Yang Lin, Kimihiko Banno, Chang-Hyun Gil, Jered Myslinski, Takashi Hato, W Christopher Shelley, Hongyu Gao, Xiaoling Xuei, Yunlong Liu, David Basile, Momoko Yoshimoto, Nutan Prasain, Stefan P Tarnawsky, Ralf H Adams, Katsuhiko Naruse, Junko Yoshida, Michael P Murphy, Kyoji Horie, Mervin C Yoder
Most circulating endothelial cells are apoptotic, but rare circulating endothelial colony forming cells (C-ECFCs, also known as blood outgrowth endothelial cells (BOECs)) with proliferative and vasculogenic activity can be cultured; the origin and naïve function of these C-ECFCs remains obscure. Herein, detailed lineage tracing reveals murine C-ECFCs emerge in the early postnatal period, display high vasculogenic potential, with enriched frequency of clonal proliferative cells compared to tissue-resident ECFCs, and are not committed to or derived from the bone marrow hematopoietic system but from tissue-resident ECFCs...
January 24, 2023: JCI Insight