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Early pregnancy management

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https://www.readbyqxmd.com/read/28420497/radical-trachelectomy-for-early-stage-cervical-cancer-a-case-series-and-literature-review
#1
Chin-Jui Wu, Wen-Chun Chang, Chi-Hau Chen, Chi-An Chen, Su-Cheng Huang, Bor-Ching Sheu
OBJECTIVE: Radical trachelectomy (RT) is an alternative treatment for preserving fertility in patients with cervical cancer. Because women with operable cervical cancer opting for fertility preservation are scarce, few cases have been reported in Taiwan. Here we report our cases series. MATERIALS AND METHODS: We retrospectively evaluated seven patients who underwent vaginal RT and three patients who underwent abdominal RT in a single medical institute for a median follow-up period of 5 years...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28418209/acupressure-as-adjuvant-treatment-for-the-inpatient-management-of-nausea-and-vomiting-in-early-pregnancy-a-double-blind-randomized-controlled-trial
#2
Aizura-Syafinaz Adlan, Kar Yoke Chooi, Noor Azmi Mat Adenan
AIM: To evaluate the efficacy of acupressure at the Neiguan point (Pericardium [P]6) as adjuvant treatment during inpatient management of severe nausea and vomiting in pregnancy. METHODS: Low risk, spontaneously conceived singleton pregnancies were randomly assigned to a treatment group, who received an acupressure band placed at the Neiguan point (P6) or a placebo group who received an otherwise identical non-stimulating wristband. Participants wore the band for 12 h daily for the first three days of admission...
April 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28414788/patients-with-subclinical-hypothyroidism-before-20-weeks-of-pregnancy-have-a-higher-risk-of-miscarriage-a-systematic-review-and-meta-analysis
#3
Yibing Zhang, Haoyu Wang, Xifeng Pan, Weiping Teng, Zhongyan Shan
OBJECTIVE: To evaluate the relationship between subclinical hypothyroidism (SCH) and the risk of miscarriage before 20 weeks of pregnancy. METHODS: Literature databases were searched, including the PubMed, Web of Science, Embase and Cochrane databases, from January 1, 1980, to December 31, 2015. The following search terms were used: subclinical hypothyroidism, hypothyroidism, thyroid dysfunction, thyroid hypofunction, subclinical thyroid disease, thyroid dysfunction, pregnancy loss, abortion and miscarriage...
2017: PloS One
https://www.readbyqxmd.com/read/28412876/effect-of-breastfeeding-on-postpartum-depressive-symptoms-among-adolescent-and-young-adult-mothers
#4
Heather L Sipsma, Elizabeth Ruiz, Krista Jones, Urania Magriples, Trace Kersahw
PURPOSE: To describe the association between breastfeeding and postpartum depressive symptoms among a sample of adolescent and young adult mothers and to determine whether breastfeeding difficulty moderates this association. MATERIALS AND METHODS: Data were derived from a prospective cohort of pregnant adolescent and young adult females (ages 14-21) as they transitioned to parenthood. This analysis uses data collected during pregnancy and at 6 months postpartum among mothers (n = 137) who initiated breastfeeding...
April 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28406529/validation-of-the-biopryn-enzyme-linked-immunosorbent-assay-for-detection-of-pregnancy-specific-protein-b-pspb-and-diagnosis-of-pregnancy-in-american-bison-bison-bison
#5
D M Love, M T Mefford, J C Ramer
This study assessed the accuracy of the commercial BioPRYN(®) ELISA for the detection of pregnancy-specific protein-B (PSPB) using a single blood sample to determine pregnancy status in American bison (Bison bison). A total of 49 bison cows were used in the study, and sampled at two time-points during the gestation period, fall and spring, correlating with early- to mid-term gestation (average 62.9 days post-mating) and mid- to late-term gestation (average 229.2 days post-mating), respectively. Sensitivity of the test during early- to mid-term gestation sampling period (fall) was 87...
April 12, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28402956/elevated-dietary-magnesium-during-pregnancy-and-postnatal-life-prevents-ectopic-mineralization-in-enpp1asj-mice-a-model-for-generalized-arterial-calcification-of-infancy
#6
Joshua Kingman, Jouni Uitto, Qiaoli Li
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder caused by mutations in the ENPP1 gene. It is characterized by mineralization of the arterial blood vessels, often diagnosed prenatally, and associated with death in early childhood. There is no effective treatment for this devastating disorder. We previously characterized the Enpp1asjmutant mouse as a model of GACI, and we have now explored the effect of elevated dietary magnesium (five-fold) in pregnant mothers and continuing for the first 14 weeks of postnatal life...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399133/establishment-of-reference-intervals-during-normal-pregnancy-through-six-months-postpartum-in-western-kenya
#7
Collins Odhiambo, Paul Omolo, Boaz Oyaro, John Williamson, John Kinuthia, Daniel Matemo, Alison Drake, Grace John-Stewart, Clement Zeh
BACKGROUND: Pregnancy is associated with changes in hematological and biochemistry values, yet there are no African reference intervals for clinical management of pregnant women. We sought to 1) develop laboratory reference intervals during pregnancy and up to 24 weeks postpartum and 2) determine the proportion of women in a previous clinical trial who would be misclassified as having out-of-range values using reference intervals from a United States (U.S.) population. METHODS AND FINDINGS: This was a longitudinal sub-study of 120 clinically healthy, HIV-uninfected, self-selected pregnant women seeking antenatal care services at either of two public hospitals in western Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28397629/the-impact-of-life-stress-on-adult-depression-and-anxiety-is-dependent-on-gender-and-timing-of-exposure
#8
Carly E Herbison, Karina Allen, Monique Robinson, John Newnham, Craig Pennell
There is debate about the relative importance of timing of stressful events prenatally and over the life course and risk for subsequent depressive/anxious illness. The aim of this study was to examine the relative roles of prenatal stress and postnatal stress trajectories in predicting depression and anxiety in early adulthood in males and females. Exposure to life stress events was examined in the Western Australian Pregnancy Cohort (Raine) Study during pregnancy and ages 1, 2, 3, 5, 8, 10, 14, and 17 years...
April 11, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28395924/correction-correction-to-clinical-policy-critical-issues-in-the-initial-evaluation-and-management-of-patients-presenting-to-the-emergency-department-in-early-pregnancy-annals-of-emergency-medicine-69-2017-241-250-e20
#9
Sigrid A Hahn, Susan B Promes, Michael D Brown
Due to a miscommunication during the process of transferring this manuscript from our editorial team to Production, the Members of the American College of Emergency Physicians Clinical Policies Committee (Oversight Committee) were not properly indexed in PubMed. This has now been corrected online. The publisher would like to apologize for any inconvenience caused.
April 7, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28392223/obstetric-care-in-women-with-genetic-disorders
#10
REVIEW
Shilpa Chetty, Mary E Norton
The management of pregnant women who are themselves affected with genetic diseases is an increasingly relevant and important issue. Improvements in early diagnosis and management of genetic disease, as well as advances in assisted reproductive technology have impacted pregnancy rates in a cohort of women who may not have otherwise been able to conceive. A multidisciplinary approach is key to the management of pregnant women with complex health conditions, including genetic diseases. Pertinent issues should be addressed in the preconception, antepartum, intrapartum and postpartum periods to optimize maternal and fetal health...
March 18, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28385397/maternal-age-modulates-the-effects-of-early-pregnancy-l-proline-supplementation-on-the-birth-weight-of-piglets
#11
P Gonzalez-Añover, A Gonzalez-Bulnes
Previous results obtained in gilts maintained under experimental conditions suggest that amino acid supplementation during pregnancy may be a promising strategy for diminishing the incidence of embryo losses and low birth-weight newborn. The current study evaluated the effects of a short-term supplementation with L-proline, around implantational stages, on litter size and birth-weight of piglets in sows of different parities maintained under commercial farm conditions. There were no significant effects in mature sows with three or more parities, but the supplementation improved the reproductive efficiency of the high-prolific first-parity sows and of all the sows at second-parity...
March 30, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28372936/-every-person-s-just-different-women-s-experiences-with-counseling-for-early-pregnancy-loss-management
#12
Robin Wallace, Angela DiLaura, Christine Dehlendorf
BACKGROUND: Women have strong preferences for their choice of early pregnancy loss (EPL) management. However, current practice patterns suggest that some women may not be offered counseling about the full range of management options. To develop a foundation for quality counseling about EPL treatment, we elicited patients' perspectives regarding their preferences and values for communication during this decision-making process. METHODS: Twenty-one individual interviews were conducted with women who recently experienced EPL...
March 31, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28367735/severe-vivax-malaria-a-prospective-exploration-at-a-tertiary-healthcare-centre-in-southwestern-india
#13
Rishikesh Kumar, Kavitha Saravu
Plasmodium vivax is recognized to cause severe malaria and mortality. We aimed to determine the proportion of disease severity, the spectrum of complications, underlying non-infectious comorbidities and predictors of severity in monoinfection P. vivax malaria among adults at a tertiary healthcare centre in Southwestern India. A prospective cohort study was conducted among microscopically confirmed monoinfection P. vivax acute malaria patients aged, ≥18 years. Cases with pregnancy and concomitant febrile illnesses including mixed malaria were excluded...
April 3, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28366413/adverse-effects-of-female-obesity-and-interaction-with-race-on-reproductive-potential
#14
REVIEW
Barbara Luke
Across the reproductive spectrum, obesity is associated with greater risks for adverse health outcomes, including higher rates of infertility, subfertility, early pregnancy loss, fetal deaths and stillbirths, congenital anomalies, and pregnancy complications. The excess reproductive morbidity associated with obesity may increase with longer duration, making the current trends among children and young adults particularly critical in terms of their future reproductive potential. Obese women have a lower chance of pregnancy following in vitro fertilization (IVF), require higher dosages of gonadotropins, and have reduced rates of implantation, clinical intrauterine gestation, and live birth rates and increased rates of pregnancy loss, as well as greater risks for prematurity and preeclampsia even when stratified by plurality...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28361555/life-threatening-endocrine-emergencies-during-pregnancy-management-and-therapeutic-features
#15
Birgit Harbeck, Amir-Hossein Rahvar, Sven Danneberg, Morten Schütt, Friedhelm Sayk
Endocrine emergencies during pregnancy may be life-threatening events for both mother and fetus. Besides pregnancy-associated endocrine disorders, several pre-existing endocrinopathies such as type-1 diabetes and Grave's disease or adrenal failure may acutely deteriorate during pregnancy. Since "classical" signs are often modified by pregnancy, early diagnosis and management may be hampered. In addition, laboratory tests show altered physiologic ranges and pharmacologic options are limited while therapeutic goals are mostly tighter than in the non-pregnant patient...
March 31, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28361296/women-with-homozygous-at-deficiency-type-ii-heparin-binding-site-hbs-are-at-high-risk-of-pregnancy-loss-and-pregnancy-complications
#16
Julia Kraft, Raute Sunder-Plassmann, Christine Mannhalter, Peter Quehenberger, Gernot Tews, Martin Langer, Ingrid Pabinger
Data regarding outcome and therapy of pregnancies in patients with homozygous antithrombin (AT) deficiency are very rare. We conducted a retrospective, descriptive investigation with emphasis on the obstetric history of eight women with homozygous AT deficiency heparin-binding site (HBS), who had at least one pregnancy. The aim of the study was to get a better insight into the outcome and identify suitable management procedures of pregnancy in this rare disease. All patients suffered from homozygous AT deficiency caused by the mutation c...
March 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28356062/successful-multigravid-pregnancy-in-a-42-year-old-patient-on-continuous-ambulatory-peritoneal-dialysis-and-a-review-of-the-literature
#17
Thiam Seong Christopher Lim, Malini Shanmuganathan, Irene Wong, Bak Leong Goh
BACKGROUND: For peritoneal dialysis patients, the likelihood of conception is low and the probability of getting through the pregnancy successfully is even lower. Almost 60 years after the first reported case of a successful pregnancy in a dialysis patient, many issues concerning pregnancy in dialysis patients remain unresolved. Our patient's pregnancy is considered high risk as she has end stage renal failure and falls in the category of advance maternal age for pregnancy. We describe here the course of her uneventful pregnancy which we hope will contribute to the overall knowledge and management of pregnancy in elderly patients receiving peritoneal dialysis...
March 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28346766/maternal-thyroid-parameters-in-pregnant-women-with-different-ethnic-backgrounds-do-ethnicity-specific-reference-ranges-improve-the-diagnosis-of-subclinical-hypothyroidism
#18
Flora Veltri, Julie Belhomme, Pierre Kleynen, Lidia Grabczan, Serge Rozenberg, Thierry Pepersack, Kris Poppe
OBJECTIVE: Guidelines on the management of thyroid dysfunction during pregnancy have recently been updated and, for the diagnosis of subclinical hypothyroidism (SCH), a TSH upper reference limit (cutoff) of 4.0 mIU/L has been proposed when no institutional values are available. It is also suggested that serum TSH and thyroid autoimmunity (TAI) may be different according to the ethnic background of the women. We therefore determined the prevalence of TAI and SCH in pregnant women with different ethnic backgrounds and, to define SCH, we used different first trimester TSH upper reference cutoffs (institutional, ethnicity-specific, 2...
March 27, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28345398/challenges-in-the-surgical-management-of-ectopic-pregnancy-in-a-low-resource-setting-mpilo-central-hospital-bulawayo-zimbabwe
#19
Solwayo Ngwenya
Background Ectopic pregnancy contributes to maternal morbidity and mortality, especially in low-resourced countries with limited facilities for early diagnosis and treatment. It is a very challenging condition to diagnose. Patients may collapse and die while undergoing investigation. Aims To assess surgical treatment given to patients presenting at Mpilo Central Hospital, the challenges that are faced and the outcomes; and also to document how women survive this dangerous condition in a setting challenged by low resources...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28333552/treatment-of-multiple-sclerosis-during-pregnancy-safety-considerations
#20
Jan Thone, Sandra Thiel, Ralf Gold, Kerstin Hellwig
Women with multiple sclerosis (MS) are treated early in the disease course with disease modifying therapies (DMT). Updated information is needed on pregnancy outcomes of DMT-exposed pregnancies and the effect of the drug withdrawal on MS disease activity. Areas covered: In this review, we will cover the most important updated management strategies in planning a pregnancy when having MS. Expert opinion: MS itself does not increase the risk of adverse pregnancy outcomes and does not negatively influence the long-term course of the disease...
March 23, 2017: Expert Opinion on Drug Safety
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