXE) and water-soluble inorganic ions by Ion Chromatography (IC) in 2009/2010. The Positive Matrix Factorization (PMF) was applied to the chemical composition of PM2.5 to determine its sources...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29909307/a-comparison-of-various-approaches-used-in-source-apportionments-for-precipitation-nitrogen-in-a-mountain-region-of-southwest-china
#14
Jian Cui, Fengwu Zhou, Min Gao, Liuyi Zhang, Leiming Zhang, Ke Du, Qiangmei Leng, Yuanzhu Zhang, Dongyi He, Fumo Yang, Andy Chan
Six different approaches are applied in the present study to apportion the sources of precipitation nitrogen making use of precipitation data of dissolved inorganic nitrogen (DIN, including NO3 - and NH4 + ), dissolved organic nitrogen (DON) and δ15 N signatures of DIN collected at six sampling sites in the mountain region of Southwest China. These approaches include one quantitative approach running a Bayesian isotope mixing model (SIAR model) and five qualitative approaches based on in-situ survey (ISS), ratio of NH4 + /NO3 - (RN ), principal component analysis (PCA), canonical-correlation analysis (CCA) and stable isotope approach (SIA)...
June 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29908752/impact-of-encapsulation-on-in-vitro-and-in-vivo-performance-of-volatile-nanoscale-phase-shift-perfluorocarbon-droplets
#15
Kimoon Yoo, Wesley R Walker, Ross Williams, Charles Tremblay-Darveau, Peter N Burns, Paul S Sheeran
Phase-shift droplets can be converted by sound from low-echogenicity, liquid-core agents into highly echogenic microbubbles. Many proposed applications in imaging and therapy take advantage of the high spatiotemporal control over this dynamic transition. Although some studies have reported increased circulation time of the droplets compared with microbubbles, few have directly explored the impact of encapsulation on droplet performance. With the goal of developing nanoscale droplets with increased circulatory persistence, we first evaluate the half-life of several candidate phospholipid encapsulations in vitro at clinical frequencies...
June 13, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29908577/traditional-and-ethnobotanical-dermatology-practices-in-africa
#16
Ncoza C Dlova, Moses A Ollengo
More than 80% of the global population depends on traditional medicine for their basic primary health care needs. Africa has a well-established history of botanicals use. These include a vast array of compounds that can be used to treat various skin-related conditions. The rationale for the use of traditional medicine in skincare stems from the physical effects these compounds have on skin, such as the ability to control bleeding and speed up wound healing, as well as the potential to treat burns and other disorders of pigmentation...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29907755/molecular-chaperoning-helps-safeguarding-mitochondrial-integrity-and-motor-functions-in-the-sahara-silver-ant-cataglyphis-bombycina
#17
Quentin Willot, Patrick Mardulyn, Matthieu Defrance, Cyril Gueydan, Serge Aron
The Sahara silver ant Cataglyphis bombycina is one of the world's most thermotolerant animals. Workers forage for heat-stricken arthropods during the hottest part of the day, when temperatures exceed 50 °C. However, the physiological adaptations needed to cope with such harsh conditions remain poorly studied in this desert species. Using transcriptomics, we screened for the most heat-responsive transcripts of C. bombycina with aim to better characterize the molecular mechanisms involved with macromolecular stability and cell survival to heat-stress...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907587/precision-prevention-and-early-detection-of-cancer-fundamental-principles
#18
Timothy R Rebbeck, Karen Burns-White, Andrew T Chan, Karen Emmons, Matthew Freedman, David J Hunter, Peter Kraft, Francine Laden, Lorelei Mucci, Giovanni Parmigiani, Deborah Schrag, Sapna Syngal, Rulla M Tamimi, Kasisomayajula Viswanath, Matthew B Yurgelun, Judy E Garber
Prevention and early detection is critical for reducing the population cancer burden. Two approaches have been used: Population approaches change social norms (e.g., smoking bans) or impose incentives (e.g., cigarette taxes); high-risk strategies intervene upon individuals with elevated cancer risk (e.g., smoking cessation). Knowledge about carcinogenesis mechanisms, extreme exposures, and inherited susceptibility provides opportunities to develop precision prevention and early-detection (PPED) strategies. PPED aims to understand the basis of risk, identify groups that optimally benefit from interventions, characterize heterogeneity in intervention responses, optimize intervention timing, and minimize toxicities...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907407/comparative-risk-assessment-of-oil-spill-response-options-for-a-deepwater-oil-well-blowout-part-ii-relative-risk-methodology
#19
Michael Bock, Hilary Robinson, Richard Wenning, Deborah French-McCay, Jill Rowe, Ann Hayward Walker
Subsea dispersant injection (SSDI) was a new oil spill response (OSR) technology deployed during the Deepwater Horizon accident. To integrate SSDI into future OSR decisions, a hypothetical deepwater oil spill to the Gulf of Mexico was simulated and a comparative risk assessment (CRA) tool applied to contrast three response strategies: (1) no intervention; (2) mechanical recovery, in-situ burning, and surface dispersants; and, (3) SSDI in addition to responses in (2). A comparative ecological risk assessment (CRA) was applied to multiple valued ecosystem components (VECs) inhabiting different environmental compartments (ECs) using EC-specific exposure and relative VEC population density and recovery time indices...
June 12, 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29907353/determinants-of-skeletal-muscle-protein-turnover-following-severe-burn-trauma-in-children
#20
Ioannis Malagaris, David N Herndon, Efstathia Polychronopoulou, Victoria G Rontoyanni, Clark R Andersen, Oscar E Suman, Craig Porter, Labros S Sidossis
BACKGROUND & AIMS: Burns remain the fifth cause of non-fatal pediatric injuries globally, with muscle cachexia being a hallmark of the stress response to burns. Burn-induced muscle wasting is associated with morbidity, yet the determinants of muscle protein catabolism in response to burn trauma remains unclear. Our objective was to determine the effect of patient and injury characteristics on muscle protein kinetics in burn patients. METHODS: This retrospective, observational study was performed using protein kinetic data from pediatric patients who had severe burns (>30% of the total body surface area burned) and underwent cross-limb stable isotope infusions between 1999 and 2008 as part of prospective clinical trials...
June 4, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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